144 results about "Vaginitis" patented technology

The invention relates to lactobacillus gasseri FMTA1125B with the effect of preventing, relieving or treating vaginitis and application of the lactobacillus gasseri FMTA1125B. The lactobacillus gasseri FMTA1125B is classified and named as lactobacillus gasseri, and the preservation number of the lactobacillus gasseri FMTA1125B is CGMCC No.34292. The lactobacillus gasseri FMTA1125B has the effects of preventing, relieving or treating vaginitis and the application of the lactobacillus gasseri FMTA1125B. The bacterium can produce beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide through metabolism so as to regulate the genital tract environment and improve the health degree; and the traditional Chinese medicine composition has relatively good bacteriostasis and sterilization effects on common vaginal pathogenic bacteria such as escherichia coli, staphylococcus aureus, gardnerella vaginalis, candida albicans, neisseria gonorrhoeae and the like. Therefore, the lactobacillus gasseri FMTA1125B strain can be used for preparing a preparation with the effect of improving related genital tract diseases such as vaginitis.

The present invention relates to the screening of functional probiotics and its application, and specifically provides a strain of Lactobacillus casei RH99 that produces high extracellular polysaccharides and relieves vaginitis, and its preservation number is CGMCC No.32108. The Lactobacillus casei can inhibit the growth of Gardnerella, Candida albicans, and Peptostreptococcus and their biofilm generation ability; the extracellular polysaccharides produced by it have a significant promoting effect on the biofilm formation of Lactobacillus casei itself. RH99 is inoculated into the vagina, and its strain, the metabolites (exocellular polysaccharides) produced, and the core monosaccharide (D-mannitol) can all inhibit the colonization of pathogenic bacteria and promote the colonization of lactic acid bacteria; and RH99 can also relieve vaginitis by inhibiting inflammatory factors. It can be seen that RH99 can inhibit the growth of pathogenic bacteria + inhibit biofilm formation + inhibit pathogenic bacteria adhesion + inhibit the level of inflammatory factors through key core metabolites, and realize the all-round inhibition of four-in-one.

The present invention discloses a strain of Lactobacillus paracasei that simultaneously activates immune regulation and antioxidant pathways to alleviate vaginitis, belonging to the field of microbial technology. The present invention screened and obtained a strain of Lactobacillus paracasei CCFM1316, which has the effect of repairing related symptoms such as immune disorders and oxidative damage caused by vaginitis, specifically embodied in: reducing cellular NF-κB mRNA expression and cell supernatant IL-1β content, improving mouse vaginal immune response, enhancing mouse vaginal antioxidant capacity, improving mouse vaginal pathological manifestations and reducing pathogenic bacteria load. It reduces the mouse vaginal Gardnerella load and improves mouse vaginal pathological manifestations; therefore, Lactobacillus paracasei CCFM1316 has great application prospects in products that improve and repair immune disorders and oxidative damage problems caused by vaginitis.

The invention relates to lactobacillus gasseri FMTA1121E with an effect of regulating a vaginal micro-ecological environment and application of the lactobacillus gasseri FMTA1121E. The lactobacillus gasseri FMTA1121E is classified and named as lactobacillus gasseri, and the preservation number of the lactobacillus gasseri FMTA1121E is CGMCC No.34962. The lactobacillus gasseri FMTA1121E can be metabolized to generate beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide so as to regulate the genital tract environment and improve the health degree; and the bacillus subtilis has excellent bacteriostasis and sterilization effects on various common vaginal pathogenic bacteria such as escherichia coli, staphylococcus aureus, gardnerella vaginalis, candida albicans, neisseria gonorrhoeae and the like. Therefore, the lactobacillus gasseri FMTA1121E strain can be applied to preparation of preparations for preventing and treating related genital tract diseases such as vaginitis.

The invention relates to the technical field of biological medicine, in particular to # imgabs0 gynecological antibacterial gel for improving inflammatory response of vaginitis and vagina environment and application of the # imgabs0 gynecological antibacterial gel. The invention provides a postbiotic composition. The postbiotic composition comprises inactivated thalli of a probiotic composition and metabolites of the inactivated thalli; the probiotic composition is prepared from lactobacillus paracasei (Lactobacillus paracasei) ProSci-92 and lactobacillus rhamnosus ProSci-109, and the probiotic composition is prepared from lactobacillus paracasei (Lactobacillus paracasei) ProSci-92, lactobacillus rhamnosus (Lactobacillus rhamnosus) ProSci-109, lactobacillus rhamnosus (Lactobacillus rhamnosus) ProSci-109 and lactobacillus rhamnosus (Lactobacillus rhamnosus) ProSci-109. The preservation number of the lactobacillus paracasei ProSci-92 is CGMCC (China General Microbiological Culture Collection Center) No.26526; the preservation number of the lactobacillus rhamnosus ProSci-109 is CGMCC (China General Microbiological Culture Collection Center) No. 25449; the postbiotic composition can effectively slow down or treat inflammatory response of vaginitis and improve the vagina environment.

The invention discloses probiotics with an effect of improving vaginitis and a composite microecological preparation and application of the probiotics. The probiotics are characterized by comprising at least one of a plant lactobacillus 22-9 strain with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.33867, a plant lactobacillus XA-9 strain with the preservation number of CGMCC No.33868 and a plant lactobacillus pentosus B-1-35 strain with the preservation number of CGMCC No.33870, the preparation method comprises the following steps: inoculating a lactic acid bacteria starter, which is prepared by mixing lactic acid bacteria cultures of plant lactobacillus 22-9, plant lactobacillus XA-9 and plant lactobacillus pentosus B-1-35 according to a volume ratio of 2: 1: 3, into a fermentation culture medium according to a volume ratio of 1-5%, so as to prepare the probiotic compound microecological preparation. The number of inflammatory cells in the vagina is reduced, and the levels of inflammatory factors IL-1beta, IL-6 and TNF-alpha in serum are reduced.

The invention belongs to the technical field of female private part nursing, and particularly relates to andrographolide gel as well as a preparation method and application thereof. The invention provides an andrographolide gel, which is prepared from the following components in parts by mass: 0.1 to 0.5 part of andrographolide, 2.0 parts of caprylic / capric polyethylene glycol glyceride, 5.0 parts of propylene glycol, 0.05 to 0.2 part of chitosan, 10.0 parts of 1 percent W / V lactic acid solution, 0.15 to 0.6 part of hydroxyethyl cellulose and 30.0 parts of water. The andrographolide, the caprylic / capric polyethylene glycol glyceride, the propylene glycol, the chitosan, the 1% W / V lactic acid solution, the hydroxyethyl cellulose and the water are combined for use, the proportion of the components is strictly limited, and the obtained andrographolide gel can effectively inhibit vaginal pathogenic bacteria (including candida chromosomes, escherichia coli, staphylococcus aureus and gardnerella); the traditional Chinese medicine is used for treating fungal vaginitis and has no irritation to vaginal tissues.

The invention provides weak acid wet toilet paper special for women and a preparation process thereof, and belongs to the technical field of wet toilet paper preparation. The preparation process comprises the following steps: preparing the plant source weak acidity adjusting compound; preparing a bacteriostatic microcapsule compound; and preparing the weakly acidic wet toilet paper. The weakly acidic wet toilet paper prepared by the invention can relieve redness and pruritus of private skin caused by friction and secretion stimulation and enhance the skin barrier function, and an'instant bacteriostasis-long-acting regulation 'dual path is formed by the bacteriostatic component released by the microcapsule, the cranberry proanthocyanidin and the lactic acid bacteria metabolite, so that the recurrence rate of vaginitis is reduced.

The invention belongs to the technical field of preparation and application of probiotic postbiotics, and particularly relates to a composite probiotic postbiotic composition and application thereof. According to the compound probiotic metagen composition disclosed by the invention, the four probiotic metagens are compounded, so that vaginal harmful bacteria including bacteria and molds can be effectively inhibited, and the compound probiotic metagen composition has good in-vitro antibacterial activity; on the basis, the prebiotics are added into the composite probiotic postbiotic composition, so that the growth and stability of in-vivo lactobacillus inheritance can be promoted, the balance of vaginal flora can be recovered, and the diversity of species in microbial communities can be remarkably increased; meanwhile, symptoms such as vagina external redness and swelling, bleeding and pruritus caused by vaginitis can be effectively improved, no allergy phenomenon is generated, and therefore the compound can be applied to preparation of preparations for preventing and / or relieving vaginitis and can also be applied to production of antibacterial hygienic products, especially female hygienic products.

The invention discloses a lactobacillus acidophilus FMM01 with the effects of improving the contractility of pelvic floor muscles and repairing mucous membranes and application of the lactobacillus acidophilus FMM01, the lactobacillus acidophilus FMM01 is preserved in the China Center for Type Culture Collection, the preservation date is January 9, 2024, and the preservation number is CCTCC NO: M2024052. The lactobacillus acidophilus FMM01 has the advantages of self-adaption, high acid resistance, strong mucous membrane adhesiveness and no irritation to vaginal mucosa. The lyophilized powder is high in activity and excellent in stability; experimental results show that the lactobacillus acidophilus FMM01 can effectively inhibit bacteria, and especially can effectively inhibit enterobacter cloacae, vibrio parahaemolyticus and / or candida albicans. Besides, the lactobacillus acidophilus FMM01 can improve vaginal relaxation, improve pelvic floor muscle contractility and / or recover vaginal mucosa functions, can promote recovery of healthy florae after mixed vaginitis antibiotic / hormone treatment, improves the treatment effect of mixed vaginitis, and remarkably reduces the recurrence rate of mixed vaginitis.

The invention relates to the technical field of biology, in particular to leukocyte esterase detection test paper and a preparation method thereof. Based on the principle of a substrate and a color developing agent, the color developing depth is in direct proportion to the concentration of the esterase, so that the concentration of the leukocyte esterase in a detection sample can be judged according to the color developing depth; meanwhile, under the auxiliary action of calcium chloride and other materials, the detection distinction degree, the detection accuracy and the detection result stability are further improved. The leukocyte esterase test paper provided by the invention is simple in sample detection method, more stable in product performance, longer in validity period and wide in application range, can be used as an auxiliary evaluation index for vagina inflammation, and is combined with a cleanliness index and the like to jointly evaluate the vagina environment.

The invention provides a novel application of L-beta-galactoglucan, and particularly provides an application of the L-beta-galactoglucan in the aspect of resisting vaginitis.

The application discloses an active oxygen response type bacteriostatic and repair promoting hydrogel and a preparation method and application thereof, the hydrogel is formed by disulfide bond cross-linked hydrogel in response to active oxygen free radicals in the vagina of vaginitis patients through thiol modified hyaluronic acid (HASH), and can enhance in-vivo retention by thiol and vaginal tissue interaction. Cationic surfactant such as didecyldimethylammonium chloride (DDAC) as the bacteriostatic component of the hydrogel, efficiently killing pathogenic bacteria while having good biocompatibility, and is not prone to cause bacterial drug resistance. As a natural immune regulator, beta-glucan regulates the vaginal microenvironment, promotes the polarization of macrophages into anti-inflammatory M2 type and promotes cell migration, etc., to promote the repair of the vaginal immune barrier, regulate the vaginal flora, and reduce the probability of vaginitis recurrence. The HASH hydrogel provides an efficient, convenient and highly transformative potential strategy to provide more choices for the treatment of vaginitis.

The application belongs to the technical field of microorganisms, and particularly relates to two strains of lactobacillus plantarum PB12 and PB14 and application thereof in preventing or treating female vaginitis. lactiplantibacillus plantarum The application discloses two strains of lactobacillus plantarum (Lactobacillus plantarum), namely lactobacillus plantarum PB12 and lactobacillus plantarum PB14. The application also discloses application of the two strains of lactobacillus plantarum in preparing medicines or products for preventing and / or treating female vaginitis, including inhibiting growth of Candida albicans and relieving inflammation of a genital tract.

To provide compositions and methods for detecting bacterial nucleic acids and diagnosing bacterial vaginosis.SOLUTION: Disclosed is a method for diagnosing bacterial vaginosis in a subject comprising performing an assay to detect one or more of Lactobacillus spp., Atopobiumvaginae, and Gardnerallvaginalis in a sample of the subject. Also disclosed are compositions and methods for detecting Lactobacillus spp., Atopobiumvaginae, and / or Gardnerallvaginalis nucleic acids in a sample.SELECTED DRAWING: None

The invention relates to the field of prevention and treatment of vaginitis, in particular to a composition of lactobacillus rhamnosus LRa05, lactobacillus acidophilus La88 and lactobacillus plantarum Lp90 and application of the composition to regulation of vaginal mucosa barrier protein. The lactobacillus rhamnosus LRa05 is a lactobacillus rhamnosus LRa05 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) NO.24377, and the lactobacillus rhamnosus LRa05 is a lactobacillus rhamnosus LRa05 with the preservation number of CGMCC NO.24377. The lactobacillus acidophilus La88 is the lactobacillus acidophilus La88 of which the preservation number is CGMCC (China General Microbiological Culture Collection Center) NO.24109, and the lactobacillus acidophilus La88 is a lactobacillus acidophilus La88 of which the preservation number is CGMCC NO.24109. The lactobacillus plantarum Lp90 is the lactobacillus plantarum Lp90 with the preservation number of CGMCC (China General Microbiological Culture Collection Center) NO.10453, and the lactobacillus plantarum Lp90 has the preservation number of CGMCC NO.10453. The lactobacillus rhamnosus LRa05, the lactobacillus acidophilus La88, the lactobacillus plantarum Lp90 and the combination thereof disclosed by the invention can regulate the expression of the vagina mucosal barrier protein.

The invention relates to fermented lactobacillus mucus FMTA1124J with the function of improving the health degree of female genital tracts and application of the fermented lactobacillus mucus FMTA1124J. The classified name of the fermented lactobacillus mucus FMTA1124J is Limosilicilla fermentum, and the preservation number of the fermented lactobacillus mucus FMTA1124J is CGMCC No.34963. The fermented lactobacillus mucus FMTA1124J can produce beneficial components such as lactic acid, gamma-aminobutyric acid and hydrogen peroxide through metabolism so as to adjust the environment of the genital tracts and improve the health degree; and the traditional Chinese medicine composition has good bacteriostasis and sterilization effects on common vaginal pathogenic bacteria such as Escherichia coli, staphylococcus aureus, Gardneria vaginalis and Candida albicans. Therefore, the fermented lactobacillus mucus FMTA1124J strain can be used for preparing a preparation with the effect of improving related genital tract diseases such as vaginitis.

The invention relates to a metastatic composite fiber with a targeted antibacterial effect and a preparation method and application thereof.The metastatic composite fiber comprises a core layer, a skin layer and a metastatic microcapsule coating wrapping the skin layer, and the core layer is prepared from polyester and / or polypropylene; the preparation material of the skin layer comprises polyethylene and / or modified polyethylene, and the preparation raw materials of the metagen microcapsule coating comprise a metagen microcapsule and a hydrophilic oil agent. The prepared metastatic composite fiber has excellent mechanical properties and relatively high softness, also has an excellent effect of selectively inhibiting genital tract pathogenic bacteria, and can effectively improve the vagina environment of a user and relieve vagina inflammation when being applied to preparation of hygienic products; the micro-ecological balance of the vagina of the user is maintained; when applied to underwear and other close-fitting textile clothes, the fabric can effectively inhibit bacteria and maintain the stability of the micro-ecological environment of the skin surface layer.

The application discloses application of a traditional Chinese medicine composition in preparation of a medicine for treating vaginitis, and preparation raw materials of the traditional Chinese medicine composition include zedoary turmeric and Chinese atractylodes rhizome. The traditional Chinese medicine composition can kill common pathogenic bacteria of vaginosis, and has good bacteriostatic effect. While inhibiting the common pathogenic bacteria of vaginosis, the traditional Chinese medicine composition does not inhibit lactobacillus of vagina. The traditional Chinese medicine composition can not only kill single common pathogenic bacteria of vaginosis, but also relieve trichomonas vaginalis, and inhibit mixed infection of bacteria and fungi.

Disclosed herein are compositions and methods of manufacturing, testing, and using a biocompatible and disposable vaginal suppository, comprising chitosan, collagen, carboxymethyl cellulose, and an enzyme, capable of breaking down vaginal mucous and releasing the active ingredients consistently over extended periods of time. Methods disclosed herein may also include the use of these compositions, methods, and devices for treating vaginal diseases, such as vaginitis, genitourinary syndrome, and other conditions, such as vulvar and vaginal cancer, or cervical cancer.

The invention patent is titled "Dragon and Cypress Gel," belonging to the pharmaceutical category. The main components of Dragon and Cypress Gel are: Phellodendron bark, earthworm, dragon's blood, Oldenlandia diffusa, Sophora flavescens, and Bletilla striata. In recent years, research on cervicitis and cervical lesions has shown good results using external treatments of traditional Chinese medicine. Vaginal cervical medications are characterized by high local drug concentration, low dosage, and safety and effectiveness, receiving high clinical evaluation. The vagina and cervix have abundant capillaries and lymphatic vessels, and lack clearly defined nerve endings, resulting in minimal pain stimulation for patients during administration. This makes it an effective drug release site for specific diseases such as cervicitis and vaginitis. Traditional Chinese medicine gels are a novel type of external preparation of traditional Chinese medicine. They are made by dissolving or uniformly dispersing traditional Chinese medicine in a gel. These gels adhere tightly to the treatment site for a relatively long time, exhibiting good bioadhesion, and are simple to prepare. It is suitable for use on skin, mucous membranes and cavities. It not only avoids the first-pass effect of enzymes and acids in the gastrointestinal tract that exists in oral administration, but also reduces the adverse reactions of drugs. It has the characteristics of good spreadability, non-greasy feeling, easy to wash off, good transdermal absorption, and comfortable use.

The invention discloses a self-detection device for vaginitis, and belongs to the technical field of medical instruments, the self-detection device for vaginitis comprises a sampling cotton swab and a detection card, and further comprises a vaginal dilation assembly and a diluent containing assembly, the sampling cotton swab is movably inserted in the vaginal dilation assembly, the vaginal dilation assembly is detachably connected with the diluent containing assembly, and the detection card is connected with the sampling cotton swab. A connecting through hole corresponding to a cotton swab head of the sampling cotton swab is formed in the diluent containing assembly. The vagina expanding assembly can achieve the vagina expanding effect, and the cotton swab head can be cut off through contraction of the vagina expanding assembly after cotton swab sampling is completed, so that the cotton swab head can be rapidly soaked in a diluent, and a detection card can be conveniently used for detection. Besides, a sampling operation disc is arranged at the rear end of the cotton swab, a limiting assembly is arranged between the sampling operation disc and the vagina expanding assembly, the cotton swab can be fixed when the cotton swab is cut off, operation of a patient is facilitated, and it is guaranteed that the cotton swab can just fall into the diluent from a through hole in the diluent containing assembly.

The invention relates to the technical field of gynecological medical instruments, in particular to a medicine auxiliary device for treating vagina inflammation. The medicine taking auxiliary device for treating vagina inflammation comprises a box body, a controller, universal wheels, a handle, a medicine discharging mechanism and a medicine applying mechanism, the controller is installed at the top of the box body, the handle is connected to the top of the box body, the universal wheels are installed at the four corners of the bottom of the box body, and the medicine discharging mechanism and the medicine applying mechanism are arranged in the box body. Liquid medicine in the medicine cylinder is pumped out through the liquid pump, the liquid medicine flows through the medicine applying grab handle through a pipeline and then flows into the medicine applicator, then the first motor drives the transmission gear to rotate and the medicine applicator to rotate, and the liquid medicine flows out of the uniform medicine outlets in the medicine applicator and is uniformly applied to the vagina of a patient; the medicine liquid in the vagina of a patient is uniformly applied through the spiral convex lines on the applicator, so that the medicine liquid can play a better role, and the treatment effect is improved.

The application provides an LED optical therapeutic instrument for treating vaginitis, and relates to the technical field of optical therapeutic instruments, which comprises a moving cylinder, a battery box is fixed to the tail end of the moving cylinder, and the front end of the moving cylinder is provided with an opening, a pushing assembly is arranged in the moving cylinder, the pushing assembly comprises a front pipe, an intermediate pipe is arranged at the rear end of the front pipe, a rotating shaft is arranged between the front pipe and the intermediate pipe, a connecting layer is fixed to the tail end of the moving cylinder, a second screw rod is screw-connected in the connecting layer in a threaded manner, one end of the second screw rod is rotationally connected with the intermediate pipe through a bearing, and a mounting assembly is arranged at the bottom of the outlet end of the moving cylinder, through the unfolding of the inner supporting plate, the position of the disease is observed conveniently, the front pipe provided with a medicinal suppository is moved to the position through the pushing assembly, the medicinal suppository is applied to the position to be treated through the rotation of the rotating shaft, the position deviation is avoided, the sterilization and disinfection are concentrated through the irradiation of the irradiation lamp, and the treatment effect is improved.

The present invention provides the use of L-theanine in preparing a preparation for treating vaginitis. The L-theanine of the present invention can significantly reduce vaginal pH, improve tissue pathology scores, and is significantly effective for vaginitis.

The utility model discloses a kind of medicine applying devices for gynaecology vaginitis, belong to gynaecology medical instrument technical field, a kind of medicine applying device for gynaecology vaginitis, including push plate, push plate front end is fixedly connected with medicine applying structure, medicine applying structure inside is threadedly connected with injection structure, push plate rear end is fixedly connected with limit ring, push plate inner surface and limit ring inner surface are threadedly connected with push structure, it is cooperated by medicine applying structure and push structure, when gynaecology doctor treats vaginitis patient, capsule, tablet and powder drug can be quickly sent into patient vagina, complete medicine applying, by injection structure and medicine applying structure and push structure cooperation, so that device can also complete liquid medicine applying, eliminate limitation, by push structure, so that the controllability of device is higher, can effectively avoid to cause harm to the inside of patient's vagina, can realize the function of convenient liquid medicine and high operating precision, improve the practicality of device.

The invention discloses skin mucosa maintenance liquid capable of killing fungi and HPV (human papillomavirus) as well as a preparation method and application of the skin mucosa maintenance liquid, and belongs to the technical field of sterilization and virus removal. The skin mucosa maintenance liquid is prepared from octanol ether, benzalkonium bromide, phenoxyethanol, yermate, parachlorometaxylenol, taetinic acid, chitosan, keratinase, fluconazole, glycerol, borneol, menthol, absolute ethyl alcohol and tween-40. Wherein the skin mucosa maintenance liquid has an effect of regulating apoptosis induction on abnormal cells and an effect on vaginal flora, and has an obvious inhibition effect on cervicitis and colpitis mycotica, namely an anti-inflammatory effect; meanwhile, apoptosis of cells containing HPV16 and HPV18 genes can be induced, shedding of abnormal cells is promoted, diseased cells are killed, and vaginal tissues with pathological changes are removed.

The application relates to an intelligent diagnosis method for cervical cell atrophy levels, and relates to the problem that intelligent discrimination of cervical cell atrophy degrees is lacking in automatic pathological diagnosis technology. Cervical vaginal squamous epithelium is divided into surface layer cells, middle layer cells and basal layer cells, and ovarian estrogen affects the growth and maturity of the cells; a decrease in estrogen level can cause symptoms such as atrophic vaginitis and osteoporosis, which need to be treated in time; at present, squamous cell atrophy diagnosis is not clear enough, and there are few reports on atrophy degree diagnosis research, so it is of great significance to establish a systematic and intelligent diagnosis process for cervical cell atrophy degree discrimination. In order to improve the problem, the application provides an intelligent diagnosis method for cervical cell atrophy levels; the method first detects the surface layer cells, the middle layer cells and the basal layer cells by using a target detection model, then segments the cell nucleus of each layer of cells detected by using an instance segmentation model, and finally calculates the cell quantity ratio, the nucleus-cytoplasm ratio and the cell crowding degree index of each layer; the indexes are input into a random forest classification model to grade the atrophy degree; it is known through sufficient experimental verification that good effects are achieved in cervical cell atrophy degree discrimination. The application is applied to cervical cell atrophy degree discrimination.

The invention relates to the technical field of probiotic application, in particular to application of lactobacillus crispatus HC1261 in preparation of a microbial agent for improving female reproductive health and a composition for improving vagina inflammation. The lactobacillus crispatus HC1261 is preserved in the China General Microbiological Culture Collection Center (CGMCC) on May 16, 2023, the preservation address is No.3, No.1 yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No.27355; the microbial inoculum for improving female reproductive health can reduce the load of the ureaplasma urealyticum in the vagina. The lactobacillus crispatus HC1261 can be used for pertinently reducing the load of the ureaplasma urealyticum in the vagina, and can be used for reducing the related health risks of urethritis, cervicitis, pelvic inflammation, infertility and the like caused by the ureaplasma urealyticum.

The invention discloses an injectable photo-crosslinking hydrogel loaded with pseudolaric acid as well as a preparation method and application thereof. The preparation method comprises the following steps: 1) respectively dissolving Gelma and HAMA in sterile PBS (Phosphate Buffer Solution) according to the dosage required by a final system; 2) mixing the two solutions, and adding a photoinitiator LAP pre-dissolved in the sterile PBS at 60 DEG C; 3) dissolving golden larch bark acetic acid in dimethyl sulfoxide to prepare a medicine solution with the concentration of 1.0 mg / mL, and then adding the medicine solution into the precursor solution under the condition of continuous stirring; and 4) carrying out 405 nm illumination crosslinking on the obtained precursor solution to form the hydrogel. The hydrogel three-dimensional network can continuously and controllably release pseudolaric acid, maintains a long-acting effective drug concentration at an infected part, shows a strong inhibition effect on a candida albicans standard strain and a clinical drug-resistant strain, and has a good application prospect in a model for treating candida vaginitis and fungal skin wound infection. And all the components show a remarkable'anti-infection-repair promoting 'integrated treatment effect.