16 results about "Hydroxyapatite crystal" patented technology

The invention discloses a grading reaction crystallization recovery process and system for semiconductor fluorine-containing and phosphorus-containing waste liquid, the fluorine-containing and phosphorus-containing waste liquid and a lime solution react in a fluorine recovery crystallization reactor under the condition that the pH is 3-4 to form calcium fluoride crystals, and the calcium fluoride crystals are dehydrated to obtain calcium fluoride particle crystal products; the effluent of the fluorine recovery crystallization reactor, the calcium fluoride crystal dehydration filtrate, the lime solution and the calcium chloride solution react in a secondary reaction tank under the condition that the pH is 5-6, and calcium fluoride, fluorapatite, silicon dioxide and silicon-aluminum precipitates are removed through coagulation, flocculation and precipitation; effluent of the second-stage reaction tank, the lime solution and the calcium chloride solution react in the phosphorus recovery crystallization reactor under the condition that the pH is 7-8 to generate hydroxyapatite crystals, and the hydroxyapatite crystals are dehydrated to obtain hydroxyl calcium phosphate particle crystal products. Meanwhile, a high-purity calcium fluoride crystal product and a hydroxyl calcium phosphate crystal product are produced, and fluorine and phosphorus are recycled.

The application provides a method and application for rapidly preparing hydroxyapatite material, and belongs to the field of inorganic material synthesis. The application uses a calcium source solution containing glacial acetic acid and a phosphorus source solution containing hydroxyapatite crystal seeds and sugar alcohol solid as raw materials, uses micro-channel continuous flow technology and optimizes reaction parameters to rapidly prepare a crude hydroxyapatite, and then uses a joule heat treatment rapid high-low temperature technology to rapidly prepare a microspherical hydroxyapatite material, so that the preparation time is greatly shortened. The particle size range, specific surface area and pore size range of the material are 528-1053 nm, 95.72-117.71 m 2 / g and 0.5-83 nm respectively, which indicates that the material is a multi-level pore structure of micron level, high specific surface area, micropore and mesopore and macropore, can realize adsorption of organic matter-containing wastewater, the removal rate is more than 97.5%, is 1.87 times of the removal capacity of hydroxyapatite material without joule heat treatment, is outstanding in the field of organic matter adsorption and has good industrialization prospect.

The invention discloses an enamel secretion prolonging and thickness increasing method based on KLK4 alpha protein, and relates to the technical field of biomedicine and dental materials.According to the method, expression of the KLK4 alpha protein is specifically regulated and controlled, forward intervention in the secretion period in the enamel development process is achieved, synthesis and accumulation of enamel matrix protein are directly promoted, and the effect of prolonging the secretion period of the enamel is achieved. A recombinant lentiviral vector mediated gene transduction technology is utilized to specifically introduce the KLK4alpha gene into a dental embryo glazing cell and realize overexpression, and the expressed KLK4alpha protein remarkably delays the process of transformation from a secretion period to a mature period by regulating the secretion activity of the glazing cell, so that the expression level of the KLK4alpha protein is improved, and the expression level of the KLK4alpha protein is improved. The time sequence intervention effectively prolongs the secretion window period of key organic matrix components such as glaze protein, glaze protein and the like, so that before mineralization is started, the total amount of extracellular matrix net racks is substantially increased, a space is provided for nucleation of hydroxyapatite crystals, and finally, the thickness of a mineral phase is remarkably increased; and the protection performance of the dental crown structure is enhanced.

The invention belongs to the field of biomedicine, and relates to application of Herbacetin in prevention of renal nipple calcium spot related calcium oxalate kidney stone. The invention relates to an application of Herbacetin or pharmaceutically acceptable salt, ester, solvate, crystal form or prodrug thereof in preparation of a reagent for preventing renal papillary calcium spot related calcium oxalate kidney stone, the Herbacetin has the following structural formula: the Herbacetin is used for preventing and treating renal interstitial calcium salt deposition and Randall plaque progress for the first time, and experiments prove that the Herbacetin can be used for preventing and treating renal interstitial calcium salt deposition and Randall plaque progress. Herbacetin has the effect of inhibiting the inflammation induction of renal interstitial hydroxyapatite crystals on fibroblasts, and has the application prospect of improving the immune microenvironment of renal interstitial and the deposition of renal interstitial calcium salt.

The invention provides a method for rapidly preparing a hydroxyapatite material and application, and belongs to the field of inorganic material synthesis. According to the method, a calcium source solution containing glacial acetic acid and a phosphorus source solution containing hydroxyapatite seed crystals and sugar alcohol solids are used as raw materials, a micro-channel continuous flow technology is utilized, reaction parameters are optimized, crude hydroxyapatite is rapidly prepared, then a rapid high-low temperature technology of Joule heat treatment is adopted, and the hydroxyapatite is prepared. The rapid preparation of the microspherical hydroxyapatite material is realized, and the preparation time is greatly shortened. The particle size range, the specific surface area and the aperture range of the material are 528-1053 nm, 95.72-117.71 m < 2 > / g and 0.5-83 nm respectively, which indicates that the material is of a micron-scale, high-specific-surface-area, microporous, mesoporous and macroporous hierarchical pore structure, can realize adsorption of wastewater containing organic matters, has a removal rate of 97.5% or above, which is 1.87 times of the removal capacity of a non-joule heat-treated hydroxyapatite material, and has a good application prospect. The method has outstanding performance in the field of organic matter adsorption and has good industrialization prospects.

This invention relates to the field of biomaterials technology, providing a composite material for biomimetic repair of dental hard tissues, its preparation method, and its application. The preparation method of the composite material includes the following steps: mixing a carboxybetaine-phosphonic acid copolymer with a calcium salt to obtain solution A; adding an aqueous phosphate solution to solution A to carry out an in-situ reaction to obtain the composite material for biomimetic repair of dental hard tissues. In the composite material provided by this application, the carboxybetaine-phosphonic acid copolymer, under the action of calcium phosphate ions, can form an amelogenin-like nanoribbon structure, simultaneously driving amorphous calcium phosphate to undergo supramolecular self-assembly, constructing a composite material conforming to the "self-assembly-mineralization" synergistic mode. This composite material can directionally deposit dense enamel-like enamel pillar structures of hydroxyapatite crystals on the surface of demineralized enamel, efficiently inducing oriented structural regeneration of damaged enamel and significantly restoring the mechanical properties of demineralized enamel.

The invention relates to the technical field of materials, in particular to a hydrothermal reaction system of nanofibers as well as a preparation method and application of the hydrothermal reaction system. The reaction system comprises: a calcium source containing calcium ions; a phosphorus source containing phosphorus ions; a doping source containing lanthanum ions; the invention discloses a structure-directing agent capable of being selectively adsorbed on a hydroxyapatite crystal face under an alkaline condition and inducing one-dimensional directional growth. And an alkaline regulator. According to the preparation method disclosed by the invention, crystallization growth is directly carried out under a hydrothermal condition, and a high-temperature calcination step is not needed, so that the problems of fiber breakage, fusion and morphology collapse caused by macromolecular template decomposition and rapid crystal sintering are fundamentally avoided. The prepared nanofiber has ideal morphology with good continuity, uniform diameter and high length-diameter ratio, and can simulate the microstructure of natural collagen fiber more truly, thereby providing a more excellent biological microenvironment for cells.

The application provides a method for modifying an antibacterial film with a hydroxyapatite and silver composite coating and application, and belongs to the technical field of material modification. The application takes silver single element and hydroxyapatite crystals as sputtering sources, and prepares a hydroxyapatite and silver composite coating on the surface of a PVDF bone electroactive square film through a magnetron sputtering technology in an inert gas atmosphere to obtain an antibacterial film modified with the hydroxyapatite and silver composite coating. The antibacterial film modified with the hydroxyapatite and silver composite coating has superior biocompatibility, antibacterial performance and osteogenesis induction activity, and effectively solves the problems of poor bone integration, bone healing speed and effectiveness of the PVDF bone electroactive film in the prior art. The antibacterial film modified with the hydroxyapatite and silver composite coating is suitable for tissue engineering and bone defect repair, and expands the application scenarios of the PVDF bone electroactive film in the oral cavity and other parts.

The invention provides a self-assembled polypeptide material for bionic remineralization of demineralized enamel and application of the self-assembled polypeptide material, and belongs to the technical field of remineralization repair of demineralized enamel. The invention provides a self-assembled polypeptide material for bionic remineralization of demineralized enamel. The self-assembled polypeptide material comprises a self-assembled template unit, an enzyme digestion response unit and a bonding unit which are connected in sequence, the amino acid sequence of the self-assembly template unit is GYINFpSYE; the amino acid sequence of the enzyme digestion response unit is GPQGIWGQ; and the amino acid sequence of the bonding unit is DKTKREEVD. The self-assembled polypeptide material provided by the invention simultaneously realizes a template effect of an organic matter pre-organization, guides directional deposition of calcium and phosphorus ions, slowly degrades the organic matter, reduces organic occupation, and promotes dual effects of directional arrangement and phase change crystallization of amorphous calcium phosphate; the purposes of regularly and orderly arranged hydroxyapatite crystal formation, demineralized enamel structure repair and mechanical property recovery are achieved.

This invention provides the application of a TPE-Ketoalkyne probe in the preparation of a product specifically distinguishing urate and hydroxyapatite crystals. This product comprises a TPE-Ketoalkyne probe that specifically binds to urate crystals. This invention optimizes rapid imaging technology for MSU crystals in in vitro studies using the TPE-Ketoalkyne probe. The imaging effect is comparable to that of birefringent MSU crystals detected by clinical professionals using CPLM, especially in differentiating between different types of crystalline arthritis caused by MSU and HAP crystals. The fluorescence produced by the TPE-Ketoalkyne probe differs from ordinary fluorescence; it is non-quenchable and can be monitored for extended periods. This provides not only a good platform for basic research related to gout but also a new auxiliary means for clinical detection of gout.

The invention discloses a process and a system for fractional precipitation and resource recovery of wastewater containing phosphorus and aluminum, which are characterized in that the wastewater containing phosphorus and aluminum collected in a wastewater collection tank and a lime solution in a lime agent tank are respectively pumped into a pretreatment reaction tank, aluminum in the wastewater forms an aluminum phosphate precipitate under the condition that the pH is 5-6, and the aluminum phosphate precipitate enters a precipitation tank for mud-water separation; water is fed into a phosphorus recovery crystallization reactor, a calcium chloride agent pool and a lime agent pool are combined to add agents into the phosphorus recovery crystallization reactor, a crystallization reaction is carried out under the condition that the pH value is 7-8 to obtain hydroxyapatite crystals, and sludge separated from a sedimentation tank and the hydroxyapatite crystals are subjected to cleaning and dewatering treatment through a first cleaning and dewatering system and a second cleaning and dewatering system respectively; according to the method, efficient recovery of phosphorus and aluminum is achieved, the landfill problem of phosphorus-containing and aluminum-containing chemical sludge is avoided, and the pressure of natural resources is relieved.

The application relates to the field of fluorine pollution treatment, in particular to a preparation method of hydroxyapatite and application of the hydroxyapatite in fluorine removal of mine water, and solves the problem that the adsorption effect of the existing fluorine removal agent is still poor, thereby limiting the wide application of the fluorine removal agent in fluorine wastewater. In the preparation process of the fluorine removal agent, the hydroxyapatite is loaded on lanthanum-doped porous nanofibers, the adsorption active sites on the surface of the hydroxyapatite are increased through the electrostatic attraction or ion exchange of metal ions or metal oxides on the electrically negative pollutants, the adsorption effect on fluorine ions is improved, the cetyltrimethylammonium bromide changes the surface charge by embedding into the hydroxyapatite crystal lattice, the surface of the hydroxyapatite shows positive charge, the electrostatic action between the hydroxyapatite and F ‑ is strengthened, a large number of amino functional groups are contained on the chitosan, the fluorine ions can be reacted with the fluorine ions, the fluorine ions in water can be adsorbed on the surface through adsorption, and the fluorine removal purpose is achieved.

This application discloses a nerve conduit, comprising: mineralized collagen nanofibers doped with active elements; the mineralized collagen nanofibers containing hydroxyapatite crystals; the calcium element in the hydroxyapatite crystal lattice being replaced by a cation containing the active element, and / or, the phosphate group in the hydroxyapatite crystal lattice being replaced by anion containing the active element; the nerve conduit provided by this application, by introducing dopant elements, allows the cations or anions of the dopant elements to be effectively and controllably released from the phosphorus or calcium in the hydroxyapatite lattice of the mineralized collagen nanofibers, thereby effectively promoting the regeneration of human tissues such as nerves and blood vessels compared to nerve conduits without dopant elements.

The invention relates to the field of oral care, and discloses an oral composition as well as application and a use method thereof. The oral composition contains chondroitin sulfate, calcium salt and phosphorus salt, on the basis of the total mass of the oral composition, the content of the chondroitin sulfate is 0.05-2%, the content of the calcium salt is 0.1-0.3%, and the content of the phosphorus salt is 0.1-0.3%. The oral composition can significantly improve the quality of generated hydroxyapatite crystals, realizes deep and lasting sealing, enhances the acid erosion resistance, improves the remineralization efficiency, and has a significant market prospect.

The invention discloses mineralized collagen microspheres as well as a preparation method and application thereof. According to the preparation method, the collagen microspheres are prepared through an improved emulsification speed-controlled cross-linking method, so that the prepared microspheres are more concentrated in particle size distribution, more regular in morphology, more uniform in cross-linking degree and higher in mechanical strength; and tightly combining hydroxyapatite crystals with the prepared collagen microspheres by adopting an in-situ mineralization technology to obtain the mineralized collagen microspheres. Through in-situ mineralization, the mechanical strength of the collagen microspheres is enhanced, the obtained mineralized collagen microspheres are high in particle size uniformity and concentrated in size, richer communicated pore structures are formed through accumulation of the microspheres, permeation and attachment of cells are effectively promoted, and the bone repair process is accelerated.

This invention provides a Ni-supported catalyst of B-type substituted modified hydroxyapatite and its application in the dry reforming reaction of methane. The B-type substituted modified hydroxyapatite has a hydroxyapatite crystal structure and a specific surface area greater than 70 m². 2 The catalyst, in nanosheet form, contains Ni uniformly dispersed on a sheet-like support with a particle size of 1.0–6.0 nm and a Ni mass percentage of 1–10 wt%. Type B substituted modified hydroxyapatite was prepared via co-precipitation, and the active component Ni was loaded onto it via impregnation to obtain the catalyst. Type B substituted modified hydroxyapatite possesses advantages such as large specific surface area, abundant basic sites, and stable properties. With Ni highly dispersed on the support, it is used in low-temperature methane-carbon dioxide dry reforming reactions. At 500–700 °C, the conversion rate approaches the equilibrium conversion rate. The catalyst exhibits excellent resistance to carbon deposition, high activity, high stability, and low carbon deposition, making it beneficial for industrial applications.