3307 results about "Aqueous solubility" patented technology

The invention relates to a flexible aqueous binder for a lithium battery negative electrode and a preparation method thereof. The preparation method comprises the following steps: firstly, preparing a flexible polyurethane prepolymer containing vinyl by taking hydroxyl-terminated polybutadiene, isocyanate and hydroxyl acrylate as main raw materials; vinyl-containing compounds such as water-soluble acrylic acid (salt) or acrylamide, oil-soluble acrylic ester or acrylonitrile and the like are used as monomers and are combined with a flexible polyurethane prepolymer to prepare the negative water-based binder with flexible cross-linking points through free radical polymerization. The aqueous binder prepared by the technical method provided by the invention can realize point-to-point and point-to-line bonding modes with a pole piece active substance on a microstructure, so that the bonding strength of the active layer material and a copper foil is improved on the premise of not influencing the electrolyte resistance of the binder; and the flexibility of the negative pole piece and the subsequent processing stability are obviously improved.

The invention relates to a particulate composition comprising, or substantially consisting of, urea, an inhibitor, preferably a urease inhibitor and / or a nitrification inhibitor, and an additive, wherein the additive comprises components (i) and (ii): (i) a carboxylic acid or an anhydride, salt, or derivative thereof; preferably a carboxylic acid salt or a carboxylic acid derivative, more preferably a carboxylic acid salt; and (ii) a polar polymer; preferably a water-soluble polar polymer. The invention further relates to a process for preparing the particulate composition, an additive for a particulate composition, and the use of the particulate composition as a fertilizer.

The invention provides a photosensitive resin composition containing an anthracene methyl quaternary ammonium salt photosensitizer and application of the photosensitive resin composition, a structural main body anthracene ring of the photosensitizer is introduced into methylene substituted by a quaternary ammonium group at a position 10 and / or a position 9, and an acid radical or halogen is adopted as an equilibrium anion; compared with a commercially available anthracene photosensitizer, the photosensitizer has excellent fat solubility and good water solubility through introduction of the quaternary ammonium salt on the premise that the photobleaching property is retained, great potential is brought to formula design of the photosensitive composition, and development waste in a later development process can be greatly reduced; the method can be widely applied to the photo-curing fields of dry films, paints, coatings, printing ink, forming materials and the like.

The invention discloses a bionic lignin-based saline-alkali soil improvement material and a preparation method thereof, and belongs to the technical field of high polymer materials and soil improvement. According to the saline-alkali soil improving material, lignin or a derivative thereof serves as a framework, glutenin charge distribution and a dynamic disulfide bond sodium ion response function are simulated, and the sequence and the proportion of chain segments of sulfonic acid groups and quaternary ammonium salt groups are accurately regulated and controlled through step-by-step activation and alternate copolymerization in an aqueous solution polymerization reaction system; positive and negative charges form more uniform sequence distribution, so that the amphipathy of the lignin compound is realized; then, sulfydryl is introduced through click chemistry, linear regulation and control of material viscosity and water solubility are achieved through the chain transfer characteristic of multi-sulfydryl functional groups, and the requirements of different saline-alkali soil application scenes are met. The limitation that a traditional lignin product is single in function is broken through, efficient utilization of lignin is achieved, and the intelligent saline-alkali soil improvement material integrating high stability and pH and Na < + > multi-environment response is developed.

The invention discloses an impregnation liquid for preparing hydrogenated bisphenol A through bisphenol A hydrogenation. The impregnation liquid comprises a Ru complex, a water-soluble nonionic surfactant and water, wherein the molecular size of the Ru complex is greater than 1nm. According to the preparation method disclosed by the invention, by adopting the impregnation liquid containing the Ru complex of which the molecular size is greater than 1nm and the water-soluble nonionic surfactant, more Ru complex of which the molecular size is greater than 1nm can exist in mesoporous channels of an activated carbon carrier in an impregnation process, so that the contact probability of an active phase and a reactant bisphenol A molecule is increased; the purposes of improving the active metal utilization rate and improving the catalyst activity are achieved.

The invention relates to the technical field of temporary plugging agents, and discloses a water-soluble temporary plugging agent for oil well fracturing and a preparation method thereof. According to the prepared water-soluble temporary plugging agent, sodium lignin sulfonate / graphene oxide serves as a core, then the surface of the core layer is coated with a polyacrylic acid-polyacrylamide copolymer to form a first shell layer, and then the surface of the first shell layer is coated with acrylate modified chitosan to form a second shell layer; the temporary plugging agent is applied to oil well fracturing, not only has excellent plugging performance, dissolving performance and anti-shearing performance, but also can improve the transportation capacity of the temporary plugging agent in the oil well fracturing process.

The invention discloses a low-water-solubility medicine crystal as well as a preparation method and application thereof. The compound Z pamoate crystal form I has large characteristic diffraction peaks at one or more positions with diffraction angles 2 theta of 9.9 + / -0.2 degrees, 10.7 + / -0.2 degrees, 12.1 + / -0.2 degrees, 14.9 + / -0.2 degrees, 17.3 + / -0.2 degrees, 19.4 + / -0.2 degrees, 20.7 + / -0.2 degrees and 23.1 + / -0.2 degrees. Compared with an amorphous compound Z pamoate, the crystal provided by the invention has the advantages of good stability, no crystal transformation phenomenon, no obvious increase of related substances and low solubility; the production process is simple, only water is used as a solvent in the whole process, and no organic solvent is used; when the long-acting slow-release anti-Parkinson medicine composition is prepared from the compound Z pamoate crystal form I, the medicine encapsulation efficiency is high, the burst release is low, the composition continuously releases the medicine in vivo for more than 2 weeks, the administration frequency of a patient can be reduced, and the medication compliance is improved.

The invention discloses an oligopeptide from undaria pinnatifida and application thereof. The amino acid sequence of the oligopeptide is YRKD, and the molecular weight is 580.63 g / mol. The polypeptide is identified from undaria pinnatifida through a high performance liquid chromatography technology for the first time, and an unreported oligopeptide capable of inhibiting tyrosinase and cooperating with vitamin C to synergistically inhibit tyrosinase is screened out. The oligopeptide derived from undaria pinnatifida is synthesized by a solid phase method, has the characteristics of safety, no toxicity, good water solubility and good stability, and is combined with vitamin C to generate a synergistic effect and synergistically increase the inhibition effect on tyrosinase, so that the oligopeptide can achieve a better tyrosinase inhibition effect at a lower and more stable concentration; the use concentration of the oligopeptide can be greatly reduced, the stability is enhanced, and the oligopeptide can be widely applied to preparation of cosmetics, medicines, health-care products or food additives, and has important economic value and social significance.

The invention discloses an organic silicon composite solid defoaming agent for space station water treatment and a preparation method of the organic silicon composite solid defoaming agent, and relates to the technical field of defoaming agents. The organic silicon composite solid defoaming agent for space station water treatment comprises the following raw materials in parts by weight: 25-35 parts of polydimethylsiloxane, 5-10 parts of water-soluble silicone oil, 10-15 parts of white carbon black, 3-5 parts of an emulsifier, 3-4 parts of a dispersant and 25-35 parts of a carrier. The preparation method comprises the following steps: reacting 1H, 1H-perfluorohexylamine with epoxy chloropropane to generate an intermediate 1, reacting the intermediate 1 with lauryl amine to generate an intermediate 2, and reacting the intermediate 2 with amino-polyethylene glycol-carboxyl to obtain the emulsifier. The prepared organic silicon composite solid defoaming agent for space station water treatment has excellent defoaming and foam inhibition performance and good water dispersibility.

The invention discloses a xanthophyll-nicotinamide eutectic crystal and a preparation method and application thereof, the eutectic crystal is formed by xanthophyll and nicotinamide according to the molar ratio of 1: 1 through intermolecular interaction of hydrogen bonds, Van der Waals force and the like, and the molecular formula is C46H62N2O3. According to the invention, xanthophyll and nicotinamide are combined through a co-crystal technology, a novel co-crystal with good water solubility and high bioavailability is formed, and the solubility and absorption efficiency of xanthophyll are significantly improved.

The invention discloses a multi-site intelligent response type CO2 gas channeling prevention gel and a preparation method, and belongs to the field of chemical oil displacement, and the preparation method comprises the following steps: taking a carbon dioxide response type monomer, acrylamide and sodium acrylate as monomers, and adopting water-soluble free radical polymerization to prepare a CO2 response type copolymer; the CO2 response type copolymer, a cross-linking agent, a stabilizer, a retarder and formation water are prepared into a polymer cross-linking agent mixed solution, a cross-linking reaction is carried out under the conditions of formation temperature and mineralization degree, and the multi-site intelligent response type CO2 gas channeling prevention gel is obtained. The gel effectively solves the problems that a traditional anti-channeling agent is poor in injectivity in a low-permeability and ultra-low-permeability oil reservoir and cannot achieve deep channeling sealing, CO2 gas channeling fractured channels can be effectively blocked, the carbon dioxide oil displacement effect is remarkably improved, and key technical support is provided for large-scale application of carbon dioxide displacement.

The invention provides a preparation method of high-viscosity water-soluble melamine formaldehyde resin, which comprises the following steps: adding a first part of formaldehyde solution and water into a reaction kettle, fully and uniformly stirring, adjusting the pH value of the system in the reaction kettle, and controlling the reaction temperature in the reaction kettle at 25-30 DEG C; adding polyvinyl alcohol into the reaction kettle, raising the temperature in the reaction kettle to 48-52 DEG C, and keeping the temperature for 10-30 minutes; slowly raising the temperature in the reaction kettle to 90 DEG C, adding melamine and an environment-friendly accelerant into the reaction kettle, stirring and preserving heat for 8-12 minutes, and adding a melamine prepolymer modifier into the reaction kettle; adding a first part of formaldehyde solution into the reaction kettle, controlling the reaction temperature in the reaction kettle to be 92-95 DEG C, adding a second part of formaldehyde solution into the reaction kettle after reacting for 10 minutes, continuously stirring, and controlling the reaction temperature in the reaction kettle to be quickly reduced to 58-62 DEG C; and adding urea into the reaction kettle, naturally cooling to room temperature, and discharging glue. The melamino-formaldehyde resin prepared by the invention has the advantages of high viscosity, good water solubility, low free formaldehyde and longer storage life.

The invention relates to the technical field of degradable materials, and discloses a water-soluble degradable fiber and a preparation method thereof. The water-soluble degradable fiber disclosed by the invention is prepared by taking polylactic acid as a main matrix, adding modified sodium lignin sulfonate, polyvinyl alcohol and polyethylene wax, blending, carrying out melt extrusion, and carrying out melt spinning. The fiber has water solubility, degradability, sand carrying performance and salt resistance, and has a good application prospect in a fracturing fluid used in a well drilling fracturing process based on the advantages of water solubility, degradability, sand carrying performance and salt resistance.

A membrane-less electrolyzer for converting a liquid feed to one or more useful products is disclosed. The membrane-less electrolyzer comprises an anode, a cathode and an internal flow plate separating the anode and the cathode at internal sides thereof. The internal flow plate has an open area formed therein arranged to permit fluid communication between an internal face of an anode and an internal face of a cathode. The internal flow plate comprises at least one fluid inlet configured to direct a liquid flow to the open area. In some embodiments, a hydrophobic film layer is arranged between the anode and an anode flow plate. The hydrophobic film layer may be selectively permeable to species with low water solubility. A method of converting (bi)carbonate solution to one or more carbon-containing compounds using the membrane-less electrolyzer is also disclosed.

The invention discloses an anguilla anguilla antibacterial peptide Anguinin and application thereof. The amino acid sequence of the anguilla anguilla antibacterial peptide Anguinin is shown as SEQ ID NO. 01. The amino acid sequence consists of 18 amino acid residues, and the molecular weight of the amino acid sequence is 2091.41 Daltons. According to the prediction of a HeliQuest tool, the net charge number is + 5, the hydrophobicity value is 0.267, and meanwhile, good water solubility is shown. As a typical cationic polypeptide with positive charges, the cationic polypeptide has the remarkable advantages of being easy to chemically synthesize, wide in antibacterial spectrum, efficient in antibacterial activity, high in safety and the like, a solid foundation is laid for practical application of the cationic polypeptide in the fields of pharmacy and feed addition due to the characteristics, and wide commercialization prospects are shown.

The invention relates to a dihydroartemisinic acid inclusion compound as well as a preparation method and application thereof. The dihydroarteannuic acid clathrate compound comprises dihydroarteannuic acid and a cyclodextrin compound wrapping the dihydroarteannuic acid. The cyclodextrin compound comprises cyclodextrin and / or a cyclodextrin derivative. According to the invention, the inclusion effect of the cyclodextrin compound on the dihydroarteannuic acid is utilized, so that dihydroarteannuic acid molecules are embedded in the tubular structure of the cyclodextrin compound, and the water solubility of the dihydroarteannuic acid is greatly improved.

The invention provides liquiritin gel as well as a preparation method and application thereof. The liquiritin gel is prepared from the following components in concentration: 0.1 weight percent to 2 weight percent of liquiritin, 0.1 weight percent to 4 weight percent of carbomer, 0.1 weight percent to 4 weight percent of water-soluble cellulose ether compounds and 1 to 10 mL / Kg of triethanolamine. Wherein liquiritin and the water-soluble cellulose ether compound are respectively used as a main thickening agent and an auxiliary thickening agent, a synergistic thickening system is more stable and more suitable for liquiritin compared with a single thickening system or other neutralization systems, and the liquiritin and the water-soluble cellulose ether compound can synergistically adjust viscosity; triethanolamine is used as a neutralizer to neutralize carboxyl of carbomer to form gel; carbomer and a water-soluble cellulose ether compound are cooperated according to a specific ratio and can be different from a single thickening system or different neutralization systems, so that the liquiritin gel with excellent film-forming property, proper flowability and high transdermal absorption efficiency is prepared.

The invention relates to a method for preparing lithium dihydrogen phosphate from a lithium-containing solution by using an extraction-reverse extraction technology, an extraction agent adopted in the method comprises a main extraction agent, a synergistic extraction agent and a diluent, the pKa value of the main extraction agent is 2.2-7, the synergistic extraction agent has a P = O group or a cavity diameter of 0.12-0.15 nm, the water solubility of the synergistic extraction agent is less than or equal to 50 mg / L, and the diluent is a diluent. The synergistic extraction factor R of the extraction agent is more than 100, R = Dmix / (D1 + D2), Dmix is the extraction distribution ratio of the main extraction agent to the lithium when the main extraction agent and the synergistic extraction agent are mixed according to the mass ratio of 1: 1-1: 2, D1 is the extraction distribution ratio of the main extraction agent to the lithium, D2 is the extraction distribution ratio of the synergistic extraction agent to the lithium, and the stripping agent is phosphoric acid. According to the method disclosed by the invention, by selecting the main extraction agent and the synergistic extraction agent, on one hand, lithium monohydrogen phosphate and lithium phosphate impurities cannot be generated by reaction when phosphoric acid is adopted for reverse extraction, and on the other hand, higher separation degree on sodium and potassium can be achieved during extraction, so that high-purity lithium dihydrogen phosphate can be efficiently prepared.

The invention discloses a polylipoic acid-based composite sponge wound dressing and a preparation method and application thereof.The preparation method comprises the following steps that polylipoic acid amide with amino is obtained through disulfide bond ring opening polymerization, and the polylipoic acid amide and an aldehyde cross-linking agent are jointly dissolved in ethyl alcohol to form a solution A; carrying out high-speed shearing, dispersing and foaming on the water-soluble polymer, and freeze-drying to form porous sponge B; the porous sponge B is soaked in the solution A to be subjected to a cross-linking reaction, vacuum drying is conducted, and the polylipoic acid-based composite sponge wound dressing is obtained. The preparation method has the characteristics of simple preparation process, safety and no toxicity, the polylipoic acid with excellent oxidation resistance is introduced into the medical sponge material, the preparation method of the polylipoic acid medical porous structure material is obtained, the oxidation resistance and the wet viscosity of the medical sponge material are improved, and the medical sponge material has good application prospects. The application of the polylipoic acid-based porous material in the fields of hemostatic materials and wound dressings is realized.

The invention discloses a salicylic acid-cyclodextrin-amino acid ternary inclusion compound and a preparation method thereof. The salicylic acid-cyclodextrin-amino acid ternary inclusion compound is formed by salicylic acid, amino acid and a cyclodextrin derivative through non-covalent bond interaction, the cyclodextrin derivative is a cross-linked beta-cyclodextrin polymer, salicylic acid molecules are included in a cavity of the cross-linked beta-cyclodextrin polymer, and the cross-linked beta-cyclodextrin polymer is a cross-linked beta-cyclodextrin polymer. And meanwhile, guanidyl or carboxyl of an amino acid side chain interacts with hydroxyl outside the cross-linked beta-cyclodextrin polymer or an exposed part of an included salicylic acid molecule. According to the invention, a cross-linked beta-cyclodextrin polymer is used, arginine is introduced as a synergist, a salicylic acid-cross-linked beta-cyclodextrin polymer-arginine ternary clathrate compound is constructed, and through charge neutralization and hydrogen bond network synergistic effect, clathration efficiency is significantly improved, and water solubility of salicylic acid is improved.

The invention belongs to the field of nano-medicine and traditional Chinese medicine, and particularly discloses an antioxidant nano-material based on self-assembly of traditional Chinese medicine and copper ions and a preparation method thereof.The nano-material is prepared from BPCu nano-particles formed by self-assembly of berberine and procyanidine B2 under induction of the copper ions, the BPCu nano-particles are further subjected to surface modification through polyvinylpyrrolidone, and the antioxidant nano-material is prepared. And the stably dispersed PVP-coated BPCu nano structure is obtained. The material is small in particle size, uniform in distribution, good in water solubility and storage stability, excellent in free radical scavenging capacity and catalase-like activity and suitable for adjuvant therapy of oxidative stress related diseases, and the preparation method is easy and convenient to operate, does not need an organic solvent and has good industrialization and disease treatment potential.

The invention provides a low-molecular soluble chelating collector as well as a preparation method and application thereof, and belongs to the technical field of mineral processing. According to the collecting agent, low-molecular-weight ethylene glycol terephthalate serves as a precursor, and isosorbide is introduced for a copolymerization reaction; glutamic acid is introduced as a branched chain unit, and the branching degree and reaction active site density of the molecular structure are remarkably improved by utilizing the polyfunctional group characteristic of glutamic acid. A rigid ring structure and an ether bond of the isosorbide endow the medicament with good water solubility and dispersity, and invalid curling of a macromolecular chain is avoided; the introduction of glutamic acid branched chains greatly increases the number of hydroxyl groups and amino groups capable of reacting with carbon disulfide, so that each molecule carries more xanthate groups, and the adsorption stability and coverage density of the molecule on the surface of arsenopyrite are enhanced. By means of the structure, xanthate functional groups are fully exposed, multi-tooth chelation is easily conducted on the xanthate functional groups and iron and arsenic ions on the surface of arsenopyrite, a strong hydrophobic surface layer is formed, and therefore the collecting selectivity is remarkably improved.

The invention discloses a water-soluble bornyl ester compound and application thereof, the structure of the water-soluble bornyl ester compound is as shown in general formula I, R is acetic acid 2-oxoethyl ester of organic heterocyclic ring, amino acid 2-oxoethyl ester, glycolate of amino acid, acetal of monodisperse polyethylene glycol chain, carbonate, ester or glycosyl; the compound is good in water solubility, the problems that borneol is difficult to dissolve in water and difficult to prepare can be well solved, and in an inflammatory depression animal model, the bornyl ester compound shows good anti-inflammatory, anti-depression and cerebral apoplexy treatment effects and has great application prospects.

The invention discloses application of sulfur quantum dot nanoparticles to improvement of plant waterlogging resistance. The invention provides sulfur quantum dot nanoparticles PEI-SQDs prepared from sulfur, sodium hydroxide, polyethylene glycol and polyethyleneimine. The sulfur quantum dot nanoparticles PEI-SQDs are simple in synthesis method, small in particle size, low in toxicity, low in price, simple to prepare, suitable for large-scale production, good in water solubility and good in biocompatibility; the compound has the capacity of removing active oxygen and ethylene in vitro, and can remove excessive active oxygen and ethylene in plants with waterlogging stress, relieve short-term waterlogging stress suffered by crops and recover growth and development of the crops when being applied to the plants with waterlogging stress; further, long-term waterflooding stress on the crops can be relieved, and the yield of the crops is increased; and the sulfur quantum dot nanoparticles are simple and convenient in use method and obvious in action effect.

The present invention discloses a sea dragon-derived antimicrobial peptide, SsPle, for antimicrobial applications in the complex environments of tropical islands and reefs. The amino acid sequence of this antimicrobial peptide is shown in SEQ ID NO. 3. This antimicrobial peptide, SsPle, exhibits good water solubility, broad antimicrobial activity, and highly stable antimicrobial properties under high temperature, high salt, and ultraviolet irradiation conditions. It can inhibit the release of free bacterial endotoxins and has significant application prospects as an eco-friendly antimicrobial agent in the unique environments of South China Sea islands and reefs.

Coating compositions prepared from an aqueous formulation of (1) one or more metal silicates, (2) one or more metal oxides, (3) one or more water soluble caustic agents; and (4) water are disclosed to form fire resistant coatings. In some implementations, the coating composition can be free of, or substantially free of, large solid particles comprised of the metal silicate, metal oxide and water-soluble caustic agent.

The invention is directed to a biodegradable, thermoplastic multiblock copolymer, to a process for preparing a biodegradable, thermoplastic multiblock copolymer, to the use of a biodegradable thermoplastic multiblock copolymer, to a composition for the delivery of at least one pharmacologically active compound to a host, and a medical device comprising a biodegradable, thermoplastic multiblock copolymer. The biodegradable, thermoplastic multiblock copolymers of the invention comprise at least one prepolymer (A) segment and at least one hydrolysable amorphous prepolymer (B) segment, wherein the segments are linked by a multifunctional chain extender, wherein the at least one prepolymer (A) segment comprises: a) one or more hydrolysable linkages, b) a water-soluble polyoxazoline-based polymer, and c) reaction products of one or more cyclic monomers and / or one or more non-cyclic monomers, wherein the water-soluble polyoxazoline-based polymer is a polymer containing a repeating unit of structure −[N(COR1)CH2CH2]n− where R1 is independently selected for each repeating unit from an alkyl group and n is 3-100, and wherein the multiblock copolymer is amorphous.

The invention relates to the field of packaging materials, in particular to a high-temperature-resistant water-soluble polyvinyl alcohol packaging film as well as a preparation method and application thereof. The high-temperature-resistant water-soluble polyvinyl alcohol packaging film is prepared from the following raw materials: polyvinyl alcohol, modified polyvinyl alcohol, a compound composition, modified nanoparticles, a surfactant, deionized water and the like. The finally prepared film material not only has good mechanical properties, but also can maintain good water solubility, barrier property and other properties while having excellent high temperature resistance, solves the contradictory problem that the high temperature resistance of the existing PVA film is changed by sacrificing other properties, avoids the complex process of multi-layer co-extrusion film formation, and is suitable for large-scale production. And the equipment cost is further saved, the comprehensive performance requirements of the existing packaging field on the PVA film are met, and the method has very excellent application prospects.

The invention relates to natural dye and green chemical industry, and particularly discloses water-soluble biological indigo blue and a preparation method thereof. The water-soluble biological indigo comprises the following raw material components in parts by weight: 80-90 parts of a biological-based indigo concentrated solution; 0.5 to 1 part of dimethyl sulfoxide; 10 to 15 parts of a solubilizer A; 5-10 parts of a solubilizer B; and 10 to 15 parts of deionized water. According to the invention, the bio-based indigo concentrated solution synthesized by a biological method is used as a raw material, the water-soluble compound is innovatively formed through beta-cyclodextrin inclusion and povidone compounding, and the water-soluble compound has relatively high water solubility; the water solubility of the product is greater than or equal to 50g / L, the stability is excellent, the obtained indigo dye is natural in source, environment-friendly and high in water solubility, secondary pollution of the traditional dye to the environment is avoided, and the indigo dye is suitable for sustainable chemical industry and green dyeing and finishing industries and can be widely applied to the fields of textile dyeing, water-based ink, cosmetic color developing agents, medicines and the like.

The invention relates to a high-water-solubility denitroflavin covalent complex as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis and medicinal chemistry. Comprising the following steps: (1) firstly, carrying out bromination reaction on 3-methyl-10-ethyl denitroflavin, so as to obtain 3-methyl-10-(1-bromoethyl) denitroflavin; and (2) coupling the 3-methyl-10-(1-bromoethyl) denitroflavin with vitamin C, so as to obtain the high-water-solubility denitroflavin covalent complex. According to the present invention, the prepared highly water-soluble denitrificin covalent complex has the two-phase solubility of the organic solvent and the water, such that the water solubility of the 3-methyl-10-ethyl-denitrificin is substantially enhanced, and the application range of the denitrificin is expanded. And meanwhile, the denitrified flavin covalent compound also has good antioxidant activity, and the antioxidant duration can be prolonged.