213 results about "Cyclodextrin polymer" patented technology

This invention discloses methods for preparing compositions of cyclodextrin polymers for carrying drugs and other active agents. Methods are also disclosed for preparing cyclodextrin polymer carriers that release drugs under controlled conditions. The invention also discloses methods for preparing compositions of cyclodextrin polymer carriers that are coupled to biorecognition molecules for targeting the delivery of drugs to their site of action. The advantages of the water soluble (or colloidal) cyclodextrin polymer carrier are: (1) Drugs can be used that are designed for efficacy without conjugation requirements. (2) It will allow the use of drugs designed solely for efficacy without regard for solubility. (3) Unmodified drugs can be delivered as macromolecules and released within the cell. (4) Drugs can be targeted by coupling the carrier to biorecognition molecules. (5) Synthesis methods are independent of the drug to facilitate multiple drug therapies.

The invention relates to an AM / NaAA / allyl cyclodextrin polymerization with a inclusion function and a synthesis method of the AM / NaAA / allyl cyclodextrin (CD) polymerization, which comprises three structure units of acrylamide, sodium acrylate and allyl cyclodextrin. The synthesis method is as follow: the allyl cyclodextrin is synthesized with DMSO and DMF as solvent, CD as raw material and under the temperature of 0 to 10 DEG C. Then AM is put into the allyl-beta-cyclodextrin water solution, then initiator is added to prepare AM / allyl-beta-cyclodextrin binary copolymer under the conditions that monomer concentration is 10 to 20 percent, initiation system concentration is 40 to 80 mg / l, the temperature is 30 to 50 DEG C, and the time is for 1 to 8 hours. NaOH solution is put into the binary copolymer to hydrolyze, then the AM / NaAA / allyl cyclodextrin polymerization is obtained. The synthesis method of the polymer is processed under the mild condition with simple operation, the product is easy to be purified and separated. The AM / NaAA / allyl cyclodextrin polymerization can be used in the fields such as petroleum exploitation, waste water treatment, chemistry and medicine.

The invention belongs to the technical field of membranes, and particularly provides an anti-pollution cyclodextrin-polymer composite nano-filtration membrane and a preparation method thereof. The cyclodextrin-polymer composite nano-filtration membrane is prepared by compounding a cyclodextrin-containing aromatic polymer functional cortex on a porous support membrane by virtue of an interfacial polymerization method. In the nano-filtration membrane, the porous support membrane is immersed in an oil-phase solution, in a cyclodextrin-containing aqueous-phase solution and in the oil-phase solution; and the cyclodextrin is loaded to the composite membrane functional cortex by virtue of interfacial polymerization, and the structure is stable. The preparation method has a simple operation process and mild reaction conditions; and by virtue of the annular cavity structure of the cyclodextrin and massive hydroxy carried by the cyclodextrin, the water flux, hydrophilicity and pollution resistance of the membrane are improved.

The invention relates to an AM (Acrylamide) / DMDAAC (Dimethyl Diallyl Ammonium Chloride) / cyclodextrin polymer filtrate reducer used in petroleum and gas drilling fluid and a preparation method thereof. The invention can solve the technical problems that a well wall is not stable as water loss increases at the pit bottom under the condition of high temperature, and the like. The AM / DMDAAC / cyclodextrin polymer filtrate reducer is characterized by comprising three monomers of AM, DMDAAC and cyclodextrin; the preparation method comprises the following steps of: firstly adding the AM and the DMDAAC into an allyl cyclodextrin water solution according to the mol ratio among the allyl cyclodextrin water solution, the AM and the DMDAAC of 69.2-84.2:30-15:0.8 in sequence; then adding a chelating agent, an oxidant and a reducing agent in sequence; finally evenly mixing, then injecting nitrogen for 20-40min and deoxidizing, and reacting at 30-50 DEG C for 6-8h to obtain the AM / DMDAAC / cyclodextrin polymer filtrate reducer. The preparation method of the polymer is simple, convenient and available and mild in reaction conditions; and the polymer has good filtrate reduction effect in the drilling fluid, is resistant to temperature up to more than 250 DEG C and used in the petroleum and gas drilling fluid.

A targeting conjugate is provided comprising an active agent, one or more residues of a cyclodextrin (CD)-containing polymer and a biorecognition molecule. The polymer is preferably a peptide or a polypeptide comprising at least one amino acid residue containing a functional side group to which at least one of the CD residues is linked covalently; the biorecognition molecule is covalently bonded directly or via a spacer to the polymer backbone of the CD-containing polymer; and the active agent is noncovalently encapsulated within the cavity of the cyclodextrin residues and / or entrapped within the polymer matrix of the CD-containing polymer.

The invention relates to a nitrogen-containing binder for sulfur-lithium batteries and a preparation method thereof. The binder is a nitrogen-containing cyclodextrin polymer water-based binder with a three-dimensional network structure. The existing three-dimensional network structure can well bear the mechanical pressure brought by sulfur-lithium batteries in the charging and discharging process due to volume change, introduced nitrogen-containing functional groups can effectively inhibit the problems of dissolution and shuttle effect of polysulfide ions in electrolyte, a number of hydroxyl groups exist in the cyclodextrin and have strong hydrogen-bond interaction with anode material particles, and the stability of pole pieces can be maintained. In addition, the binder also has a role of increasing guide ions. Therefore, the binder can effectively solve the problem that a positive polysulfide material in the sulfur-lithium batteries is unstable in organization structure, the utilization rate of composite material active matter and the rate capability of the active matter can be improved, and accordingly the specific power, specific energy and cyclicity of the batteries can be improved.

The invention provides a temperature-sensitive amphiphilic cyclodextrin polymer PCEC (polycaprolactone-polyethylene glycol-polycaprolactone, PCL-PEG-PCL). The polymer provided by the invention is the amphiphilic cyclodextrin polymer which is obtained by linking a PCL-PEG-PCL molecule with beta-CD (cyclodextrin) through utilizing the temperature-sensitive characteristic of a PCL-PEG-PCL triblock copolymer and the inclusion effect of beta-CD on a hydrophobic medicament, can effectively load and slowly release a hydrophobic or water-soluble medicament on the basis of the traditional hydrogel encapsulated water-soluble medicament, has proper critical gel temperature and can form in situ temperature-sensitive hydrogel after injection. According to the invention, the hydrophobic zone of the polymer is obviously enlarged, thereby effectively improving the loading capacity of the hydrogel on the hydrophobic medicament and obtaining high medicament encapsulation rate and medicament loading amount; and simultaneously, the controlled-release effect of the medicament after local injection delivery is realized by utilizing the temperature-sensitive gel performance of the polymer. The polymer provided by the invention has the following chemical structure shown in the specification.

A preparation method of a rose essence beta-cyclodextrin polymer microsphere inclusion compound comprises the following steps: preparing a beta-cyclodextrin polymer microsphere by an inverse emulsion polymerization method; dissolving rose essential oil in a small amount of anhydrous ethanol; including the solution with the beta-cyclodextrin polymer microsphere by a saturated aqueous solution method; and after completion of inclusion, eluting and performing vacuum decompressed drying to obtain an inclusion product. The preparation method of the rose essence beta-cyclodextrin polymer microsphere inclusion compound takes the beta-CD (cyclodextrin) as a matrix which is crosslinked by epichlorohydrin, and uses the beta-CD microsphere which is synthesized by the inverse emulsion polymerization method, so that not only the original cavity structure and the slow-release and controlled-release and identification capabilities of the beta-CD are kept, but also the hydrophobicity of a beta-CD cavity is improved, the inclusion is promoted and the inclusion rate is improved; and due to intermolecular synergistic inclusion after beta-cyclodextrin polymerization, so that rose essence and a substance with similar structure and solubility to the rose essence can be firmly clamped, thus playing a relatively good slow-release effect.

The invention relates to the field of functional materials, particularly a preparation method of an adsorbent for acid dye wastewater treatment. The invention mainly solves the technical problem that dyeing wastewater can not be easily decolorized, can not achieve the discharge standard and the like in the prior art. The preparation method comprises the following steps: putting 8-10g of beta-cyclodextrin into 1-2g of citric acid monohydrate, and adding 1g of PEG-400 and 0.25g of sodium dihydrogen phosphate to obtain a beta-cyclodextrin polymer by polymerization; adding a silane coupling agent into a chitosan solution; and cross-linking the beta-cyclodextrin polymer with the chitosan to obtain a beta-cyclodextrin-chitosan porous membrane, wherein the mol ratio of the chitosan to the beta-cyclodextrin polymer is 1:3..

The invention relates to a preparation method of a water-soluble ferrocene supramolecular inclusion compound, belonging to the field of preparation processes of water-soluble metal organic materials in the technical field of supramolecular materials. The preparation method comprises the following steps of: firstly crosslinking beta-cyclodextrin as a raw material with epoxy chloropropane to generate a beta-cyclodextrin polymer under a strong alkaline condition; and then carrying out homogeneous supramolecular reaction on the beta-cyclodextrin polymer as a subject molecule, ferrocene as an object molecule and glycol as a reaction solvent to generate the water-soluble ferrocene supramolecular inclusion compound. The preparation method has the advantages of easy and convenient operation, easy control of conditions, little environmental pollution and easy industrialization; the material not only has high water solubility, but also has stable structure without damaging the self structure of the ferrocene; and in addition, the water-soluble ferrocene supramolecular inclusion compound can be used in the fields of aqueous-phase electroanalytical chemistry, biological sensors, aqueous-phase organic synthesis, biological medicine, and the like because of good water solubility.

The invention discloses a beta-cyclodextrin polymer and a preparation method thereof as well as a method for treating cationic dye wastewater by using the beta-cyclodextrin polymer. The preparation method of the beta-cyclodextrin polymer comprises the following steps: carrying out polymerization reaction on beta-cyclodextrin (beta-CD), a crosslinking agent (tetrafluoroterephthalonitrile TFPN) anda basic salt compound into an organic solvent in the inert atmosphere; reacting the obtained polymer with sodium hydroxide, thereby obtaining a reaction product, namely a porous beta-cyclodextrin polymer (CDP-COOH). The porous beta-cyclodextrin polymer prepared by the preparation method disclosed by the invention can be used for quickly removing cationic dye contaminants such as methylene blue, malachite green, basic fuchsin, methyl violet and alkaline blackish green in water, and the adsorption rate of the beta-cyclodextrin polymer is greater than that of an activated carbon material. Besides, the polymer can be regenerated for multiple times under mild conditions, and the adsorption performance loss is smaller.

The present invention provides a preparation method and applications of an anion beta-cyclodextrin magnetic microsphere. The preparation method comprises: adopting a co-precipitation method to synthesize a Fe3O4 nanometer material under a weakly alkaline condition, adopting KH560 to modify the Fe3O4 nanometer material, dispersing the modified Fe3O4 nanometer magnetic fluid into a gelatinized beta-cyclodextrin, adopting epichlorohydrin as a cross-linking agent, adopting Na3P3O9 as an anionization modifier, adopting Span80 and Tween20 as emulsifiers, adopting kerosene as an oil phase, and adopting a reversed phase emulsion polymerization method to prepare the anion beta-cyclodextrin magnetic microsphere with characteristics of excellent heavy metal contaminant absorption performance, capability of being recovered, and recycling. The anion beta-cyclodextrin magnetic microsphere is mainly used in the fields of environment monitoring, sewage treatments and the like, wherein the pollution problem of heavy metal ions in sewage and other pollution sources can be well solved, effects of emission reduction and environmental protection can be provided, and survival environment conditions of people can be improved.

A direct compression formulation suitable for preparing buccal and / or sublingual and dosage forms incorporates a combination of a non-ionic polymeric solubility enhancer, a mucoadhesive polymer, a filler, a disintegrant, and a pharmaceutically active agent. Cannabinoid-cyclodextrin complexes exhibiting an improved property selected from improved stability, higher product yield and improved product uniformity may be obtained by complexing the cannabinoid with the cyclodextrin in a liquid medium containing an antioxidant. To enhance stability, product yield and / or product uniformity, complexing may be done while the liquid medium is in contact with an atmosphere having a very low oxygen content. The resulting complexes may be combined with decomplexing agents and / or dispersed in a matrix material comprised of a hydrogel-forming polymer to provide enhanced absorption of the cannabinoid through oral mucosa and reduced ingestion of the cannabinoid as compared with known commercially available cannabinoid-containing oral dosage forms.

The invention discloses a polymer system in controllable association strength. The polymer system comprises a subject cyclodextrin polymer and an object surfactant; the subject cyclodextrin polymer is selected from linear cyclodextrin polymer and modified Nano-SiO2 star-shaped macromolecule cyclodextrin polymer; the object surfactant is selected from adamantine-sodium octadecyl sulfate, adamantine-lauryl sodium sulfate, adamantine-cetyl sodium sulfate, benzyl-sodium octadecyl sulfate, benzyl-lauryl sodium sulfate and benzyl-cetyl sodium sulfate. In an application, the cyclodextrin polymer is prepared into an aqueous solution in the concentration of 0.1-0.5g / ml and then is mixed with the surfactant, the cyclodextrin advantage is utilized to wrap adamantine or benzene ring while the alkyl hydrophobic chain is exposed on the exterior of the cyclodextrin hydrophobic chamber, so that the polymer system in controllable association strength can be realized, the system viscosity is changed and the purpose of dynamically regulating the system viscosity can be achieved.

The invention discloses a beta-cyclodextrin compound, a preparation method thereof, and an application thereof in water treatment. The preparation method comprises the following steps: carrying out a primary substitution reaction on beta-cyclodextrin, a cross-linking agent and an alkaline compound in a solvent in inert atmosphere, adding carbon nitride, and carrying out a secondary substitution reaction to obtain the beta-cyclodextrin compound. The prepared porous beta-cyclodextrin polymer can rapidly include multiple organic micropollutants in water, and has a larger adsorption rate constant than active carbon and a non-porous beta-cyclodextrin sorbent material. The polymer can rapidly remove the multiple organic pollutants when the water contains the multiple organic micropollutants, so the polymer has a wide application range. Additionally, the polymer can be regenerated under mild conditions multiple times without performance loss.

The invention discloses a beta-cyclodextrin polymer and a preparation method thereof and an application method of the beta-cyclodextrin polymer in treatment of dye wastewater. The preparation method of the beta-cyclodextrin polymer comprises the steps of: performing a polymerization reaction on beta-cyclodextrin (beta-CD), a cross-linking agent (tetrafluoroterephthalonitrile, TFPN) and a basic salt compound in an organic solvent in an inert atmosphere so as to obtain a polymer, performing a reaction between the obtained polymer with ethanolamine (EA) to obtain a product which is the porous beta-cyclodextrin polymer (EA-CDP). Through the prepared porous beta-cyclodextrin polymer, methyl orange, congo red, acid blue 83, acid yellow G and other anionic dye pollutants in water can be removed quickly, and the beta-cyclodextrin polymer has an adsorption rate constant larger than that of an activated carbon material and low price; in addition, the beta-cyclodextrin polymer can be regeneratedmultiple times under mild conditions and has small loss of performance.

The invention relates to a method for preparing environmentally responsive monodisperse cyclodextrin polymer hollow microspheres. In the process of preparing multi-cavity poly (N-isopropylacrylamide-cyclodextrin) hollow microspheres, the hollow microspheres are endowed with environmental responsiveness, and in the process of preparing crosslinking cores, acid monomers are added to be copolymerized with NIPAM monomers so as to obtain acidic cores; and after cyclodextrin monomers and a crosslinking agent are added into the acidic cores so as to obtain core / shell-structured microspheres, the core / shell-structured microspheres are treated by using alkali liquor, and an ionization effect generated by acid-base neutralization accelerates the collapse of cores and the swelling of crosslinking shell layers, so that the permeability of the shell layers subjected to swelling is enhanced, therefore, a situation that PNIPAM (core) chains in the shell layers quickly escape so as to obtain microspheres is facilitated, and PNIPAM and acid ingredients in the microspheres also endow the hollow microspheres with pH and temperature responsiveness. The method disclosed by the invention solves the problems existing in hollow microsphere preparation implanted by using the existing 'self-removable' technique.

The invention relates to the technical field of sewage treatment, provides a preparation method and application of cyclodextrin polymer hydrogel, and aims at solving the problems that the conventionalhydrogel is capable of treating single pollutants, and is low in efficiency and small in application range. The preparation method is characterized in that beta-cyclodextrin is used as the raw material and is subjected to selective sulfonylation through toluene sulfochloride to obtain toluenesulfonyl-beta-cyclodextrin; then the toluenesulfonyl-beta-cyclodextrin is subjected to thiourea substituting to obtain hydrosulphonyl grafted beta-cyclodextrin; finally, the hydrosulphonyl grafted beta-cyclodextrin is processed according to a suspension emulsion polymerizing method to obtain the novel two-functional polymer hydrogel. The hydrogel prepared according to the method is applicable to a complex sewage system integrating phenol and heavy metal ions. The hydrogel is capable of efficiently synchronously adsorbing two pollutants including phenol and the heavy metal ions, and is wide in application range and high in adsorption efficiency.

The invention relates to a method for preparing a rod-like imprinted polymer capable of efficiently separating naringin in a water phase. The rod-like imprinted polymer which is an adsorption material having specific recognition capability for naringin organic molecular medicaments with =O and -OH groups can be prepared by an emulsion polymerization method, with the naringin, hesperidin, the naringin or dihydrochalcone as an imprinting molecules, cyclodextrin as a functive and hexamethylene diisocyanate as a cross-linking agent. The prepared rod-like imprinted cyclodextrin polymer has larger specific area and pore volume, benefits the contact of a substrate with a combined locus and improves the capacity. The rod-like molecular imprinted polymer (RMIP) has high affinity and selectivity to the naringin (NG). When the concentration of the NG is 0.02mg / ml, the imprinted molecule alpha reaches 1.53.

The invention discloses a beta-cyclodextrin polymer adsorbent applicable to adsorption of dye and heavy metal ions, and a preparation method and application thereof. According to the method, modifiedbeta-cyclodextrin, obtained by reaction between a silane-protected beta-cyclodextrin derivative and alkenyl anhydride, and heterocyclic olefinic monomers are subjected to free-radical crosslinking copolymerization to obtain the beta-cyclodextrin polymer adsorbent, wherein the structural general formula is shown in the description. The porous large-specific-surface copolymer can be formed during copolymerization between the modified beta-cyclodextrin and the heterocyclic olefinic monomers, and different adsorption sites are provided for the organic dye and the heavy metal ions, so that the adsorption capacity of the adsorbent can be improved greatly, and the mutual inhibition of the organic dye and the heavy metal ions as wells as the poor removal effect can be relieved effectively.

The invention discloses a method for preparing aerogel with beta-cyclodextrin polymers. The method includes sequentially adding secondarily re-crystallized beta-cyclodextrin, polyethylene glycol and epichlorohydrin into sodium hydroxide solution and carrying out stirring reaction until hydrogel is formed; carrying out cold storage and soaking treatment on the hydrogel; carrying out freezing and freeze-drying treatment on the hydrogel to obtain the aerogel. The method has the advantages that processes are flexible, simple and convenient and are low in cost and short in gelation time; the polyethylene glycol is used as a soft-segment polymer, accordingly, the properties of the aerogel with the beta-cyclodextrin polymers further can be regulated and controlled, the apparent density of the aerogel prepared by the aid of the method can be regulated and controlled in the range of 0.1-0.7 g / cm<3>, and the aerogel is of a stable gel skeleton structure; the aerogel is high in porosity and has large specific surface areas and basic three-dimensional network structures, the catalytic, recognition, inclusion and sustained-release capacity of cyclodextrin can be kept, and the aerogel has specific adsorption capacity for aromatic organic matters such as toluene and aniline.

The invention discloses a chiral chromatographic stationary phase of polymer-coated silica and a preparation method thereof, belonging to the technical field of the material chemistry. The chromatographic stationary phase has the structure that a grafted azide group is grafted on the surface of a silica microsphere with a cyclodextrin polymer layer. The preparation method adopted by the chiral chromatographic stationary phase of the polymer-coated silica comprises the steps of coating a polymer layer containing alkynyl on the surface of the silica microsphere by adopting an atom transfer redical polymerization, taking methacrylic acid-methyl-butyne alcohol ester as an monomer, taking divinylbenzene as a cross-linking agent, and then clicking chemically grafted cyclodextrin containing the azide group to obtain the chiral chromatographic stationary phase. The chiral chromatographic stationary phase of the polymer-coated silica has the advantages that the polymer coating layer in the stationary phase has favorable controllability and strong solvent resistance, and also has the advantages of high column efficiency, good chiral separation effect and wide application scope.

The invention discloses a method for preparing benzaldehyde by using cyclodextrin polymer to catalyze the oxidation of cinnamic aldehyde or cinnamon oil. The method comprises the following steps: taking the cinnamic aldehyde or the cinnamon oil as raw materials, adopting the cyclodextrin polymer as a catalyst, taking one of hydrogen peroxide, sodium hypochlorite or tert-butyl hydroperoxide as an oxidizing agent, taking water as a solvent, controlling the reaction temperature to be 30-90 DEG C, after finishing the reaction, using an ester solvent, methyl alcohol, acetone or acetonitrile to conduct extraction, and obtaining the benzaldehyde by decompression and concentration. The method has the advantages of simple technique, mild reaction condition, low cost, high yield, high natural levelof the benzaldehyde, environment friendliness, easily-separable catalyst with reusability and the like.

The invention relates to a preparation method of beta-cyclodextrin stabilized embedded nanoscale zero-valent iron. According to the method, beta-cyclodextrin is used a main raw material, and epichlorohydrin is used as a cross-linking agent; nanoscale zero-valent iron is subjected to cross-linking embedding under an alkaline condition, and the influence of the additive amount of the alkali on the formation and the performance of an embedding product is researched; the research shows that 40 percent NaOH solution has the best embedding effect and the best removal effect to Cd<2+>. The beta-cyclodextrin stabilized embedded nanoscale zero-valent iron prepared by the invention is environment-friendly, safe and non-toxic, has higher reaction activity and stability, and can be stably stored in air for several months, the storage, the transportation and the actual application of the nanoscale zero-valent iron are facilitated, and the method has excellent social benefit and environment benefit.

The invention relates to the field of wastewater treatment, in particular to a method for preparing a treating agent for aromatic hydrocarbon pollutants in organic wastewater. A method for producing a crosslinking cyclodextrin polymeric material by using cyclodextrin and diisocyanate in the presence of a composite catalyst is adopted, wherein the molar ratio of the cyclodextrin to the diisocyanate is controlled to be 1:(0.3-20); the composite catalyst is prepared by mixing an amine catalyst and a tin catalyst according to a certain ratio; and in the reaction process, the reaction temperature is controlled and the dropping speed of the diisocyanate is controlled to be 0.5 to 2 ml / min. The produced cyclodextrin polymeric material has a good effect of treating the aromatic hydrocarbon pollutants in the organic wastewater, so that the one-step removal rate of phenols in the wastewater can reach over 89 percent.

The invention relates to a cyclodextrin (CD) polymer / montmorillonite composite material and a preparation method thereof and belongs to the technical field of composite material preparation. According to the preparation method, a pre-synthesized polymer (P(CD-MA)) of maleic anhydride (MA) and CD is introduced into dopamine (DA) through amidation reaction, and then, the montmorillonite / cyclodextrin composite material is prepared through condensation between DA and hydroxyl groups of montmorillonite. The amount of introduced CD of the composite material can be controlled through changing the molecular weight of P(CD-MA), the content of DA and the content of montmorillonite. The method has the advantages that raw materials are easily obtained, the cost is low, the method is simple, and the amount of the introduced CD is large and is easy to control. According to the cyclodextrin polymer / montmorillonite composite material, metal ions and aromatic organic compounds in sewage can be simultaneously removed by using the metal ion exchange adsorbability of montmorillonite and the organic matter (especially aromatic organic matters) inclusion effect of cyclodextrin.

The invention relates to florfenicol water-soluble powder and a preparation method thereof. The water-soluble powder is prepared from the following raw materials in parts by weight: 5-20 parts of florfenicol, 25-95 parts of water-soluble cyclodextrin polymer (CDP) and 5-19 parts of hydroxypropyl beta-cyclodextrin. The powder can be completely dissolved into water, the room-temperature solubility can reach 33.5% and the water solution is completely clear. The room-temperature solubility can reach 33.5% (335,000ppm), and the effective content of the florfenicol can reach 15% (150,000ppm), and is about 3300 times of state-recommended clinical dosage and much higher than that of an existing florfenicol composition.

Provided are entrapped β-cyclodextrin polymers and a method of preparing the same. Particularly, entrapped β-cyclodextrin polymers are prepared by adding epichlorohydrin to β-cyclodextrin to prepare a polymer in a gel state, entrapping the polymer by entrapment of metal ions on the surface of the polymer and pulverizing the entrapped polymer to prepare powders. According to the entrapped β-cyclodextrin polymers, steroid hormones contained in a biological sample can be simply extracted without using an additional device required in conventional solid-phase extraction.

The invention relates to a preparation method for beta-cyclodextrin polymer-paclitaxel inclusion compound, and belongs to the technical fields of supermolecule inclusion and water-soluble drug preparing. According to the present invention, the beta-cyclodextrin and epichlorohydrin are subjected to a cross linking reaction under a strong alkaline condition to generate a beta-cyclodextrin polymer; then N,N-dimethylformamide is adopted as a reaction solvent, the beta-cyclodextrin polymer and the paclitaxel are subjected to a homogeneous supermolecule reaction to generate the beta-cyclodextrin polymer-paclitaxel inclusion compound; after completing the reaction, a precipitation agent is added to precipitate the solid; after carrying out sucking filtration, the resulting filter cake is washed with dehydrated alcohol, and is placed in an environment having a temperature of 30-50 DEG C to carry out vacuum drying to obtain the beta-cyclodextrin polymer-paclitaxel inclusion compound. According to the present invention, the operation is simple; the conditions are easy to be controlled; the product purity can be 95-98%; the product has excellent water solubility and stable structure; the structure and the pharmaceutical characteristic of the paclitaxel are not destroyed, such that the natural anti-cancer drug of the paclitaxel with poor water solubility is expected to be made into the oral drug or intravenous injection.