861 results about "Human bone" patented technology

A sterile suture anchor comprising a body with a distal end, tapered planar side walls and a dome shaped proximal end, a cross section of said body forming a triangular shape with at least one rounded end; and a suture aperture transversely cut through the body being dimensioned to hold at least one suture. An insertion tool for inserting the suture anchor through a substantially cylindrical bore hole in a live human bone and causing the suture anchor to be anchored comprises a handle, a hollow tube secured to the handle and a driver rod slidably mounted in the tube. The driver rod has a distal end defining an angled cam which engages a suture anchor mounted in said tube and rotates the suture anchor into a desired position for insertion into human tissue. A finger driver assembly is mounted on the handle and is secured to the driver and so that movement of the finger driver assembly causes the driver rod to be moved within the hollow tube causing the driver rod cam end to engage the suture anchor and turn the suture anchor in a predetermined orientation for anchoring in the bore hole.

A suture anchor having a conical surface and a bore in which an end of an insertion tool is inserted. The insertion end of the insertion tool is made of material having elastic properties. The bore and base of the suture anchor are angled with respect to the central axis of the suture anchor and preferably are parallel to each other. During insertion, the suture anchor is reoriented to fit into the hole, thereby bending the elastic end of the insertion tool. When the suture anchor is within cancellous bone tissue, the elastic properties of the insertion tool deploys the suture anchor to an orientation in which the suture anchor cannot fit through the bone hole, thereby firmly anchoring the suture anchor in the human bone.

The present invention discloses a structural and mechanical model and modeling methods for human bone based on bone's hierarchical structure and on its hierarchical mechanical behavior. The model allows for the assessment of bone deformations, computation of strains and stresses due to the specific forces acting on bone during function, and contemplates forces that do or do not cause viscous effects and forces that cause either elastic or plastic bone deformation.

A human bone substitutional implant comprises a main body and a push body. The main body is a hollow cylinder with a thread portion or a ratchet portion disposed on its outer wall. The thread portion or the ratchet portion has at least a slit dividing it into four equal parts. An inner thread is disposed on the inner wall of the thread portion or the ratchet portion. An outer thread is disposed on the outer surface of the push body and corresponds to the inner thread. The push body and the main body are joined together via screw connection of the outer thread and the inner thread. Because the main body has a conical passage therein, the main body will be held open a certain angle to support and enhance a fractured bone of the human body when the push body is axially pushed into the main body.

A dietary supplement for benefitting human bone health includes a calcium source, a source of vitamin D activity, and an osteoblast stimulant. A preferred calcium source is microcrystalline hydroxyapatite, which also contains protein (mostly collagen), phosphorus, fat, and other minerals. A preferred source of vitamin D activity is cholecalciferol, and a preferred osteoblast stimulant is ipriflavone. In addition to these basic ingredients, the composition can further include various other minerals known to occur in bone, vitamin C, and glucosamine sulfate, all of which exert beneficial effects on growth and maintenance of healthy bone. A method for benefitting human bone health involves administering a daily regimen of the dietary supplement.

Various embodiments of implant systems and related apparatus, and methods of operating the same are described herein. In various embodiments, an implant for interfacing with a bone structure includes a web structure, including a space truss, configured to interface with human bone tissue. The space truss includes two or more planar truss units having a plurality of struts joined at nodes. Implants are optimized for the expected stress applied at the bone structure site.

In various embodiments, an implant for interfacing with a bone structure includes a web structure including a space truss. The space truss includes two or more planar truss units having a plurality of struts joined at nodes and the web structure is configured to interface with human bone tissue. In some embodiments, a method is provided that includes accessing an intersomatic space and inserting an implant into the intersomatic space. The implant includes a web structure including a space truss. The space truss includes two or more planar truss units having a plurality of struts joined at nodes and the web structure is configured to interface with human bone tissue.

The present invention is directed to a hybrid bone fixation element including a threaded proximal cortical bone contacting portion for threadably engaging the cortical portion of a human bone and a non-threaded expandable distal cancellous portion for engaging the cancellous portion of the human bone. The hybrid bone fixation element can be used, for example, as a pedicle screw, a bone screw or in any other type of bone fixation application.

The present invention provides methods of improving the osteogenic and / or chondrogenic activity of a bone matrix, e.g., a dermineralized bone matrix (DBM), by exposing the bone matrix to one or more treatments or conditions. In preferred embodiments the bone matrix is derived from human bone. The treatment or condition may alter the structure of the bone matrix and / or cleave one or more specific proteins. Cleavage may generate peptides or protein fragments that have osteoinductive, osteogenic, or chondrogenic activity. Preferred treatments include collagenase and various other proteases. The invention further provides improved bone and cartilage matrix compositions that have been prepared according to the inventive methods and methods of treatment using the compositions. The invention further provides methods of preparing, testing, and using the improved bone matrix compositions. Ona assay comprises exposing relatively undifferentiated mesenchymal cells to a bone matrix composition and measuring expression of a marker characteristic of osteoblast or chondrocyte lineage(s). Increased expression of the marker relative to the level of the marker in cells that have been exposed to a control matrix (e.g., an inactivated or untreated matrix) indicates that the treatment or condition increased the osteogenic and / or chondrogenic activity of the bone matrix. Suitable cells include C2C12 cells. A suitable marker is alkaline phosphatase. The inventive methods increase the osteogenic and / or chondrogenic activity of human DBM when tested using this assay system.

A bone plate system is provided which maintains intervertebral spacing and stability of a spine. In an embodiment, a bone plate system may include a base plate with an opening through which the fastener may be positioned to allow the fastener to be inserted into a human bone at a desired angle relative to the plate. Some embodiments of a bone plate system may include a base plate and an extender plate. An extender plate may be coupled to a base plate while the base plate is coupled to the bone.

An implant device for spinal interbody fusion surgery has a shape substantially similar to a human excavated disc space, and includes a first modular end section, at least one modular middle section disposed adjacent to the first modular end section, a second modular end section disposed adjacent to the modular middle section and wherein when the first end section, the middle section and the second end section are placed adjacent to each other, the implant device has a shape with is substantially oval, viewed from top, and a cross section which is bi-convex. The preferred embodiment of the implant device is manufactured from human bone material that has been formed into the shape of the modular components. Alternative embodiments are manufactured from non-human material such as hydrooxyapetite, ceramics, coral and other biodegradable material. Non-resorptable plastic and metal can be used as internal structural members of the implant modules.

The present invention discloses a structural and mechanical model and modeling methods for human bone based on bone's hierarchical structure and on its hierarchical mechanical behavior. The model allows for the assessment of bone deformations, computation of strains and stresses due to the specific forces acting on bone during function, and contemplates forces that do or do not cause viscous effects and forces that cause either elastic or plastic bone deformations.

In various embodiments, an implant for interfacing with a bone structure includes a web structure including a space truss. The space truss includes two or more planar truss units having a plurality of struts joined at nodes and the web structure is configured to interface with human bone tissue. In some embodiments, a method is provided that includes accessing an intersomatic space and inserting an implant into the intersomatic space. The implant includes a web structure including a space truss. The space truss includes two or more planar truss units having a plurality of struts joined at nodes and the web structure is configured to interface with human bone tissue.

Ultrasound measurement of bone quality using nonlinear analysis in combination with or alternatively using shear waves provide improved information about human bone conditions. Surface waves also provide a novel method to estimate shear wave velocity.

The invention relates to a pore network model (PNM)-based bionic bone scaffold constructing method. The method comprises the following steps of: acquiring a cross section image of microscopic three-dimensional micropore structural information and three-dimensional space position density information of a human bone by a micro computed tomography (Micro-CT) technology; performing threshold value processing to acquire binarized image data; extracting a spongy bone part, and measuring by using Mimics software to acquire porosity, penetration rate, aperture and the like; programming PNM bone scaffold parameters according to a PNM principle by using the acquired bone overall dimension data and internal size data; acquiring a generating program of the bone scaffold by using a programming tool C++ and OPENGRIP language programming; generating a three-dimensional model of the PNM bionic bone scaffold by using a Unigraphics (UG) secondary development platform; and finally leading the PNM bionic bone scaffold into the Mimics software to verify the parameters, such as the aperture, the penetration rate and the like of the PNM bionic bone scaffold. The bone scaffold well imitates a natural bone, and has high performance similar to that of the natural bone; and a good porous structure and the high penetration rate are favorable for differentiation and flowing of bone derived cells.

An orthopedic prosthetic implant comprises a metal alloy stem element (13, 63, 113), which has one end portion (19, 69, 119) constructed to reside in the medullary cavity of a bone and an integral connector (23, 73, 123) at the opposite end to which crystalline brittle head (17, 67, 117), preferably made of pyrocarbon-coated graphite, is joined. The head interfaces with human bone, and its effective joinder to the stem element is achieved through a polymeric insert (15, 65, 115) of proportional shape and design which has selected elastic properties. The design and material of the polymeric insert allow it to be securely received within an interior cavity (35, 77, 131) of the pyrocarbon-coated graphite head and mated to the stem connector in an either rigidly or bi-polar arrangement. The method of joinder allows the construction of composite implants that utilize the most desirable properties of metallic and brittle crystalline materials.

The invention discloses an audio processing method for a bone conduction headset, the bone conduction headset and an audio playback device based on the bone conduction headset. The bone conduction headset comprises a human bone and tissue model modeling module, a digital pre-corrector, a delay estimation unit, a digital-to-analog converter, an analog-digital converter, a first low-pass filter, a second low-pass filter, an audio amplifier, an audio driving amplifier, at least one bone conduction microphone, and at least one bone conduction vibrator. In the method, human bone and tissue attenuation effect information of different users is detected in real time; a compensating transfer function is generated based on the attenuation effect information; and an input audio signal is subjected to digital pre-correction via the compensating transfer function, and then the processed input audio signal is transmitted in human bones and tissues. Through adoption of the method, a problem that experience of the bone conduction headset is different caused by different tissue thickness of the different users is solved.

A suture anchor and kit for anchoring a suture member to human bone in an interference fit. A suture anchor includes a threaded portion and has a head at the proximal end thereof, the head being generally circular. A tip is located at a distal end of the shank. The shank is at least partially threaded and includes walls defining a reel portion. The shank also includes walls for engaging a suture, the walls for engaging the suture typically adjacent walls defining the reel portion. The head typically includes walls for engaging a drive tool. The kit includes a drive tool for rotating the suture anchor when a suture member is engaged with the walls for engaging the suture such that rotation of the anchor causes the suture material to wrap around the reel portion of the shank.

The invention discloses a method for manufacturing a navigation template of human bone surgery and a female die thereof. The method comprises the following steps of: a, acquiring raw data of a patient bone, and establishing a three-dimensional model on a computer; b, analyzing the three-dimensional model, extracting a bone curve image near a surgical screw inlet part, and designing a screw positioning rod; c, establishing a reverse template fitted with a bone curve near the surgical screw inlet part to make the screw positioning rod matched with the reverse template through reverse engineering software, establishing a three-dimensional model of the female die of the surgical navigation template, and manufacturing a physical model of the female die; and d, pouring biomedical materials into the physical model of the female die to make the bottom three-dimensional shape of the biomedical material model fitted and consistent with the bone curve near the surgical screw inlet part, and hardening to form the biocompatible navigation template of human bone surgery. The biocompatible navigation template of the human bone surgery manufactured by the invention makes the surgery safer and achieves better effect.

A glenoid prosthesis for use in total shoulder arthroplasty. The glenoid prosthesis has a concave articulating plate that can interact with the humeral component of an artificial shoulder joint, and a backing for connecting and bonding the prosthesis to the human scapula. The backing of the glenoid prosthesis can be made using hydroxyapatite, which forms a bond with human bone. The backing can further include means for connecting, such as pegs or a keel, to facilitate the connection of the glenoid prosthesis with the scapula.

The invention discloses a composite frame of multi-aldehyde sodium alginate cross-linked polyethylene / chitosan for bone or cartilage repair and treatment, as well as preparation and application of the material of the framework. The framework is made from Calcium polyphosphate, chitosan and multi-aldehyde sodium alginate. As organic matrix multi-aldehyde sodium alginate cross-linked chitosan derived from nature which is the main component of the composite frameworks of the invention, therefore the composite framework is safe and non-toxic, has good biocompatibility and biodegradability, and cell identificaton signal existed on the surface provides physical support and the best chemical environment for bone or cartilage regeneration and reconstruction, the network structure makes the mechanical properties improved greatly. In addition, the components of the inorganic strengthened calcium polyphosphate are consistent with those of human bone tissue, has the property of activity which promotes bone or cartilage growth and the controllable degradation. The composite of the invention can be used as defect repair of bone or cartilage and tissue engineering, drug delivery carrier.

Compositions and methods for isolating and expanding human mesenchymal stem / progenitor cells through multiple passages in defined serum-free environments are provided. The culture media compositions includes a basal medium supplemented with a nutrient mixture such as Ham's F12 nutrient mixture, glutamine, buffer solutions such as sodium bicarbonate and hepes, serum albumin, a lipid mixture, insulin, transferrin, putrescine, progesterone, fetuin, hydrocortisone, ascorbic acid or its analogues such as ascorbic acid-2-phosphate, fibroblast growth factor and transforming growth factor β, and are free of serum or other undefined serum substitutes such as platelet lysate. Methods employing these compositions and protein-coated surfaces for the isolation of mesenchymal stem / progenitor cells from human bone marrow and other tissues such as adipose tissue are also provided. Finally, methods are also provided for serially expanding these cells through multiple passages without losing mesenchymal stem cell-specific proliferative, phenotypical and differentiation characteristics.

The invention discloses a preparation method of a bio-ceramic coating titanium-wire sintering porous titanium artificial bone, belonging to the biomedical engineering field. In the invention, a three-dimensional weaving method is utilized, a titanium metal fiber wire is constructed into a controllable structure model, a random structure model and a bionic structure model which can stimulate the bone trabecula and principal stress line of a human bone, and then is prepared into the porous titanium artificial bone through prepressing molding and vacuum sintering, after that, a sol-gel method is utilized to manufacture a gradient coating or a complex coating on the surface of the porous titanium artificial bone, so that the gradient coating transiting from titanium dioxide to bio-ceramics or the bio-ceramics-titanium dioxide complex coating is formed on the surface of the porous titanium artificial bone to obtain the bio-ceramic coating titanium-wire sintering porous titanium artificial bone. The preparation method not only can protect the titanium metal skeleton and prevent titanium ions from dissociating to enter a human body, but also can ensure that the titanium metal skeleton the surface of which is coated with the bio-ceramics has the biological characteristics, therefore, the bio-ceramic coating titanium-wire sintering porous titanium artificial bone can be applied to repairing clinical segmental defect of long bones.

The invention relates to the field of biotechnology and mainly relates to a use of an early-generation human umbilical cord mesenchymal stem cell exosome in promotion of human bone mesenchymal stem cell growth. The use method is a method for promoting bone mesenchymal stem cell growth. The invention also relates to an extraction method of a human umbilical cord mesenchymal stem cell exosome. The early-generation human umbilical cord mesenchymal stem cell exosome and human bone mesenchymal stem cells are co-cultured so that human bone mesenchymal stem cell growth is obviously promoted, cell doubling time is shortened and a ratio of an S period in a cell period is increased.

The present invention discloses a structural and mechanical model and modeling methods for human bone based on bone's hierarchical structure and on its hierarchical mechanical behavior. The model allows for the assessment of bone deformations, computation of strains and stresses due to the specific forces acting on bone during function, and contemplates forces that do or do not cause viscous effects and forces that cause either elastic or plastic bone deformation.

Scaffolds made of composite materials and uses thereof in the field of biomedical engineering are disclosed, wherein the composite materials comprise bioactive microparticles that could induce the human bone tissue to regenerate. The scaffolds uses the combination of silicon, calcium, and phosphorus microparticles as bioactive substance that could actively induce the human osteoblasts to proliferate and differentiate, promote the formation and calcification of new bone. Furthermore, the scaffolds employs organic polymer as carrier, takes a three-dimensional structure and external anatomical shape, and exhibits several characteristics compatible with the regeneration of bones and the neogenesis of blood vessels, thereby it could be used safely, economically and effectively for repairing the defect of bone tissue as well as in orthopedic operation of human bone. The present invention also discloses the methods for preparing the scaffolds.