119 results about "Dexamethasone acetate" patented technology

The invention provides a completely new process route for synthesizing dexamethasone and series products thereof. The invention adopts 1, 4, 9, 16-tetraene-pregna-3, 20-diketone as the original material which is modified by 9, 11bits, 16, 17 bits and 21 bits so as to obtain the dexamethasone and the series products thereof such as dexamethasone acetate and dexamethasone sodium phosphate and the like. The process has the advantage that the invention adopts the existing intermediates of manufacturers as the original material; the route is simple; the materials are available; the use of expensive accessories is avoided; the yield and the cost are dramatically better than that of the prior methods used for synthesizing the dexamethasone and derivatives thereof; moreover, the adoption of the existing intermediates realizes the combined-line prodction of the betamethasone series products and the dexamethasone series products, thus greatly reducing the manufacturing cost and the industrial manufacturing condition.

The invention relates to a medicament for nerve regeneration promotion, and particularly to a nerve regeneration promotion injection and a preparation method thereof. The nerve regeneration promotion injection is composed of the following ingredients in proportion: 280-320 micrograms of mouse nerve growth factor for injection, 19-21ml of single sialic acid four hexose ganglioside sodium injecta, 18-22ml of cerebroside-kinin injecta, 9-11ml of mecobalamine injecta and 9-11ml of dexamethasone acetate injecta. The five effective ingredients of the medicament provided by the invention are combined together and cooperative actions of multiple nutritive factors are utilized, so that the medicament has a significant curative effect on repairing of injured nerve, especially the repairing of spinal nerve injury. The medicament provided by the invention also has a protection effect on spinal cord transected injury at the early stage.

A medicine for treating the intractable tinea, including psoriasis and syphilis, is prepared from 17 raw materials including VB1, VB2, VB6, chlorpheniramine, furazolidone, dexamethasone acetate, etc.

The invention discloses compound dexamethasone acetate nano-cream and a preparation method therefor. The cream comprises the following raw materials: dexamethasone acetate, camphor, menthol, a surfactant, a cosurfactant, an oil phase, a cream base material and water. The preparation method for the compound dexamethasone acetate nano-cream comprises the following steps: dissolving dexamethasone acetate in the oil phase, the surfactant and the cosurfactant, and uniformly mixing with the water to obtain nano (micro) emulsion; dispersing camphor, menthol and the nano-emulsion in the cream base and mixing uniformly to obtain the compound dexamethasone acetate nano-cream. The compound dexamethasone acetate nano-cream has the advantages of good smearing property and good transdermal effect.

The invention relates to a preparation method for dexamethasone sodium phosphate. The preparation method comprises the following steps: a ring-opening reaction is carried out, namely, dexamethasone acetate epoxide is employed as an initial raw material, HF and DMF are added, a reaction is performed for 3h, a ring-opening reaction is carried out and a dexamethasone acetate solution is prepared; recrystallization is carried out, namely, methanol is added in the dexamethasone acetate solution, recrystallization is carried out, and dexamethasone acetate is prepared; base catalysis hydrolysis is carried out, namely, dexamethasone acetate is added in Na2CO3 and methanol, a reaction is carried out for 10min, dexamethasone is prepared; pyrophosphoryl chlorine esterification is carried out, namely, dexamethasone prepared in the third step is reacted with pyrophosphoryl chlorine and THF, and dexamethasone phosphate ester is prepared; a neutralization salt forming reaction is carried out, namely, the dexamethasone phosphate ester obtainedin the fourth step is reacted with NaOH and methanol at a reaction temperature of 20 DEG C-30 DEG C for 1h, and dexamethasone sodium phosphate is prepared. The steps are simple, raw materials are easily available, the reaction conditions are mild, the method is suitable for industrial production, and the cost is low.

The invention discloses a compound dexamethasone acetate gel preparation, a preparation method thereof, a pH value check method and a relevant substance check method. The gel is prepared from the raw materials of dexamethasone acetate, camphor, menthol, propylene glycol, absolute ethyl alcohol, polysorbate 80, hydroxypropyl methylcellulose, Carbomer, triethanolamine and optionally ethyl hydroxy benzoate and/or brilliant blue. The compound dexamethasone acetate gel belongs to a replacement product of compound dexamethasone acetate cream, and has therapeutical effects on regional pruritus, neurodermatitis, contact dermatitis, seborrhoeic dermatitis and chronic eczema. Compared with the compound dexamethasone acetate cream, the gel has the advantages of better dispersibility, strong adhesion, high stability, long-lasting drug action, convenient operation, easy cleaning and the like.

The invention relates to a cosmetic, and especially relates to a skin care cream containing a vetiver essential oil. The skin care cream is mainly composed of vaseline, olive oil, octadecanol, glycerin, dexamethasone acetate, a pearl powder, propylene glycol, allantoin, the vetiver essential oil, disodium ethylene diamine tetraacetate, a tarragon essential oil, an amyris essential oil, silk fibroin peptide, an essential amino acid, hyaluronic acid and deionized water. The skin care cream is capable of purifying and astringing skin and resisting infection, contains dexamethasone acetate, can greatly relieve an allergic reaction of people with allergic physique to the skin care cream and an external environment, can adjust oil secretion of the skin, repairs skin cell tissues, relieves inflammation symptoms, and improves oil secretion, comedo, acne and other skin problems.

The invention relates to a composition for treating pruritus and acne and a preparation method thereof. The composition mainly comprises, by mass, 0.01-0.1% of dexamethasone acetate, 0.1-0.5% of chlorphenamine maleate, 2.5-10% of chloramphenicol, 12-25% of compound sulfamethoxazole and 64.4-85% of compound ketoconazole ointment.

The invention discloses a pharmaceutical composition for treating bronchial asthma and application thereof. The pharmaceutical composition contains morroniside and dexamethasone acetate in a weight ratio of 60-360 to 1. The pharmaceutical composition has the important advantages that morroniside and dexamethasone acetate are coordinated to relieve asthma, improve the lung function of a rat with bronchial asthma, as well as reduce airway responsiveness, so as to reach the purpose of treating bronchial asthma.

The invention provides a traditional Chinese medicine and western medicine composition for treating kinds of pruritus cutanea. The traditional Chinese medicine and western medicine composition is prepared from the following raw materials in parts by weight: 10-30 parts of selenium hydrochloride cyproheptdine, 1-50 parts of dexamethasone acetate, 10-30 parts of chlortrimeton, 1-50 parts of vitamin B1, 10-50 parts of vitamin B2, 1-15 parts of vitamin C, 10-30 parts of coptis chinensis, 1-50 parts of tuber fleeceflower stem, 1-15 parts of golden larch bark, 10-50 parts ofhibiscus syriacus, 1-19 parts of kadsura root-bark and 5-50 parts of pomegranate bark. The traditional Chinese medicine and western medicine composition provided by the invention is used for treating kinds of pruritus cutanea, and has the characteristics of good curative effect, fast acting and low recurrence rate.

The invention discloses a Chinese and western medicine preparation used for treating allergic rhinitis and a preparation method thereof. The Chinese and western medicine preparation used for treating allergic rhinitis comprises traditional Chinese medicine raw materials including periostracum cicada, flos magnolia, as arum, radix angelicae dahuricae, ligusticum, xanthium strumarium, endothelium corneum gigeriae galli, bighead atractylodes rhizome, limacia sagittata, pericarpium citri reticulatae, polygala tenuifolia, dried hawthorn, clove, alpinia katsumadai, giner processed pinellia, herba houttuyniae and gentian, and western medicine components including vitamin B1, vitamin B2, vitamin B6, vitamin C, oryzanol, metronidazole, cyproheptadine hydrochloride, cinnarizine and dexamethasone acetate. The new simple and reasonable formula is provided, and the Chinese and western medicine preparation not only has the effect of eradicating allergic rhinitis, but also can effectively avoid stimulation to the alimentary canal and side effects to the nervous system from the metronidazole and the cyproheptadine hydrochloride in the western medicine components.

The invention relates to the technical field of medicine, provides an application of LMWH (low-molecular weight heparin) in preparation of medicine for treating itch, and further provides an LMWH gel preparation. An animal itch model proves that the gel preparation has an anti-itching function superior to compound dexamethasone acetate cream. The novel medical application of LMWH is developed, and a novel treatment means is provided for clinical anti-itching treatment.

The invention relates to a preparation technology for dexamethasone sodium phosphate. The preparation technology comprises the following steps: a ring-opening reaction is carried out, namely, dexamethasone acetate epoxide is employed as an initial raw material, HF and DMF are added, a reaction is performed for 3h, a ring-opening reaction is carried out and a dexamethasone acetate solution is prepared; recrystallization is carried out, namely, acetone or ether is added in the dexamethasone acetate solution, recrystallization is carried out, dexamethasone acetate is prepared, and rotary distillation is employed to remove the solvent after recrystallization; base catalysis hydrolysis is carried out, namely, dexamethasone acetate is added in Na2CO3 and methanol, a reaction is carried out for 10min, dexamethasone is prepared; pyrophosphoryl chlorine esterification is carried out, namely, dexamethasone is reacted with pyrophosphoryl chlorine and THF, and dexamethasone phosphate ester is prepared; a neutralization salt forming reaction is carried out, namely, the dexamethasone phosphate ester obtained from the fourth step is reacted with NaOH and methanol, and dexamethasone sodium phosphate is prepared. The steps are simple, raw materials are easily available, the reaction conditions are mild, the preparation technology is suitable for industrial production, and the cost is low.

The invention discloses cyclosporine cream for treating lupus erythematosus or psoriasis, a method for manufacturing the cyclosporine cream and application thereof. The cyclosporine cream, the method and the application have the advantages that scientific compatibility of emulsifiers and oil phases is determined, accordingly, high skin transmission of cyclosporine can be guaranteed, the cyclosporine and dexamethasone acetate are jointly applied to manufacture the cream, the cream can directly act at affected parts, synergistic effects of immune inhibition and anti-inflammation pharmacological mechanisms of the cyclosporine and the dexamethasone acetate can be realized, excellent effects for treating skin symptoms of the lupus erythematosus and the psoriasis can be realized, and the cyclosporine cream is safe and effective when locally applied; the method for manufacturing the cream is simple and feasible and is easy to popularize, and the cream can be manufactured under mild conditions.

The invention discloses a drug composition for sterilization and itching-relieving. The drug composition comprises, by weight, 2300 to 2500 parts of Vaseline, 370 to 380 parts of dexamethasone acetate, 0.8 to 1.2 parts of cyproheptadine hydrochloride, 4 to 6 parts of vitamin B, 110 to 120 parts of menthol, 110 to 120 parts of salicylic acid, 110 to 120 parts of carbolic acid and 110 to 120 parts of boracic acid. An effective dose of dexamethasone acetate has effects of diminishing inflammation and resisting allergy. An effective dose of cyproheptadine hydrochloride has the effect of resisting allergy. An effective dose of vitamin B has the effect of adjusting human acidity. Effective doses of weak acids such as salicylic acid, carbolic acid and boracic acid have drug effects of sterilization and disinfection. An effective dose of menthol has effects of relieving itching, diminishing inflammation and relieving pain, can produce local cool sense and has the obvious effect of relieving pain. Vaseline has a good lubrication effect, can be used as a solvent, has strong adhesion to effective drugs, and has the obvious effects of lubrication and maintenance.

The invention discloses medical facial cold compress gel for improving sensitive skin problems. The medical facial cold compress gel comprises an active extract, sodium hyaluronate, carbomer and hydrogel, wherein the active extract is an extract of salvia miltiorrhiza, caulis spatholobi, corydalis tuber, ligusticum chuanxiong hort, rhizome of rehmannia, cynomorium songaricum, bitter gourd, tonguesole, aloe, semen cassia, rosin, cicada slough, golden larch bark and folium eucalypti; the weight ratio of the active extract to the sodium hyaluronate to the carbomer to the hydrogel is 10 to 1-10 to 1-10 to 10-50. The invention further discloses a preparation method of the medical facial cold compress gel for improving sensitive skin problems. The medical facial cold compress gel for improvingsensitive skin problems disclosed by the invention is capable of effectively treating symptoms occurring in sensitive skin, such as itching, stabbing pain, scorching hot, tight skin, red and swollen and the like, has a high effective treatment ratio, and achieves the level of a conventional common medicine compound dexamethasone acetate.

The invention discloses a Chinese and western medicine composition for treating anaphylactic rhinitis. The composition is prepared from periostracum cicada, biond magnolia flower, asarum sieboldii, ligusticum wallichii, radix angelicae, chinese ligusticum rhizome, xanthium strumarium, vitamin B1, vitamin B2, vitamin B6, vitamin C, oryzanol, metronidazole, cyproheptadine hydrochloride, cinnarizine and dexamethasone acetate, and comprises seven traditional Chinese medicines and nine western medicines. The composition has effects of expelling wind and removing cold, cooling in two-directional regulation, and dehumidifying and detoxifying, and fast in effect of dredging the bores, dispelling dampness and removing pus for cold, winde syndrome of head, headache, rhinobyon, nasosinusitis, burbid nasal discharge, and in particular anaphylactic rhinitis, and has effect of radical treatment.

The invention discloses an external medicine for treating beriberi. The external medicine is characterized by be prepared from the following raw materials by weight: 3-7 g alumen, 3-7 g mothball, 3-7 g sulfur, 3-7 g borneol, 1-6 g boric acid powder, 1-6 g realgar, 1-6 g calcined plaster, 0.5-3 g metronidazole, 0.5-3 g compound dexamethasone acetate and 0.5-3 g clotrimazole. All the medicines perform functions together to realize combined internal and external therapy, avoid allergy symptoms, effectively treat beriberi, and achieve the effects of clearing heat, drying dampness, detoxifying, relieving itching, activating blood circulation and promoting granulation.

The present invention relates to a preparation method, uses and a use method of a dexamethasone implant for kidney, wherein the dexamethasone implant comprises dexamethasone or dexamethasone acetate, a degradable polymer material, and a water soluble auxiliary material. The preparation method comprises: crushing various materials, mixing, carrying out micro-spheroidization, carrying out mold pressing molding, and heating for a certain time at a proper temperature to prepare the cylindrical implant with a diameter of 0.2-0.9 mm and a length of 0.8-4 mm. According to the present invention, the implant has characteristics of smooth surface and uniform drug release in vivo, wherein the time for releasing 90% of the drug is 1 month to 1 year; and the implant can be implanted into the renal sac through a drug implanting needle so as to treat nephrotic syndrome, nephritis and other chronic kidney diseases.

The invention relates to a method for detecting effective components in a compound dexamethasone acetate emulsifiable paste online by virtue of near infrared spectroscopy, belonging to the technical field of medicine detection. The method for detecting compound dexamethasone acetate emulsifiable paste online by virtue of near infrared spectroscopy provided by the invention comprises the following steps: collecting a near infrared spectrum chart of a compound dexamethasone acetate emulsifiable paste standard substance online; carrying out data treatment on a characteristic spectrum by adopting a partial least square method; and then obtaining a predicted value of effective component content in the standard substance according to an established mathematical model so as to evaluate the quality of compound dexamethasone acetate. The method provided by the invention can be used for simultaneously determining multiple components and various indexes of a sample and is simple to operate without damaging the sample; the method can be used for achieving online real-time test and meanwhile the method is good in reproducibility and stability and less in personal error.

The invention provides a dexamethasone acetate oral tablet, which comprises a drug-containing adhesive layer and a water-insoluble protective layer; wherein a plasticizer in the water-insoluble protective layer adopts triethyl citrate. The invention also provides the preparation method of the dexamethasone acetate oral tablet, which comprises the following steps: 1) dexamethasone acetate is dissolved after added with absolute ethyl alcohol and then added and mixed with dextrin and part of carbomer for granulation, and drug-loading particles are obtained after drying and rounding; 2) the rest of carbomer is drily pressed for granulation, so as to obtain carbomer particles; 3) the drug-loading particles obtained from the step (1) and the carbomer particles obtained in the step (2) are mixedwith magnesium stearate for being pressed into tablets; and 4) spray coating liquid containing polyacrylic resin II, the triethyl citrate, titanium dioxide and a coloring matter is sprayed on the surfaces of the tablets. The dexamethasone acetate oral tablet prepared by the invention is good in uniformity among different batches and low in fragility, thereby improving the stability of the tablet quality.

The invention relates to a dexamethasone acetate injection and a preparation method. specifically, the dexamethasone acetate injection contains an active ingredient, namely, dexamethasone acetate, sodium chloride, water for injection and the like. The dexamethasone acetate injection is prepared with a conventional method. the dexamethasone acetate injection has good technical effects in the specification.