25 results about "Filaggrin" patented technology

The invention relates to a preparation method and application of a sensitive skin repairing composition containing phellinus igniarius PDRN, and belongs to the technical field of cosmetics. The sensitive skin repairing composition is prepared from phellinus medicinus PDRN, bio-saccharide gum-1 and tephrosia esculenta seed extract, and the three components have a synergistic effect and can effectively promote the generation of three barrier proteins, namely tight junction protein, biaprylin and fibroin, so that the skin barrier function is strengthened, the long-acting repairing of sensitive skin is realized, and the skin sensitivity is reduced.

To provide agents for promoting epidermal keratinocyte growth, filaggrin mRNA expression, serine palmitoyltransferase mRNA expression, involucrin expression or ATP production by finding substances having excellent activity in promoting epidermal keratinocyte growth, filaggrin mRNA expression, serine palmitoyltransferase mRNA expression, involucrin expression or ATP production.SOLUTION: An epidermal keratinocyte growth promoting agent of the invention comprises one or more effective ingredients selected from the group consisting of 2-ketoglutaric acid, 2-isopropyl malate, inosine 5'-monophosphoric acid, succinic acid, malic acid and pyruvic acid. Also, a filaggrin mRNA expression promotor, a serine palmitoyltransferase mRNA expression promotor, an involucrin expression promotor of the invention comprise, as an effective ingredient, 2-ketoglutaric acid. Further an ATP production promotor of the invention comprises 2-isopropyl malate as an effective ingredient.SELECTED DRAWING: None

A topical composition for treating diabetic skin conditions is disclosed, comprising a non-steroidal, non-comedogenic, and fragrance-free formulation. The composition includes a synergistic blend of emollients, humectants & occlusives for intense moisturization; emulsifying agents for stabilization; moisturizing agents for enhanced hydration; antioxidants for reducing oxidative stress; anti-inflammatory agents for alleviating inflammation; anti-itching agents for relieving the itching; skin conditioners for improved barrier function; Filaggrin improver and agents for stimulating collagen production. The composition provides relief from dry skin, itching, and redness associated with diabetic skin conditions.

The application belongs to the technical field of biotechnology and cosmetics, and discloses a polypeptide with skin barrier repair activity and application thereof. The polypeptide is an enzymatic fragment derived from Bacillus subtilis neutral metalloproteinase A7UAM1, and the amino acid sequence is shown as SEQ ID NO:1. The mutant is a site-directed mutant of the wild-type A7UAM1, and is preferably a H142A / E143A double mutant. Compared with the wild-type enzyme, the proteolytic activity of the polypeptide and the mutant is reduced by greater than or equal to 90%, but the activity of promoting keratinocytes to express filaggrin (FLG) and loricrin (LOR) is not reduced or is significantly improved, and the application realizes the decoupling of the functions of 'gentle exfoliation' and 'active barrier repair'. The polypeptide or the mutant can be applied to the preparation of cosmetics or drugs with the effects of skin barrier repair, anti-sensitivity and anti-photoaging, and is especially suitable for sensitive skin and post-medical aesthetic repair.

The present invention relates generally to the identification and use of a Kangpu tea extract, an alpha-glucan oligosaccharide, or a mixture thereof, which is capable of increasing skin barrier protection, as assessed by increasing the ability of a specific biomarker for cell differentiation, as well as, for example, a Kangpu tea extract, an alpha-glucan oligosaccharide, or a mixture thereof, as well as, for example, a Kangpu tea extract, an alpha-glucan oligosaccharide, or a mixture thereof. Particularly, measurement is carried out through the expression of silk protein and endoprotein. A composition can be used in a method for improving the aesthetic appearance of human skin affected by impairment of skin barrier comprising topically applying thereto a therapeutically effective amount of an active agent wherein the active agent is applied ex vivo to human skin keratinocytes in a cosmetically acceptable vehicle at a concentration of at least 0.45% w / w, and the synthesis of the inner cover protein and / or the silk protein can be increased by more than 40%.

The present invention relates to a pharmaceutical composition for preventing or treating allergic skin diseases or pruritus, and more specifically, to: a pharmaceutical composition for preventing or treating allergic skin diseases or pruritus, the pharmaceutical composition containing ABT-751 or TN-16 as an active ingredient; a cosmetic composition for preventing or improving allergic skin disease or pruritus, the cosmetic composition containing ABT-751 or TN-16 as an active ingredient; and a cosmetic composition for skin moisturization, the cosmetic composition containing ABT-751 or TN-16 as an active ingredient. A composition for preventing, improving, or treating atopic dermatitis according to the present invention was found to effectively increase the expression of filaggrin in skin cells and improve skin barrier function, and thus have the effect of effectively ameliorating or treating the symptoms of allergic skin diseases including atopic dermatitis or pruritus, and have an excellent skin moisturizing effect.

The present application discloses an isolated anti-IL-17RB antibody, or an antigen binding fragment thereof, or a pharmaceutical composition comprising the same, for treating FLG-associated diseases, which is capable of reversing the down-regulation of Th2-driven filaggrin expression, and thus can effectively treat FLG-associated diseases.

To provide a novel agent for promoting the production of filaggrin and / or epidermal hyaluronic acid.SOLUTION: An agent for promoting the production of filaggrin and / or epidermal hyaluronic acid contains at least one compound selected from the group consisting of citronellyl glucoside, citronellyl mannoside, citronellyl galactoside, citronellyl maltoside, citronellyl lactoside, citronellyl sophoroside, and pharmaceutically acceptable salts thereof.SELECTED DRAWING: None

This invention belongs to the field of daily chemical products and discloses a polysaccharide composition that improves skin immunity and strengthens the skin barrier function, as well as its applications. The polysaccharide composition includes Scutellaria baicalensis polysaccharide, Adenophora stricta polysaccharide, and Trametes versicolor polysaccharide. Through the synergistic effect of these three polysaccharides, it can not only reduce the number of mast cells but also increase antimicrobial peptides and filaggrin; increase filaggrin; and decrease monocyte chemotactic protein-1 and interleukin-6, thereby achieving the effects of improving skin immunity, anti-inflammatory and whitening. Furthermore, it can act as a signaling molecule, widely participating in physiological processes such as intercellular ligand-receptor recognition and intercellular signal transduction, reducing the average relative amplification fold of interleukin-6 expression factor mRNA, and effectively participating in epidermal cell differentiation and skin barrier formation, thus strengthening the skin barrier function; it can be used in the preparation of cosmetics.

This invention discloses a cyclic nonapeptide with skin barrier repair and anti-inflammatory effects. The amino acid sequence of the cyclic nonapeptide is: cyclic (arginine-glycine-aspartic acid-serine-arginine-lysine-valine-lysine-tryptophan). The cyclic nonapeptide of this invention can increase the relative expression levels of lobe rhabdominis (LOR), filaggrin (FLG), and aquaporin 3 (AQP3) genes, and reduce the secretion of inflammatory factors IL-6 and IL-8, thereby exhibiting skin barrier repair and anti-inflammatory effects.

The application relates to the cosmetic technical field, and particularly discloses a water-oil balance composition suitable for sensitive skin and application thereof. The components in a suitable mass ratio range are matched with each other, so that the temperature-sensitive receptors of the skin can be synergistically regulated, natural moisturizing production is promoted, and ultraviolet protection is improved. The water-oil balance composition can selectively inhibit TRPV1-mediated 5alpha-reductase activity and ultraviolet-induced oxidative stress under high temperature in summer, accurately regulate sebum secretion without damaging the barrier, and promote the generation of natural moisturizing factors by activating filaggrin degradation in a low-temperature environment in winter, dynamically adjust the hydration degree of the stratum corneum, break through the technical limitations of traditional products, such as seasonal use and single and one-sided functions of active ingredients, realize cross-seasonal balanced care of a single formula, and are mild and non-irritating, and are suitable for sensitive skin.

The present invention relates to delivering benefits related to maintaining a resilient microbiome on skin through a personal care composition, especially through wash off compositions like soap, body wash or shampoo. This is achieved by using starch or its microbial metabolite preferably in such compositions. It works by upregulating expression levels of Aquaporin-3, Claudin 1, Keratin- 4, Filaggrin- 1 or Desmoglein 1 on skin.

The present disclosure relates to a cosmetic composition containing an extract of Cyperus rotundus extracted using warm microbubbles. The extract inhibits nitric oxide (NO) production and exhibits excellent anti-inflammatory efficacy by inhibiting the expression of interleukin 6 (IL-6), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α), which are inflammatory expression factors. In addition, the extract enhances the expression of aquaporin-3 (AQP-3), hyaluronan synthase 2 (HAS-2), claudin-1 (CLDN-1), cadherin 1 (CDH1), filaggrin (FLG), and involucrin (IVL), which are genes related to the skin barrier and moisturizing. Thus, when using the extract for cosmetic products, excellent effects can be exhibited in skin soothing, moisturizing, enhancement of the skin barrier, relief of irritation such as erythema, relief of pruritus, and the like, so the extract can be usefully applied to multi-care products that improve skin conditions.

The present invention relates to an oil-in-water type cosmetic composition in which visible dermacosmetic oil particles carrying skin-beneficial ingredients, such as compounds, peptides, or natural oils having skin regeneration, whitening, or antioxidant effects, are supported. More particularly, the present invention relates to an oil-in-water type cosmetic composition in which visible oil particles constituting an oil phase are dispersed in a continuous aqueous phase, wherein the aqueous phase includes an acrylic polymer and water, the oil phase includes an oil, a gelling agent, and a skin-beneficial ingredient, and the oil is a mixture of two or more oils including a low-viscosity oil and a high-viscosity oil. Utilizing the visible oil particles, the present invention can efficiently deliver the beneficial ingredients into the skin, exhibit various effects, including moisturizing, increased filaggrin production, skin whitening, and enhancement of the skin barrier, and also be applied to skin diseases such as atopic dermatitis and psoriasis. In addition, the composition maintains the stability of the emulsified particles and prevents mixing with other oils even without the use of surfactants or emulsifiers, exhibits low hardness and a low thixotropic index to provide a smooth application to the skin and maximum sensory properties, and offers aesthetic appeal, thereby enabling broad applications not only in cosmetics but also in the pharmaceutical field.

The invention relates to the technical field of preparation methods of cosmetic functional raw materials, in particular to application of a fructus arctii extraction product. The invention provides an application of a fructus arctii extraction product in preparation of a product with the effect of improving skin permeability. Wherein the fructus arctii extraction product is used as a functional component for improving skin permeability; according to the invention, a unique preparation process is adopted, and the active ingredients of phenolic acid and lignan substances are enriched, so that the expression of transglutaminase-1 (TGM1) can be improved; the cuticle cells are more compact, the microstructure is complete and ordered, and release of dirt such as melanin, carboxy methyl lysine (CML) and inflammatory chroma related factors IL-33 in the skin is effectively inhibited. By promoting the expression of fibronectin (FLG), tight junction protein (Claudin-1) and hyaluronic acid (HA), the skin surface is smoother and brighter, and the permeability of the skin is remarkably improved.

This invention belongs to the field of daily chemical products and discloses a polysaccharide composition that improves skin immunity and strengthens the skin barrier function. The polysaccharide composition includes: (1) Scutellaria baicalensis polysaccharide, Adenophora stricta polysaccharide and Trametes versicolor polysaccharide; or (2) Scutellaria baicalensis polysaccharide, Lycium barbarum polysaccharide and Adenophora stricta polysaccharide; through the synergistic effect of the above three polysaccharides, it can not only reduce the number of mast cells, but also increase antimicrobial peptides; increase filaggrin; and reduce monocyte chemotactic protein-1 and interleukin-6, thereby achieving the effects of improving skin immunity, anti-inflammatory and whitening; it can also act as an information molecule to widely participate in physiological processes such as the mutual recognition of intercellular ligands and receptors and intercellular signal transduction, reduce the average relative amplification fold of interleukin-6 expression factor mRNA, and can participate well in the differentiation of epidermal cells and the formation of the skin barrier, thereby strengthening the skin barrier function; it can be used to prepare cosmetics.

To provide a non-therapeutic method for preventing and / or reducing a keratinization disorder, and a composition used in the method.SOLUTION: The invention is directed to the use of ectoine and / or hydroxyectoine for the prevention and / or reduction of keratinization disorders, and to ectoine and / or hydroxyectoine and formulations for use in the prevention and / or reduction of keratinization disorders. The present invention is further directed to the use of ectoine and / or hydroxyectoine as a cosmetic agent for reducing the carbonylization of one or more proteins selected from the group consisting of filaggrin, formelin, LAMP2a and / or filaggrin-2 and / or for upregulating one or more proteins selected from the group consisting of filaggrin, formelin and LAMP2a, and to a cosmetic composition comprising said cosmetic agent.SELECTED DRAWING: None

The present application relates to the field of medical and cosmetic technology, and particularly relates to a multi-target composition for promoting skin water-locking and moisturizing, and a preparation method and medical and cosmetic application thereof. The composition comprises hexapeptide-9, tripeptide-1, carnosine, ergothioneine, kava-kava extract, oat extract, mulberry leaf extract, icodione, glycerol glucoside, sodium hyaluronate, allantoin, butanediol and water. The present application prepares the composition by specific collocation of different raw materials, can promote the generation of filaggrin, tight junction protein and endogenous natural moisturizing factor, enhance the epidermal hydration and skin water-locking and moisturizing effect, promote the expression of water channel protein AQP3, strengthen the water transport in skin (transfer to water-deficient parts) and repair the skin ability. The composition is applied in skin medicine, can accelerate the skin barrier repair; is applied in skin cosmetics, realizes the endogenous water-locking and moisturizing from multi-target, improves the skin barrier, and makes the skin persistent moisturizing, nourishing, full, and elastic.

The application discloses a skin care composition with keratinization envelope repairing effect and application thereof. The skin care composition is prepared by compounding Dendrobium candidum stem extract and / or Glycyrrhiza inflata Bat. extract on the basis of hyaluronic acid lysine copper chelate, and the skin care composition can promote filaggrin (FLG), involucrin (IVL), loricrin (LOR), keratin (KRT1) and keratinocyte transglutaminase (TGM1) protein expression, so that the effect of repairing keratinization envelope is achieved, and the skin care composition can be used for improving skin barrier and redness and other problems in cosmetics.

Provided is an ozone-treated glycerol having an oxidizing power of 10-300 ppm in terms of ozone concentration. The ozone-treated glycerol is characterized by: (1) being an ozone-formed oxide obtained by oxidizing glycerol with ozone for one hour or more; (2) being a polyol dilution obtained by diluting, with a polyol, an ozone-treated glycerol having a high oxidizing power of 1,000 ppm or more in terms of ozone concentration; or (3) having one or more activities that promote the expression of involucrin, the production of filaggrin, the production of LC3-II, or the production of ceramide.

The application belongs to the technical field of cosmetics, and discloses a portulaca oleracea seed oil, a preparation method and application thereof, cosmetics, medicines and food. The portulaca oleracea seed oil comprises, in percentage by mass, 33-37% of linoleic acid, 24-27% of linolenic acid, 15-18% of oleic acid, 14-16% of palmitic acid, 3.5-4.5% of stearic acid, 0.5-1% of isooleic acid and 0.3-0.4% of behenic acid. The portulaca oleracea seed oil prepared by the preparation method of the application can effectively promote the proliferation of immortalized keratinocytes, reduce the production of inflammatory factors, has strong anti-inflammatory effect, can promote the expression of filaggrin and tight junction protein genes and has barrier repair effect. The preparation method of the portulaca oleracea seed oil comprises sequentially drying, seed oil extraction, seed oil purification, decolorization, impurity removal and drying to obtain the portulaca oleracea seed oil, and has the advantages of simple operation, high yield, low cost, stable product quality, green and environment-friendly process and suitability for large-scale production.

This invention relates to a cyclic octapeptide derivative having the structure shown in formula (I) or a salt thereof or a stereoisomer thereof, a method for its preparation, and its applications, wherein each R is independently selected from: C5~C 13 Alkyl, C5~C 13 Unsaturated chain hydrocarbon group. The cyclic octapeptide derivatives or their salts or stereoisomers provided by this invention have good skin permeability, can significantly increase the expression of α-crystallin, filaggrin and hyaluronic acid in epidermal cells, and the effect is significantly better than cyclic tetrapeptide derivatives, and far superior to commercially available linear peptide palmitoyl tetrapeptide-10, which can more effectively repair and enhance the skin barrier, and improve skin smoothness and translucency. Furthermore, the cyclic octapeptide derivatives of this invention achieve high bioactivity while having good stability and safety. (I)

The invention relates to a cyclic octapeptide derivative with a structure as shown in a formula (I), or a salt or a stereoisomer thereof, and a preparation method and application thereof, and in the formula (I), each R is independently selected from C5-C13 alkyl and C5-C13 unsaturated chain alkyl. The cyclic octapeptide derivative or the salt thereof or the stereoisomer thereof provided by the invention has good skin permeability, can significantly improve expression of alpha-crystal protein, silk protein and hyaluronic acid in epidermal cells, and has an effect significantly superior to that of a cyclic tetrapeptide derivative, more significantly far superior to that of a commercially available straight-chain peptide palmitoyl tetrapeptide-10, and has good application prospects. The skin barrier can be effectively repaired and enhanced, and the smoothness and transparency of the skin are improved. Moreover, the cyclic octapeptide derivative disclosed by the invention has good stability and safety while realizing high biological activity. (I).

The present invention relates to a pharmaceutical composition for preventing or treating allergic skin diseases or skin pruritus, and more specifically to a pharmaceutical composition for preventing or treating allergic skin diseases or skin pruritus, which contains ABT-751 or TN-16 as an active ingredient; a cosmetic composition for preventing or ameliorating allergic skin diseases or skin pruritus, which contains ABT-751 or TN-16 as an active ingredient; and a cosmetic composition for moisturizing the skin, which contains ABT-751 or TN-16 as an active ingredient. It has been confirmed that the composition for preventing, ameliorating, and treating atopic dermatitis according to the present invention effectively increases filaggrin expression in skin cells and improves skin barrier function, thereby effectively improving or treating the symptoms of allergic skin diseases including atopic dermatitis or skin pruritus, and also exhibits excellent skin moisturizing effects.