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358 results about "Inosine" patented technology
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Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N₉-glycosidic bond. Inosine is commonly found in tRNAs and is essential for proper translation of the genetic code in wobble base pairs.
CPG-like nucleic acids and methods of use thereof
InactiveUS20080226649A1Enhancing neutrophil proliferationOrganic active ingredientsSugar derivativesAllergyPurine
Immunostimulatory compositions described as CpG-like nucleic acids are provided, including nucleic acids having immunostimulatory characteristics of CpG nucleic acid, despite certain substitutions of C, G, or C and G of the CpG dinucleotide. The substitutions can include, among others, exchange of methylated C for C, inosine for G, and ZpY for CpG, where Z is cytosine or dSpacer and Y is inosine, 2-aminopurine, nebularine, or dSpacer. Also provided are methods for inducing an immune response in a subject using the CpG-like nucleic acids. The methods are useful in the treatment of a subject that has or is at risk of developing an infectious disease, allergy, asthma, cancer, anemia, thrombocytopenia, or neutropenia.
Owner:COLEY PHARMA GMBH
Oligonucleotide comprising an inosine for treating dmd
InactiveUS20120046342A1Avoid or decrease a potential multimerisation or aggregation of oligonucleotidesLow efficiencyOrganic active ingredientsSplicing alterationInosineNucleotide
The invention provides an oligonucleotide comprising an inosine, and / or a nucleotide containing a base able to form a wobble base pair or a functional equivalent thereof, wherein the oligonucleotide, or a functional equivalent thereof, comprises a sequence which is complementary to at least part of a dystrophin pre-m RNA exon or at least part of a non-exon region of a dystrophin pre-m RNA said part being a contiguous stretch comprising at least 8 nucleotides. The invention further provides the use of said oligonucleotide for preventing or treating DMD or BMD.
Owner:BIOMARIN TECH BV
Adenosine receptor agonists for the promotion of wound healing
Agonists of the adenosine A2 receptor promote the migration of endothelial cells, fibroblasts and epithelial cells. Thus, methods and pharmaceutical compositions useful for treating wounds and promoting wound healing comprise agents which cause stimulation of the adenosine A2 receptor, preferably receptor agonists and adenosine uptake blockers. Preferred agonists include 2-phenylaminoadenosine, 2-para-2-carboxyethylphenyl-amino-5'N-ethylcarboxamidoadenosine, 5'N-ethylcarbox-amidoadenosine, 5'N-cyclo-propyladenosine, 5'N-methylcarboxamidoadenosine and PD-125944. Preferred uptake blockers include dipyridamole, nitrobenzylthio-inosine, dilazep and R75231.
Owner:NEW YORK UNIV
Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases
InactiveUS6841561B1Potent activityBiocideOrganic chemistryDiseaseDihydroorotate Dehydrogenase Inhibitor
Flavivirus, rhabdovirus and paramyxovirus infections may be treated by administering an inhibitor of the enzyme dihydroorotate dehydrogenase such as 6-fluoro-2-(2′-fluoro-1,1′-biphenyl-4-yl)-3-methyl-4-quinolinearcarboxylic acid sodium salt (Brequinar). A synergistic effect can be obtained if an interferon such as interferon α2, interferon α8 or interferon β, or an inhibitor of a second enzyme selected from inosine monophosphate dehydrogenase, guanosine monophosphate synthetase, cytidine triphosphate synthetase and S-adenosylhomocysteine hydrolase, is also administered.
Owner:INST OF MOLECULAR & CELL BIOLOGY
Method for extending the useful shelf-life of refrigerated red blood cells by nutrient supplementation
InactiveUS20030153074A1Useful shelf life can be extendedProlong lifeDead animal preservationMammal material medical ingredientsInosineFrozen erythrocytes
There is provided methods and compositions for the storage of red blood cells. The compositions are metabolic supplements which are preferably added to refrigerated red blood cells suspended in an additive solution. Red blood cells are preferably stored under conditions of oxygen-depletion. Metabolic compositions comprises pyruvate, inosine, adenine, and optionally dibasic sodium phosphate and / or monobasic sodium phosphate.
Owner:TRUSTEES OF BOSTON UNIV +1
Peptide conjugated, inosine-substituted antisense oligomer compound and method
InactiveUS20050288246A1Enhancing the cellular uptakeImprove compoundSpecial deliveryAntiviralsBase JCytosine
A therapeutic oligomer-peptide conjugate, and methods of using the conjugate are disclosed. The conjugate includes (a) a substantially uncharged oligonucleotide analog compound having a base sequence that includes a string of bases that are complementary to four or more contiguous cytosine bases in a target nucleic acid region to which the compound is intended to bind, and (b) conjugated to the compound, an arginine-rich peptide effective to enhance the uptake of the compound into target cells. The string of bases in the compound includes at least one inosine base positioned in the string so as to limit the number of contiguous guanine bases in said string to three or fewer. The conjugate has greater cellular uptake than the compound alone, by virtue of the arginine-rich peptide, and substantially greater antisense activity greater activity than the conjugate in the absence of inosine-for guanine substitutions.
Owner:SAREPTA THERAPEUTICS INC
Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
The present invention relates generally to pharmaceutical compositions useful to treat viral diseases. The present invention relates particularly RNA polymerase inhibitors and inosine monophosphate dehydrogenase (IMPDH) inhibitors such as mycophenolate compounds.
Owner:BIOCRYST PHARM INC
Methods and compositions for treating ocular disorders
InactiveUS6855690B2Preventing and treating damageDamage of in useOrganic active ingredientsSenses disorderInosineOptic nerve
The present invention provides a method for treating and / or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and / or inosine.
Owner:CHILDRENS MEDICAL CENT CORP
Method for Producing Purine Nucleosides and Nucleotides by Fermentation Using Bacterium Belonging to the Genus Bacillus or Escherichia
Methods for producing purine nucleosides, and purine nucleotides, such as inosine and 5′-inosinic acid are provided which include using a bacterium belonging to the genus Bacillus or to the genus Escherichia wherein the purine nucleoside productivity of said bacterium is enhanced by increasing an activity of the YdhL protein. Also disclosed is the amino acid sequence of the YdhL protein from Bacillus amyloliquefaciens and the gene encoding it.
Owner:AJINOMOTO CO INC
Isothermal DNA amplification
Provided herein are nucleic acid synthesis methods and agents that employ an endonuclease for example, endonuclease V, to introduce a nick into a target DNA including one or more inosine, and uses a DNA polymerase to generate amplicons of the target DNA.
Owner:GLOBAL LIFE SCI SOLUTIONS OPERATIONS UK LTD
Array-based translocation and rearrangement assays
Methods for detecting genomic rearrangements are provided. In one embodiment, methods are provided for the use of paired end tags from restriction fragments to detect genomic rearrangements. Sequences from the ends of the fragments are brought together to form ditags and the ditags are detected. Combinations of ditags are detected by an on-chip sequencing strategy that is described herein, using inosine for de novo sequencing of short segments of DNA. In another aspect, translocations are identified by using target specific capture and analysis of the captured products on a tiling array.
Owner:AFFYMETRIX INC
Isothermal DNA amplification
Provided herein are nucleic acid synthesis methods and agents that employ an endonuclease for example, endonuclease V, to introduce a nick into a target DNA including one or more inosine, and uses a DNA polymerase to generate amplicons of the target DNA.
Owner:GLOBAL LIFE SCI SOLUTIONS OPERATIONS UK LTD
Preparation method of capecitabine and intermediate thereof
InactiveCN101993463AAdequate responseHigh yieldSugar derivativesSugar derivatives preparationInosineIodine
The invention relates to a preparation method of capecitabine and an intermediate thereof. The material conversion rate is high with less side reaction under the condition that bicarbonate is used as alkali by changing the reaction condition of synthesizing a compound of a formula I by a 5'-deoxidized-5-gemcitabine derivative and chloroformic acid n-amyl ester. Meanwhile, the applicant researches and finds that: Since 5-deoxidized-tri-O-acetyl-D-ribose prepared by using inosine reactrion substituted by iodine and protected by hydroxyl is adopted, the post-treatment process is simplified, and the yield is improved. The 5-deoxidized-tri-O-acetyl-D-ribose is a material for synthesizing the compound of the formula I while the compound of the formula I is a significant intermediate of capecitabine. The whole capecitabine synthesis process has high yield and low cost.
Owner:CHENGDU KANGHONG PHARMA GRP
Freeze drying protective agent for rubricyte and use method in freeze drying process
InactiveCN101368172AImprove recovery rateDead animal preservationTissue cultureHydroxyethyl starchFreeze-drying
The invention relates to a rythrocyte lyophilized protective agent and a using method thereof during lyophilizing. The prescription of the protective agent before being lyophilized is as follows: glucose solution, adenine, NaCl, mannitol, KCl, polymer hydroxyethyl starch, bovine serum albumin and sodium citrate. The prescription of the lyophilized rehydration protective agents is as follows: trehalose, ascorbic acid, NaCl, KH2PO4, Na2 HPO4, dextran, bovine serum albumin, KCl, inosine and adenine. The protective liquid before being lyophilized and rythrocyte suspension liquid are mixed according to the volume ratio of 4:1, are frozen and dried to obtain lyophilized rythrocyte, then the lyophilized rythrocyte is rehydrated by the rehydration protective agent. The recovery rate of the rythrocyte lyophilized protective agent and the using method thereof during lyophilizing of the invention can reach as high as 71.1 percent through the measurement of a cell counter, and is improved by 12.3 percent by comparing with the lyophilized protective agent and the lyophilized method thereof in the prior art, the highest recovery rate of which is 58.5 percent.
Owner:UNIV OF SHANGHAI FOR SCI & TECH
Preparation method of bacillus subtilis wettable powder
ActiveCN105432667AReduce exposureReduce the chance of germinationBiocideDead animal preservationSpore germinationPlant disease
The invention relates to the fields of biological pesticide and microbial fertilizer, and specifically discloses a bacillus subtilis wettable powder containing spore germinator and a preparation method thereof. The wettable powder is composed of the following raw materials in parts by weight: 40 to 70 parts of bacillus subtilis fermentation broth, 20 to 30 parts of filling material (diatomite), 1 to 4 parts of wetting agent (Morwet EFW), 0.2 to 1 part of dispersant (CMC-Na), spore germinator: 0.1 to 0.5 part of L-alanine, 0.1 to 0.5 part of inosine, and 0.5 to 1.5 parts of fructose; UV protector: 0.5 to 2 parts of ascorbic acid, and 0.2 to 1 part of lecithin; dryness protector: 1 to 4 parts of maltose and 0.2 to 1 part of methylcellulose, and 1 to 2 parts of synergist (amino oligosaccharin). After the prepared bacillus subtilis wettable powder is applied to the fields, the spore germination speed is accelerated, the germination rate is high, the fertilizing effect and the plant disease control effect are both prominently improved, the using amount of spores is reduced, and the cost is reduced.
Owner:广西南宁晴空万里环保科技有限公司
Erythrocyte preservative solution
ActiveCN105028389APrevent invasionProtect normal metabolismDead animal preservationBiological testingAntigenInosine
The invention provides an erythrocyte preservative solution. The solution comprises the following components by content: 0.3-0.5g / L of adenine, 25-35g / L of glucose, 6-10g / L of sodium citrate, 0.2-0.4g / L of inosine, 0.2-0.3g / L of chloramphenicol, 0.08-0.12g / L of neomycin sulfate, 2.5-3.5g / L of sodium chloride and 0.04-0.06g / L of sodium dihydrogen phosphate. According to the preservative solution, the preservation period of erythrocytes can be 14 weeks, and the erythrocyte suspension preserved in the solution has a relatively high antigen titer in the preservation period.
Owner:苏州苏大赛尔免疫生物技术有限公司
Inosine derivatives and production methods therefor
The present invention provides a method for producing an inosine derivative represented by the following general formula (1) including the steps of subjecting an inosine derivative of general formula (3) to dithiocarbonylation and carrying out radical reduction of the obtained compound. According to the present invention there can be produced compounds useful as anti-AIDS drugs on industrial scale. wherein R1 may be the same or different and are each benzyl group, benzhydryl group or trityl group, each of which may have a substituent in general formulas (1) and (3).
Owner:AJINOMOTO CO INC
A kind of preparation method of ribavirin
ActiveCN102286046ARaise the level of industrial productionLow market priceSugar derivativesSugar derivatives preparationInosineAlcohol
The invention discloses a preparation method of ribavirin, comprising the following steps: A, by taking inosine as a raw material, adding acid and a catalyst I for acylation reaction to generate ribofuranose tetraacetate; B, respectively treating the ribofuranose tetraacetate obtained in the step A and 1,2,4-triazole-3-carboxylic acid methyl ester by using active carbon firstly, then uniformly mixing the ribofuranose tetraacetate and the 1,2,4-triazole-3-carboxylic acid methyl ester, and then adding a catalyst II for condensation reaction to obtain a condensation compound; C, subjecting the condensation compound obtained in the step B to ammonolysis in ammonia and methyl alcohol to generate crude ribavirin; and D, carrying out refinement on the crude ribavirin obtained in the step C to obtain pure ribavirin. The method is simple in operation, good in selectivity, clean and environment friendly and high in yield of ribavirin.
Owner:STAR LAKE BIOSCI CO INC ZHAOQING GUANGDONG
Method for separating and purifying four nucleoside chemical ingredients from trichosanthes bark
ActiveCN103304613ASimple compositionNot pollutedSugar derivativesChemical recyclingPharmacologyChinese herbology
The invention relates to a method for separating and purifying four nucleoside chemical ingredients (namely adenine, guanosine, 6-iso inosine and adenosine) from traditional Chinese medicine trichosanthes bark. According to the method, four high-purity monomeric compounds, namely adenine, guanosine, 6-iso inosine and adenosine, are obtained from the trichosanthes bark through the following steps of: (1) preparing a crude trichosanthes bark extract; (2) carrying out crude separation by using a macroporous adsorption resin column; and (3) carrying out separation and purification by using semi-preparative high-performance liquid chromatography: carrying out separation and purification on obtained samples by using the semi-preparative high-performance liquid chromatography, wherein the mobile phase is methanol-water. The method disclosed by the invention has the advantages that the process flow is environment-friendly, the damage to the environment is not serious, and the comprehensive cost is low.
Owner:SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE +2
Pharmaceutical composition for treating hepatic fibrosis and preparation method thereof
ActiveCN103550242AQuality improvementConvenient for clinical operationOrganic active ingredientsDigestive systemDiseaseInosine
The invention relates to a pharmaceutical composition for treating hepatic fibrosis and a preparation method thereof. The pharmaceutical composition is a formulation prepared from a main ingredient and pharmaceutically acceptable auxiliary materials, wherein the main ingredient comprises 100-300 parts of pirfenidone and 50-150 parts of inosine. The formulation of pirfenidone and inosine is stable in quality, controllable, safe and effective. In clinic, the formulation is mainly used for the treatment of diseases of hepatic fibrosis, cirrhosis, liver cancer, and the like.
Owner:SICHUAN GUOKANG PHARMA
Anti-alopecia composition and application thereof in preparation of anti-alopecia personal care products
ActiveCN110123659ASignificant germinal effectReduced amount of hair lossCosmetic preparationsHair cosmeticsInosineHair follicle
The invention discloses an anti-alopecia composition and application thereof in preparation of anti-alopecia personal care products. The anti-alopecia composition comprises inosine, lupine hydrolyzedprotein and caffeine in a mass ratio of 1:(1-20):(1-5). The anti-alopecia composition has a remarkable anti-alopecia effect due to the cooperative use of the inosine, the lupine hydrolyzed protein andthe caffeine; the composition also has a hair growth promoting effect, wherein the principle is that hair follicle cells on the scalp are simulated to make the hair follicle cells in the period of dormancy regrow and the number of hair follicles in the growth period is increased to achieve the hair growth effect.
Owner:MINGCHEN HEALTH CO LTD
Adsorbent, cleansing agent, renal disease drug, and functional food
InactiveUS20110135561A1Increase valueImprove functionalityCarbon compoundsAntinoxious agentsPorous carbonTryptophan
Disclosed is an adsorbent including a porous carbon material which is produced from a plant-derived material having a silicon (Si) content of not less than 5 wt. % and which has a value of specific surface area determined by the nitrogen BET method of not less than 10 m2 / g, a silicon content of not more than 1 wt. %, and pore volumes determined by the BJH method and the MP method of not less than 0.1 cm3 / g. The adsorbent adsorbs indole, uric acid, adenosine, α-amylase, 3-methylindole, tryptophan, indicant, theophylline, inosine 5-monophosphate disodium salt, adenosine 5-triphosphate disodium salt, a fatty acid, a coloring matter, hydrophobic molecules, or an organic matter (for example, organic molecules or a protein) having a number average molecular weight of not less than 1×102 and less than 5×102.
Owner:SONY CORP
Process for preparing antivirus medicine 'Libaweilin'
InactiveCN1368553ALow costShort fermentation cycleFermentationDipotassium hydrogen phosphateAntiviral drug
A process for preparing an antiviral medicine "Libaweilin" uses acetyl bacillus brevis ATCC 39311, with starch, peptone, beef paste, sodium chloride, dipotassium hydrogen phosphate, potassium bihydrogen phosphate, defoaming agent and running water as raw materials, and includes fermenting, and synthesis by using the resultant complete bacteria as enzyme source and the inosine as ribosome doner. Its advantages are simple process, low cost and high output rate.
Owner:WUHAN UNIV
Methods and compositions for treating ocular disorders
The present invention provides a method for treating and / or preventing damage to a retina or optic nerve in a subject comprising administering to the subject a therapeutically effective amount of oncomodulin. Preferably, the subject is a mammal, most preferably, a human. In preferred embodiments, the oncomodulin may be used in combination with mannose, a mannose derivative and / or inosine.
Owner:CHILDRENS MEDICAL CENT CORP
Inosine compounds and their use for treating or preventing an inflammation or reperfusion disease
Owner:INOTECK PHARMA CORP
Pharmaceutical composition for treating hepatic fibrosis and preparation method thereof
The invention relates to a pharmaceutical composition for treating hepatic fibrosis and a preparation method thereof. The pharmaceutical composition is a formulation prepared from a main ingredient and pharmaceutically acceptable auxiliary materials, wherein the main ingredient comprises 100-300 parts of pirfenidone and 50-150 parts of inosine. The formulation of pirfenidone and inosine is stable in quality, controllable, safe and effective. In clinic, the formulation is mainly used for the treatment of diseases of hepatic fibrosis, cirrhosis, liver cancer, and the like.
Owner:SICHUAN GUOKANG PHARMA
Cordyceps liquor and method of producing the same
The invention discloses a worm grass wine and preparation process, wherein, the worm grass wine belongs to the health medicine wine. The preparation process includes that: the worm grasses are bred in various wine containers through artificial fungus inoculation and moss silk reproduction by taking advantage of artificial broth bases, and then are added with wine to produce the worm grass wine. The worm grass wine includes 21 trace elements, a plurality of vitamins, cordycepin, cordycepicacid (d-mannitol), SOD enzyme, nucleic acid derivatives, uracil, adenine, inosine and ergo-sterol, and the content of the protein is 1.6 times that of the worm grasses. The worm grass wine can keep the worm grasses fresh, ensures the nourishment is not destructed and lost; moreover, the formation of the worm glass wine is beautiful and vivid like living creatures in the water due to the fact that the worm glass wine is bred in wine bottles through artificial broth bases with high values of medicine, appreciation, collection and so on.
Owner:张笑容
Kit for isothermal DNA amplification starting from an RNA template
A method of amplifying RNA template is provided. The method comprises reverse-transcribing a ribonucleic acid (RNA) template to form a cDNA using a first reaction mixture comprising RNA template, at least one primer capable of hybridizing to the RNA template, a reverse transcriptase and deoxynucleoside triphosphates (dNTPs); and amplifying the cDNA to form an amplified product using a second reaction mixture comprising at least one strand displacement DNA polymerase, at least one inosine-containing primer and a nuclease that is capable of nicking DNA 3' to an inosine residue of the primer. The method is accomplished under an isothermal condition without denaturing the cDNA template. A method of quantifying RNA template in a sample and a method of detecting RNA template in a sample are also provided. Kits for amplifying deoxynucleic acid (DNA) from ribonucleic acid (RNA) template are also provided.
Owner:GLOBAL LIFE SCI SOLUTIONS OPERATIONS UK LTD
Microorganism Producing Inosine and Method of Producing Inosine Using the Same
ActiveUS20100081173A1High yieldHigh expressionBacteriaSugar derivativesHigh concentrationInosinic acid
The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using the same. More particularly, the present invention relates to a recombinant microorganism of Corynebacterium genus producing inosine at high concentration by inactivating the gene encoding nucleoside hydrolase II and by enhancing the expression of the gene encoding 5′-nucleotidase, which still retains the characteristics of Corynebacterium ammoniagenes CJIP2401 (KCCM-10610).
Owner:CJ CHEILJEDANG CORP
Technique of chemical synthesis of producing adenosine
InactiveCN1727356ASimple production processSolve the real problemSugar derivativesChemical synthesisAcetic anhydride
A process for preparing adenosine from inosine by chemical synthesis method includes such steps as acetylating by excessive acetic anhydride under existence of anhydrous sodium acetate to obtain acetylinosine, chlorinating it by trichloroxyphosphate in pyridine to obtain chloro-acetylinosine, ammonolyzing in ammonia-methanol solution to obtain coarse adenosine, and refining. Its advantage is high output rate.
Owner:JINAN MINGXIN PHARMA
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