58 results about "Topical medication" patented technology

The instant invention relates to a semi-solid topical composition containing Pirfenidone and an antimicrobial / antiseptic agent such as Modified Diallyl Disulfide Oxide (M-DDO) and its preparation process, offering advantages compared to other pharmaceutical forms of topical administration known in the state of the art, useful as antifibrotic, anti-inflammatory and antiseptic agent in the prevention, treatment and reversion of acne and post acne lesions. Said compositions is also useful for reducing skin redness, detaining the formation of new acne outbreaks, reversing already existing outbreaks and regenerating skin damage caused by acne.

The application provides a drying method of Chuanxiong medicinal material and application of Chuanxiong or its extract in preparation of an external medicine for treating atopic dermatitis. The drying method of Chuanxiong medicinal material improves Chuanxiong processing efficiency, shortens processing period, obtains by-product Chuanxiong extract in addition to preparation of decoction pieces, reduces energy consumption and lowers production cost. The Chuanxiong essential oil and Chuanxiong extract are both composed of small molecule components, have good affinity to skin, are absorbed through skin quickly, can quickly relieve symptoms such as itching and skin damage caused by atopic dermatitis, and are natural, safe and free of side effects. Meanwhile, the small molecule components contained in the Chuanxiong essential oil and Chuanxiong extract have good lipophilicity, have softening effect on the thickened stratum corneum caused by atopic dermatitis, and are more conducive to drug absorption. In addition, the Chuanxiong essential oil and Chuanxiong extract are simple to prepare and low in price.

The invention belongs to the technical field of skin disease treatment and medicine, and particularly relates to an external pharmaceutical composition for treating atopic dermatitis and a preparation method and application thereof. The medicine composition is liquid medicine composed of blumea balsamifera oil, perfoliote knotweed herb and piper cubeba extract and is specially used for treating the atopic dermatitis (AD). According to the composition, the blumea balsamifera oil is innovatively used as a main component and cooperates with the perfoliote knotweed herb and the piper cubeba extract to form an efficient treatment scheme, and the curative effect of the composition is remarkably superior to that of a traditional method for singly using the blumea balsamifera oil. Experiments prove that the composition can effectively improve the skin barrier function, regulate immune disorder, reduce the levels of serum IgE and TSLP and inflammatory factors IL-4 and IFN-gamma, and reduce inflammatory cell infiltration, so that the AD symptom is relieved, and the recurrence rate is reduced.

This invention discloses a nasal topical medication application system, relating to the technical field of nasal topical medication application devices. To improve the medication application effect, the device includes a receiving bottle with a dispensing section at its top. Delivery pipes are fixed to the inner walls of both sides of the top of the receiving bottle via fixed supports. The delivery pipes are located at the center of the inner side of the dispensing section, and an airflow channel is provided between the delivery pipes and the dispensing section. The system includes the aforementioned medication application device, as well as a nasal topical medication formula and a preparation method for the formula. The formula includes the following components: seawater and purified water. This invention features a stirring mechanism. The user can press the connecting rod to apply an axial force to the rotating column. The sliding ball and the spiral groove form a sliding engagement, causing the rotating column to rotate, which in turn drives the stirring part to rotate, achieving stirring and avoiding uneven mixing of the drug components, thus improving the medication application effect.

The invention belongs to the technical field of medicines. The invention relates to a plaster, in particular to a plaster containing anilinoprofen and a composition. The invention provides an externally applied medicine containing anilinoprofen or a composition containing anilinoprofen and iguratimod. Pharmacodynamic studies show that the aniline-ibuprofen single-prescription plaster can treat osteoarthritis (OA) and rheumatoid arthritis (RA), can effectively inhibit arthrocele and volume increase, remarkably reduces the level of proinflammatory factors, and improves the pathological score of joint tissue. After the anilinoprofen and the iguratimod are combined for use, the curative effect is further enhanced, multiple indexes are obviously superior to those of a single drug group, and an obvious synergistic interaction effect is shown. The iguratimod and anilinoprofen compound preparation disclosed by the invention is developed in an external form such as a gel plaster for the first time, an external compound system of anilinoprofen and iguratimod is innovatively constructed, a safe, effective and convenient novel local treatment choice is provided for OA / RA patients, especially people with oral taboo or needing long-term treatment, and the iguratimod and anilinoprofen compound preparation has good clinical transformation potential and application value.

To search for a new active ingredient that is effective in improvement, treatment, and prevention of periodontal disease, and to provide a periodontal disease preventive or therapeutic agent including the new active ingredient.SOLUTION: A periodontal disease preventive or therapeutic agent containing dextromethorphan and / or a salt thereof, an internal or external periodontal disease preventive or therapeutic medicine, and an oral composition for preventing or treating periodontal disease such as a patch, a liniment, a film, a dentifrice, a mouthwash, or a spray, are provided. As the salt of dextromethorphan, dextromethorphan hydrobromide is preferred.SELECTED DRAWING: Figure 2

The invention discloses an external medicine composition compress bag and a traditional Chinese medicine compound external medicine composition, and relates to the technical field of external medicine compositions and patches, the external medicine composition compress bag is used for manufacturing a traditional Chinese medicine compress bag aiming at breasts and related collateral breasts, axillary lymph nodes, axillary region skin and mammary gland related acupuncture points, the humanization is combined with the human body structure, and the traditional Chinese medicine compress bag is made. And all-directional application is realized. The external medicine composition compress bag comprises a compress bag body, the compress bag body is divided into a lymph node traditional Chinese medicine compress bag, a collateral breast and axilla area skin traditional Chinese medicine compress bag, a breast traditional Chinese medicine compress bag and a breast lower plica area traditional Chinese medicine compress bag through heat bonding partition lines, and each traditional Chinese medicine compress bag sequentially comprises an outer wrapping layer, a heating layer, a traditional Chinese medicine layer and an inner cotton cloth layer from outside to inside. The external use pharmaceutical composition compress bag can be used for household treatment and breast health care.

The invention relates to a process for obtaining an amphotericin B (AmB) formulation in liposomes containing dicetyl phosphate (DCP), based on incorporation of the drug into the membrane of preformed liposomes, combining the effects of pH on the solubility of amphotericin B and of temperature on the insertion of the drug into the liposome membrane. The technology also relates to use of the process and of the formulation for the manufacture of medicaments for the treatment of leishmaniasis and sporotrichosis, for oral or topical administration.

The invention provides a local external medicine composition for treating acne as well as a preparation method and application of the local external medicine composition. The pharmaceutical composition disclosed by the invention is prepared from ozlafloxacin, adapalene, a solubilizer, a surfactant and a solvent, wherein the solubilizer is an alcohol compound and / or an ester compound, the hydrophilic-lipophilic balance value of the surfactant is 20-30, and the pH value of the pharmaceutical composition is 4s < 10 >. According to the pharmaceutical composition disclosed by the invention, the ozlafloxacin and adapalene can be effectively released, and in a stability experiment, the content of the ozlafloxacin and adapalene can be kept stable, obvious degradation does not occur, and the particle size distribution is not obviously changed.

This invention belongs to the technical field of skin disease treatment products, specifically relating to a topical hot compress for treating scleroderma and its preparation method. The topical hot compress for treating scleroderma is made from the following raw materials in parts by weight: 20-40 parts of Artemisia argyi, 20-40 parts of Cinnamomum cassia, 10-20 parts of Sparganium stoloniferum, 10-20 parts of Curcuma zedoaria, 10-20 parts of Loranthus parasiticus, 15-30 parts of Gynostemma pentaphyllum, 10-20 parts of Spirodela polyrhiza, 15-30 parts of Spirodela polyrhiza, 15-30 parts of Ephedra sinica, 20-40 parts of Clematis chinensis, 5-15 parts of Eupolyphaga sinensis, 15-25 parts of Eriocaulon buergerianum, 5-15 parts of Carthamus tinctorius, 3-6 parts of Dracaena cochinchinensis, 3-6 parts of processed Strychnos nux-vomica, 20-40 parts of Vaccaria segetalis, 20-40 parts of Astragalus membranaceus, 10-20 parts of Magnolia officinalis, 10-20 parts of Aconitum carmichaelii, and 22-40 parts of rice wine. This invention is a topical medication that eliminates the need for oral administration, treating the disease externally and guiding the pathogenic factors to a cure. It avoids the inconvenience of bitter medications and effectively relieves symptoms and promotes the cure of localized scleroderma.

The present invention relates to the technical field of polysaccharide material modification, and specifically relates to a high-viscoelastic crosslinked biopolysaccharide gel, a preparation method therefor, and an application thereof. After a carboxyl-group-containing biopolysaccharide and a diaminodiketopiperazine-based crosslinking agent are dissolved and mixed uniformly, a crosslinking reaction is generated under the action of a condensing agent to obtain a high-viscoelastic crosslinked biopolysaccharide gel; following moist heat sterilization, the resulting high-viscoelastic crosslinked biopolysaccharide gel meets conditions for the application thereof, and can be applied to the preparation of injectable formulations, internal filler formulations, or topical pharmaceutical carrier formulations. The crosslinked biopolysaccharide gel prepared according to the present invention exhibits large headroom, in terms of viscoelasticity data, to accommodate moist heat sterilization, which ensures product sterility while guaranteeing the product has good viscoelastic performance, with low cytotoxicity, high product purity, and long service life.

The application discloses a medicine composition for promoting wound healing and a preparation method and application thereof. The medicine composition comprises the following components in parts by weight: 1-10 parts of hemoglobin molecules, 1-5 parts of lipoic acid, 0.1-1 part of acetylcysteine, and 40-80 parts of a solvent; the hemoglobin molecules comprise at least one cysteine part and at least one histidine part, wherein the cysteine part comprises an acetyl group or an ethyl maleoyl group, and the histidine part comprises a benzimidazole derivative group. The application applies lipoic acid and acetylcysteine to the external medicine composition of the hemoglobin molecules modified by acetyl groups or ethyl maleoyl groups in combination, effectively relieves the irritant reaction caused by the hemoglobin modification to the skin through the synergistic antioxidant and tissue protection effects, and thus improves the safety and applicability of the medicine composition in skin wound treatment, and the medicine composition is suitable for treating multiple types of wounds such as external injuries, burns, postoperative wounds and ulcer wounds.

The present invention focuses on the field of mechatronics, and more specifically on orthopedics. It is a body part digitization system designed to generate three-dimensional models for the subsequent manufacture of splints using additive manufacturing techniques. The system consists of a digitizing sensor, which, together with a counterweight, rotates around the body part to be digitized, obtaining a morphology faithful to the scanned body part. The inventive aspect of this system lies in the fact that with only one degree of freedom of the digitizing system, a sufficiently accurate capture of the body part is achieved with the aid of a counterweight. Furthermore, it allows for the creation of a fully customized splint that improves the quality of life of the wearer during immobilization treatment by permitting activities such as washing and / or wetting the affected area, as well as the application of topical products.

The invention provides hydrogel for treating atopic dermatitis and application thereof, and relates to the technical field of biomedicine, and the hydrogel comprises SA, plasma water, L-G2 and / or FLA. Through in-vitro cytotoxicity tests and antibacterial performance tests, preliminary evaluation is carried out on the hydrogel, it is proved that the hydrogel can inhibit staphylococcus aureus and escherichia coli, meanwhile, the hydrogel shows low cytotoxicity, and the basic requirements of biomedical dressing are met. In animal experiments, by comparing skin lesion conditions before and after AD mouse treatment, it is observed that the hydrogel can significantly improve back skin lesion of a mouse and has a good anti-inflammatory effect. Pathohistological analysis shows that the hydrogel can reduce the thickness of epidermis, inhibit the increase of the TNF-alpha level induced by DNCB and promote inflammation relief. Meanwhile, SA can provide a wet healing environment for skin wounds and is beneficial to promoting wound repair. Therefore, the hydrogel provides a new strategy for AD treatment and management, and is expected to become a novel external medicine for AD treatment.

The invention belongs to the technical field of pharmaceutical preparations, particularly discloses a colchicine and lidocaine eutectic mixture as well as a preparation method and application thereof, and aims to solve the problems that colchicine is poor in transdermal effect, large in gastrointestinal tract side effect after oral administration and insufficient to meet the anti-inflammatory and analgesic requirements of acute gout in time. According to the invention, colchicine and lidocaine are mixed according to a molar ratio of 0.1: 0.9-0.9: 0.1 to prepare a eutectic mixture with a melting point of 46.1-64.7 DEG C through a solvent-assisted grinding method, and the eutectic mixture is also prepared into an external pharmaceutical composition. The solubility and transdermal effect of the mixture are remarkably improved, colchicine and lidocaine can be locally and efficiently delivered to lesion joints, the complementary and synergistic effects of the two drugs on anti-inflammatory and analgesic mechanisms are fully played, meanwhile, the gastrointestinal toxic and side effects of oral administration are avoided, the safety is good, the skin tolerance is good, and the application prospect is wide. The medicine is suitable for treating acute gouty arthritis.

This invention provides a hydrogel for treating atopic dermatitis and its applications, relating to the field of biomedical technology. The hydrogel comprises SA, plasma water, L-G2, and / or FLA. Preliminary evaluation of the hydrogel was conducted through in vitro cytotoxicity and antibacterial performance tests, confirming its ability to inhibit Staphylococcus aureus and Escherichia coli. Simultaneously, the hydrogel exhibits low cytotoxicity, meeting the basic requirements for biomedical dressings. In animal experiments, by comparing skin lesions before and after treatment in AD mice, the hydrogel was observed to significantly improve skin lesions on the back of mice, demonstrating good anti-inflammatory effects. Pathological histological analysis showed that the hydrogel can reduce epidermal thickness, inhibit the increase in TNF-α levels induced by DNCB, and promote inflammation relief. Simultaneously, SA can provide a moist healing environment for skin wounds, helping to promote wound repair. Therefore, this hydrogel provides a new strategy for the treatment and management of AD and is expected to become a novel topical drug for AD treatment.

The invention discloses lactobacillus crispatus CCFM1462 and application of a metagen of the lactobacillus crispatus CCFM1462 in promoting skin ceramide synthesis by regulating a sphingomyelinase pathway, and belongs to the technical field of microorganisms and medicines. The lactobacillus crispatus CCFM1462 provided by the invention can effectively improve the content of ceramide in the aspects of external use and oral administration. According to the application disclosed by the invention, it is found that a metagen (fermented supernatant CCFM1462-S) prepared by oral administration of lactobacillus crispatus CCFM1462 can promote expression of sphingomyelinase, so that a sphingomyelinase pathway in a ceramide synthesis process is regulated and controlled, and rapid supplement of ceramide is realized. Therefore, the lactobacillus crispatus plays a crucial role in solving the problem that ceramide needs to be supplemented emergently after skin irritation, has a huge application prospect when being applied to oral or external medicines, and is used for transient stress repair of skin.

The invention discloses a traditional Chinese medicine composition for treating leukoplakia vulvae, the traditional Chinese medicine composition is formed by combining an oral medicine and an external application medicine, the oral medicine is prepared from the following medicinal materials: angelica sinensis, ligusticum wallichii, radix paeoniae rubra, radix rehmanniae preparata, cassia twig, peach kernel, cortex moutan, poria cocos, Chinese yam, dogwood, safflower carthamus, radix bupleuri, herba epimedii, rhizoma curculiginis, morinda officinalis, radix aconiti carmichaeli and cynanchum paniculatum; the external application medicine is prepared from the following medicinal materials: radix angelicae sinensis, rhizoma chuanxiong, radix paeoniae rubra, radix rehmanniae preparata, cassia twig, peach kernel, cortex moutan, poria cocos, rhizoma dioscoreae, fructus corni, flos carthami, radix bupleuri, herba epimedii, rhizoma curculiginis, radix morindae officinalis, radix aconiti carmichaeli, radix cynanchi paniculati, fructus cnidii, cortex phellodendri, radix sophorae flavescentis, fructus kochiae and herba menthae. Clinical symptoms of a patient are effectively relieved, vulva skin lesion is effectively repaired, skin regeneration is promoted, vulva skin is recovered to a normal form, and the life quality of the patient is improved.

This invention belongs to the field of traditional Chinese medicine technology, and relates to a topical Chinese medicine composition, topical drug, topical patch, acupoint patch, and preparation method and application for treating nausea and vomiting caused by chemotherapy for intracranial tumors. The Chinese medicine composition consists of the following raw materials in parts by weight: 1-2 parts of Ligusticum chuanxiong, 1-2 parts of Gastrodia elata, 2-4 parts of Uncaria rhynchophylla, 1-2 parts of Citrus aurantium, 1-2 parts of Sinapis alba, 1-2 parts of Clematis chinensis, 0.5-1 part of Melia toosendan, 0.5-1 part of Panax ginseng, 1-2 parts of Pinellia ternata, 1-2 parts of Albizia julibrissin bark, 0.5-1 part of Lentinus edodes, and 1-2 parts of Astragalus membranaceus. This Chinese medicine composition has the effects of relieving nausea and vomiting, soothing the liver and strengthening the spleen, detoxifying and eliminating turbidity, calming the liver and extinguishing wind, and calming the mind and soothing the nerves. It not only effectively controls the nausea and vomiting symptoms caused by chemotherapy for intracranial tumors, but also harmonizes the body's Qi and organ functions. The Chinese medicine composition has a simple formula, widely available ingredients, and a simple preparation method; it is for topical application, convenient for clinical use, and has low adverse reactions.

This invention provides the application of exercise-induced sweat extract from healthy individuals in the preparation of a topical medication for diabetic foot ulcers, belonging to the field of biomedicine. Addressing the problems of high cost and limited efficacy of existing treatments, this invention creatively proposes to collect, wash, centrifuge, and filter sweat from healthy individuals induced by specific moderate-intensity aerobic exercise to prepare a sterile extract, which can be used as an active ingredient for topical treatment of diabetic foot ulcers. This sweat extract is rich in various bioactive components. In vitro transcriptomic analysis shows that it can reverse the abnormal gene expression profile associated with diabetic foot ulcers. In vivo animal experiments have confirmed that its topical application can significantly accelerate the healing of diabetic wounds through multi-target synergistic effects of anti-inflammation, angiogenesis, epithelialization, and collagen deposition, with effects comparable to recombinant growth factors. This invention provides a novel treatment strategy that is natural, safe, low-cost, and highly effective, with broad clinical application prospects.

1. Name of the product in this design: Dermatological care medicine applicator. 2. Purpose of this design: For applying topical medications to the skin. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a local external cream composition for treating psoriasis. The topical external cream composition for treating psoriasis is prepared from deaminated tyrosine, azone and a matrix, wherein the matrix is prepared from liquid paraffin, sorbitol, an emulsifying agent, tween-80, white vaseline, beewax, glycerin monostearate, solid paraffin and the like according to a specific weight percentage. By optimizing a prescription and a process, the cream composition which is good in stability, high in transdermal absorption efficiency and capable of effectively delivering DAT to a skin focus is prepared, psoriasis-like skin lesion is effectively improved, inflammation and epidermal hyperplasia are relieved, and the cream composition is good in safety. A brand-new, effective and safe external medicine selection and application are provided for the field of psoriasis treatment by taking the deaminated tyrosine as an active component.

The invention provides an essential oil composition. The essential oil composition is prepared from the following raw materials in parts by weight: 0.5-1.5 parts of safflower essential oil, 0.5-1.5 parts of ligusticum wallichii essential oil and 0.5-1.5 parts of angelica sinensis essential oil. The invention also provides application of the essential oil composition in preparation of external medicines for preventing or / treating qi-blood disorder. According to the invention, a synergistic effect mechanism of medicine and massage is adopted, on one hand, pharmacological action is exerted through percutaneous absorption of active substances such as essential oil, and on the other hand, local blood circulation is remarkably promoted, muscle spasm is relieved and medicine permeation efficiency is enhanced by means of a massage technique, so that deep fusion of medicine effect and physical treatment effect is realized, and the traditional Chinese medicine composition takes effect quickly and lasts long; the essential oil raw materials are combined, so that the synergistic interaction effect is achieved; the first-pass effect and gastrointestinal tract adverse reaction can be effectively avoided, and the composition is high in safety and suitable for long-term use.

The invention provides a traditional Chinese medicine composition with anti-inflammatory and bacteriostatic effects and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The pharmaceutical composition is prepared from the following components in parts by weight: 3 to 8 parts of baicalin, 24 to 48 parts of chlorogenic acid, 18 to 45 parts of imperatorin and 36 to 80 parts of ferulic acid. The traditional Chinese medicine composition has good anti-inflammatory and bacteriostatic effects, is clear in active ingredient, small in dosage and high in application value, and is suitable for preparing an external medicine for wound surface infection resistance. The composition can be used for preparing traditional Chinese medicine ointment and gel for efficiently and conveniently treating burns and scalds, and has high practical application value.

The invention provides an external application medicine for thyroid nodules and a preparation method thereof, the medicine is composed of a traditional Chinese medicine compound extract, a targeting active component, a transdermal promotion system and a medicinal matrix, the traditional Chinese medicine compound extract contains multiple medicinal materials such as prunella vulgaris, the targeting component comprises selenium yeast and tetrahydrocurcumin, and the transdermal system is composed of azone and the like. The preparation method comprises the steps of raw material pretreatment, step-by-step extraction, purification and inclusion, and matrix forming. The traditional Chinese medicine composition is scientific in compatibility, high in transdermal absorption efficiency, stable in drug effect, high in safety and convenient to use, can effectively inhibit thyroid nodule hyperplasia and reduce the nodule volume, and is suitable for clinical adjuvant therapy of thyroid nodules.

The potency of a topical corticosteroid in a formulation is maintained even if the concentration of the corticosteroid is substantially reduced by providing the corticosteroid in a formulation containing a liquid oil component comprising a dicarboxylic acid ester and / or a monocarboxylic acid ester.

The invention discloses a traditional Chinese medicine formula for treating diabetic foot and bedsore, and relates to the technical field of traditional Chinese medicine external preparations, the traditional Chinese medicine formula comprises the following medicinal materials in parts by weight: nidus vespae, carbonized hair, coptis chinensis, golden cypress, scutellaria baicalensis, rheum officinale, centipede, scorpion and the like, the components have a synergistic effect under a preferable ratio, and the formula is 80-120-mesh external powder. The traditional Chinese medicine composition is prepared through independent crushing, three-dimensional mixing and other processes, can be used for preparing external medicines for diabetic foot ulcer and bedsore, and can achieve integrated treatment of counteracting toxic substances and removing decay, dispersing blood stasis and promoting tissue regeneration, and astringing sores and closing up.

The present application relates to the technical field of medical devices, in particular to a continuous skin external medicine coating device, comprising a medicine storage box for loading medicine liquid, the bottom of the medicine storage box is fixedly connected with a driving box; the bottom of the driving box is provided with a medicine coating assembly; the medicine coating assembly comprises a bottom plate fixedly connected to the bottom of the driving box, a medicine coating roller shaft is arranged on the bottom plate, and a driving assembly for driving the medicine coating roller shaft to oscillate and coat medicine is arranged in the driving box; an expansion piece is arranged on the side wall of the bottom plate, a massage roller shaft is arranged at one end of the expansion piece, and a massage assembly for driving the massage roller shaft to massage the skin is arranged on the bottom plate. The present application is used for continuous and uniform coating of skin external medicine, and integrates massage for absorption promotion, medicine liquid quantitative delivery and self-disinfection function, so as to improve medicine coating standardization, medicine efficacy utilization rate and use safety.

The present application relates to the technical field of external medicine for treating urticaria, and discloses a composition for treating urticaria, which comprises the following components: Cudrania tricuspidata, Eucalyptus globulus, Cymbopogon citratus, Datura stramonium, Kaempferia rotunda, Sageretia theezans, Gleditsia sinensis, camphor, Gnaphalium affine and Gynura japonica. The composition is externally applied to the skin of the affected part, and has the effects of clearing heat and detoxifying, removing dampness and swelling, dispelling wind and relieving itching.

This invention provides a pharmaceutical composition for promoting fracture healing, its preparation method, and its application. The composition, by weight, comprises 25-50 parts of an active core component, 8-25 parts of an osteogenic synergistic bioactive component, 3-15 parts of a bone-targeting transdermal penetration enhancer, and 5-15 parts of a moisturizing dispersant. The active core component is based on bone-healing traditional Chinese medicines such as calcined natural copper nanoparticles and Eupolyphaga sinensis polypeptides. The osteogenic synergistic component is based on collagen peptides of specific molecular weights and graded sodium hyaluronate. The bone-targeting transdermal penetration enhancer is a compound of eugenol and limonene. This invention utilizes a three-dimensional synergistic formulation structure and a phase-separated low-temperature preparation process, overcoming the shortcomings of traditional topical medications, such as poor transdermal targeting, weak efficacy, easy inactivation, and low safety. It can achieve targeted enrichment at fracture ends, synergistically promoting fracture healing throughout its entire life cycle, and simultaneously repairing bone and soft tissue. It is suitable for promoting the repair of various fractures and possesses extremely high clinical value and promising prospects for widespread application.