56 results about "Recipient site" patented technology

Provided are procedures and instruments for preparing and transplanting osteochondral allograft plugs to a host bone to repair an articular cartilage defect. An allograft bone plug having a cartilage plate and cancellous bone tissue attached thereto is removed from a donor bone. The allograft plug is further shaped by removing or cutting away cancellous bone tissue to form a cancellous stalk extending from the cartilage plate. The formed cancellous stalk can have any suitable shape including cylindrical, conical, and rectilnear. At the recipient site of the host bone, a cutout is formed corresponding in shape to the allograft plug. The allograft plug is inserted into the cutout such that the cancellous stalk is retained in the host bone and the cartilage plate aligns with the condyle surface of the host bone. Aspects of the invention may also be applicable to preparing and transplanting osteochondral autograft plugs.

The present invention provides skin grafting and devices that comprise a systematic approach to the process of skin grafting, i.e., harvesting, post-excision processing and application of donor skin and pre and post-graft treatment of the recipient site.

An instrument for retrograde cutting of sockets or tunnels in bone for arthroscopic tenodesis. A retrograde cutter is used to form a recipient site socket from the inside out, i.e., using a retrograde technique, with minimal incisions of distal cortices and reduced intraarticular bone fragmentation of tunnel rims. The retrograde cutter is provided with a cutting blade that is configured to engage the shaft of the instrument and to lock onto the shaft.

A tissue processing system includes a series of blades arranged in parallel to form a tissue processor. The blades may be adjusted to create a spaced between each blade in the range of 250-1000 microns. A slicer is included to remove a donor tissue to be processed by the processor. The processor is rotatable 90 degrees so as to create uniform micrografts of tissue for transplanting to a recipient site. An extractor is included to remove tissue particles from the processor after they have been cut into an appropriate size. A cutting block may be provided to ensure uniform thickness of cuts of the donor tissue.

A sample support plate (100) for a variety of possible applications, including MALDI mass spectrometry, is disclosed. A plurality of spatially separated sample recipient sites (101) are arranged on the surface of a substrate. The recipient sites are mutually separated by areas having a different wettability than the recipient sites. They are arranged in a plurality of rows consisting of a plurality of recipient sites whose centers are regularly spaced along a first direction with a predetermined periodicity (D1), the rows being regularly spaced along a second direction perpendicular to the first direction with a predetermined centerline distance (D2). Each recipient site has a maximum lateral dimension that is preferably smaller than the diameter of a beam spot (104) of a desorption laser beam (103). In order to enable unsupervised splitting of bulk liquid samples into droplets at the sample recipient sites, the periodicity along the first direction and the centerline distance along the second direction are chosen such that each recipient sites has a next neighbor at a distance that is less than or equal to three times the minimum lateral dimension of each recipient site. In preferred embodiments, the sample recipient sites are arranged in a checkerboard-type pattern or in rows that are inclined relative to the edges of the sample support plate.

A system for transplanting a bone plug from a donor site to a recipient site extracts the bone plug from the donor site, and then places a bone plug delivery device having a tip which is at least translucent and, preferably, clear over a tube containing the bone plug. The tip is then placed substantially over a pre-formed hole in the recipient site, whereafter the bone plug is forced from the tube, through the transparent tip, and into the pre-formed hole.

A method for expanding human corneal endothelial cells includes: (a) providing an amniotic membrane with or without amniotic cells, wherein the amniotic membrane has an extracellular matrix; (b) placing onto the amniotic membrane, a sheet of endothelial layer, or a cell suspension including human corneal endothelial stem cells; and (c) culturing the corneal endothelial cells on the amniotic membrane for a duration sufficient for the corneal endothelial stem cells to expand to an appropriate area. The invention also relates to a method for creating a surgical graft for a recipient site of a patient using the method for expanding human corneal endothelial cells, and the surgical graft prepared therefrom.

A device for use in cutting plugs of submerged substrate and particularly seagrass plugs for the purpose of transplanting using a corresponding transport receptacle and method. The device utilizes a hollow cutting member with a serrated bottom edge capable of being placed over a targeted area and forced into the submerged substrate, created vacuum pressure in the hollow cutting member, and compressed air injected between the exterior of the hollow cutting member and the submerged substrate to accomplish cutting of a submerged substrate unit. Vacuum pressure in the hollow cutting member is released to transfer the collected unit to the corresponding transport receptacle with a removable bottom. A corresponding method for transplanting a collected seagrass plug is further accomplished by creating a hole at recipient site using the device and removing the transport receptacle's removable bottom to release the plug into the created hole.

A retrograde osteochondral autograft transfer system that ensures that grafted healthy bone is implanted into the recipient site in a retrograde manner as opposed to a conventional anterior manner, so that the grafted healthy bone is flush with the bone surface of the recipient size. The retrograde osteochondral autograft transfer system of the present invention employs two identically-sized harvesters which are aligned with each other for transfer and reversal of a harvested osteochondral core, such that the core can be introduced into the recipient site through a tunnel leading to the recipient site, with an articular surface of the core advanced in a leading position.

The present invention provides for methods and devices suitable for producing a transplantable cellular suspension of living tissue suitable for promoting tissue regeneration in an epithelium-related procedure, as well as compositions produced therefrom. The cellular suspension can include viable and functioning cells at various stages of differentiation, including undifferentiated/progenitor cells and differentiated cells, as well as those in between. In certain embodiments, the cellular suspension can be subjected to a stress to induce a heat shock response therein, or be exposed to an exogenously supplied agent such as heat shock protein or a fragment thereof, hyaluronic acid, platelet-enriched plasma, and/or growth factors. The cellular suspension can be applied directly to a patient's recipient site for in vivo regeneration, or be cultured or seeded to a matrix for in vitro growth/regeneration.

Provided is a technique of manufacturing a scaffold for jaw bone or bone reconstruction, by which a scaffold is fast and accurately manufactured to be placed instantly after treatment and simultaneously a scaffold is manufactured to be stably placed in an irregular recipient site or a wide region such as a tumor. A method of manufacturing a block type scaffold include generating a three-dimensional (3D) image of a scaffold to be placed in a recipient site for bone reconstruction by using a medical image file (DICOM file) of CT image data, dividing the 3D image of the scaffold into a plurality of block images, and manufacturing the scaffold by outputting the 3D image of the scaffold by using a 3D printer, wherein a plurality of 3D objects corresponding to the plurality of block images are output to be separable from one another.

A method of fixating allogeneic bone to an area of deficient bone in the jaws comprising: exposing the area of deficient bone by incising and retracting soft tissue; selecting a drill bit having a diameter corresponding to the area of deficient bone to receive donor bone; contacting the selected drill bit with the exposed deficient bone to form a generally cylindrical seat for receiving the donor bone; selecting a section of donor bone having a generally cylindrical shape and circular cross-section corresponding to said formed seat; fixating the donor bone to the formed seat with at least one screw; and closing the soft tissue to cover the previously exposed deficient bone.