85 results about "Scaffold material" patented technology

A system and method for producing an integrated optical assembly, which can include providing a functionalized scaffold material; and forming an optical assembly including at least two optical components within the scaffold material, the forming of the optical assembly including: lithographically patterning a first optical component within the scaffold material; and lithographically patterning a second optical component within the scaffold material aligned with the first optical component.

The invention relates to the technical field of biological ceramic materials, in particular to a zirconium oxide bone repair scaffold material with a porous interconnection structure and a preparation method of the zirconium oxide bone repair scaffold material. The invention aims to solve the problems of poor mechanical property and fragile interconnection structure of the existing stent under high porosity. The core preparation process comprises the following steps of: performing acetone steam annealing and pre-fusion on a double-particle-size microsphere template to form a stable interconnection window prototype; then, a continuous hole wall main body is constructed through vacuum impregnation of high-viscosity zirconium oxide slurry, and then secondary positioning reinforcement is conducted on the interconnected neck parts through low-viscosity nano zirconium oxide sol; finally, diluted bioactive glass sol is introduced to endow the surface with biological activity, and a final product is obtained through temperature-controlled degreasing and sintering. According to the method, the pore connectivity, the mechanical strength and the biological activity of the scaffold are synergistically optimized through template pre-fusion and partition sequential processes, and the method is suitable for repairing load-bearing bone defects.

The invention discloses a multi-parameter online monitoring system for aging failure of an insulating scaffold and a preparation method of the multi-parameter online monitoring system. The monitoring system comprises the insulating scaffold; the monitoring sensor is arranged on the insulating scaffold and is used for acquiring various state parameters of the insulating scaffold; the communication module is connected with the monitoring sensor and is used for transmitting the various state parameters; the on-line monitoring all-in-one machine is connected with the communication module and is used for carrying out data acquisition and comprehensive processing analysis on the signal data of the various state parameters so as to monitor the state of the insulating scaffold in real time and evaluate the aging failure risk of the insulating scaffold; the system can monitor the operation state of the scaffold in a multi-dimensional and real-time manner, and comprehensively analyzes the change trend of the parameters, so that the aging process and failure risk of the scaffold material can be more accurately judged, the abnormality can be timely found, the early warning can be performed in advance, and the occurrence of safety accidents can be prevented.

The invention relates to a mycelium biological symbiotic scaffold material as well as a preparation method and application thereof. The mycelium biological symbiotic scaffold material comprises a biological symbiotic scaffold matrix and mycelia uniformly growing on the surface of the biological symbiotic scaffold matrix, the mycelium has a three-dimensional network porous structure. The mycelium biological symbiotic scaffold material provided by the invention is a novel bone repair biological material with a multilevel structure and biological activity, and a new strategy is provided for tissue regeneration.

The present application provides a kind of block cell culture meat and its preparation method.The present application meets the demand of seed cell large-scale preparation of block cell culture meat by suspension cell scale culture, and realizes the adhesion, proliferation and integration of seed cell on edible scaffold material by specific culture medium induction of suspension cell adhering to wall.The method can be in stirred tank cell bioreactor by sterile scaffold material and cooperate with specific induction culture solution and stirring process, so that the adhesion rate of cell and scaffold material reaches 96.8%.The method uses suspension cell as seed cell, and combines corresponding process and culture medium, effectively solves the problems of seed cell difficult to be large-scale prepared and difficult to be effectively integrated with scaffold material in the culture process of block cell culture meat, and provides scalable scheme for industrialized production of block cell culture meat.

This invention provides a scaffold-free construction method for installing exterior walls of high-rise buildings, belonging to the field of scaffold-free installation technology. This invention utilizes I-beams, limiting devices, steel pipes, fall arrestors, guide devices, and fixing devices. First, the I-beams are installed on a floor platform. Limiting devices are then installed on the I-beams, providing bottom support and limiting for individual steel pipes. Moving the limiting devices causes the steel pipes to slide along the I-beams to a pre-installation position and then locks them in place, thus fixing the fall arrestor to the floor wall. This invention allows for flexible adjustment of the bottom position of the steel pipes through the sliding limiting devices. Combined with the vertical fixing and climbing structure of the guide devices and fall arrestors, the construction platform for high-rise building exterior walls can be erected layer by layer upwards without the need for full scaffolding from the ground. This significantly reduces scaffolding material consumption and the workload of high-altitude erection. The construction platform can rise synchronously with the work surface, ensuring the continuity and efficiency of exterior wall construction.

To provide a resin film formed of a scaffold material for cell culture, the resin film enabling excellent fixation of cells after seeding and thus contributing to an increase in the cell proliferation rate.SOLUTION: A resin film is formed of a scaffold material for cell culture, wherein the scaffold material for cell culture comprises a synthetic resin with a polyvinyl acetal skeleton; the resin film has a phase-separation structure containing at least a first phase and a second phase; and the ratio of the surface area of one of the first and second phases to the total surface area is 0.01-0.95 inclusive.SELECTED DRAWING: Figure 1

To provide a scaffolding material for cell culture that has excellent transparency and can be used in scaffold-type cell culture, particularly a scaffolding material for cell culture that can form a scaffolding material with a hydrogel pattern using a simple method by exposure and development.SOLUTION: Provided is a scaffolding material for cell culture containing a fibrous cellulose with an average fiber width of 100 nm or less, and a negative radiation-sensitive component containing a polymerizable compound and a polymerization initiator, the content of the negative radiation-sensitive component being 20 to 200 pts.mass based on 100 pts.mass of the fibrous cellulose, the negative radiation-sensitive component being a component that is soluble in at least one selected from water, alcohol, and a mixed solvent thereof.SELECTED DRAWING: None

The utility model discloses a general supporting structure for a post-cast strip. The general supporting structure comprises a lifting single prop, lifting supporting rods are arranged in the steel pipes in a sliding and penetrating mode, sleeves arranged on the corresponding lifting supporting rods and the telescopic ends of the lifting single supporting columns in a sleeving mode are fixed to the supporting top plate, locking screws are connected to the sleeves in a penetrating and threaded mode, and the ends of the locking screws abut against the corresponding lifting supporting rods and the telescopic ends of the lifting single supporting columns. The lifting single supporting columns and the steel pipes are connected through connecting frames. The supporting structure has the advantages that during pouring construction of the post-cast strip, a scaffold is built in a construction area, and the supporting structures are erected on the two sides of the post-cast strip at intervals; when post-cast strip construction is completed and concrete design strength is achieved, the scaffold can be dismantled, the supporting structure serves as an independent support to continue to support the two sides of the post-cast strip within the driving route range, and therefore the dismantled scaffold material can be repeatedly used for other construction areas, turnover and reutilization of the material are achieved, and the construction efficiency is improved. The construction cost is reduced.

The application belongs to the technical field of bone tissue engineering, and particularly relates to a recombinant collagen-chitosan-PEG-hydroxyapatite bone repair scaffold material, a preparation method and application. The bone repair scaffold material is formed into a one-way ordered three-dimensional scaffold by a directional freezing method through recombinant collagen, chitosan and PEG. Nano-hydroxyapatite is uniformly deposited in the inside and surface through a special mineralization process. The prepared material has a very good bionic natural bone structure and composition, a good reticular structure and mechanical strength, good biocompatibility and cell activity, a significant repair effect on critical size bone defects, a good osteogenic induction effect and bone conductivity. The bone repair scaffold material provides a new potential treatment method for severe bone defects, and has a wide application in the fields of artificial bone, artificial cartilage, biological scaffolds and the like.

The disclosure relates to a scaffold graft material, or platelet rich plasma (PRP) graft, and method of production thereof, for tissue repair and / or support (e.g. reinforcement). In one particular application, the scaffold material is used for treating pelvic organ prolapse (POP).

The invention relates to an extracellular vesicle-frozen gel scaffold as well as an integrated preparation method and application thereof, and belongs to the technical field of biotechnology and tissue engineering materials. The problems that in the prior art, extracellular vesicles are prone to being damaged by low temperature in the frozen gel preparation process, a traditional cryoprotectant is not compatible with a stent process, and burst release and action time is short in a vesicle physical adsorption method are solved. The method comprises the following steps: mixing extracellular vesicles with a trehalose solution, and standing to obtain a vesicle-trehalose mixed solution; mixing with the support material prepolymer solution, and adding a photoinitiator to form a composite precursor solution; freezing the solution, and performing cross-linking solidification to form a three-dimensional porous gel scaffold; and unfreezing and washing to obtain the stent. The trehalose is introduced as a cryoprotectant, vesicle activity protection and stent structure forming are synchronously achieved in low-temperature forming, and the prepared stent can achieve controllable slow release of vesicles and has good application prospects in the field of tissue repair and regeneration.

The invention relates to a decellularized scaffold composite dynamic hydrogel material which comprises an interpenetrating network structure formed by a decellularized scaffold and dynamic cross-linked hydrogel, and the dynamic cross-linked hydrogel is formed by cross-linking initiated by hydrophobic group modified hyaluronic acid and cross-linked group modified cyclodextrin. The dynamic crosslinking hydrogel further comprises hydrogel formed by crosslinking initiated by gelatin or crosslinking group modified glycosaminoglycan. The invention also relates to a preparation method of the composite material. The preparation method comprises the following steps: preparing a pre-gel solution from the hydrophobic group modified hyaluronic acid, the crosslinking group modified cyclodextrin and the crosslinking initiator; and dripping the pre-gel solution on the surface of the decellularized scaffold, and initiating cross-linking to obtain the hydrogel-decellularized scaffold composite material. The decellularized scaffold composite dynamic hydrogel material satisfies three characteristics of mechanical properties, biological adaptation degradability and structural dynamic heterogeneity, is a scaffold material better imitating an extracellular matrix, and has an application prospect in the field of tissue repair.

The utility model belongs to the field of trolley, especially a bridge shed integrated inner and outer mould trolley, aim at the low efficiency of the existing bridge shed construction: template needs repeatedly dismounting, transport, the erection and removal process of full hall scaffold can easily cause safety accidents; Scaffold material and labor cost are high, the problem that field assembly precision is difficult to control, present the following scheme, it includes inner mould trolley and outer mould trolley, the inner mould trolley includes inner frame stand, the lateral work platform is fixedly installed to the side of inner frame stand, a plurality of inner frame stand are fixedly connected through longitudinal scissors and longitudinal connecting beam between the side, in the utility model, inner mould trolley and outer mould trolley work cooperatively, realize the full process automation of bridge shed construction, through the mechanism such as vertical cylinder in stand, side mould upper translation cylinder, realize the quick stripping and translation of template, common rail walking mechanism: inner mould trolley and outer mould trolley common rail design, outer mould trolley can demould in advance and walk independently, avoid construction conflict.

This cell culture kit (100) is provided with a culture vessel (110) and a culture sheet (150). The culture sheet (150) is a scaffold material for culturing cells. The culture container (110) has therein an accommodation space, in which the culture sheet (150) is accommodated, and includes an opening that communicates with the accommodation space. The culture container (110) includes a bottom part (112) on which the culture sheet is placed, and a side wall part (113) extending upward from the bottom part (112). The culture sheet (150) has a shape and size such that when placed on the bottom part (112) a gap is formed between the outer edge part of the culture sheet (150) and the side wall part (113).

This invention provides a method for constructing ultra-high-rise buildings with ultra-long span simply supported floor slabs without support, comprising: hoisting and connecting structural steel columns; hoisting structural steel beams and connecting them to the corbels of the structural steel columns; laying floor slabs; welding studs to the top of the structural steel beams to fix the galvanized bottom formwork of the floor slabs; installing lower reinforcing bars; installing additional lower reinforcing bars on the floor slabs at the breaks or perpendicular intersections with the structural steel beams; installing upper reinforcing bars; installing additional upper reinforcing bars on the floor slabs at the breaks or perpendicular intersections with the structural steel beams; and pouring concrete. This invention eliminates the need for traditional full-span scaffolding support, enabling the construction of reinforced concrete for simply supported floor slabs exceeding the maximum unsupported span at high altitudes. It shortens the construction period, saves on scaffolding material usage and erection costs, avoids instability in ultra-high support scaffolding, ensures safety during high-altitude operations, fully utilizes the original design's upper and lower chord reinforcing bars and additional upper and lower reinforcing bars, requires no additional construction materials, and is environmentally friendly.

This invention discloses a method for preparing and applying a 3D-printed strong and tough silk fibroin scaffold material. The method includes: incubating silk fibroin fibers in an aqueous lithium bromide solution; modifying with glycidyl methacrylate followed by freeze-drying; obtaining a bio-ink by dissolving in an aqueous photoinitiator solution; obtaining an intermediate solution by dissolving a calcium salt in a methacryloyl phosphate compound; obtaining a photocurable bio-ink by dissolving the intermediate solution in the bio-ink; and photocuring and printing in a 3D printer to obtain the 3D-printed strong and tough silk fibroin scaffold material. This method offers advantages such as good formability, flowability compatible with 3D printers, suitability for various 3D printing modes, and rapid photocuring performance. The prepared scaffold exhibits good biocompatibility, and the printed gel material shows better mechanical properties and stability compared to SilMA, with a slower degradation rate, enabling the scaffold to be widely used in multiple fields such as bone tissue engineering.

The present disclosure is directed to scaffold materials patterned with cell adhesion targets that permit the attachment and growth of predetermined cell types onto the scaffold. By selecting specific ligands that are patterned on the scaffold, particular cell types, including those engineered for this specific purpose, will attach and proliferate to create designed tissues and organs.

This invention relates to the field of bioceramic materials technology, specifically to a porous interconnected zirconia bone repair scaffold material and its preparation method. This invention aims to address the problems of poor mechanical properties and fragile interconnected structures in existing scaffolds under high porosity. The core preparation process includes: using a dual-size microsphere template, pre-fusion via acetone vapor annealing to form a stable interconnected window prototype; subsequently, constructing a continuous pore wall body by vacuum impregnation with high-viscosity zirconia slurry; then, using low-viscosity nano-zirconia sol for secondary positioning and reinforcement of the interconnected necks; finally, introducing diluted bioactive glass sol to impart surface bioactivity, followed by temperature-controlled degreasing and sintering to obtain the final product. This method, through template pre-fusion and a zoned sequential process, synergistically optimizes the scaffold's pore connectivity, mechanical strength, and bioactivity, making it suitable for the repair of weight-bearing bone defects.

To provide a novel method for producing induced pluripotent stem cells (iPS cells) employing a novel scaffold material that can reduce problems associated with conventional microcarriers, and a method for producing differentiated cells using the iPS cells obtained by the production method.SOLUTION: Somatic cells are brought into contact with reprogramming factors, and induced pluripotent stem cells are established in the presence of a sheet-like piece having a surface containing a polymer material as at least one principal surface.SELECTED DRAWING: Figure 1

The invention discloses a degradable macroporous composite tissue engineering scaffold, a structural performance regulation and control method and application, and belongs to the technical field of biomedical materials. Induced phase separation is realized through design of gel molecules and a solvent, so that a macroporous structure is formed; the pore structure is adjusted by controlling the proportion of the polyvinyl alcohol aqueous solution, the glycerol and the hydrophilic degradable biomacromolecule aqueous solution; the mechanical property of the stent is regulated and controlled by adding the degradable inorganic micro-nano particles; meanwhile, a pore structure and a scaffold material with spatial heterogeneity in mechanical property are constructed through hot melt interface integration. The problems that an existing tissue engineering scaffold is insufficient in controllability of a pore structure and mechanical properties and the like are solved, and the degradable macroporous composite tissue engineering scaffold material is suitable for being used as a degradable macroporous composite tissue engineering scaffold material for promoting collaborative injury repair of soft and hard tissues such as osteochondral tissues, muscular bones and tendon bones.

This invention relates to the field of biomedical materials technology, providing a heparinized dual-growth factor recellularized adipose tissue decellularized scaffold material, its preparation method, and its applications. The preparation method includes: decellularizing adipose tissue to obtain adipose tissue decellularized scaffold; heparinizing the scaffold to obtain a heparinized adipose tissue decellularized scaffold; loading hepatocyte growth factor and vascular endothelial cell growth factor onto the scaffold to obtain a heparinized dual-growth factor adipose tissue decellularized scaffold; seeding induced pluripotent stem cell-derived hepatocytes onto the scaffold, and culturing to obtain a heparinized dual-growth factor recellularized adipose tissue decellularized scaffold (RAT). This invention uses rat inguinal adipose tissue to prepare RAT material, which is low-cost, readily available, has a simple preparation process, and is easy to scale up. The RAT material of this invention can achieve liver tissue damage repair and hepatocyte regeneration, providing a new treatment strategy for acute liver failure.

The present invention relates to: a scaffold material comprising cellulose nanofibers (CNF) into which an ionic functional group has been introduced; a cell culture substrate having the scaffold material on the surface thereof; and a method for culturing cells such as stem cells using the scaffold material.

The present application relates to the field of biomimetic mineralization and tissue engineering scaffold materials, and particularly relates to a kind of biomimetic mineralization silk fibroin scaffold material and its preparation method and application.The preparation method comprises the following steps:1) silk fibroin is induced self-assembly, and silk fibroin fiber matrix is obtained;2) the silk fibroin fiber obtained in step 1) is crosslinked, and crosslinked silk fibroin fiber mineralization matrix is obtained;3) the crosslinked silk fibroin fiber mineralization matrix obtained in step 2) is mineralized in mineralization solution, and biomimetic mineralization silk fibroin scaffold material is obtained.The biomimetic mineralization silk fibroin scaffold material prepared by the preparation method is applied to bone tissue repair.In the present application, the mineralization mode in silk fibroin fiber more highly simulates the mineralization form of natural bone tissue, and the similar surface chemical properties and nano-scale structure characteristics of natural bone are reproduced.

Silicon-carbon composite materials and related processes that overcome the challenges for providing amorphous nano-sized silicon entrained within porous carbon. Agglomerated porous carbon is used during a composite creation process.

The present invention relates to a liquid, positively charged, responsive self- assembling peptide, a liquid scaffold material formed from the self-assembling peptide, and applications of the liquid scaffold material.

The present application provides a scaffold material for cell culture, which is excellent in cell adhesion. The scaffold material for cell culture of the present application contains a peptide-containing polyvinyl alcohol derivative having a polyvinyl alcohol derivative portion and a peptide portion, the peptide portion having a cyclic peptide backbone.

The invention relates to the field of high-performance composite materials, in particular to an embryo cryopreservation cell carrier scaffold material and a preparation method of the embryo cryopreservation cell carrier scaffold material. The total amount is 100%: 50.0 to 65.0 weight percent of gelatin, 20.0 to 35.0 weight percent of silk fibroin, 5.0 to 12.0 weight percent of sodium hyaluronate, 3.0 to 8.0 weight percent of chitosan, 0.1 to 2.0 weight percent of RGD polypeptide and 0.5 to 3.0 weight percent of anti-ice crystal forming polypeptide AFP III, the gelatin, hyaluronic acid and silk fibroin ternary composite system simulates biochemical components and physical characteristics of an endometrial extracellular matrix, provides similar in-vivo microenvironment support for embryos, and is beneficial to maintaining embryo activity.

Provided is a resin film formed of a cell culture scaffold material, which has excellent fixation of cells after seeding and is capable of enhancing proliferation rate of cells. A resin film formed of a cell culture scaffold material, in which the cell culture scaffold material contains a synthetic resin, and the resin film has a phase-separated structure including at least a first phase and a second phase, and a ratio of the surface area of one of the first phase and the second phase to the entire surface is 0.01 or more and 0.95 or less.