609 results about "Succinic acid" patented technology

The application relates to an engineering bacterium for high yield of observation blue and a construction method and application thereof, and belongs to the technical field of biological synthesis of natural dyes. The engineering bacterium for high yield of observation blue expresses icd, bpsA, glnA Y405F and gdhA; the engineering bacterium knocks out acnR, yggB, glsK, aceA and ldh. By knocking out the yggB and aceA genes, performing site-directed mutation (Y405F) on the glnA gene, replacing the glsK gene with the glnA Y405F gene, replacing the acnR gene with the icd gene, replacing the ldh gene with the gdhA gene, and integrating the bpsA gene, the application can block the formation of by-products such as lactate and succinic acid in the observation blue synthesis process, improve the flow direction of the citric acid->isocitric acid->alpha-ketoglutaric acid->glutamic acid->glutamine path, and then improve the intracellular glutamine concentration, so that the yield of observation blue is improved.

The invention discloses a preparation method of liposome for encapsulating euphausia superba oil, and belongs to the field of euphausia superba oil. Through material selection and hierarchical structure design, starch octenyl succinate, sodium alginate and pea protein are screened as composite wall materials, and the materials can achieve a synergistic effect on the molecule-interface-micro-nano scale to delay lipid oxidation, control the targeted release characteristic of active ingredients and improve the absorption efficiency of fat-soluble ingredients. Moreover, the liposome raw material of the euphausia superba oil is screened, and the liposome with low particle size and high stability is prepared.

The invention provides a polyethylene glycol derivative-collagen cartilage repair gel which is characterized by being prepared from the following components in parts by weight: 8 to 12 parts of collagen (namely COL) solution, 0.5 to 2 parts of polydeoxyribonucleotide (namely PDRN), 4 to 8 parts of polyethylene glycol disuccinimide succinate (namely SS-PEG-SS) solution and 0.1 to 0.4 part of tannic acid (namely TA), and particularly discloses a preparation method and application of the polyethylene glycol derivative-collagen cartilage repair gel. In a word, the composite gel and the collagen are subjected to efficient amidation reaction through SS-PEG-SS to form a stable three-dimensional network, so that the structural support of the type I collagen, the tissue repair of PDRN and the anti-inflammatory and anti-oxidation characteristics of tannic acid are successfully integrated; therefore, the composite material has the comprehensive performance of good structural stability, high mechanical strength, good biocompatibility, controllable degradation period, excellent needle passing performance and the like, and shows the wide application prospects of clear repair effect, remarkable component synergistic effect, mature production process, outstanding cost effectiveness and the like.

The invention provides an epoxidized soybean oil-binary acid bio-based dynamic polymer, a preparation method thereof and a paper-based strain sensor packaged by the epoxidized soybean oil-binary acid bio-based dynamic polymer. The preparation method of the dynamic polymer comprises the following steps: (1) taking epoxidized soybean oil as an epoxy monomer, aliphatic dibasic acid as a flexible monomer and aromatic dibasic acid as a rigid monomer, and carrying out polymerization reaction in the presence of a transesterification catalyst to obtain a dynamic polymer prepolymer; the aliphatic binary acid comprises succinic acid, adipic acid and sebacic acid; (2) removing bubbles from the dynamic polymer prepolymer; and (3) carrying out thermal curing on the dynamic polymer prepolymer to obtain the epoxidized soybean oil-binary acid bio-based dynamic polymer. The epoxidized soybean oil-binary acid bio-based dynamic polymer has good mechanical properties and hydrophobicity, a paper-based strain sensor based on the epoxidized soybean oil-binary acid bio-based dynamic polymer also has good mechanical properties and hydrophobicity, and the sensor has certain application potential in the field of human motion monitoring.

The invention belongs to the technical field of gel. The invention provides high-strength starch sodium octenylsuccinate gel and a preparation method thereof.The preparation method comprises the steps that S1, corn and cassava starch are mixed according to the mass ratio of 1: (4.4-4.6) to obtain a mixture, and then the mixture and soft water are dispersed according to the mass ratio of 1: 1.1 to obtain starch milk; s2, adjusting the pH value of the starch milk to 9.0 by using a sodium hydroxide solution, then adding octenyl succinic anhydride at 25 DEG C, then adding sucrose ester and pectin, neutralizing the pH value to 4.5 by using an HC1 solution, and carrying out suction filtration, washing and crushing to obtain starch sodium octenyl succinate powder; and S3, gelatinizing the starch sodium octenylsuccinate powder, and storing the gelatinized starch sodium octenylsuccinate powder at low temperature to obtain the high-strength starch sodium octenylsuccinate gel. According to the invention, by reducing the ratio of corn starch to cassava starch, the viscosity of the prepared starch sodium octenylsuccinate is further improved while a lower gelatinization temperature is ensured.

The invention relates to the technical field of pharmaceutical preparations, in particular to a solid dispersion-based sustained-release drug composite carrier as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out synergistic spray drying on double polymers (hydroxypropyl methylcellulose acetate succinate and polyvinylpyrrolidone-vinyl acetate copolymer) to form a solid dispersion; compounding with mesoporous silica and calcium silicate for localization, and spraying ethanol to activate pores; calcium stearate and magnesium stearate are sequentially added for lubrication; prefabricating a sustained-release skeleton master batch; and finally, mixing, rolling and forming. According to the method, through hierarchical structural design, the drug stability, the powder fluidity and the release controllability are remarkably improved, the method is suitable for industrial production of the dihydroergoline mesylate sustained release preparation, and a release curve is smooth and reliable.

The invention relates to the field of pharmaceutical preparations, and particularly discloses an amorphous-state tigorazan tablet and a preparation method thereof. The amorphous-state tigorazan tablet comprises a tablet and a coating material in a weight ratio of 100: (2-4), the tablet comprises the following raw materials: amorphous-state tigorazan, a carrier inclusion material, an excipient, a disintegrating agent, a lubricant and a flow aid, the dosage of the amorphous-state tigorazan is 20-30% of the total mass of all the raw materials of the tablet, and the dosage of the carrier inclusion material is 20-30% of the total mass of all the raw materials of the tablet. The weight ratio of the amorphous tigoran to the carrier inclusion material is 1: (0.80-1.15), and the carrier inclusion material is vitamin E polyethylene glycol succinate. The amorphous tigorazan tablet provided by the invention not only has higher solubility and dissolution rate, but also has higher stability and better hardness and friability, not only improves the bioavailability of drugs, but also avoids the use of organic solvents, simplifies the production process, reduces the risks of production safety and environmental protection, and is suitable for large-scale industrial production.

The invention discloses microcapsule powder for covering the oil smell of euphausia superba oil and a preparation method of the microcapsule powder, and belongs to the field of euphausia superba oil processing. The microcapsule powder is composed of 50-75% of OSA starch, 10-30% of euphausia superba oil, 3-20% of sodium alginate, 1-10% of succinic acid and 0.5-5% of calcium hydrophosphate, during preparation, the OSA starch is gelatinized and then sheared and homogenized with the euphausia superba oil to obtain a miniemulsion, the succinic acid, the sodium alginate and the calcium hydrophosphate are prepared into a mixed solution, the mixed solution is mixed with the miniemulsion in proportion, and spray drying is performed to obtain a finished product. An OSA starch-sodium alginate double-wall material system is adopted, a compact cross-linked layer is formed through pH response, peculiar smell substances such as trimethylamine can be completely masked, the astaxanthin retention rate is up to 95.14%, the embedding rate reaches 89.48%, krill oil oxidation is effectively inhibited, krill oil is converted into powder, the stability and the sensory property are improved, application of krill oil in the food field is widened, the technology is simple, and the method is suitable for industrial production. The method is suitable for industrial production.

The invention provides a method for separating and extracting bio-based succinic acid from fermentation liquor, which comprises the following steps: (1) enabling the fermentation liquor to sequentially pass through a ceramic membrane and a nanofiltration membrane, and decoloring to obtain bio-based succinic acid decolored liquor; (2) sequentially carrying out ion exchange impurity removal and concentration treatment on the bio-based succinic acid decoloring solution to obtain a bio-based succinic acid concentrated solution; and (3) carrying out multi-stage cooling crystallization on the bio-based succinic acid concentrated solution to obtain the bio-based succinic acid, the multi-stage cooling crystallization comprises first-stage crystallization, second-stage crystallization and third-stage crystallization which are carried out in sequence. Through the steps of integrated membrane filtration, decoloration, ion exchange, concentration, multi-stage crystallization and the like, thalli, proteins, pigments, inorganic ions and other impurities in fermentation liquor can be efficiently removed, so that a high-purity bio-based succinic acid product is obtained, meanwhile, the product yield is increased, and energy consumption and waste discharge are reduced.

The invention provides a multilayer lutein ester liposome as well as a preparation method and application thereof, and belongs to the field of food processing. The multi-layer lutein ester liposome is prepared from the following raw materials: 30 to 50 parts of lutein ester, 40 to 60 parts of soybean phosphatidylcholine, 5 to 20 parts of cholesterol, 10 to 25 parts of starch sodium octenylsuccinate, 20 to 40 parts of trehalose, 15 to 30 parts of mannitol, 4 to 10 parts of phosphatidyl glycerol, 1 to 2 parts of vitamin E acetate and 1 to 2 parts of ascorbyl palmitate. According to the present invention, through the specific food-grade raw material composition and the accurate ratio relationship, the comprehensive delivery system is constructed for the highly hydrophobic and unstable lutein ester, and the system synchronously achieves the high encapsulation efficiency, the excellent stability, the good water dispersibility and the slow release function.

The invention provides bio-based succinic acid and a preparation method and application thereof, the median particle size of the bio-based succinic acid is 300-500 [mu] m, and the bio-based succinic acid comprises the following particles in percentage by mass: 0-10% of particles with the particle size of d1, 30-40% of particles with the particle size of d2, 40-50% of particles with the particle size of d3 and 8-18% of particles with the particle size of d4, d1 is less than 150 [mu] m, 150 [mu] m < = d2 < 300 [mu] m, 300 [mu] m < = d3 < 500 [mu] m, and d4 > = 500 [mu] m. The bio-based succinic acid is large in particle size, controllable in particle size distribution and good in uniformity, not only solves the problem of dust raising in succinic acid application, but also can reduce the adhesive force among particles and avoid the problems of agglomeration and caking, so that the storage time of the bio-based succinic acid is prolonged, the succinic acid has proper friction force, and the service life of the bio-based succinic acid is prolonged. The storage performance and the downstream application performance are improved, and the application requirements of various scenes are met.

The invention relates to the technical field of biomedicine nanotechnology, in particular to a high-stability engineered exosome based on rigid hydrophobic anchoring and micelle disassembly and purification as well as a preparation method and application of the high-stability engineered exosome. According to the invention, a ternary surface structure of rigid hydrophobic anchoring-hydrophilic polymer spacer arm-targeting ligand (L-S-T) is constructed, cholesterol hemisuccinate or multi-branched lipid is selected as an anchoring group, and the problem that conventional phospholipid modification is easy to fall off in vivo and in an albumin-containing preparation is obviously solved; a technology of'micellar insertion after temperature control 'combined with'CMC critical concentration adjustment and purification' is adopted, lossless insertion of functional molecules is realized by utilizing thermodynamic driving force, and residual micelles are induced to be disintegrated into monomers by adjusting the concentration of a system to be lower than the concentration of critical micelles, so that efficient removal of free impurities is realized through conventional ultrafiltration. The engineered exosome has the advantages of long circulation, high targeting and excellent storage stability, and has important clinical application and commercial transformation prospects.

The present disclosure relates to a genetically modified microorganism satisfying some of predetermined conditions. The predetermined conditions include: (I) succinate dehydrogenase activity or fumarate reductase activity being reduced or inactivated relative to a wild-type microorganism; (II) lactate dehydrogenase activity being reduced or inactivated relative to the wild-type microorganism; (III) the genetically modified microorganism having modified phosphoenolpyruvate carboxylase activity showing resistance to feedback inhibition by aspartic acid in wild-type phosphoenolpyruvate carboxylase activity, or exogenous phosphoenolpyruvate carboxylase activity having higher resistance to feedback inhibition by aspartic acid than that of the wild-type phosphoenolpyruvate carboxylase activity shown by the wild-type microorganism; and (IV) pyruvate:quinone oxidoreductase being reduced or inactivated relative to the wild-type microorganism.

The present invention provides a solid dispersion of compound 1 or a pharmaceutical salt thereof, comprising the compound 1 or the pharmaceutical salt thereof as an active ingredient and a carrier material, wherein the carrier material is selected from one, two, or more of polyvinylpyrrolidone (PVP), copovidone, polyvinylpyrrolidone-vinyl acetate copolymer, hydroxypropyl methylcellulose acetate succinate, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, hydroxypropyl methylcellulose, polyethylene glycol, and ethyl cellulose, enabling the drug to have good stability, dissolution, and therapeutic effects. The formulation of the present invention provides rapid drug release and can reduce the oral burden of large-dose tablets on menopausal patients, thereby improving treatment compliance and treatment efficiency.

The invention discloses application of hydrogen-rich water in preparation of a drug for treating Duchenne type muscular dystrophy, and particularly relates to the technical field of medicines.The random control experiment is adopted, homologous c57 mice serve as a normal control group, mdx mice are randomly divided into a model group and a hydrogen-rich water group, and the exercise ability is evaluated through a four-limb holding power test and a rotating bar test; detecting mouse creatine kinase by an enzyme-linked immunosorbent assay; carrying out hematoxylin-eosin, NADH-tetrazole reductase and improved Goori three-color dyeing, and carrying out cytochrome C oxidase, succinate dehydrogenase and SDH-COX combined dyeing to observe the pathological change of the skeletal muscle tissue; the invention discloses that the muscle injury condition of a Duchenne type muscular dystrophy model mouse is improved by the hydrogen-rich water through a mitochondrial protection mechanism, and the hydrogen-rich water has a relatively high application prospect and a relatively high economic value.

The invention relates to a photocatalyst-based antibacterial modified cotton fiber and a preparation method thereof.The preparation method of the photocatalyst-based antibacterial modified cotton fiber comprises the following steps that S1, bismuth vanadate powder and sodium dodecyl benzene sulfonate are added into water and stirred, and a mixed solution is obtained; s2, adding starch octenyl succinate into water, and gelatinizing under a stirring condition to obtain gelatinized liquid; s3, mixing the gelatinized liquid and the mixed liquid, homogenizing, and spray-drying to obtain microcapsules; s4, adding microcapsules into ethanol, and adding azobisisoheptonitrile under a stirring condition, so as to obtain a modified solution; s5, cotton fibers are put into water in advance to be swelled and then put into the modification liquid, a reaction is carried out under the protective gas atmosphere, washing and drying are carried out, and the antibacterial modified cotton fibers based on the photocatalyst are prepared. The bismuth vanadate powder with photocatalytic activity is introduced into the cotton fiber in a chemical bonding manner, so that the cotton fiber is endowed with a lasting photodynamic antibacterial effect.

The application provides a Y molecular sieve adsorbent and a preparation method and application thereof. The preparation method comprises the following steps: mixing a pore-expanding agent and a Y molecular sieve, and calcining to obtain the Y molecular sieve adsorbent; wherein the pore-expanding agent comprises any one or a combination of at least two of sulfuric acid, hydrochloric acid, nitric acid, acetic acid, a sodium hydroxide solution, a potassium hydroxide solution, lactic acid, ammonia water, malic acid, succinic acid, propionic acid, formic acid, sodium carbonate, amino acid, ascorbic acid or sodium silicate. The application mixes the pore-expanding agent and the Y molecular sieve, and then performs calcination, so that the pore-expanding agent is effectively eliminated, the pore of the Y molecular sieve adsorbent is improved, the Y molecular sieve adsorbent with excellent adsorption performance is prepared, and efficient adsorption of carbon dioxide is realized. The preparation process of the Y molecular sieve adsorbent is simple, the preparation process cost is low, and the Y molecular sieve adsorbent has the advantages of green environmental protection.

The antioxidant activity of alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) and of alpha-tocopherol succinate (TS) has been examined in isolated hepatocytes and microsomal fractions from rat liver. Both TPGS and TS require esterase activity to yield free alpha-tocopherol and, hence, antioxidant activity. TPGS and TS consistently exerted a more effective antioxidant protection than an equivalent amount of directly-added free alpha-tocopherol. The low antioxidant efficiency of directly added free alpha-tocopherol in such water-based experimental systems as used here seems to be due to its extreme hydrophobicity. TPGS, on the other hand, is an extremely hydrophilic compound which is being examined as a useful source of alpha-tocopherol in certain clinical situations and is here shown to be a convenient and effective source for experimental studies into lipid peroxidation and antioxidant mechanisms.

The present application relates to the technical fields of medical health food, and discloses a preparation device for naringin compound loaded by octenyl succinic acid modified porous starch ester, which comprises a preparation liquid ultrasonic mixing cylinder assembly, a mixing top cover assembly is arranged on the top of the preparation liquid ultrasonic mixing cylinder assembly, and a mixed liquid shaking and stirring assembly is arranged on the mixing top cover assembly; a rocker arm base assembly is rotatably arranged at the bottom of the preparation liquid ultrasonic mixing cylinder assembly; a preparation liquid mixing cylinder assembly is fixedly arranged on both sides of the top of the preparation liquid ultrasonic mixing cylinder assembly; the preparation liquid ultrasonic mixing cylinder assembly comprises a preparation liquid ultrasonic mixing cylinder, a plurality of mixing cylinder bottom arm tables are fixedly arranged on the preparation liquid ultrasonic mixing cylinder through reinforcing rib plates, and a bottom arm table main shaft rod is fixedly arranged on the mixing cylinder bottom arm table; an aeration pipe is fixedly arranged at the bottom of the preparation liquid ultrasonic mixing cylinder, and a liquid pump is fixedly arranged outside the bottom of the preparation liquid ultrasonic mixing cylinder. The present application has the characteristics of sufficient mixing.

The invention discloses a (-)-menthol group-containing nicotinamide derivative with antifungal activity as well as a preparation method and application thereof, and relates to the technical field of synthesis of agricultural chemicals. The derivative has a structure as shown in a general formula (I), in the formula, n is an integer from 1 to 5, and R1, R2, R3 and R4 are specific substituent groups. Through a molecular hybridization strategy, the (-)-menthol, the N-fatty acyl piperazine bridge and the nicotinamide fragment are covalently linked, and a compound with a brand new structure is created. A biological activity test shows that the series of compounds have remarkable inhibitory activity on various plant pathogenic fungi, especially sclerotinia sclerotiorum and valsa mali of apple trees, and are low in cytotoxicity. Molecular docking research proves that the action target of the gene is succinate dehydrogenase (SDH). The invention provides a valuable leading structure for developing novel SDHI bactericides.

The invention discloses a decontamination and dust fall reagent as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) preparing a compound solution: adding ferrous gluconate, sodium alkyl sulfosuccinate, sodium alcohol ether sulfate, lauryl sodium sulfate and polyacrylamide into deionized water according to the mass fraction of 0.10%-0.15%, 0.05%-0.20%, 0.05%-0.15%, 0.10%-0.15% and 0.005%-0.02% respectively to obtain the compound solution; (2) preparing micro-nano bubble water; and (3) adding the compound solution into the micro-nano bubble water in a volume ratio of 1: (0.5-2), and fully mixing the compound solution and the micro-nano bubble water to obtain the decontamination and dust fall reagent. According to the decontaminating and dust-settling reagent prepared by the invention, an environment-friendly surfactant is selected, so that dust can be settled, toxic and harmful gases generated by explosion can be removed by utilizing the characteristic that micro-nano bubble water directly participates in catalytic oxidation, and a good decontaminating and dust-settling effect is achieved.

The application discloses a new ganbaxin-succinic acid co-crystal and a preparation method thereof. The method comprises the following steps: step 1, dissolving ganbaxin solid in solvent I; step 2, adding succinic acid solid into the solution obtained in step 1; step 3, heating the solution obtained in step 2 and keeping the temperature, and continuously stirring; step 4, filtering the clear solution obtained in step 3, and evaporating the filtrate; and step 5, drying the crystal obtained in step 5, and obtaining the ganbaxin-succinic acid co-crystal after drying. The solubility of the ganbaxin-succinic acid co-crystal obtained in water is 0.487 mg / mL, which is 10 times of that of the raw material medicine, and the water solubility of the ganbaxin-succinic acid co-crystal is much better than that of the original crystal.

The invention discloses a flexible glass cutting fluid and a preparation method thereof, and the preparation method comprises the following steps: S1, adding cellobiose into DMF, then adding chloroacetic anhydride and pyridine, and carrying out a stirring reaction to obtain an intermediate; s2, adding the intermediate into DMF (Dimethyl Formamide), and then carrying out constant-temperature reaction on glycerol monocaprylate, 2-(2-hydroxyphenyl) benzothiazole and triethylamine to obtain a modifier; s3, uniformly mixing a modifier, sodium dioctyl sulfosuccinate and a polyoxyethylene polyoxypropylene block copolymer, so as to obtain a composite surfactant; s4, adding the composite surfactant, the propylene glycol, the defoaming agent, the sterilizing agent and the triethanolamine into the water, and uniformly stirring to obtain the cleaning agent. According to the prepared cutting fluid, the protection effect on a flexible glass base material and a surface functional layer of the flexible glass base material is remarkably improved while the excellent wettability is kept, microcrack generation and surface damage in the cutting process are reduced, and the cutting fluid is particularly suitable for precise glass processing of flexible display devices.

This application relates to the field of materials, and provides a method for preparing all-starch foamed tableware. By weight, the all-starch foamed tableware comprises the following components: 85-92 parts of composite modified starch, 23-38 parts of plant cellulose, 1-2 parts of foaming agent, 3.5-7 parts of nucleating agent, 1-1.5 parts of plasticizer, and 3-6 parts of crosslinking agent; wherein the foaming agent includes at least one of sodium bicarbonate, ammonium bicarbonate, and ammonium carbonate; the nucleating agent includes at least one of talc, calcium carbonate, montmorillonite, diatomaceous earth, straw powder, chitosan, and cyclodextrin; the plasticizer includes at least one of glycerol, sorbitol, ethanol, and water; and the crosslinking agent includes at least one of citric acid, malic acid, tartaric acid, maleic acid, succinic acid, and adipic acid. This application not only comprehensively improves the water resistance, heat resistance, mechanical strength, and cell uniformity of the all-starch foamed tableware, but also ensures that the product meets usage requirements.

This invention discloses a mild and stable temperature-responsive microemulsion composition, its preparation method, and its applications, belonging to the fields of cosmetics and pharmaceutical technology. This invention uses a nonionic decyl glucoside and anionic sodium lauroyl glutamate, introducing tocopherol polyethylene glycol succinate and disodium EDTA, forming a dual stabilizing mechanism of "antioxidant + metal ion chelation," effectively protecting unstable active ingredients such as glycyrrhizin. Experiments show that in an accelerated test at 60℃, the retention rate of glycyrrhizin increased by more than 20%. The microemulsion composition prepared by this invention exhibits high stability, low irritation, and skin-targeted sustained-release properties.

The application relates to the field of genetic engineering, and discloses an Aspergillus niger, a construction method and application of the Aspergillus niger, and a method for producing citric acid and / or succinic acid. Aspergillus niger The Aspergillus niger is obtained by simultaneously overexpressing alpha-amylase and aspartic protease in a starting strain. The Aspergillus niger provided by the application can realize efficient degradation and conversion of starch by synergistically overexpressing amyA genes and pepA genes, solve the technical bottleneck that the original strain is limited in growth in a starch-based fermentation system and has insufficient acid production capacity, can efficiently produce succinic acid and citric acid by taking low-cost starch as the only carbon source, significantly reduce the industrial production cost of organic acid, and promote the green and sustainable upgrading of the fermentation industry.

The invention relates to the field of chemical treatment of printed circuit boards, and discloses a nitrogen-free environment-friendly neutralizer which is prepared from the following components by mass concentration: 20-30 g / L of sulfuric acid; 5-10 g / L of an activator; 5-10 g / L of a penetrant; 5-8 g / L of a stabilizer; 1-3 g / L of a surfactant; 0.5-2 g / L of a corrosion inhibitor; and the balance of water. The penetrant is composed of dioctyl sodium sulfosuccinate and hydrolytic polymaleic anhydride, and the stabilizer is composed of an acrylic acid-acrylate-sulfonate terpolymer and propylene glycol alginate. The nitrogen-free environment-friendly neutralizing agent prepared by the invention is applied to chemical treatment of the printed circuit board, can effectively remove substances such as residual biological manganese dioxide on the surface of the circuit board, can uniformly clean and corrode the board surface and the interior of holes of the circuit board, endows the circuit board with a good attachment surface, is beneficial to proceeding of a later copper deposition process, and improves the production efficiency. And the copper deposition uniformity is improved.