Construction method of anticoagulant artificial blood vessel scaffold material

A stent material and artificial blood vessel technology, which is applied in the construction field of anticoagulant artificial vascular stent materials, can solve the problems affecting the persistence of NO release, the fast release rate of NO, and the phenomenon of burst release, so as to improve the phenomenon of catalytic NO burst release , overall performance optimization, the effect of inducing and promoting angiogenesis
CN102961783AInactive Publication Date: 2013-03-13NANKAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANKAI UNIV
Publication Date
2013-03-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a construction method of an anticoagulant artificial blood vessel scaffold material. The method includes: taking a rotating stainless steel pipe as a receiver, employing an electrospinning technology to prepare an organic macromolecular polymer, a mixture of a Cu2<+> complex catalyst and the organic macromolecular polymer, and the organic macromolecular polymer successively into a three-layer structured superfine fiber porous tubular scaffold material; and regulating the types and proportion of the Cu2<+> complex catalyst and the organic macromolecular polymer, as well as the electrospinning time of a three-layer electrospinning solution so as to control the release rate of NO. With a three-layer structure, the blood vessel scaffold material formed by the invention not only realizes loading of the Cu2<+> organic complex catalyst, but also improves the phenomenon of NO burst release catalyzed by an ordinary hybrid electrospun structure scaffold material, improves the loading stability of the Cu2<+> complex catalyst, and can leave the biological signal molecule NO to play a better role in inhibiting platelet adhesion, resisting platelet activation and inhibiting smooth muscle cell proliferation so as to improve its anticoagulant property.
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Description

Technical field:

[0001] The invention relates to a method for modifying the surface of a tissue engineering vascular stent material, in particular to a method for constructing an anticoagulant artificial vascular stent material. Background technique:

[0002] There is a great demand for small-caliber blood vessels clinically, but the current small-caliber artificial blood vessels have a high rate of restenosis after implantation in the body. In order to clinically reduce the harm caused by thrombosis, anticoagulants are often used in medicine. However, long-term use of exogenous anticoagulants also has side effects, especially increasing the possibility of bleeding.

[0003] Endothelial cells are natural regulators of blood vessel stability. Endothelial cells play an important role in antithrombosis, inhibition of platelet aggregation, and secretion of vasoactive factors. Molecules with antithrombotic, antiplatelet aggregation properties in endothelial cells include nitric...

Claims

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