13 results about "Topical medication" patented technology

The application provides a drying method of Chuanxiong medicinal material and application of Chuanxiong or its extract in preparation of an external medicine for treating atopic dermatitis. The drying method of Chuanxiong medicinal material improves Chuanxiong processing efficiency, shortens processing period, obtains by-product Chuanxiong extract in addition to preparation of decoction pieces, reduces energy consumption and lowers production cost. The Chuanxiong essential oil and Chuanxiong extract are both composed of small molecule components, have good affinity to skin, are absorbed through skin quickly, can quickly relieve symptoms such as itching and skin damage caused by atopic dermatitis, and are natural, safe and free of side effects. Meanwhile, the small molecule components contained in the Chuanxiong essential oil and Chuanxiong extract have good lipophilicity, have softening effect on the thickened stratum corneum caused by atopic dermatitis, and are more conducive to drug absorption. In addition, the Chuanxiong essential oil and Chuanxiong extract are simple to prepare and low in price.

This invention discloses a nasal topical medication application system, relating to the technical field of nasal topical medication application devices. To improve the medication application effect, the device includes a receiving bottle with a dispensing section at its top. Delivery pipes are fixed to the inner walls of both sides of the top of the receiving bottle via fixed supports. The delivery pipes are located at the center of the inner side of the dispensing section, and an airflow channel is provided between the delivery pipes and the dispensing section. The system includes the aforementioned medication application device, as well as a nasal topical medication formula and a preparation method for the formula. The formula includes the following components: seawater and purified water. This invention features a stirring mechanism. The user can press the connecting rod to apply an axial force to the rotating column. The sliding ball and the spiral groove form a sliding engagement, causing the rotating column to rotate, which in turn drives the stirring part to rotate, achieving stirring and avoiding uneven mixing of the drug components, thus improving the medication application effect.

The invention relates to a process for obtaining an amphotericin B (AmB) formulation in liposomes containing dicetyl phosphate (DCP), based on incorporation of the drug into the membrane of preformed liposomes, combining the effects of pH on the solubility of amphotericin B and of temperature on the insertion of the drug into the liposome membrane. The technology also relates to use of the process and of the formulation for the manufacture of medicaments for the treatment of leishmaniasis and sporotrichosis, for oral or topical administration.

This invention provides a hydrogel for treating atopic dermatitis and its applications, relating to the field of biomedical technology. The hydrogel comprises SA, plasma water, L-G2, and / or FLA. Preliminary evaluation of the hydrogel was conducted through in vitro cytotoxicity and antibacterial performance tests, confirming its ability to inhibit Staphylococcus aureus and Escherichia coli. Simultaneously, the hydrogel exhibits low cytotoxicity, meeting the basic requirements for biomedical dressings. In animal experiments, by comparing skin lesions before and after treatment in AD mice, the hydrogel was observed to significantly improve skin lesions on the back of mice, demonstrating good anti-inflammatory effects. Pathological histological analysis showed that the hydrogel can reduce epidermal thickness, inhibit the increase in TNF-α levels induced by DNCB, and promote inflammation relief. Simultaneously, SA can provide a moist healing environment for skin wounds, helping to promote wound repair. Therefore, this hydrogel provides a new strategy for the treatment and management of AD and is expected to become a novel topical drug for AD treatment.

This invention belongs to the field of traditional Chinese medicine technology, and relates to a topical Chinese medicine composition, topical drug, topical patch, acupoint patch, and preparation method and application for treating nausea and vomiting caused by chemotherapy for intracranial tumors. The Chinese medicine composition consists of the following raw materials in parts by weight: 1-2 parts of Ligusticum chuanxiong, 1-2 parts of Gastrodia elata, 2-4 parts of Uncaria rhynchophylla, 1-2 parts of Citrus aurantium, 1-2 parts of Sinapis alba, 1-2 parts of Clematis chinensis, 0.5-1 part of Melia toosendan, 0.5-1 part of Panax ginseng, 1-2 parts of Pinellia ternata, 1-2 parts of Albizia julibrissin bark, 0.5-1 part of Lentinus edodes, and 1-2 parts of Astragalus membranaceus. This Chinese medicine composition has the effects of relieving nausea and vomiting, soothing the liver and strengthening the spleen, detoxifying and eliminating turbidity, calming the liver and extinguishing wind, and calming the mind and soothing the nerves. It not only effectively controls the nausea and vomiting symptoms caused by chemotherapy for intracranial tumors, but also harmonizes the body's Qi and organ functions. The Chinese medicine composition has a simple formula, widely available ingredients, and a simple preparation method; it is for topical application, convenient for clinical use, and has low adverse reactions.

This invention provides the application of exercise-induced sweat extract from healthy individuals in the preparation of a topical medication for diabetic foot ulcers, belonging to the field of biomedicine. Addressing the problems of high cost and limited efficacy of existing treatments, this invention creatively proposes to collect, wash, centrifuge, and filter sweat from healthy individuals induced by specific moderate-intensity aerobic exercise to prepare a sterile extract, which can be used as an active ingredient for topical treatment of diabetic foot ulcers. This sweat extract is rich in various bioactive components. In vitro transcriptomic analysis shows that it can reverse the abnormal gene expression profile associated with diabetic foot ulcers. In vivo animal experiments have confirmed that its topical application can significantly accelerate the healing of diabetic wounds through multi-target synergistic effects of anti-inflammation, angiogenesis, epithelialization, and collagen deposition, with effects comparable to recombinant growth factors. This invention provides a novel treatment strategy that is natural, safe, low-cost, and highly effective, with broad clinical application prospects.

The present application relates to the technical field of medical devices, in particular to a continuous skin external medicine coating device, comprising a medicine storage box for loading medicine liquid, the bottom of the medicine storage box is fixedly connected with a driving box; the bottom of the driving box is provided with a medicine coating assembly; the medicine coating assembly comprises a bottom plate fixedly connected to the bottom of the driving box, a medicine coating roller shaft is arranged on the bottom plate, and a driving assembly for driving the medicine coating roller shaft to oscillate and coat medicine is arranged in the driving box; an expansion piece is arranged on the side wall of the bottom plate, a massage roller shaft is arranged at one end of the expansion piece, and a massage assembly for driving the massage roller shaft to massage the skin is arranged on the bottom plate. The present application is used for continuous and uniform coating of skin external medicine, and integrates massage for absorption promotion, medicine liquid quantitative delivery and self-disinfection function, so as to improve medicine coating standardization, medicine efficacy utilization rate and use safety.

This invention provides a pharmaceutical composition for promoting fracture healing, its preparation method, and its application. The composition, by weight, comprises 25-50 parts of an active core component, 8-25 parts of an osteogenic synergistic bioactive component, 3-15 parts of a bone-targeting transdermal penetration enhancer, and 5-15 parts of a moisturizing dispersant. The active core component is based on bone-healing traditional Chinese medicines such as calcined natural copper nanoparticles and Eupolyphaga sinensis polypeptides. The osteogenic synergistic component is based on collagen peptides of specific molecular weights and graded sodium hyaluronate. The bone-targeting transdermal penetration enhancer is a compound of eugenol and limonene. This invention utilizes a three-dimensional synergistic formulation structure and a phase-separated low-temperature preparation process, overcoming the shortcomings of traditional topical medications, such as poor transdermal targeting, weak efficacy, easy inactivation, and low safety. It can achieve targeted enrichment at fracture ends, synergistically promoting fracture healing throughout its entire life cycle, and simultaneously repairing bone and soft tissue. It is suitable for promoting the repair of various fractures and possesses extremely high clinical value and promising prospects for widespread application.

This invention relates to the field of intelligent medical information technology, providing an information-based planning system for acne patients based on the IMB model. The system collects facial acne characteristics, medication adherence, and facial oil characteristics data from acne patients. It constructs a gridded oil-matching medication adherence index and a gridded acne condition index. Through oil secretion gradient weighted fusion and dynamic condition calibration, it outputs the facial gridded drug utilization rate results. Furthermore, it identifies the influencing factors of each facial grid and performs spatial aggregation to generate medication adherence planning instructions that match the individual's facial region characteristics. This invention forms a closed-loop process from condition gridded perception, multi-dimensional behavior quantification, drug utilization rate attribution assessment to regional targeted intervention. It achieves refined and intelligent acne medication management based on differences in facial oil secretion and lesion aggregation characteristics, significantly improving the accuracy of individualized intervention for acne patients' topical medication behavior.

This invention relates to topical pharmaceutical preparations containing nanosystems based on Lippia sidoides Cham. (rosemary-pepper) essential oil or thymol, indicated for the treatment of inflammatory diseases. The present invention relates to topical pharmaceutical preparations containing nanosystems such as polymeric nanoparticles or nanoemulsions, based on Lippia sidoides Cham. essential oil, or the isolated compound thymol, carried in pharmaceutical preparations in liquid or semi-solid forms, indicated for the treatment of inflammatory diseases. This invention also contemplates the standardization of the essential oil used as an active ingredient in these preparations, as well as the method of preparing the nanosystems consisting of polymeric nanoparticles or nanoemulsions, as well as their compositions and their potential in the treatment of inflammatory diseases.

To provide a topical pharmaceutical composition containing diclofenac in which crystal precipitation is suppressed. [Solution] A topical pharmaceutical composition comprising (A) one or more selected from the group consisting of loxoprofen, its salts and hydrates thereof, (B) one or more selected from the group consisting of diclofenac, its salts and hydrates thereof, and (C) a lower alcohol, wherein the content of the lower alcohol of (C) is 35% by mass or more and 60% by mass or less based on the total mass of the topical pharmaceutical composition, and the pH of the topical pharmaceutical composition is 5.0 to 7.5.

The utility model relates to medical technology field discloses a kind of plaster components, plaster component includes: plaster paste, including sticking layer, medicine package and heating bag, sticking layer one side is provided with first viscose layer, medicine package is bonded to the side for contacting with skin of first viscose layer, heating bag is fixedly connected with sticking layer, heating bag is filled with spontaneous heating material that contact with air and generate heat;Packaging bag, it is wrapped in the outside of plaster paste, to isolate heating bag and air.The plaster component provided by the utility model is set to heating bag, to facilitate the local temperature of skin to be increased by heat effect, be favorable to make skin pore open, enhance local blood circulation, and then make external medicine better be absorbed by skin and be used, reduce drug resource waste;And by setting packaging bag isolation heating bag and air, to prevent when not using plaster paste, spontaneous heating material in heating bag and air reaction heat generation.

This invention belongs to the field of transdermal drug delivery nanocarrier technology, specifically relating to a nanoliposome using coconut oil as the lipid matrix and a specific Li medicinal herb composition (Alpinia oxyphylla + Artemisia argyi + Patchouli) as a natural penetration enhancer, and its preparation method. This product is a derivative of the core patent "A Natural Transdermal Permeation Enhancer Composition Based on Hainan Li Medicinal Herbs and Its Application" (patent application number: 2026106311990), used to significantly improve the transdermal efficiency and skin retention of the penetration enhancer composition, suitable for topical drugs and functional skin care products, realizing the industrialization extension of the core patent technology.