15 results about "Allograft bone" patented technology

The invention belongs to the technical field of cell small molecule compound reprogramming and bone tissue engineering material culture, and discloses a method for inducing fibroblasts to be reprogrammed into osteoblasts. According to the invention, small molecule compounds act on fibroblasts, each small molecule is endowed with characteristics of a set of characteristic gene expression mode, and the small molecules are divided into different modules according to the expression characteristic mode, so that the fibroblasts of the cells are converted into osteogenic differentiation, the osteogenic differentiation effect is enhanced and maintained, and the in-vivo development of the cells is simulated to a great extent; therefore, healthy osteoblasts can be prepared from the skin fibroblasts, cell stress pressure can be resisted, and the prepared cells are free of tumorigenicity, safe and healthy. The osteoblast disclosed by the invention can be applied to preparation of bone materials and medicines for treating bone defects, for example, the osteoblast and a traditional bone material are used for constructing an active bone tissue engineering material, so that the use of allogeneic bones commonly used in clinic at present is avoided, and the occurrence of adverse ethical events is reduced.

The invention discloses precise cutting equipment for allogeneic bone machining, which comprises an ultrasonic osteotome and an allogeneic bone clamping piece, the ultrasonic osteotome comprises a replaceable cutting tool bit, and an ultrasonic vibration generator acting on the cutting tool bit is arranged in the ultrasonic osteotome; a runner pipe is embedded in the upper portion of one side of the ultrasonic osteotome, electrode connectors are arranged at the two ends of the runner pipe respectively, and quantitative liquid expansion metal is contained in the runner pipe. Bone tissue is stably clamped through clamping jaws of the allogeneic bone clamping piece under the action of a pressing disc and a spring piece, a rotating sleeve drives a threaded disc to rotate under pushing of liquid, the extending length of an adjusting fan blade of an adjusting mechanism changes along with changes of centrifugal force, and the clamping force is enhanced when high-density bones are cut in cooperation with changes of the flow speed of the liquid; meanwhile, the bone residues are taken away from the cutting area by the liquid expanding the flowing direction, so that the bone residues are prevented from being sucked away during cutting, the bone residues are prevented from being embedded into bone gaps, the inflammatory reaction risk is reduced, and the bone healing efficiency is improved.

The invention discloses an allogeneic bone composite amniotic membrane particle material and preparation and application thereof, and belongs to the technical field of medical materials.The preparation method comprises the steps that a decellularized amniotic membrane is sequentially subjected to crushing and ultrasonic treatment to obtain amniotic membrane particles, an amniotic membrane particle solution is sprayed to an allogeneic bone subjected to EDC / NHS surface treatment, and the allogeneic bone composite amniotic membrane particle material is obtained. And treating the obtained material under negative pressure to generate amino-carboxyl crosslinking. The amniotic membrane is prepared into amniotic membrane particles, the amniotic membrane particles are uniformly dispersed in the allogeneic bone in combination with a spraying technology, so that the allogeneic bone and the amniotic membrane are organically combined, meanwhile, the amniotic membrane particles are combined with the allogeneic bone subjected to surface treatment through a cross-linking reaction, and the degradation rate of the amniotic membrane is effectively reduced. The allogeneic bone composite amniotic membrane particle material provided by the invention can provide long-term and effective support for osteoporotic bone defect repair, and has a good application prospect.

The present invention relates to the technical field of allogeneic bone sterilization devices, and discloses a sterilization device for producing allogeneic bone implant materials, comprising a sterilization box, a sterilization tank being provided at the top of the sterilization box, a sealing cover being provided at the top of the sterilization box above the sterilization tank, a cavity being provided at the bottom end of the interior of the sterilization box, and a heat-insulating motor being installed on one side of the bottom end of the interior of the cavity. The present invention utilizes the evaporation effect of hot steam in the sterilization tank, cooperates with the steam circulation component A, causes the rotating shaft inside the circulation drum to generate a high speed rotation, thereby forming a downward suction force, thereby causing the hot steam to be sucked into the circulation drum, and cooperates with the action of the steam circulation component B, causing the hot steam to be discharged at high speed along the air guide pipe 2, thereby realizing the circulation flow of the hot steam from outside to inside and from top right to bottom in the sterilization tank, while promoting the flow of hot steam and enabling the hot steam to evenly heat the surface of the ectopic bone along the length direction of the ectopic bone.

This invention discloses a centrifugal drying device for the production of allogeneic bone implant materials, comprising a fixed base, a fixed ring, and a centrifugal drying drum. A support frame is fixedly installed on the side end of the fixed base, and the fixed ring is fixedly installed on the side end of the support frame. The centrifugal drying drum is rotatably mounted on the inner wall of the fixed ring. A drain pipe is fixedly installed through the side end of the fixed base, and a feeding mechanism is provided on the fixed base to facilitate the feeding of materials into the centrifugal drying drum. This invention utilizes a feeding component, a feeding trough, and multiple drying tubes in cooperation. During feeding, the chassis drives each drying tube to rotate, and multiple conical teeth simultaneously drive the feeding component to rotate within the discharge pipe. This ensures that the allogeneic bone implant material is evenly fed into each drying tube, arranging the allogeneic bone implant material neatly within the drying tubes. In case of leakage, the allogeneic bone implant material is separated for subsequent centrifugal drying processing.

The invention relates to the technical field of joint prosthesis processing, and discloses a clamping device for allogeneic bone grinding, which comprises a base sliding rail and two groups of circular ring seats, a rotating seat ring is rotatably mounted on an inner ring of the circular ring seat in a drivable manner, an iris clamping mechanism is arranged on the rotating seat ring, the iris clamping mechanism comprises a rotating ring and a plurality of groups of opening and closing plates, and the rotating ring is used for driving the opening and closing actions of the plurality of groups of opening and closing plates; the multiple sets of positioning chucks jointly position and clamp the allogeneic bone, and flexible chucks used for stably positioning the allogeneic bone are further arranged on the positioning chucks. According to the iris clamping mechanism, synchronous opening and closing of all the chucks are achieved through one-position driving, the operation process is simplified, and efficient synchronous control is achieved; the buffer spring enables each positioning chuck to be independently and elastically adjusted and to be tightly attached to a non-uniform bone shape, local stress concentration is avoided, and the self-adaptive clamping capacity is achieved; and the flexible chuck and the positioning chuck form a double contact surface, so that friction is increased to prevent the aggregate from slipping.

A convenient bone graft injector for artificial or allogeneic bone includes: a body, an injection tube, a locking device, and an injection device. The locking device is used to detachably lock one end of the injection tube to the body. The injection device includes a push rod, an injection elastic member, and a locking and releasing mechanism arranged on the body. The injection elastic member acts between one end of the push rod and the body, and the injection elastic member is configured to provide an elastic push to the push rod, such that the other end of the push rod extends into the end of the injection tube locked to the body and moves towards the other end of the injection tube. The locking and releasing mechanism acts between the push rod and the body, and is configured to lock and release the push rod.

The invention discloses a reduction locking internal fixation device for compression fracture, and relates to the technical field of medical instruments. The device comprises an implantation assembly, a supporting assembly, an adjusting assembly and a locking mechanism, a main body structure of the implantation assembly provides an installation reference, the adjusting assembly drives a threaded rod of the supporting assembly to ascend and descend through meshing of a bevel gear, and a supporting piece is attached to a fracture surface to achieve precise reduction; the locking mechanism fixes the supporting height through gear meshing, and displacement is avoided. The device overcomes the defects that in the prior art, bare-handed reduction depends on experience, fixation easily collapses, and bone grafting resources are in shortage, manual prying and shifting of allogeneic bones are not needed, supporting is even and stable, operation is convenient and fast, the device is suitable for various intra-articular compression fractures such as tibial plateau and proximal humerus, the operation difficulty can be lowered, the treatment effect can be improved, and the complication occurrence rate can be reduced.

The invention provides a small animal allogeneic bone cartilage transplantation instrument. The small animal allogeneic bone cartilage transplantation instrument is characterized by comprising a small animal defect model making device and an allogeneic bone cartilage graft extracting and implanting device which are matched for use, wherein the small animal defect model making device comprises a sharp-bottomed manual bone grinding drill and a flat-bottomed manual bone grinding drill; the sharp-bottomed manual bone grinding drill is used for preliminarily making a small animal defect model; the flat-bottom manual bone grinding drill is used for leveling and shaping the small animal defect model; the allogeneic bone cartilage graft extracting and implanting device comprises a multifunctional transplanter and a multifunctional measurer, the multifunctional transplanter is used for extracting an allogeneic bone cartilage graft; and the multifunctional measurer measures the depth of the small animal defect model and pushes the allogeneic bone cartilage graft extracted from the multifunctional transplanter into the small animal defect model. The device can be used for simply and quickly manufacturing the small animal bone cartilage transplantation model with high quality.

The invention discloses a preparation method of an allogeneic bone shaping material, which comprises the following steps: S1, bone pretreatment to obtain freeze-dried bone powder and demineralized bone powder; s2, bone gelatin extraction; s3, preparing an excipient, wherein the bone gelatin in the step S2 is added into water containing polyvinylpyrrolidone to be swelled; and S4, mixing the freeze-dried bone powder and the demineralized bone powder in the step S1 with the excipient in the step S3 in proportion to obtain the allogeneic bone shaping material. According to the preparation method, polyvinylpyrrolidone is added, the proportion of freeze-dried bone powder to demineralized bone powder in the mixed bone powder is adjusted, the degradation rate of the allogeneic bone powder can be adjusted, and the allogeneic bone powder can be effectively degraded on the basis that good bone induction and bone conduction performance of the allogeneic bone powder is reserved. And the material is endowed with good injectability and plasticity.

The absorbable bone nail comprises an end cover structure at the top, the lower portion of the end cover structure is connected with a main body part which is in a cone frustum shape and gradually contracts from top to bottom, the bottom of the main body part is connected with a cylindrical extension section, and the tail end of the extension section is connected with a conical end part. The diameter of the upper bottom of the cone-frustum-shaped main body part is the same as that of the end cover structure; the diameter of the bottom surface of the cone-shaped end part is the same as that of the extension section; wherein the end cover structure, the main body part, the extension section and the end part are coaxially arranged and adopt an integrally formed structure made of an allogeneic bone; the cone-frustum-shaped main body part is wide in upper part and narrow in lower part, is consistent with the diameter of the end cover, is gradually attached to a bone tissue during implantation, the contact area is gradually increased, the main body part is fully embedded when the bottom of the end cover is attached to the surface of an alveolar bone, the resistance is suddenly increased, and a doctor is helped to accurately judge the depth. The end cover and the main body part are equal to be coaxial and are in a symmetrical and regular shape, inclination can be prevented when the device is implanted along the preset axis, observation is facilitated, and accuracy is improved. The allogeneic bone is of an integrated structure, and the physical strength, the biocompatibility and the absorbability are all considered. The bone material can be absorbed by a human body, and can induce osteoblasts to form new bones on the premise of ensuring a supporting effect, so that fusion substitution is realized. And slow absorption is realized in an induced osteogenesis process, so that secondary operation taking-out is avoided, and reabsorption and reconstruction of soft and hard tissues caused by secondary operation are prevented.

The invention provides a regenerative medical beauty material and a preparation method thereof.The regenerative medical beauty material is prepared by compounding allogeneic bone microspheres subjected to surface treatment and hyaluronic acid, and the surface treatment comprises the following steps that allogeneic bones are selected, cleaned, disinfected, degreased and decalcified to remove impurities; the allogeneic bone is crushed, the bone microspheres are prepared, the bone microspheres are subjected to surface treatment by adopting a bioactive molecule coating, and gaps of the bone microspheres are filled with an absorbable high polymer material after the allogeneic bone microspheres are subjected to surface treatment, so that the biocompatibility and the osteoinductivity are improved, and the immunological rejection risk of a human body on the material is reduced; the regenerated medical beauty material is safer and more reliable, and the use crowd is wider; the hyaluronic acid has good biocompatibility, and after the hyaluronic acid is compounded with the treated allogeneic bone microspheres, the biocompatibility of the whole material is further enhanced, and the occurrence probability of adverse reactions is reduced.

The utility model belongs to the technical field of allogeneic bones, and particularly relates to a bone sawing machine for allogeneic bone production, which comprises a base, a sealing component is arranged at the top end of the outer side of the base, a top plate is fixedly connected to the inner side of the top end of the base, and the top end of the base is slidably connected with first sliding blocks which are opposite left and right. The right side of the inner side of the first sliding block is fixedly connected with a first motor, the front end of the inner side of the first sliding block is fixedly connected with vertically opposite sliding rods, the output end of the first motor is fixedly connected with a threaded rod, the outer side of the middle end of the threaded rod is in threaded connection with a threaded sleeve, and the inner side of the threaded sleeve is fixedly connected with a fixing clamp. The utility model provides a bone sawing machine for allogeneic bone production, which is used for simultaneously cooling allogeneic bone and a saw blade, so that the quality of allogeneic bone tissue can be effectively protected, denaturation, damage or scorching caused by overheating can be prevented, and the biological activity and the mechanical property of the allogeneic bone tissue can be kept.

The present invention relates to the technical field of medical devices, and in particular to a special retaining nail assembly for alveolar bone augmentation, comprising a retaining rod, a threaded portion being provided on the autologous alveolar bone contacting side of the retaining rod; a first retaining piece being provided on the side of the retaining rod away from the threaded portion; an umbrella-shaped connecting portion being provided with a hollow slot body, the extension direction of the slot body being consistent with the axial direction of the retaining rod; a partition being provided perpendicularly to the extension direction of the slot body, the partition body dividing the slot body into a first groove and a second groove; the first retaining piece being matched with the first groove; a matching nail being provided, the matching nail comprising a connected cap body portion and a second retaining piece; the second retaining piece being matched with the second groove. The present invention is used to fix autologous bone blocks and allogeneic bone blocks, and can also be used to stabilize artificial bone powder, so as to solve the problem that the prior art cannot effectively maintain a stable bone grafting space.

The utility model relates to a kind of allogeneic bone repair material polishing device. Including installation base, swing support, horizontal shift subassembly one and horizontal shift subassembly two are set in the top of installation base;Lifting swing arm is pivotally connected on swing support, lifting drive assembly is set between lifting swing arm and swing support;Angle swing arm structure is pivotally connected between angle swing arm structure and lifting swing arm between the outer end of lifting swing arm, swing drive cylinder is pivotally connected;Adjustable mounting seat structure is installed in the outer end of angle swing arm structure, polishing wheel is rotatably connected in the outer end of adjustable mounting seat structure;It further includes polishing drive assembly;It further includes operation table and dust hood installed on installation base, dust hood is connected with fan by gas pipeline.The utility model can automatically move up and down, left and right and before and after to the polishing wheel of rotation, and then it is convenient to polish and trim the local part of allogeneic bone, and operation process is simple and convenient.