37 results about "Filaggrin" patented technology

The invention relates to a preparation method and application of a sensitive skin repairing composition containing phellinus igniarius PDRN, and belongs to the technical field of cosmetics. The sensitive skin repairing composition is prepared from phellinus medicinus PDRN, bio-saccharide gum-1 and tephrosia esculenta seed extract, and the three components have a synergistic effect and can effectively promote the generation of three barrier proteins, namely tight junction protein, biaprylin and fibroin, so that the skin barrier function is strengthened, the long-acting repairing of sensitive skin is realized, and the skin sensitivity is reduced.

To provide agents for promoting epidermal keratinocyte growth, filaggrin mRNA expression, serine palmitoyltransferase mRNA expression, involucrin expression or ATP production by finding substances having excellent activity in promoting epidermal keratinocyte growth, filaggrin mRNA expression, serine palmitoyltransferase mRNA expression, involucrin expression or ATP production.SOLUTION: An epidermal keratinocyte growth promoting agent of the invention comprises one or more effective ingredients selected from the group consisting of 2-ketoglutaric acid, 2-isopropyl malate, inosine 5'-monophosphoric acid, succinic acid, malic acid and pyruvic acid. Also, a filaggrin mRNA expression promotor, a serine palmitoyltransferase mRNA expression promotor, an involucrin expression promotor of the invention comprise, as an effective ingredient, 2-ketoglutaric acid. Further an ATP production promotor of the invention comprises 2-isopropyl malate as an effective ingredient.SELECTED DRAWING: None

The present invention relates to a polymer self-assembly nanocarrier and a method of preparing same, the nanocarrier binding a peptide that targets a specific cell and, simultaneously, carrying an active ingredient that has been verified. The present invention can exhibit various effects such as a moisturizing effect, an increase in filaggrin production, whitening, skin barrier reinforcement and the like by selectively and efficiently delivering a drug through a targeting peptide, can be applied to skin diseases such as atopy or psoriasis, and is expected to enable the maximum effect of an active substance in the pharmaceutical and cosmetic fields to be obtained.

A topical composition for treating diabetic skin conditions is disclosed, comprising a non-steroidal, non-comedogenic, and fragrance-free formulation. The composition includes a synergistic blend of emollients, humectants & occlusives for intense moisturization; emulsifying agents for stabilization; moisturizing agents for enhanced hydration; antioxidants for reducing oxidative stress; anti-inflammatory agents for alleviating inflammation; anti-itching agents for relieving the itching; skin conditioners for improved barrier function; Filaggrin improver and agents for stimulating collagen production. The composition provides relief from dry skin, itching, and redness associated with diabetic skin conditions.

The application belongs to the technical field of biotechnology and cosmetics, and discloses a polypeptide with skin barrier repair activity and application thereof. The polypeptide is an enzymatic fragment derived from Bacillus subtilis neutral metalloproteinase A7UAM1, and the amino acid sequence is shown as SEQ ID NO:1. The mutant is a site-directed mutant of the wild-type A7UAM1, and is preferably a H142A / E143A double mutant. Compared with the wild-type enzyme, the proteolytic activity of the polypeptide and the mutant is reduced by greater than or equal to 90%, but the activity of promoting keratinocytes to express filaggrin (FLG) and loricrin (LOR) is not reduced or is significantly improved, and the application realizes the decoupling of the functions of 'gentle exfoliation' and 'active barrier repair'. The polypeptide or the mutant can be applied to the preparation of cosmetics or drugs with the effects of skin barrier repair, anti-sensitivity and anti-photoaging, and is especially suitable for sensitive skin and post-medical aesthetic repair.

The present invention relates generally to the identification and use of a Kangpu tea extract, an alpha-glucan oligosaccharide, or a mixture thereof, which is capable of increasing skin barrier protection, as assessed by increasing the ability of a specific biomarker for cell differentiation, as well as, for example, a Kangpu tea extract, an alpha-glucan oligosaccharide, or a mixture thereof, as well as, for example, a Kangpu tea extract, an alpha-glucan oligosaccharide, or a mixture thereof. Particularly, measurement is carried out through the expression of silk protein and endoprotein. A composition can be used in a method for improving the aesthetic appearance of human skin affected by impairment of skin barrier comprising topically applying thereto a therapeutically effective amount of an active agent wherein the active agent is applied ex vivo to human skin keratinocytes in a cosmetically acceptable vehicle at a concentration of at least 0.45% w / w, and the synthesis of the inner cover protein and / or the silk protein can be increased by more than 40%.

The present invention relates to a pharmaceutical composition for preventing or treating allergic skin diseases or pruritus, and more specifically, to: a pharmaceutical composition for preventing or treating allergic skin diseases or pruritus, the pharmaceutical composition containing ABT-751 or TN-16 as an active ingredient; a cosmetic composition for preventing or improving allergic skin disease or pruritus, the cosmetic composition containing ABT-751 or TN-16 as an active ingredient; and a cosmetic composition for skin moisturization, the cosmetic composition containing ABT-751 or TN-16 as an active ingredient. A composition for preventing, improving, or treating atopic dermatitis according to the present invention was found to effectively increase the expression of filaggrin in skin cells and improve skin barrier function, and thus have the effect of effectively ameliorating or treating the symptoms of allergic skin diseases including atopic dermatitis or pruritus, and have an excellent skin moisturizing effect.

The present invention relates to a pharmaceutical composition for preventing or treating allergic skin diseases or skin itch, and more particularly, to a pharmaceutical composition for preventing or treating allergic skin diseases or skin itch, containing ABT-751 or TN-16 as an active ingredient, a cosmetic composition for preventing or ameliorating allergic skin diseases or skin itch, which contains ABT-751 or TN-16 as an active ingredient; and a cosmetic composition for moisturizing skin, which contains ABT-751 or TN-16 as an active ingredient. The composition for preventing or improving and treating atopic dermatitis according to the present invention effectively increases the expression of silk protein in skin cells and improves the skin barrier function, thereby having the effect of effectively improving or treating the symptoms of allergic skin diseases including atopic dermatitis or skin itch. And it is confirmed that an excellent skin moisturizing effect is exhibited.

The invention discloses a new application of isopentadecanoic acid, and discloses an application of isopentadecanoic acid in preparation of skin care cosmetics, isopentadecanoic acid has the effects of up-regulating expression of hBD-2 and silk protein in human immortalized keratinocytes, reducing expression synthesis of ROS and TRPV1 in the human immortalized keratinocytes, inhibiting release of NO by mouse macrophages, and inhibiting expression of the human immortalized keratinocytes. And the secretion of sebaceous gland cell grease is reduced.

The present application discloses an isolated anti-IL-17RB antibody, or an antigen binding fragment thereof, or a pharmaceutical composition comprising the same, for treating FLG-associated diseases, which is capable of reversing the down-regulation of Th2-driven filaggrin expression, and thus can effectively treat FLG-associated diseases.

To provide a novel agent for promoting the production of filaggrin and / or epidermal hyaluronic acid.SOLUTION: An agent for promoting the production of filaggrin and / or epidermal hyaluronic acid contains at least one compound selected from the group consisting of citronellyl glucoside, citronellyl mannoside, citronellyl galactoside, citronellyl maltoside, citronellyl lactoside, citronellyl sophoroside, and pharmaceutically acceptable salts thereof.SELECTED DRAWING: None

The present invention relates to a novel pseudo-ceramide compound and a method for preparing same, the compound being represented by chemical formula 1. The pseudo-ceramide of the present invention not only has a moisturizing effect, increased filaggrin production, and an anti-inflammatory effect, but also has a simple and economical synthesis process, and is suitable for use in a topical dermatologic composition for skin moisturization and cosmetic applications. [Chemical Formula 1] wherein A* is hydrogen or an acyl group of a C7-C16 saturated or unsaturated aliphatic chain, which is unsubstituted or substituted with a hydroxyl group, R1 is a C7-C15 saturated or unsaturated aliphatic chain which is unsubstituted or substituted with a hydroxyl group, and the difference in the number of carbon atoms between A* and R1 is at least 7.

This invention belongs to the field of daily chemical products and discloses a polysaccharide composition that improves skin immunity and strengthens the skin barrier function, as well as its applications. The polysaccharide composition includes Scutellaria baicalensis polysaccharide, Adenophora stricta polysaccharide, and Trametes versicolor polysaccharide. Through the synergistic effect of these three polysaccharides, it can not only reduce the number of mast cells but also increase antimicrobial peptides and filaggrin; increase filaggrin; and decrease monocyte chemotactic protein-1 and interleukin-6, thereby achieving the effects of improving skin immunity, anti-inflammatory and whitening. Furthermore, it can act as a signaling molecule, widely participating in physiological processes such as intercellular ligand-receptor recognition and intercellular signal transduction, reducing the average relative amplification fold of interleukin-6 expression factor mRNA, and effectively participating in epidermal cell differentiation and skin barrier formation, thus strengthening the skin barrier function; it can be used in the preparation of cosmetics.

This invention discloses a cyclic nonapeptide with skin barrier repair and anti-inflammatory effects. The amino acid sequence of the cyclic nonapeptide is: cyclic (arginine-glycine-aspartic acid-serine-arginine-lysine-valine-lysine-tryptophan). The cyclic nonapeptide of this invention can increase the relative expression levels of lobe rhabdominis (LOR), filaggrin (FLG), and aquaporin 3 (AQP3) genes, and reduce the secretion of inflammatory factors IL-6 and IL-8, thereby exhibiting skin barrier repair and anti-inflammatory effects.

The present invention belongs to the field of bioengineering, and particularly relates to a recombinant humanized filaggrin with good moisturizing effect, a preparation method thereof, and an application thereof. By screening different fragments of natural filaggrin and expressing recombinant humanized filaggrin FLG using Escherichia coli, the present invention successfully prepares a recombinant humanized filaggrin FLG with good moisturizing effect, and its amino acid sequence is selected from one of SEQ ID NO.11, SEQ ID NO.12, SEQ ID NO.13, SEQ ID NO.14, and SEQ ID NO.15. It has been proven by experiments that the recombinant humanized filaggrin prepared by the present invention not only has good cell adhesion and cell migration activities, but also has good actual moisturizing experimental effects when applied to the human body, and has good practical application value.

The application relates to the cosmetic technical field, and particularly discloses a water-oil balance composition suitable for sensitive skin and application thereof. The components in a suitable mass ratio range are matched with each other, so that the temperature-sensitive receptors of the skin can be synergistically regulated, natural moisturizing production is promoted, and ultraviolet protection is improved. The water-oil balance composition can selectively inhibit TRPV1-mediated 5alpha-reductase activity and ultraviolet-induced oxidative stress under high temperature in summer, accurately regulate sebum secretion without damaging the barrier, and promote the generation of natural moisturizing factors by activating filaggrin degradation in a low-temperature environment in winter, dynamically adjust the hydration degree of the stratum corneum, break through the technical limitations of traditional products, such as seasonal use and single and one-sided functions of active ingredients, realize cross-seasonal balanced care of a single formula, and are mild and non-irritating, and are suitable for sensitive skin.

The present invention relates to delivering benefits related to maintaining a resilient microbiome on skin through a personal care composition, especially through wash off compositions like soap, body wash or shampoo. This is achieved by using starch or its microbial metabolite preferably in such compositions. It works by upregulating expression levels of Aquaporin-3, Claudin 1, Keratin- 4, Filaggrin- 1 or Desmoglein 1 on skin.

The invention discloses a composition for turning white hair into black hair and application of the composition. The composition for turning the white hair into the black hair is prepared from the following components in parts by mass: 1.5 to 5.0 parts of hydroxyethyl piperazine ethanesulfonic acid, 0.5 to 3.5 parts of arginine, 40.0 to 80.0 parts of glycoprotein, 24.0 to 40.0 parts of hydroxyferriheme and 0.1 to 0.6 part of vitamin C, the composition disclosed by the invention can penetrate into hair follicles to play a role, activate a plurality of MITF pathways in melanocytes in the hair follicles, induce melanin, an antioxidant and a stem cell protection factor generation receptor to react, effectively promote the function of the melanocytes, and effectively promote white hair to become black hair for a long time. Meanwhile, the composition for turning the white hair into the black hair can promote generation of fibroin of keratinocytes, scalp barrier repairing is achieved, and the combing performance of the hair and the brightness of the hair can be improved.

The present disclosure relates to a cosmetic composition containing an extract of Cyperus rotundus extracted using warm microbubbles. The extract inhibits nitric oxide (NO) production and exhibits excellent anti-inflammatory efficacy by inhibiting the expression of interleukin 6 (IL-6), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α), which are inflammatory expression factors. In addition, the extract enhances the expression of aquaporin-3 (AQP-3), hyaluronan synthase 2 (HAS-2), claudin-1 (CLDN-1), cadherin 1 (CDH1), filaggrin (FLG), and involucrin (IVL), which are genes related to the skin barrier and moisturizing. Thus, when using the extract for cosmetic products, excellent effects can be exhibited in skin soothing, moisturizing, enhancement of the skin barrier, relief of irritation such as erythema, relief of pruritus, and the like, so the extract can be usefully applied to multi-care products that improve skin conditions.

The present invention relates to an oil-in-water type cosmetic composition in which visible dermacosmetic oil particles carrying skin-beneficial ingredients, such as compounds, peptides, or natural oils having skin regeneration, whitening, or antioxidant effects, are supported. More particularly, the present invention relates to an oil-in-water type cosmetic composition in which visible oil particles constituting an oil phase are dispersed in a continuous aqueous phase, wherein the aqueous phase includes an acrylic polymer and water, the oil phase includes an oil, a gelling agent, and a skin-beneficial ingredient, and the oil is a mixture of two or more oils including a low-viscosity oil and a high-viscosity oil. Utilizing the visible oil particles, the present invention can efficiently deliver the beneficial ingredients into the skin, exhibit various effects, including moisturizing, increased filaggrin production, skin whitening, and enhancement of the skin barrier, and also be applied to skin diseases such as atopic dermatitis and psoriasis. In addition, the composition maintains the stability of the emulsified particles and prevents mixing with other oils even without the use of surfactants or emulsifiers, exhibits low hardness and a low thixotropic index to provide a smooth application to the skin and maximum sensory properties, and offers aesthetic appeal, thereby enabling broad applications not only in cosmetics but also in the pharmaceutical field.

The invention relates to the technical field of preparation methods of cosmetic functional raw materials, in particular to application of a fructus arctii extraction product. The invention provides an application of a fructus arctii extraction product in preparation of a product with the effect of improving skin permeability. Wherein the fructus arctii extraction product is used as a functional component for improving skin permeability; according to the invention, a unique preparation process is adopted, and the active ingredients of phenolic acid and lignan substances are enriched, so that the expression of transglutaminase-1 (TGM1) can be improved; the cuticle cells are more compact, the microstructure is complete and ordered, and release of dirt such as melanin, carboxy methyl lysine (CML) and inflammatory chroma related factors IL-33 in the skin is effectively inhibited. By promoting the expression of fibronectin (FLG), tight junction protein (Claudin-1) and hyaluronic acid (HA), the skin surface is smoother and brighter, and the permeability of the skin is remarkably improved.

This invention belongs to the field of daily chemical products and discloses a polysaccharide composition that improves skin immunity and strengthens the skin barrier function. The polysaccharide composition includes: (1) Scutellaria baicalensis polysaccharide, Adenophora stricta polysaccharide and Trametes versicolor polysaccharide; or (2) Scutellaria baicalensis polysaccharide, Lycium barbarum polysaccharide and Adenophora stricta polysaccharide; through the synergistic effect of the above three polysaccharides, it can not only reduce the number of mast cells, but also increase antimicrobial peptides; increase filaggrin; and reduce monocyte chemotactic protein-1 and interleukin-6, thereby achieving the effects of improving skin immunity, anti-inflammatory and whitening; it can also act as an information molecule to widely participate in physiological processes such as the mutual recognition of intercellular ligands and receptors and intercellular signal transduction, reduce the average relative amplification fold of interleukin-6 expression factor mRNA, and can participate well in the differentiation of epidermal cells and the formation of the skin barrier, thereby strengthening the skin barrier function; it can be used to prepare cosmetics.

To provide a non-therapeutic method for preventing and / or reducing a keratinization disorder, and a composition used in the method.SOLUTION: The invention is directed to the use of ectoine and / or hydroxyectoine for the prevention and / or reduction of keratinization disorders, and to ectoine and / or hydroxyectoine and formulations for use in the prevention and / or reduction of keratinization disorders. The present invention is further directed to the use of ectoine and / or hydroxyectoine as a cosmetic agent for reducing the carbonylization of one or more proteins selected from the group consisting of filaggrin, formelin, LAMP2a and / or filaggrin-2 and / or for upregulating one or more proteins selected from the group consisting of filaggrin, formelin and LAMP2a, and to a cosmetic composition comprising said cosmetic agent.SELECTED DRAWING: None

The present application relates to the field of medical and cosmetic technology, and particularly relates to a multi-target composition for promoting skin water-locking and moisturizing, and a preparation method and medical and cosmetic application thereof. The composition comprises hexapeptide-9, tripeptide-1, carnosine, ergothioneine, kava-kava extract, oat extract, mulberry leaf extract, icodione, glycerol glucoside, sodium hyaluronate, allantoin, butanediol and water. The present application prepares the composition by specific collocation of different raw materials, can promote the generation of filaggrin, tight junction protein and endogenous natural moisturizing factor, enhance the epidermal hydration and skin water-locking and moisturizing effect, promote the expression of water channel protein AQP3, strengthen the water transport in skin (transfer to water-deficient parts) and repair the skin ability. The composition is applied in skin medicine, can accelerate the skin barrier repair; is applied in skin cosmetics, realizes the endogenous water-locking and moisturizing from multi-target, improves the skin barrier, and makes the skin persistent moisturizing, nourishing, full, and elastic.

The application discloses a skin care composition with keratinization envelope repairing effect and application thereof. The skin care composition is prepared by compounding Dendrobium candidum stem extract and / or Glycyrrhiza inflata Bat. extract on the basis of hyaluronic acid lysine copper chelate, and the skin care composition can promote filaggrin (FLG), involucrin (IVL), loricrin (LOR), keratin (KRT1) and keratinocyte transglutaminase (TGM1) protein expression, so that the effect of repairing keratinization envelope is achieved, and the skin care composition can be used for improving skin barrier and redness and other problems in cosmetics.

Described herein are methods and compositions for the treatment of Alzheimer's Disease (AD), as well as compositions comprising winder-derived peptides and methods of use thereof.

Provided is an ozone-treated glycerol having an oxidizing power of 10-300 ppm in terms of ozone concentration. The ozone-treated glycerol is characterized by: (1) being an ozone-formed oxide obtained by oxidizing glycerol with ozone for one hour or more; (2) being a polyol dilution obtained by diluting, with a polyol, an ozone-treated glycerol having a high oxidizing power of 1,000 ppm or more in terms of ozone concentration; or (3) having one or more activities that promote the expression of involucrin, the production of filaggrin, the production of LC3-II, or the production of ceramide.

The application belongs to the technical field of cosmetics, and discloses a portulaca oleracea seed oil, a preparation method and application thereof, cosmetics, medicines and food. The portulaca oleracea seed oil comprises, in percentage by mass, 33-37% of linoleic acid, 24-27% of linolenic acid, 15-18% of oleic acid, 14-16% of palmitic acid, 3.5-4.5% of stearic acid, 0.5-1% of isooleic acid and 0.3-0.4% of behenic acid. The portulaca oleracea seed oil prepared by the preparation method of the application can effectively promote the proliferation of immortalized keratinocytes, reduce the production of inflammatory factors, has strong anti-inflammatory effect, can promote the expression of filaggrin and tight junction protein genes and has barrier repair effect. The preparation method of the portulaca oleracea seed oil comprises sequentially drying, seed oil extraction, seed oil purification, decolorization, impurity removal and drying to obtain the portulaca oleracea seed oil, and has the advantages of simple operation, high yield, low cost, stable product quality, green and environment-friendly process and suitability for large-scale production.

This invention relates to a cyclic octapeptide derivative having the structure shown in formula (I) or a salt thereof or a stereoisomer thereof, a method for its preparation, and its applications, wherein each R is independently selected from: C5~C 13 Alkyl, C5~C 13 Unsaturated chain hydrocarbon group. The cyclic octapeptide derivatives or their salts or stereoisomers provided by this invention have good skin permeability, can significantly increase the expression of α-crystallin, filaggrin and hyaluronic acid in epidermal cells, and the effect is significantly better than cyclic tetrapeptide derivatives, and far superior to commercially available linear peptide palmitoyl tetrapeptide-10, which can more effectively repair and enhance the skin barrier, and improve skin smoothness and translucency. Furthermore, the cyclic octapeptide derivatives of this invention achieve high bioactivity while having good stability and safety. (I)

The invention relates to a repair patch targeting propionibacterium acnes and improving acne muscles and a preparation method thereof, and belongs to the technical field of cosmetics. The invention discloses a repair composition with effects of targeting propionibacterium acnes and improving pox muscles, and a repair patch prepared by taking the repair composition as a main component can be randomly cut to obtain the repair patch with targeted inhibition of propionibacterium acnes and a fixed-point repair effect. The repair patch is prepared by carrying royal jelly acid lipidosome and fig extract, mixing pullulan and sugar alcohol, dissolving and drying. Through in-vitro evaluation, the repair patch can inhibit the growth of acne-causing propionibacterium acnes; the repair patch carries the royal jelly acid liposome and the fig extract, can promote the expression of keratinocyte fibronectin and kyllingin, and synergistically enhances the skin barrier; a human body evaluation test shows that the repairing patch can remarkably improve acne skin and reduce the red area caused by acnes.