52 results about "Nootkatone" patented technology

Extracts of vetiver oil were found to significantly repel termites. In one extract, nootkatone was isolated and found to be a significant repellent and toxicant of termites. Nootkatone significantly decreased food consumption, decreased tunneling behavior, and increased mortality in termites. Nootkatone is an effective repellent and toxicant of termites either by itself or as an addition to other materials or substrates, including mulches made from vetiver grass roots or other wood products. Nootkatone can also be used to protect construction wood from attack by Formosan subterranean termites. Nootkatone as a repellent is non-toxic to humans and other mammals and is environmentally safe. In addition, α-cedrene was found to be a weak termite repellent; and both zizanol and bicyclovetivenol were found to be repellents and toxicants of termites.

A method for extracting and purifying natural perfume that is valencene and nootkatone in the walnut extracts and purifies valencene and nootkatone by the processes of supercritical fluid extraction, dissolvant liquid-liquid extraction, high precision fractionation, preparing chromatography, and recrystallization in turns, comprising: extracting the walnut by fluid under a supercritical state, performing a liquid-liquid extraction using lower alcohol solution through an emulsification pump and a homogenizer, mixing the walnut oil and alcohol solution, emulsifying the solution to achieve a full liquid-liquid contact and extraction, the high precision fractionation using vacuum fractionation, fractionating hydrocarbons component of the walnut oil after liquid-liquid extraction to obtain valencene, using polyporous material as a chromatography fillers, chromatographically separating and recrystallizing a crude product of nootkatone obtained form alcohol solution after liquid-liquid extraction to obtain the purified nootkatone.

The invention discloses a quality detection method for Liangfu (of which the main compositions are rhizoma alpiniae officinarum and rhizoma cyperi) pill-like preparations. The method is a thin-layer chromatography method, and detection is performed by taking alpha-cyperone, cyperotundone, nootkatone, galangin and kaempferol as index components. The expansion conditions of the thin-layer chromatography comprise petroleum ether and ethyl acetate with the volume ratio of 5:1, and the thin-layer plate is silica gel GF254 plate. The quality detection method is capable of simultaneously detecting five index components in the Liangfu pill-like preparations, the environment adaptability is high, the method is simple, separation of the index components is good, and effective guarantee is provided for comprehensive detection on the quality of the Liangfu pill-like preparations.

The invention discloses a sharpleaf galangal fruit extract capable of treating chronic kidney diseases. The extract is prepared by the following steps: grinding sharpleaf galangal fruits to remove the shells, adding a certain amount of ethanol, carrying out reflux extraction, collecting the extract, making the extract go through macroporous resin, eluting the macroporous resin by low-concentration ethanol to remove the impurities, then eluting the macroporous resin by high-concentration ethanol, condensing to obtain extract, separating the extract in a silica gel column, and carrying out crystallization so as to obtain the sharpleaf galangal fruit extract. According to the pathogenesis of chronic kidney diseases and on the basis of traditional Chinese medicine theory, the inventor researches the chemical components and the clinical curative effect of sharpleaf galangal fruit. The results of a great number of experiments show that the prepared sharpleaf galangal fruit extract (nootkatone) can prominently reduce proteinuria, can also obviously reduce the levels of serum creatinine and urea nitrogen, has a good kidney protective effect, and can be used to prevent and treat chronic kidney diseases.

A process for preparing the nootkatone used for essence of cigarette includes such steps as extracting valencene from valerian oil by supercritical separation, and converting it to nootkatone in the solution of sodium hypochlorite-tert-butyl hydrogen peroxide (TBHP) mixture.

An inexpensive, stereoselective synthesis for nootkatone, tetrahydronootkatone, and their derivatives is disclosed. The starting materials used in the synthesis are inexpensive. The principal starting material, (-)-beta-Pinene, is on the GRAS list (generally recognized as safe).

The invention discloses a technology for extracting nootkatone from shaddock peel. Simultaneous distillation-extraction and molecular imprinting template extraction are organically combined, nootkatone volatile oil is extracted from the shaddock peel through the simultaneous distillation-extraction, the volatile oil is extracted and separated by an extracting agent containing a molecular imprinting template, high-purity nootkatone is obtained, and the technology is simple and convenient to operate, has low requirement for equipment and facilitates industrial production; in the step of extracting and separating the volatile oil by the extracting agent containing the molecular imprinting template, types and dosages of solvents, functional monomers, cross-linking agents and initiators are selected, so that polymerization conditions are optimized, molecularly imprinted polymers with better particle size distribution and physical stability and good adsorptive property are prepared, nootkatone can be recognized selectively, adsorption extent of nootkatone is high, and the technology has good extraction performance.

Compositions and methods for treating and preventing mosquito infestations are disclosed herein. Also disclosed herein are compositions and methods to reduce or prevent the spread of diseases for which mosquitoes may act as a vector.

The invention discloses a series of novel nookatone thioether derivatives each containing a 1,3,4-oxadiazole ring, and a preparation method and application of the novel nookatone thioether derivatives. According to the series of compounds, nootkatone serves as a raw material, chlorine atoms are introduced to the allyl position of nootkatone to synthesize 13-chloro nootkatone, the 13-chloro nootkatone and 5-aryl-2-sulfydryl-1,3,4-oxadiazole are subjected to a substitution reaction to generate a series of novel nootkatone derivatives, and the structural general formula of the nootkatone derivatives is shown in the formula (I). According to the nootkatone thioether derivatives, the 1,3,4-oxadiazole group has various biological activities, especially in the aspect of insecticidal activity, after the nootkatone thioether derivative is combined with nootkatone, the derivative has good insecticidal activity, and the nootkatone thioether derivative is expected to be used for preparing a novel natural product insecticide; and the compound is simple in preparation process, low in cost and relatively non-toxic to non-standard target biological fish and shrimp seeds. In the formula, R is selected from non-substituted or substituted phenyl or pyridyl, and the substituted phenyl is phenyl substituted by halogen, C1-C4 alkyl, C1-C4 alkoxy, nitro or cyano.

The invention discloses a method for identifying Fujian Guanxi honey pomelos by a chromatography method. According to the method, firstly, acetonitrile is used for extracting chemical ingredients in each position of outer peels, endodermis, endocarp, pulp and the like of the honey pomelos; then, a gas chromatograph, a hydrogen flame ionization detector and a liquid chromatogram-ultraviolet detector is used at the same time for detection; chemical ingredients in each position of the Fujian Guanxi honey pomelos are subjected to chromatographic qualitative analysis; specific substances of cnidium lactone, limonene, alpha-linoleic acid, palmitic acid, sitosterol, oleamide and nootkatone and the like in the Fujian Guanxi honey pomelos can be accurately detected; a honey pomelo specific substance chromatographic fingerprint chromatogram is successfully built. The method provided by the invention has the advantages that the operation is simple; the qualitative detection is accurate; the detection is fast; the method belongs to a fire-new fast, accurate and simple honey pomelo origin traceability and quality identification method.

This disclosure relates to a method for the control or repellency of biting arthropods. The method comprises bringing the biting arthropods into contact with a biting arthropod repellent formulation. The biting arthropod repellent formulation comprises nootkatone in combination, or in synergistic combination, with skin or plant derived compounds and compounds structurally similar to them (e.g., ketones, cyclic ketones, esters, gamma or delta lactones, and branched and/or unsaturated carboxylic acids), and/or one or more repellents selected from the group consisting of DEET®, para-menthane-3,8-diol (PMD), Picaridin, ethyl 3-[acetyl(butyl)amino]propanoate (IR3535), and other nitrogen-containing repellents including amines, amides, and nitrogen-containing heterocyclic compounds. This disclosure also relates to a biting arthropod repellent formulation comprising nootkatone in combination, or in synergistic combination, with the skin or plant derived compounds and compounds structurally similar to them, and/or the one or more repellents.

The invention relates to methods for producing glycosylated nootkatol. In particular, a recombinant host comprising a gene encoding a UDP-glycosyltransferase polypeptide capable of glycosylating nootkatol is disclosed. Glycosylation of nootkatol detoxifies nootkatol, allowing for greater production of (glycosylated-)nootkatol, a precursor of nootkatone, and therefore greater production of nootkatone. The invention also relates to methods of converting non-toxic, glycosylated nootkatol produced by a recombinant host to nootkatol, wherein the nootkatol can subsequently be converted to large quantities of nootkatone to be used in flavorings, perfumes, and/or insect repellents.

The invention relates to the field of microorganisms, in particular to a Burkholderia and application thereof. A method for preparing the Burkholderia comprises the following steps: firstly, performing preliminary screening, diluting a sample bacterial suspension, coating a flat plate with the diluted sample bacterial suspension, picking a single colony, taking valencene as a unique carbon source,drawing a growth curve for preliminary screening, and selecting a well-growing strain for a next experiment; secondly, performing secondary screening, analyzing and comparing the yield of nootkatonewhich is generated by biological conversion of the valencene through the strain, and selecting a strain with high yield of the nootkatone for a next experiment; and performing streaking on the selected strain, and analyzing and determining a product obtained by the biological conversion of the valencene through the strain and the content of the product. Compared with the conventional physical andchemical synthesis methods, the method for preparing the Burkholderia has the characteristics of high specificity, mild reaction conditions, high reaction rate, high yield, low cost, few reaction steps and the like; moreover, the nootkatone produced in such a way belongs to a natural spice and can be added into foods, cosmetics and other household products.