147 results about "Human bone" patented technology

The invention belongs to the technical field of biological genetic engineering, and relates to a high-risk myelodysplastic syndrome screening gene and a diagnostic kit thereof. The invention provides an application of detecting YTHDF2, METTL3 and NAT10 gene expression of bone marrow cells of high-risk MDS patients as a specific molecular marker for screening the high-risk myelodysplastic syndrome, and by detecting mRNA expression levels of the YTHDF2, METTL3 and NAT10 genes, the screening of the patients in the high-risk myelodysplastic syndrome is facilitated. Meanwhile, treatment and prognosis evaluation of patients with high-risk myelodysplastic syndromes can be better guided. Only the bone marrow fluid of the patient needs to be extracted and collected during bone marrow cytology examination of the patient, the patient compliance is good, the bone marrow fluid is selected from human bone marrow fluid mononuclear cells, the detection result is more accurate, and the method is suitable for clinical large-scale application.

The invention provides a gradient density metal implant additive manufacturing method, and relates to the technical field of selective laser melting additive manufacturing, according to the method, continuous gradient density distribution of a metal implant from an outer layer to an inner layer is achieved through multi-mode sensor fusion and a self-adaptive control algorithm, biomechanical characteristics of a skeleton are accurately simulated, and the manufacturing precision of the metal implant is improved. The step of designing a porous structure is omitted; cortical bone (high density) and cancellous bone (porous) structures of human bones can be accurately simulated, and the biomechanical suitability of the implant is improved.

The present invention relates to a bone trauma repair bone paste and a preparation method thereof, belonging to the technical field of biomedical material manufacturing. The bone paste of the present invention is prepared by mixing nano calcium phosphate biphasic ceramics, biomimetic mineralized collagen fibers, biodegradable polymers, modified hyaluronic acid, β-cyclodextrin-coated recombinant human bone morphogenetic protein-7, angiogenesis promoters and immunomodulatory additives in a certain proportion; the nano calcium phosphate biphasic ceramics are hydroxyapatite and β-tricalcium phosphate biphasic ceramics; the biomimetic mineralized collagen fibers are prepared by mineralizing freeze-dried fibers of type I collagen admixed with hydroxypropyl chitosan; the modified hyaluronic acid is hyaluronic acid-thiol and hyaluronic acid-hydrazide; the angiogenesis promoter is a polylactic acid sustained-release microsphere loaded with tanshinone and hydroxy polyethylene glycol biotin; the immunomodulatory additive is disodium glycyrrhizinate, lentinan and astragalus polysaccharide. The bone paste can effectively improve the bone induction ability, promote angiogenesis and reduce the risk of immunogenicity.

The invention relates to the technical field of biomedical materials, in particular to a preparation process of novel composite bone cement with biological activity, which comprises the following steps: calcining calcium phosphate in a calcining furnace at 800-1000 DEG C for 3 hours, cooling to 20 DEG C, grinding the calcium phosphate by using a grinding machine until the diameter is less than 100 mu m, and drying to obtain the novel composite bone cement with biological activity. Calcium phosphate micro powder is obtained; by fusing the calcium phosphate, the nano-hydroxyapatite, the bioglass and the collagen, the material has a mechanical support function of an inorganic phase and biological activity of an organic phase, the nano-hydroxyapatite is extremely similar to human bone minerals and can promote osteoblast attachment and growth, and the collagen constructs a bionic microenvironment and accelerates new bone formation, so that the material can be used for treating osteoporosis. The bone repair efficiency is obviously improved.

The invention relates to the technical field of bone tissue engineering and regenerative medicine, and discloses a stem cell-loaded bionic bone scaffold material, which comprises a bone scaffold main body, the bone scaffold main body is formed by compounding hydroxyapatite and a biodegradable high-molecular polymer and has a porous structure, the porosity is 70%-90%, the aperture range is 100-500 microns, and pores are communicated with one another; a vascularization induction factor slow release system is arranged in the porous structure of the bone scaffold main body, the stem cell-loaded bionic bone scaffold material does not need to take the autologous bone of a patient, and the problems of donor injury and limited sources are avoided; the composite scaffold is matched with low-immunogenicity stem cells, so that the risks of immunological rejection and disease transmission are avoided; the material has the advantages of good biocompatibility, mechanical matching with human bones, degradability, no secondary operation, promotion of vascular regeneration and stem cell osteogenesis, and realization of bone regeneration integration.

The invention discloses a bionic Voronoi-nickel titanium-hydrogel heterostructure implant and a preparation method thereof, and relates to the technical field of bone implantation, the construction of a Voronoi porous structure and the preparation of a bionic Voronoi-nickel titanium skeleton are completed through an innovative design method by referring to the structural concept of human bone trabecula, and then the bionic Voronoi-nickel titanium skeleton is used as a substrate to prepare the bionic Voronoi-nickel titanium hydrogel heterostructure implant. And preparing the bionic Voronoi-nickel titanium-hydrogel heterostructure implant by adopting a drying gel forming method. The implant integrates the mechanical advantages of high strength and low modulus of the nickel-titanium alloy and the structural characteristics of high connectivity and high specific surface area of the bionic Voronoi porous structure, the defect that hydrogel is weak in bearing is effectively overcome, meanwhile, the hydrogel has the buffering and energy absorbing effects, multifunctional time sequence delivery and release of antibiosis, anti-inflammation and bone regeneration promotion can be achieved, and the requirements of all stages of bone repair are met.

The present invention belongs to the field of biological genetic engineering technology and relates to high-risk myelodysplastic syndrome screening genes and diagnostic kits. The present invention provides an application of detecting the expression of YTHDF2, METTL3, and NAT10 genes in bone marrow cells of high-risk MDS patients as a specific molecular marker for screening high-risk myelodysplastic syndrome. By detecting the expression levels of YTHDF2, METTL3, and NAT10 genes mRNA, it helps to screen patients with high-risk myelodysplastic syndrome and better guide the treatment and prognosis evaluation of patients with high-risk myelodysplastic syndrome. The present invention only needs to extract the patient's bone marrow fluid and collect it together when the patient undergoes bone marrow cytology examination. The patient compliance is good, and the material is taken from human bone marrow fluid mononuclear cells. The test results are more accurate and suitable for large-scale clinical application.

The invention relates to the technical field of biology, in particular to application of a GGPS1 activator, a pharmaceutical composition, a kit and a method. The invention relates to bone metabolism regulation and bone regeneration. It is found that improvement of GGPS1 expression / activity can activate TGF-beta / Smad2 / 3 by down-regulating LTBP1, so that human bone marrow mesenchymal stem cells are converted from adipogenesis to osteogenesis, and bone formation and bone defect repair are promoted. The invention provides a drug containing a GGPS1 activator and a controlled release composition for implantation, which are used for osteoporosis, bone mass reduction, delayed fracture healing and the like. The invention also provides an in-vitro screening and evaluation method and a detection kit, and the indexes such as p-Smad2 / 3, alizarin red, oil red O and the like are used for judgment. The invention realizes upstream heavy balance and has the advantages of bone promotion and fat suppression.

The invention relates to the technical field of medical instruments, in particular to a device and method for testing the fixing strength of a wired anchor, and the device comprises a lower tool which comprises a sliding seat and two clamping assemblies, the two clamping assemblies are arranged on the sliding seat in a sliding manner, and the clamping assemblies move oppositely to clamp a test block; the test block is a polyurethane block, a through hole is formed in the test block, four groups of tendon ligament simulants vertically penetrate through the through hole, anchor nails with lines are fixed in the through hole, and the anchor nails with lines are screwed into or knocked into the through hole and extrude and fix the tendon ligament simulants; the upper tool comprises a box body and a balance assembly, the balance assembly is arranged in the box body, the lower end of the balance assembly is provided with a chuck for clamping a tendon ligament simulant, the lower tool clamps a test block for simulating a human skeleton, and the upper tool clamps the tendon ligament simulant located at the upper end of an anchor nail with a line in the test block; the problems that an independent anchor is difficult to clamp due to the appearance and clamping is prone to deformation due to the material strength of the anchor with the line are solved.

A device (100) for mobilizing the human bone-tendon system, the device comprising: - a knee protector (2) arranged to cover a knee (3) of a human user to hold said knee in said knee protector and to exert a mobilization force on the knee covered by said knee protector, said mobilization force exerting pressure on said knee and directing towards a load bearing surface (5) arranged to support the pelvis of the user, and - means (6) for increasing the mobilization force.

The invention discloses a bone repair material as well as a preparation method and application thereof. The bone repair material is prepared from recombinant human collagen, recombinant human bone morphogenetic protein 2 and hydroxyapatite, wherein the ratio of the inorganic matter to the organic matter in the bone repair material is (64-66): (36-34). The bone repair material disclosed by the invention takes the recombinant human collagen as a core raw material, so that the components and the structure of the prepared material are ensured to be highly consistent with those of natural bone tissues; secondly, by adding the recombinant human bone morphogenetic protein 2, the osteogenic activity of the material is further enhanced. The finally obtained recombinant human collagen active bone repair material completely retains the triple helix structure of the recombinant human collagen, so that the recombinant human collagen active bone repair material has complete biological activity, and also has the outstanding advantages of good osteogenic activity, no disease and virus transmission risk and no immunogenicity.

The invention discloses sclera shell slurry suitable for ceramic photocuring 3D printing and a preparation method of the sclera shell slurry, and relates to the technical field of biomedical materials and additive manufacturing, and the sclera shell slurry comprises 2.0%-5.0% wt of methacrylated gelatin, 70%-90% wt of nano-hydroxyapatite, 10%-25% wt of a photosensitive resin solution, 1%-3% wt of a composite photoinitiator and 1%-5% wt of a composite dispersion stabilizer. The high-solid-content slurry and the optimized sintering process disclosed by the invention ensure that the final ceramic product has enough mechanical strength similar to that of human bones, scar contracture can be effectively resisted, and a long-term stable physical barrier is provided. And the process is stable, the forming precision is high, high fluidity and low viscosity of the slurry are guaranteed through unique powder grading and a dispersion stable system, the photocuring printing process is smooth, the forming structure resolution ratio is high, and defects are few. The whole set of process has clear parameters and good reproducibility.

The invention discloses polymethyl methacrylate bone cement as well as a preparation method and application thereof, and belongs to the technical field of bone cement. The elasticity modulus of the polymethyl methacrylate bone cement does not exceed 2GPa, and the polymerization peak temperature of the polymethyl methacrylate bone cement does not exceed 90 DEG C. The polymethyl methacrylate bone cement has relatively low elastic modulus and polymerization temperature, is beneficial to improving the biocompatibility and matching degree of the bone cement and human bone tissues, and can be used for reducing thermal damage to surrounding tissues or nerves caused by polymerization heat release; or is used for improving elastic matching with human bone tissues so as to reduce the risk of stress-related complications. The preparation method of the polymethyl methacrylate bone cement is simple and easy to operate, and can be used for industrial production.

The present invention discloses a bone degreasing method, which relates to the field of oil and fat processing technology. Specifically, it comprises the following steps: S1: placing a human bone in a mixed solution of a degreasing agent and lipase; S2: outputting ultrasonic waves of a preset frequency to the mixed solution while simultaneously controlling the temperature of the mixed solution within a preset temperature range for a predetermined time period, and counting the number of times the predetermined time period has been completed; S3: determining whether the number of times the predetermined time period has been completed is greater than three; if not, repeating steps S1 and S2. The method aims to degrease human bone specimens without polluting the environment or harming the operator.

1. Name of the product in this design: Planer handle. 2. Purpose of this design: To be used in surgical procedures in conjunction with planers or drills to treat human bone and / or soft tissues. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

1. Name of the product in this design: Bone Carving Knife. 2. Purpose of this design: This design is used for human bone repair in surgical procedures. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The application discloses a kind of biomimetic Voronoi-nickel titanium-hydrogel heterostructure implants and preparation method thereof, it is related to bone implant technical field, draw lessons from the structural concept of human bone trabecula, complete the preparation of Voronoi porous structure construction and biomimetic Voronoi-nickel titanium skeleton by innovative design method, again with the biomimetic Voronoi-nickel titanium skeleton as base, adopt drying gel method to prepare biomimetic Voronoi-nickel titanium-hydrogel heterostructure implant.The implant integrates the mechanical advantages of high strength, low modulus of nickel titanium alloy and the structural characteristics of high connectivity, high specific surface area of biomimetic Voronoi porous structure, effectively makes up the short board of hydrogel bearing weakness, while hydrogel has buffering energy absorption function, can realize the multi-functional time sequence release of antibacterial, anti-inflammatory, bone regeneration promotion, adapt to the needs of each stage of bone repair.

The application relates to a design method of a layered porous structure of an acetabular cup and the acetabular cup, and the method comprises the following steps: modeling a plurality of rhombohedrons, so that the pore diameter is 500-1200 mu m and the porosity is 60%-90%; generating a cubic array from the rhombohedrons, introducing a simulation calculation software, and performing compression finite element simulation on the cubic array to obtain the compression strength and the elastic modulus of the cubic array; selecting a cubic array meeting the human bone performance, arraying the rhombohedron with the largest pore diameter in the cubic array to obtain an outer porous coating area capable of accommodating the acetabular cup; selecting the rhombohedron with the largest porosity to obtain an inner porous coating area capable of accommodating the acetabular cup; and then performing a Boolean operation on the two array bodies and the outer porous coating area and the inner porous coating area of the acetabular cup respectively to obtain an intersection, so that the layered porous structure of the acetabular cup is finally obtained. The acetabular cup obtained by the method can provide stability after implantation.

This invention discloses a method for preparing a 3D-printed hydrogel scaffold for cartilage repair, comprising: providing methacrylamide chitosan; providing 2-([1,1-biphenyl]-4-ylcarbamoyl)benzoic acid@polylactic acid-glycolic acid copolymer microspheres; obtaining a 3D-printed bio-ink for cartilage repair using methacrylamide chitosan, 2-([1,1-biphenyl]-4-ylcarbamoyl)benzoic acid@polylactic acid-glycolic acid copolymer microspheres, recombinant collagen CF-1552, and lithium magnesium silicate as main raw materials; and obtaining a 3D-printed bio-ink for cartilage repair using the 3D-printed bio-ink for cartilage repair as a raw material to obtain a 3D-printed hydrogel scaffold for cartilage repair. This 3D-printed hydrogel scaffold has advantages such as antibacterial properties and the ability to promote the differentiation of human bone marrow mesenchymal stem cells (hBMSCs) into chondrocytes, and can be used for cartilage repair, potentially bringing new curative opportunities for cartilage injury diseases.

The application discloses a human variable cross-section bone thickness detection method and system based on ultrasonic guided waves, the system derives a human cortical bone dispersion curve through an anisotropic model, obtains an inverted cortical bone thickness distribution rule by using the dispersion curve, and further obtains a cortical bone two-dimensional thickness distribution image, and the system has no radiation hazard to patients, is low in cost, high in real-time performance, wide in application range, and convenient and fast in obtaining bone thickness measurement results, and takes into account the uneven human bone thickness distribution, and has important value in practice.

The invention discloses a model construction method of a gradient random porous structure of a simulated bone trabecula, a white calendite piezoelectric bone scaffold and a preparation method of the white calendite piezoelectric bone scaffold, and the model construction method provided by the invention is a design method based on a Thiessen polygon porous structure with seed point release gradient change and volume scaling coefficient linear gradient change. In the body center scaling process, interpolation calculation is conducted on scaling coefficients from the axis to the outermost end in the cylindrical domain in the radial direction, and therefore the model of the stochastic gradient porous structure with the pore diameter decreasing from inside to outside in the radial direction and the pore edge diameter increasing from inside to outside in the radial direction is finally formed, by designing the formula and process parameters of the white calcium stone ceramic slurry, the possible problems of over-curing, cracking and the like are avoided, and the white calcium stone piezoelectric ceramic bone scaffold with excellent bonding performance is prepared by adopting a 3D printing photocuring printing technology.

The application discloses a functional high-collagen-peptide chicken egg feed additive and a preparation method thereof, relates to the technical field of laying hen feed, and raw materials of the feed additive and weight proportions of the raw materials are as follows: 1 part of arosa chinensis extract, 2 parts of origanum majorana raw powder, 1 part of artemisia leaf raw powder and 7-11 parts of collagen peptide; the feed additive formed by mixing the arosa chinensis extract, the origanum majorana raw powder, the artemisia leaf raw powder and the collagen peptide can effectively improve the Haff index of the chicken egg, the proportion of thick egg white, the viscosity and the eggshell quality in a short period of time and prolongs the egg product preservation period; the content of the collagen peptide in the chicken egg is effectively improved in a short period of time, the nutritional value of the chicken egg is improved, the method of supplementing the collagen peptide by eating the chicken egg plays a promoting role on human bone health, and the collagen peptide is supplemented by using egg white as a mask, so that the beauty function of repairing skin damage and preventing pigment deposition is realized.

This invention provides a PET image attenuation correction method, apparatus, and device, comprising: acquiring an unattenuated PET image and inputting it into a first generative adversarial network (GAN) to output a predicted human tissue distribution map; inputting the predicted human tissue distribution map and the unattenuated PET image into a second GAN cascaded with the first GAN to output a corresponding virtual CT image; and using the virtual CT image to perform attenuation correction on the unattenuated PET image to obtain an attenuated PET image. The human bone tissue enhancement generation framework constructed based on the GAN in this application exhibits significantly richer skeletal structures in CT images generated from NAC-PET images; furthermore, the CT images generated based on the human bone tissue enhancement generation framework constructed in this application achieve better results in terms of grayscale similarity and tissue consistency, thereby improving the accuracy of PET attenuation correction.

The invention belongs to the technical field of tissue engineering, and particularly relates to a bio-ink system for osteochondral repair as well as a preparation method and application of the bio-ink system. The system comprises first bio-ink and second bio-ink which are respectively used for simulating cartilage and bone tissue. The first biological ink is prepared from methacrylic acid gelatin, acellular extracellular matrix powder, aldehyde modified natural polysaccharide, a photoinitiator and a transforming growth factor; the second biological ink is prepared from methacrylic acid gelatin, acellular extracellular matrix powder, nano-hydroxyapatite, aldehyde modified natural polysaccharide, a photoinitiator and human bone morphogenetic protein BMP-2. The bio-ink system can guarantee smooth extrusion and interlayer fusion in the printing process; the constructed bionic microenvironment and the affinity effect of the bionic microenvironment on growth factors are suitable for 3D printing construction of the osteochondral integrated bionic scaffold and have good clinical transformation potential.

The application discloses a kind of biological composite material for regulating magnesium ion release by surface layer channel and preparation thereof, belong to the technical field of biomedical materials.The surface layer of the composite material is porous zinc alloy, and the core is medical magnesium alloy.The preparation method includes first using atmosphere smelting combined with nested extrusion process to obtain zinc-magnesium composite bar, then preparing porous zinc alloy surface layer on the surface of the composite bar by laser drilling.The application realizes the controllable degradation of the overall material and the controllable release of magnesium ions.The surface layer zinc alloy slows down the degradation rate of the core magnesium alloy, and the surface layer regulates the magnesium ion release dose through channel size and distribution, i.e., it achieves the use of magnesium ions to promote the bone effect and promote the initial osteogenesis of the composite implant material, and through the volume ratio design of the surface layer zinc alloy and the core magnesium alloy, the degradation rate is regulated to match the bone tissue healing process.The material has moderate mechanical properties, and the elastic modulus is similar to that of human bone.The preparation process is simple, precise, and suitable for mass production.

The utility model discloses a humerus handle beneficial to large and small tubercle reconstruction, which comprises a humerus prosthesis handle, a cover plate and a fixing screw, a screw hole is arranged on the humerus prosthesis handle, a joint surface is fixed on the humerus prosthesis handle, the joint surface is matched with a cambered surface joint head, and the cover plate is fixed on the cover plate. The humerus prosthesis handle is mutually fixed with a human body bone block through the cover plate and the fixing screw. According to the humerus handle beneficial to large and small tubercle reconstruction, the overall operation is simple, a doctor does not need to conceal a suture binding mode and a mechanical structure when a patient moves later, compared with a traditional suture binding mode, the risk that bone fragments are separated from the binding position is high, the design has no risk, fixation is firm, the humerus prosthesis handle is made of a titanium alloy material, and the use is convenient. The screw and the cover plate are also made of titanium alloy materials, biocompatibility is guaranteed, meanwhile, strength is achieved, the cover plate and the screw are in spherical connection, the device can better adapt to the shape of a bone block, and the adaptability of the device is improved.

The application discloses a polymethyl methacrylate bone cement as well as a preparation method and application thereof, and belongs to the technical field of bone cement. The polymethyl methacrylate bone cement is constructed with a rigid-elastic composite structure by introducing polyurethane and / or polycaprolactone, and realizes the effects of elastic modulus regulation and polymerization heat release inhibition; the obtained polymethyl methacrylate bone cement has an elastic modulus of 0.6 GPa to 2 GPa, which is much lower than that of a traditional product; the polymerization peak temperature can be as low as 47.8 DEG C, which is more than 50 DEG C lower than that of the traditional bone cement; meanwhile, the compressive strength can be kept not lower than 70 MPa, which fully meets the requirements of an industry standard. The preparation method of the polymethyl methacrylate bone cement is simple and can be used for industrial production; the prepared polymethyl methacrylate bone cement can significantly reduce the thermal damage of polymerization heat release to surrounding tissues, improve the elastic matching with human bone tissues, and is suitable for clinical bone repair scenes such as vertebroplasty.

This invention discloses a method for preparing and using a long-acting antitumor organic and inorganic bone binder, which is prepared by polymerization, blending, and freeze-drying of porous calcium phosphate and antioxidant-grafted Tremella fuciformis polysaccharide hydrogel. The porous calcium phosphate is prepared by controlling its porous structure and composition to achieve degradation, thereby slowly releasing calcium ions, improving osteogenic properties, and achieving high bonding strength with human bone at the postoperative bone tumor defect site. Simultaneously, leveraging the high bonding strength and long-acting antitumor properties of the Tremella fuciformis polysaccharide hydrogel grafted with one or two antioxidants such as ascorbic acid, tea polyphenols, flavonoids, and tocopherols, the porous calcium phosphate and antioxidant-grafted Tremella fuciformis polysaccharide hydrogel are combined to form a covalently cross-linked network structure, further improving the bonding strength of the bone binder, promoting osteogenic properties with host bone tissue, and providing a long-lasting antitumor cycle.

This utility model discloses a skull base defect repair device with adjustable function, including a card body. The front side of the card body is convex, and the rear side is concave. A clamping part is provided at the center of the front side of the convex side. The clamping part is arranged in an "I" shape. With the card body and clamping part provided, compared with other rigid reconstruction materials, this invention uses β-tricalcium phosphate material that can absorb human bone. It is made by mechanical processing or 3D printing technology. It has good biodegradability, biocompatibility, and non-toxicity. It can be used as an ideal bone substitute material for rigid reconstruction. In addition, this application also has the advantages of being ultra-thin, having stable clamping and good sealing effect, which can greatly reduce the occurrence of complications such as rejection reaction, postoperative cerebrospinal fluid leakage, postoperative brain tissue protrusion, and intracranial infection.

The present invention provides an artificial skeletal joint and a preparation method thereof, wherein the artificial skeletal joint comprises a skeletal joint body, a first micro-arc oxidation film layer, and a second micro-arc oxidation film layer; the skeletal joint body is made of a titanium alloy; the first micro-arc oxidation film layer is disposed on the joint movable surface of the skeletal joint body, and the second micro-arc oxidation film layer is disposed on the human bone contact surface of the skeletal joint body. The above-mentioned artificial skeletal joint adopts a double-surface treatment method to modify the surface of the titanium alloy skeletal joint body, and performs a micro-arc oxidation process strengthening treatment on the joint movable surface to prepare a first micro-arc oxidation film layer with high hardness, high elastic modulus, and low friction coefficient. The human bone contact surface is subjected to a micro-arc oxidation roughening treatment to prepare a second micro-arc oxidation film layer with low elastic modulus and biocompatibility, thereby meeting the requirements of different characteristics of different positions of the artificial skeletal joint and improving wear and stress shielding of bone tissue.