The invention provides a cobalt-chromium alloy artery stent with full-biodegradation medicine coating; the full-biodegradation coating of the stent has good stent flexibility, pathological change permeability and radial bearing force; the invention further provides a preparation method of the stent; multi-level coating applying technology, metallic support surface inert gas processing process and the like are adopted, the firmness of the stent surface coating, the toughness and tensile strength thereof are greatly improved, thereby being beneficial to keeping the integrity of the coating; in addition, the invention provides a cobalt-chromium alloy artery stent with full-biodegradation medicine coating, which is prepared by radial grading squeezing process, the damage of the coating can be avoided to the greatest extent, the retention force between the stent and a conveying system is greatly improved, the possibility that the stent is migrated in the conveying process is avoided, the clinical using risk is reduced, and the problems of coronary artery stenosis and restenosis are effectively solved.