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208 results about "Tissue Graft" patented technology
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The transfer of tissue from one anatomic site to another, within the same individual or between individuals, without transfer of the tissue's blood supply.
Graft fixation device
InactiveUS7214232B2Easy to installPrevent exitSuture equipmentsBone implantTissue GraftGraft fixation
A graft fixation device combination. The device is useful for affixing a tissue graft to a bone or other body surface. The fixation device has two implantation members connected by a graft retention member. The retention member optionally has at least one lateral wing member extending therefrom. The implantation members have longitudinal passageways therethrough. The graft fixation device also has an insertion member extending from the distal end of each implantation member, the insertion member having a longitudinal passage having a distal blind wall. The passages of the implantation members and the insertion members are in communication with each other, and may be mounted onto insertion members.
Owner:DEPUY SYNTHES PROD INC
Apparatus and methods for independently conditioning and pre-tensioning a plurality of ligament grafts during joint repair surgery
InactiveUS7118578B2Promote faster adhesionFixationJoint implantsLigamentsTissue GraftSurgical department
Apparatus and methods for conditioning and pre-tensioning soft tissue grafts during joint repair surgery, such as during repair of the anterior cruciate ligament (ACL). The inventive apparatus is advantageously adapted and configured so as to enable a surgeon to independently apply a desired tensile load to individual graft strands or graft bundles of a multi-strand tissue graft. The inventive methods enable each graft strand or bundle to be properly tensioned so as to both “condition” the graft to prevent subsequent stretching, relaxation or elongation following surgery, which can destabilize the joint, and to pre-tension each graft strand or bundle to a predetermined amount so that each contributes to the strength and stability of the joint, thus resulting in a stronger and more durable joint. The tensioning device is advantageously equipped with structure for attachment to a patient's limb during the conditioning and pre-tensioning procedure. It has multiple adjustable tension applicators that can be independently manipulated so as to apply a separate tensile load to one or more ends of a tissue graft strand attached to each adjustable tension applicator.
Owner:HS WEST INVESTMENTS LLC
Tissue press and system
InactiveUS6132472AReduce retentionReduce capacitySuture equipmentsInternal osteosythesisTissue GraftEngineering
A tissue press and method for shaping or compressing a piece of tissue comprises first and second members movable relative to each other. A first forming element of a predetermined shape is selectively engageable on the first member. A second forming element of predetermined shape is selectively engageable on the second member. The first and second forming elements are positionable on opposite sides of the piece of tissue. The first and second members are relatively movable between a first spaced apart condition and a second condition in which the piece of tissue is held between the first and second forming elements. Means are preferably provided for monitoring and controlling the amount of pressure applied to the piece of tissue, in order to maintain the tissue in a viable living condition. Means may also be provided for draining off fluid from compressed tissue, so that the tissue can be implanted in a compressed state and imbibe fluid from the host site. A retainer, which may be expandable, can be used to maintain the tissue graft in a compressed condition.
Owner:BONUTTI 2003 TRUST A THE +1
Protein matrix materials, devices and methods of making and using thereof
InactiveUS7662409B2Enhances strength and durabilityFacilitated releaseBiocidePowder deliveryActive agentProtein materials
The present invention relates to protein matrix materials and devices and the methods of making and using protein matrix materials and devices. More specifically the present invention relates to protein matrix materials and devices that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, encapsulated or coated stent devices, vessels, tubular grafts, vascular grafts, wound healing devices including protein matrix suture material and meshes, skin / bone / tissue grafts, biocompatible electricity conducting matrices, clear protein matrices, protein matrix adhesion prevention barriers, cell scaffolding and other biocompatible protein matrix devices. Furthermore, the present invention relates to protein matrix materials and devices made by forming a film comprising one or more biodegradable protein materials, one or more biocompatible solvents and optionally one or more pharmacologically active agents. The film is then partially dried, rolled or otherwise shaped, and then compressed to form the desired protein matrix device.
Owner:PETVIVO HLDG INC
Placental tissue grafts and improved methods of preparing and using the same
Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
Owner:MIMEDX GROUP
Method and apparatus for use of a self-tapping resorbable screw
A bone attachment apparatus and implantation system. The attachment device provides a screw with channels formed therein for implantation within a bone aperture. The channels are used as a torque transfer surface during implantation, and cooperate with a thread forming tap to enable screw implantation simultaneously with thread formation within the aperture. The tap can be used to form channels within the bone. A staple is coupled to the screw and the bone, utilizing the respective channels formed therein, to prevent rotation therebetween. The screw can also cooperate with the staple to secure a soft tissue graft.
Owner:BIOMET MFG CORP
Protein biomaterials and biocoacervates and methods of making and using thereof
ActiveUS20060073207A1Reduce the amount of solutionFacilitated releaseOrganic active ingredientsCosmetic preparationsActive agentBiopolymer
The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates to protein biocoacervates and biomaterials that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, coated medical devices (e.g. stents, valves . . . ), vessels, tubular grafts, vascular grafts, wound healing devices including protein suture biomaterials and biomeshes, dental plugs and implants, skin / bone / tissue grafts, tissue fillers, protein biomaterial adhesion prevention barriers, cell scaffolding and other biocompatible biocoacervate or biomaterial devices.
Owner:PETVIVO HLDG INC
Decellularized grafts from umbilical cord vessels and process for preparing and using same
InactiveUS20050203636A1Narrow downArtificial cell constructsCell culture supports/coatingTissue GraftCell type
A tissue graft is disclosed that includes a decellularized umbilical vessel having a luminal surface and an ablumenal surface, wherein the decellularized umbilical vessel is prepared by an automated dissection process. The decellularized umbilical vessel has not been substantially cross-linked. In one method of use, the decellularized umbilical vessel is capable of having at least one cell type seeded at least a portion of at least one of the luminal and ablumenal surfaces thereof. A process of preparing the tissue graft, methods of using the tissue graft, and kits which contain the tissue graft are also disclosed.
Owner:THE BOARD OF RGT UNIV OF OKLAHOMA
Placental tissue grafts modified with a cross-linking agent and methods of making and using the same
Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in would healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of chorion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and / or chorion is cross-linked. In another aspect, the grafts are composed of amnion and chorion cross-linked with one another. In a further aspect, the grafts have one or more layers sandwiched between the amnion and chorion membranes. The amnion and / or the chorion are treated with a cross-linking agent prior to the formation of the graft. The presence of the cross-linking agent present on the graft also enhances adhesion to the biological tissue of interest. Also described herein are methods for making and using the tissue grafts.
Owner:MIMEDX GROUP
Placental tissue grafts and improved methods of preparing and using the same
Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
Owner:MIMEDX GROUP +1
Graft prosthesis devices containing renal capsule collagen
The invention provides tissue graft compositions comprising collagen-based extracellular matrices derived from renal capsules of warm-blooded vertebrates. The invention further provides a process of harvesting and purifying a renal capsule to provide an extracellular matrix material having beneficial use as a tissue graft and / or cell growth material.
Owner:COOK BIOTECH
Acellular biological material chemically treated with genipin
InactiveUS6998418B1Low antigenicityLow immunogenicityBiocidePeptide/protein ingredientsGenipinCytotoxicity
A method for promoting autogenous ingrowth of damaged or diseased tissue selected from a group consisting of ligaments, tendons, muscle and cartilage, the method comprising a step of surgically repairing the damaged or diseased tissue by attachment of a tissue graft, wherein the tissue graft is formed from a segment of connective tissue protein after an acellularization process, the segment being crosslinked with genipin, its analog or derivatives. The genipin-fixed acellular tissue provides a microenvironment for tissue regeneration adapted for use as a biological implant device due to its low cytotoxicity.
Owner:GP MEDICAL
Amniotic membrane covering for a tissue surface and devices facilitating fastening of membranes
ActiveUS7494802B2Reduce inflammationPromote wound healingBioreactor/fermenter combinationsBiological substance pretreatmentsBandage contact lensDelivery vehicle
The present invention relates to a biopolymer covering for a tissue surface including, for example, a dressing, a bandage, a drape such as a bandage contact lens, a composition or covering to protect tissue, a covering to prevent adhesions, to exclude bacteria, to inhibit bacterial activity, or to promote healing or growth of tissue. An example of such a composition is an amniotic membrane covering for an ocular surface. Use of a covering for a tissue surface according to the invention eliminates the need for suturing. The invention also includes devices facilitating the fastening of a membrane to a support, culture inserts, compositions, methods, and kits for making and using coverings for a tissue surface and culture inserts. Compositions according to the invention may include cells grown on a membrane or attached to a membrane, and such compositions may be used as scaffolds for tissue engineering or tissue grafts. A method of preparing and using an amniotic membrane covering for a tissue surface as a controlled release drug delivery vehicle is also disclosed.
Owner:TISSUETECH INC
Tissue transplantation method and apparatus
ActiveUS7794449B2Minimize and eliminate needEliminate needInfusion syringesWound drainsTissue GraftMaterial Perforation
The present invention provides for the transplantation of tissue from a donor site in a body to a recipient site. The device includes an outer chamber having an interior volume in which a perforated inner chamber can be placed. During the aspiration of tissue, a vacuum is formed in the interior volume of the outer chamber, to draw tissue from a cannula into the perforated inner chamber. The perforations are sized such that fat is collected within the inner chamber, while fluids and other materials are drawn through the perforations, away from the collected fat. For reinjection, the inner chamber can be removed from the outer chamber, and a sleeve positioned to cover the perforations and thereby form a syringe body that can be interconnected to a needle and plunger for reinjection of the collected fat.
Owner:SHIPPERT ENTERPRISES
Protein biomaterials and biocoacervates and methods of making and using thereof
ActiveUS8153591B2Reduce the amount of solutionFacilitated releaseOrganic active ingredientsCosmetic preparationsActive agentBiopolymer
Owner:PETVIVO HLDG INC
Suspensory graft fixation with adjustable loop length
InactiveUS20120109194A1Reduce loop lengthShorten the lengthSuture equipmentsLigamentsBone tunnelLoop length
A suspensory graft ligament fixation device is shown to be particularly suitable for maximizing the contact between a soft tissue graft and the bone tunnel prepared to receive the graft. The suspensory fixation device has an elongated anchor member adapted to be transversely situated at the exit of the bone tunnel. A loop member is suspended transversely from the anchor member and has a loop length which is adjustable. When a graft ligament is attached to the saddle end of the loop, the length of the loop member may be shortened to pull the graft member into the bone tunnel until it bottoms out at the floor of the bone tunnel.
Owner:LINVATEC
Reinforced tissue graft
A biocompatible tissue graft includes a first layer of a bioremodelable collageneous material, a second layer of biocompatible synthetic or natural remodelable or substantially remodelable material attached to the first layer; and at least one fiber that is stitched in a reinforcing pattern in the first layer and / or second layer to mitigate tearing and / or improve fixation retention of the graft, and substantially maintain the improved properties while one or more of the layers is remodeling.
Owner:THE CLEVELAND CLINIC FOUND
Particulate Tissue Graft with Components of Differing Density and Methods of Making and Using the Same
ActiveUS20110020418A1Rapid responseIncrease influenceBiocidePowder deliveryTissue GraftVolumetric Mass Density
Disclosed are tissue graft compositions made of particles having different densities, methods of making these compositions, and methods of using these compositions for promoting tissue restoration in a patient.
Owner:ACELL INC
Tissue graft materials containing biocompatible agent and methods of making and using same
InactiveUS20080063627A1Function increaseMaintain good propertiesBiocideMammal material medical ingredientsTissue GraftBiomedical engineering
The invention provides implantable tissue graft materials composed of a collagenous tissue scaffold and a biocompatible agent bonded to the tissue scaffold via an activated photoreactive group. The invention further provides methods including steps of obtaining a tissue graft material comprising a collagenous tissue scaffold; contacting the collagenous tissue scaffold with a biocompatible agent composition that includes biocompatible agent and one or more photoreactive groups; and treating the collagenous tissue scaffold and biocompatible agent composition to activate the photoreactive groups and bond the biocompatible agent to the tissue scaffold via one or more activated photoreactive groups. Implantable prostheses formed of the tissue graft material are also contemplated.
Owner:SURMODICS INC
Quadriceps tendon stripper/cutter
InactiveUS20140277020A1Minimally invasiveImprove beauty effectDiagnosticsEndoscopic cutting instrumentsTissue GraftQuadriceps tendon
Instruments and methods that allow for a minimally invasive way to harvest a tissue graft which has been typically done as a full open procedure. The instrument is a hybrid stripper / cutter device provided with both stripping and cutting blades / mechanisms that allow stripping and cutting of the tissue graft with the same hybrid instrument. The present invention also provides a minimally invasive technique for stripping and cutting (resecting) a tissue graft by employing a single, hybrid stripper / cutter instrument. The technique provides a consistently good-quality graft with improved cosmetic results, and is simple and easily reproducible.
Owner:ARTHREX
Bio-polymer and scaffold-sheet method for tissue engineering
ActiveUS20090093565A1Easy to divideAvoid communicationAdditive manufacturing apparatusSurgical adhesivesElastomerPolyester
A method of making a new type of biomaterials, biodegrable crosslinked urethane-containing polyester (CUPE) elastomers and a scaffold-sheet engineering method for tissue engineering applications is provided. CUPEs can be synthesized by forming a linear pre-polymer, which is a polyester, introducing the urethane bonds into polyester using a diisocyanate as a linker, and crosslinking the resulting urethane containing linear polymers to form CUPEs via post-polymerization. This family of polymers, CUPEs, exhibit excellent biocompatibility with desired degradation. Tissue engineering scaffolds made of CUPEs are soft and elastic, and have good mechanical strength. Complex tissue grafts can be constructed by a novel layer-by-layer (LBL) scaffold-sheet engineering design using CUPE sheets. CUPE scaffolds can provide openings for cell to cell communication across scaffold layers and angiogenesis into the depth of the construct. Biomolecules, such as anticoagulants, can be incorporated into the CUPE polymers, increasing their viability as vascular graft scaffolds.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Protein matrix materials, devices and methods of making and using thereof
InactiveUS20100196478A1Enhances strength and durabilityFacilitated releaseAntibacterial agentsBiocideActive agentProtein materials
Owner:PETVIVO HLDG INC
Method for vocal cord reconstruction
A method for surgical repair of damaged or diseased head and neck tissues is described. In one aspect of the invention tissue graft constructs comprising vertebrate submucosa or vertebrate basement membrane materials are used to repair and promote growth of endogenous vocal cord tissue.
Owner:CLARIAN HEALTH PARTNERS
Devices and methods for tissue transplant and regeneration
InactiveUS20070239066A1Promote cell growthIncrease the number ofSurgical needlesVaccination/ovulation diagnosticsIntact tissueMedicine
Devices and methods for transplanting tissue for the purpose of regeneration, for treating a patient having injured myocardial tissue, and / or for improving cardiac function through cell regrowth. More specifically, the devices and methods obviate the need for cellular alteration. The devices comprise a hollow tube with a sharp distal end, a stylet that is disposed and movable within the hollow tube, and a stopping device that constrains movement of the stylet. The methods comprise removing intact tissue from a first region of a mammalian organ and implanting the tissue in a second region of the same organ.
Owner:BETH ISRAEL DEACONESS MEDICAL CENT INC
Implant placement systems, devices, and methods
Described herein is a simplified placement system and method for a tissue graft anchor by which a surgeon may introduce one or more sutures into a hole in a boney tissue, apply tension to the sutures to advance a soft tissue graft to a desired location, and then advance the anchor into the bone while maintaining suture tension and without introducing spin to the suture.
Owner:TENJIN
Decellularized grafts from umbilical cord vessels and process for preparing and using same
Owner:THE BOARD OF RGT UNIV OF OKLAHOMA
Tissue graft scaffold made from cholecyst-derived extracellular matrix
InactiveUS7550152B2Reduced likelihood of inducing inflammatory responseHigh tensile strengthBiocideMammal material medical ingredientsCell-Extracellular MatrixMammalian tissue
Bioengineered tissue graft scaffolds and method for producing such scaffolds are provided. The scaffolds are useful to replace or repair damaged mammalian tissues and organs.
Owner:THE NAT UNIV OF IRELAND GALWAY
Methods and devices for surgical drains with sensors
The present invention is directed to a system and method for postoperative monitoring of the condition of a tissue or organ utilizing sensors that may be embedded in various types of surgical drains. The system is comprised of a probe and a monitoring unit. The probe may include a surgical drain with fluid draining channels housing one or more sensors to measure various parameters of the adjacent tissue. The monitoring unit which controls the sensors of the probe may include a processor to process, record and display the measured parameters. This system may be valuable for monitoring transplanted organs and tissue grafts during the critical postoperative period when most of the clinical complications, such as vascular thrombosis, may occur.
Owner:MANSOUR HEBAH NOSHY +1
Tissue press and system
InactiveUS20010008979A1Reduce retentionReduce capacitySuture equipmentsBone implantTissue GraftBiomedical engineering
A tissue press for shaping or compressing a piece of tissue comprises first and second members movable relative to each other. A first forming element of a predetermined shape is selectively engageable on the first member. A second forming element of predetermined shape is selectively engageable on the second member. The first and second forming elements are positionable on opposite sides of the piece of tissue. The first and second members are relatively movable between a first spaced apart condition and a second condition in which the piece of tissue is held between the first and second forming elements. Means are preferably provided for monitoring and controlling the amount of pressure applied to the piece of tissue, in order to maintain the tissue in a viable living condition. Means may also be provided for draining off fluid from compressed tissue, so that the tissue can be implanted in a compressed state and imbibe fluid from the host site. A retainer, which may be expandable, can be used to maintain the tissue graft in a compressed condition.
Owner:BONUTTI RES +1
Systems, devices and methods for monitoring hemodynamics
Systems, devices and methods for monitoring hemodynamics are described. The systems and methods generally involve directing light toward an area of the body and detecting the resulting scattered light. The scattered light is detected and an electrical signal representative of the scattered light intensity is generated from the detected light. The electrical signal is analyzed by measuring temporal fluctuations of such signals to monitor pathological states over time including hemorrhagic shock, hypoxia, and tissue graft vascularization. Such monitoring can have significant benefits to patients.
Owner:RADIATION MONITORING DEVICES
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