152 results about "Topical medication" patented technology

The instant invention relates to a semi-solid topical composition containing Pirfenidone and an antimicrobial / antiseptic agent such as Modified Diallyl Disulfide Oxide (M-DDO) and its preparation process, offering advantages compared to other pharmaceutical forms of topical administration known in the state of the art, useful as antifibrotic, anti-inflammatory and antiseptic agent in the prevention, treatment and reversion of acne and post acne lesions. Said compositions is also useful for reducing skin redness, detaining the formation of new acne outbreaks, reversing already existing outbreaks and regenerating skin damage caused by acne.

The invention belongs to the field of medicine preparations, and particularly relates to a local external medicine composition for treating alopecia, the medicine composition comprises at least one active component, and the medicine composition comprises the following components in percentage by weight: 1-10% w / w of minoxidil or salt thereof, 0-50% w / w of propylene glycol, 1-50% w / w of ethanol and 10-50% w / w of C3-C10 ether solvent, the total dosage of the propylene glycol and the ethanol is less than or equal to 50% w / w, and the total dosage of the propylene glycol and the ethanol is less than or equal to 50% w / w. The pharmaceutical composition at least has the following excellent characteristics: good curative effect, high drug solubility, high patient efficiency, quick response, few adverse reactions, low scalp irritation, good stability, easy use, no greasy feeling after use, good drug permeability, high bioavailability, few use times, good patient compliance and the like.

The invention relates to the technical field of external medicine, and discloses a stable external medicine composition containing fluticasone propionate, which comprises the following components: 0.05% of fluticasone propionate; 10.00% of propylene glycol; 0.05% of triethanolamine; 0.20% of imidazolidinyl urea; 0.8% to 1.2% of carbomer; 5%-20% of paraffin; 0.75% of poly (simtrol); 5.00% of isopropyl myristate; and the balance of purified water. Carbomer is added into the stable external pharmaceutical composition containing fluticasone propionate to replace octadecanol in an original formula, so that the high-temperature stability of fluticasone propionate cream is improved in the preparation and optimization process of the fluticasone propionate cream, and the molecular structure of the Carbomer can be matched with other components in the cream, so that the stability of the fluticasone propionate cream is improved. For example, grease phase molecules and water phase molecules form more stable interaction, at high temperature, grease molecules can be effectively prevented from being excessively gathered due to thermal motion, meanwhile, the stability of the water phase can be enhanced, and water is prevented from being separated out of a cream system.

The invention belongs to the technical field of biological medicines, and particularly relates to a composition for treating atopic dermatitis and application thereof. The composition comprises the following components: pseudo-ginseng extract, artemether, alpine glycoside and oleanolic acid in a mass ratio of (2-4): (2-4): (1-2): (1-2). The composition disclosed by the invention has anti-inflammatory and anti-pruritus effects and can be used for treating atopic dermatitis, eczema and other diseases. The active components of the composition are all from plant sources, the composition has good safety and atopic dermatitis treatment efficacy, the use dosage is low, the components can achieve a synergistic interaction effect, and the composition shows an excellent effect; the composition can be applied to functional skin care products (face cream, emulsion and essence) and external medicines (applying agents and ointments).

The invention belongs to the technical field of external pharmaceutical compositions, and particularly relates to a temperature phase change microsphere antibacterial gel and a preparation method thereof. The gel is composed of three core components: temperature phase change microspheres, a composite antibacterial component and a carbomer matrix solution. The antibacterial component comprises carvacrol, oregano oil, cinnamyl aldehyde, citral, gallic acid and nano-silver, and aims to realize a broad-spectrum and efficient antibacterial effect. Hydrogel is prepared into microspheres (the phase change temperature is 33 DEG C) by utilizing a micro-fluidic chip technology, antibacterial components are wrapped in the microspheres, and then the temperature phase change microsphere antibacterial gel is compounded. When the gel is daily stored, the microspheres can realize long-time activity maintenance of antibacterial components and play a role in protecting the active components. When the gel is smeared on the skin surface, the human body temperature (36-37 DEG C) is higher than the phase change temperature (33 DEG C), the gel microspheres are subjected to phase change, sustained and controlled release of antibacterial components is achieved, and the better antibacterial effect is achieved.

The invention provides an application of protocatechualdehyde in preparation of an external medicine for preventing or / and treating psoriasis. The medicine is used for preventing or / and treating psoriasis, the medicine effect is clear, in-vitro cell experiments prove that the expression level of inflammatory factors such as IL-1alpha and CXCL9 is effectively reduced by inhibiting the phosphorylation of STAT3, the important value of the medicine in scientific research and clinical application is shown, and a new medicine selection is provided for clinic.

Use of cholesterol sulfate or a derivative thereof in the preparation of a composition for treating atopic dermatitis or alleviating symptoms thereof. Cholesterol sulfate or the derivative thereof can inhibit keratinocytes from generating and releasing TSLP, thereby inhibiting the formation of type II inflammation, and can effectively treat or prevent AD and alleviate the symptoms thereof. Provided is a topical medicament or cosmetic comprising cholesterol sulfate or the derivative thereof.

The application provides a drying method of Chuanxiong medicinal material and application of Chuanxiong or its extract in preparation of an external medicine for treating atopic dermatitis. The drying method of Chuanxiong medicinal material improves Chuanxiong processing efficiency, shortens processing period, obtains by-product Chuanxiong extract in addition to preparation of decoction pieces, reduces energy consumption and lowers production cost. The Chuanxiong essential oil and Chuanxiong extract are both composed of small molecule components, have good affinity to skin, are absorbed through skin quickly, can quickly relieve symptoms such as itching and skin damage caused by atopic dermatitis, and are natural, safe and free of side effects. Meanwhile, the small molecule components contained in the Chuanxiong essential oil and Chuanxiong extract have good lipophilicity, have softening effect on the thickened stratum corneum caused by atopic dermatitis, and are more conducive to drug absorption. In addition, the Chuanxiong essential oil and Chuanxiong extract are simple to prepare and low in price.

The invention belongs to the technical field of skin disease treatment and medicine, and particularly relates to an external pharmaceutical composition for treating atopic dermatitis and a preparation method and application thereof. The medicine composition is liquid medicine composed of blumea balsamifera oil, perfoliote knotweed herb and piper cubeba extract and is specially used for treating the atopic dermatitis (AD). According to the composition, the blumea balsamifera oil is innovatively used as a main component and cooperates with the perfoliote knotweed herb and the piper cubeba extract to form an efficient treatment scheme, and the curative effect of the composition is remarkably superior to that of a traditional method for singly using the blumea balsamifera oil. Experiments prove that the composition can effectively improve the skin barrier function, regulate immune disorder, reduce the levels of serum IgE and TSLP and inflammatory factors IL-4 and IFN-gamma, and reduce inflammatory cell infiltration, so that the AD symptom is relieved, and the recurrence rate is reduced.

The invention relates to an external traditional Chinese medicine preparation for preventing and treating HPV (human papillomavirus) infection, which belongs to the technical field of external medicines and comprises the following raw materials: 1-10 parts of gallnut, 1-10 parts of szechwan chinaberry fruit, 1-10 parts of golden cypress, 1-10 parts of fructus cnidii, 1-10 parts of radix sophorae flavescentis, 1-10 parts of cyrtomium rhizome, 1-10 parts of rhizoma atractylodis, 1-10 parts of cortex dictamni, 0-10 parts of calomel, 0-10 parts of cinnabar and 0-10 parts of borneol. The external traditional Chinese medicine preparation disclosed by the invention is locally administrated through the vagina, so that the active ingredients directly reach the focus, and the external traditional Chinese medicine preparation is safe and convenient, and is suitable for resisting HPV infection, cervicitis, cervical erosion, pelvic inflammation, bacterial vaginitis, trichomonas vaginitis, mixed vaginitis, peculiar smell of private parts, pruritus of private parts, dryness of private parts, abnormal leucorrhea and pruritus and causalgia of vulva.

The invention relates to a portable traditional Chinese medicine drenching and soaking rapidly disintegrated and mixed effervescent tablet and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The invention provides an effervescent tablet for treating eczematous dermatitis. The effervescent tablet is prepared from the following components in parts by mass: 10 to 40 parts of extract powder, 20 to 30 parts of citric acid, 15 to 25 parts of sodium bicarbonate, 1 to 3 parts of polyvinylpyrrolidone absolute ethyl alcohol solution, 1 to 9 parts of polyethylene glycol 6000, 15 to 30 parts of lactose and 3 to 7 parts of sodium carboxymethyl cellulose. The effervescent tablet obtained by the preparation method is convenient to use, convenient to carry and store, short in disintegration time, proper in pH value, large in foaming amount, smooth in appearance and clear in solution after disintegration, and the superfine powder for preparing the extract powder can improve the drug wall breaking rate, promote dissolution of effective components, improve the bioavailability and the treatment effect, improve the resource utilization rate and reduce the production cost. The invention provides a brand new dosage form of external medicine for treating eczematous dermatitis.

The invention belongs to the technical field of medicine, and provides an external pharmaceutical composition for waist training injury pain and a patch thereof, the external pharmaceutical composition is prepared from scutellaria baicalensis, angelica sinensis, poria cocos, salvia miltiorrhiza, radix angelicae pubescentis, golden cypress, ligusticum wallichii, frankincense, garden balsam stem, safflower, galangal, liquorice and diclofenac sodium. According to the external medicine composition, the medicines generate a mutual synergistic effect in a manner of combined application of traditional Chinese medicines and western medicines, so that the purpose of enhancing the medicine effect is achieved, and the analgesic effect is remarkable. The combined action of Chinese and western medicines alleviates the side effect of pure western medicines and improves the problem of unstable curative effect of pure traditional Chinese medicines. The external medicine composition is high in safety, free of stimulation, exact in curative effect, free of pain in treatment, high in clinical cure rate and easy to accept by patients after being used for a long time.

The invention discloses application of a CD36 inhibitor in preparation of a medicine for treating psoriasis, and belongs to the technical field of biological medicine. Experiments prove that the ointment containing the CD36 inhibitor can significantly reduce the expression level of psoriasis related inflammatory factors CXCL5 / CXCL8 and CCL20, and reduce the local infiltration of CCR6 + T cells and neutrophils. The CD36 inhibitor ointment can inhibit secretion of inflammatory chemotactic factors related to keratinocyte psoriasis so as to effectively relieve psoriasis-like dermatitis induced by IMQ, and can be used for preparing local external medicines for treating psoriasis.

The present invention belongs to the field of medical technology, and specifically relates to an external-use pharmaceutical composition for treating sore throat, which is mainly composed of the following raw materials by weight: 1-10 parts of cinnamon twig (peeled), 1-15 parts of roasted licorice root, 1-5 parts of raw pinellia, 1-15 parts of kudzu root, 1-10 parts of inula flower, 3-9 parts of chuanxiong and 1-10 parts of magnolia bark. The preparation method thereof is as follows: S1, weighing each raw material by weight; S2, mixing and grinding each raw material weighed in step S1 into powder; S3, sieving, removing the drug residue, and obtaining the drug powder; S4, packaging the drug powder into bags. The pharmaceutical composition of the present invention has the advantages of good therapeutic effect on sore throat and low side effects.

A graduated dose dispenser and applicator for topical medications wherein medications may be dispensed in an accurate and safe manner. The graduated dose dispenser and applicator utilizes a body, plunger, screw rod, pin, knob, channel, plunger lip, detent, alignment ribs, and rounded applicator tip to accurately dispense and apply topical medications.

The invention relates to an amorolfen liniment, and belongs to the field of external pharmaceutical preparations. By adding a specific type of penetration enhancer into the amorolfen liniment, the amorolfen liniment can realize higher retention volume of the medicine in nails and has higher nail penetration capacity, namely, the penetration speed and degree of the medicine on the nails are obviously increased, the defects in the prior art are overcome, and the amorolfen liniment is suitable for clinical application. And a better choice is provided for clinical treatment of nail fungal infection.

This invention discloses a nasal topical medication application system, relating to the technical field of nasal topical medication application devices. To improve the medication application effect, the device includes a receiving bottle with a dispensing section at its top. Delivery pipes are fixed to the inner walls of both sides of the top of the receiving bottle via fixed supports. The delivery pipes are located at the center of the inner side of the dispensing section, and an airflow channel is provided between the delivery pipes and the dispensing section. The system includes the aforementioned medication application device, as well as a nasal topical medication formula and a preparation method for the formula. The formula includes the following components: seawater and purified water. This invention features a stirring mechanism. The user can press the connecting rod to apply an axial force to the rotating column. The sliding ball and the spiral groove form a sliding engagement, causing the rotating column to rotate, which in turn drives the stirring part to rotate, achieving stirring and avoiding uneven mixing of the drug components, thus improving the medication application effect.

The invention belongs to the technical field of medicines. The invention relates to a plaster, in particular to a plaster containing anilinoprofen and a composition. The invention provides an externally applied medicine containing anilinoprofen or a composition containing anilinoprofen and iguratimod. Pharmacodynamic studies show that the aniline-ibuprofen single-prescription plaster can treat osteoarthritis (OA) and rheumatoid arthritis (RA), can effectively inhibit arthrocele and volume increase, remarkably reduces the level of proinflammatory factors, and improves the pathological score of joint tissue. After the anilinoprofen and the iguratimod are combined for use, the curative effect is further enhanced, multiple indexes are obviously superior to those of a single drug group, and an obvious synergistic interaction effect is shown. The iguratimod and anilinoprofen compound preparation disclosed by the invention is developed in an external form such as a gel plaster for the first time, an external compound system of anilinoprofen and iguratimod is innovatively constructed, a safe, effective and convenient novel local treatment choice is provided for OA / RA patients, especially people with oral taboo or needing long-term treatment, and the iguratimod and anilinoprofen compound preparation has good clinical transformation potential and application value.

The present invention discloses a fiber membrane that promotes the healing of infected wounds, a preparation method and an application thereof. The fiber membrane includes a plurality of non-randomly arranged spinning nanofibers, which are prepared by electrostatic spinning from a material including L-polylactic acid. The porous microstructure of the fiber membrane of the present invention provides a suitable microenvironment for cell migration and epithelial regeneration, and can promote the healing of bacterial-infected wounds. It has been verified that the fiber membrane of the present invention can effectively promote wound healing through antibacterial, relieving inflammation, collagen regeneration and angiogenesis. In addition, the present invention can maximize the antibacterial and tissue repair functions without adding external drugs through ultrasound enhanced treatment, and has broad application prospects.

A method for treating squamous cell carcinomas (SCCs), basal cell carcinomas (BCCs), or other cancers of the skin may include administering a plurality of laser pulses to a cancerous lesion using one or more lasers and / or using radio frequency therapy, and, optionally, for a predetermined treatment period, repeatedly applying a topical medication for treating pre- cancerous or cancerous lesions to the cancerous lesion.

The invention provides medical application of copper salt with medical value in preparation of a medicine for relieving photolysis of tigecycline. A minimum inhibitory concentration detection test, a sterilization curve detection, a cell protection test and a mouse staphylococcus aureus skin infection treatment effect experiment prove that the copper salt represented by copper gluconate significantly enhances the treatment effect of tigecycline as an external medicine. The photolysis effect of tigecycline is reduced by adding the copper salt, so that the antibacterial effect of tigecycline under any illumination condition is enhanced. The concentration of the used copper salt is far lower than the antibacterial effect of the copper salt. Therefore, the copper salt represented by the copper gluconate can be used for new drug development. The discovery of the application has very important clinical application value, can greatly promote the medication spectrum and indications of tigecycline as an externally applied drug, can solve the problem that no externally applied antibacterial drug is available for skin or soft tissue infection of various complex drug-resistant bacteria clinically, and can generate great economic benefits at the same time.

To search for a new active ingredient that is effective in improvement, treatment, and prevention of periodontal disease, and to provide a periodontal disease preventive or therapeutic agent including the new active ingredient.SOLUTION: A periodontal disease preventive or therapeutic agent containing dextromethorphan and / or a salt thereof, an internal or external periodontal disease preventive or therapeutic medicine, and an oral composition for preventing or treating periodontal disease such as a patch, a liniment, a film, a dentifrice, a mouthwash, or a spray, are provided. As the salt of dextromethorphan, dextromethorphan hydrobromide is preferred.SELECTED DRAWING: Figure 2

A method for treating squamous cell carcinomas (SCCs), basal cell carcinomas (BCCs), or other cancers of the skin may include administering a plurality of laser pulses to a cancerous lesion using one or more lasers and / or using radio frequency therapy, and, optionally, for a predetermined treatment period, repeatedly applying a topical medication for treating pre- cancerous or cancerous lesions to the cancerous lesion.

The invention discloses an external medicine composition compress bag and a traditional Chinese medicine compound external medicine composition, and relates to the technical field of external medicine compositions and patches, the external medicine composition compress bag is used for manufacturing a traditional Chinese medicine compress bag aiming at breasts and related collateral breasts, axillary lymph nodes, axillary region skin and mammary gland related acupuncture points, the humanization is combined with the human body structure, and the traditional Chinese medicine compress bag is made. And all-directional application is realized. The external medicine composition compress bag comprises a compress bag body, the compress bag body is divided into a lymph node traditional Chinese medicine compress bag, a collateral breast and axilla area skin traditional Chinese medicine compress bag, a breast traditional Chinese medicine compress bag and a breast lower plica area traditional Chinese medicine compress bag through heat bonding partition lines, and each traditional Chinese medicine compress bag sequentially comprises an outer wrapping layer, a heating layer, a traditional Chinese medicine layer and an inner cotton cloth layer from outside to inside. The external use pharmaceutical composition compress bag can be used for household treatment and breast health care.

The invention relates to a process for obtaining an amphotericin B (AmB) formulation in liposomes containing dicetyl phosphate (DCP), based on incorporation of the drug into the membrane of preformed liposomes, combining the effects of pH on the solubility of amphotericin B and of temperature on the insertion of the drug into the liposome membrane. The technology also relates to use of the process and of the formulation for the manufacture of medicaments for the treatment of leishmaniasis and sporotrichosis, for oral or topical administration.

The invention provides a local external medicine composition for treating acne as well as a preparation method and application of the local external medicine composition. The pharmaceutical composition disclosed by the invention is prepared from ozlafloxacin, adapalene, a solubilizer, a surfactant and a solvent, wherein the solubilizer is an alcohol compound and / or an ester compound, the hydrophilic-lipophilic balance value of the surfactant is 20-30, and the pH value of the pharmaceutical composition is 4s < 10 >. According to the pharmaceutical composition disclosed by the invention, the ozlafloxacin and adapalene can be effectively released, and in a stability experiment, the content of the ozlafloxacin and adapalene can be kept stable, obvious degradation does not occur, and the particle size distribution is not obviously changed.

This invention belongs to the technical field of skin disease treatment products, specifically relating to a topical hot compress for treating scleroderma and its preparation method. The topical hot compress for treating scleroderma is made from the following raw materials in parts by weight: 20-40 parts of Artemisia argyi, 20-40 parts of Cinnamomum cassia, 10-20 parts of Sparganium stoloniferum, 10-20 parts of Curcuma zedoaria, 10-20 parts of Loranthus parasiticus, 15-30 parts of Gynostemma pentaphyllum, 10-20 parts of Spirodela polyrhiza, 15-30 parts of Spirodela polyrhiza, 15-30 parts of Ephedra sinica, 20-40 parts of Clematis chinensis, 5-15 parts of Eupolyphaga sinensis, 15-25 parts of Eriocaulon buergerianum, 5-15 parts of Carthamus tinctorius, 3-6 parts of Dracaena cochinchinensis, 3-6 parts of processed Strychnos nux-vomica, 20-40 parts of Vaccaria segetalis, 20-40 parts of Astragalus membranaceus, 10-20 parts of Magnolia officinalis, 10-20 parts of Aconitum carmichaelii, and 22-40 parts of rice wine. This invention is a topical medication that eliminates the need for oral administration, treating the disease externally and guiding the pathogenic factors to a cure. It avoids the inconvenience of bitter medications and effectively relieves symptoms and promotes the cure of localized scleroderma.

The present invention relates to the technical field of polysaccharide material modification, and specifically relates to a high-viscoelastic crosslinked biopolysaccharide gel, a preparation method therefor, and an application thereof. After a carboxyl-group-containing biopolysaccharide and a diaminodiketopiperazine-based crosslinking agent are dissolved and mixed uniformly, a crosslinking reaction is generated under the action of a condensing agent to obtain a high-viscoelastic crosslinked biopolysaccharide gel; following moist heat sterilization, the resulting high-viscoelastic crosslinked biopolysaccharide gel meets conditions for the application thereof, and can be applied to the preparation of injectable formulations, internal filler formulations, or topical pharmaceutical carrier formulations. The crosslinked biopolysaccharide gel prepared according to the present invention exhibits large headroom, in terms of viscoelasticity data, to accommodate moist heat sterilization, which ensures product sterility while guaranteeing the product has good viscoelastic performance, with low cytotoxicity, high product purity, and long service life.

The application discloses a medicine composition for promoting wound healing and a preparation method and application thereof. The medicine composition comprises the following components in parts by weight: 1-10 parts of hemoglobin molecules, 1-5 parts of lipoic acid, 0.1-1 part of acetylcysteine, and 40-80 parts of a solvent; the hemoglobin molecules comprise at least one cysteine part and at least one histidine part, wherein the cysteine part comprises an acetyl group or an ethyl maleoyl group, and the histidine part comprises a benzimidazole derivative group. The application applies lipoic acid and acetylcysteine to the external medicine composition of the hemoglobin molecules modified by acetyl groups or ethyl maleoyl groups in combination, effectively relieves the irritant reaction caused by the hemoglobin modification to the skin through the synergistic antioxidant and tissue protection effects, and thus improves the safety and applicability of the medicine composition in skin wound treatment, and the medicine composition is suitable for treating multiple types of wounds such as external injuries, burns, postoperative wounds and ulcer wounds.

The invention discloses an external pharmaceutical composition for treating nasal obstruction and running nose and a preparation method of the external pharmaceutical composition, and relates to the technical field of medicines. The traditional Chinese medicine composition is mainly prepared from the following raw materials in parts by weight: 5-15 parts of (peeled) cassia twigs, 5-15 parts of honey-fried licorice roots, 1-5 parts of (raw) pinellia ternate, 6-15 parts of kudzuvine roots, 5-10 parts of inula flowers, 5-10 parts of ligusticum wallichii, 5-10 parts of tussilago farfara and 3-10 parts of mangnolia officinalis. The preparation method comprises the following steps: S1, respectively weighing the raw materials in parts by weight; s2, mixing and grinding the raw materials weighed in the step S1 into powder; s3, sieving, and removing medicine residues to obtain medicine powder; s4, packaging the medicine powder into bags. The medicine composition can improve the environment of the nose and effectively remove pathogenic bacteria and viruses of the nose, and is effective for nasal obstruction and running nose, acute rhinitis and chronic rhinitis caused by wind-cold and wind-heat in the early stage.