20 results about "Phlorizin" patented technology

The invention provides an anti-anemia traditional Chinese medicine composition as well as a preparation method and application thereof. The anti-anemia traditional Chinese medicine composition is prepared from lithocarpus litseifolius, fructus gardeniae and rhizoma gastrodiae. The main active component dihydrochalcone (such as phlorizin, trilobatin, phloretin and the like) of lithocarpus litseifolius can improve iron metabolism by regulating a hepcidin-iron transporter axis; gardenoside in gardenia can target the liver to optimize iron distribution, and gastrodia elata polysaccharide can regulate immunity and improve the marrow microenvironment; the three forms a full-chain regulation and control network of intestinal tract iron absorption, liver iron utilization and bone marrow hematopoiesis microenvironment together, and the anti-anemia effect is enhanced in multiple dimensions.

The invention relates to the technical field of apple production place detection, in particular to a red Fuji apple production place discrimination method based on organic component analysis, which comprises the following steps: S1, constructing a linear discrimination function of organic components such as oxalic acid, succinic acid, tartaric acid, citric acid, malic acid, phlorizin, chlorogenic acid and rutin; s2, obtaining the contents of oxalic acid, succinic acid, tartaric acid, citric acid, malic acid, phlorizin, chlorogenic acid and rutin in the apple sample to be detected; s3, inputting the contents of oxalic acid, succinic acid, tartaric acid, citric acid, malic acid, phlorizin, chlorogenic acid and rutin in the obtained apple sample to be detected into the linear discrimination function, and taking a group of maximum discrimination function calculation values as a production area detection result. According to the method, the production places of red Fuji apples in five production areas can be discriminated to a certain extent through linear discrimination established on the basis of eight organic components, the classification accuracy rate reaches 95.2%, and technical support is provided for the production place traceability of the Jinning apples and the quality control of the apples.

This invention discloses the application of plant extracts in the preparation of drugs that inhibit canine parvovirus, belonging to the field of biomedical technology. The plant extract is at least one selected from phlorizin, neomethylhesperidin-dihydrochalcone, tribulus terrestris saponin, stevia glycoside, soy isoflavones, berberine hydrochloride, diosgenin, and silymarin. Through in-depth research on various plant extracts, this invention has found that phlorizin, neomethylhesperidin-dihydrochalcone, tribulus terrestris saponin, stevia glycoside, soy isoflavones, berberine hydrochloride, diosgenin, and silymarin all exhibit significant inhibitory effects on canine parvovirus, with soy isoflavones showing particularly outstanding effects. This research provides a novel natural drug option for the prevention and treatment of canine parvovirus. This invention not only expands the application scope of natural plant extracts in the veterinary medicine field but also provides important technical support for the development of novel, highly effective, safe, and side-effect-free drug formulations for the prevention and treatment of canine parvovirus.

The invention discloses a cyclodextrin-based antibacterial inclusion compound containing phloretin and a preparation method of the cyclodextrin-based antibacterial inclusion compound, and belongs to the technical field of antibacterial compositions.The preparation method comprises the steps that hydroxypropyl-beta-cyclodextrin is used as a ligand, under the ultrasonic assistance and potassium ion anchoring action, hydroxypropyl-beta-cyclodextrin MOF composite powder is prepared, and the cyclodextrin-based antibacterial inclusion compound containing phloretin is prepared; the preparation method comprises the following steps: dispersing hydroxypropyl-beta-cyclodextrin MOF composite powder with deionized water to obtain a nano-carrier stock solution, adding an inclusion stock solution containing phloretin, eugenol and thymol into the nano-carrier stock solution, carrying out stirring inclusion, carrying out centrifugal filtration, and drying a precipitate to obtain a cyclodextrin-based antibacterial inclusion compound containing phloretin; hP-beta-CD with the substitution degree of 3.15-6.98 is selected as a raw material, the hydrophobicity and hydrophilicity of a cavity of the HP-beta-CD can be balanced, and the prepared hydroxypropyl-beta-cyclodextrin MOF composite powder has a better inclusion effect on antibacterial inclusions.

A nanomaterial is gold or silver nanoparticle having a nanoparticle surface that consists of one or more of the following extracts from sweet gum leaves: shikimic acid, sweet gum leaf family of Catechins, sweet gum leaf family of Quercetin, Sweroside, Afzelechin, p-Coumaric Acid, Epiafzelechin Trimethyl Ether, Myricetin, Naringenin, Phloretin, Procyanidin B1 and related polyphenols, flavonoids and alkaloids. An antiviral / antibacterial agent includes sweet gum mediated silver nanoparticles having a core size and in a concentration having efficacy as an antiviral / antibacterial exceeding a 3 log 10 reduction in viral titer.

The invention discloses high-activity hypoglycemic strigose hydrangea juvenile leaf extract microcapsule powder and a preparation method thereof.The microcapsule powder is prepared through the method comprising the following steps that firstly, a high-voltage pulsed electric field (1-3 kV / cm) is adopted to assist alkalescent electrolyzed water to extract strigose hydrangea juvenile leaf, and a strigose hydrangea juvenile leaf extract (STE) is obtained; and mixing the extract with a wall material composed of at least two of maltodextrin, Arabic gum, inulin and arabinoxylan according to a mass ratio of 1: 0.25-1: 1.25, homogenizing, and spray-drying at an air inlet temperature of 140 + / -5 DEG C and an air outlet temperature of 80 + / -5 DEG C. The obtained microcapsule powder contains various high-content active ingredients such as 0.3 wt%-1.0 wt% of trilobatin and 0.3 wt%-1.0 wt% of phlorizin, and the embedding rate is high (for example, the embedding rate of total flavonoids is 67.53%-88.84%). According to the product disclosed by the invention, the bitter taste of the strigose hydrangea juvenile leaf is remarkably improved, the active ingredients can be effectively protected, the high inhibition activity on alpha-glucosidase and alpha-amylase can be maintained through simulated gastrointestinal tract digestion, the blood sugar reducing function is outstanding, and the product is suitable for preparing food, health care products or medicines with the blood sugar reducing function.

Provided herein are compositions and methods for reducing or preventing ovarian aging comprising: administering to a subject in need of a reduction or prevention of ovarian aging an effective amount of an SGLT2 antagonist. Examples of SGLT2 antagonists include canagliflozin, bexagliflozin, dapagliflozin, empagliflozin, ertugliflozin, sotagliflozin, phlorizin, or combinations thereof.

The invention provides a bifidobacterium longum subsp. Longum HX-BL11 capable of improving exercise fatigue, which is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.32960, and the preservation date is December 6, 2024. Meanwhile, the invention further provides a fermentation composition obtained by fermenting spina date seeds, hawthorn fruits, perilla seeds and dried tangerine or orange peel with the bifidobacterium longum subsp. Longum HX-BL11, and a fermentation product of the fermentation composition is rich in ferulic acid, phlorizin and hesperidin. The probiotic preparation and the fermentation product can improve the swimming exercise time of mice, improve indexes of fatigue damage degrees such as BUN, LD, LDH and CK-MB in the exercise mice, improve related indexes of energy metabolism such as GLU, MG and ATP, improve the exercise tolerance, improve antioxidant indexes such as T-SOD level and MDA content, improve the antioxidant capacity, play a synergistic effect and improve the health care effect of the mice. Therefore, the effect of relieving exercise fatigue is achieved. And meanwhile, the probiotic preparation of the bifidobacterium longum subsp. Longum HX-BL11 and the fermented product are simple in preparation method, can be produced in a large scale, and have a good application prospect.

The invention discloses an aleurites montana anthocyanin reductase VmANR gene and application thereof. The amino acid sequence of the aleurites montana anthocyanin reductase VmANR gene is shown as SEQ ID NO. 2. The content of compounds such as catechin, (-)-epicatechin, (-)-epigallocatechin, phlorizin and dihydromyricetin in transgenic hairy root plants over-expressed by the VmANR obtained by a transgenic means is remarkably increased, so that more flavonoid compounds can be extracted, separated and purified, and greater economic benefits are created; the method provides an important theoretical basis for increasing the content of flavonoid compounds in plants by using a biotechnological means in the future, and has a relatively high application value.

The invention belongs to the technical field of biology, and discloses a method for producing phloretin through fermentation of eurotium cristatum. On the basis of pretreatment of lithocarpus litseifolius, eurotium cristatum is used as a fermentation inoculant, and after aerobic solid fermentation is performed on the eurotium cristatum, trilobatin and phlorizin in the lithocarpus litseifolius are converted into phloretin. According to the method, eurotium cristatum is inoculated into lithocarpus litseifolius by utilizing a microbial solid-state fermentation technology, high-content phloretin is obtained after fermentation is finished, and the method is simple, convenient, short in production period and suitable for subsequent large-scale production.

This invention belongs to the field of pharmacology and provides the application of demethoxycurcumin and phlorizin in the preparation of drugs that inhibit β-lactoglobulin glycosylation. The synergistic inhibitory effects and mechanisms of demethoxycurcumin and phlorizin on AGEs were systematically investigated. Fluorescence spectroscopy and carbonyl / thiol / amino group assays confirmed that demethoxycurcumin and phlorizin can synergistically inhibit β-lactoglobulin glycosylation at appropriate concentrations. Circular dichroism spectroscopy and other experiments showed that the combined use of the two can better alleviate protein secondary structure changes and aggregation. They competitively bind to the same glycosylation site, synergistically resist oxidation, thereby inhibiting AGEs formation, and synergistically reducing oxidative stress, cell damage, and apoptosis at the cellular level. Therefore, the combined application of these two drugs has potential therapeutic value in intervening in diabetic complications.

The invention relates to the field of pharmaceutical preparations, in particular to a foaming agent for vagina pH adjustment and a preparation method thereof. The foaming agent comprises the following components in parts by weight: 5-8 parts of lactobacillus microcapsules, 1-2 parts of fructo-oligosaccharide, 3-4 parts of glycogen, 0.2 part of phlorizin, 2 parts of lactic acid, 1 part of citric acid, 0.5 part of sodium citrate, 8-10 parts of a propellant, 3.0 parts of sodium alginate and the balance of water, wherein the total parts by weight of the components are 100. The lactobacillus microcapsule is prepared from the following components: lactobacillus, trehalose and chitosan. According to the present invention, the micro-ecology can be rapidly recovered on the basis of the direct killing of pathogenic microorganisms by using the conventional treatment drug in the spaced cooperation manner; the lactobacillus microcapsules can effectively protect stable existence of lactobacillus before colonization in vaginal mucosa; the fructo-oligosaccharide and the glycogen provide substrates for the lactobacillus, help the lactobacillus to proliferate quickly, continuously maintain an acid environment and eliminate pathogenic bacteria through competitive inhibition.

The invention discloses a protein related to phloretin enzyme activity as well as a coding gene and application thereof. The technical problem to be solved is how to provide a phloretin enzyme activity related protein. The invention specifically discloses any one of the following applications: A1) application of the protein in catalyzing phloretin to generate phlorizin and / or trilobatin and / or preparing a product for catalyzing phloretin to generate phlorizin and / or trilobatin; a2) application in production of phlorizin and / or preparation of a product for producing phlorizin; and A3) producing trilobatin and / or preparing a product for producing the trilobatin. The protein is any one of the following: B1) a protein with an amino acid sequence as shown in a sequence 2; b2) a protein which is obtained by substitution and / or deletion and / or addition of amino acid residues of the protein B1), has 80% or more of identity with the protein B1) and has the same function as the protein B1); and B3) a fusion protein obtained by connecting the N terminal or / and the C terminal of B1) or B2) with a protein tag. The method can be used for industrial production.

This invention relates to a composition containing protoplasts of ginseng as an active ingredient, which improves aging caused by the deepening of wrinkles or loss of firmness in the skin. Specifically, the present invention contains protoplasts of ginseng as an active ingredient and can improve aging caused by deep wrinkles or loss of firmness of the skin. Furthermore, by including one or more components selected from the group consisting of phloretin, oryzanol, tranexamic acid, and pyridoxine, the stability of the composition can be enhanced and the effect of improving skin wrinkles and firmness can be strengthened by suppressing the clumping or cell membrane defects of the ginseng protoplasts in the composition.

The present invention discloses a skin care composition, comprising a first active component and a second auxiliary component. The first active component is selected from one or more of tetrahydrocurcumin, ergothioneine, phloretin, arbutin, resveratrol, vitamin C, dipotassium glycyrrhizinate, ceramide, Aloe vera polysaccharide, Opuntia dillenii polysaccharide, Astragali radix polysaccharide, Dendrobii caulis polysaccharide, Cucumis metuliferus polysaccharide, fucoidan, small-molecule hyaluronic acid, pearl powder, collagen, tea tree essential oil, thearubigins, salicylic acid, retinol, glycoxyl, carnosine; the second auxiliary component is selected from one or more of tetrahydropiperine, laurocapram, PEG-75 shea butter glycerides, hydrogenated castor oil, glycerol, lauric acid, sucrose laurate, butanediol, polysorbate, hydroxyethyl cellulose, 1,2-pentanediol, ethoxydiglycol. The skin care composition of the present invention can be used for whitening, anti-inflammatory, anti-glycation, moisturizing, skin firming, anti-bacterial and / or anti-aging.

The invention relates to a combination containing an extract of Coleus forskohlii, an apple extract rich in proanthocyanidins, an extract of grape pomace and a phloretin powder.

The invention provides pet cat food capable of improving immunity and a preparation method of the pet cat food, and relates to the technical field of pet food. The pet cat food capable of improving the immunity is prepared from cat food base food, plant extracts and probiotics, wherein the plant extract is prepared from the following components in percentage by mass: 3 to 10 percent of phlorizin, 5 to 10 percent of troxerutin and the balance of spirulina polysaccharide. By adding phlorizin, troxerutin and spirulina polysaccharide into the pet cat food, the immunity of pet cats is remarkably improved, and the incidence rate of diseases is effectively avoided.

The present invention relates to compositions and methods for improving metabolic health. Specifically, the present disclosure relates to using a methylated phloretin analog as a sodium-glucose transporter-2 (SGLT2) inhibitor for improving metabolic health.

The invention discloses an edible compound enzyme as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing fresh leaves of moringa oleifera and fresh leaves of lithocarpus litseifolius, and then carrying out composite enzymolysis pretreatment; then adding malt extract as a fermentation accelerant, and sequentially carrying out high-frequency sound wave fermentation and low-frequency sound wave auxiliary fermentation; and finally, carrying out sterilization and low-temperature concentration on the fermentation liquor to obtain the edible compound enzyme. According to the method, through cooperation of enzymolysis, a specific fermentation accelerant and two-stage variable-frequency sound wave auxiliary fermentation, characteristic active ingredients such as moringa oleifera flavone and Lithocarpus litseifolius fresh leaf dihydrochalcone (such as phlorizin) can be efficiently enriched, and the fermentation activity of an enzyme product is remarkably improved. The enzyme fermentation stock solution prepared by the method can be directly diluted with warm water for drinking, is harmonious in taste and rich in nutrition, and meets the requirements of ready-to-eat enzyme products; meanwhile, the compound can also be used as a functional fermentation raw material to be applied to baking food.