38results about How to "Reduce bleeding risk" patented technology

The invention belongs to the technical field of computer-aided drug screening, discloses a computer-aided drug screening method, system or equipment based on PARP-1 and PAD4, and provides a screening method, system and equipment for screening anti-lung cancer thrombosis drugs based on PARP-1 and PAD4 and a computer readable storage medium for the field for the first time. The invention provides an efficient, accurate and rapid screening method for research and development of new drugs for resisting lung cancer thrombosis, and provides a new research direction and strategy for development of new drugs for reducing tumor thrombosis without increasing bleeding risk.

The present invention provides an artificial blood vessel that is resistant to bending and can be punctured at will. The artificial blood vessel includes a blood vessel wall and a blood vessel cavity; according to the radial outward direction of the blood vessel cavity, the blood vessel wall includes a blood vessel wall inner layer, a blood vessel wall middle layer and a blood vessel wall outer layer that are sequentially connected in a bonded manner; the blood vessel wall middle layer includes a puncturable support layer with a grid structure; the puncturable support layer includes a support rib trunk and branch lines extending from the side surface of the support rib trunk and side branches extending from the branch line surface. The artificial blood vessel is provided with a silica gel or polyurethane grid structure in the middle layer, so that the support rib trunk has the performance of being puncturable at will, and the bending resistance of the tube body is improved, and the effective puncture area of ​​the tube body is increased; the grid structure in the middle layer of the blood vessel wall can provide the blood vessel wall with automatic pinhole closing performance through the mutual auxiliary pulling effect of the support rib trunk, branch lines and side branches, thereby reducing the risk of blood leakage in the blood vessel wall after the puncture needle is pulled out.

A ventricular assist device that can be used for ventricular aneurysm includes a stent, the stent having a first end and a second end opposite to each other, a polymer film attached to the first end of the stent, a base provided at the second end of the stent, and a force-bearing portion formed between the first end and the second end of the stent, which can spontaneously adapt to the contraction and relaxation movements of the heart. That is, when the force-bearing portion contracts radially under force, the stent stretches axially; when the external force disappears and the force-bearing portion is not radially stressed, the stent returns to its original state. A skirt is provided at the edge of the polymer film, and one end of the skirt away from the polymer film is reversely adhered to the polymer film. When the stent enters the ventricle, the portion of the skirt that is reversely adhered to the polymer film is separated from the polymer film and adsorbed to the ventricular cavity wall, thereby reducing or even solving the problem of residual leakage after surgery.

The invention discloses a burn wound eschar abrading device for surgical debridement, which relates to the technical field of eschar abrading devices and comprises a shell, an arc eschar abrading surface fixed at the bottom of the shell, a motor arranged at the top of the shell and a partition plate fixedly connected in the shell. The scab abrading tool bit is exposed out of the scab abrading face and can adjust the contraction angle of the tool bit in a self-adaptive mode, the oil pressure control assembly contracts the scab abrading tool bit in a self-adaptive mode based on the radian of the wound scab, the scab abrading driving structure starts and stops rotation of the scab abrading tool bit through the oil pressure control assembly, and the dust collection assembly is fixed to the center of the bottom of the partition plate. The eschar abrading tool bits are distributed in the circular array and rotate oppositely in pairs, the rotating directions of the opposite eschar abrading tool bits are opposite, the eschar abrading tool bits counteract and reduce shaking of the skin and the wound eschar in the friction direction of the eschar abrading tool bits, continuous tearing between the wound eschar and skin tissue is effectively avoided, and the healing effect of the skin is improved. And the discomfort of the patient and the risk of secondary injury of the wound surface caused by tearing the connection between the wound surface scab and the tissue due to high-speed shaking are reduced.

The utility model provides a kind of nipple cutting balloon dilatation catheter, comprising: the balloon part of being arranged in the front part of catheter, the tube wall of the balloon part is wrapped with balloon, the outer surface of the balloon is equipped with multiple knife filaments, and the knife filament is used to be connected with high frequency generator.The utility model can be sent into or pulled out duodenal nipple in the guide of guide wire, and dilate duodenal nipple, when nipple sphincter stenosis appears, handle joint connects high frequency generator, and the knife filament on the surface of balloon can carry out electroincision effect to the tissue of stenosis, increase stenosis dilatation efficiency and effect.

This invention relates to a pharmaceutical composition and its application for treating acute ischemic stroke. The pharmaceutical composition for treating acute ischemic stroke comprises separately packaged tissue-type plasminogen activator citPA5 and a platelet aggregation inhibitor. Its beneficial effects include significantly improving cerebral blood flow recovery, shortening thrombolysis time, reducing infarct volume, and improving neurological function without increasing the risk of bleeding, demonstrating a good synergistic thrombolytic effect.

This invention relates to the field of biomedicine, specifically to the application of banana fruit extract in the preparation of anticoagulant or antithrombotic drugs. The banana fruit extract provided by this invention contains flavonoids, polyphenols, polysaccharides, hydroxyanthraquinones, triterpenoids, and other components. Flavonoids and polyphenols have been widely proven to have anti-inflammatory and antioxidant effects, which can synergistically enhance the anticoagulant effect. The high potassium content of banana fruit can indirectly improve vascular function by regulating sodium-potassium balance. The banana fruit extract provided by this invention can inhibit platelet production or promote platelet metabolism, prolong clotting time, and inhibit platelet aggregation. Its natural plant components interfere with platelet aggregation by inhibiting the production of thromboxane A2, achieving anticoagulant and antithrombotic effects. The mechanism of action of banana fruit extract differs from traditional anticoagulants such as heparin, reducing the risk of bleeding. Its natural component characteristics provide a direction for the development of novel plant-derived anticoagulant drugs.

The application discloses a production process of a three-breaded gold-plated gold finger, which is connected to the front end of the gold finger in the form of outer pull lead + silk screen wet film, makes the gold finger conductive with the whole PCB board surface, completes the production of the gold-plated gold finger in the form of electroplated nickel gold, then etches off the lead, and then carries out the production of the post-process; the main key points of the process are as follows: the quality of the silk screen wet film, the temperature and time of pre-baking, the exposure energy, the parameters during the plating of the gold finger, and the quality during the etching of the lead; the production process is simple and easy to implement, optimizes the production process of the three-breaded gold-plated gold finger, solves the lead residue caused by the traditional hand tearing lead process and the abnormal plating caused by the dry film pressing or blue glue pressing process, and the produced gold finger has better operability, higher yield and better quality, and can be mass-produced.

The application provides a method and equipment for optimizing a needle channel of a postoperative implantation plan. The method comprises the following steps: S1, constructing a three-dimensional coordinate system of an object based on CT or MRI images, and reconstructing three-dimensional space information of PTV and OAR; S2, setting a surface needle insertion surface position and range of the object in the three-dimensional coordinate system of the object, calculating all needle paths according to the three-dimensional spatial position relationship of PTV and OAR, combining the needle size and the physical restriction condition between the needle channels; S3, defining a penalty function model, calculating the position relationship between the prescription dose line and PTV and OAR in the three-dimensional space according to the dose distribution and the attenuation characteristics of the radiation source, and generating the penalty function model; S4, defining the number of needles, calculating the penalty function values of different needle number combinations, and taking the needle combination and path corresponding to the minimum function value as the optimal scheme. The application can reduce the normal tissue damage of implantation treatment and improve the efficiency and curative effect.

The utility model relates to the technical field of delivery supplies, in particular to a bellyband type sandbag sleeve which comprises a bandage, a first hook-and-loop fastener is mounted at one end of the bandage, a first loop-side hook-and-loop fastener is mounted at the other end of the bandage, the bandage is transversely bound to the waist of a patient, and the end of the bandage is fixedly connected with the first loop-side hook-and-loop fastener through the first hook-and-loop fastener. The middle of the bandage is connected with a first placing bag, and the upper portion of the bandage is connected with a second placing bag. According to the bellyband type sandbag sleeve, stable fixation and effective compression of the sandbag on the belly wound and the bottom of the uterine opening of a patient are achieved, and the nursing effect after delivery is remarkably improved. Specifically, according to the bellyband type sandbag sleeve, the combination of the binding bands and the hook-and-loop fasteners is adopted, so that the bellyband can be transversely bound to the waist of a patient, and rapid and firm fixation is achieved through the cooperation of the first thorn face hook-and-loop fasteners and the first loop face hook-and-loop fasteners. The fixing mode is easy and convenient to operate, flexible adjustment can be conducted according to the waistline of the patient, and using comfort and applicability are improved.

The invention discloses a single-crystal magnesium alloy wire for acupoint catgut embedding and weight losing and a preparation method of the single-crystal magnesium alloy wire, the chemical composition expression of the single-crystal magnesium alloy wire is Mg-yM-zR, in the formula, y and z represent the mass fraction of M and the mass fraction of R in magnesium alloy respectively, y is larger than or equal to 1.2 and smaller than or equal to 1.7, z is larger than or equal to 0.3 and smaller than or equal to 0.8, and the balance is Mg; m is one of Sr, Ce and Co, and R is one of Ge, Sm and Dy; the wire is prepared through the processes of smelting and casting, homogenizing treatment, hot extrusion, multi-pass cold drawing, intermediate annealing and zone smelting and directional solidification, and has uniform and controllable degradation rate, excellent mechanical property and biocompatibility; after the catgut embedding slimming agent is embedded into the acupuncture point of a human body, fat metabolism is promoted through mild and lasting physical stimulation and chemical ion regulation, intergranular corrosion and premature fracture caused by a polycrystalline structure are avoided, and the safety and durability of a catgut embedding slimming therapy are improved.

The utility model discloses a kind of delivery sheaths, it is related to medical instrument technical field, including sheath tube, sheath tube has sheath tube distal end first curved section, sheath tube distal end second curved section, sheath tube distal end third curved section and sheath tube main body section in turn from the distal end of sheath tube to the proximal end of sheath tube on sheath tube, the center line of sheath tube distal end first curved section and the center line of sheath tube distal end second curved section are on first plane, the center line of sheath tube distal end third curved section and the center line of sheath tube main body section are on second plane, the included angle between second plane and first plane is greater than 0 and less than 90 °;The center line of sheath tube distal end third curved section can be parallel with the center line of aortic arch, the outlet on sheath tube distal end first curved section can be directly opposite aortic valve orifice;The utility model can effectively avoid blood vessel or valve injury.

The utility model discloses a skin expanding device adopting a blunt separation method, which belongs to the technical field of minimally invasive surgery and comprises a blunt separation handle, a thick flaring needle and a thin flaring needle. The thick flaring needle is detachably connected with the blunt separation handle; the fine flaring needle is detachably connected with the blunt separation handle; the thick flaring needle and the thin flaring needle are located on the upper side and the lower side of the blunt separation handle respectively. The thick flaring needle, the thin flaring needle and the blunt separation handle are respectively provided with a through guide wire channel. The skin expanding device adopting the blunt separation method has the advantages that a puncture opening does not need to be cut and expanded again, and secondary damage to the puncture opening is avoided.

The application provides an AI treatment decision system for liver cirrhosis acute variceal hemorrhage, relates to the technical field of treatment decision, extracts a transient characteristic indicator of blood flow pressure from a pressure fluctuation signal, predicts a transient pressure peak of the portal vein blood flow during acute variceal hemorrhage through the transient characteristic indicator and a blood flow dynamic model, predicts a quasi-steady pressure field of the portal vein blood flow during acute variceal hemorrhage according to the gradient distribution of the portal vein blood flow pressure and an initial treatment strategy of acute variceal hemorrhage, performs multi-scale coupling on the transient pressure peak and the quasi-steady pressure field to obtain a coupling characteristic of the portal vein blood flow, and then uses the coupling characteristic of the blood flow pressure to perform hierarchical coupling adjustment on the treatment strategy of liver cirrhosis acute variceal hemorrhage. Based on the above scheme, hierarchical coupling of the treatment strategy of liver cirrhosis acute variceal hemorrhage can be realized, so that the prediction accuracy of the portal vein blood flow pressure during acute variceal hemorrhage can be improved.

The invention relates to a bronchoscope frozen lung biopsy and hemostasis integrated balloon catheter, belongs to the technical field of medical instruments, and solves the problems that in the prior art, operation steps are complicated and difficult, and a biopsy sample of a lung tip part is accurately obtained. The bronchoscope frozen lung biopsy and hemostasis integrated balloon catheter comprises a catheter body, wherein the catheter body is provided with a catheter head end and a catheter tail end; a working hole channel, a balloon channel and a guide wire channel which are independent from one another are integrated on the catheter main body; the working hole channel is configured as a channel when the freezing probe performs biopsy operation and is used for spraying a hemostatic medicine to a hemostatic part in an airway; a medicine balloon is arranged at the head end of the catheter, hemostatic particles are arranged on the outer surface of the medicine balloon, and the medicine balloon is communicated with the balloon channel and is configured to be inflated to expand the medicine balloon to achieve compression hemostasis; and a guide wire is arranged in the guide wire channel and is configured to guide the catheter main body to a target position. According to the application, the functions of freezing biopsy and instant hemostasis are integrated.

The invention discloses a low-molecular-weight sulfuric acid galactan derivative, a preparation method thereof and application of the low-molecular-weight sulfuric acid galactan derivative in preparation of anticoagulant and / or antithrombotic drugs. The low-molecular-weight sulphated galactan derivative is prepared by taking red algae-derived polysaccharide as a raw material through degradation, sulfation modification and purification, and anticoagulant activity research on the low-molecular-weight sulphated galactan derivative shows that the low-molecular-weight sulphated galactan derivative has remarkable in-vivo and in-vitro anticoagulant activity, and can be used for preparing the low-molecular-weight sulphated galactan derivative. Moreover, the compound has a relatively strong selective inhibition effect on an endogenous blood coagulation pathway, is low in bleeding risk and can be used for preventing and / or treating thrombotic related diseases. The polypeptide has the potential of being developed into in-vivo and in-vitro anticoagulant / antithrombotic drugs, and has a wide market application prospect.

The invention provides an application of RCL-M1A and / or RCL-M8H in preparation of drugs for preventing and / or treating venous thrombosis and embolism, the RCL-M1A and / or RCL-M8H is adopted to simulate the occurrence and development of VTE by applying a mouse inferior vena cava thrombosis model, and it is found that the RCL-M1A and / or RCL-M8H inhibits venous thrombosis by inhibiting platelet and neutrophil extracellular traps (NETs). Meanwhile, the bleeding risk is not increased, and the compound can be applied to preparation of drugs for preventing and / or treating venous thrombosis and embolism.

This invention relates to the field of medical device technology, and more particularly to a deep brain electrode implantation path planning system integrating dynamic navigation and force feedback. The system includes: a power supply module, a multimodal image detection and preprocessing unit module, an intelligent path planning and dynamic navigation control module, a force feedback execution and electrode implantation module, and an electrophysiological verification and human-computer interaction module. The power supply module supplies power to each module. The multimodal image detection and preprocessing unit module is used to acquire and preprocess multimodal images to construct a three-dimensional brain anatomical model. The intelligent path planning and dynamic navigation control module is used to generate the optimal implantation path and compensate for intraoperative brain displacement deviation in real time. The force feedback execution and electrode implantation module is used to acquire brain tissue mechanical signals. In this invention, dynamic navigation and brain displacement compensation technology improve electrode implantation accuracy, and the triple target confirmation mechanism enhances target implantation accuracy and significantly reduces surgical revision rate.

The invention discloses a vaginal retractor device and a vaginal tension method for cervical conization annular suture, and relates to the technical field of medical instruments. According to the technical key points, the device comprises a supporting mechanism, a connecting assembly installed on the supporting mechanism, a lower pulling hook body longitudinally installed on the connecting assembly, a limiting mechanism transversely installed on the connecting assembly and a pair of side pulling assemblies symmetrically installed at the upper end of the limiting mechanism, and the side pulling assemblies and the lower pulling hook body are located on the same vertical plane; the lower drag hook body is located below the symmetrical center line of the side pull assembly, and the drag hook ends of the side pull assembly and the lower drag hook body are both arranged backwards; the device is good in vagina stretching effect, and the cervix uteri of a patient can be exposed; the vagina can be stretched and supported in different directions by utilizing the inward retractor ends of the side pulling assembly and the lower retractor body, and the side pulling assembly and the lower retractor body can be limited and fixed and kept in a stretched and supported state by utilizing the connecting assembly to be matched with the limiting mechanism, so that the surgical suture of related personnel is facilitated.

A prostate puncture device capable of achieving ablation comprises an outer sheath, a rotary cutter and a microwave ablation probe, the outer sheath comprises a hollow sheath tube and a hollow connecting column, and a semi-cylindrical groove hole is formed in the outer side surface of the front portion of the hollow sheath tube; a hollow through hole is formed in the middle of the hollow connecting column; the rotary cutter comprises a connecting rod, the front end of the connecting rod is connected with a hollow pipe body, and a semi-cylindrical cutting notch is formed in the side surface of the hollow pipe body; the rear end of the connecting rod is fixedly connected with a rotating handle; the microwave ablation probe comprises a probe body and a limiting block, after the probe body is movably inserted into the hollow sheath tube, a radiation window of the probe body corresponds to the semi-cylindrical groove hole, and the limiting block is fixedly installed at the rear end of the probe body and movably connected into the hollow through hole. According to the utility model, the rotary cutter is firstly inserted into the hollow sheath tube to carry out precise rotary cutting on the prostate tissue to obtain an expected tissue sample, then the rotary cutter is withdrawn, and then the microwave ablation probe is inserted to carry out efficient ablation on a target area, so that on the premise of multiple sampling, the bleeding risk is reduced, and the defects in the prior art are overcome.

This invention discloses a puncture positioning device for oncology, relating to the field of medical device technology. It includes a puncture needle assembly, a self-sealing assembly, a drug injection mechanism, and a disposable locator. The puncture needle assembly comprises a puncture needle tube and a puncture needle core. The puncture needle tube has a hollow structure, and the puncture needle core slidably passes through the inner wall of the puncture needle tube. The front end of the puncture needle tube has a puncture tip for easy penetration of human tissue. The self-sealing assembly includes an elastic sealing ring fixedly connected to the surface of the puncture needle tube. This invention, by setting an elastic sealing ring and a sliding sleeve on the surface of the puncture needle tube, allows the sliding sleeve to slide along the axial direction of the puncture needle tube. When the puncture needle penetrates the target tissue, it pushes the sliding sleeve forward, and a movable push rod compresses the elastic sealing ring, causing it to expand radially. This allows the edge of the elastic sealing ring to make close contact with the tissue wall, achieving closure of the needle tract and effectively reducing the risk of pneumothorax and bleeding.

An anus medicine feeding device comprises a medicine pushing device cylinder, a medicine containing head is installed at the front end of the medicine pushing device cylinder, an elastic clamping opening is formed in the medicine containing head, a suppository is clamped by the elastic clamping opening, a push rod is installed in the medicine pushing device cylinder, and the suppository in the elastic clamping opening is contained in the anus when the push rod is compressed. Compared with the prior art, according to the anus medicine feeding device, the suppository is clamped by the elastic clamping opening and contained in the anus, the suppository can be guided to be contained in the correct position and depth through the tubular conical design and the positioning design, and the situation that a patient pains due to the fact that an anal tube is incarcerated due to the incorrect position or the suppository falls out and is contained in the anus repeatedly is avoided; meanwhile, the medicine placing head is made of silica gel, is soft in texture, can effectively protect the wound surface when being placed in the anus, and reduces pain and bleeding risks.

The invention discloses a plugging device for an aortic dissection crevasse, and the plugging device comprises at least two opposite clamping bodies, and the clamping bodies are arranged to have magnetism or are provided with magnetic parts; the connecting body is used for connecting the two opposite clamping bodies; after the clamping bodies clamp the crevasse position, the clamping bodies attract each other through the magnetic force effect of the magnetic component or the clamping bodies and are tightly attached to the interlayer inner film and the crevasse, and blocking of the crevasse is achieved. The invention provides a special instrument for closing a crevasse treatment interlayer, the problems that the interlayer crevasse treatment difficulty is high, the plugging effect is limited, residual shunt occurs and the like are solved, the plugging device is mainly provided with a magnetic component or a magnetic component, and a false cavity can be automatically clamped to close a crevasse through the magnetic attraction effect of magnetic force.

The utility model discloses a kind of endoscope anastomat nail abutment and endoscope anastomat, nail abutment includes nail abutment body, cutting knife sliding groove is equipped in the middle part of nail abutment body, at least four rows of nail groove groups with cutting knife groove as center symmetry arrangement are arranged on the surface of nail abutment body, the arrangement direction of at least two rows of adjacent nail groove in nail groove group is cross arrangement. By the above mode, the utility model can make suture nail line more closely by optimizing nail groove arrangement mode, ensure that suture site airtightness and connection tightness, can cope with complex tissue environment, adaptively suture uneven tissue, substantially reduce tissue leakage or hemorrhage risk, reduce complication, improve surgical suture effect.

The utility model relates to a compression hemostat for a radial artery puncture point. The compression hemostat comprises a compressor base, two elastic fixing belts, a finger binding belt, a compression air bag, an inflation branch pipe, an inflation device and a pressure gauge. Wherein the compressor base is respectively connected with the two elastic fixing belts and the finger binding belt; correspondingly, compression air bags are arranged on the two elastic fixing belts and the finger binding belt. Wherein an inflation branch pipe is further arranged in the compressor base; correspondingly, the air inflation branch pipes are connected with the two elastic fixing bands, the compression air bags in the finger binding bands and the air inflation device. The device has the advantages that the device is simple in structure and convenient to use, the bleeding risk is reduced, and the postoperative comfort of a patient is improved; meanwhile, the finger binding belt structure can be tightened under the action of the compression air bag, the hemostasis effect is better, the compression force can be adjusted at any time according to the use requirement and the feeling of a patient, and operation is easy.

The utility model belongs to the technical field of hemostasis devices, particularly relates to a pressing hemostasis device, and aims to solve the problems that in the process of driving a pressing plate to move downwards through a threaded rod, the pressing degree of the device on a wound of a patient is inconvenient to judge, and medical workers are difficult to decompress the wound step by step. In order to solve the problems that in the prior art, in the prior art, in the prior art, the device is fixed to the skin of a patient through a self-adhesive non-woven fabric bandage, the device is difficult to take down, and in the uncovering process, fine hair of the patient is dragged, and the pain of the patient is aggravated, the following scheme is provided: the device comprises a U-shaped mounting plate, and two sides of the U-shaped mounting plate are fixedly provided with a first fixing band and a second fixing band respectively; and a cylindrical barrel is fixedly arranged in the center of the U-shaped mounting plate. The compression degree observation assembly is arranged, so that medical staff can visually judge the compression degree and carry out decompression operation step by step, in addition, the device further adopts the design of the U-shaped comfortable pad, the buffer gasket and the like, and the wearing comfort of a patient is improved.

The application discloses a self-derived protein anticoagulant coating and a preparation method and application thereof. The coating utilizes the oxidation of hydrogen peroxide generated by the reaction of an oxidizing agent or a reducing agent with oxygen in the air, is based on the endogenous active center (such as hematin) removal mechanism of self-extracted proteins (such as hemoglobin), induces the oxidative self-assembly of the proteins, and loads an anticoagulant in the assembly process to form a protein-anticoagulant composite nanofilm. The application utilizes the self-proteins to avoid the transmission risk of pathogens such as HIV, PERVs and prions from the source; the preparation method is simple and rapid, and the obtained coating has excellent adhesion stability, good biocompatibility and anti-biofouling capacity on the surface of various substrates. In-vitro and in-vivo experiments prove that the coating has superior anticoagulant performance, reduces the risk of bleeding and liver and kidney toxicity, and can be used for the surface modification of blood-contacting medical devices such as a heart stent, an artificial blood vessel, a central venous catheter and an extracorporeal oxygenator.

The sheathing canal assembly comprises a sheathing canal and a valve bank, the valve bank comprises a plurality of valve structures, each valve structure is provided with a valve cavity, a first communication opening and a second communication opening, the first communication opening and the second communication opening are communicated with the valve cavity, a hemostasis valve is arranged in each valve cavity, and the hemostasis valves are used for sealing the second communication openings. The hemostasis valve is configured to allow an instrument to pass through the hemostasis valve and the first communication port from one side of the second communication port; wherein the plurality of valve structures comprise a first valve and at least one second valve, a first communication port of the first valve is communicated with the sheath tube, and a first communication port of the second valve is selectively communicated with a second communication port of the first valve or a second communication port of another second valve. By means of the technical scheme, the sheath tube assembly can reduce the risk of blood leakage of the sheath tube assembly when an operator enables instruments such as a catheter or a guide wire to penetrate through the hemostasis valve in the sheath tube assembly, and the operation safety, convenience and efficiency can be improved.

The invention belongs to the technical field of polypeptide preparation and biological medicine, and particularly relates to an antithrombotic polypeptide PM4 and application thereof. On the basis of original polypeptide obtained from transcriptome of salivary gland of poecilobdella manillensis, an amino acid fragment is intercepted from the original polypeptide, and {d-Phe}-PRP is added at the N end of the intercepted amino acid fragment through a synthetic strategy of hirudin analogue bivalirudin medicine; finally, the {d-Phe}-PRP and the intercepted amino acid fragment are connected through the connecting polypeptide to obtain the antithrombotic polypeptide PM4. The antithrombotic polypeptide PM4 can inhibit the activity of thrombin, is small in bleeding risk, shorter in in-vivo half-life period and higher in safety, and has remarkable resistance to thrombus including arterial thrombus; meanwhile, the sequence of the antithrombotic polypeptide PM4 is shorter than that of the original sequence, and the antithrombotic polypeptide PM4 is easier to synthesize.

The invention relates to the technical field of interventional therapy, and discloses a nerve intervention thrombolysis device which comprises a medicine guide inner cannula mechanism and a supporting outer cannula mechanism, the supporting outer cannula mechanism comprises a cannula unit, a sealing control unit, a disinfection isolation unit and a cannula pushing unit, the sealing control unit is fixedly installed at one end of the cannula unit, and the disinfection isolation unit is fixedly installed at the other end of the cannula unit. The disinfection and isolation unit is fixedly installed on the surface of the sealing control unit, and the tube pushing unit is fixedly arranged on one side of the sealing control unit. According to the nerve intervention thrombolysis device, during thrombolysis, the blocking number of the hole sealing liquid bag to the medicine discharging side holes can be adjusted through stretching and retracting of the end of the inner sleeve body in the outer sleeve body, so that the using number and the arrangement length of the medicine discharging side holes can be flexibly adjusted according to the thrombus position and range, and dosage control over thrombolysis medicine is facilitated; the ineffective thrombolysis range is reduced, the probability of excessive use of thrombolysis drugs is reduced, the whole body bleeding risk is reduced, and the safety is improved.