10182 results about "Aqueous solubility" patented technology

An acid fracturing method is provided in which the acid is generated in the fracture by hydrolysis of a solid acid-precursor selected from one or more than one of lactide, glycolide, polylactic acid, polyglycolic acid, a copolymer of polylactic acid and polyglycolic acid, a copolymer of glycolic acid with other hydroxy-, carboxylic acid-, or hydroxycarboxylic acid-containing moieties, and a copolymer of lactic acid with other hydroxy-, carboxylic acid or hydroxycarboxylic acid-containing moieties. The solid acid-precursor may be mixed with a solid acid-reactive material to accelerate the hydrolysis and/or coated to slow the hydrolysis. Water-soluble liquid compounds are also given that accelerate the hydrolysis. The method ensures that the acid contacts fracture faces far from the wellbore.

The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

The present invention provides pharmaceutical compositions for controlled release of pharmaceutically active agents, especially those with a high water solubility, high dose, and/or short half-life. In addition, the present application provides methods for preparing and using such pharmaceutical compositions.

The present invention relates to oil-in-water mascara compositions comprising water-insoluble polymeric materials in the form of an aqueous emulsion, water-soluble, film-forming polymers and organophilic clays. Said compositions exhibit improved wear and are removable with soap and water.

An aqueous binder composition containing a water-soluble and substantially infinitely water-dilutable free radical polymerized adduct of a monomeric carboxylic acid component and a monomeric hydroxyl component, polymerized in the presence of a chain transfer agent, and the related method of its use for making glass fiber products, especially fiberglass insulation.

An aqueous ink comprises water, a water-insoluble coloring material, and plurality of water-soluble organic solvents and the plurality of water-soluble organic solvents including a good medium or good mediums for the water-insoluble coloring material and a poor medium or poor mediums for the water-insoluble coloring material. The ratio of the content of the poor medium and the content of the good medium is in a specific range. A water-soluble organic solvent showing the maximum Ka value out of respective Ka values of the plurality of water-soluble organic solvents is the poor medium. When the aqueous ink is in contact with a specific reaction liquid, the dissolution state or dispersed state of the water-insoluble coloring material in the ink is made unstable. As a result, an image which has a sufficiently large area factor even with a small amount of ink droplets and is excellent in image density, bleeding resistance, and fixability can be obtained. In addition, the aqueous ink is excellent in storage stability.

The invention relates to a method of preparing an electrochemical electrode which is partially or totally covered with a film that is obtained by spreading an aqueous solution comprising a water-soluble binder over the electrode and subsequently drying same. The production cost of the electrodes thus obtained is reduced and the surface porosity thereof is associated with desirable resistance values.

The invention relates to microcapsules, and a continuous micro-encapsulation water-in-oil-in-water microencapsulation process through in situ and interfacial polymerization of the emulsion. The formulation comprises a continuous water phase having a dispersion of microcapsules which contain oil drops and wherein the inside of each oil phase drop -containing optionally oil-soluble materials- there is a dispersion of water, or aqueous extract or water dispersible material or water soluble material. The oil drops are encapsulated with a polymerisable material of natural origin. Such microcapsules are appropriated for spray-dry processes, to be used as dry powder, lyophilised, self-emulsifiable powder, gel, cream and any liquid form. The active compounds included in te microcapsules are beneficial to the health and other biological purposes. Such formulations are appropriate to be incorporated in any class of food, specially for the production of nutraceuticals, as well as cosmetic products (such as rejuvenescence creams, anti-wrinkle creams, gels, bath and shower consumable products and sprays). The preparations are adequate to stabilise compounds added to the food, media for cultivating microbes and nutraceuticals, specially those which are easily degradable or oxidizable.

The present invention provides for compositions and methods that may offer protection from irritants, as well as antimicrobial protection. Preferred embodiments of the invention include topical antimicrobial compositions comprising two or more water-soluble zinc salts in low concentrations.

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.

A molded component or article for biomedical use is prepared from a crosslinkable non-water-soluble polymer which when crosslinked and saturated with water forms a hydrogel. The polymer is formulated as a composition containing a non-aqueous diluent in addition to the polymer, the diluent being present in a volumetric proportion that is substantially equal to the volumetric proportion of water in the hydrogel that would be formed when the polymer is crosslinked and saturated with water. The composition is cast in a mold where the composition is exposed to conditions that cause crosslinking to occur by a reaction to which the non-aqueous diluent is inert. The crosslinking reaction produces a molded non-aqueous gel which is then converted to a hydrogel by substituting an aqueous liquid such as water or physiological saline for the non-aqueous diluent. The use of a molding composition whose curing consists essentially entirely of crosslinking results in a molding process that entails little or no shrinkage, and dimensional integrity is maintained up through the formation of the hydrogel by using the non-aqueous diluent in essentially the same volumetric proportion as water in the hydrogel.

Pharmaceutical formulations comprising: a compound of low water solubility, having a maximum average particle size; a carrier; and at least two surface stabilizers are disclosed. The present invention also comprises methods of treating various conditions with such a formulation and processes for making such a formulation.

A method of treating a treatment zone in a well to reduce the permeability of the treatment zone including the steps of: introducing into the treatment zone a water-based treatment fluid comprising: an aqueous silica sol; and a water-soluble chemical activator for gelling the silica sol, wherein the chemical activator is selected from the group consisting of: phytic acid, methylglycinediacetic acid, a water-soluble polyepoxysuccinic acid, salicylic acid, ascorbic acid, tannic acid, and an alkali metal salt or ammonium salt of any of the foregoing; and shutting in treatment zone for at least a sufficient time to allow the treatment fluid to in-situ form a solid gel at a design temperature for the method. Alternatively, a first treatment fluid including the aqueous silica sol and a second treatment fluid including the chemical activator can be introduced into the treatment zone separately, in any order.

A pharmaceutical composition comprises a drug-carrier system having a small-molecule drug of low water solubility, e.g. N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea (ABT-869), and (+)-1-(5-tert-butyl-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102), in solution in a substantially non-aqueous carrier that comprises at least one phospholipid and a pharmaceutically acceptable solubilizing agent. The drug-carrier system, when mixed with an aqueous phase, typically forms a non-gelling, substantially non-transparent liquid dispersion. The composition is suitable for administration by a suitable route, e.g. orally, to a subject in need thereof.

Advantageous aqueous mixed salt systems viscosified with water-soluble or water-dispersable polymers which are superior to corresponding single salt systems of similar densities are provided. The mixed salt systems comprise water; a water-soluble or water-dispersable polymer capable of viscosifying an aqueous medium; one or more cations including a member selected from the group consisting of lithium, sodium, potassium, cesium, magnesium, calcium, zinc, or mixtures thereof; and one or more anions including a member selected from the group consisting of chloride, bromide, iodide, formate, nitrate, acetate, cyanate, thiocyanate, a zinc complex anion or mixtures thereof; there being present either at least two cations or at least two anions. Inventive viscosified mixed salt systems display-under such stressing factors as aging, heat, mechanical agitation, and shear-greater stability compared to the single salt systems of similar densities. Also provided are methods for making viscosified mixed salt systems and methods for advantageously using the same as drilling, drill-in, completion, hydraulic fracturing, work-over, packer, well treating, testing, spacer, or hole abandonment fluids.

The invention belongs to the technical field of nanoporous material, namely carbon aerogel, and particularly relates to graphene oxide-crosslinked polyimide-based carbon aerogel and a preparation method thereof. The invention carbon aerogel is prepared by crosslinking polyamide acid aerogel by graphene oxide, and comprises the components of graphene oxide and one or more water-soluble polyimide precursor-polyamide acids. The preparation method comprises the following steps: mixing an aqueous graphene oxide solution with the water-soluble polyimide precursor-polyamide acid, and preparing graphene oxide/polyamide acid aerogel through sol-gel and freeze-drying processes; preparing the graphene/polyimide-based carbon aerogel through thermal imidization and high temperature carbonization. According to the preparation method, a toxic reagent formaldehyde is not used; the prepared carbon aerogel has a mesoporous, microporous and macroporous three-level three-dimensional network porous structure, high specific surface area, high conductivity and stable physical and chemical properties, and is an ideal electrode material for preparing a supercapacitor and other new energy devices and a high-performance adsorbent material.

The present invention is directed to the oral osmotic delivery of therapeutic compounds that have limited solubility in an aqueous environment due to inherent hydrophobicity or to saturation limitations in the core of the osmotic system. The present invention is suitable for the osmotic delivery of glipizide and other hydrophobic drugs, but runs the spectrum to other therapeutic agents with higher aqueous solubilities, yet having a solubility limitation in an osmotic dosage unit due to high drug load.

Compositions, methods and kits for purifying and clarifying and/or nutrifying contaminated drinking water and which comprise a primary coagulant material, a microbiocidal disinfectant and an oxidant system. Highly preferred compositions also contain one or more of a bridging flocculent material, the levels and ratios of coagulant to flocculent preferably falling within certain ranges, a cationic coagulant aid, especially chitosan, a water-soluble alkali, a water-insoluble silicate, and a food additive or nutrient source. The purified water remains free of discoloration for extended periods of storage.