5results about How to "Biologically active" patented technology

This invention discloses a method for preparing and applying plant sulfonated small peptide PSK based on synthetic biology, belonging to the field of biotechnology. Based on the design concept of synthetic biology, this invention constructs an orthogonal synthetic system composed of genetic code expansion technology and SUMO fusion protease digestion technology. A specific PSK dotted vector and a pUltra-sY vector are co-transformed into *E. coli* to construct a genetically engineered strain. The sulfonated small peptide PSK precursor is expressed in this genetically engineered strain, and mature plant sulfonated small peptide PSK is obtained through specific hydrolysis by SUMO protease. This method significantly improves the synthesis efficiency and purity of sulfonated small peptides and has broad application prospects in agricultural production and biotechnology.

The invention discloses a preparation method of alkyl-substituted polyfluorinated aromatic hydrocarbon based on Hanus ester, and belongs to the field of organic synthesis. The invention solves the problems that the existing polyfluoroaryl substituted alkane synthesis substrate has large range limitation, needs metal catalysis, and needs harsh reaction conditions such as high temperature, no water, no oxygen and the like. The method comprises the following steps: uniformly mixing polyfluorinated aromatic hydrocarbon, alkyl-substituted Hanus ester, an Ir (dFCF3ppy) dtbpyPF6 photocatalyst, anhydrous potassium carbonate and an organic solvent, and then carrying out blue illumination reaction. The method is used for preparing the alkyl-substituted polyfluorinated aromatic hydrocarbon based on the Hanus ester.

The invention belongs to the technical field of culture substrates, and particularly relates to a granular material prepared on the basis of biomass leavening and mineral substances and application of the granular material as a culture substrate. The granular material provided by the invention comprises the following raw materials: mineral powder, a biomass fermentation product, a polysaccharide-acid compound and a binder, the polysaccharide-acid compound is composed of chitosan and potassium humate, the polysaccharide-acid compound is loaded on mineral powder by adopting a vacuum negative pressure impregnation method, and finally the granular material is prepared. The granular material is stable in structure and high in moisture and fertilizer retention capacity, has biological activity and is environmentally friendly.

This invention belongs to the field of biomedical technology and discloses the use of fluoropyridoxal in the preparation of drugs for anticancer purposes, including: use in drugs for the prevention and / or alleviation and / or treatment of cancer. The cancer is ovarian cancer. The drug for the prevention and / or alleviation and / or treatment of cancer comprises fluoropyridoxal and a pharmaceutically acceptable carrier. The dosage form of the drug for the prevention and / or alleviation and / or treatment of cancer is tablets, granules, capsules, suspensions, syrups, emulsions, or injections. Fluoropyridoxal induces senescence-like death, cell cycle arrest, and apoptosis in cancer cells. Fluoropyridoxal acts by inducing apoptosis in cancer cells. The fluoropyridoxal of this invention can effectively inhibit the proliferation and growth of human ovarian cancer cell lines SKOV3, OVCAR3, 3AO, and ES-2. The fluoropyridoxal of this invention can be used as an effective drug for the treatment of ovarian cancer.

This invention provides recombinant humanized elastin, its preparation method, and its applications, relating to the field of bioengineering technology. Based on humanized elastin, this invention utilizes a combination design based on the functional domains of elastin to obtain recombinant humanized elastin, discovering novel bioactive functional fragments of humanized elastin. The recombinant humanized elastin of this invention integrates multiple elastin functional sites. Specifically, this recombinant humanized elastin exhibits significant effects in promoting cell proliferation and increasing the expression of collagen and elastin genes, demonstrating high safety and wide applicability in various scenarios, and providing a new active ingredient for anti-aging related products. Furthermore, the theoretical molecular weight of this recombinant humanized elastin is significantly smaller than that of natural full-length elastin, reducing obstacles for elastin to cross the skin barrier and exert its biological functions, thus exhibiting excellent biological efficacy.