183 results about "BACTERIAL INFECTIOUS DISEASES" patented technology

This invention provides compounds of formula (I) or its pharmacologically acceptable salt or solvate, wherein A represents aryl or a monocyclic or bicyclic heterocyclic group, R₁ represents a halide, nitro, substituted C_1-6 alkyl, optionally substituted amino, C_1-6 alkyloxycarbonyl, optionally substituted aryl, a heterocyclic group, or heterocyclic carbonyl, R₂ represents a hydrogen atom or C_1-6 alkyl, R₃ represents C_1-6 alkyl, all of R₄, R₅, and R₆ represent a hydrogen atom, R₇ represents C_1-6 alkyl, m is 1 or 2, and n is 1. The compounds are novel lincomycin derivatives having a potent activity against resistant pneumococci. The compounds can be used as an antimicrobial agent and are useful for preventing or treating bacterial infectious diseases.

The present invention discloses the new use of available antimalarial arteannuin and its derivatives dihydro arteannuin, antiannuic methyl ether, antiannuic ethyl ether and antiannuic amber. Arteannuin and its derivatives are used through combination with antibiotic medicine to inhibit bacterial growth and enhance the antibiotic effect of available antibiotic medicine. Especially, antiannuic amber is applied in preventing and treating bacterial infection diseases except being used as antimalarial.

The present invention relates to a lipid nanomaterial containing lysophosphatidylcholine or an ether derivative thereof, a method for preparing the same, a method for reducing erythrocyteolysis and hemagglutination using the compound, and a pharmaceutical agent containing the lipid nanomaterial. The present invention contains lysophosphatidylcholine or an ether derivative thereof as an active ingredient, and can be useful as a treatment agent for septicemia, bacterial infection diseases, and the like.

The invention relates a cyanopyridyl-replaced oxazolidinone compound with a general formula (I); wherein, R1 is hydrogen, fluorine, chlorine or trifluoromethyl and R is shown in the right structural formula. The invention also provides a preparation method of the compound shown in general formula (I) and medicinal salts of the compound and an application thereof for curing microbial infections, in particular to bacterial infection diseases. Preliminary antibacterial activity tests in vitro show that the compound of the invention has better antibacterial activity compared with linezolid and obvious antibacterial activity to drug-resistant bacteria.

The invention belongs to the field of medicines and particularly relates to a new application of an iridoid glycoside compound, genipin-1-[beta]-D-gentiobioside, and a composition composed by compounding the genipin-1-[beta]-Dgentiobioside with other components as effective components for preparing antiviral drugs, antibacterial drugs, fever alleviating drugs, inflammation resistant drugs and anti-oxidizing drugs. The iridoid glycoside compound and the composition can be used for treating acute respiratory infection, flu, pneumonia, viral hepatitis type B, herpes zoster, herpes viral keratitis, viral myocarditis, Epstein-Barr virus infection, retrovirus infectious diseases and bacterial infectious diseases.

The invention provides application of patchouli oil to preparing drugs for treating bacterial infectious diseases. The invention also provides a drug composition for treating the bacterial infectious diseases. The drug of the invention has stronger internal and external antibacterial activity on resistant strains in gram positive bacteria and gram negative bacteria and escherichia coli, can effectively treat infectious diseases caused by the resistant strains in clinical gram positive bacteria and gram negative bacteria as well as the resistant strains and sensitive strains in the escherichia coli, and provides a new drug selection for clinic.

The invention discloses an oil emulsion containing banksia rose oil and its preparing process, wherein the emulsion comprises rich costunolide and dehydrogenated costuslactone. The invention also provides its use in preparing medicament for the treatment of endotoxemia caused by various reasons.

The present invention discloses a combination of Chinese medicines for poultry and the preparation method and application. Hypericum forsythia and bidens grass are distilled. And then distilled liquid and residua are collected. The residua and the residual liquid after distillation being added with a hepatitis grass and a climbing nightshade are decocted three times. The decoction liquid is combined and concentrated to a thick concentration. A 95 percent ethanol is diluted to alcohol concentration of 60 percent to 70 percent. The drug liquid after sedimentation, filtration and concentration added with 95 percent ethanol are transferred to alcohol concentration of 75 percent to 80 percent and then are sedimentated and filtrated. The filtrate is concentrated. The drug liquid added with distilled water is frozenly precipitated, filtrated and concentrated. The combination of Chinese medicines is produced out after a combination of the distilled liquid of the hypericum forsythia and the bidens and the decoction liquid of the hepatitis grass and the climbing nightshade are combined. The combination of Chinese medicines has a cure rate of about 90% for a viruses and bacterial infectious disease of poultry, can be used to prepare the animal drug for treating duck viral hepatitis and chicken newcastle disease and has little side effect, safe use and fast absorption.

An objective of the present invention is to provide compounds of formula (I) or their pharmacologically acceptable salts or solvates wherein A represents aryl while R₁ represents a five- or six-membered monocyclic heterocyclic group, or A represents a four- to six-membered monocyclic heterocyclic group while R₁ represents aryl or a five- or six-membered monocyclic heterocyclic group; R₂ represents a hydrogen atom or C_1-6 alkyl; R₃ represents C_1-6 alkyl or C_3-6 cycloalkyl-C_1-4 alkyl; R₄, R₅, and R₆ represent a hydrogen atom; R₇ represents C_1-6 alkyl; and m is 1 to 3. The compounds are novel lincosamide derivatives that have a potent activity against resistant Streptococcus pneumoniae. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.

The invention provides application of tsaoko oil in preparation of a medicament for treating bacterial infection diseases. The invention provides a medicinal composition for treating bacterial infection diseases. The medicament has antibacterial activity on Gram positive bacteria and Gram negative bacteria, has strong bacteria inhibiting effect on medicament-resistant strains therein, has good antibacterial effect likewise in vivo, can effectively treat the infection diseases caused by various strains in clinical Gram positive bacteria and Gram negative bacteria, and provides a new medicament application selection for clinic.

The present invention relates to a method for providing bactericide or bacteriostatic, especially for treating disease due to bacterial infection. The method comprising administering a patient in need of such treatment a therapeutically effective amount of a compound of dextromethorphan or naloxone or a pharmaceutically acceptable salt or an analog thereof. The compound is applied to skin or mucosal surface of the patient. The invention also relates to a method of treating inflammation caused by suppressing secretion of TNF-alpha, IL-6, or MCP-1 from macrophage comprising administering a patient in need of such treatment a therapeutically effective amount of NADPH oxidase inhibitor.

The invention belongs to the technical field of medicament, and particularly relates to a compound shown in formula (I) (please see the formula (I) in the description), and acceptable salt, ester or stereoisomer of the compound in pharmacy. R1, R2, a ring A and a ring B are defined in the description. The invention further relates to a preparation method, pharmaceutical preparations and pharmaceutical compositions of the compounds, and application of the compounds in preparation of medicines for treating and preventing bacterial infectious diseases.

The invention relates to application of patchouli alcohol in preparing medicines treating bacteria infectious diseases and further provides a medicine composition treating the bacteria infectious diseases. The patchouli alcohol has excellent inhibitory activity to pathogenic bacteria or conditional pathogenic bacteria and can effectively treat the bacteria infectious diseases, meanwhile, the patchouli alcohol can also effectively resist methicillin-resistant staphylococcus epidermidi drug-resistance bacteria, the pharmacodynamics activity of the patchouli alcohol equals to vancomycin, and therefore probability is provided for slowing or avoiding occurring of the drug-resistance bacteria.

Bacterial resistance to antibiotics is increasing worldwide creating a global threat. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, is a bacterial infectious disease that results in over one million deaths annually. The discovery outlined here involves a tablet composition for patient administration and subsequently a new paradigm in drug delivery vehicles in vivo and in vitro and is applied to existing TB antibiotics in order to increase their efficacy. The drug delivery system is a three component complex that is administered with the TB antibiotic or a combination of TB antibiotics. The components are a saccharide or saccharides, a transition metal ion or a combination of metal ions that can bind a nitrogen and/or oxygen atom(s), and a water soluble polymer capable of aggregating and enclosing the other constituents. The three component molecular delivery approach has demonstrated ability to overcome M. tuberculosis bacterial resistance to an existing antibiotic.

The invention belongs to biological technique field, relates to small molecular inhibitor against staphylococci tryptophanyl-tRNA synthetase (WRS), molecular structure of the inhibitor shown in formula I, method of the inhibitor as medicament for preventive or treating relevant bacterial disease. Biochemical and biological experiments have shown that the inhibitor has strong binding force with target protein staphylococcus epidermidis or Staphylococcus aureus tryptophanyl-tRNA synthetase, can inhibit the activity of the synthetase, inhibit the growth of staphylococcus epidermidis Staphylococcus aureus. It has no toxicity to mammalian cell. The inventive inhibitor can be used for preparing medicament for treating disease caused by staphylococci, and preparing into disinfectant liquid.

The invention relates to a Chinese herbal medicine feed additive for controlling main bacterial infectious diseases of freshwater fish. The Chinese herbal medicine feed additive is prepared from the following raw materials in parts by weight: 3-5 parts of purslane, 3-4 parts of dahurian patrinia herb, 2-3 parts of erodium stephanianum willd, 1-2 parts of Chinese gall, 1-2 parts of rosa laevigata michx, 1-2 parts of garlic and 1-2 parts of liquorice. The Chinese herbal medicine feed additive for controlling the main bacterial infectious diseases of the freshwater fish is used for controlling the main bacterial infectious diseases of the freshwater fish, and has the characteristics of being high in cure rate, good in effect, safe, free from toxic and side effects and convenient to take.

An azithromycin derivative, its medicinal acceptable salt and its usage are disclosed. In structural formula of medicinal acceptable salt, IR is -R1 or -A-R1; A is C1-5 alkylene, C2-5 vinylene, C2-5 acetylene, C3-6 naphthelene, 3-6 valence heterocyclene or C6-10 arylene containing 1-2 selected from N, O and S hetero-atom; R1 is 5-15 valence aromatic nucleus containing 0-3 selected from N, O and S hetero-atom, which can be substituted by various substituting group. It can be used to prepare medicines in treatment and prevention of infectious diseases.

The invention relates to lysobactin amides and methods for their preparation, as well as their use for manufacturing medicaments for the treatment and/or prophylaxis of diseases, in particular bacterial infectious diseases.

The invention relates to a Chinese herbal medicinal fermented extract liquid for preventing and treating bacterial diseases of freshwater fish and a preparation method of the Chinese herbal medicinal fermented extract liquid. The Chinese herbal medicinal fermented extract liquid is prepared by adding a bacillus bacterium liquid to a traditional Chinese medicinal extract liquid for airtight anaerobic fermentation. The traditional Chinese medicine is prepared from the following components in parts by weight: 2-5 parts of coptis chinensis, 3-6 parts of cortex phellodendri, 5-10 parts of humifuse euphorbia herb, 1-2 parts of fructus forsythia and 1-3 parts of liquorice. The Chinese herbal medicinal fermented extract liquid belongs to a natural medicine, is free of toxic or side effect, low in treatment cost, high in recovery rate, safe, and convenient to use, and is mainly used for treating main bacterial infectious diseases of the freshwater fish.