19 results about "Vaginitis" patented technology

The application discloses an active oxygen response type bacteriostatic and repair promoting hydrogel and a preparation method and application thereof, the hydrogel is formed by disulfide bond cross-linked hydrogel in response to active oxygen free radicals in the vagina of vaginitis patients through thiol modified hyaluronic acid (HASH), and can enhance in-vivo retention by thiol and vaginal tissue interaction. Cationic surfactant such as didecyldimethylammonium chloride (DDAC) as the bacteriostatic component of the hydrogel, efficiently killing pathogenic bacteria while having good biocompatibility, and is not prone to cause bacterial drug resistance. As a natural immune regulator, beta-glucan regulates the vaginal microenvironment, promotes the polarization of macrophages into anti-inflammatory M2 type and promotes cell migration, etc., to promote the repair of the vaginal immune barrier, regulate the vaginal flora, and reduce the probability of vaginitis recurrence. The HASH hydrogel provides an efficient, convenient and highly transformative potential strategy to provide more choices for the treatment of vaginitis.

The application belongs to the technical field of microorganisms, and particularly relates to two strains of lactobacillus plantarum PB12 and PB14 and application thereof in preventing or treating female vaginitis. lactiplantibacillus plantarum The application discloses two strains of lactobacillus plantarum (Lactobacillus plantarum), namely lactobacillus plantarum PB12 and lactobacillus plantarum PB14. The application also discloses application of the two strains of lactobacillus plantarum in preparing medicines or products for preventing and / or treating female vaginitis, including inhibiting growth of Candida albicans and relieving inflammation of a genital tract.

The application discloses application of a traditional Chinese medicine composition in preparation of a medicine for treating vaginitis, and preparation raw materials of the traditional Chinese medicine composition include zedoary turmeric and Chinese atractylodes rhizome. The traditional Chinese medicine composition can kill common pathogenic bacteria of vaginosis, and has good bacteriostatic effect. While inhibiting the common pathogenic bacteria of vaginosis, the traditional Chinese medicine composition does not inhibit lactobacillus of vagina. The traditional Chinese medicine composition can not only kill single common pathogenic bacteria of vaginosis, but also relieve trichomonas vaginalis, and inhibit mixed infection of bacteria and fungi.

Disclosed herein are compositions and methods of manufacturing, testing, and using a biocompatible and disposable vaginal suppository, comprising chitosan, collagen, carboxymethyl cellulose, and an enzyme, capable of breaking down vaginal mucous and releasing the active ingredients consistently over extended periods of time. Methods disclosed herein may also include the use of these compositions, methods, and devices for treating vaginal diseases, such as vaginitis, genitourinary syndrome, and other conditions, such as vulvar and vaginal cancer, or cervical cancer.

The invention patent is titled "Dragon and Cypress Gel," belonging to the pharmaceutical category. The main components of Dragon and Cypress Gel are: Phellodendron bark, earthworm, dragon's blood, Oldenlandia diffusa, Sophora flavescens, and Bletilla striata. In recent years, research on cervicitis and cervical lesions has shown good results using external treatments of traditional Chinese medicine. Vaginal cervical medications are characterized by high local drug concentration, low dosage, and safety and effectiveness, receiving high clinical evaluation. The vagina and cervix have abundant capillaries and lymphatic vessels, and lack clearly defined nerve endings, resulting in minimal pain stimulation for patients during administration. This makes it an effective drug release site for specific diseases such as cervicitis and vaginitis. Traditional Chinese medicine gels are a novel type of external preparation of traditional Chinese medicine. They are made by dissolving or uniformly dispersing traditional Chinese medicine in a gel. These gels adhere tightly to the treatment site for a relatively long time, exhibiting good bioadhesion, and are simple to prepare. It is suitable for use on skin, mucous membranes and cavities. It not only avoids the first-pass effect of enzymes and acids in the gastrointestinal tract that exists in oral administration, but also reduces the adverse reactions of drugs. It has the characteristics of good spreadability, non-greasy feeling, easy to wash off, good transdermal absorption, and comfortable use.

The utility model discloses a kind of medicine applying devices for gynaecology vaginitis, belong to gynaecology medical instrument technical field, a kind of medicine applying device for gynaecology vaginitis, including push plate, push plate front end is fixedly connected with medicine applying structure, medicine applying structure inside is threadedly connected with injection structure, push plate rear end is fixedly connected with limit ring, push plate inner surface and limit ring inner surface are threadedly connected with push structure, it is cooperated by medicine applying structure and push structure, when gynaecology doctor treats vaginitis patient, capsule, tablet and powder drug can be quickly sent into patient vagina, complete medicine applying, by injection structure and medicine applying structure and push structure cooperation, so that device can also complete liquid medicine applying, eliminate limitation, by push structure, so that the controllability of device is higher, can effectively avoid to cause harm to the inside of patient's vagina, can realize the function of convenient liquid medicine and high operating precision, improve the practicality of device.

This invention relates to the field of gene detection technology, specifically to a primer set and its application, and a training method for a bacterial vaginosis diagnostic model. The primer set, used for diagnosing bacterial vaginosis, includes specific primers for specifically amplifying target regions of the following pathogens: *Atopobacterium vaginalis*, *Gardnerella vaginalis*, *Cyclophorus 1*, *Cyclophorus 2*, *Bacterial Vaginosis-Associated Bacteria 2*, *Animal Curvularia clarithii*, *Animal Curvularia emblica*, *Prevotella 2*, *Lactobacillus curvularia*, *Lactobacillus indolentus*, *Lactobacillus gasseri*, and *Lactobacillus janniae*. This invention also provides the application of this primer set and a training method for a bacterial vaginosis diagnostic model. Using this primer set, high-throughput sequencing can be performed on test samples, simultaneously detecting 12 target pathogens, and further constructing a bacterial vaginosis diagnostic model, which can be used for the clinical diagnosis of bacterial vaginosis with good specificity and sensitivity.

This invention provides a probiotic composition of Lab4 and Lactobacillus gasseri CUL09 and its application in reducing the risk of vaginal infections, belonging to the field of microbial application technology. Containing the Lab4 probiotic group and the novel strain Lactobacillus gasseri CUL09, this probiotic composition achieves vaginal flora reconstruction via oral administration, effectively improving vaginal pH, eliminating odor, and increasing lactobacillus colonization. This invention also relates to the combination of the probiotic composition with vitamin B6, cranberry extract, and conventional carriers, which can be used in the preparation of foods, dietary supplements, or pharmaceuticals for the prevention and / or treatment of vaginal and urethral microecological imbalances, vaginitis, vaginal candidiasis, and urethral infections. Furthermore, this invention, through the combination of Lab4 and Lactobacillus gasseri CUL09, achieves the inhibition of harmful vaginal bacteria, reconstruction of the vaginal flora to reduce the risk of vaginal infections, and can also prevent and treat urethral infections.

This invention belongs to the field of microbial technology, specifically relating to the multifunctional Lactobacillus curvatureii and its application in the preparation of health products. The Lactobacillus curvatureii (… Lactobacillus crispatus Lactobacillus crispatus The accession number for MCOlact00102 is CGMCC No. 34381. The described *Lactobacillus curvatureensis* (MCOlact00102) is... Lactobacillus crispatus ​ The two strains, MCOlact00126 (CGMCC No. 34382), exhibit significant inhibitory effects against bacterial vaginosis (BV) and infections caused by Gardnerella vaginalis, Group B Streptococcus (GBS), Escherichia coli, or Candida albicans. The safety of these strains was evaluated using a 3D vaginal epithelial organoid model, showing no irritant effect on cells. Furthermore, hemolytic activity tests, antibiotic resistance gene detection, and functional validation all demonstrated their good safety profile. In addition, the aerobic acclimation process significantly improved the stability and bioactivity of these two strains in actual production and clinical applications, laying a solid foundation for their industrialization and application.

The application discloses a composition for relieving vaginitis by simultaneously activating immune regulation and antioxidant pathways, and belongs to the technical field of microorganisms. The application screens a composite strain containing a strain of Paracaseolovis casei CCFM1316 and a strain of Paracaseolovis casei CCFM1317, and the composition containing the composite strain has the effect of repairing immune disorders, oxidative damage and other related symptoms caused by vaginitis, which is specifically embodied in: regulating the immune response of the mouse vagina; activating the TLR-4 / MyD88 pathway, and reducing the IL-1beta concentration of the vaginal tissue to 29.79 ng / L; improving the oxidative stress of the mouse vagina; and increasing the Nrf2 of the vaginal tissue to 36.58 ng / L. Therefore, the composition of the Paracaseolovis casei CCFM1316 and the Paracaseolovis casei CCFM1317 has great application prospect in products for improving and repairing the inflammatory response and oxidative damage caused by vaginitis.

The application discloses a kind of based on attention mechanism and multi-scale fusion's vaginitis pathogen cell detection method and system.The method will be obtained in advance vaginal secretion immunofluorescence microscopic image input training completed optimal pathogen detection model, output the detection result of recognition trichomonad, leukocyte, epithelial cell, clue cell and spore.The application is based on deep learning algorithm to realize the automatic high-efficiency accurate detection of vaginitis pathogen cell, improve the confirmed diagnosis rate of vaginitis, greatly reduce the probability of missed detection, misdiagnosis phenomenon in diagnosis process.According to pathogen cell detection result, simulate clinical diagnosis output, realize pathogen cell classification judgment, provide reliable basis for the automation auxiliary diagnosis of vaginitis.

The present application relates to the technical field of microorganisms, and particularly relates to a saliva host-associated lactobacillus V118 and application thereof. The saliva host-associated lactobacillus V118 has good inhibiting capacity on Candida albicans and mold, has strong adhesion capacity, has good anti-inflammatory effect, can effectively improve female vaginitis, has good safety, and has good application prospect. The strain can be used as a new type of probiotic resource, used for developing female vaginal health products, filling the market gap, and promoting the scientific development of female microecological health products.

The present invention relates to a vaginal cleaning composition comprising a bacteriostatic complex and a lactic acid bacteria ferment obtained by co-fermentation of a plurality of lactic acid bacteria strains in appropriate proportions, wherein the bacteriostatic complex can effectively inhibit vaginal inflammation pathogens, and the lactic acid bacteria ferment can promote the growth of probiotics in the vagina. Therefore, the above-mentioned vaginal cleaning composition can effectively inhibit vaginal inflammation pathogens, while avoiding the change of the acidic environment of the vagina caused by the inhibition of probiotics in the vagina by the bacteriostatic complex. A cleaning method for the vagina using the above-mentioned vaginal cleaning composition is also disclosed.

The application discloses a lactobacillus rhamnosus capable of improving oxidative damage to relieve vaginitis, and belongs to the technical field of microorganisms. The lactobacillus rhamnosus has the effect of repairing oxidative damage related symptoms caused by vaginitis, and further improves intestinal health problems caused by vaginitis, specifically embodied in: reducing cell Keap1 mRNA expression, increasing cell supernatant Nrf2 content; improving mouse vaginal oxidative stress: activating the Keap1 / Nrf2 pathway, increasing the Nrf2 level of vaginal tissue; enhancing the antioxidant capacity of the mouse intestinal tract: reducing the Keap1 mRNA level of colon tissue; improving the pathological characteristics of the mouse vagina and reducing the pathogenic bacterial load. Therefore, the lactobacillus rhamnosus CCFM1315 has great application prospect in products for improving and repairing the vaginal oxidative damage problems caused by vaginitis.

The utility model discloses a visual female rabbit artificial insemination insemination gun belongs to female rabbit insemination field. A visual female rabbit artificial insemination insemination gun, include: handle, still include: probe pipe, fixed setting in the upper side of handle, baffle ring, set up in the end of probe pipe, probe head, set up in the probe pipe, and the probe head is close to the upper side of probe pipe inner wall, micropump machine, set up in the handle, draw liquid pipe, set up between the draw liquid end of baffle ring and micropump machine, storage bottle, set up in the lower side of handle, liquid discharge pipe, set up between the liquid discharge end of storage bottle and micropump machine, button, set up in the handle, the utility model effectively carries out the cleaning to mucus, and female rabbit is more easily accepted to relative to the mode of air blowing, and convenient operation personnel real -time observation insemination position, facilitate observation endometrium state, exclude female rabbit who suffers from endometritis or vaginitis, improve female rabbit conception rate.

The application discloses probiotics for improving bacterial vaginosis and a composition and application thereof, characterized in that the probiotics are at least one of a fermented Mucilaginis lactobacillus QS150 strain with a preservation number of CGMCC No. 34373, a curled lactobacillus QS204 strain with a preservation number of CGMCC No. 34371 and a Roy's Mucilaginis lactobacillus QS020 strain with a preservation number of CGMCC No. 34372, and the composition is a mixture of the three strains in a proportion of 1:1:1 in terms of viable bacterial quantity, and has an application in preparing products for preventing, relieving or treating bacterial vaginosis, and has the advantages of having antioxidant properties, producing acid and hydrogen peroxide, and inhibiting female vaginal pathogenic bacteria, and improving bacterial vaginosis.

This invention relates to the field of traditional Chinese medicine composition technology, and particularly to a traditional Chinese medicine composition for treating damp-heat type vaginitis or damp-heat type HPV and its preparation method. The traditional Chinese medicine composition for treating damp-heat type vaginitis or damp-heat type HPV of this invention has the advantages of rapid efficacy and few side effects. The principal herbs are Gentiana scabra, Artemisia capillaris, and Prunella vulgaris, which are cold in nature and clear excess heat in the liver and gallbladder, and clear damp-heat in the lower burner; the assistant herb is Scutellaria baicalensis, which is bitter and cold and clears heat, assisting Gentiana scabra and Prunella vulgaris in clearing heat and detoxifying; the adjuvant herbs are Rehmannia glutinosa, Hedyotis diffusa, and Forsythia suspensa, which have the effects of clearing heat and detoxifying; the guiding herbs are Plantago asiatica and Salvia miltiorrhiza. Plantago asiatica promotes diuresis and eliminates dampness, guides heat downwards, and allows damp-heat to be expelled through urination; Salvia miltiorrhiza, the guiding herb, enters the heart and liver meridians, is bitter and slightly cold in taste, and has blood-activating effects. Modern medical research shows that it has the effect of inhibiting the release of inflammatory factors and reducing tissue inflammatory reactions. This invention, through the combination of its components, achieves significant therapeutic effects on damp-heat type vaginitis and damp-heat type HPV.

This invention discloses a strain of *Lactobacillus johnsonii* and its metabiotic that simultaneously improves vaginal mucosal damage and inhibits vaginal inflammation, belonging to the field of microbial technology. The *Lactobacillus johnsonii* strain of this invention was isolated from vaginal secretions of healthy women. It has the effects of improving vaginal mucosal damage and inhibiting vaginal inflammation, specifically manifested in: promoting the migration and repair of vaginal epithelial cells; reducing the content of soluble cadherin E in the vaginal mucosa of mice and increasing the expression of vaginal tight junction protein OCLN; reducing the shedding of vaginal mucosal epithelial cells; reducing the secretion of MPO and IL-1β in mice with vaginitis; and (6) improving the pathological characteristics of the vagina in mice. Therefore, this *Lactobacillus johnsonii* has great application potential in products that improve vaginal mucosal damage and inhibit vaginal inflammation.

This invention belongs to the field of biomedical technology, and relates to an in-situ foam gel containing exosomes, its preparation method, and its application. The raw materials for preparing the in-situ foam gel include an oil phase, a surfactant, surfactant auxiliaries, a gel matrix, a bioactive agent, exosomes, and a solvent. The surfactant includes any one or a combination of at least two of Tween 80, vitamin E polyethylene glycol succinate, or lecithin. The in-situ foam gel containing exosomes of this invention can form porous foam in situ within the uterine cavity, cervix, and vagina, and is used to prevent postoperative intrauterine adhesions, promote endometrial regeneration, and treat bacterial and mixed vaginitis, especially suitable for repair treatment after hysteroscopic surgery or curettage.