97 results about "Vaginitis" patented technology

The invention relates to lactobacillus gasseri FMTA1121E with an effect of regulating a vaginal micro-ecological environment and application of the lactobacillus gasseri FMTA1121E. The lactobacillus gasseri FMTA1121E is classified and named as lactobacillus gasseri, and the preservation number of the lactobacillus gasseri FMTA1121E is CGMCC No.34962. The lactobacillus gasseri FMTA1121E can be metabolized to generate beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide so as to regulate the genital tract environment and improve the health degree; and the bacillus subtilis has excellent bacteriostasis and sterilization effects on various common vaginal pathogenic bacteria such as escherichia coli, staphylococcus aureus, gardnerella vaginalis, candida albicans, neisseria gonorrhoeae and the like. Therefore, the lactobacillus gasseri FMTA1121E strain can be applied to preparation of preparations for preventing and treating related genital tract diseases such as vaginitis.

The invention discloses a lactobacillus acidophilus FMM01 with the effects of improving the contractility of pelvic floor muscles and repairing mucous membranes and application of the lactobacillus acidophilus FMM01, the lactobacillus acidophilus FMM01 is preserved in the China Center for Type Culture Collection, the preservation date is January 9, 2024, and the preservation number is CCTCC NO: M2024052. The lactobacillus acidophilus FMM01 has the advantages of self-adaption, high acid resistance, strong mucous membrane adhesiveness and no irritation to vaginal mucosa. The lyophilized powder is high in activity and excellent in stability; experimental results show that the lactobacillus acidophilus FMM01 can effectively inhibit bacteria, and especially can effectively inhibit enterobacter cloacae, vibrio parahaemolyticus and / or candida albicans. Besides, the lactobacillus acidophilus FMM01 can improve vaginal relaxation, improve pelvic floor muscle contractility and / or recover vaginal mucosa functions, can promote recovery of healthy florae after mixed vaginitis antibiotic / hormone treatment, improves the treatment effect of mixed vaginitis, and remarkably reduces the recurrence rate of mixed vaginitis.

The invention relates to the technical field of biology, in particular to leukocyte esterase detection test paper and a preparation method thereof. Based on the principle of a substrate and a color developing agent, the color developing depth is in direct proportion to the concentration of the esterase, so that the concentration of the leukocyte esterase in a detection sample can be judged according to the color developing depth; meanwhile, under the auxiliary action of calcium chloride and other materials, the detection distinction degree, the detection accuracy and the detection result stability are further improved. The leukocyte esterase test paper provided by the invention is simple in sample detection method, more stable in product performance, longer in validity period and wide in application range, can be used as an auxiliary evaluation index for vagina inflammation, and is combined with a cleanliness index and the like to jointly evaluate the vagina environment.

The invention provides a novel application of L-beta-galactoglucan, and particularly provides an application of the L-beta-galactoglucan in the aspect of resisting vaginitis.

The application discloses an active oxygen response type bacteriostatic and repair promoting hydrogel and a preparation method and application thereof, the hydrogel is formed by disulfide bond cross-linked hydrogel in response to active oxygen free radicals in the vagina of vaginitis patients through thiol modified hyaluronic acid (HASH), and can enhance in-vivo retention by thiol and vaginal tissue interaction. Cationic surfactant such as didecyldimethylammonium chloride (DDAC) as the bacteriostatic component of the hydrogel, efficiently killing pathogenic bacteria while having good biocompatibility, and is not prone to cause bacterial drug resistance. As a natural immune regulator, beta-glucan regulates the vaginal microenvironment, promotes the polarization of macrophages into anti-inflammatory M2 type and promotes cell migration, etc., to promote the repair of the vaginal immune barrier, regulate the vaginal flora, and reduce the probability of vaginitis recurrence. The HASH hydrogel provides an efficient, convenient and highly transformative potential strategy to provide more choices for the treatment of vaginitis.

The application belongs to the technical field of microorganisms, and particularly relates to two strains of lactobacillus plantarum PB12 and PB14 and application thereof in preventing or treating female vaginitis. lactiplantibacillus plantarum The application discloses two strains of lactobacillus plantarum (Lactobacillus plantarum), namely lactobacillus plantarum PB12 and lactobacillus plantarum PB14. The application also discloses application of the two strains of lactobacillus plantarum in preparing medicines or products for preventing and / or treating female vaginitis, including inhibiting growth of Candida albicans and relieving inflammation of a genital tract.

To provide compositions and methods for detecting bacterial nucleic acids and diagnosing bacterial vaginosis.SOLUTION: Disclosed is a method for diagnosing bacterial vaginosis in a subject comprising performing an assay to detect one or more of Lactobacillus spp., Atopobiumvaginae, and Gardnerallvaginalis in a sample of the subject. Also disclosed are compositions and methods for detecting Lactobacillus spp., Atopobiumvaginae, and / or Gardnerallvaginalis nucleic acids in a sample.SELECTED DRAWING: None

The invention relates to the field of prevention and treatment of vaginitis, in particular to a composition of lactobacillus rhamnosus LRa05, lactobacillus acidophilus La88 and lactobacillus plantarum Lp90 and application of the composition to regulation of vaginal mucosa barrier protein. The lactobacillus rhamnosus LRa05 is a lactobacillus rhamnosus LRa05 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) NO.24377, and the lactobacillus rhamnosus LRa05 is a lactobacillus rhamnosus LRa05 with the preservation number of CGMCC NO.24377. The lactobacillus acidophilus La88 is the lactobacillus acidophilus La88 of which the preservation number is CGMCC (China General Microbiological Culture Collection Center) NO.24109, and the lactobacillus acidophilus La88 is a lactobacillus acidophilus La88 of which the preservation number is CGMCC NO.24109. The lactobacillus plantarum Lp90 is the lactobacillus plantarum Lp90 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) NO.10453, and the lactobacillus plantarum Lp90 has the preservation number of CGMCC NO.10453. The lactobacillus rhamnosus LRa05, the lactobacillus acidophilus La88, the lactobacillus plantarum Lp90 and the combination thereof disclosed by the invention can regulate the expression of the vagina mucosal barrier protein.

The invention relates to fermented lactobacillus mucus FMTA1124J with the function of improving the health degree of female genital tracts and application of the fermented lactobacillus mucus FMTA1124J. The classified name of the fermented lactobacillus mucus FMTA1124J is Limosilicilla fermentum, and the preservation number of the fermented lactobacillus mucus FMTA1124J is CGMCC No.34963. The fermented lactobacillus mucus FMTA1124J can produce beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide through metabolism so as to adjust the environment of the genital tracts and improve the health degree; and the traditional Chinese medicine composition has good bacteriostasis and sterilization effects on common vaginal pathogenic bacteria such as Escherichia coli, staphylococcus aureus, Gardneria vaginalis and Candida albicans. Therefore, the fermented lactobacillus mucus FMTA1124J strain can be used for preparing a preparation with the effect of improving related genital tract diseases such as vaginitis.

The application discloses application of a traditional Chinese medicine composition in preparation of a medicine for treating vaginitis, and preparation raw materials of the traditional Chinese medicine composition include zedoary turmeric and Chinese atractylodes rhizome. The traditional Chinese medicine composition can kill common pathogenic bacteria of vaginosis, and has good bacteriostatic effect. While inhibiting the common pathogenic bacteria of vaginosis, the traditional Chinese medicine composition does not inhibit lactobacillus of vagina. The traditional Chinese medicine composition can not only kill single common pathogenic bacteria of vaginosis, but also relieve trichomonas vaginalis, and inhibit mixed infection of bacteria and fungi.

Disclosed herein are compositions and methods of manufacturing, testing, and using a biocompatible and disposable vaginal suppository, comprising chitosan, collagen, carboxymethyl cellulose, and an enzyme, capable of breaking down vaginal mucous and releasing the active ingredients consistently over extended periods of time. Methods disclosed herein may also include the use of these compositions, methods, and devices for treating vaginal diseases, such as vaginitis, genitourinary syndrome, and other conditions, such as vulvar and vaginal cancer, or cervical cancer.

The invention patent is titled "Dragon and Cypress Gel," belonging to the pharmaceutical category. The main components of Dragon and Cypress Gel are: Phellodendron bark, earthworm, dragon's blood, Oldenlandia diffusa, Sophora flavescens, and Bletilla striata. In recent years, research on cervicitis and cervical lesions has shown good results using external treatments of traditional Chinese medicine. Vaginal cervical medications are characterized by high local drug concentration, low dosage, and safety and effectiveness, receiving high clinical evaluation. The vagina and cervix have abundant capillaries and lymphatic vessels, and lack clearly defined nerve endings, resulting in minimal pain stimulation for patients during administration. This makes it an effective drug release site for specific diseases such as cervicitis and vaginitis. Traditional Chinese medicine gels are a novel type of external preparation of traditional Chinese medicine. They are made by dissolving or uniformly dispersing traditional Chinese medicine in a gel. These gels adhere tightly to the treatment site for a relatively long time, exhibiting good bioadhesion, and are simple to prepare. It is suitable for use on skin, mucous membranes and cavities. It not only avoids the first-pass effect of enzymes and acids in the gastrointestinal tract that exists in oral administration, but also reduces the adverse reactions of drugs. It has the characteristics of good spreadability, non-greasy feeling, easy to wash off, good transdermal absorption, and comfortable use.

The invention discloses a self-detection device for vaginitis, and belongs to the technical field of medical instruments, the self-detection device for vaginitis comprises a sampling cotton swab and a detection card, and further comprises a vaginal dilation assembly and a diluent containing assembly, the sampling cotton swab is movably inserted in the vaginal dilation assembly, the vaginal dilation assembly is detachably connected with the diluent containing assembly, and the detection card is connected with the sampling cotton swab. A connecting through hole corresponding to a cotton swab head of the sampling cotton swab is formed in the diluent containing assembly. The vagina expanding assembly can achieve the vagina expanding effect, and the cotton swab head can be cut off through contraction of the vagina expanding assembly after cotton swab sampling is completed, so that the cotton swab head can be rapidly soaked in a diluent, and a detection card can be conveniently used for detection. Besides, a sampling operation disc is arranged at the rear end of the cotton swab, a limiting assembly is arranged between the sampling operation disc and the vagina expanding assembly, the cotton swab can be fixed when the cotton swab is cut off, operation of a patient is facilitated, and it is guaranteed that the cotton swab can just fall into the diluent from a through hole in the diluent containing assembly.

The invention relates to the technical field of gynecological medical instruments, in particular to a medicine auxiliary device for treating vagina inflammation. The medicine taking auxiliary device for treating vagina inflammation comprises a box body, a controller, universal wheels, a handle, a medicine discharging mechanism and a medicine applying mechanism, the controller is installed at the top of the box body, the handle is connected to the top of the box body, the universal wheels are installed at the four corners of the bottom of the box body, and the medicine discharging mechanism and the medicine applying mechanism are arranged in the box body. Liquid medicine in the medicine cylinder is pumped out through the liquid pump, the liquid medicine flows through the medicine applying grab handle through a pipeline and then flows into the medicine applicator, then the first motor drives the transmission gear to rotate and the medicine applicator to rotate, and the liquid medicine flows out of the uniform medicine outlets in the medicine applicator and is uniformly applied to the vagina of a patient; the medicine liquid in the vagina of a patient is uniformly applied through the spiral convex lines on the applicator, so that the medicine liquid can play a better role, and the treatment effect is improved.

The application provides an LED optical therapeutic instrument for treating vaginitis, and relates to the technical field of optical therapeutic instruments, which comprises a moving cylinder, a battery box is fixed to the tail end of the moving cylinder, and the front end of the moving cylinder is provided with an opening, a pushing assembly is arranged in the moving cylinder, the pushing assembly comprises a front pipe, an intermediate pipe is arranged at the rear end of the front pipe, a rotating shaft is arranged between the front pipe and the intermediate pipe, a connecting layer is fixed to the tail end of the moving cylinder, a second screw rod is screw-connected in the connecting layer in a threaded manner, one end of the second screw rod is rotationally connected with the intermediate pipe through a bearing, and a mounting assembly is arranged at the bottom of the outlet end of the moving cylinder, through the unfolding of the inner supporting plate, the position of the disease is observed conveniently, the front pipe provided with a medicinal suppository is moved to the position through the pushing assembly, the medicinal suppository is applied to the position to be treated through the rotation of the rotating shaft, the position deviation is avoided, the sterilization and disinfection are concentrated through the irradiation of the irradiation lamp, and the treatment effect is improved.

The utility model discloses a kind of medicine applying devices for gynaecology vaginitis, belong to gynaecology medical instrument technical field, a kind of medicine applying device for gynaecology vaginitis, including push plate, push plate front end is fixedly connected with medicine applying structure, medicine applying structure inside is threadedly connected with injection structure, push plate rear end is fixedly connected with limit ring, push plate inner surface and limit ring inner surface are threadedly connected with push structure, it is cooperated by medicine applying structure and push structure, when gynaecology doctor treats vaginitis patient, capsule, tablet and powder drug can be quickly sent into patient vagina, complete medicine applying, by injection structure and medicine applying structure and push structure cooperation, so that device can also complete liquid medicine applying, eliminate limitation, by push structure, so that the controllability of device is higher, can effectively avoid to cause harm to the inside of patient's vagina, can realize the function of convenient liquid medicine and high operating precision, improve the practicality of device.

The invention discloses skin mucosa maintenance liquid capable of killing fungi and HPV (human papillomavirus) as well as a preparation method and application of the skin mucosa maintenance liquid, and belongs to the technical field of sterilization and virus removal. The skin mucosa maintenance liquid is prepared from octanol ether, benzalkonium bromide, phenoxyethanol, yermate, parachlorometaxylenol, taetinic acid, chitosan, keratinase, fluconazole, glycerol, borneol, menthol, absolute ethyl alcohol and tween-40. Wherein the skin mucosa maintenance liquid has an effect of regulating apoptosis induction on abnormal cells and an effect on vaginal flora, and has an obvious inhibition effect on cervicitis and colpitis mycotica, namely an anti-inflammatory effect; meanwhile, apoptosis of cells containing HPV16 and HPV18 genes can be induced, shedding of abnormal cells is promoted, diseased cells are killed, and vaginal tissues with pathological changes are removed.

The application relates to an intelligent diagnosis method for cervical cell atrophy levels, and relates to the problem that intelligent discrimination of cervical cell atrophy degrees is lacking in automatic pathological diagnosis technology. Cervical vaginal squamous epithelium is divided into surface layer cells, middle layer cells and basal layer cells, and ovarian estrogen affects the growth and maturity of the cells; a decrease in estrogen level can cause symptoms such as atrophic vaginitis and osteoporosis, which need to be treated in time; at present, squamous cell atrophy diagnosis is not clear enough, and there are few reports on atrophy degree diagnosis research, so it is of great significance to establish a systematic and intelligent diagnosis process for cervical cell atrophy degree discrimination. In order to improve the problem, the application provides an intelligent diagnosis method for cervical cell atrophy levels; the method first detects the surface layer cells, the middle layer cells and the basal layer cells by using a target detection model, then segments the cell nucleus of each layer of cells detected by using an instance segmentation model, and finally calculates the cell quantity ratio, the nucleus-cytoplasm ratio and the cell crowding degree index of each layer; the indexes are input into a random forest classification model to grade the atrophy degree; it is known through sufficient experimental verification that good effects are achieved in cervical cell atrophy degree discrimination. The application is applied to cervical cell atrophy degree discrimination.

The invention relates to the technical field of probiotic application, in particular to application of lactobacillus crispatus HC1261 in preparation of a microbial agent for improving female reproductive health and a composition for improving vagina inflammation. The lactobacillus crispatus HC1261 is preserved in the China General Microbiological Culture Collection Center (CGMCC) on May 16, 2023, the preservation address is No.3, No.1 yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No.27355; the microbial inoculum for improving female reproductive health can reduce the load of the ureaplasma urealyticum in the vagina. The lactobacillus crispatus HC1261 can be used for pertinently reducing the load of the ureaplasma urealyticum in the vagina, and can be used for reducing the related health risks of urethritis, cervicitis, pelvic inflammation, infertility and the like caused by the ureaplasma urealyticum.

The invention discloses an injectable photo-crosslinking hydrogel loaded with pseudolaric acid as well as a preparation method and application thereof. The preparation method comprises the following steps: 1) respectively dissolving Gelma and HAMA in sterile PBS (Phosphate Buffer Solution) according to the dosage required by a final system; 2) mixing the two solutions, and adding a photoinitiator LAP pre-dissolved in the sterile PBS at 60 DEG C; 3) dissolving golden larch bark acetic acid in dimethyl sulfoxide to prepare a medicine solution with the concentration of 1.0 mg / mL, and then adding the medicine solution into the precursor solution under the condition of continuous stirring; and 4) carrying out 405 nm illumination crosslinking on the obtained precursor solution to form the hydrogel. The hydrogel three-dimensional network can continuously and controllably release pseudolaric acid, maintains a long-acting effective drug concentration at an infected part, shows a strong inhibition effect on a candida albicans standard strain and a clinical drug-resistant strain, and has a good application prospect in a model for treating candida vaginitis and fungal skin wound infection. And all the components show a remarkable'anti-infection-repair promoting 'integrated treatment effect.

This invention relates to the field of gene detection technology, specifically to a primer set and its application, and a training method for a bacterial vaginosis diagnostic model. The primer set, used for diagnosing bacterial vaginosis, includes specific primers for specifically amplifying target regions of the following pathogens: *Atopobacterium vaginalis*, *Gardnerella vaginalis*, *Cyclophorus 1*, *Cyclophorus 2*, *Bacterial Vaginosis-Associated Bacteria 2*, *Animal Curvularia clarithii*, *Animal Curvularia emblica*, *Prevotella 2*, *Lactobacillus curvularia*, *Lactobacillus indolentus*, *Lactobacillus gasseri*, and *Lactobacillus janniae*. This invention also provides the application of this primer set and a training method for a bacterial vaginosis diagnostic model. Using this primer set, high-throughput sequencing can be performed on test samples, simultaneously detecting 12 target pathogens, and further constructing a bacterial vaginosis diagnostic model, which can be used for the clinical diagnosis of bacterial vaginosis with good specificity and sensitivity.

The application discloses probiotics with the effect of improving vaginitis, a compound micro-ecological preparation and application thereof, and is characterized by comprising at least one of the Lactobacillus plantarum 22-9 strain with the preservation number of CGMCC No.33867, the Lactobacillus plantarum XA-9 strain with the preservation number of CGMCC No.33868 and the Lactobacillus pentosus B-1-35 strain with the preservation number of CGMCC No.33870, and the lactic acid bacteria culture of the Lactobacillus plantarum 22-9, the Lactobacillus plantarum XA-9 and the Lactobacillus pentosus B-1-35 is mixed in a volume ratio of 2:1:3, and the lactic acid bacteria fermenting agent is inoculated in a fermentation medium in a volume ratio of 1-5% to prepare the probiotic compound micro-ecological preparation, and the advantage is that the content of lactic acid bacteria in the vagina can be increased, the content of pathogenic bacteria can be reduced, the number of inflammatory cells in the vagina can be reduced, and the levels of inflammatory factors IL-1beta, IL-6 and TNF-alpha in serum can be reduced.

The invention provides a primer and a probe for detecting related pathogens of vaginitis through multiple RPA (recombinase polymerase amplification)-lateral flow immunochromatography. The primer comprises a neisseria gonorrhoeae porA gene primer pair, a gardnerella vaginalis 16S rRNA (ribosomal Ribonucleic Acid) gene primer pair, a candida albicans ITS2 gene primer pair, a trichomonas vaginalis actin gene primer pair and a ureaplasma urealyticum Urease gene primer pair. The probes comprise a gold nanoparticle binding probe, a quality control line capture probe and capture probes corresponding to the five genes. The invention also provides application of the primer and the probe in preparation of vaginitis-related pathogen detection products, and also provides a corresponding detection kit and method. According to the invention, the rapid and accurate detection of five common vaginitis pathogens is realized through the RPA-lateral flow immunochromatography technology, and the kit is suitable for rapid, early and convenient diagnosis of vaginitis patients.

The invention provides a composite spray lotion of a targeted vaginal pathogenic bacterium biological membrane and an ultrasonic infiltration promotion system. The spray lotion comprises the following components in parts by weight: 0.1-5 parts of antibacterial peptide; 10 to 100 parts of bacteriophage; 30 to 80 parts of rose water; 10 to 30 parts of betaine; 20 to 50 parts of cocamidopropyl betaine; 5 to 20 parts of lauryl glucoside; 5 to 20 parts of sodium lauroyl sarcosinate; 0.2 to 1 part of chlorhexidine acetate; and 500 to 1000 parts of purified water. The antibacterial peptide of the spray-washing liquid directly acts on extracellular polymeric substances of vagina biomembranes, the compact structure of the extracellular polymeric substances is destroyed, and a permeation channel is opened for subsequent antibacterial components; meanwhile, pathogenic bacteria in vaginal biomembranes can be directly killed, the action mechanism of the antibacterial peptide is that bacterial cell membranes are physically damaged, and the pathogenic bacteria are not prone to generating drug resistance. The components such as the rose water can relieve discomfort such as pruritus, dryness and scorching hot caused by vaginal infection or improper cleaning, and are suitable for treatment scenes such as colpitis mycotica and abnormal leucorrhea, high in safety and wide in applicability.

Disclosed are novel Lactobacillus strains, relating to a new Lactobacillus crispatus V435 strain and a new Lactobacillus jensenii V216 strain, and a composition comprising the strains used in the prevention or treatment of vaginitis. The Lactobacillus crispatus V435 strain is capable of producing lactic acid at a high yield, and the Lactobacillus jensenii V216 strain is capable of producing lactic acid and hydrogen peroxide at a high yield. Both strains have an excellent ability to inhibit clinically isolated Gardnerella, clinically isolated Atopobium, and fungi, a good ability to inhibit mixed vaginal pathogenic flora, and can be stably colonized in vaginal environments to become a dominant flora therein. The two strains exhibit a mutually beneficial symbiotic relationship without generating an antagonistic effect, and also exhibit a synergistic effect, resulting in stronger probiotic capabilities than a single dominant strain.

The utility model belongs to the technical field of medical instruments and provides a biological membrane ultrasonic destruction device which comprises an isolation protection tube, an ultrasonic generation mechanism, a power supply mechanism and a rotation driving mechanism. The ultrasonic generating mechanism comprises a mounting base which extends into the isolation protection pipe and can rotate in the circumferential direction and a piezoelectric element arranged on the mounting base, the ultrasonic generating face of the piezoelectric element is perpendicular to the cross section direction, the power supply mechanism is used for supplying power to the piezoelectric element, and the rotation driving mechanism is used for driving the mounting base to rotate. The device can generate ultrasonic waves in the radial direction, treatment of vaginitis is more facilitated, the ultrasonic waves can be radiated on the inner wall of the vagina in the circumferential direction by 360 degrees, and therefore the comprehensiveness of the radiation range is guaranteed.

Provided herein are methods of treating vaginitis by simultaneous local application per vagina of both boric acid and nitroimidazole. Also provided are compositions useful in such treatments, for instance containing 100-1,000 mg of nitroimidazole and 300-900 mg boric acid. Vaginal application of nitroimidazole allows a higher but safe dose to be administered simultaneously with boric acid for the effective treatment of bacterial vaginosis (BV). Also provided are methods for prophylactic treatment of patients, such as those prone to recurrent BV.

The invention provides temperature-sensitive poloxamer gel for preventing vaginal radiation injury and a preparation method of the temperature-sensitive poloxamer gel, and belongs to the technical field of medical gel. The temperature-sensitive type poloxamer gel is prepared from the following components: 6 percent to 18 percent of a poloxamer compound, 3 percent to 8 percent of a functional component, 0.01 percent to 0.08 percent of a penetration enhancer, 0.10 percent to 0.45 percent of a regulator, 0.13 percent to 0.25 percent of a humectant, 0.05 percent to 0.12 percent of a preservative and the balance of water, the poloxamer compound is prepared by compounding poloxamer 407 and poloxamer 188, and the poloxamer compound is prepared by compounding the poloxamer 407 and the poloxamer 188. The temperature-sensitive poloxamer gel for preventing the vaginal radiation injury, disclosed by the invention, is relatively long in retention time at an acting part, has a certain slow release effect, can keep long-time stimulation to vaginal mucosa, is beneficial to rapid healing of a wound surface, can effectively prevent radioactive vaginitis, is convenient to use, and is safe and non-irritant to a human body.

This invention provides a probiotic composition of Lab4 and Lactobacillus gasseri CUL09 and its application in reducing the risk of vaginal infections, belonging to the field of microbial application technology. Containing the Lab4 probiotic group and the novel strain Lactobacillus gasseri CUL09, this probiotic composition achieves vaginal flora reconstruction via oral administration, effectively improving vaginal pH, eliminating odor, and increasing lactobacillus colonization. This invention also relates to the combination of the probiotic composition with vitamin B6, cranberry extract, and conventional carriers, which can be used in the preparation of foods, dietary supplements, or pharmaceuticals for the prevention and / or treatment of vaginal and urethral microecological imbalances, vaginitis, vaginal candidiasis, and urethral infections. Furthermore, this invention, through the combination of Lab4 and Lactobacillus gasseri CUL09, achieves the inhibition of harmful vaginal bacteria, reconstruction of the vaginal flora to reduce the risk of vaginal infections, and can also prevent and treat urethral infections.

The invention relates to the technical field of biology, and discloses a Lactobacillus paracasei KFY202407 and an application thereof in preparation of a preparation for preventing and treating vaginitis, the collection number of the Lactobacillus paracasei KFY202407 in China General Microbiological Culture Collection Center (CGMCC) is CGMCC NO: 30736, and the collection date is May 22, 2024. The lactobacillus paracasei KFY202407 disclosed by the invention can relieve inflammation of mice with vaginitis by regulating secretion of mouse serum inflammatory factors, activity of vaginal tissue MPO and expression conditions of vaginal tissue inflammatory genes. The microbial inoculum prepared from the lactobacillus paracasei KFY202407 has good stability and can be used as a medicine raw material.