New type medicinal film for treating oral cavity and brotic wound surface and its preparation method

A technology for oral ulcers and drug film, applied in the field of new drug film, can solve the problems of unbearable numbness, patient discomfort, poor local adhesion, etc., and achieve the effect of obvious curative effect, convenient use and long acting time.

Inactive Publication Date: 2005-10-26
FUZHOU JINXIANG CHINESE MEDICINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional method of topical administration is to directly spray or distribute the drug powder or liquid on the affected part of the oral cavity. The disadvantage is that the drug diffuses in the oral cavity, which not only tastes bitter but also numbs unbearably, which makes the patient feel extremely uncomfortable. Disadvantages such as being washed away by saliva and poor local adhesion will affect the therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A new type of medical film for treating oral ulcer wounds, which includes a plastic-coated paper layer, a composite film layer and a medical film layer. The medical film layer is located between the plastic-coated paper layer and the composite film layer. Mycin is 30 units, containing 0.1 mg of tetracaine hydrochloride, and 0.003 mg of dexamethasone acetate.

[0022] The making method of making 10,000 new-style medicated membranes for the treatment of oral ulcer wounds is:

[0023] (1) Preparation of film-forming material slurry: put 600g of polyvinyl alcohol weighed in a beaker, add 1 / 2 of the prepared purified water, heat it in a water bath to dissolve it into a slurry, and heat it at 60-100°C to dissolve After filtering.

[0024] (2) Preparation of drug-containing slurry: a. Dissolve gentamicin sulfate containing 3 million units, 10 g of tetracaine hydrochloride, 2.5 g of stevioside, and 15 g of anhydrous sodium bisulfite in purified water with 1 / 4 of the prepared t...

Embodiment 2

[0028] A new type of medical film for treating oral ulcer wounds, which includes a plastic-coated paper layer, a composite film layer and a medical film layer. The medical film layer is located between the plastic-coated paper layer and the composite film layer. Mycin is 130 units, containing 0.6 mg of tetracaine hydrochloride, and 0.018 mg of dexamethasone acetate.

[0029] The making method of making 10,000 new-style medicated membranes for the treatment of oral ulcer wounds is:

[0030] (1) Preparation of film-forming material slurry: put 1200g of polyvinyl alcohol weighed in a beaker, add 1 / 2 of the prepared purified water, and heat it in a water bath to dissolve it into a slurry. The heating temperature is 60-100 degrees Celsius, and dissolve After filtering.

[0031] (2) Preparation of drug-containing slurry: a. Dissolve 13 million units of gentamicin sulfate, 60 g of tetracaine hydrochloride, 7.5 g of stevia, and 40 g of anhydrous sodium bisulfite in purified water Th...

Embodiment 3

[0035] A new type of medical film for treating oral ulcer wounds, which includes a plastic-coated paper layer, a composite film layer and a medical film layer. The medical film layer is located between the plastic-coated paper layer and the composite film layer. Mycin is 100 units, each square centimeter contains 0.4 mg of tetracaine hydrochloride, and each square centimeter contains 0.012 mg of dexamethasone acetate.

[0036] The making method of making 10,000 new-style medicated membranes for the treatment of oral ulcer wounds is:

[0037] (1) Make a membrane material slurry: put 925g of polyvinyl alcohol weighed in a beaker, add 1 / 2 of the prepared purified water, heat it in a water bath to dissolve it into a slurry, the heating temperature is 60-100 degrees Celsius, dissolve After filtering.

[0038] (2) Preparation of drug-containing slurry: a. Dissolve gentamicin sulfate containing 10 million units, 40 g of tetracaine hydrochloride, 5 g of stevia, and 27.5 g of anhydrou...

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PUM

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Abstract

A medicinal film for treating oral ulcer is composed of a plastics coated paper layer, a composite film layer, and a medicine layer as sandwich which is proportionally prepared from gentamycin sulfate, menonasal and dexamethasone acetate. Its preparing process includes preparing film slurry, preparing medicine slurry defoaming and preparing film.

Description

technical field [0001] The invention relates to a novel medicinal film mainly used for treating oral ulcer wounds, and a preparation method thereof. Background technique [0002] Oral ulcers are a common disease in oral mucosal diseases, and the incidence rate is second only to odontosis. Its pathogenesis is often related to viral infectious diseases or immune dysfunction. The pain caused to the patient is very obvious: periodic attacks, persistent painful erosions. In severe cases, the erosion surface still hurts when the oral cavity is in a static state. For most patients, it takes about 7-12 days for the oral erosions to heal naturally. [0003] In addition to systemic medication for the treatment of oral erosions, topical medication is the preferred treatment option. Most of the topical drugs currently used clinically are hormones or traditional Chinese medicine preparations, such as corticosteroids prednisone, dexamethasone, antibiotics and circulation-promoting dru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036
Inventor 徐燕和
Owner FUZHOU JINXIANG CHINESE MEDICINE PHARMA
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