19 results about "Dehydroabietic acid" patented technology

The present application relates to the technical field of biosynthesis, and specifically discloses a method for selectively hydroxylating 16-position of dehydroabietyl acid based on CYP153 family cytochrome P450 enzyme, which comprises the following steps: plasmid construction, heterologous expression of CYP153A99-RhFRED in Escherichia coli, heterologous expression of opt13 in Escherichia coli, and crude enzyme catalytic conversion reaction. By optimizing the codon bias of the protein sequence of cytochrome monooxygenase in the CYP153 family, the p450 enzyme CYP153A99 with the biological catalytic function of catalyzing the hydroxylation of C16 position of dehydroabietyl acid is obtained, high-site selective oxidation of dehydroabietyl acid is realized, the substrate spectrum and application field of the CYP153 family P450 enzyme are expanded, and a new technical path is provided for the green synthesis of dehydroabietyl acid derivatives.

The present invention provides: a chloroprene polymer composition which is not susceptible to layer separation and coloring when mixed with a solvent, and which enables the preparation of an adhesive composition that is excellent in terms of storage stability; and a method for producing a chloroprene polymer composition. The present invention specifically provides a chloroprene polymer composition which contains a chloroprene polymer, wherein: the chloroprene polymer composition has a moisture content of 10 mass% or less; and the content C of dehydroabietic acid, which is present in the form of a dehydroabietic acid salt, with respect to 100 parts by mass of the chloroprene polymer composition is 0.075-1.600 parts by mass as measured by a specific measurement method.

The present invention belongs to the field of intelligent organosilicon polymer materials, and provides a kind of high-adhesion silicone resin antibacterial, anticorrosive coating and preparation method thereof.By organosilane modified natural antibacterial agent dehydroabietic acid, it is introduced into silicone resin system, and the antibacterial performance of silicone resin coating is improved.Using 3-aminopropyl triethoxysilane (KH-550) and γ-glycidyl ether oxygen propyl trimethoxysilane (KH-560) as raw materials, multifunctional siloxane (MF-S) is synthesized, as epoxy-amine curing agent, by condensation reaction, the cross-linking density of methylphenyl silicone resin is increased, so that it has excellent mechanical properties.After the obtained coating is cured at room temperature, the hardness reaches more than 6H, the adhesion reaches 1 grade, and the tensile strength of the obtained film reaches 9MPa.The silicone resin coating prepared by the present invention has good antibacterial performance, antifouling performance and anticorrosive performance, and the preparation method is simple and efficient, strong in practicality, has broad application prospects, and is conducive to realizing industrialized production.

The application discloses a self-shrinking, self-healing and multi-stimulus responding rosin-based copper salt supramolecular hydrogel as well as a preparation method and application thereof, and belongs to the technical field of hydrogels. The rosin-based copper salt supramolecular hydrogel is synthesized by means of coordination between copper nitrate and obtained disodium sulfonated dehydroabietic acid after sulfonation reaction and neutralization reaction of dehydroabietic acid as raw material, and has self-shrinking, self-healing and multi-stimulus responding performances. The preparation method of the hydrogel comprises the following steps: (1) preparation of sulfonated dehydroabietic acid; (2) preparation of disodium sulfonated dehydroabietic acid; and (3) preparation of the rosin-based copper salt supramolecular hydrogel. The rosin-based copper salt supramolecular hydrogel can realize self-shrinking of copper ions and maintain three-dimensional shape memory, and simultaneously has comprehensive performances of self-healing, multi-stimulus responding such as pH and oxidation and reduction, visual chiral identification, high conductivity and high swelling rate, and has inhibiting effects on pseudomonas aeruginosa and bacillus subtilis.

The invention belongs to the technical field of organic chemistry, and particularly relates to a dehydroabietic acid 1, 2, 3-triazole derivative as well as a preparation method and application thereof. The preparation method comprises the following steps: reacting dehydroabietic acid in a first organic solvent under the action of a reducing agent to obtain a compound 2 with reduced carboxyl; reacting the compound 2 with p-toluenesulfonyl chloride under the action of an alkali solution to obtain a hydroxyl-protected compound 3; in a second organic solvent, reacting the compound 3 with sodium azide under a high-temperature condition to obtain an azide compound 4; and reacting the compound 4 with a copper salt and an alkyne compound in a polar solvent of alkali to obtain a target compound. The dehydroabietic acid derivative with high biological activity is synthesized, raw materials are cheap and easy to obtain, reaction conditions are mild, aftertreatment is simple, the yield is high, a virulent solvent is not used in the synthesis process, the green chemical requirement is met, high pressure or a special catalyst is not needed, and large-scale production can be achieved in conventional equipment.

The invention discloses a preparation method of a dehydroabietic acid guar gum ester (DGE) bonded silicon dioxide stationary phase, which comprises the following steps: carrying out carboxylation on the surface of SiO2 microspheres by reacting with succinic anhydride, then reacting with acyl chloride to carry out acylating chlorination, and finally carrying out chemical bonding with DGE to prepare amphiphilic DGEII-coated 10SiO2 solid particles. The degree of substitution of DGE is 0.7-1.5, the aperture of DGE II-coated 10SiO2 solid particles is 5-30nm, the specific surface area is 247m < 2 > / g, and the DGE II-coated 10SiO2 solid particles are uniform in particle size and high in mechanical strength and can be used as liquid chromatographic column packing. The preparation method is simple and good in repeatability, and the successfully prepared stationary phase has certain amphipathy due to DGE, has good selective separation performance on saponin drugs, and has wide application prospects in the aspect of drug separation and purification.

The present invention discloses a cationic surfactant and its preparation and application. The structure of the cationic surfactant is: #imgabs0# A method for preparing the cationic surfactant comprises: (1) reacting dehydroabietic acid with thionyl chloride under the catalysis of 4-dimethylaminopyridine to obtain dehydroabietic acid chloride; (2) reacting dehydroabietic acid chloride with aminoundecanoic acid methyl ester hydrochloride to obtain compound 1; (3) reacting compound 1 with 3-dimethylaminopropylamine to obtain compound 2; and (4) reacting compound 2 with ethyl bromide to obtain the cationic surfactant. The cationic surfactant provided by the present invention can have high viscoelasticity at a relatively low concentration and has low application cost.

The present application relates to the technical field of thickening agent, and discloses a fracturing fluid thickening agent and a preparation method thereof, which comprises the following steps: adding dehydroabietyl acid into thionyl chloride to prepare dehydroabietyl acid chloride; adding the dehydroabietyl acid chloride into 2-amino terephthalic acid to obtain an intermediate A; reacting the intermediate A to obtain modified acrylamide; dissolving the modified acrylamide, acrylamide, 2-acrylamido-2-methylpropanesulfonic acid and dimethyl diallyl ammonium chloride in deionized water, and adding them into an oil phase to obtain a mixed solution; adding acrylic acid into the mixed solution and adjusting the pH of the solution; continuing to pass nitrogen, adding an initiator, and then carrying out a reaction under temperature rising to obtain the fracturing fluid thickening agent. The rigid dehydroabietyl acid phenanthrene ring structure, the multi-functionality amide structure and the double bond structure further strengthen the polymerization of the polymer and the formation of the hydrogen bond in the compound, and further improve the heat resistance and sand carrying capacity of the fracturing fluid thickening agent.

The present invention discloses a dehydroabietic acid-based aggregation-inducing red light compound, a preparation method thereof, and its use. The structural formula of the dehydroabietic acid-based aggregation-inducing red light compound is: #imgabs0# The dehydroabietic acid-based aggregation-inducing red light compound is prepared by reacting 12-[N,N-p-methoxy-phenyl]amino-dehydroabietic acid methyl ester and 2,3-bis(4-bromophenyl)-2-butene dinitrile. The dehydroabietic acid-based aggregation-inducing red light compound 2DTPA-CN of the present invention has excellent spectral properties, effectively extends the fluorescence emission wavelength of the dehydroabietic acid-based compound, has low cytotoxicity and strong anti-photobleaching performance, can be used as a fluorescent probe in cell imaging, and can also be used as an anti-counterfeiting material in colored fluorescent anti-counterfeiting, etc.; and is simple to prepare and easy to operate.

The invention relates to the technical field of polysaccharide modification, in particular to dehydroabietic acid locust bean gum ester and a preparation method and application thereof.Purified locust bean gum and dehydroabietic acid acyl chloride serve as raw materials, pyridine serves as a catalyst, an acid-binding agent and a solvent at the same time, heating reaction is conducted under the protective atmosphere, ester is generated, and the dehydroabietic acid locust bean gum ester is obtained. After the reaction is finished, carrying out first centrifugation, and collecting the precipitate for the first time to obtain a first product; performing Soxhlet extraction on the first product, and drying to obtain dehydroabietic acid locust bean gum ester insoluble in pyridine; adding the centrifugate after the first centrifugation into a mixed solution containing methanol and water, precipitating, carrying out second centrifugation, and then collecting the precipitate for the second time to obtain a second product; and carrying out Soxhlet extraction on the second product, and drying to obtain the dehydroabietic acid locust bean gum ester dissolved in pyridine. The esterification product obtained by the invention has amphipathy, and the raw materials locust bean gum and dehydroabietic acid are natural sources, so that the esterification product has good biocompatibility and safety.

This invention discloses a method for preparing dehydroabscisic acid locust bean gum ester-bonded silica microspheres. The method uses dehydroabscisic acid locust bean gum ester (DLE) as a functional monomer. By adjusting the degree of substitution of DLE (0.001–2.5), an esterification reaction is carried out with a silica derivative to obtain dehydroabscisic acid locust bean gum ester-bonded silica microspheres (DLE@SiO231). These microspheres are then treated with a blocking agent to obtain blocked microspheres (DLE@SiO231M). The resulting microspheres have a particle size of 2–10 μm, an average pore size of 2–70 nm, and a specific surface area of ​​50–600 m². 2 The material exhibits uniform particle size and high mechanical strength. It can be used as a packing material for high-performance liquid chromatography (HPLC) columns or for solid-phase extraction. Due to the introduction of DLE (dihydrolamine), it possesses amphiphilic properties and demonstrates excellent selective separation capabilities for saponin drugs, showing broad application prospects in the field of drug separation and purification.

The present invention discloses a dehydroabietic acid PROTACs, a preparation method and an application thereof, wherein the structural formula is: The present invention can exert anti-liver fibrosis activity by targeted degradation of pathogenic proteins that cause liver fibrosis.

This invention relates to the field of dehydroabietic acid compounds, specifically disclosing the preparation method and application of dehydroabietic acid-based D-A type polar responsive fluorescent compounds. These compounds include dehydroabietic acid thiadiazole-carbazole, dehydroabietic acid thiadiazole-triphenylamine, dehydroabietic acid thiadiazole-dimethylaniline, and dehydroabietic acid thiadiazole-phenoxazine. This invention introduces groups with different electron-donating abilities onto the natural acceptor dehydroabietic acid thiadiazole to obtain dehydroabietic acid-based D-A type fluorescent compounds, thus developing dehydroabietic acid-based D-A type fluorescent compounds for the first time. These dehydroabietic acid-based D-A type fluorescent compounds exhibit good fluorescence performance accompanied by a redshift in fluorescence wavelength due to increased electron-donating ability, while also possessing good polar response performance. Among them, the good biocompatibility and steroid-like skeleton structure of dehydroabietic acid thiadiazole-dimethylaniline enable specific targeting of lipid droplets, making it a promising fluorescent probe for application in the field of bioimaging and demonstrating excellent practicality.

The invention belongs to the technical field of biological medicines, and particularly discloses a dehydroabietic acid-dithiocarbamate derivative as well as a preparation method and application thereof. The dehydroabietic acid-dithiocarbamate derivative is a compound with a structural general formula as shown in a formula (I), or a pharmaceutically acceptable salt, a solvate or a hydrate of the dehydroabietic acid-dithiocarbamate derivative. The invention discloses a dehydroabietic acid-dithiocarbamate derivative as well as a preparation method and application thereof. The dehydroabietic acid-dithiocarbamate derivative is high in anti-tumor activity, excellent in selectivity and small in toxic and side effects. (I).

To provide a chloroprene polymer composition which is not susceptible to layer separation and coloring when mixed with a solvent, and which enables the preparation of an adhesive composition with excellent storage stability, and a method for producing a chloroprene polymer composition.SOLUTION: According to the present invention, there is provided a chloroprene polymer composition including a chloroprene polymer, the chloroprene polymer composition having a moisture content of 10 mass% or less, and a content C of dehydroabietic acid, which is present in the form of a dehydroabietic acid salt, being 0.075 to 1.600 pts.mass per 100 pts.mass of the chloroprene polymer composition as measured by a specific measurement method.SELECTED DRAWING: None

A method for manufacturing a chloroprene polymer composition, the method including: a polymerization step of polymerizing chloroprene in the presence of at least one rosin acid component selected from the group consisting of a rosin acid and a rosin acid salt to obtain a chloroprene polymer composition containing a chloroprene polymer, in which in the rosin acid component, a mass ratio B1 / A1 of a total amount B1 of abietic acid, neoabietic acid, palustric acid, levopimaric acid, and salts thereof with respect to a total amount A1 of dehydroabietic acid, pimaric acid, isopimaric acid, dihydroabietic acid, and salts thereof is 0.10 to 3.00, and a toluene insoluble content of the chloroprene polymer is 50% by mass or more.

The invention provides a method for preparing disproportionated rosin. The method comprises the following steps: a raw material pretreatment stage, a clarification and separation stage, a primary reaction stage, a catalytic disproportionation stage and a post-treatment stage to obtain a disproportionated rosin product. According to the method, three-step chemical modification of the porous ceramsite carrier is combined with a stepped temperature control strategy, so that the content of dehydroabietic acid in a disproportionated rosin product is increased, abietic acid residues are reduced, meanwhile, the stability of the catalyst is effectively improved, and the technological process is simplified.

The application discloses a dehydroabietic acid-based aggregation-induced emission (AIE) and excited-state intramolecular proton transfer (ESIPT) dual-property compound, a preparation method and application thereof. The structural formula of the dehydroabietic acid-based aggregation-induced emission (AIE) and excited-state intramolecular proton transfer (ESIPT) dual-property compound is as follows: the dehydroabietic acid-based aggregation-induced emission (AIE) and excited-state intramolecular proton transfer (ESIPT) dual-property compound is prepared from the reaction of 12-[N,N-p-methoxy-4-boronate phenyl] amido-dehydroabietic acid methyl ester and 2-(benzo[d]thiazole-2-yl)-4-bromophenol. The dehydroabietic acid-based aggregation-induced emission (AIE) and excited-state intramolecular proton transfer (ESIPT) dual-property compound DTPA-HBT has a large Stokes shift, can be used for fluorescence imaging, and can also be applied to fluorescence anti-counterfeiting; and the synthetic route is mild, controllable and easy to operate.

The invention discloses a modified nucleating agent and a preparation method thereof, a polypropylene composite material and a preparation method thereof, and a refrigerator. Raw materials for forming the modified nucleating agent comprise cellulose whiskers, dehydroabietic acid and sorbic acid. According to the modified nucleating agent disclosed by the embodiment of the invention, the modified nucleating agent has the properties of nucleating property, antibacterial property, toughening property and the like, so that'one carrier has multiple functions'. When the modified nucleating agent is used in a polypropylene composite material, the material is endowed with transparency, antibacterial activity and good low-temperature toughness, and the problem that the transparency uniformity of an antibacterial transparent material is difficult to realize can be effectively solved.