289results about How to "Good osteoinductivity" patented technology

An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier. The osteoinductive composition is prepared by providing demineralized bone, extracting osteoinductive factors from the demineralized bone, and adding the extracted osteoinductive factors to a carrier. Further additives such as bioactive agents may be added to the osteoinductive composition. The carrier and osteoinductive factors may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, can induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. Also, in some embodiments, the osteoinductive composition can be used as a delivery device to administer bioactive agents.

A demineralized bone putty composition comprises: (1) demineralized bone matrix (DBM); and (2) a lipid fraction selected from the group consisting of lecithin and a mixture of lecithin and triglycerides containing unsaturated fatty acids. The putty composition is moldable, biocompatible, slowly resorbable, and soluble in tissue fluids, and non-extrudable. The composition delivers a biologically active product to animals and humans that will enhance bone formation at sites where bone is lost, deficient, or present in suboptimal amounts. The composition can further comprise calcium, an antioxidant such as Vitamin E or Vitamin C, or a hydrophilic polymer such as methylcellulose or hydroxypropyl methylcellulose.

The present invention incorporates new materials for bone regeneration, methods for their manufacture, and application in traumatology surgery, maxillofacial surgery, dental surgery, orthognatic surgery, endodontics, ophthalmology, neurosurgery and / or osteoporotic processes, and other indications where bone regeneration is required. In particular, the present invention incorporates synthetic materials with a 20% to a 95%, preferably between 40% and 90% in mass of monetite [Ca1-XMXHPO4, where 0≦x≦0.05, and where M can be a divalent metallic ion], and which in their final composition incorporate between 5% and 80%, preferably between 0% and 60%, in mass of bioactive calcium compounds chosen from calcium phosphates and between 5% and 80% in total mass of bioactive silicon compounds chosen from calcium silicates and / or bioactive silica glasses and gels.

The present invention provides methods of improving the osteogenic and / or chondrogenic activity of a bone matrix, e.g., a dermineralized bone matrix (DBM), by exposing the bone matrix to one or more treatments or conditions. In preferred embodiments the bone matrix is derived from human bone. The treatment or condition may alter the structure of the bone matrix and / or cleave one or more specific proteins. Cleavage may generate peptides or protein fragments that have osteoinductive, osteogenic, or chondrogenic activity. Preferred treatments include collagenase and various other proteases. The invention further provides improved bone and cartilage matrix compositions that have been prepared according to the inventive methods and methods of treatment using the compositions. The invention further provides methods of preparing, testing, and using the improved bone matrix compositions. On a assay comprises exposing relatively undifferentiated mesenchymal cells to a bone matrix composition and measuring expression of a marker characteristic of osteoblast or chondrocyte lineage(s). Increased expression of the marker relative to the level of the marker in cells that have been exposed to a control matrix (e.g., an inactivated or untreated matrix) indicates that the treatment or condition increased the osteogenic and / or chondrogenic activity of the bone matrix. Suitable cells include C2C12 cells. A suitable marker is alkaline phosphatase. The inventive methods increase the osteogenic and / or chondrogenic activity of human DBM when tested using this assay system.

The invention relates to a bone repair composite material based on an acellular biological tissue matrix material and a preparation method of the bone repair composite material. According to the bone repair composite material disclosed by the invention, a micro-fibrotic animal tissue acellular matrix material is taken as an organic component, and a calcium salt biological ceramic material or other inorganic bioglass is taken as an inorganic component. According to the bone repair composite material prepared by the method disclosed by the invention, additional physical crosslinking or chemical crosslinking is not needed, and the bone repair composite material has a complete three-dimensional porous net structure; the protein component in the biological tissue matrix material has the natural triplex structure; the bone repair composite material has the excellent biocompatibility, the complete biodegradability, the excellent osteoconduction, as well as the excellent osteoinductivity and the excellent osteogenesis, also has certain mechanical strength and shape memory function, and can be used as a bone filling material with bioactivity or a repair material for large-area bone defect.