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Rapid Acting and Long Acting Insulin Combination Formulations

A combined rapid acting-long acting insulin formulation has been developed wherein the pH of the rapid acting insulin is decreased so that the long acting glargine remains soluble when they are mixed together. In the preferred embodiment, this injectable basal bolus insulin is administered before breakfast, provides adequate bolus insulin levels to cover the meal, does not produce hypoglycemia after the meal and provides adequate basal insulin for 24 hours. Lunch and dinner can be covered by two bolus injections of a fast acting, or a rapid acting or a very rapid acting insulin. As a result, a patient using intensive insulin therapy should only inject three, rather than four, times a day. Experiments have been performed to demonstrate the importance of the addition of specific acids to hexameric insulin to enhance speed and amount of absorption and preserve bioactivity following dissociation into the monomeric form by addition of a chelator such as EDTA. As shown by the examples, the preferred acids are aspartic, glutamic and citric acid. These are added in addition to a chelator, preferably ethylenediaminetetraacetic acid (EDTA). The results show that the citric acid formulation was more effective at dropping the blood glucose rapidly than the identical rapid acting formulation prepared with HCl in swine. Charge masking by the polyacid appears to be responsible for rapid insulin absorption. EDTA was not effective when used with adipic acid, oxalic acid or HCl at hastening the absorption of insulin. These results confirm the results seen in clinical subjects and patients with diabetes treated with the rapid acting insulin in combination with citric acid and EDTA.
Owner:ELI LILLY & CO

Hyper-spectral image classification method based on recurrent neural network

The invention discloses a hyper-spectral image classification method based on recurrent neural network with the object to solving the problems that in prior art, the input characteristic determination ability is weak and that the extraction of local spatial characteristics is not complete. The method comprises the following steps: 1) extracting the spatial texture characteristics and the sparse representation characteristics of a hyper-spectral image and piling and combining them as the low-level characteristics; 2) extracting from the low-level characteristics the sample local spatial sequence characteristics; 3) according to the local spatial sequence characteristics, creating a recurrent neural network model; and utilizing the training sample local spatial sequence characteristics to train the recurrent neural network model parameters; and 4) inputting the testing sample local spatial sequence characteristics into the well-trained recurrent neural network model; obtaining the highly abstract high-level semantic characteristics and obtaining the classification information of the testing sample. According to the deep learning method of the invention, the correct efficiency for hyper-spectral image classification is increased and the method can be used for vegetation investigation, disaster monitoring, map making and intelligence obtaining.
Owner:XIDIAN UNIV

Rotary servovalve and control system

An improved rotary servovalve system employs a rotary magnetic solenoid having an armature that includes at least one permanent magnet. The armature is rotatable relative to a stator formed as an electromagnet which is energizable to create alternative electromagnetic fields having opposite polarities from each other. When deenergized, the stator allows the armature to return to a neutral, null position from positions of extreme rotation in opposite angular directions due to the magnetic force of the permanent magnet of the armature. The armature is coupled to carry a movable valve element in angular rotation therewith, so that flow through the servovalve of the system can occur in alternative directions. Also, the valve element is biased toward a position in which all of the valve ports are closed when power is removed from the rotary solenoid. The control circuit employed in the rotary servovalve system expands the bandwidth of response of the solenoid actuator by compensating for frequency variations in the input command signal and in the feedback signal. This compensation is achieved utilizing a combined proportional, integral, and differential amplification circuit. Also, imbalance of fluid forces within the servovalve mechanism can be avoided by utilizing a pair of inlet orifices, a pair of outlet orifices, a pair of first fluid control orifices, and a pair of second fluid control orifices. The orifices within each pair are located on opposite sides of the valve housing from each other.
Owner:WOODWORTH RAYMOND DEXTER
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