117 results about "Connective tissue fiber" patented technology

The present invention relates to a part (2) intended to be used in association with an implant (4) which is itself intended to be secured in a jaw, this part comprising, in series from its distal end (20) towards its proximal end (21), a distal portion (22) for securing in the implant, an intermediate portion (23) for attachment to the epithelial and / or connective tissue, and a proximal portion (24), this part also comprising at least two zones whose surfaces have a different structure, the structure of the surface of at least one of these two zones, located in said intermediate portion (23), said first zone being ordered and repetitive, adapted to the growth of the epithelial tissue and / or the connective tissue and having engravings forming corrugations with a depth of less than 0.5 microns.

The invention discloses composite hydrogel bio-ink with a function of space-time delivery of double growth factors as well as a preparation method and application of the composite hydrogel bio-ink, and belongs to the technical field of biomedical materials and tissue engineering. According to the preparation method, imidazolyl-modified methacrylated gelatin and double-bonded PF127 are compounded, and meanwhile, free vascular endothelial growth factors and connective tissue growth factor-loaded PLGA microspheres are entrapped in a system, so that the bio-ink with excellent printability, high adhesion, swelling resistance and space-time delivery function is formed; the bio-ink physically has the advantages of high printing fidelity, low swelling property, high mechanical strength and strong tissue adhesion of a synthetic material; in biology, the system can be used as an intelligent carrier to realize programmed space-time delivery of various growth factors, so that complex cell biological behaviors are accurately arranged, and real regeneration of functional tissues is guided.

The invention relates to the technical field of preparation of stimuli-responsive hydrogel, in particular to sea cucumber ion skin imitating double-dynamic topology hydrogel as well as a preparation method and application of the sea cucumber ion skin imitating double-dynamic topology hydrogel. The thermo-sensitive poly (N-isopropylacrylamide) hydrogel is used as a continuous matrix and is used for simulating the dynamic adaptability of sea cucumber skin; and the ionic conductive microgel is used as a rigid dispersion phase and is used for simulating a collagenous fiber network of a connective tissue layer of the sea cucumber. The microgel is dispersed in the poly (N-isopropylacrylamide) hydrogel and is physically entangled with the poly (N-isopropylacrylamide) hydrogel to form a cross-linking point, so that a dynamic network of'rigid node-flexible matrix 'is constructed. The dynamic network structure endows the double-dynamic topological hydrogel with force and heat double toughening properties and ultralow mechanical hysteresis, so that the double-dynamic topological hydrogel has excellent elasticity, fatigue resistance, low hysteresis and strain rate insensitivity, and further shows wide application prospects in the fields of flexible sensing and wearable equipment.

An orally administered composition for treating or reducing damage to connective tissue or for treating or reducing inflammatory symptoms associated with damage to connective tissue includes a synergistic combination of (i) avocado / soybean unsaponifiables; and (ii) a lipoic acid or a salt or derivative thereof. A method for treating or reducing damage to connective tissue, for treating or reducing inflammatory symptoms associated with damage to connective tissue, or for reducing the level of one or more inflammatory mediators in connective tissue includes administering the orally administered composition to an avian or mammalian subject.

The present disclosure relates to methods of treating, preventing, or modulating diabetes in a patient in need thereof using a device for transplanting cells into a host body, specifically a method of treating diabetes in a patient in need thereof, comprising: implanting a device in the patient, wherein the device comprises: a porous scaffold comprising an immunologically compatible polymer mesh forming the walls of at least one chamber, an opening at either or both of a proximal end and a distal end of the chamber, at least one removable, non-porous plug configured to be positioned within the lumen of the at least one chamber, maintaining the device in the patient's body until the device is infiltrated with vascular and connective tissues; and infusing the chamber with cells, wherein at least some of the cells express insulin

The invention relates to a multifunctional collagen-based edible food packaging film with pH responsiveness and preparation, and belongs to the field of biodegradable packaging materials. The method comprises the following steps: swelling collagen, wherein the collagen is obtained by extracting animal tendons or connective tissues or animal skins; mixing the turbid liquid with a grape skin red pigment with pH responsiveness to obtain a collagen mixed solution; and adding the ganoderma lucidum hypha liquid into the collagen mixed liquid, pouring into a mold, and drying to obtain the pH-responsive multifunctional collagen-based food packaging film. The food film designed by the invention has pH responsiveness, the film can be changed from pink to yellow along with the change of environment pH from acidity to alkalinity, and the preservation and dynamic monitoring of food materials are realized; the film materials are all biodegradable materials, are green and environment-friendly, are simple in process, and have the advantages of high mechanical strength, excellent oxidation resistance and antibacterial property, greenness, environment friendliness and no toxicity.

Disclosed is a composition for treating a joint disease or a connective tissue disease, a composition for cartilage regeneration, or a composition for treating an inflammatory disease, each of the compositions containing dextran, poloxamer or a mixture thereof. The composition stays in the joint or connective tissue for a long time due to the shock-absorbing effect, coating effect or anti-inflammation effect, relieves the shock, covers a damaged portion in a specific manner thereto, or reduces inflammation of an adhered portion. Thus, the composition may be useful for the treatment of the joint disease, the connective tissue disease, or for the cartilage regeneration.

[Problem] To provide a new technical means that enables manufacturing a heated meat processed product containing a meat chunk having a good texture. [Solution] Provided is a method for manufacturing a heated meat processed product containing a chicken chunk, the method comprising a step for preparing a meat material to be processed, the meat material containing a chicken chunk, and a step for heating the meat material to be processed under heating conditions predetermined to achieve the following criteria: the center temperature of the chicken chunk reaches 85°C or higher; the degree of connective tissue degradation in the chicken chunk reaches 5% or more; and the yield of the heated meat processed product from the meat material to be processed (heated meat processed product / meat material to be processed) reaches 90 mass% or more.

The described system designed to promote the biological attachment of fibrous connective tissue to a bone implant features a bone implant with a scaffold defining a porous attachment surface, a suction port, and a manifold that distributes a negative pressure gradient across the attachment surface. The system also includes an extracorporeal vacuum pump and a percutaneous suction hose connecting the suction port of the implant to the vacuum pump. The implant is placed in the patient's body with connective tissue applied over the attachment surface, and the suction hose is attached and connected to the vacuum pump. The vacuum pump, operating outside the body, creates a negative pressure gradient over an extended period, promoting the growth of slow growing Sharpey's fibres for superior biological integration. A highly vascularised tissue graft, such as a pedicled muscle flap, may be applied adjacent to the avascular tendon to enhance endogenous growth factor migration.

Ultrasound emitting device for applying selective treatments to hypodermic tissue (adipose and connective tissue) in rejuvenation and / or body contouring processes, comprising an electrical pulse generator, an ultrasonic transducer (3), an electronic control unit (6) equipped with specific software that controls the frequency, voltage, and duty cycle of the pulse generator, and application means (4) for orienting and directing the acoustic field onto the area to be treated on the patient / user, wherein said transducer emits in each pulse an acoustic field with an energy density not exceeding 0.7W / cm2 and a minimum emission duration of 100ms. Preferably, the transducer emits either at a single frequency or in a frequency sweep, in a frequency range between 185 kHz and 333 kHz, and even more preferably at 244 kHz.

This invention provides an organ fibrosis-related micropeptide, OFMP, and its applications. This type of micropeptide, OFMP, is a translational product with endogenous biological activity and stable existence, encoded by an open reading frame (ORF) in a long non-coding RNA. It is the first time that the long non-coding RNA encoding the micropeptide has been found to be significantly related to organ fibrosis and can encode the micropeptide. Synthetic peptides prepared based on the aforementioned OFMP micropeptide show significant inhibitory effects on several key indicators of organ fibrosis, including type I collagen α1 chain gene, α-smooth muscle actin, transforming growth factor β1, and connective tissue growth factor. This indicates that the OFMP micropeptide, the nucleotide sequence (ORF) encoding the micropeptide, and the long non-coding RNA sequence containing the nucleotide sequence have important clinical diagnostic and therapeutic value for organ fibrosis.

In some examples, a tool for, e.g., creating a sub-sternal tunnel in a patient or other use, is described. The tool may include a handle and a tunneling shaft coupled to the handle. The tunneling shaft extends from a proximal end to a distal end, and at least a portion of the tunneling shaft extends in a curved orientation between the first end to the distal end. The distal end of the tunneling shaft includes a cutting tool having a sharp edge. The cutting tool is moveable from a recessed position in which the sharp edge of the cutting tool is recessed into the distal end of the tunneling shaft to a deployed position in which the sharp edge of the cutting tool extends beyond the distal end of the tunneling shaft in the deployed position, e.g., to cut pericardium, scar tissue, and / or connective tissue with the sharp edge.

The invention relates to the technical field of medical materials, in particular to a composition for soft tissue increment and a preparation method thereof, and the composition for soft tissue increment comprises a plasma matrix compressed material and a microvesicle concentrated solution. The composition for soft tissue increment provided by the invention comprises a plasma matrix compressed material and a microvesicle concentrated solution, the plasma matrix compressed material is rich in effective substances such as platelets and immune cells, has a compact three-dimensional fibrous protein network structure, and can provide a required scaffold for soft tissue regeneration, so that the soft tissue regeneration effect is improved. The microvesicle concentrated solution contains a large number of effective biological components such as cell factors and signal molecules, regeneration of local soft tissue can be further regulated and controlled, the microvesicle concentrated solution and the microvesicle concentrated solution have a synergistic effect, the excellent soft tissue regeneration promoting capacity is achieved, a complete autologous source is achieved, connective tissue transplantation surgery is replaced, and the application prospect is wide. The excellent performance is shown in the clinical application of soft tissue regeneration.

This invention belongs to the field of biomedicine and relates to the application of a detection reagent for a marker of mixed connective tissue diseases. This invention discloses... MEF2C Genes can serve as biomarkers for mixed connective tissue disease; they are found in the peripheral blood of patients with mixed connective tissue disease. MEF2C Gene expression levels were significantly higher in the group than in the healthy group. This invention provides a detection reagent for a mixed connective tissue disease marker, comprising an upstream primer with the nucleotide sequence shown in SEQ ID NO.3 and a downstream primer with the nucleotide sequence shown in SEQ ID NO.4, which can detect... MEF2C Gene expression levels, which can then be used to develop products for the early diagnosis of mixed connective tissue diseases.

A joint rotational exercise and stretching tool for strengthening muscles and connective tissues, particularly for shoulder internal and external rotation, with further applicability to the wrist, elbow, and hip. The device includes a mount, torque-generating mechanism, and ergonomic lever arm configured to align with anatomical joint axes. It enables concentric, eccentric, isometric, and passive modes of use. Unlike traditional tools that provide linear resistance or partial-range torque, this invention delivers continuous rotational resistance across the full arc of motion. Configurable mounting and ergonomic adjustments allow use across various joints, limb lengths, and exercise positions. Suitable for rehabilitation, injury prevention, and performance training in clinical, home, or athletic environments.

The invention discloses a multi-modal fusion maternal and child medical image intelligent identification and diagnosis auxiliary system and method, and belongs to the technical field of medical health, and the system comprises a data obtaining module which is used for obtaining a medical image of a related part of a patient, the related part comprises an area corresponding to gland tissue, related processing is carried out on the medical image, and the medical image is obtained; the correlation processing includes distinguishing the medical image into an image corresponding to a gland and an image corresponding to connective tissue. According to the method, by obtaining and distinguishing gland and connective tissue medical images, extracting edge features and monitoring area changes, the lesion site can be accurately judged, the distance change between the blood vessel and the blood vessel group can be quantitatively evaluated, then the lesion development trend is scientifically judged, a comprehensive and objective diagnosis basis is provided for doctors, and the diagnosis efficiency is improved. And the diagnosis accuracy and the clinical decision scientificity are effectively improved.

Embodiments of the instant disclosure relate to an in vitro system for generating 3D skin equivalent, compositions, and methods for modeling and analyzing potential therapeutic treatments of Ehlers-Danlos Syndrome (EDS), including personalized therapies and regimens. In certain embodiments, the in vitro system can be utilized to facilitate diagnosis, drug discovery, investigation of disease mechanisms, and treatment of EDS and other connective tissue diseases. In certain embodiments, compositions, and methods for making and using matrix metalloproteinase 9 (MMP-9) inhibitors are disclosed to treat EDS. In some embodiments, a subject has hypermobility type EDS (hEDS).

The invention relates to an edible composite membrane of water-soluble dietary fiber and collagen as well as preparation and application of the edible composite membrane, and belongs to the technical field of biological materials. Preparing a culture medium from konjac glucomannan and a nitrogen source, and sterilizing; adding edible and medicinal fungus lucid ganoderma into the culture medium for culture and fermentation, and then centrifuging to remove precipitate to obtain hydrolyzed konjac oligosaccharide; after collagen is swelled, the collagen is extracted from tendon or connective tissue of an animal, or the collagen is extracted from animal skin; adding konjac oligosaccharide to obtain a film forming solution; and pouring the film forming liquid into a mold, and drying to obtain the edible composite film of the water-soluble dietary fiber and the collagen. The edible composite film has the advantages of high thermal stability, high antibacterial activity, compact and smooth surface, good moisture resistance and the like. Konjac oligosaccharide is soluble dietary fiber and has the physiological activity of reducing blood sugar and blood fat, preventing cancers and the like, and the edible film synthesized from the konjac oligosaccharide can improve the basic performance defect of collagen and can also endow the film with the health-care effect.

This invention relates to a method for producing extracellular matrix using connective tissue cell culture and to the uses of the produced extracellular matrix. More specifically, it relates to a method for culturing connective tissue cells using a serum-free and heterogeneous culture medium, which can be effectively used to increase the amount of extracellular matrix produced. Furthermore, the extracellular matrix produced by the production method of this invention is derived from human cells and does not contain any heterogeneous components such as fetal bovine serum, making it safe and useful for future development of cell therapy agents, medical supplies, medical devices for tissue treatment, or cosmetic raw materials.

The present invention relates to a method for preparing an extracellular matrix cultured by connective tissue cells and to the use of the prepared extracellular matrix. More specifically, the present invention relates to a method for culturing connective tissue cells using a serum-free and heterogeneous component-free culture medium, which can be effectively utilized in increasing the amount of extracellular matrix production. Moreover, the extracellular matrix prepared by the preparation method of the present invention is an extracellular matrix derived from human cells, and can be safely and effectively used in the development of medical instruments, cosmetic raw materials, or the like for tissue therapy, such as cell therapeutic agents, medical supplies, and the like, without using heterogeneous components such as fetal calf serum.

The application discloses a method for treating premature ejaculation by using high-frequency muscle-bone ultrasonic guiding razor needle to release the connective tissue of the dorsal nerve of penis, and belongs to the technical field of minimally invasive treatment of male sexual dysfunction. The method can accurately distinguish the course, branch and adjacent blood vessel level of the dorsal nerve of penis and mark the safe needle insertion area through real-time imaging of high-frequency muscle-bone ultrasound. A 0.4mm razor needle is used to perform longitudinal push-cut release in the interspace of the dorsal nerve of penis under the whole-process monitoring of ultrasound, so as to release the adhesion of the loose connective tissue under the skin and the high-tension structure. Then, transverse push-cut release is performed in the coronal sulcus area, so as to reduce the local sensory afferent excitability and prolong the ejaculation latency. The application realizes visual operation in the whole process, has small trauma and is controllable and accurate, does not damage the main stem of the nerve and the blood vessel, can stably improve the symptoms of premature ejaculation and is suitable for clinical standardization and popularization.

The application discloses a surgical knife for layered cutting of connective tissue grafts on the palate side of the maxilla, and belongs to the technical field of oral medical instruments. The surgical knife comprises a handle, a connecting rod, and a layered cutting head end arranged at the distal end of the connecting rod. The layered cutting head end comprises a pair of parallel blades, a pair of depth-limiting baffles, and a tissue separation block arranged between the parallel blades. The width and depth of the graft can be accurately set through a width adjustment mechanism and a depth adjustment mechanism. During the cutting process, the tissue separation block can separate the keratinized gingiva on the surface layer from the deep tissue in situ, so that a pure connective tissue graft is obtained at one time, and the surface epithelium and deep adipose gland tissue of the donor area are completely preserved. The application realizes precise, minimally invasive and integrated cutting of connective tissue, simplifies the surgical operation, reduces the technical threshold, reduces the pain of patients, and improves the success rate of transplantation.

1. Name of the product in this design: Medical probe. 2. Purpose of this design: For physical therapy of muscle and connective tissue. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the key design points: 3D diagram of the combined state of Design 1. 5. The rear view of Component 1 of Design 1 is the same as the front view of Component 1 of Design 1, so the rear view of Component 1 of Design 1 is omitted; the right view of Component 1 of Design 1 is the same as the left view of Component 1 of Design 1, so the right view of Component 1 of Design 1 is omitted; the rear view of Component 2 of Design 1 is the same as the front view of Component 2 of Design 1, so the rear view of Component 2 of Design 1 is omitted; the right view of Component 2 of Design 1 is the same as the left view of Component 2 of Design 1, so the right view of Component 2 of Design 1 is omitted; the rear view of Component 1 of Design 2 is the same as the front view of Component 1 of Design 2, so the rear view of Component 1 of Design 2 is omitted; the right view of Component 1 of Design 2 is the same as the left view of Component 1 of Design 2, so the right view of Component 1 of Design 2 is omitted; Component 2 of Design 2 is the same as Component 2 of Design 1, so the rear view of Component 2 of Design 2 is omitted; the rear view of Component 1 of Design 3 is the same as the front view of Component 1 of Design 3, so the rear view of Component 1 of Design 3 is omitted; the right view of Component 1 of Design 3 is the same as the left view of Component 1 of Design 3, so the right view of Component 1 of Design 3 is omitted. 6. Other situations requiring explanation: The combination relationship between Component 1 of Design 1 and Component 2 of Design 1 is unique; the combination relationship between Component 1 of Design 2 and Component 2 of Design 1 is unique; the combination relationship between Component 1 of Design 3 and Component 2 of Design 3 is unique. 7. Design 3 is designated as the basic design.

A system and method for a transportation device that utilizes an alternative biomechanics framework for the human lower body that may be used in any transportation vehicle in conjunction or as an alternative to wheels whereby the bones, muscles, and connective tissue of the lower body function together to produce the mechanics of a single wheel rather than the conjoined pendulums of the leading inverted pendulum model of biomechanics.

The application relates to a method for separating and primary culturing of monopterus albus liver cells. The method comprises the following steps: obtaining monopterus albus liver tissue, perfusing the liver tissue with HBSS buffer solution without calcium and magnesium until blood is completely drained; removing the capsule, blood clots and connective tissue after rinsing, and cutting the liver tissue; sequentially using 0.02% EDTA solution, 0.25% trypsin solution and 50 U / mL collagenase IV working solution to perform three-step digestion treatment on the liver tissue fragments; obtaining a cell suspension by blowing and filtering after the digestion is completed, and then performing gradient centrifugal purification of the cells at rotating speeds of 600 rpm, 250 rpm and 80 rpm in sequence; and finally resuspending the cells in DMEM / F12 culture medium containing 10% FBS and inoculating and culturing the cells. The monopterus albus primary liver cells obtained by the method have the advantages of large quantity, high activity and high purity, and provide a reliable in-vitro model for monopterus albus related research.

The present disclosure provides biomaterials and methods for preventing and minimizing progression of cartilage and / or connective tissue damage. Also provided herein are biomaterials and methods for alleviating and / or reducing the risk for developing arthritis (e.g., osteoarthritis) associated with joint injury and / or joint surgery.

The invention provides a muscle biopsy method and device based on a multi-scale muscle biopsy topology network, and the method comprises the steps: carrying out the multi-class automatic segmentation and recognition of muscle fibers, cell nucleuses, connective tissues and microvessels in a muscle biopsy digital section, abstracting each muscle fiber instance as a network node, and constructing a topology network according to the spatial position of the network node. On the basis, the system not only quantifies multi-dimensional attributes such as subtype, form, texture and nuclear distribution of a single muscle fiber, but also innovatively calculates network-level parameters reflecting the overall state of the tissue microenvironment, including muscle fiber type aggregation factors, fibrosis invasion gradient and capillary support indexes; therefore, the spanning from the isolated form analysis to the spatial topology networked comprehensive evaluation is realized. According to the method, traditional pathology assessment depending on subjective experience is converted into a computable and repeatable quantitative analysis system, the key pathology mode is accurately quantified, the objectivity of muscle pathology diagnosis is improved, and data-driven decision support is provided for clinical and scientific research.

To provide pharmaceutical compositions for treating joint or connective tissue diseases, compositions for cartilage regeneration, or pharmaceutical compositions for treating inflammatory diseases.SOLUTION: Disclosed is a composition for preventing or treating a joint disease or connective tissue disease containing dextran, poloxamer or a mixture thereof as the effective ingredients.EFFECT: The composition of the invention stays in the joint or connective tissue for a long time due to the shock-absorbing effect, coating effect or anti-inflammation effect, and relieves the shock, covers a damaged portion in a specific manner thereto, or reduces inflammation of an adhered portion. Thus, the composition may be effectively used for the treatment of the joint or connective tissue disease, or for the cartilage regeneration.SELECTED DRAWING: Figure 5

Compositions comprising a condensed mesenchymal cell body and a hydrogel are provided. The compositions may further include drugs or growth factors. The condensed mesenchymal cell body may include a connective tissue cell, or even a progenitor cell capable of producing connective tissue extracellular matrices such collagen and glycosaminoglycan. Also provided are methods of treating connective tissue defects, cartilage injury, and cartilage degradation.

This utility model discloses a tissue filtration device, including a centrifuge tube, a first filter element, a second filter element, and a propulsion component. The centrifuge tube has an inner cavity with an opening. The first filter element is installed in the inner cavity and has a first filter chamber. The first filter chamber has a first filter hole and an opening, which are connected to the first filter chamber. Tissue homogenate can pass through the first filter hole, while connective tissue is blocked by the first filter element and remains in the first filter chamber. The second filter element is installed at the bottom of the first filter chamber and has a second filter chamber. The second filter chamber has a second filter hole and an opening, the diameter of which is smaller than that of the first filter hole. The second filter hole and the opening are connected to the second filter chamber, where connective tissue is collected. The propulsion component is located in the first filter chamber and is used to propel the tissue homogenate towards the second filter element. The propulsion component applies pressure to the tissue homogenate. This utility model can reduce the residual rate of connective tissue in tissue homogenate, shorten processing time, and improve filtration efficiency.