406 results about "Topical medication" patented technology

I have discovered cosmetic or topical pharmaceutical compositions for external body part or organ slimming, firming, cellulite reduction, fat-reduction, and obesity control benefits that are in synergistic combination with benefits for the treatment of skin aging, skin wrinkles reduction, skin exfoliating, treatment of acne, treatment of rosacea, age-spots reduction, skin surface whitening, skin surface brightening striae distensae (stretch marks) reduction, treatment of pimples, treatment of skin infections and lesions, spider veins reduction, blood microcirculation (venous insufficiency) improvement, UVA / UVB protection of skin, and skin redness reduction. These compositions thus provide multiple combinations of skin and external body part or organ enhancement benefits that can be selective and specific for external body parts and organs such as face, chin, cheeks, arms, "love handles" in abdomen area, eye lids and eye zone, neck, breasts, thighs, and hips. These compositions include a body beneficial composition selected from certain nutraceutical, cosmetic, and pharmaceutical ingredients, a composition to promote collagen and elastin synthesis in the skin, and a cosmetically or pharmaceutically acceptable delivery system.

A wound shield may include a conformable frame to circumscribe a wound. Any suitable dressing may be secured over the conformable frame providing separation between the wound and the dressing. The wound frame may provide pressure relief around a wound or pressure sore to permit healing, allow compression for venous ulcers, retain moisture within the wound environment, absorb exudate, relieve pain and trauma associated with dressing removal, allow debridement and application of topical medications and or other compounds or chemicals, accelerate healing and facilitate monitoring of wounds. A conformable frame may be composed of one or more layers of any suitable material and may include adhesive on one or more surfaces to secure the frame to the wound site, to secure the frame to itself and or any suitable closure element and or to secure the dressing to the conformable frame. A wound shield may be used for humans or any suitable animal.

A self-contained, conveniently disposable percutaneous absorptive patch of the present invention utilizes, in a novel ways, the existing percutaneous absorptive principles to delivering topical medications quickly, painlessly, and effectively through the skin barrier. The absorptive principles include the epidermal microcuts / micro-needles, permeation enhancers, and micro-current iontophoresis. Most importantly, the transdermal absorptive patch of the present invention introduces a novel incorporation of self-producing micro-electrical currents and micro-electrodes into the existing conventional iontophoretic principle.

The biological chitosan-gelatin-polyvinyl alcohol hemostatic dressing is compounded with chitosan, gelatin, polyvinyl alcohol and glycerin, and is prepared into hemostatic cotton, spray and other externally applied medicine forms via conventional production process. The present invention has high adsorption amount, maintained amount, no toxicity, easy absorption by body and high hemostatic function and is superior to available hemostatic dressing.

The topical medicament gel formulation of the present invention includes an anesthetic, an anti-microbial, an oxidant, a nutrient, a diuretic, an opioid, an anti-emetic, an anti-seizure drug, and a non-steroidal anti-inflammatory drug (NSAID), USP in a molecular, as opposed to a salt form, as the active ingredient. Additional constituents illustratively include a skin penetration enhancer and a gelling agent. This invention deals with problems commonly associated with topical application of local medicaments such as: slow onset of action; need for occlusion; and rapid loss of effect due to rapid systemic dispersion. The invention permits enhanced penetration of the medicament and thereby allows for a lesser total dosage of pharmaceutically active ingredient. The use of a lesser total dosage also decreases systemic toxicity.

A pouch containing a non-pressurized post-foaming gel, wherein the gel within the pouch is enclosed within an inert atmosphere, such as a nitrogen blanket, which protects the gel and prevents premature foaming and the separation of the gel's components. Upon opening the pouch and discharging the contents, the heat of the user's skin allows a low boiling point hydrocarbon, such as isopentane, to cause the gel to foam, thus providing the consumer with an instant benefit which could include cleansing, moisturizing, increasing shave comfort, wound treatment, etc. Further, the process to produce a gel which is suitable for use in a single use delivery system involves the steps of containing the gel in a jar, spraying the gel with nitrogen to remove the air from the jar, and then swirling the jar to form a non-aerated gel without weight variation problems.

The present invention is directed to pulverulent mixtures comprising hydrogen peroxide and hydrophobized, pyrogenically prepared silicon dioxide powder, preferably with a methanol wettability of at least 40. The pulverulent mixtures exhibit good storage stability and can be used for the controlled release of hydrogen peroxide and / or oxygen. The invention also includes methods of making these pulverulent mixtures and methods of using the mixtures in detergents, cleaning compositions, topical medications, antimicrobials and other products.

This invention relates to a method of treating otitis externa, and in particular otitis externa of fungal etiology, using topical medication, including antifungal agents such as, for example fluconazole, voriconazole, itraconazole, clotrimazole, amphotericin B, caspofungin (Cancidas®), micafungin (Mycamine®), terbinafine, naftifine, butenafine, amorolfine, ravuconazole, posaconazole, flucytosine, econazole, enilaconazole, miconazole, oxiconazole, saperconazole, sulconazole, terconazole, tioconazole, nikkomycin Z, anidulafungin (LY303366), nystatin, pimaricin, griseofulvin, ciclopirox, haloprogin, tolnaftate, and undecylenate.

This invention relates to a method of treating otitis externa, and in particular otitis externa of fungal etiology, using topical medication, including antifungal agents such as itraconazole and miconazole, and optionally also including a second antifungal agent, which is formulated for topical application to the external ear canal, preferably as an ear drop in liquid form.

A topical medicament for the treatment of psoriasis comprises metallic iodine, virgin wax, a variety of oils of animal and plant origin, camphor, chlorophyll and benzoic acid in a pharmaceutically acceptable emollient excipient base.

A multi-dose, metered dispenser and applicator for topical medications includes inner and outer cylinders and a plurality of expanding bases. These bases form part of a telescopic piston drive system that advances the main piston through the inner cylinder, in accordance with a selected dosage, to dispense a metered amount of the topical medication. The dosage may be selected by a switch located on an outside of the outer cylinder, and dispensed by rotating the inner cylinder relative to the outer cylinder. A tactile and audible feedback mechanism informs the user that the desired dosage of medication has been dispensed.

New topical medicaments are provided. The medicaments comprise menthol and camphor, preferably provided as part of a base gel, supplemented with potassium and a source of oxygen. The most preferred base gel is sold under the name SOMBRA, while the most preferred source of oxygen is a chlorite (e.g., sodium chlorite) and / or spirulina. The medicaments provide high metabolic activities and sustain those activities over prolonged periods of time, thus being useful for treating a large variety of ailments, including diabetic neuropathy, post hepatic neuralgia, scleroderma, psoriasis, strain, spasticity, headaches, neuropathy secondary to drugs, peripheral neuropathy, leg pain, muscle cramps, muscle aches and pains, bruise, sinusitis, sprain, arthritis, joint pain (arthralgia), and edema.

The present invention provides novel compositions which comprise sodium hypochlorite, sodium, chloride, both organic and inorganic trace minerals in hypertonic condition presented in the forms of a clear aqueous solution (low or high concentrations for further reconstitution with purified water to obtain the final ready-to-use solution), gel or salve, lotion, wet pad, wet foam, ointment, stick, and dry mixture solution, for local application for the purposes of cleansing, disinfecting and inhibiting infection and promoting the natural healing of conditions such as fresh cuts, surgical stitches, chronic (diabetic gangrene) and acute wounds, herpes zoster, athlete's foot, and bed sores, without the necessity for covering up the wounds with gauzes / plasters nor any concurrent use of topical medication. These compositions are also suitable for the treatment of conditions such as unpleasant body odor, acne and mixed bacterial infection in the ear.

The invention discloses a traditional Chinese medicinal composition for treating the qi and blood deficiency blood stasis type diabetic feet. The symptoms of the qi and blood deficiency blood stasis type diabetic feet are common in the restoration stage of the diabetic foot disease, and comprise lasting wound disunion, dilute fester, amyotrophy and weakness light tongue nature, thin and white tongue fur, chest distress, purple face, body fatness, feebleness, encrusted affect foot skin, ecchymosis, stiffness, numbness and the like. The composition comprises oral medicines and external medicines, wherein the oral medicines comprise Rhizoma Corydalis, Radix Rehmanniae Preparata, Chinese angelica, Radix Astragali, Achyranthes bidentata, Salvia miltiorrhiza, prepared Polygonum multiflorum Thunb, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix Curcumae Aromaticae, safflower, Ligusticum wallichii, Millettia dielsiana, lumbricus, dendrobium, ground beetle, Chinese cassia, Semen Brassicae and Radix Paeoniae Rubra; and the external medicines comprise Manchurian wildginger, Radix Clematidis, Panax Notoginseng, Boswellia carteri, myrrh, rheum officinale, Amur Corktree Bark, dried alum, Glabrous Greenbrier Rhizome, fried Radix Sanguisorbae, safflower, Fructus Cnidii, Bletilla striata and Rhizoma Drynariae. The composition has the efficacies of qi and blood tonifying, channel freeing and blood circulation stimulating, channel warming and cold dispelling, stasis removing and pain relieving, qi and blood benefiting, and internal heat and dysphoria removing when the composition is orally taken, and has the efficacies of blood circulation activating, stasis removing, inflammation removing and flesh engendering when the composition is externally used. On one hand, the local micro-vascular impairment of the lower limbs is improved and the blood circulation is promoted to make necrotic tissues shed as fast as possible in order to reach tissue restoration; on the other hand, the oral medicines can effectively control the blood sugar, adjust the blood viscosity and reduce the blood pressure; and simultaneously the food infection is prevented to enhance the body immunity.

The present invention discloses preparation process and use of Chinese paris rhizome total saponin as the effective component. The preparation process of the present invention is one simplified one comprising alcohol extraction, water precipitation, and deionized water washing and depositing. The preparation process has lowered alcohol consumption, obviously reduced production cost, no use of acetone, high effective component yield, high product purity and stable quality. The present invention also relates to the application of Chinese paris rhizome total saponin in preparing externally applied medicine for diminishing inflammation, eliminating swelling and relieving pain, antiviral medicine, and anti-tumor medicine.

An exterior-applied Chinese medicine for treating bone fracture, dislocation, joint sprain, hyperosteogeny, rheumatic arthritis, and soft tissue injury is prepared from 44 Chinese-medicinal materials including notoginseng, Sichuan aconite root, Chuan-xiong rhizome, myrrh, etc. Its advantages are high curative effect and high safety.

The invention relates to a compound preparation of an external use pharmaceutical composition for treating swelling and pain, which is a gel binder for treating swelling, and also provides its preparation method. The gel binder is prepared by 20-50% of swelling and pain medicine of the external use pharmaceutical composition for treating swelling and pain as well as proper pharmaceutical excipients. The gel binder for treating swelling is composed of a back lining layer, an ointment-containing body and a cover lining layer. The ointment-containing body, namely the kernel part, is prepared from the swelling and pain medicine, a basic polymer, a cross-linking agent, an organic acid, an excipient, a humectant, an adhesive and the like in certain ratio. The gel binder has the advantages of fast effect, good moisture preservation, high permeability and comfortable use. The product has merits of convenient usage, small irritation on skin and high compliance of patients.

The invention discloses an external-use medicine composition of traditional Mongolian medicines for curing soft tissue injuries, which is prepared from the following medical ingredients in parts by weight: 500-570 of Mongolian sorrel, 500-570 of carthamus tinctorius, 500-700 of pseudo-ginseng, 200-300 of oxytropis myriophylla, 300-450 of terminalia chebula, 200-300 of gypsum, 300-450 of talc powder, 125-188 of borneolum, 160-240 of menthol, 100-150 of camphor, 80-120 of methy salicylate and 0-51 of thymol. In addition, the invention also discloses the preparation method, a quality control method and application of the external-use medicine composition of traditional Mongolian medicines.

Anaphylactic diseases comprising urticaria, papilla, subacute dermatitis, eczema, and the like, are skin diseases which seriously puzzle the human beings. In the invention, antihistamine, zinc salt and weak acid are prepared into a topical compound preparation, which not only reduces the untoward effect of drugs, avoids the first pass effect of the liver when feeding the drugs by mouth, avoids the blood concentration peak valley phenomenon caused by oral feeding, but also can improve the curative effect and is convenient for clinic application. Simultaneously pharmacological tests show that the topical compound preparation obtains excellent drug synergism to the anaphylactic skin diseases and has excellent effects on curing the anaphylactic diseases.

The application describes a convenient portable kit for the application of topical medications. The kit can be used, for example, as a convenient system for application of cold sore medication. The kit includes a container for a quantity of fluid medication sufficient for several treatments together with a plurality of applicators for said medicine. The applicators are specially designed to apply the medicine accurately and with minimal pain.

The invention discloses a soluble microneedle for promoting hair growth. The microneedle comprises a base, a soluble polymer needle body located on the base and a needle tip carrying a hair growth promoting substance. The invention discloses a preparation method of a soluble microneedle for promoting hair growth. The preparation method comprises the following steps: 1) preparing a PDMS microneedlearray mold; 2) preparing a soluble polymer aqueous solution containing substances for promoting hair growth; and 3) preparing the soluble polymer microneedle array loaded with the substance for promoting hair growth, which can solve the technical problems of low transdermal rate, non-uniform distribution, pain in the subcutaneous injection process of interleukin 2, large side effect of a finasteride oral administration mode and high hair transplantation price of the existing external medicine.

The invention discloses new application of arginine, which is the application of arginine or a pharmaceutically acceptable salt, an ester or a mixture of the salt and the ester in preparing topical pharmaceutic preparations with at least one of the following effects: (1) treating and / or facilitating wound healing, and (2) reducing scar formation. Results in pharmacodynamics experiments show that the external use of L-arginine can remarkably facilitate trauma healing of rat skin as well as reduce the area of a wound scar. Arginine not only can be used for treatment and healing of traumas but also can be used for other skin diseases, including a pressure ulcer (bedsore), skin injuries caused by dermatitis, scald, burn and the like.

The invention relates to an external use drug or health product, in particular to an external use drug capable of improving microcirculation, clearing and activating channels and collaterals, promoting blood circulation removing stasis and treating rheumatism bone diseases and a preparation method of the external use drug. The method comprises the steps of taking and cutting the four traditional Chinese medicinal materials of saposhnicovia divaricate, radix angelicae pubescentis, longspur epimedium and caesalpinia sappan into segments with the length ranging from 10 mm to 15 mm, mixing liquidambar formosana hance, rhizoma atractylodis, angelica sinensis, folium artemisiae argyi, suberect spatholobus stems, polygonum cuspidatum, eucommia ulmoides, cassia twig and flos carthami with the four traditional Chinese medicinal materials, placing the mixture into a heat reflux extraction tank, adding water for soaking for 1 h, conducting heating reflux extraction for 5 h, concentrating the mixture to until the density ranges from 1.15 to 1.20, conducting drying at the temperature of 80 DEG C, smashing the mixture into fine powder, placing the fine powder into a granulator for granulation, drying the wet granulates, controlling the temperature to range from 40 DEG C to 50 DEG C for 2 min to 3 min, placing the dried granulates into an oscillating granular to be granulated with a 16-mesh screen cloth, and packaging the granulates to obtain the external use drug. The external use drug has the health care function, improves microcirculation, is applicable to people who have waist, leg, shoulder and neck joint pains caused by rheumatism strains and have microcirculation disturbance caused by hyperostosis.

The invention belongs to the technical field of medicines, and relates to a sebum liposome and a preparation method of the same. The sebum liposome comprises ceramide, phospholipid, free fatty acids and cholesterol, wherein the ceramide is a corn extract, namely, corn ceramide, the phospholipids is soya bean lecithin, and the free fatty acids comprise palmitic acid, linoleic acid and oleic acid; the molar ratio of the ceramide to the phospholipid is (1:1)-(9:1), and preferably 2: 1; and the molar ratio of the ceramide or the phospholipid to cholesterol is not greater than 1 / 3, and preferably not greater than 1 / 5. A novel medicine-loading system for the sebum liposome is put forward for the first time; and the system can be used for external preparations, has the advantages of being high in medicine-loading capacity and good in stability, as well as is high in affinity with the skin, and capable of reducing the irritation of the external preparations, enhancing the union of the broken skin, and providing a better application prospect for the external medicine preparations.

The invention relates to an injectable parenteral medicinal preparation of temozolomide and a preparation method thereof. The medicinal preparation comprises (1) temozolomide or pharmaceutically acceptable salt thereof, (2) at least one stabilizer, and (3) at least one aqueous diluent, wherein the stabilizer is selected from L-alanine, L-glycine, L-cysteine, L-cysteine hydrochloride anhydride, L-cysteine hydrochloride monohydrate, acetyl cysteine, S-carboxymethyl-L-cysteine, L-ethyl cysteine hydrochloride, L-methyl cysteine hydrochloride, vitamin C or a mixture thereof. The invention further relates to lyophilized power containing the medicinal preparation and products thereof.

A chemical compound and a method for its use as a topical medication that can reverse the effects of sun-damage, reverse the signs of aging, demonstrate anti-scarring properties and allow for the treatment of acne while still permitting the patient the ability to simultaneously expose the affected area to the sun without damage that includes a combination of curcumin, water, alcohol, cellulose, anti-inflammatory agent, carbomer, diazolinyl urea, triethanolamine, EDTA and an acidic component that maintains the optimal pH of between 4.5 and 5.5

The invention discloses a traditional Chinese medicine for treating the bedsore through oral administration and external washing and a preparation method of the traditional Chinese medicine, and belongs to the technical field of traditional Chinese medicines. A medicine for oral administration is prepared from the following raw materials: platycodon grandiflorum, ligusticum wallichii, radix angelicae, endothelium corneum gigeriae galli, ginseng, costustoot, fructus aurantii, root of common peony, radix paeoniae alba, angelica, dried orange peels, root of red-rooted salvia, coptis chinensis, astragalus membranaceus, medlar, codonopsis pilosula, bighead atractylodes rhizome, semen cuscutae, caulis spatholobi, safflower carthamus, liquorice, frankincense, alum, mint, schizonepeta, myrrh, dragon's blood, semen brassicae, polygonum cuspidatum, golden cypress, radix sophorae flavescentis, calcined gypsum and borneol. The medicine for oral administration has a synergistic effect and has the effects of clearing heat and toxic materials, benefiting vital energy, dredging collaterals, nourishing blood, moistening the skin, healing sore and promoting tissue regeneration; a medicine for external use can be used for directly reaching a nidus, quickly expanding blood vessel and promoting local blood circulation to achieve the effects of promoting blood circulation to remove blood stasis and removing necrotic tissue to promote tissue regeneration. According to the traditional Chinese medicine, the effect of treating both symptoms and root causes of the bedsore can be achieved.