1630 results about "Succinic acid" patented technology

The invention relates to an engineering bacterium of high-yield ornamental blue as well as a construction method and application of the engineering bacterium, and belongs to the technical field of natural dye synthesis by a biological method. The engineering bacterium capable of highly producing the ornamental blue, disclosed by the invention, expresses icd, bpsA, glnAY405F and gd hA; acnR, yggB, glsK, aceA and ldh are knocked out from the engineering bacteria. According to the application, yggB and aceA genes are knocked out, site-directed mutagenesis (Y405F) is carried out on a glnA gene, a glsK gene is replaced by a glnAY405F gene, an acnR gene is replaced by an icd gene, an ldh gene is replaced by a gdhA gene, and a bpsA gene is integrated, so that the formation of by-products such as lactate and succinic acid in a blue-viewing synthesis process can be blocked; the flow direction of a passage from citric acid to isocitric acid to alpha-ketoglutaric acid to glutamic acid to glutamine is improved, so that the concentration of glutamine in cells is improved, and the yield of the ornamental blue is improved.

Embodiments of the present invention provide methods and intermediates for the large scale preparation of 2, 4, 6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl] benzamide hemisuccinate, as well as formulations and product forms prepared by these methods. Embodiments of the present invention further provide for the preparation of lamidetan acetate (2, 4, 6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl] benzamide acetate) and / or a pharmaceutical composition thereof, and / or the use of lamidetan acetate and formulations thereof in subcutaneous drug delivery.

The preparation method comprises the following steps: firstly, uniformly stirring and mixing synthetic fluorophlogopite, silica, polymethylsilsesquioxane, boron nitride, bismuth oxychloride, zinc stearate, aluminum starch octenylsuccinate, mica, aluminum oxide, hydrolyzed sodium hyaluronate and toner in a stirring homogenizer; then uniformly mixing polydimethylsiloxane, octyldodecanol stearoyloxy stearate, isoamyl laurate, diisostearyl malate, phenoxyethanol and caprylyl glycol, and heating to 45 + / -5 DEG C; pouring the mixture into an oil spraying barrel of a stirring homogenizer, uniformly stirring and mixing while spraying oil, crushing, then carrying out airflow crushing, sieving the material, putting the sieved material into a mold plate, and carrying out compression molding, so as to obtain a pressed powder block; and putting the mixture into a packing material powder box to obtain the make-up fixing and brightening pressed powder. The pressed powder is prepared by adding an airflow crushing process, the particle size of the powder is smaller, the powder is dispersed more uniformly, the powder is pressed into the solid pressed powder, and the phenomenon of powder flying is well reduced while makeup fixing and brightening effects are achieved.

The invention relates to a starch-based soft capsule shell and a preparation method thereof. The starch-based soft capsule shell is prepared from the following raw materials in parts by mass: 60 to 70 parts of hydroxypropyl starch, 9 to 20 parts of carrageenan, 5 to 15 parts of diquat, 5 to 15 parts of polylysine, 5 to 10 parts of hydroxypropyl methyl cellulose acetate succinate, 15 to 20 parts of glycerol and 30 to 40 parts of pure water. According to the soft capsule shell, hydroxypropyl starch serves as a base material, gelatin is not added, the conditions of poor weather resistance and fishy smell caused by use of gelatin are avoided, through the synergistic effect of all the components, the defects that a starch-based material is poor in plasticity, fragile and insufficient in mechanical strength are overcome, the structural stability is enhanced through chemical crosslinking, and the mechanical strength is improved; and the mechanical property is improved by virtue of physical compounding, so that the low-temperature resistance, high-temperature resistance and mechanical strength of the capsule skin are improved.

This application discloses a detergent tablet free of SLS surfactant and its preparation method. The detergent tablet includes a film-forming agent, an anionic surfactant, a non-ionic surfactant, a chelating agent, an enzyme preparation, an auxiliary agent and a essence. The film-forming agent includes one or more of polyvinyl alcohol, cellulose, and dodecenyl succinate starch ester. The anionic surfactant includes at least two of sodium α-olefin sulfonate, sodium fatty acid methyl ester sulfonate, and sodium hydroxyethyl sulfonate. The non-ionic surfactant includes at least two of fatty alcohol polyoxyethylene ethers, fatty acid methyl ester ethoxylate, and oil ethoxylate.

The invention provides a recombinant pichia kudriavzevii strain and application thereof, pichia kudriavzevii is taken as an original strain, and a reduced TCA pathway is introduced and comprises the following steps: overexpressing fumarate reductase FRD in the strain; weakening or inactivating an ethanol pathway, comprising: knocking out any one or a combination of at least two of encoding genes of ethanol dehydrogenase ADH1, ADH3 or ADH6; enhancing the PPP pathway in the pentose phosphate pathway of the strain, including: overexpressing glucose-6-phosphate dehydrogenase ZWF1 and / or 6-phosphogluconate dehydrogenase GND1; the method for reducing the activity of the malate dehydrogenase MDH2 in the TCA circulation pathway comprises the step of knocking out the coding gene of the malate dehydrogenase MDH2 in the TCA pathway. The pichia kudriavzevii is modified by using genetic engineering and metabolic engineering methods, so that the yield and the yield of succinic acid are increased, and the pichia kudriavzevii has important application prospects in industrial production.

The invention belongs to the technical field of preparation of blocking removers, and particularly relates to a composite chelating blocking remover for an oil field and a preparation method of the composite chelating blocking remover. The composite chelating blocking remover for the oil field is prepared from the following raw materials in percentage by mass: 7 to 9 percent of 1-butyl-3-methylimidazole dodecyl sulfonate, 5 to 7 percent of erucamide propyl hydroxypropyl sulfobetaine, 3 to 4 percent of di-(2-ethylhexyl) sodium sulfosuccinate, 4 to 5 percent of ethylenediamine di-o-hydroxyphenylacetic acid, 5 to 7 percent of N, N '-di (2-hydroxybenzyl) ethylenediamine-N, N'-bis (2-hydroxybenzyl)-N, N '-bis (2-ethylhexyl)-N, N'-bis (2-hydroxybenzyl)-N, N '-bis (2-hydroxybenzyl)-N, N'-bis (2-hydroxyphenyl)-N, N '-bis (2-hydroxyphenyl)-N, N'-bis (2-hydroxyphenyl)-N The cleaning agent is prepared from the following components in percentage by weight: 3 to 4 percent of N, N '-diacetic acid, 2 to 3 percent of O-(3-(benzyloxy) propyl) hydroxylamine, 1 to 2 percent of heptadecenyl hydroxyethyl imidazoline quaternary ammonium salt, 1 to 1.5 percent of dimethyl diallyl ammonium chloride homopolymer and the balance of water. The composite chelating blocking remover for the oil field has excellent scale dissolution rate and paraffin inhibition rate when being applied to complex scale blocking removal of the oil field.

The invention discloses an enzyme response type KRAS targeted protein degradation chimera as well as a preparation method and application thereof, and belongs to the technical field of tumor targeted therapy. The enzyme response type KRAS targeted protein degradation chimera disclosed by the invention is obtained by covalently linking three parts, namely a KRAS targeted protein degradation chimera, an enzyme response type amino acid sequence and a cell penetrating peptide amino acid sequence, wherein the KRAS targeted protein degradation chimera is obtained by linking a KRAS targeted peptide and a VHL E3 ligase ligand through succinic acid. The enzyme response type KRAS targeted protein degradation chimera releases the KRAS targeted protein degradation chimera under the action of ATG4 enzyme shearing, and shows a relatively strong lung cancer resisting effect in vitro and in vivo. The invention has significant advantages in the aspect of antitumor drugs, and opens up a new field for the development of targeted protein degradation chimera drugs. Enzyme response type KRAS targeted protein degradation chimera molecular structural formula as follows: # imgabs0 #

The invention relates to the technical field of welding materials, and discloses washable semiconductor solder paste and a preparation method and application thereof. The washable semiconductor solder paste comprises scaling powder and tin powder, wherein the mass ratio of the scaling powder to the tin powder is 1: (8-9.6); the soldering flux comprises the following raw material components: a film-forming agent, composite organic acid, a thixotropic agent, a surfactant, an antioxidant and a solvent, wherein the composite organic acid is composed of succinic acid and glutaric acid according to the mass ratio of (1-3): (1-2.5). According to the washable semiconductor solder paste, the particle size, the melting point and the alloy components of the tin powder are controlled, composite organic acid composed of succinic acid and glutaric acid in a specific proportion is adopted in the soldering flux, and other components are matched with one another; the tin powder and the soldering flux in a specific mass ratio are combined, so that the prepared washable semiconductor solder paste is good in wettability, the expansion rate is larger than or equal to 85%, the storage life reaches 3 months, and the washable semiconductor solder paste can be directly cleaned with water after being welded and is high in corrosion resistance and oxidation resistance.

The invention belongs to the technical field of contact lenses, and provides a moisturizing contact lens containing a hyaluronic acid coating and a preparation method of the moisturizing contact lens. The preparation method comprises the following steps: carrying out ultrasonic mixing on a hydrophilic monomer, a siloxane monomer, a cross-linking agent and an initiator, injecting the mixed solution into a contact lens mold, and carrying out polymerization reaction to obtain a contact lens material; mixing the chitosan solution, the shellac acid solution, the hyaluronic acid solution and the vitamin E succinate solution to obtain a hyaluronic acid mixed solution; and soaking the contact lens material in the hyaluronic acid mixed solution, adding a cross-linking agent, curing, and drying to obtain the moisturizing contact lens containing the hyaluronic acid coating. The contact lens disclosed by the invention has excellent moisture retention, good light transmission performance, swelling performance and excellent mechanical property, the wearing comfort is remarkably improved, and the contact lens is suitable for being worn for a long time; the preparation method disclosed by the invention is environment-friendly and easy to industrialize.

The invention relates to a method for treating a waste iron phosphate positive electrode material by a phosphoric acid-hydrogen peroxide method matched with a specific complexing agent. The method comprises the following steps: crushing the positive electrode material of the waste lithium iron phosphate battery, adding the crushed positive electrode material into deionized water, and stirring to prepare slurry; heating the slurry, dropwise adding a phosphoric acid-hydrogen peroxide mixed solution and a complexing agent, adding a NaOH solution to adjust the pH value to 3.5, and filtering to obtain a filtrate and a filter cake; adding a NaOH solution into the filtrate, and adjusting the pH value to 10 to obtain lithium phosphate; performing evaporative crystallization on the filter cake to obtain trisodium phosphate; the complexing agent is prepared by adding pentasodium salt of amino trimethylene phosphonic acid, triallyl citrate, epoxysuccinic acid and DMF (Dimethyl Formamide) into a reaction kettle, mixing, adding ammonia water to adjust the pH value to be 10, and distilling to remove the DMF after the reaction is finished. The precipitation rate of Fe reaches up to 99.99%, the leaching rate of Li reaches up to 99.91%, and efficient separation and recycling of lithium and iron are achieved.

The application relates to an engineering bacterium for high yield of observation blue and a construction method and application thereof, and belongs to the technical field of biological synthesis of natural dyes. The engineering bacterium for high yield of observation blue expresses icd, bpsA, glnA Y405F and gdhA; the engineering bacterium knocks out acnR, yggB, glsK, aceA and ldh. By knocking out the yggB and aceA genes, performing site-directed mutation (Y405F) on the glnA gene, replacing the glsK gene with the glnA Y405F gene, replacing the acnR gene with the icd gene, replacing the ldh gene with the gdhA gene, and integrating the bpsA gene, the application can block the formation of by-products such as lactate and succinic acid in the observation blue synthesis process, improve the flow direction of the citric acid->isocitric acid->alpha-ketoglutaric acid->glutamic acid->glutamine path, and then improve the intracellular glutamine concentration, so that the yield of observation blue is improved.

The present application relates to a chelated iron desulfurizer, which is composed of a high-price soluble iron salt, a chelating agent, a pH buffer and water, wherein the chelating agent is a compound of sodium polyetheramine tetraacetate and at least one of N,N-diethylcarboxylic acid-based ethylenediamino-3-hydroxysuccinic acid, a polycarboxylic acid chelating agent or an amino acid-derived chelating agent; or the chelating agent is a compound of tetrasodium N,N-diethylcarboxylic acid-based ethylenediamino-3-hydroxysuccinic acid and at least one of sodium polyetheramine tetraacetate, a polycarboxylic acid chelating agent or an amino acid-derived chelating agent. Compared with the existing commonly used desulfurizers EDTA or NTA, the chelating ability of the present application's chelated iron desulfurizer is significantly improved, the iron ion regeneration ability is significantly enhanced, and the desulfurization effect is comparable to EDTA or NTA.

The invention belongs to the field of food preparation of non-alcoholic beverages, and particularly relates to a medicinal and edible solid beverage and a preparation method thereof. The medicinal and edible solid beverage comprises slow-release particles and functional drinks, the slow-release particles are prepared by performing enzymolysis on medicinal and edible substances by adopting immobilized bromelain and the like, performing microwave foam drying on an enzymolysis filtrate, and then encapsulating the filtrate with beta-cyclodextrin modified by starch sodium octenylsuccinate, the slow-release particles are brewed with boiling water, and the functional drinks are prepared into the medicinal and edible solid beverage. And bioactive compounds can be completely released within 15 minutes. The functional drink is an unstable foaming substance and can be used as a drinking prompt substance, and consumers are reminded to enjoy the solid drink with the best flavor in time by observing the dissipation condition of foam. The medicinal and edible solid beverage disclosed by the invention solves the problem that the optimal flavor of the existing solid beverage cannot be accurately transmitted to consumers, has relatively high sensory evaluation in the aspects of appearance, color, flavor and mouth feel, and also has a relatively good antioxidant effect.

The invention belongs to the technical field of stem cell biological preparations, and particularly relates to an anti-aging compound preparation based on stem cells and application of the anti-aging compound preparation in delaying skin aging. The composition is composed of an inner water phase, a middle oil phase and an outer water phase, wherein the inner water phase is prepared from the following components: stem cell exosomes, hyaluronic acid, nicotinamide ribose, trehalose, mannitol, glycine and a citric acid buffer solution; the medium oil phase is prepared from the following components: medium chain triglyceride, shea butter, vitamin E succinate, PEG (Polyethylene Glycol) modified ceramide NP and cholesterol succinic acid monoester; the external water phase is prepared from the following components: polydatin, cellulose nanocrystals and an emulsifying agent. On the basis of a W / O / W emulsion system, a multi-layer anti-aging mechanism is constructed by utilizing a three-dimensional delivery framework of an inner water phase, an oil phase and an outer water phase and space-time synergy of active ingredients, the exosome permeation efficiency is improved through microneedle introduction, and the anti-oxidation and barrier repair effects are achieved by using multiple ingredients.

The invention relates to the technical field of biomedical dressings, in particular to a dressing for a diabetic foot wound surface and a preparation method of the dressing. 0.2 to 0.8 part of reduced graphene oxide; 2 to 5 parts of beta-1, 3-glucan modified by chondroitin sulfate; 0.08 to 0.3 part of silver nitrate; 3 to 7 parts of N-isopropyl acrylamide-co-acrylic acid; 0.15 to 0.4 part of N, N '-methylene bisacrylamide; 2 to 5 parts of sulfhydrylated hyaluronic acid; 0.3 to 0.8 part of D-alpha-vitamin E polyethylene glycol succinate; 2 to 5 parts of amino-functionalized mesoporous silica; 1 to 3 parts of L-arginine-L-glutamate; 0.1 to 0.4 part of genipin; the super-strong mechanical property and the super-strong flexibility are realized, so that the dressing can better adapt to the irregular shape of a wound surface, and continuous protection is provided.

The invention provides a green compound scale inhibitor for geothermal fluid. The compound scale inhibitor comprises modified polyaspartic acid, high-hydrolysis polymaleic anhydride, polyepoxysuccinic acid and polyacrylic acid. According to the environment-friendly compound scale inhibitor for the geothermal fluid, the modified polyaspartic acid, the high-hydrolysis polymaleic anhydride, the polyepoxysuccinic acid and the polyacrylic acid are compounded, a good synergistic effect is achieved, scale inhibition is achieved through chelation solubilization and lattice distortion, the scale inhibition advantage in actual geothermal water is obvious, and the environment-friendly compound scale inhibitor has a good actual popularization value.

The invention provides an additive composition for promoting itraconazole absorption, and the additive composition is prepared from the following components in parts by mass: 20 to 40 parts of modified hydroxypropyl methylcellulose acetic acid succinate, 10 to 25 parts of copovidone, 5 to 15 parts of N-capryloyl sodium salicylate, 2 to 8 parts of nano silicon dioxide and 3 to 10 parts of polyoxyethylene-polyoxypropylene segmented copolymer. According to the additive composition disclosed by the invention, the problems of dissolution rate, bioavailability and stability of the itraconazole oral preparation are comprehensively solved through polymer modification, compounding synergy and parameter optimization, and the process cost is remarkably lower than that of the prior art.

The invention relates to the field of bioengineering, in particular to a construction method and application of recombinant yarrowia lipolytica with high succinic acid yield. The recombinant yarrowia lipolytica disclosed by the invention simultaneously expresses a reduced tricarboxylic acid pathway related gene, a glyoxylic acid circulation pathway related group, a heterologous dicarboxylic acid transport related gene and a mitochondrial transport related gene, and an endogenous dicarboxylic acid transport protein coding gene is also knocked out; and a natural promoter of an isocitrate dehydrogenase coding gene IDH1 is replaced. The recombinant yarrowia lipolytica constructed by the invention can produce 112.85 g / L of succinic acid after fed-batch fermentation under the condition of not controlling pH, and efficient synthesis of succinic acid in the yarrowia lipolytica is realized.

The invention belongs to the technical field of daily chemistry, and provides a triple compound acid composition with skin brightening and acne removing effects, a product and application of the triple compound acid composition and the product, the triple compound acid composition comprises mandelic acid, salicylic acid and succinic acid, and the mass ratio of the mandelic acid to the salicylic acid to the succinic acid is (3-6): (1-2): (1-2). The invention further provides a product containing the composition and application of the product. The composition provided by the invention is synergistically used, has a synergistic effect in the aspect of exfoliating, especially in the aspect of improving the activity of kallikrein 5 (KLK5), not only has the effects of biological skin glowing and exfoliating, but also can efficiently down-regulate the expression of I-type 5alpha-reductase genes, so that the synthesis of sebum is inhibited, and an oil control effect is achieved; in addition, the composition provided by the invention has the effects of brightening, inhibiting bacteria and resisting inflammation, has low sensitization, can be used for removing acnes, takes effect quickly and does not relapse.

The invention discloses a hydrogel for gastric perforation repair, which belongs to the field of bioadhesives. The technical scheme is as follows: a hydrogel for gastric perforation repair is generated by chemical reaction of compound A and compound B; compound A is a polyethylene glycol derivative A with a terminal active group α; the terminal active group α is succinimidyl succinate; compound B is a polyethylene glycol derivative B with a terminal active group β; the terminal active group β is an amino group; when compound A reacts with compound B, the terminal active group α and the terminal active group β chemically react to form an amide bond. The beneficial effects of the invention are as follows: the hydrogel for gastric perforation repair provided by the invention has a fast gelation speed, can be gelled in situ, is easy to use, has strong adhesion to gastric tissue, has a low swelling rate in simulated gastric fluid and PBS solution, has a strong ability to resist simulated gastric fluid corrosion, has good compression resistance and anti-peristalsis performance, has good biocompatibility, and can be safely degraded.

The invention provides a catalyst for preparing 1, 4-butanediol through hydrogenation of succinate and a preparation method and application of the catalyst, the structural formula of the catalyst is aAbBcCdD / (xZ1 + yZ2), a component A is selected from at least one of Ru, Os, Rh, Ir, Pd or Pt, a component B is selected from at least one of Cr, Mn, Fe, Co, Ni or Cu, a component C is an oxide of at least one metal of Ga, In, Ge, Sn, Pb, Sb, Bi, Se, Te, Nb, Mo, W, Re, Al, Ti, Zr or Zn, a component D is an oxide of at least one metal of alkaline earth or rare earth, and a component E is an oxide of at least one metal of alkaline earth or rare earth. Z1 is a carrier with high specific surface area, and Z2 is a carrier with high thermal conductivity; the mass percentage content of each component is as follows: a is 0.1 to 10 weight percent, b is 0 to 60 weight percent, c is 0 to 50 weight percent, d is 0 to 20 weight percent, x is 10 to 90 weight percent, and y is 0 to 40 weight percent; or a is equal to 0, b is equal to 15-70 wt%, c is equal to 0-80 wt%, d is equal to 0-15 wt%, x is equal to 0-45 wt%, y is equal to 0-20 wt%, and c and d are not equal to 0 at the same time. The catalyst has excellent catalytic performance on preparation of 1, 4-butanediol by hydrogenation of mono, di or polyester of succinic acid esters including monohydric, dihydric or polyhydric alcohols.

The invention discloses a method for detecting drug resistance of botrytis cinerea to succinate dehydrogenase (SDHI) bactericides. On the basis of an RPA-CRISPR / Cas12a system, a specific primer pair amplification target fragment and crRNA for activating Cas12a trans-cleavage activity are designed aiming at key mutation sites related to drug resistance in a bactericide action target SdhB gene, so that fluorescent light visible to naked eyes can be generated only when a resistant strain sequence is matched with the crRNA, and the fluorescent light is opposite to the fluorescent light generated when a sensitive strain sequence is matched with the crRNA. The method provided by the invention overcomes the dependence on laboratories and large instruments in the traditional drug resistance detection method, provides key technical support for accurate prevention and control and drug resistance management of grape gray mold, and provides direct drug use basis for scientific prevention and control in the field.

The invention belongs to the field of metabolic engineering, and discloses a genetically engineered bacterium of high-yield beta-alanine as well as a construction method and application of the genetically engineered bacterium. The genetically engineered bacterium takes escherichia coli W3110 as an original strain, and is obtained by performing the following gene editing on a genome of the escherichia coli W3110, the genetically engineered bacterium does not express proteins such as lactose operon repressor protein, pyruvate dehydrogenase, acetokinase and the like; protein such as aspartic acid-alpha-decarboxylase, phosphoenolpyruvate carboxylase, pyruvate carboxylase and the like is overexpressed; the phosphoenolpyruvate carboxykinase is replaced by phosphoenolpyruvate carboxykinase from Mannheim succinic acid producing bacteria. The genetically engineered bacterium BA-17 for high yield of beta-alanine, which is constructed by the invention, is fermented in a 5L fermentation tank for 60 hours, the yield of beta-alanine reaches 126.7 g / L, the conversion rate reaches 60.3%, and the production intensity reaches 2.11 g / L / h.

The invention discloses a method for catalytic synthesis of malonic acid by using whole cells, and belongs to the field of bioengineering. According to the invention, escherichia coli BL21 (DE3) is taken as a host, an aspartic acid ammonia lyase gene aspA and an aspartic acid-alpha-decarboxylase gene panD, a succinate semialdehyde dehydrogenase gene yneI and a beta-alanine pyruvate transaminase gene, a beta-alanine pyruvate transaminase gene bauA and a malonyl-coenzyme A reductase gene mcr-C are expressed in modules, and recombinant escherichia coli is constructed. The malonic acid is produced by adopting a whole-cell catalysis method, so that the production period is shortened, the production efficiency of the malonic acid is improved, and the yield of the malonic acid can reach 51.0 g / L after the malonic acid is catalyzed for 24 hours.

The invention discloses a preparation method of a double embedding emulsion preparation / emulsion based on octenyl succinic acid cyclodextrin ester, and relates to an inclusion compound based on modified cyclodextrin and a stable Pickering emulsion system thereof. According to the method, the uniformity of the cyclodextrin modification substitution degree is improved through ultrasonic assistance, the embedding rate and the embedding stability of hydrophobic active ingredients can be improved, meanwhile, the Pickering emulsion is stabilized, preparation of the double-embedded emulsion preparation is achieved, and the stability and the packaging efficiency of an emulsion preparation packaging delivery system can be effectively improved through the method. The method comprises the following steps: 1, preparing octenyl succinic acid cyclodextrin ester; 2, preparing an OSA-beta-CD / phenolic compound clathrate compound; and 3, preparing the dual-embedding emulsion preparation / emulsion. The invention provides a preparation method of a double-embedding emulsion preparation / emulsion based on octenyl succinic acid cyclodextrin ester. The double-embedding emulsion preparation / emulsion can be applied to a double-embedding food functional component delivery system.

The invention discloses an oil-controlling and acne-removing synergistic composition which comprises the following components in percentage by weight: 0.8 to 2.0 percent of succinic acid, 0.3 to 1.0 percent of salicylic acid derivative and 0.5 to 1.5 percent of PCA (Principal Component Analysis) zinc. The invention also provides a sustained-release body. The sustained-release body is prepared from the following components in percentage by weight: 0.8 to 2.0 percent of succinic acid, 0.3 to 1.0 percent of salicylic acid derivative, 0.5 to 1.5 percent of PCA zinc, 1.0 to 2.5 percent of lactobionic acid, 1.0 to 3.0 percent of lactobacillus fermentation product, 2.0 to 4.0 percent of aminated modified diatomite and 0.1 to 0.3 percent of citric acid. The invention also provides a preparation method and application of the sustained release body. The acne-removing shampoo has low irritation, and can be used for controlling oil and removing acnes for a long time and efficiently dredging hair follicles.

The invention discloses a preparation method of liposome for encapsulating euphausia superba oil, and belongs to the field of euphausia superba oil. Through material selection and hierarchical structure design, starch octenyl succinate, sodium alginate and pea protein are screened as composite wall materials, and the materials can achieve a synergistic effect on the molecule-interface-micro-nano scale to delay lipid oxidation, control the targeted release characteristic of active ingredients and improve the absorption efficiency of fat-soluble ingredients. Moreover, the liposome raw material of the euphausia superba oil is screened, and the liposome with low particle size and high stability is prepared.

The invention provides a betaine succinate eutectic crystal as well as a preparation method and application thereof, and belongs to the technical field of eutectic crystal manufacturing. The structural formula of the succinic acid betaine eutectic crystal is shown as a formula I, the molecular formula of the succinic acid betaine eutectic crystal is C28H56N4O16, in the succinic acid betaine eutectic crystal, the molar ratio of succinic acid to betaine is 1: 2, and the succinic acid betaine eutectic crystal has low irritation and excellent effects.