51 results about "Filaggrin" patented technology

The invention relates to a preparation method and application of a sensitive skin repairing composition containing phellinus igniarius PDRN, and belongs to the technical field of cosmetics. The sensitive skin repairing composition is prepared from phellinus medicinus PDRN, bio-saccharide gum-1 and tephrosia esculenta seed extract, and the three components have a synergistic effect and can effectively promote the generation of three barrier proteins, namely tight junction protein, biaprylin and fibroin, so that the skin barrier function is strengthened, the long-acting repairing of sensitive skin is realized, and the skin sensitivity is reduced.

To provide agents for promoting epidermal keratinocyte growth, filaggrin mRNA expression, serine palmitoyltransferase mRNA expression, involucrin expression or ATP production by finding substances having excellent activity in promoting epidermal keratinocyte growth, filaggrin mRNA expression, serine palmitoyltransferase mRNA expression, involucrin expression or ATP production.SOLUTION: An epidermal keratinocyte growth promoting agent of the invention comprises one or more effective ingredients selected from the group consisting of 2-ketoglutaric acid, 2-isopropyl malate, inosine 5'-monophosphoric acid, succinic acid, malic acid and pyruvic acid. Also, a filaggrin mRNA expression promotor, a serine palmitoyltransferase mRNA expression promotor, an involucrin expression promotor of the invention comprise, as an effective ingredient, 2-ketoglutaric acid. Further an ATP production promotor of the invention comprises 2-isopropyl malate as an effective ingredient.SELECTED DRAWING: None

The invention discloses sargassum fusiforme polysaccharide with a barrier repairing function and a preparation method and application thereof. The molecular weight of the sargassum fusiforme polysaccharide is 39-278 kDa, the total sugar content is 50-55 wt%, and the uronic acid content is 29-35 wt%. The preparation method comprises the following steps: (1) hot water extraction: mixing sargassum fusiforme powder with water, and performing hot water extraction, evaporation concentration, alcohol precipitation and freeze-drying; (2) ultrasonic treatment: mixing with water, and performing ultrasonic degradation; and (3) UV / H2O2 degradation: mixing with a H2O2 solution, carrying out UV degradation, removing H2O2, dialyzing, evaporating and concentrating, and freeze-drying to obtain the product. The sargassum fusiforme polysaccharide prepared by the invention can significantly improve the content and expression of filagarisin (FLG) of nude mice and HaCaT cells after UVB irradiation, reduces the percutaneous moisture loss value (TEWL) in nude mice, has a significant skin barrier repair function, and can be used for development and utilization of functional foods and skin care products.

The present invention relates to a polymer self-assembly nanocarrier and a method of preparing same, the nanocarrier binding a peptide that targets a specific cell and, simultaneously, carrying an active ingredient that has been verified. The present invention can exhibit various effects such as a moisturizing effect, an increase in filaggrin production, whitening, skin barrier reinforcement and the like by selectively and efficiently delivering a drug through a targeting peptide, can be applied to skin diseases such as atopy or psoriasis, and is expected to enable the maximum effect of an active substance in the pharmaceutical and cosmetic fields to be obtained.

The present invention relates to a pharmaceutical composition comprising a tubulin inhibitor as an active ingredient for preventing or treating skin diseases. In addition, the present invention relates to a quasi-drug composition or cosmetic composition comprising a tubulin inhibitor as an active ingredient for preventing or alleviating skin diseases. In addition, the present invention relates to a cosmetic composition comprising a tubulin inhibitor as an active ingredient for skin moisturization, whitening, wrinkle alleviation, acne relief, skin barrier strengthening, or skin keratinocyte differentiation. The tubulin inhibitor of the present invention increases the expression level of filaggrin in epidermal cells, promotes skin differentiation, inhibits NF S-kB signaling induced by TNF-α, and exhibits photo-aging inhibition and wrinkle alleviation effects as well as whitening effects. Accordingly, the tubulin inhibitor of the present invention can be utilized as an active ingredient that exhibits activities, such as skin moisturization, whitening, wrinkle alleviation, acne relief, skin barrier strengthening, or skin keratinocyte differentiation, along with the prevention, treatment, or alleviation of skin diseases.

A topical composition for treating diabetic skin conditions is disclosed, comprising a non-steroidal, non-comedogenic, and fragrance-free formulation. The composition includes a synergistic blend of emollients, humectants & occlusives for intense moisturization; emulsifying agents for stabilization; moisturizing agents for enhanced hydration; antioxidants for reducing oxidative stress; anti-inflammatory agents for alleviating inflammation; anti-itching agents for relieving the itching; skin conditioners for improved barrier function; Filaggrin improver and agents for stimulating collagen production. The composition provides relief from dry skin, itching, and redness associated with diabetic skin conditions.

Disclosed herein are methods of detecting citrullinated polypeptides and / or citrullinated peptides. Citrullinated polypeptides, such as citrullinated vimentin, fibrinogen, and filaggrin, are expressed in various body fluids and / or tissues of individuals with autoimmune diseases, for example the synovium of subjects with rheumatoid arthritis. Further disclosed are methods of diagnosing, treating, selecting an individual for treatment of, and monitoring the treatment of autoimmune diseases, such as rheumatoid arthritis or hidradenitis suppurativa. Kits for use with the methods described herein are also provided.

Disclosed in the present application are an isolated anti-IL-17RB antibody or antigen-binding fragment thereof, or a pharmaceutical composition containing same, which are used for treating FLG-associated diseases. The anti-IL-17RB antibody or antigen-binding fragment thereof or the pharmaceutical composition containing same can reverse Th2-driven downregulation of filaggrin expression, and can thus effectively treat FLG-associated diseases.

The present invention belongs to the technical field of daily-use cosmetics, and discloses an anti-glycation and antioxidant composition, an anti-aging cream and a preparation method thereof. The anti-glycation and antioxidant composition of the present invention comprises the following components in parts by weight: 0.1-1.5 parts of carnosine hydrochloride, 0.2-10.4 parts of algal extract, and 0.1-12.5 parts of yeast / rice fermentation product filtrate. Compared with the prior art, the anti-aging cream containing the anti-glycation and antioxidant composition of the present invention has excellent anti-glycation and antioxidant effects and good absorbability at the same time, can reduce oxidative and glycation damage, inhibit the degradation of matrix metalloproteinase, thereby improving wrinkles, brightening the skin and promoting the generation of collagen. At the same time, the present invention also has the functions of moisturizing, supplementing filaggrin or underlying fibers of the skin, and exhibits excellent skin conditioning effects.

To provide a novel trans epidermal water loss inhibitor and a moisturizing agent using the inhibitor.SOLUTION: The characteristics of the present invention in order to solve the problem are as follows. 1. A trans epidermal water loss inhibitor has a kudzu vine-derived lactic acid bacterium (Leuconostoc mesenteroides) as an active ingredient. 2. The trans epidermal water loss inhibitor described in 1 above in which the kudzu vine-derived lactic acid bacterium (Leuconostoc mesenteroides) is a lactic acid bacterium (Leuconostoc mesenteroides) (Patent Organisms Depositary accession number: NITE P-02751) strain and / or a variant thereof. 3. A skin roughness improver has the trans epidermal water loss inhibitor described in 1 or 2 above as an active ingredient. 4. A moisturizing agent has the trans epidermal water loss inhibitor described in 1 or 2 above as an active ingredient. 5. A horny layer moisturizing and barrier protein (involucrin, filaggrin, transglutaminase 1) expression promoter has a kudzu vine-derived lactic acid bacterium (Leuconostoc mesenteroides)(Patent Organisms Depositary accession number: NITE P-02751) strain and / or a variant thereof as an active ingredient.SELECTED DRAWING: None

The application belongs to the technical field of biotechnology and cosmetics, and discloses a polypeptide with skin barrier repair activity and application thereof. The polypeptide is an enzymatic fragment derived from Bacillus subtilis neutral metalloproteinase A7UAM1, and the amino acid sequence is shown as SEQ ID NO:1. The mutant is a site-directed mutant of the wild-type A7UAM1, and is preferably a H142A / E143A double mutant. Compared with the wild-type enzyme, the proteolytic activity of the polypeptide and the mutant is reduced by greater than or equal to 90%, but the activity of promoting keratinocytes to express filaggrin (FLG) and loricrin (LOR) is not reduced or is significantly improved, and the application realizes the decoupling of the functions of 'gentle exfoliation' and 'active barrier repair'. The polypeptide or the mutant can be applied to the preparation of cosmetics or drugs with the effects of skin barrier repair, anti-sensitivity and anti-photoaging, and is especially suitable for sensitive skin and post-medical aesthetic repair.

The present invention discloses a recombinant humanized filaggrin and its uses. The recombinant humanized filaggrin contains a humanized LEKTI protein fragment, and the humanized LEKTI protein fragment contains the humanized Kazal motif protein sequence shown in SEQ ID No.2; it also contains a humanized FLG protein fragment, and the humanized FLG protein fragment is linked to the humanized LEKTI protein fragment through a linker containing a furin cleavage site. After cleavage by interstitial furin protease, the two protein fragments perform their respective functions. The recombinant humanized filaggrin of the present invention has the prospect of being developed into a drug, a cosmetic or a medical device for treating diseases that can be treated or alleviated by supplementing FLG and / or inhibiting kallikrein KLK5. Diseases that can be treated or alleviated by supplementing FLG and / or inhibiting KLK5 include atopic dermatitis, Netherton syndrome and tumors with high expression of KLKs.

The present invention relates generally to the identification and use of a Kangpu tea extract, an alpha-glucan oligosaccharide, or a mixture thereof, which is capable of increasing skin barrier protection, as assessed by increasing the ability of a specific biomarker for cell differentiation, as well as, for example, a Kangpu tea extract, an alpha-glucan oligosaccharide, or a mixture thereof, as well as, for example, a Kangpu tea extract, an alpha-glucan oligosaccharide, or a mixture thereof. Particularly, measurement is carried out through the expression of silk protein and endoprotein. A composition can be used in a method for improving the aesthetic appearance of human skin affected by impairment of skin barrier comprising topically applying thereto a therapeutically effective amount of an active agent wherein the active agent is applied ex vivo to human skin keratinocytes in a cosmetically acceptable vehicle at a concentration of at least 0.45% w / w, and the synthesis of the inner cover protein and / or the silk protein can be increased by more than 40%.

The present invention relates to a pharmaceutical composition for preventing or treating allergic skin diseases or pruritus, and more specifically, to: a pharmaceutical composition for preventing or treating allergic skin diseases or pruritus, the pharmaceutical composition containing ABT-751 or TN-16 as an active ingredient; a cosmetic composition for preventing or improving allergic skin disease or pruritus, the cosmetic composition containing ABT-751 or TN-16 as an active ingredient; and a cosmetic composition for skin moisturization, the cosmetic composition containing ABT-751 or TN-16 as an active ingredient. A composition for preventing, improving, or treating atopic dermatitis according to the present invention was found to effectively increase the expression of filaggrin in skin cells and improve skin barrier function, and thus have the effect of effectively ameliorating or treating the symptoms of allergic skin diseases including atopic dermatitis or pruritus, and have an excellent skin moisturizing effect.

The present invention relates to a pharmaceutical composition for preventing or treating allergic skin diseases or skin itch, and more particularly, to a pharmaceutical composition for preventing or treating allergic skin diseases or skin itch, containing ABT-751 or TN-16 as an active ingredient, a cosmetic composition for preventing or ameliorating allergic skin diseases or skin itch, which contains ABT-751 or TN-16 as an active ingredient; and a cosmetic composition for moisturizing skin, which contains ABT-751 or TN-16 as an active ingredient. The composition for preventing or improving and treating atopic dermatitis according to the present invention effectively increases the expression of silk protein in skin cells and improves the skin barrier function, thereby having the effect of effectively improving or treating the symptoms of allergic skin diseases including atopic dermatitis or skin itch. And it is confirmed that an excellent skin moisturizing effect is exhibited.

The invention discloses a new application of isopentadecanoic acid, and discloses an application of isopentadecanoic acid in preparation of skin care cosmetics, isopentadecanoic acid has the effects of up-regulating expression of hBD-2 and silk protein in human immortalized keratinocytes, reducing expression synthesis of ROS and TRPV1 in the human immortalized keratinocytes, inhibiting release of NO by mouse macrophages, and inhibiting expression of the human immortalized keratinocytes. And the secretion of sebaceous gland cell grease is reduced.

The present application discloses an isolated anti-IL-17RB antibody, or an antigen binding fragment thereof, or a pharmaceutical composition comprising the same, for treating FLG-associated diseases, which is capable of reversing the down-regulation of Th2-driven filaggrin expression, and thus can effectively treat FLG-associated diseases.

To provide a novel agent for promoting the production of filaggrin and / or epidermal hyaluronic acid.SOLUTION: An agent for promoting the production of filaggrin and / or epidermal hyaluronic acid contains at least one compound selected from the group consisting of citronellyl glucoside, citronellyl mannoside, citronellyl galactoside, citronellyl maltoside, citronellyl lactoside, citronellyl sophoroside, and pharmaceutically acceptable salts thereof.SELECTED DRAWING: None

The present invention relates to a novel pseudo-ceramide compound and a method for preparing same, the compound being represented by chemical formula 1. The pseudo-ceramide of the present invention not only has a moisturizing effect, increased filaggrin production, and an anti-inflammatory effect, but also has a simple and economical synthesis process, and is suitable for use in a topical dermatologic composition for skin moisturization and cosmetic applications. [Chemical Formula 1] wherein A* is hydrogen or an acyl group of a C7-C16 saturated or unsaturated aliphatic chain, which is unsubstituted or substituted with a hydroxyl group, R1 is a C7-C15 saturated or unsaturated aliphatic chain which is unsubstituted or substituted with a hydroxyl group, and the difference in the number of carbon atoms between A* and R1 is at least 7.

This invention belongs to the field of daily chemical products and discloses a polysaccharide composition that improves skin immunity and strengthens the skin barrier function, as well as its applications. The polysaccharide composition includes Scutellaria baicalensis polysaccharide, Adenophora stricta polysaccharide, and Trametes versicolor polysaccharide. Through the synergistic effect of these three polysaccharides, it can not only reduce the number of mast cells but also increase antimicrobial peptides and filaggrin; increase filaggrin; and decrease monocyte chemotactic protein-1 and interleukin-6, thereby achieving the effects of improving skin immunity, anti-inflammatory and whitening. Furthermore, it can act as a signaling molecule, widely participating in physiological processes such as intercellular ligand-receptor recognition and intercellular signal transduction, reducing the average relative amplification fold of interleukin-6 expression factor mRNA, and effectively participating in epidermal cell differentiation and skin barrier formation, thus strengthening the skin barrier function; it can be used in the preparation of cosmetics.

This invention discloses a cyclic nonapeptide with skin barrier repair and anti-inflammatory effects. The amino acid sequence of the cyclic nonapeptide is: cyclic (arginine-glycine-aspartic acid-serine-arginine-lysine-valine-lysine-tryptophan). The cyclic nonapeptide of this invention can increase the relative expression levels of lobe rhabdominis (LOR), filaggrin (FLG), and aquaporin 3 (AQP3) genes, and reduce the secretion of inflammatory factors IL-6 and IL-8, thereby exhibiting skin barrier repair and anti-inflammatory effects.

The present invention belongs to the field of bioengineering, and particularly relates to a recombinant humanized filaggrin with good moisturizing effect, a preparation method thereof, and an application thereof. By screening different fragments of natural filaggrin and expressing recombinant humanized filaggrin FLG using Escherichia coli, the present invention successfully prepares a recombinant humanized filaggrin FLG with good moisturizing effect, and its amino acid sequence is selected from one of SEQ ID NO.11, SEQ ID NO.12, SEQ ID NO.13, SEQ ID NO.14, and SEQ ID NO.15. It has been proven by experiments that the recombinant humanized filaggrin prepared by the present invention not only has good cell adhesion and cell migration activities, but also has good actual moisturizing experimental effects when applied to the human body, and has good practical application value.

The application relates to the cosmetic technical field, and particularly discloses a water-oil balance composition suitable for sensitive skin and application thereof. The components in a suitable mass ratio range are matched with each other, so that the temperature-sensitive receptors of the skin can be synergistically regulated, natural moisturizing production is promoted, and ultraviolet protection is improved. The water-oil balance composition can selectively inhibit TRPV1-mediated 5alpha-reductase activity and ultraviolet-induced oxidative stress under high temperature in summer, accurately regulate sebum secretion without damaging the barrier, and promote the generation of natural moisturizing factors by activating filaggrin degradation in a low-temperature environment in winter, dynamically adjust the hydration degree of the stratum corneum, break through the technical limitations of traditional products, such as seasonal use and single and one-sided functions of active ingredients, realize cross-seasonal balanced care of a single formula, and are mild and non-irritating, and are suitable for sensitive skin.

The present invention relates to delivering benefits related to maintaining a resilient microbiome on skin through a personal care composition, especially through wash off compositions like soap, body wash or shampoo. This is achieved by using starch or its microbial metabolite preferably in such compositions. It works by upregulating expression levels of Aquaporin-3, Claudin 1, Keratin- 4, Filaggrin- 1 or Desmoglein 1 on skin.

The present invention relates to a novel Sphingomonas paucimobilis strain. In addition, it relates to a use of Sphingomonas paucimobilis strain. Specifically, it relates to a method or composition for preventing or improving skin wrinkles, enhancing skin elasticity, reinforcing a skin barrier, or moisturizing the skin using the strain. The novel Sphingomonas paucimobilis strain according to the present invention can inhibit the expression of a collagen-degrading enzyme MMP-1, and promote the expression of collagen, filaggrin and claudin-1 that exhibit effects to improve skin wrinkles, enhance skin elasticity, strengthen skin barrier, and moisturize the skin. Therefore, the strain can be usefully used to prevent or improve skin wrinkles, enhance skin elasticity, strengthen the skin barrier, and / or moisturize the skin.

The present disclosure provides methods and compositions for treating skin diseases, including engineered microorganisms expressing therapeutically relevant recombinant fusion polypeptides. In one embodiment, the present disclosure provides methods for treating skin diseases (e.g., atopic dermatitis), comprising administering to a subject in need thereof a composition comprising a live biotherapeutic product (LBP), the LBP comprising Staphylococcus epidermidis secreting human filaggrin. In a further aspect, the present invention provides a pharmaceutical composition comprising a filaggrin polypeptide as described herein. Still further, the present invention provides a kit comprising the compositions disclosed herein and instructions for use.

The invention discloses a composition for turning white hair into black hair and application of the composition. The composition for turning the white hair into the black hair is prepared from the following components in parts by mass: 1.5 to 5.0 parts of hydroxyethyl piperazine ethanesulfonic acid, 0.5 to 3.5 parts of arginine, 40.0 to 80.0 parts of glycoprotein, 24.0 to 40.0 parts of hydroxyferriheme and 0.1 to 0.6 part of vitamin C, the composition disclosed by the invention can penetrate into hair follicles to play a role, activate a plurality of MITF pathways in melanocytes in the hair follicles, induce melanin, an antioxidant and a stem cell protection factor generation receptor to react, effectively promote the function of the melanocytes, and effectively promote white hair to become black hair for a long time. Meanwhile, the composition for turning the white hair into the black hair can promote generation of fibroin of keratinocytes, scalp barrier repairing is achieved, and the combing performance of the hair and the brightness of the hair can be improved.

The present invention relates to a preparation method of an Erigeron breviscapus extract, its product and application. The preparation method of the Erigeron breviscapus extract comprises the following steps: mixing an Erigeron breviscapus raw material with an extraction solvent and then carrying out water bath heating extraction, centrifuging and filtering the extraction solution to obtain a filtrate, thus obtaining the extract; the extraction solvent is selected from a deep eutectic solvent or a mixed solvent of a deep eutectic solvent and water. This preparation method creatively uses a deep eutectic solvent or a mixed solvent of a deep eutectic solvent and water to extract the Erigeron breviscapus raw material. On the one hand, it can make the contents of scutellarin and total flavonoids in the obtained extract high, providing an effective strategy for the utilization of the Erigeron breviscapus raw material and the preparation of scutellarin; on the other hand, the obtained extract also has excellent inhibitory activities against hyaluronidase, elastase and collagenase, excellent promoting expression activities of aquaporin, filaggrin and involucrin, excellent anti-free radical activity and excellent anti-aging activity.

The present disclosure relates to a cosmetic composition containing an extract of Cyperus rotundus extracted using warm microbubbles. The extract inhibits nitric oxide (NO) production and exhibits excellent anti-inflammatory efficacy by inhibiting the expression of interleukin 6 (IL-6), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α), which are inflammatory expression factors. In addition, the extract enhances the expression of aquaporin-3 (AQP-3), hyaluronan synthase 2 (HAS-2), claudin-1 (CLDN-1), cadherin 1 (CDH1), filaggrin (FLG), and involucrin (IVL), which are genes related to the skin barrier and moisturizing. Thus, when using the extract for cosmetic products, excellent effects can be exhibited in skin soothing, moisturizing, enhancement of the skin barrier, relief of irritation such as erythema, relief of pruritus, and the like, so the extract can be usefully applied to multi-care products that improve skin conditions.

The present invention relates to an oil-in-water type cosmetic composition in which visible dermacosmetic oil particles carrying skin-beneficial ingredients, such as compounds, peptides, or natural oils having skin regeneration, whitening, or antioxidant effects, are supported. More particularly, the present invention relates to an oil-in-water type cosmetic composition in which visible oil particles constituting an oil phase are dispersed in a continuous aqueous phase, wherein the aqueous phase includes an acrylic polymer and water, the oil phase includes an oil, a gelling agent, and a skin-beneficial ingredient, and the oil is a mixture of two or more oils including a low-viscosity oil and a high-viscosity oil. Utilizing the visible oil particles, the present invention can efficiently deliver the beneficial ingredients into the skin, exhibit various effects, including moisturizing, increased filaggrin production, skin whitening, and enhancement of the skin barrier, and also be applied to skin diseases such as atopic dermatitis and psoriasis. In addition, the composition maintains the stability of the emulsified particles and prevents mixing with other oils even without the use of surfactants or emulsifiers, exhibits low hardness and a low thixotropic index to provide a smooth application to the skin and maximum sensory properties, and offers aesthetic appeal, thereby enabling broad applications not only in cosmetics but also in the pharmaceutical field.