105 results about "Human bone" patented technology

The invention relates to the technical field of bone tissue engineering and regenerative medicine, and discloses a stem cell-loaded bionic bone scaffold material, which comprises a bone scaffold main body, the bone scaffold main body is formed by compounding hydroxyapatite and a biodegradable high-molecular polymer and has a porous structure, the porosity is 70%-90%, the aperture range is 100-500 microns, and pores are communicated with one another; a vascularization induction factor slow release system is arranged in the porous structure of the bone scaffold main body, the stem cell-loaded bionic bone scaffold material does not need to take the autologous bone of a patient, and the problems of donor injury and limited sources are avoided; the composite scaffold is matched with low-immunogenicity stem cells, so that the risks of immunological rejection and disease transmission are avoided; the material has the advantages of good biocompatibility, mechanical matching with human bones, degradability, no secondary operation, promotion of vascular regeneration and stem cell osteogenesis, and realization of bone regeneration integration.

The invention discloses a bionic Voronoi-nickel titanium-hydrogel heterostructure implant and a preparation method thereof, and relates to the technical field of bone implantation, the construction of a Voronoi porous structure and the preparation of a bionic Voronoi-nickel titanium skeleton are completed through an innovative design method by referring to the structural concept of human bone trabecula, and then the bionic Voronoi-nickel titanium skeleton is used as a substrate to prepare the bionic Voronoi-nickel titanium hydrogel heterostructure implant. And preparing the bionic Voronoi-nickel titanium-hydrogel heterostructure implant by adopting a drying gel forming method. The implant integrates the mechanical advantages of high strength and low modulus of the nickel-titanium alloy and the structural characteristics of high connectivity and high specific surface area of the bionic Voronoi porous structure, the defect that hydrogel is weak in bearing is effectively overcome, meanwhile, the hydrogel has the buffering and energy absorbing effects, multifunctional time sequence delivery and release of antibiosis, anti-inflammation and bone regeneration promotion can be achieved, and the requirements of all stages of bone repair are met.

The invention relates to the technical field of biology, in particular to application of a GGPS1 activator, a pharmaceutical composition, a kit and a method. The invention relates to bone metabolism regulation and bone regeneration. It is found that improvement of GGPS1 expression / activity can activate TGF-beta / Smad2 / 3 by down-regulating LTBP1, so that human bone marrow mesenchymal stem cells are converted from adipogenesis to osteogenesis, and bone formation and bone defect repair are promoted. The invention provides a drug containing a GGPS1 activator and a controlled release composition for implantation, which are used for osteoporosis, bone mass reduction, delayed fracture healing and the like. The invention also provides an in-vitro screening and evaluation method and a detection kit, and the indexes such as p-Smad2 / 3, alizarin red, oil red O and the like are used for judgment. The invention realizes upstream heavy balance and has the advantages of bone promotion and fat suppression.

A device (100) for mobilizing the human bone-tendon system, the device comprising: - a knee protector (2) arranged to cover a knee (3) of a human user to hold said knee in said knee protector and to exert a mobilization force on the knee covered by said knee protector, said mobilization force exerting pressure on said knee and directing towards a load bearing surface (5) arranged to support the pelvis of the user, and - means (6) for increasing the mobilization force.

The invention discloses a bone repair material as well as a preparation method and application thereof. The bone repair material is prepared from recombinant human collagen, recombinant human bone morphogenetic protein 2 and hydroxyapatite, wherein the ratio of the inorganic matter to the organic matter in the bone repair material is (64-66): (36-34). The bone repair material disclosed by the invention takes the recombinant human collagen as a core raw material, so that the components and the structure of the prepared material are ensured to be highly consistent with those of natural bone tissues; secondly, by adding the recombinant human bone morphogenetic protein 2, the osteogenic activity of the material is further enhanced. The finally obtained recombinant human collagen active bone repair material completely retains the triple helix structure of the recombinant human collagen, so that the recombinant human collagen active bone repair material has complete biological activity, and also has the outstanding advantages of good osteogenic activity, no disease and virus transmission risk and no immunogenicity.

The invention discloses sclera shell slurry suitable for ceramic photocuring 3D printing and a preparation method of the sclera shell slurry, and relates to the technical field of biomedical materials and additive manufacturing, and the sclera shell slurry comprises 2.0%-5.0% wt of methacrylated gelatin, 70%-90% wt of nano-hydroxyapatite, 10%-25% wt of a photosensitive resin solution, 1%-3% wt of a composite photoinitiator and 1%-5% wt of a composite dispersion stabilizer. The high-solid-content slurry and the optimized sintering process disclosed by the invention ensure that the final ceramic product has enough mechanical strength similar to that of human bones, scar contracture can be effectively resisted, and a long-term stable physical barrier is provided. And the process is stable, the forming precision is high, high fluidity and low viscosity of the slurry are guaranteed through unique powder grading and a dispersion stable system, the photocuring printing process is smooth, the forming structure resolution ratio is high, and defects are few. The whole set of process has clear parameters and good reproducibility.

The invention discloses polymethyl methacrylate bone cement as well as a preparation method and application thereof, and belongs to the technical field of bone cement. The elasticity modulus of the polymethyl methacrylate bone cement does not exceed 2GPa, and the polymerization peak temperature of the polymethyl methacrylate bone cement does not exceed 90 DEG C. The polymethyl methacrylate bone cement has relatively low elastic modulus and polymerization temperature, is beneficial to improving the biocompatibility and matching degree of the bone cement and human bone tissues, and can be used for reducing thermal damage to surrounding tissues or nerves caused by polymerization heat release; or is used for improving elastic matching with human bone tissues so as to reduce the risk of stress-related complications. The preparation method of the polymethyl methacrylate bone cement is simple and easy to operate, and can be used for industrial production.

1. Name of the product in this design: Planer handle. 2. Purpose of this design: To be used in surgical procedures in conjunction with planers or drills to treat human bone and / or soft tissues. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

1. Name of the product in this design: Bone Carving Knife. 2. Purpose of this design: This design is used for human bone repair in surgical procedures. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The application discloses a kind of biomimetic Voronoi-nickel titanium-hydrogel heterostructure implants and preparation method thereof, it is related to bone implant technical field, draw lessons from the structural concept of human bone trabecula, complete the preparation of Voronoi porous structure construction and biomimetic Voronoi-nickel titanium skeleton by innovative design method, again with the biomimetic Voronoi-nickel titanium skeleton as base, adopt drying gel method to prepare biomimetic Voronoi-nickel titanium-hydrogel heterostructure implant.The implant integrates the mechanical advantages of high strength, low modulus of nickel titanium alloy and the structural characteristics of high connectivity, high specific surface area of biomimetic Voronoi porous structure, effectively makes up the short board of hydrogel bearing weakness, while hydrogel has buffering energy absorption function, can realize the multi-functional time sequence release of antibacterial, anti-inflammatory, bone regeneration promotion, adapt to the needs of each stage of bone repair.

This invention discloses a method for preparing a 3D-printed hydrogel scaffold for cartilage repair, comprising: providing methacrylamide chitosan; providing 2-([1,1-biphenyl]-4-ylcarbamoyl)benzoic acid@polylactic acid-glycolic acid copolymer microspheres; obtaining a 3D-printed bio-ink for cartilage repair using methacrylamide chitosan, 2-([1,1-biphenyl]-4-ylcarbamoyl)benzoic acid@polylactic acid-glycolic acid copolymer microspheres, recombinant collagen CF-1552, and lithium magnesium silicate as main raw materials; and obtaining a 3D-printed bio-ink for cartilage repair using the 3D-printed bio-ink for cartilage repair as a raw material to obtain a 3D-printed hydrogel scaffold for cartilage repair. This 3D-printed hydrogel scaffold has advantages such as antibacterial properties and the ability to promote the differentiation of human bone marrow mesenchymal stem cells (hBMSCs) into chondrocytes, and can be used for cartilage repair, potentially bringing new curative opportunities for cartilage injury diseases.

The application discloses a human variable cross-section bone thickness detection method and system based on ultrasonic guided waves, the system derives a human cortical bone dispersion curve through an anisotropic model, obtains an inverted cortical bone thickness distribution rule by using the dispersion curve, and further obtains a cortical bone two-dimensional thickness distribution image, and the system has no radiation hazard to patients, is low in cost, high in real-time performance, wide in application range, and convenient and fast in obtaining bone thickness measurement results, and takes into account the uneven human bone thickness distribution, and has important value in practice.

The invention discloses a model construction method of a gradient random porous structure of a simulated bone trabecula, a white calendite piezoelectric bone scaffold and a preparation method of the white calendite piezoelectric bone scaffold, and the model construction method provided by the invention is a design method based on a Thiessen polygon porous structure with seed point release gradient change and volume scaling coefficient linear gradient change. In the body center scaling process, interpolation calculation is conducted on scaling coefficients from the axis to the outermost end in the cylindrical domain in the radial direction, and therefore the model of the stochastic gradient porous structure with the pore diameter decreasing from inside to outside in the radial direction and the pore edge diameter increasing from inside to outside in the radial direction is finally formed, by designing the formula and process parameters of the white calcium stone ceramic slurry, the possible problems of over-curing, cracking and the like are avoided, and the white calcium stone piezoelectric ceramic bone scaffold with excellent bonding performance is prepared by adopting a 3D printing photocuring printing technology.

The application discloses a functional high-collagen-peptide chicken egg feed additive and a preparation method thereof, relates to the technical field of laying hen feed, and raw materials of the feed additive and weight proportions of the raw materials are as follows: 1 part of arosa chinensis extract, 2 parts of origanum majorana raw powder, 1 part of artemisia leaf raw powder and 7-11 parts of collagen peptide; the feed additive formed by mixing the arosa chinensis extract, the origanum majorana raw powder, the artemisia leaf raw powder and the collagen peptide can effectively improve the Haff index of the chicken egg, the proportion of thick egg white, the viscosity and the eggshell quality in a short period of time and prolongs the egg product preservation period; the content of the collagen peptide in the chicken egg is effectively improved in a short period of time, the nutritional value of the chicken egg is improved, the method of supplementing the collagen peptide by eating the chicken egg plays a promoting role on human bone health, and the collagen peptide is supplemented by using egg white as a mask, so that the beauty function of repairing skin damage and preventing pigment deposition is realized.

This invention provides a PET image attenuation correction method, apparatus, and device, comprising: acquiring an unattenuated PET image and inputting it into a first generative adversarial network (GAN) to output a predicted human tissue distribution map; inputting the predicted human tissue distribution map and the unattenuated PET image into a second GAN cascaded with the first GAN to output a corresponding virtual CT image; and using the virtual CT image to perform attenuation correction on the unattenuated PET image to obtain an attenuated PET image. The human bone tissue enhancement generation framework constructed based on the GAN in this application exhibits significantly richer skeletal structures in CT images generated from NAC-PET images; furthermore, the CT images generated based on the human bone tissue enhancement generation framework constructed in this application achieve better results in terms of grayscale similarity and tissue consistency, thereby improving the accuracy of PET attenuation correction.

The invention belongs to the technical field of tissue engineering, and particularly relates to a bio-ink system for osteochondral repair as well as a preparation method and application of the bio-ink system. The system comprises first bio-ink and second bio-ink which are respectively used for simulating cartilage and bone tissue. The first biological ink is prepared from methacrylic acid gelatin, acellular extracellular matrix powder, aldehyde modified natural polysaccharide, a photoinitiator and a transforming growth factor; the second biological ink is prepared from methacrylic acid gelatin, acellular extracellular matrix powder, nano-hydroxyapatite, aldehyde modified natural polysaccharide, a photoinitiator and human bone morphogenetic protein BMP-2. The bio-ink system can guarantee smooth extrusion and interlayer fusion in the printing process; the constructed bionic microenvironment and the affinity effect of the bionic microenvironment on growth factors are suitable for 3D printing construction of the osteochondral integrated bionic scaffold and have good clinical transformation potential.

The application discloses a kind of biological composite material for regulating magnesium ion release by surface layer channel and preparation thereof, belong to the technical field of biomedical materials.The surface layer of the composite material is porous zinc alloy, and the core is medical magnesium alloy.The preparation method includes first using atmosphere smelting combined with nested extrusion process to obtain zinc-magnesium composite bar, then preparing porous zinc alloy surface layer on the surface of the composite bar by laser drilling.The application realizes the controllable degradation of the overall material and the controllable release of magnesium ions.The surface layer zinc alloy slows down the degradation rate of the core magnesium alloy, and the surface layer regulates the magnesium ion release dose through channel size and distribution, i.e., it achieves the use of magnesium ions to promote the bone effect and promote the initial osteogenesis of the composite implant material, and through the volume ratio design of the surface layer zinc alloy and the core magnesium alloy, the degradation rate is regulated to match the bone tissue healing process.The material has moderate mechanical properties, and the elastic modulus is similar to that of human bone.The preparation process is simple, precise, and suitable for mass production.

The utility model discloses a humerus handle beneficial to large and small tubercle reconstruction, which comprises a humerus prosthesis handle, a cover plate and a fixing screw, a screw hole is arranged on the humerus prosthesis handle, a joint surface is fixed on the humerus prosthesis handle, the joint surface is matched with a cambered surface joint head, and the cover plate is fixed on the cover plate. The humerus prosthesis handle is mutually fixed with a human body bone block through the cover plate and the fixing screw. According to the humerus handle beneficial to large and small tubercle reconstruction, the overall operation is simple, a doctor does not need to conceal a suture binding mode and a mechanical structure when a patient moves later, compared with a traditional suture binding mode, the risk that bone fragments are separated from the binding position is high, the design has no risk, fixation is firm, the humerus prosthesis handle is made of a titanium alloy material, and the use is convenient. The screw and the cover plate are also made of titanium alloy materials, biocompatibility is guaranteed, meanwhile, strength is achieved, the cover plate and the screw are in spherical connection, the device can better adapt to the shape of a bone block, and the adaptability of the device is improved.

The application discloses a polymethyl methacrylate bone cement as well as a preparation method and application thereof, and belongs to the technical field of bone cement. The polymethyl methacrylate bone cement is constructed with a rigid-elastic composite structure by introducing polyurethane and / or polycaprolactone, and realizes the effects of elastic modulus regulation and polymerization heat release inhibition; the obtained polymethyl methacrylate bone cement has an elastic modulus of 0.6 GPa to 2 GPa, which is much lower than that of a traditional product; the polymerization peak temperature can be as low as 47.8 DEG C, which is more than 50 DEG C lower than that of the traditional bone cement; meanwhile, the compressive strength can be kept not lower than 70 MPa, which fully meets the requirements of an industry standard. The preparation method of the polymethyl methacrylate bone cement is simple and can be used for industrial production; the prepared polymethyl methacrylate bone cement can significantly reduce the thermal damage of polymerization heat release to surrounding tissues, improve the elastic matching with human bone tissues, and is suitable for clinical bone repair scenes such as vertebroplasty.

This invention discloses a method for preparing and using a long-acting antitumor organic and inorganic bone binder, which is prepared by polymerization, blending, and freeze-drying of porous calcium phosphate and antioxidant-grafted Tremella fuciformis polysaccharide hydrogel. The porous calcium phosphate is prepared by controlling its porous structure and composition to achieve degradation, thereby slowly releasing calcium ions, improving osteogenic properties, and achieving high bonding strength with human bone at the postoperative bone tumor defect site. Simultaneously, leveraging the high bonding strength and long-acting antitumor properties of the Tremella fuciformis polysaccharide hydrogel grafted with one or two antioxidants such as ascorbic acid, tea polyphenols, flavonoids, and tocopherols, the porous calcium phosphate and antioxidant-grafted Tremella fuciformis polysaccharide hydrogel are combined to form a covalently cross-linked network structure, further improving the bonding strength of the bone binder, promoting osteogenic properties with host bone tissue, and providing a long-lasting antitumor cycle.

This utility model discloses a skull base defect repair device with adjustable function, including a card body. The front side of the card body is convex, and the rear side is concave. A clamping part is provided at the center of the front side of the convex side. The clamping part is arranged in an "I" shape. With the card body and clamping part provided, compared with other rigid reconstruction materials, this invention uses β-tricalcium phosphate material that can absorb human bone. It is made by mechanical processing or 3D printing technology. It has good biodegradability, biocompatibility, and non-toxicity. It can be used as an ideal bone substitute material for rigid reconstruction. In addition, this application also has the advantages of being ultra-thin, having stable clamping and good sealing effect, which can greatly reduce the occurrence of complications such as rejection reaction, postoperative cerebrospinal fluid leakage, postoperative brain tissue protrusion, and intracranial infection.

This invention provides a biocompatible β This invention relates to a method for composite modification of titanium alloy surfaces, belonging to the technical field of alloy modification methods. The invention includes applications in medical... β This invention involves introducing bioactive particles onto the surface of a titanium alloy substrate, performing friction stir processing (FSP) on the substrate to introduce bioactive particles and construct a gradient grain structure, and then subjecting the FSP-treated substrate to compressed plasma flow (CPF) treatment to achieve uniform distribution of bioactive particles and construct a topology with an average surface roughness of 3-6 μm suitable for cell growth. The invention precisely controls the amount of bioactive particles introduced and constructs a gradient grain structure through friction stir processing (FSP); simultaneously, compressed plasma flow (CPF) technology achieves uniform distribution of bioactive particles and an ideal surface roughness of 3-6 μm on the titanium alloy surface. Ultimately, this significantly improves the cell adhesion, proliferation capacity, and osteogenic properties of the material surface, solving the technical problem of low integration efficiency of traditional titanium alloy implants with human bone tissue.

1. Name of the designed product: packing bag (human bone). 2. Use of the designed product: used for packing artificial bone product, also used for packing other medical products. 3. Design points of the designed product: in shape. 4. Picture or photo showing the design points: perspective view.

The application discloses a medical implant titanium-magnesium alloy material and a preparation method thereof. The method comprises the following steps: mixing and drying TC4 titanium alloy powder and Mg metal powder; sealing the mixture in a furnace, and vacuumizing; adopting a hot isostatic pressing process to heat, pressurize and preserve pressure in an argon atmosphere, and processing the mixture into a medical implant structure; utilizing NaCl solution chemical corrosion to form pores, forming a porous TiMg alloy material; placing the porous TiMg alloy material in high-purity oxygen to form an oxide layer; and obtaining the medical implant titanium-magnesium alloy material. The titanium-magnesium alloy material has better elasticity modulus and strength which are matched with human bones, and can form porous characteristics in situ after being implanted into a human body, effectively promotes bone tissue ingrowth and bone tissue healing, and better promotes fusion and fixation of human bones and the implant.

The invention relates to the technical field of biological medicines, in particular to a galangal-sourced nano-vesicle as well as a preparation method and application thereof. The method specifically comprises the following steps: crushing rhizoma alpiniae officinarum rhizomes, mixing the crushed rhizoma alpiniae officinarum rhizomes with a buffer solution, soaking in a water bath, and filtering to remove solids so as to obtain a crude extract; and sequentially carrying out centrifugal treatment on the crude extract for four times, so as to obtain the galangal-derived nano-vesicles. The invention provides a method for extracting nano-vesicles from galangal, and finds for the first time that the obtained vesicles can promote osteogenic differentiation of human bone marrow mesenchymal stem cells with high efficiency and low toxicity, the effect of the vesicles is obviously superior to that of known active component galangin, and the cytotoxicity is obviously lower; the invention provides raw materials and methods with great potential for developing novel and safe anti-osteoporosis drugs or inducers.

This invention discloses a biomimetic helical chiral porous bone repair and bone augmentation scaffold, comprising: a scaffold body composed of an array of multiple lattice units, each lattice unit being a biomimetic trabecular bone cell; the lattice units follow the natural helical arrangement of human bone trabeculae, forming a continuous and interconnected helical channel network within the scaffold body; the lattice units are distributed in a helical gradient along the radial direction of the scaffold body, and the outer wall of the scaffold body has a protruding structure integrally formed with the lattice units. This invention, through the deep coupling of the biomimetic helical chiral structure and cellular fluid dynamics, overcomes the limitations of traditional scaffolds with "static channels," forming a composite flow field of "high-speed guidance - low-speed vortex," effectively solving the problem of "nutrient islands," and significantly improving the survival rate and quality of osteoblasts in the central region.

The present invention is applied to the technical field of composite medical materials. Disclosed is an organic-inorganic composite medical material, the material consisting of organic components and inorganic components, the organic components comprising collagen, hyaluronic acid and chitosan, and the inorganic components being nano-hydroxyapatite and silica nanoparticles. Among the inorganic components of the organic-inorganic composite medical material, the nano-hydroxyapatite has the characteristics of good biocompatibility and osteoconductivity and thus enables the composite material to integrate with human bones; and the silica nanoparticles which have the characteristics of enhancing the strength and stability of materials improve the stability of the composite material. Among the organic components, proteins which are natively present in the human body and mainly comprise collagen can improve the biological activity and flexibility of the composite material, and promote cell growth and tissue regeneration; the collagen provides an attachment and growth environment for cells; and the hyaluronic acid is used for moisturizing and has an effect of promoting cell growth.

This invention relates to the field of biomedical materials technology and provides an application of obeticholic acid-exosome nanoparticles in the treatment of hepatic ischemia-reperfusion injury. The obeticholic acid-exosome nanoparticles are prepared by combining exosomes and obeticholic acid using an ultrasonic method, wherein the exosomes are derived from human bone marrow mesenchymal stem cells. The method for preparing the obeticholic acid-exosome nanoparticles is simple and easy to mass-produce. By utilizing exosomes derived from mesenchymal stem cells, the obeticholic acid-exosome nanoparticles improve the drug's targeting in vivo and prolong its circulation time, achieving targeted delivery of obeticholic acid to the liver, thus providing a new targeted therapeutic strategy for hepatic ischemia-reperfusion injury.

1. The name of the design product: micro-aging bone age instrument detection device. 2. The use of the design product: for human bone age determination. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view. 5. The bottom of the design product is not easy to see or not visible during use, omit the top view.

The application discloses a kind of high-strength low elastic modulus Ti-Nb-Zr biomedical titanium alloy and preparation method thereof, alloy ingot is prepared using vacuum melting, and solid solution quenching, titanium alloy plate is prepared using cold working large deformation.The biomedical titanium alloy preparation method of the application, control cold working deformation rate reaches more than 90%.The alloy obtained using the method of the application has low modulus, high strength, superelasticity, shape memory, damping characteristics, corrosion resistance and high biocompatibility.The modulus of the titanium alloy obtained by the application is similar to the modulus of human bone, and can be used as a bone graft or medical device.The Ti-Nb-Zr alloy prepared using the method of the application has excellent performance, the tensile strength is not less than 1000MPa, the elastic modulus is not higher than 60GPa, and the superelastic strain is not less than 2.2%.