857 results about "Human bone" patented technology

A suture anchor having a conical surface and a bore in which an end of an insertion tool is inserted. The insertion end of the insertion tool is made of material having elastic properties. The bore and base of the suture anchor are angled with respect to the central axis of the suture anchor and preferably are parallel to each other. During insertion, the suture anchor is reoriented to fit into the hole, thereby bending the elastic end of the insertion tool. When the suture anchor is within cancellous bone tissue, the elastic properties of the insertion tool deploys the suture anchor to an orientation in which the suture anchor cannot fit through the bone hole, thereby firmly anchoring the suture anchor in the human bone.

The present invention discloses a structural and mechanical model and modeling methods for human bone based on bone's hierarchical structure and on its hierarchical mechanical behavior. The model allows for the assessment of bone deformations, computation of strains and stresses due to the specific forces acting on bone during function, and contemplates forces that do or do not cause viscous effects and forces that cause either elastic or plastic bone deformation.

A dietary supplement for benefitting human bone health includes a calcium source, a source of vitamin D activity, and an osteoblast stimulant. A preferred calcium source is microcrystalline hydroxyapatite, which also contains protein (mostly collagen), phosphorus, fat, and other minerals. A preferred source of vitamin D activity is cholecalciferol, and a preferred osteoblast stimulant is ipriflavone. In addition to these basic ingredients, the composition can further include various other minerals known to occur in bone, vitamin C, and glucosamine sulfate, all of which exert beneficial effects on growth and maintenance of healthy bone. A method for benefitting human bone health involves administering a daily regimen of the dietary supplement.

Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts joined at nodes. Implants are optimized for the expected stress applied at the bone structure site.

In various embodiments, an implant for interfacing with a bone structure includes a web structure including a space truss. The space truss includes two or more planar truss units having a plurality of struts joined at nodes and the web structure is configured to interface with human bone tissue. In some embodiments, a method is provided that includes accessing an intersomatic space and inserting an implant into the intersomatic space. The implant includes a web structure including a space truss. The space truss includes two or more planar truss units having a plurality of struts joined at nodes and the web structure is configured to interface with human bone tissue.

The present invention provides methods of improving the osteogenic and/or chondrogenic activity of a bone matrix, e.g., a dermineralized bone matrix (DBM), by exposing the bone matrix to one or more treatments or conditions. In preferred embodiments the bone matrix is derived from human bone. The treatment or condition may alter the structure of the bone matrix and/or cleave one or more specific proteins. Cleavage may generate peptides or protein fragments that have osteoinductive, osteogenic, or chondrogenic activity. Preferred treatments include collagenase and various other proteases. The invention further provides improved bone and cartilage matrix compositions that have been prepared according to the inventive methods and methods of treatment using the compositions. The invention further provides methods of preparing, testing, and using the improved bone matrix compositions. Ona assay comprises exposing relatively undifferentiated mesenchymal cells to a bone matrix composition and measuring expression of a marker characteristic of osteoblast or chondrocyte lineage(s). Increased expression of the marker relative to the level of the marker in cells that have been exposed to a control matrix (e.g., an inactivated or untreated matrix) indicates that the treatment or condition increased the osteogenic and/or chondrogenic activity of the bone matrix. Suitable cells include C2C12 cells. A suitable marker is alkaline phosphatase. The inventive methods increase the osteogenic and/or chondrogenic activity of human DBM when tested using this assay system.

An implant device for spinal interbody fusion surgery has a shape substantially similar to a human excavated disc space, and includes a first modular end section, at least one modular middle section disposed adjacent to the first modular end section, a second modular end section disposed adjacent to the modular middle section and wherein when the first end section, the middle section and the second end section are placed adjacent to each other, the implant device has a shape with is substantially oval, viewed from top, and a cross section which is bi-convex. The preferred embodiment of the implant device is manufactured from human bone material that has been formed into the shape of the modular components. Alternative embodiments are manufactured from non-human material such as hydrooxyapetite, ceramics, coral and other biodegradable material. Non-resorptable plastic and metal can be used as internal structural members of the implant modules.

The invention relates to a pore network model (PNM)-based bionic bone scaffold constructing method. The method comprises the following steps of: acquiring a cross section image of microscopic three-dimensional micropore structural information and three-dimensional space position density information of a human bone by a micro computed tomography (Micro-CT) technology; performing threshold value processing to acquire binarized image data; extracting a spongy bone part, and measuring by using Mimics software to acquire porosity, penetration rate, aperture and the like; programming PNM bone scaffold parameters according to a PNM principle by using the acquired bone overall dimension data and internal size data; acquiring a generating program of the bone scaffold by using a programming tool C++ and OPENGRIP language programming; generating a three-dimensional model of the PNM bionic bone scaffold by using a Unigraphics (UG) secondary development platform; and finally leading the PNM bionic bone scaffold into the Mimics software to verify the parameters, such as the aperture, the penetration rate and the like of the PNM bionic bone scaffold. The bone scaffold well imitates a natural bone, and has high performance similar to that of the natural bone; and a good porous structure and the high penetration rate are favorable for differentiation and flowing of bone derived cells.

An orthopedic prosthetic implant comprises a metal alloy stem element (13, 63, 113), which has one end portion (19, 69, 119) constructed to reside in the medullary cavity of a bone and an integral connector (23, 73, 123) at the opposite end to which crystalline brittle head (17, 67, 117), preferably made of pyrocarbon-coated graphite, is joined. The head interfaces with human bone, and its effective joinder to the stem element is achieved through a polymeric insert (15, 65, 115) of proportional shape and design which has selected elastic properties. The design and material of the polymeric insert allow it to be securely received within an interior cavity (35, 77, 131) of the pyrocarbon-coated graphite head and mated to the stem connector in an either rigidly or bi-polar arrangement. The method of joinder allows the construction of composite implants that utilize the most desirable properties of metallic and brittle crystalline materials.

The invention discloses an audio processing method for a bone conduction headset, the bone conduction headset and an audio playback device based on the bone conduction headset. The bone conduction headset comprises a human bone and tissue model modeling module, a digital pre-corrector, a delay estimation unit, a digital-to-analog converter, an analog-digital converter, a first low-pass filter, a second low-pass filter, an audio amplifier, an audio driving amplifier, at least one bone conduction microphone, and at least one bone conduction vibrator. In the method, human bone and tissue attenuation effect information of different users is detected in real time; a compensating transfer function is generated based on the attenuation effect information; and an input audio signal is subjected to digital pre-correction via the compensating transfer function, and then the processed input audio signal is transmitted in human bones and tissues. Through adoption of the method, a problem that experience of the bone conduction headset is different caused by different tissue thickness of the different users is solved.

The invention discloses a method for manufacturing a navigation template of human bone surgery and a female die thereof. The method comprises the following steps of: a, acquiring raw data of a patient bone, and establishing a three-dimensional model on a computer; b, analyzing the three-dimensional model, extracting a bone curve image near a surgical screw inlet part, and designing a screw positioning rod; c, establishing a reverse template fitted with a bone curve near the surgical screw inlet part to make the screw positioning rod matched with the reverse template through reverse engineering software, establishing a three-dimensional model of the female die of the surgical navigation template, and manufacturing a physical model of the female die; and d, pouring biomedical materials into the physical model of the female die to make the bottom three-dimensional shape of the biomedical material model fitted and consistent with the bone curve near the surgical screw inlet part, and hardening to form the biocompatible navigation template of human bone surgery. The biocompatible navigation template of the human bone surgery manufactured by the invention makes the surgery safer and achieves better effect.

A glenoid prosthesis for use in total shoulder arthroplasty. The glenoid prosthesis has a concave articulating plate that can interact with the humeral component of an artificial shoulder joint, and a backing for connecting and bonding the prosthesis to the human scapula. The backing of the glenoid prosthesis can be made using hydroxyapatite, which forms a bond with human bone. The backing can further include means for connecting, such as pegs or a keel, to facilitate the connection of the glenoid prosthesis with the scapula.

The invention discloses a composite frame of multi-aldehyde sodium alginate cross-linked polyethylene / chitosan for bone or cartilage repair and treatment, as well as preparation and application of the material of the framework. The framework is made from Calcium polyphosphate, chitosan and multi-aldehyde sodium alginate. As organic matrix multi-aldehyde sodium alginate cross-linked chitosan derived from nature which is the main component of the composite frameworks of the invention, therefore the composite framework is safe and non-toxic, has good biocompatibility and biodegradability, and cell identificaton signal existed on the surface provides physical support and the best chemical environment for bone or cartilage regeneration and reconstruction, the network structure makes the mechanical properties improved greatly. In addition, the components of the inorganic strengthened calcium polyphosphate are consistent with those of human bone tissue, has the property of activity which promotes bone or cartilage growth and the controllable degradation. The composite of the invention can be used as defect repair of bone or cartilage and tissue engineering, drug delivery carrier.

Compositions and methods for isolating and expanding human mesenchymal stem/progenitor cells through multiple passages in defined serum-free environments are provided. The culture media compositions includes a basal medium supplemented with a nutrient mixture such as Ham's F12 nutrient mixture, glutamine, buffer solutions such as sodium bicarbonate and hepes, serum albumin, a lipid mixture, insulin, transferrin, putrescine, progesterone, fetuin, hydrocortisone, ascorbic acid or its analogues such as ascorbic acid-2-phosphate, fibroblast growth factor and transforming growth factor β, and are free of serum or other undefined serum substitutes such as platelet lysate. Methods employing these compositions and protein-coated surfaces for the isolation of mesenchymal stem/progenitor cells from human bone marrow and other tissues such as adipose tissue are also provided. Finally, methods are also provided for serially expanding these cells through multiple passages without losing mesenchymal stem cell-specific proliferative, phenotypical and differentiation characteristics.

The invention discloses a preparation method of a bio-ceramic coating titanium-wire sintering porous titanium artificial bone, belonging to the biomedical engineering field. In the invention, a three-dimensional weaving method is utilized, a titanium metal fiber wire is constructed into a controllable structure model, a random structure model and a bionic structure model which can stimulate the bone trabecula and principal stress line of a human bone, and then is prepared into the porous titanium artificial bone through prepressing molding and vacuum sintering, after that, a sol-gel method is utilized to manufacture a gradient coating or a complex coating on the surface of the porous titanium artificial bone, so that the gradient coating transiting from titanium dioxide to bio-ceramics or the bio-ceramics-titanium dioxide complex coating is formed on the surface of the porous titanium artificial bone to obtain the bio-ceramic coating titanium-wire sintering porous titanium artificial bone. The preparation method not only can protect the titanium metal skeleton and prevent titanium ions from dissociating to enter a human body, but also can ensure that the titanium metal skeleton the surface of which is coated with the bio-ceramics has the biological characteristics, therefore, the bio-ceramic coating titanium-wire sintering porous titanium artificial bone can be applied to repairing clinical segmental defect of long bones.

The invention relates to the field of biotechnology and mainly relates to a use of an early-generation human umbilical cord mesenchymal stem cell exosome in promotion of human bone mesenchymal stem cell growth. The use method is a method for promoting bone mesenchymal stem cell growth. The invention also relates to an extraction method of a human umbilical cord mesenchymal stem cell exosome. The early-generation human umbilical cord mesenchymal stem cell exosome and human bone mesenchymal stem cells are co-cultured so that human bone mesenchymal stem cell growth is obviously promoted, cell doubling time is shortened and a ratio of an S period in a cell period is increased.