23 results about "Human bone" patented technology

The application discloses a kind of biomimetic Voronoi-nickel titanium-hydrogel heterostructure implants and preparation method thereof, it is related to bone implant technical field, draw lessons from the structural concept of human bone trabecula, complete the preparation of Voronoi porous structure construction and biomimetic Voronoi-nickel titanium skeleton by innovative design method, again with the biomimetic Voronoi-nickel titanium skeleton as base, adopt drying gel method to prepare biomimetic Voronoi-nickel titanium-hydrogel heterostructure implant.The implant integrates the mechanical advantages of high strength, low modulus of nickel titanium alloy and the structural characteristics of high connectivity, high specific surface area of biomimetic Voronoi porous structure, effectively makes up the short board of hydrogel bearing weakness, while hydrogel has buffering energy absorption function, can realize the multi-functional time sequence release of antibacterial, anti-inflammatory, bone regeneration promotion, adapt to the needs of each stage of bone repair.

This invention provides a PET image attenuation correction method, apparatus, and device, comprising: acquiring an unattenuated PET image and inputting it into a first generative adversarial network (GAN) to output a predicted human tissue distribution map; inputting the predicted human tissue distribution map and the unattenuated PET image into a second GAN cascaded with the first GAN to output a corresponding virtual CT image; and using the virtual CT image to perform attenuation correction on the unattenuated PET image to obtain an attenuated PET image. The human bone tissue enhancement generation framework constructed based on the GAN in this application exhibits significantly richer skeletal structures in CT images generated from NAC-PET images; furthermore, the CT images generated based on the human bone tissue enhancement generation framework constructed in this application achieve better results in terms of grayscale similarity and tissue consistency, thereby improving the accuracy of PET attenuation correction.

The application discloses a kind of biological composite material for regulating magnesium ion release by surface layer channel and preparation thereof, belong to the technical field of biomedical materials.The surface layer of the composite material is porous zinc alloy, and the core is medical magnesium alloy.The preparation method includes first using atmosphere smelting combined with nested extrusion process to obtain zinc-magnesium composite bar, then preparing porous zinc alloy surface layer on the surface of the composite bar by laser drilling.The application realizes the controllable degradation of the overall material and the controllable release of magnesium ions.The surface layer zinc alloy slows down the degradation rate of the core magnesium alloy, and the surface layer regulates the magnesium ion release dose through channel size and distribution, i.e., it achieves the use of magnesium ions to promote the bone effect and promote the initial osteogenesis of the composite implant material, and through the volume ratio design of the surface layer zinc alloy and the core magnesium alloy, the degradation rate is regulated to match the bone tissue healing process.The material has moderate mechanical properties, and the elastic modulus is similar to that of human bone.The preparation process is simple, precise, and suitable for mass production.

This invention discloses a method for preparing and using a long-acting antitumor organic and inorganic bone binder, which is prepared by polymerization, blending, and freeze-drying of porous calcium phosphate and antioxidant-grafted Tremella fuciformis polysaccharide hydrogel. The porous calcium phosphate is prepared by controlling its porous structure and composition to achieve degradation, thereby slowly releasing calcium ions, improving osteogenic properties, and achieving high bonding strength with human bone at the postoperative bone tumor defect site. Simultaneously, leveraging the high bonding strength and long-acting antitumor properties of the Tremella fuciformis polysaccharide hydrogel grafted with one or two antioxidants such as ascorbic acid, tea polyphenols, flavonoids, and tocopherols, the porous calcium phosphate and antioxidant-grafted Tremella fuciformis polysaccharide hydrogel are combined to form a covalently cross-linked network structure, further improving the bonding strength of the bone binder, promoting osteogenic properties with host bone tissue, and providing a long-lasting antitumor cycle.

This invention provides a biocompatible β This invention relates to a method for composite modification of titanium alloy surfaces, belonging to the technical field of alloy modification methods. The invention includes applications in medical... β This invention involves introducing bioactive particles onto the surface of a titanium alloy substrate, performing friction stir processing (FSP) on the substrate to introduce bioactive particles and construct a gradient grain structure, and then subjecting the FSP-treated substrate to compressed plasma flow (CPF) treatment to achieve uniform distribution of bioactive particles and construct a topology with an average surface roughness of 3-6 μm suitable for cell growth. The invention precisely controls the amount of bioactive particles introduced and constructs a gradient grain structure through friction stir processing (FSP); simultaneously, compressed plasma flow (CPF) technology achieves uniform distribution of bioactive particles and an ideal surface roughness of 3-6 μm on the titanium alloy surface. Ultimately, this significantly improves the cell adhesion, proliferation capacity, and osteogenic properties of the material surface, solving the technical problem of low integration efficiency of traditional titanium alloy implants with human bone tissue.

This invention discloses a biomimetic helical chiral porous bone repair and bone augmentation scaffold, comprising: a scaffold body composed of an array of multiple lattice units, each lattice unit being a biomimetic trabecular bone cell; the lattice units follow the natural helical arrangement of human bone trabeculae, forming a continuous and interconnected helical channel network within the scaffold body; the lattice units are distributed in a helical gradient along the radial direction of the scaffold body, and the outer wall of the scaffold body has a protruding structure integrally formed with the lattice units. This invention, through the deep coupling of the biomimetic helical chiral structure and cellular fluid dynamics, overcomes the limitations of traditional scaffolds with "static channels," forming a composite flow field of "high-speed guidance - low-speed vortex," effectively solving the problem of "nutrient islands," and significantly improving the survival rate and quality of osteoblasts in the central region.

This invention relates to the field of biomedical materials technology and provides an application of obeticholic acid-exosome nanoparticles in the treatment of hepatic ischemia-reperfusion injury. The obeticholic acid-exosome nanoparticles are prepared by combining exosomes and obeticholic acid using an ultrasonic method, wherein the exosomes are derived from human bone marrow mesenchymal stem cells. The method for preparing the obeticholic acid-exosome nanoparticles is simple and easy to mass-produce. By utilizing exosomes derived from mesenchymal stem cells, the obeticholic acid-exosome nanoparticles improve the drug's targeting in vivo and prolong its circulation time, achieving targeted delivery of obeticholic acid to the liver, thus providing a new targeted therapeutic strategy for hepatic ischemia-reperfusion injury.

The present application relates to the technical field of bioactive glass, in particular to a preparation method and application of strontium-magnesium-doped bioactive glass, on the basis of selecting suitable raw materials, the co-precipitation method is adopted, strontium element is doped, and magnesium oxide is compoundedly added, so that the prepared bioactive glass has regular properties, good dispersible spherical particles, faster and stronger hydroxyapatite formation capacity, faster ion release rate, and can release calcium, phosphorus and silicon ions in simulated body fluid, form more hydroxyapatite, promote the proliferation and stability of bone cells, and stimulate new bone formation. The strontium-magnesium-doped bioactive glass is used in cooperation with mineral trioxide aggregate (MTA), so that cell adhesion, expression of bioactive enzymes, activity of fibroblasts can be promoted, and the strontium-magnesium-doped bioactive glass can be applied to the repair of human bone and dental pulp tissue.

This invention discloses a high-BNIP3-loaded exosome, its preparation method, and its applications, relating to the field of biomedical engineering technology. The high-BNIP3-loaded exosomes are obtained by pre-treating human bone marrow mesenchymal stem cells transfected with a recombinant expression vector carrying the BNIP3 gene, followed by 24 hours of hypoxia at 1% oxygen concentration. The exosomes have a particle size of 40-130 nm and highly express BNIP3 and exosome markers HSP70, CD63, and TSG101. The preparation method includes constructing a pcDNA3.1-BNIP3 recombinant vector, transfecting and screening stable-expressing engineered cells, hypoxia pre-treatment, and purification by gradient centrifugation combined with ultracentrifugation. This invention achieves efficient loading and targeted delivery of BNIP3 through a synergistic strategy of genetic engineering and microenvironment simulation, significantly improving the endocytosis efficiency of nucleus pulposus cells, activating mitophagy, restoring mitochondrial function, and promoting extracellular matrix synthesis. It can be used to prepare drugs for treating intervertebral disc degeneration and has excellent clinical application prospects.

The application discloses a kind of carbon fiber reinforced PPESK medical composite of layer design and preparation method thereof, the present application is impregnated by 10%-20% mass fraction of PPESK / NMP solution using desizing carbon fiber, multi-section gradient temperature drying and water washing or organic solvent purification, obtain low-impurity prepreg tape;Through quasi-isotropic [90° / ±45° / 0°] s layer design, the product obtained by combining 16MPa, 360 ℃ vacuum hot pressing molding realizes the matching with human bone mechanical property, and the bending modulus is adjusted from 143GPa to 32GPa, the bending strength reaches 489MPa, and the interlaminar shear strength is 44.2MPa.The beneficial effects of the present application are that the mechanical properties are precisely controlled through the layer structure, high strength, low modulus and high biological safety are considered, the process is stable and controllable, suitable for orthopedic load-bearing bone implant material, to provide high-performance, high-adaptability new composite material solution for bone implant device.

1. The name of the design product: bone defect prosthesis. 2. The use of the design product: for repairing large bone defects caused by tumor resection, severe trauma, etc. Through surgical implantation in the affected area, it replaces the missing part of the human bone and restores the normal shape and function of the bone. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: Design 1 Solid Drawing 1. 5. Design 1 is designated as the basic design.

This intervertebral fusion device comprises multiple upper lamina with first openings, an integrated lower lamina, and a drive mechanism and lifting mechanism positioned between them. The drive mechanism transmits power via drive rods, meshing bevel gear pairs, and transmission bevel gears. The transmission bevel gears connect to a support column with a track. The transmission rod assembly within the track is equipped with a first spring and a limiting structure. The rod ends have first latches. Third transmission rods on both sides support and push the rising section of the lifting mechanism. The lifting mechanism is fixed to a hollow base of the lower lamina. The base sidewalls have openings and ratchet structures. The internal hollow rising section has multiple through holes and contains a retraction section. The retraction section is equipped with a second spring, a second latch, and a rotatable pawl. The pawl engages with the ratchet of the base to lock the position. During operation, the two sets of latches mesh and drive each other, allowing the retraction section to extend through the openings between the rising section and the upper lamina, directly contacting the human bone.

The application belongs to the technical field of biological medical material production and preparation, and discloses an antibacterial degradable calcium phosphate bone cement and a preparation method thereof. The raw material of the bone cement comprises a solid-phase powder component and a curing liquid, 330-360 muL of the curing liquid is required for every 0.7 g of the solid-phase powder component; the solid-phase powder component comprises tetracalcium phosphate powder, anhydrous dicalcium phosphate powder and strontium-copper-doped beta-tricalcium phosphate powder, the molar ratio of the tetracalcium phosphate powder to the anhydrous dicalcium phosphate powder is 1:1, and the mass ratio of the sum of the mass of the tetracalcium phosphate powder and the mass of the anhydrous dicalcium phosphate powder to the mass of the strontium-copper-doped beta-tricalcium phosphate powder is (7-9):(1-3). The degradation rate of the bone cement is well matched with human bone, and the bone cement has the characteristics of good antibacterial property, good biocompatibility and good mechanical property, and the bone cement product will have good application prospect in the field of orthopedics.

This invention belongs to the field of bone replacement material technology, specifically relating to a porous biodegradable bone replacement scaffold and its preparation method. The porous biodegradable scaffold of this invention consists of pillars, each pillar having an outer shell and a core. The outer shell comprises ZnO, and the core comprises Zn. The porous biodegradable bone replacement scaffold of this invention has a nano- to millimeter-level hierarchical pore structure, which is more similar to the structure of human bone. Furthermore, its degradation performance, antibacterial properties, and biocompatibility are superior to existing biodegradable metallic bone implant materials (zinc and its alloys), which helps promote osteogenic differentiation.

The application discloses a solid beverage for promoting human bone density and a preparation method thereof, and relates to the technical field of solid beverages, and solves the technical problem of low absorption and utilization rate caused by unreasonable allocation ratio of fat-soluble oil components, protein components and polypeptide components in the existing solid beverage; the solid beverage comprises 15-45 parts of fat-soluble oil components, 20-50 parts of plant extract components, 3-12 parts of protein components and polypeptide components, and 4-16 parts of carbohydrate components and dietary fiber components; the problem of difficulty in synergistic fusion of the two types of nutrients is solved, the effect of improving human absorption and utilization rate is achieved, the microencapsulated flaxseed oil microcapsule powder is used as the source of fat-soluble oil, the problem of easy oxidation and rancidity of oil active ingredients is solved, and the effects of maintaining product nutritional stability and prolonging shelf life are achieved. A variety of herbal active ingredient sources are provided, the effect of expanding the formula selection range and meeting the needs of different consumers is achieved.

This invention relates to the field of biomedical materials technology, specifically to a biomedical ceramic and its preparation method, comprising a base phase and a doped phase. The base phase consists of hydroxyapatite and β-tricalcium phosphate, and the doped phase consists of yttrium oxide and silicon oxide. The mass ratio of hydroxyapatite to β-tricalcium phosphate is 10:90 to 70:30. The amount of yttrium oxide added is 0.1 to 4 parts by weight of the total mass of the base phase, and the amount of silicon oxide added is 0.1 to 6 parts by weight of the total mass of the base phase. This invention, through the system design of a two-phase base ceramic and a two-oxide doped system, compensates for the performance defects of single bioceramics at the raw material level, enabling the material to possess stable mechanical properties, a suitable degradation rate, and excellent bioactivity, thus meeting the physiological needs of human bone tissue repair. Furthermore, this invention employs a specific powder pretreatment process, which can effectively remove impurities from the raw materials, improve the purity and mixing uniformity of the raw materials, and lay a good foundation for subsequent molding and sintering.

The application discloses a meat removing device and method for preparing human skeleton specimens in the technical field of skeleton specimen preparation, which comprises a rack and a first container installed on the rack, a second container is horizontally and slidingly matched in the first container, and the first container and the second container form a preparation cavity with an upper opening; a first hole plate is fixedly installed on the first container, a second hole plate is fixedly installed on the second container, and the holes on the first hole plate and the second hole plate are arranged in an up-and-down staggered mode; the second container is connected with a driving component, an output shaft of a hydraulic cylinder is fixedly connected with the second container, a shaft cavity of the hydraulic cylinder is communicated with a power component through a first electromagnetic valve, and the shaft cavity of the hydraulic cylinder is communicated with the preparation cavity through a second electromagnetic valve; a shaftless cavity of the hydraulic cylinder is communicated with the preparation cavity through a third electromagnetic valve, and the shaftless cavity of the hydraulic cylinder is communicated with a fourth electromagnetic valve; and a plurality of elastic elements abutting against a piston are arranged on the side of the hydraulic cylinder away from the output shaft. The application has simple structure and improves the efficiency of skeleton specimen preparation.

This invention belongs to the field of biomedical materials and additive manufacturing technology, and discloses a method for preparing and applying a low-modulus bioactive Ti-Nb alloy porous bone implant. The method includes: three-dimensional design of a porous structure; preparation of a Ti-Nb alloy (80~90:10~20) bicrystalline structure preform using a SLM (Sectional Laser Melting) partitioning scanning strategy; activation via a vacuum / inert atmosphere quenching + sandblasting acid-free etching process; and vacuum plasma spraying of a borosilicate bioglass coating. The product contains a Ti-Nb bicrystalline matrix, a three-dimensional through-porous structure, and a borosilicate coating, with a tensile bond strength ≥30MPa. This invention achieves modulus matching with human bone through compositional control, with no toxic precipitation; partitioning scanning constructs a bicrystalline structure to solve Ti-Nb alloy forming defects; the acid-free etching process preserves the mechanical properties of the matrix; and the coating, along with the bicrystalline and porous structure, synergistically achieves high bonding strength and bidirectional osteogenic effects. Simultaneously, the process is simplified, reducing costs by 20-30%, making it suitable for orthopedic spinal fusion implants.

The application provides application of a Roebel genus-derived outer vesicle in preparation of an inducer for osteogenic differentiation of bone marrow mesenchymal stem cells, and relates to the technical field of biological medicine, wherein the Roebel genus-derived outer vesicle is obtained by using a super-speed centrifugation method, and experiments prove that the Roebel genus-derived outer vesicle has excellent effect of promoting osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs), and can significantly induce up-regulated expression of a marker protein of osteogenic differentiation, and can be used as an inducer for osteogenic differentiation of bone marrow mesenchymal stem cells, and can be applied to preparation of anti-osteoporosis drugs.

This invention discloses a method for preparing low-modulus solid titanium alloys, belonging to the field of materials manufacturing. The method employs electron beam selective melting technology, adjusting the contour parameters, base plate temperature, preheating parameters, and process parameters of the electron beam control system to prepare high-strength solid titanium alloys. <100> Oriented, low-elastic-modulus solid titanium alloys with a modulus of 30-35 GPa are prepared, resulting in alloys with a porosity of less than 1.5%, high dimensional accuracy, and high surface quality. The elastic modulus of the alloy obtained using the method provided in this invention is closer to that of human bone, which can greatly reduce the impact of the "stress shielding" effect. As a non-toxic, novel biomedical titanium alloy, it has good scientific research and application value.