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Polydopamine-modified halloysite nanotube / polylactic acid composite material and preparation and application thereof

A technology of halloysite nanotubes and polydopamine, which is applied in the manufacture of rayon, single-component polyester rayon, and fiber chemical characteristics, can solve the problem of lack of ability to promote bone tissue healing and limited cell affinity , cumbersome graft modification methods, etc., to achieve excellent cell affinity and osteogenic activity, good cell affinity, and good biological functionality

Active Publication Date: 2016-05-11
JINAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, when inorganic nanoparticles are added to the polymer matrix, the inorganic particles and the polymer are usually physically combined, and the interfacial bonding force between the two phases is weak; and the high surface energy of the nano-inorganic particles makes the dispersion of the inorganic particles uneven and easy to agglomerate , which ultimately makes it difficult to effectively improve the mechanical properties of inorganic particle / polymer nanocomposites, and other properties are often not ideal
In Chinese patent ZL201210421335.1 (preparation method of modified halloysite nanotube-enhanced biodegradable polyester composite material), a large number of hydroxyl groups on the surface of halloysite nanotubes are used to introduce lactic acid or polylactic acid segments through chemical graft modification , which effectively solve the dispersion of halloysite nanotubes in the biodegradable polyester matrix and the interfacial compatibility of the two phases, endowing the material with good mechanical properties; however, halloysite nanotubes and their surface-modified lactic acid or poly The improvement of the cell affinity of lactic acid to the biodegradable polyester matrix is ​​extremely limited, and none of them have the ability to promote bone tissue healing; in addition, the grafting modification method involved is cumbersome and often requires high reaction temperature and organic solvents usage of

Method used

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  • Polydopamine-modified halloysite nanotube / polylactic acid composite material and preparation and application thereof
  • Polydopamine-modified halloysite nanotube / polylactic acid composite material and preparation and application thereof
  • Polydopamine-modified halloysite nanotube / polylactic acid composite material and preparation and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of polydopamine modified halloysite nanotubes comprises the following steps:

[0035] Prepare a tris aqueous solution with a concentration of 0.5g / L, and adjust its pH value to 8.5 with hydrochloric acid, dissolve dopamine in this buffer solution, and the concentration of dopamine in the solution is 0.5g / L; Tubes (HNTs) were uniformly added to the dopamine solution, wherein the mass ratio of halloysite nanotubes to dopamine was 2:1; the reaction system was magnetically stirred at room temperature for 12 hours; the mixture was transferred to a centrifuge tube, and the Centrifuge until the upper layer solution is transparent, remove the lower layer of solid, and vacuum-dry at 50° C. for 48 hours to obtain polydopamine-modified halloysite nanotubes (D-HNTs).

Embodiment 2

[0037] The preparation of polydopamine modified halloysite nanotubes comprises the following steps:

[0038] Configuration concentration is the tris aqueous solution of 1g / L, and its pH value is adjusted to 9 with hydrochloric acid, and dopamine is dissolved in this buffer solution, and dopamine concentration is 2g / L in the solution; 2g halloysite nanotube ( HNTs) were evenly mixed into the dopamine solution, wherein the mass ratio of halloysite nanotubes to dopamine was 0.5:1; the reaction system was magnetically stirred at room temperature for 24 hours; the mixture was transferred to a centrifuge tube, and centrifuged at 1500r / min to The solution in the upper layer was transparent, and the solid in the lower layer was removed, and dried in vacuum at 50° C. for 48 hours to obtain polydopamine-modified halloysite nanotubes (D-HNTs).

[0039] figure 1 Is HNTs in embodiment 2 ( figure 1 a) and D-HNTs ( figure 1 X-ray photoelectron spectroscopy in b). From figure 1 It can be...

Embodiment 3

[0041] The preparation of polydopamine modified halloysite nanotubes comprises the following steps:

[0042] The tris aqueous solution with a concentration of 1.5g / L is configured, and its pH value is adjusted to 8.5 with hydrochloric acid. Dopamine is dissolved in this buffer solution, and the concentration of dopamine in the solution is 5.0g / L; 5g halloysite nano Tubes (HNTs) were uniformly mixed into the dopamine solution, wherein the mass ratio of halloysite nanotubes to dopamine was 2:1; the reaction system was magnetically stirred at room temperature for 36 hours; the mixture was transferred to a centrifuge tube, and the Centrifuge until the upper layer solution is transparent, remove the lower layer of solid, and vacuum-dry at 50°C for 48 hours to obtain polydopamine-modified halloysite nanotubes; soak 1 g of polydopamine-modified halloysite nanotubes in 80 mL of simulated body fluid, simulate body fluid Composed of: Na + , 142.0mmol / L; K + , 5.5mmol / L; Mg 2+ , 1.5mm...

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Abstract

The present invention discloses a polydopamine-modified halloysite nanotube / polylactic acid composite material and preparation and application thereof. The polydopamine-modified halloysite nanotube / polylactic acid composite material comprises 0.05 to 60% by mass of polydopamine-modified halloysite nanotubes and 40 to 99.95% by mass of polylactic acid. By surface modification of the halloysite nanotubes, dispersion of the halloysite nanotubes in a polylactic acid matrix and interface compatibility of the halloysite nanotubes and the polylactic acid matrix can be solved, and the polylactic acid matrix can be effectively enhanced by the halloysite nanotubes; excellent cell affinity and osteogenic activity can be given to the polydopamine-modified halloysite nanotube / polylactic acid composite material, and more significantly, by the use of biological mineralization of a polydopamine layer on the surface of the halloysite nanotubes for formation of hydroxyapatite crystals, eventually good osteo inductivity can be given to the polydopamine-modified halloysite nanotube / polylactic acid composite material. The polydopamine-modified halloysite nanotube / polylactic acid composite material is simple in preparation method, mild in reaction conditions, low in price, and suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a polydopamine-modified halloysite nanotube / polylactic acid composite material and its preparation and application. Background technique [0002] Polylactic acid is a class of polymer materials approved by the US FDA (Food and Drug Administration, FDA) for the manufacture of biomedical materials. Polylactic acid is non-toxic, non-irritating, has good biocompatibility and biodegradability, and has been widely used as fracture internal fixation materials, tissue engineering scaffold materials, drug release carrier materials, etc.; however, polylactic acid materials have been widely used in practical applications. However, there are still problems such as unsatisfactory mechanical properties, biocompatibility and hydrophilicity to be improved. By adding nano-sized inorganic fillers such as hydroxyapatite, carbon nanotubes, nano-zinc oxide, silicon dioxide, etc. to th...

Claims

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Application Information

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IPC IPC(8): C08L67/04C08K9/04C08K7/24D01F6/92D01F1/10
CPCC08K7/24C08K9/08C08K2201/011D01F1/10D01F6/92C08L67/04
Inventor 罗丙红罗闯文伟周长忍
Owner JINAN UNIVERSITY
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