17results about How to "Reduce bleeding risk" patented technology

The utility model provides a kind of nipple cutting balloon dilatation catheter, comprising: the balloon part of being arranged in the front part of catheter, the tube wall of the balloon part is wrapped with balloon, the outer surface of the balloon is equipped with multiple knife filaments, and the knife filament is used to be connected with high frequency generator.The utility model can be sent into or pulled out duodenal nipple in the guide of guide wire, and dilate duodenal nipple, when nipple sphincter stenosis appears, handle joint connects high frequency generator, and the knife filament on the surface of balloon can carry out electroincision effect to the tissue of stenosis, increase stenosis dilatation efficiency and effect.

This invention relates to a pharmaceutical composition and its application for treating acute ischemic stroke. The pharmaceutical composition for treating acute ischemic stroke comprises separately packaged tissue-type plasminogen activator citPA5 and a platelet aggregation inhibitor. Its beneficial effects include significantly improving cerebral blood flow recovery, shortening thrombolysis time, reducing infarct volume, and improving neurological function without increasing the risk of bleeding, demonstrating a good synergistic thrombolytic effect.

This invention relates to the field of biomedicine, specifically to the application of banana fruit extract in the preparation of anticoagulant or antithrombotic drugs. The banana fruit extract provided by this invention contains flavonoids, polyphenols, polysaccharides, hydroxyanthraquinones, triterpenoids, and other components. Flavonoids and polyphenols have been widely proven to have anti-inflammatory and antioxidant effects, which can synergistically enhance the anticoagulant effect. The high potassium content of banana fruit can indirectly improve vascular function by regulating sodium-potassium balance. The banana fruit extract provided by this invention can inhibit platelet production or promote platelet metabolism, prolong clotting time, and inhibit platelet aggregation. Its natural plant components interfere with platelet aggregation by inhibiting the production of thromboxane A2, achieving anticoagulant and antithrombotic effects. The mechanism of action of banana fruit extract differs from traditional anticoagulants such as heparin, reducing the risk of bleeding. Its natural component characteristics provide a direction for the development of novel plant-derived anticoagulant drugs.

The application provides a method and equipment for optimizing a needle channel of a postoperative implantation plan. The method comprises the following steps: S1, constructing a three-dimensional coordinate system of an object based on CT or MRI images, and reconstructing three-dimensional space information of PTV and OAR; S2, setting a surface needle insertion surface position and range of the object in the three-dimensional coordinate system of the object, calculating all needle paths according to the three-dimensional spatial position relationship of PTV and OAR, combining the needle size and the physical restriction condition between the needle channels; S3, defining a penalty function model, calculating the position relationship between the prescription dose line and PTV and OAR in the three-dimensional space according to the dose distribution and the attenuation characteristics of the radiation source, and generating the penalty function model; S4, defining the number of needles, calculating the penalty function values of different needle number combinations, and taking the needle combination and path corresponding to the minimum function value as the optimal scheme. The application can reduce the normal tissue damage of implantation treatment and improve the efficiency and curative effect.

The invention discloses a single-crystal magnesium alloy wire for acupoint catgut embedding and weight losing and a preparation method of the single-crystal magnesium alloy wire, the chemical composition expression of the single-crystal magnesium alloy wire is Mg-yM-zR, in the formula, y and z represent the mass fraction of M and the mass fraction of R in magnesium alloy respectively, y is larger than or equal to 1.2 and smaller than or equal to 1.7, z is larger than or equal to 0.3 and smaller than or equal to 0.8, and the balance is Mg; m is one of Sr, Ce and Co, and R is one of Ge, Sm and Dy; the wire is prepared through the processes of smelting and casting, homogenizing treatment, hot extrusion, multi-pass cold drawing, intermediate annealing and zone smelting and directional solidification, and has uniform and controllable degradation rate, excellent mechanical property and biocompatibility; after the catgut embedding slimming agent is embedded into the acupuncture point of a human body, fat metabolism is promoted through mild and lasting physical stimulation and chemical ion regulation, intergranular corrosion and premature fracture caused by a polycrystalline structure are avoided, and the safety and durability of a catgut embedding slimming therapy are improved.

The utility model discloses a kind of delivery sheaths, it is related to medical instrument technical field, including sheath tube, sheath tube has sheath tube distal end first curved section, sheath tube distal end second curved section, sheath tube distal end third curved section and sheath tube main body section in turn from the distal end of sheath tube to the proximal end of sheath tube on sheath tube, the center line of sheath tube distal end first curved section and the center line of sheath tube distal end second curved section are on first plane, the center line of sheath tube distal end third curved section and the center line of sheath tube main body section are on second plane, the included angle between second plane and first plane is greater than 0 and less than 90 °;The center line of sheath tube distal end third curved section can be parallel with the center line of aortic arch, the outlet on sheath tube distal end first curved section can be directly opposite aortic valve orifice;The utility model can effectively avoid blood vessel or valve injury.

The application provides an AI treatment decision system for liver cirrhosis acute variceal hemorrhage, relates to the technical field of treatment decision, extracts a transient characteristic indicator of blood flow pressure from a pressure fluctuation signal, predicts a transient pressure peak of the portal vein blood flow during acute variceal hemorrhage through the transient characteristic indicator and a blood flow dynamic model, predicts a quasi-steady pressure field of the portal vein blood flow during acute variceal hemorrhage according to the gradient distribution of the portal vein blood flow pressure and an initial treatment strategy of acute variceal hemorrhage, performs multi-scale coupling on the transient pressure peak and the quasi-steady pressure field to obtain a coupling characteristic of the portal vein blood flow, and then uses the coupling characteristic of the blood flow pressure to perform hierarchical coupling adjustment on the treatment strategy of liver cirrhosis acute variceal hemorrhage. Based on the above scheme, hierarchical coupling of the treatment strategy of liver cirrhosis acute variceal hemorrhage can be realized, so that the prediction accuracy of the portal vein blood flow pressure during acute variceal hemorrhage can be improved.

This invention relates to the field of medical device technology, and more particularly to a deep brain electrode implantation path planning system integrating dynamic navigation and force feedback. The system includes: a power supply module, a multimodal image detection and preprocessing unit module, an intelligent path planning and dynamic navigation control module, a force feedback execution and electrode implantation module, and an electrophysiological verification and human-computer interaction module. The power supply module supplies power to each module. The multimodal image detection and preprocessing unit module is used to acquire and preprocess multimodal images to construct a three-dimensional brain anatomical model. The intelligent path planning and dynamic navigation control module is used to generate the optimal implantation path and compensate for intraoperative brain displacement deviation in real time. The force feedback execution and electrode implantation module is used to acquire brain tissue mechanical signals. In this invention, dynamic navigation and brain displacement compensation technology improve electrode implantation accuracy, and the triple target confirmation mechanism enhances target implantation accuracy and significantly reduces surgical revision rate.

The invention discloses a vaginal retractor device and a vaginal tension method for cervical conization annular suture, and relates to the technical field of medical instruments. According to the technical key points, the device comprises a supporting mechanism, a connecting assembly installed on the supporting mechanism, a lower pulling hook body longitudinally installed on the connecting assembly, a limiting mechanism transversely installed on the connecting assembly and a pair of side pulling assemblies symmetrically installed at the upper end of the limiting mechanism, and the side pulling assemblies and the lower pulling hook body are located on the same vertical plane; the lower drag hook body is located below the symmetrical center line of the side pull assembly, and the drag hook ends of the side pull assembly and the lower drag hook body are both arranged backwards; the device is good in vagina stretching effect, and the cervix uteri of a patient can be exposed; the vagina can be stretched and supported in different directions by utilizing the inward retractor ends of the side pulling assembly and the lower retractor body, and the side pulling assembly and the lower retractor body can be limited and fixed and kept in a stretched and supported state by utilizing the connecting assembly to be matched with the limiting mechanism, so that the surgical suture of related personnel is facilitated.

A prostate puncture device capable of achieving ablation comprises an outer sheath, a rotary cutter and a microwave ablation probe, the outer sheath comprises a hollow sheath tube and a hollow connecting column, and a semi-cylindrical groove hole is formed in the outer side surface of the front portion of the hollow sheath tube; a hollow through hole is formed in the middle of the hollow connecting column; the rotary cutter comprises a connecting rod, the front end of the connecting rod is connected with a hollow pipe body, and a semi-cylindrical cutting notch is formed in the side surface of the hollow pipe body; the rear end of the connecting rod is fixedly connected with a rotating handle; the microwave ablation probe comprises a probe body and a limiting block, after the probe body is movably inserted into the hollow sheath tube, a radiation window of the probe body corresponds to the semi-cylindrical groove hole, and the limiting block is fixedly installed at the rear end of the probe body and movably connected into the hollow through hole. According to the utility model, the rotary cutter is firstly inserted into the hollow sheath tube to carry out precise rotary cutting on the prostate tissue to obtain an expected tissue sample, then the rotary cutter is withdrawn, and then the microwave ablation probe is inserted to carry out efficient ablation on a target area, so that on the premise of multiple sampling, the bleeding risk is reduced, and the defects in the prior art are overcome.

This invention discloses a puncture positioning device for oncology, relating to the field of medical device technology. It includes a puncture needle assembly, a self-sealing assembly, a drug injection mechanism, and a disposable locator. The puncture needle assembly comprises a puncture needle tube and a puncture needle core. The puncture needle tube has a hollow structure, and the puncture needle core slidably passes through the inner wall of the puncture needle tube. The front end of the puncture needle tube has a puncture tip for easy penetration of human tissue. The self-sealing assembly includes an elastic sealing ring fixedly connected to the surface of the puncture needle tube. This invention, by setting an elastic sealing ring and a sliding sleeve on the surface of the puncture needle tube, allows the sliding sleeve to slide along the axial direction of the puncture needle tube. When the puncture needle penetrates the target tissue, it pushes the sliding sleeve forward, and a movable push rod compresses the elastic sealing ring, causing it to expand radially. This allows the edge of the elastic sealing ring to make close contact with the tissue wall, achieving closure of the needle tract and effectively reducing the risk of pneumothorax and bleeding.

The utility model discloses a kind of endoscope anastomat nail abutment and endoscope anastomat, nail abutment includes nail abutment body, cutting knife sliding groove is equipped in the middle part of nail abutment body, at least four rows of nail groove groups with cutting knife groove as center symmetry arrangement are arranged on the surface of nail abutment body, the arrangement direction of at least two rows of adjacent nail groove in nail groove group is cross arrangement. By the above mode, the utility model can make suture nail line more closely by optimizing nail groove arrangement mode, ensure that suture site airtightness and connection tightness, can cope with complex tissue environment, adaptively suture uneven tissue, substantially reduce tissue leakage or hemorrhage risk, reduce complication, improve surgical suture effect.

The application discloses a self-derived protein anticoagulant coating and a preparation method and application thereof. The coating utilizes the oxidation of hydrogen peroxide generated by the reaction of an oxidizing agent or a reducing agent with oxygen in the air, is based on the endogenous active center (such as hematin) removal mechanism of self-extracted proteins (such as hemoglobin), induces the oxidative self-assembly of the proteins, and loads an anticoagulant in the assembly process to form a protein-anticoagulant composite nanofilm. The application utilizes the self-proteins to avoid the transmission risk of pathogens such as HIV, PERVs and prions from the source; the preparation method is simple and rapid, and the obtained coating has excellent adhesion stability, good biocompatibility and anti-biofouling capacity on the surface of various substrates. In-vitro and in-vivo experiments prove that the coating has superior anticoagulant performance, reduces the risk of bleeding and liver and kidney toxicity, and can be used for the surface modification of blood-contacting medical devices such as a heart stent, an artificial blood vessel, a central venous catheter and an extracorporeal oxygenator.

The sheathing canal assembly comprises a sheathing canal and a valve bank, the valve bank comprises a plurality of valve structures, each valve structure is provided with a valve cavity, a first communication opening and a second communication opening, the first communication opening and the second communication opening are communicated with the valve cavity, a hemostasis valve is arranged in each valve cavity, and the hemostasis valves are used for sealing the second communication openings. The hemostasis valve is configured to allow an instrument to pass through the hemostasis valve and the first communication port from one side of the second communication port; wherein the plurality of valve structures comprise a first valve and at least one second valve, a first communication port of the first valve is communicated with the sheath tube, and a first communication port of the second valve is selectively communicated with a second communication port of the first valve or a second communication port of another second valve. By means of the technical scheme, the sheath tube assembly can reduce the risk of blood leakage of the sheath tube assembly when an operator enables instruments such as a catheter or a guide wire to penetrate through the hemostasis valve in the sheath tube assembly, and the operation safety, convenience and efficiency can be improved.

The utility model provides a kind of net basket stone extraction device with biliary tract flushing function, including catheter, fixed ring, guide wire, flush pipe, pipeline guide silk;Wherein, catheter is equipped with first lead-through cavity, and multiple second lead-through cavities;First through-hole is set in fixed ring middle part;Guide wire is worn in second lead-through cavity, and front end forms net basket;Flush pipe is installed in first lead-through cavity, with infusion cavity;Pipeline guide silk is worn in the infusion cavity of flush pipe. When using, the front end of catheter is sent to calculus place through endoscope;Physiological saline is injected in flush pipe, and calculus periphery adherend is washed;Then flush pipe is extracted, then guide wire is pushed to make net basket open and cover calculus, and is withdrawn with endoscope;After calculus is extracted, flush pipe is installed by pipeline guide silk, and is entered again to flush biliary tract and remove residue. The device reduces operation time and complexity, avoids multiple instruments cross into human body, and reduces biliary tract injury and bleeding risk.

The invention provides a sheep milk casein anticoagulant peptide as well as a preparation method and application thereof. The sheep milk casein anticoagulant peptide is VKETMVPK, VLPVPQK or EMPFPK. The invention solves the problems of low safety and high cost of the existing clinical anticoagulant drug; the high-valued utilization rate of sheep milk casein resource development is low; and the blank of the preparation technology of the sheep milk casein anticoagulant peptide is filled. The sheep milk casein inhibitory peptide provided by the invention has high safety, and avoids the defects of existing drug treatment; goat milk resource value is efficiently excavated, and resource waste is reduced; the technical blank is filled, and a systematic preparation system is established; the anticoagulant activity is clear and efficient, and the action mechanism is comprehensive; the application scene is wide and the market potential is great.

The invention discloses a polydopamine (PDA)-coated polylactic acid-glycolic acid (PLGA) targeted sustained release microsphere (Hep-coated PLGA-PDA MPs) loaded with heparin sodium, which is characterized in that the polylactic acid-glycolic acid microsphere (Hep-coated PLGA-PDA MPs) loaded with the drug heparin sodium is an inner core microsphere, and the outer part of the microsphere is also coated with a PDA layer. The invention also discloses a preparation method of the Hep-coated PLGA MPs, the microspheres have no burst release phenomenon within 2 hours of drug release, the release proportion of heparin sodium is 45.7-57.2% in 24 hours, and the microspheres have the characteristic of slow release. The microsphere disclosed by the invention can be used for developing an intravenous injection sustained-release agent for targeted therapy of thrombus.