Method for preparing high dispersancy nano hydroxyapatite colloidal sols in water solution

A nano-hydroxyapatite, high-dispersion technology, applied in chemical instruments and methods, phosphorus compounds, colloid chemistry, etc., can solve the problem of inability to synthesize hydroxyapatite nanoparticle sol, particle crystallinity, and particle morphology. Good, surfactant or stabilizer toxicity and other issues, to achieve the effect of improving mechanical properties, low requirements for experimental conditions, and high application value

Inactive Publication Date: 2008-05-28
TIANJIN UNIVERSITY OF TECHNOLOGY
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Problems solved by technology

But there are two problems: one is that the hydroxyapatite nanoparticle sol cannot be synthesized at a higher reaction temperature, so even if the hydroxyapatite sol is prepared, the crystallinity and particle

Method used

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  • Method for preparing high dispersancy nano hydroxyapatite colloidal sols in water solution

Examples

Experimental program
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Effect test

Embodiment 1

[0019] (1) Add 100ml of 0.01M soluble calcium salt solution to 100ml of sodium citrate solution with a concentration of 0.00884g / ml, stir vigorously and heat up to 80°C;

[0020] (2) After 20min, add dropwise a soluble phosphate solution whose concentration is 2 / 3 of the calcium salt solution concentration and whose volume is equal to it at a speed of 50ml / h;

[0021] (3) Keep the constant temperature for 2 hours, and keep stirring. After the reaction is over, let it cool naturally. After the reaction system drops to room temperature, add anhydrous ethanol with the same volume as the reaction system to the reaction system and let it stand for 30 minutes. Centrifuge for 10 minutes (4000r / m), and wash the precipitate with deionized water;

[0022] (4) Stir and disperse the freshly washed precipitate in deionized water while adding sodium hexametaphosphate solution with a concentration of 0.03g / ml until the color of the system changes from pure white to slightly white and translu...

Embodiment 2

[0025] (1) Add 200ml of 0.025M soluble calcium salt solution into 100ml of sodium citrate solution with a concentration of 0.009g / ml, stir vigorously and heat up to 90°C;

[0026] (2) After 20 minutes, add dropwise a soluble phosphate solution whose concentration is 2 / 3 of the calcium salt solution concentration and whose volume is equal to it at a speed not greater than 50ml / h;

[0027] (3) Keep the constant temperature for 2 hours, and keep stirring. After the reaction is over, let it cool naturally. After the reaction system drops to room temperature, add anhydrous ethanol with the same volume as the reaction system to the reaction system and let it stand for 30 minutes. Centrifuge for 10 minutes (4000r / m), and wash the precipitate with deionized water;

[0028] (4) Stir and disperse the freshly washed precipitate in deionized water while adding sodium hexametaphosphate solution with a concentration of 0.05g / ml until the color of the system changes from pure white to slight...

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Abstract

The invention discloses a preparation method of high dispersive nano-hydroxyapatite sol in water solution. The method takes sodium citrate and sodium hexametaphosphate as dispersing agents and adopts the two-step process to obtain the high dispersive sol of nano-hydroxyapatite which has the rod-shaped granules with the diameter of 10 to 20nm and the length of 100 to 300nm. The invention has simple process, low experimental conditions and no need of expensive equipments, at the same time, the invention does not introduce organic surfactant, and the stabilizer used is basically harmless to the environment and the biological bodies, furthermore, the invention adopts the two-step method to add the dispersing agents, so the invention can prepare the high dispersive nano-hydroxyapatite sol in a very wide temperature range; the invention makes use of the high dispersity of hydroxyapatite granules to solve the agglomeration problem of inorganic granules in nano-hydroxyapatite polymer compound biological materials, thereby greatly increasing the mechanical properties and the anisotropism of the mechanical properties of the materials and allowing the orthotropic mechanical properties to be more in line with the characteristics of human bone, so the invention can bring benefits to a plurality of patients with bone defects and is also the application direction of hydroxyapatite crystal on the medical clinical aspect.

Description

【Technical field】 [0001] The invention relates to the field of nano-hydroxyapatite biomaterials, in particular to a method for preparing highly dispersible nano-hydroxyapatite sol in an aqueous solution by using sodium citrate and sodium hexametaphosphate as dispersants. 【Background technique】 [0002] Due to its excellent biocompatibility and ion adsorption properties, hydroxyapatite has been paid attention to by people, and its application research has always been a scientific hotspot, especially in the application of nano-hydroxyapatite in biological materials, cancer inhibition, and drug carriers. and other fields have quite attractive potential. However, due to the ultra-high specific surface area of ​​nanoparticles, it is very easy to agglomerate, which greatly inhibits its application and development in related fields. Although some people have made some progress in the preparation of hydroxyapatite aqueous dispersion system by using organic surfactants or some inorg...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L31/02C01B25/32B01J13/00
Inventor 谭军军陈民芳廉玉营
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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