380 results about "Tartaric acid" patented technology

The invention provides an organic acid excited solid waste-based cementing material, and belongs to the technical field of solid waste utilization. The solid waste-based cementing material excited by the organic acid comprises 90-105 parts by mass of a silicon-aluminum solid waste base material, 7-12 parts by mass of sulfate and 15.3-19.8 parts by mass of a composite organic acid exciting agent, wherein the composite organic acid exciting agent comprises main acid and polyacrylic acid, and the mass of the polyacrylic acid is 10%-40% of the mass of the main acid; the main acid is one or a mixture of citric acid and tartaric acid. According to the organic acid excited solid waste-based cementing material, strong base is prevented from being adopted as an exciting agent, and the defects of a strong base excitation system are avoided.

The invention relates to an anti-aging capsule compounded by PQQ and mitochondrial nutrients, and discloses an anti-aging capsule which is prepared by synergistically compounding a plurality of mitochondrial nutrients according to a scientific proportion and supplementing high-purity raw materials and slow-release dosage forms to realize energy metabolism activation and anti-oxidation synergistic intervention. Therefore, the anti-aging capsule systematically delays aging through multi-target regulation and control of mitochondrial functions. The capsule is characterized by comprising the following components in parts by weight: 1-20 mg of pyrroloquinoline quinone disodium salt (PQQ), 20-100 mg of coenzyme Q10, 50-200 mg of L-carnitine tartrate, 10-100 mg of alpha-lipoic acid, 50-300 mg of nicotinamide mononucleotide (NMN) or nicotinamide nucleoside (NR), and 10-50 [mu] g of selenoprotein or organic selenium yeast, and a capsule carrier comprises 100 mg of gelatin or a plant-derived capsule shell, 180 mg of microcrystalline cellulose, 5 mg of magnesium stearate and 5 mg of silicon dioxide.

This invention discloses a method for dissolving NiCrPSi nickel alloy samples for ICP-OES detection, comprising the following steps: mixing the NiCrPSi nickel alloy sample to be tested with hydrochloric acid aqueous solution, concentrated nitric acid, and hydrofluoric acid aqueous solution, digesting at 120-140℃ for 1.5-2.5h, and then evaporating the solution to dryness at 220-260℃; then adding nitric acid aqueous solution and heating until the solid is completely dissolved, and then diluting with water to obtain the NiCrPSi nickel alloy test solution. The dissolution method of this invention can completely dissolve NiCrPSi nickel alloy powder without elemental loss, providing an accurate sample solution for ICP-OES detection; and it eliminates the need for specialized equipment such as microwave digesters or electrothermal digesters, as well as special reagents such as perchloric acid and tartaric acid, using only conventional acid reagents and general experimental equipment, thus reducing costs, simplifying operation, and enhancing versatility.

This invention belongs to the technical field of medicinal chemistry and provides a milrinone-tartaric acid cocrystal. Using Cu-Kα radiation, its X-ray diffraction pattern (expressed as 2θ) exhibits characteristic peaks at at least 10.0±0.2°, 13.2±0.2°, 20.4±0.2°, 24.7±0.2°, 26.2±0.2°, 26.7±0.2°, and 34.3±0.2°. The cocrystal of this invention has high solubility and good stability. Using this cocrystal to prepare formulations avoids the use of large amounts of excipients and auxiliaries in existing technologies, reducing both production costs and clinical safety risks. The preparation method of the milrinone-tartaric acid cocrystal provided by this invention is simple to operate, the crystallization process is easy to control, and it has good reproducibility.

A curcumin nanococrystal composition including curcumin, a coformer, and a stabilizer. The coformer may include at least one of 3,5-dinitrobenzoicacid, gentisic acid, phloroglucinol, 4,4-bipyridine, tartaric acid, citric acid, and gallic acid. The curcumin nanococrystal composition has a particle size less than 10 nm, and the curcumin has a water-solubility between 5 mg / ml and 20 mg / ml.

The invention discloses a method for retaining flavor of plum-leaf crab ice wine. The method comprises the following steps: 1, selecting red-pulp malus spectabilis fruits and eight-edge malus spectabilis fruits, washing, and draining with a vibrating screen until the surface moisture is less than or equal to 5%; 2, denucleating, taking pulp, pulping and sieving to obtain plum-leaf crab normal juice; 3, beta-glucosidase is added; 4, adding modified pectin microspheres, and carrying out three-stage cooling to obtain frozen plum-leaf crab normal juice; 5, slowly unfreezing, inoculating low-temperature-resistant saccharomyces cerevisiae liquid, and carrying out low-temperature segmented fermentation; 6, ageing; and 7, adding potassium tartrate, continuing for 2-3 months, filtering, and clarifying until the turbidity is less than or equal to 2NTU. The modified pectin microspheres with the adsorption-slow release function are added, terpene and ester flavor precursors in the plum-leaf crab are adsorbed in the fermentation period, the volatilization and hydrolysis rate of flavor substances in the fermentation process is reduced, especially the retention rate of plum-leaf crab characteristic fruity substances such as ethyl caprylate and ethyl caprate can be increased, and after being degraded, the modified pectin microspheres can be used for degrading the plum-leaf crab characteristic fruity substances. And the components are released back into the wine body.

Sterile filtered liquid lactase composition comprising a lactase, preferably a neutral or acidic lactase, an anion selected from malate, tartrate, citrate, gluconate and / or EDTA and a cation selected from sodium and potassium. Preferably, the composition further comprises a polyol. Addition of the said anions to lactase improves filterability by reducing pressure in a filtration system. Preferably the filtration forms part of an in-line filtration system in the production of a dairy product.

The invention relates to the technical field of zinc hydrometallurgy, and discloses an analysis method for measuring high cobalt content by an EDTA complexing back titration method, which is based on the following steps: oxidizing Co < 2 + > into Co < 3 + > by using potassium nitrite in an acetic acid medium to form cobalt potassium nitrite precipitate so as to realize separation of cobalt and interfering ions, dissolving the precipitate, complexing with excessive EDTA, and performing back titration by using a zinc standard solution. Xylenol orange is used as an indicator, and determination is completed at room temperature in a hexamethylenetetramine buffer system with the pH value being approximately equal to 5.8. Coexisting ion interference is effectively eliminated through tartaric acid, sodium fluoride, thiourea and other masking agents, the method has the advantages of being easy and convenient to operate, sensitive in end point, high in accuracy and low in cost, and the requirement for conventional analysis of high-cobalt materials can be met.

This application relates to the field of materials, and provides a method for preparing all-starch foamed tableware. By weight, the all-starch foamed tableware comprises the following components: 85-92 parts of composite modified starch, 23-38 parts of plant cellulose, 1-2 parts of foaming agent, 3.5-7 parts of nucleating agent, 1-1.5 parts of plasticizer, and 3-6 parts of crosslinking agent; wherein the foaming agent includes at least one of sodium bicarbonate, ammonium bicarbonate, and ammonium carbonate; the nucleating agent includes at least one of talc, calcium carbonate, montmorillonite, diatomaceous earth, straw powder, chitosan, and cyclodextrin; the plasticizer includes at least one of glycerol, sorbitol, ethanol, and water; and the crosslinking agent includes at least one of citric acid, malic acid, tartaric acid, maleic acid, succinic acid, and adipic acid. This application not only comprehensively improves the water resistance, heat resistance, mechanical strength, and cell uniformity of the all-starch foamed tableware, but also ensures that the product meets usage requirements.

The present application relates to the field of fluidized solidified soil, and discloses a kind of high-flow self-compacting fluidized solidified soil and its preparation process, including dry base engineering slag soil, mixing water, sodium hexametaphosphate, L (+) -tartaric acid, composite cementitious material, warm rubber dry powder and isoamyl alcohol polyoxyethylene ether polycarboxylic acid water reducing agent are made.The composite cementitious material is premixed with warm rubber dry powder;Slag soil is mixed with water and sodium hexametaphosphate to disperse internal mud group;Under continuous stirring, add tartaric acid aqueous solution, control the drop amount by using real-time monitoring of liquid phase pH value and closed-loop mechanism of tartaric acid consumption ratio, neutralize alkaline and inhibit early hydration heat release of cementitious material;Finally, add powder and water reducing agent for secondary stirring, and discharge and pour when liquid phase pH value jumps.The present application overcomes the hydration out of control caused by the fluctuation of different slag components through chemical synergy and dynamic feeding feedback of multiple components, avoids settlement stratification and bleeding, and ensures the stable development of high-flow state and later mechanical strength of slurry.

The invention discloses vinasse bread premixed flour and a preparation method thereof, and belongs to the technical field of bread premixed flour. The premixed flour comprises the following components in percentage by weight: 40%-60% of vinasse powder, 30%-40% of high gluten wheat flour, 5%-15% of rye flour, 3%-8% of vital gluten, 0.5%-1.5% of edible corn starch and 1%-2% of a bread improver. The bread improver is prepared by compounding mono-and diglycerides of fatty acids, diacetyl tartaric acid ester of mono-and diglycerides, a plurality of enzyme preparations and vitamin C. The preparation method comprises the steps of raw material pretreatment, mixing and the like. Compared with the prior art, by means of an optimized formula system, the technical problems that a dough system is degraded, the taste is hard, and aging is prone to occurring due to the fact that vinasse is added in a high proportion are successfully solved, and the finally-made bread is softer in taste and rich in elasticity, prolongs the shelf life and has high nutritive value and excellent eating quality.

This invention discloses a method for resolving isomers of methylfenacin ester, comprising: firstly, dissolving methylfenacin ester in a first solvent and adding L-tartaric acid, dissolving until clear; then adjusting the system temperature to 40℃-53℃ and adding L-tartaric acid seed crystals of the target isomer; subsequently, cooling the system to 20℃-30℃, filtering the precipitated product, and obtaining the L-tartaric acid seed crystals of the target isomer as the filter cake; dissociating the L-tartaric acid seed crystals of the target isomer using an alkaline resin, collecting the filtrate, and drying the filtrate to obtain the target isomer of methylfenacin ester. This invention achieves the resolution of isomers of methylfenacin ester by using L-tartaric acid, and through optimization of conditions, achieves a yield of not less than 74.1% and an ee of 91.1% for the target isomer of methylfenacin ester. The resolution method provided by this invention is simple to operate, easy to control, suitable for large-scale production, and meets industrial needs.

The disclosure relates to oral care compositions comprising guanidine in free or orally acceptable salt form, a cationic quaternary ammonium compound (e.g., a pyridinium compound) (e.g., cetyl pyridinium chloride (CPC)), a fluoride source, and optionally a zinc source (e.g., zinc lactate or zinc citrate and zinc oxide) as well as to methods of using and of making these compositions. 20 25 20 43 72 12 J un 2 02 5 2 0 2 5 2 0 4 3 7 2 1 2 J u n 2 0 2 5 A B S T R A C T T h e d i s c l o s u r e r e l a t e s t o o r a l c a r e c o m p o s i t i o n s c o m p r i s i n g g u a n i d i n e i n f r e e o r o r a l l y a c c e p t a b l e s a l t f o r m , a c a t i o n i c q u a t e r n a r y a m m o n i u m c o m p o u n d ( e . g . , a p y r i d i n i u m c o m p o u n d ) ( e . g . , c e t y l p y r i d i n i u m c h l o r i d e ( C P C ) ) , a f l u o r i d e s o u r c e , a n d o p t i o n a l l y a z i n c s o u r c e ( e . g . , z i n c l a c t a t e o r z i n c c i t r a t e a n d z i n c o x i d e ) a s w e l l a s t o m e t h o d s o f u s i n g a n d o f m a k i n g t h e s e c o m p o s i t i o n s . 2 0 2 5 2 0 4 3 7 2 1 2 J u n 2 0 2 5

This invention proposes a combined inhibitor for separating bastnaesite and monazite, along with its method and application. The raw materials for the combined inhibitor include small organic molecules and microbial polysaccharides; the small organic molecules include one or more of oxalic acid, malic acid, tartaric acid, lactic acid, succinic acid, and citric acid; the microbial polysaccharides include one or more of currant gum, guar gum, xanthan gum, and gellan gum. This invention achieves highly selective inhibition of monazite on the mineral surface through the synergistic adsorption and action of the inhibitor, with small organic molecules and microbial polysaccharides as the main components, thereby efficiently separating bastnaesite under mild flotation conditions. It offers advantages such as good selectivity, strong action, low reagent cost, and environmental friendliness.

The application relates to the technical field of molybdenum trioxide production, and particularly discloses a preparation method of high-purity molybdenum trioxide. The method comprises the following steps: preparing a complexing impurity removing agent by taking diatomite, citric acid, ethylenediaminetetraacetic acid disodium and tartaric acid as raw materials; dissolving industrial ammonium dimolybdate to obtain an ammonium molybdate solution, adding the impurity removing agent into the ammonium molybdate solution, complexing impurities under an acidic condition, and deeply removing the impurities through flocculation and precision filtration; adjusting the alkalinity of the filtrate, and cooling and crystallizing the filtrate to obtain high-purity ammonium molybdate; and finally performing program-controlled temperature calcination in an atmosphere with a specific oxygen content by using a quartz boat coated with a composite coating on the inner wall, so as to obtain high-purity molybdenum trioxide. The application combines multi-stage purification with an accurate calcination process, can efficiently remove impurities in raw materials, and has stable process flow; the obtained molybdenum trioxide product has high purity, good crystal morphology, good process stability and good industrialization prospect.

The invention relates to the technical field of apple production place detection, in particular to a red Fuji apple production place discrimination method based on organic component analysis, which comprises the following steps: S1, constructing a linear discrimination function of organic components such as oxalic acid, succinic acid, tartaric acid, citric acid, malic acid, phlorizin, chlorogenic acid and rutin; s2, obtaining the contents of oxalic acid, succinic acid, tartaric acid, citric acid, malic acid, phlorizin, chlorogenic acid and rutin in the apple sample to be detected; s3, inputting the contents of oxalic acid, succinic acid, tartaric acid, citric acid, malic acid, phlorizin, chlorogenic acid and rutin in the obtained apple sample to be detected into the linear discrimination function, and taking a group of maximum discrimination function calculation values as a production area detection result. According to the method, the production places of red Fuji apples in five production areas can be discriminated to a certain extent through linear discrimination established on the basis of eight organic components, the classification accuracy rate reaches 95.2%, and technical support is provided for the production place traceability of the Jinning apples and the quality control of the apples.

The invention discloses a preparation method of a nitrogen-sulfur co-doped lignin-based hierarchical porous carbon material and supercapacitor energy storage application, and belongs to the technical field of preparation methods and application of porous carbon materials, and the preparation method comprises the following steps: (1) dropwise adding an ammonium sulfate solution into sulfate pulping black liquor, and adjusting the pH value, after standing reaction, drying to obtain ammonium sulfate precipitated lignin; (2) uniformly mixing lignin with potassium tartrate and potassium nitrate, drying and grinding to obtain a mixture; and (3) pyrolyzing the mixture in an inert atmosphere, washing the carbonized product with dilute acid, filtering, and drying to obtain the porous carbon material. Potassium tartrate promotes formation of graded pores through the mild pore-forming effect, and the foaming effect of potassium nitrate can inhibit formation of coal tar and excessive carbon skeleton etching in the pyrolysis process. The supercapacitor electrode material prepared from the porous carbon has high specific capacitance, excellent cycling stability and high energy density.

The utility model discloses a cold stable filtering equipment for brewing, include: filter jar, the top end of filter jar is used for the hole of external connection pipe, the bottom of hole is fixedly connected with the telescopic pipe for sealing shell, one side of filter jar is provided with the discharge pipe, and one end of discharge pipe extends to the inside of telescopic pipe for sealing shell through the hole, and one end of discharge pipe located telescopic pipe for sealing shell is fixedly connected with the stretch extension pipe. The utility model discloses through drawing out height control mechanism, utilize control electric push rod to push the chain wheel upward, and the chain wheel moves upward and rolls simultaneously, and make its chain located one end of telescopic pipe for sealing shell upward and pull telescopic pipe for sealing shell and stretch extension pipe synchronous rising simultaneously, promote telescopic pipe for sealing shell and stretch extension pipe rising and folding simultaneously, be favorable to according to the wine body flow rate adjustment draw out height, guarantee after the wine liquid of filtering for many times can have enough time to carry out the reprecipitation time again, guarantee the wine body tartrate can remove completely.

New derivatives of 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl) phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo [3,4c] pyridine-3-carboxamide (Apixaban) able to increase its water solubility. These derivatives are cocrystals derivatives ofApixaban of different acids, from which the most outstanding are the following: Apixaban Malonic Acid derivative, Apixaban-a-Ketoglutaric Acid derivative, Apixaban-Gallic Acid derivative, Apixaban-Maleic Acid derivative, Apixaban-L-Tartaric Acid derivative, and Apixaban Citric Acid derivative.

The invention discloses clobetasol propionate liniment and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The clobetasol propionate liniment provided by the invention consists of clobetasol propionate and dipotassium glycyrrhizinate which serve as effective components, absolute ethyl alcohol serving as a cosolvent and a novel eutectic solvent aqueous solution. The eutectic solvent aqueous solution is prepared by heating a citric acid aqueous solution and a tartaric acid aqueous solution under specific conditions. The invention also provides a method for preparing the clobetasol propionate liniment. A eutectic solvent formed by citric acid and tartaric acid is used as a main solvent, so that the use amount of absolute ethyl alcohol is reduced, and the use irritation is reduced. According to the liniment, the solubility and stability of clobetasol propionate which is extremely difficult to dissolve in water in a liniment system are improved, meanwhile, the formula system is mild, skin irritation caused by ethyl alcohol is reduced, and the liniment has good safety and application prospects.

The application discloses an anti-caking salt product and a preparation method thereof. The anti-caking salt product comprises raw salt and an anti-caking agent, the anti-caking agent is food-grade ferric tartrate, and the addition amount of the anti-caking agent is 0.05-0.106 g / kg of the salt. The core of the anti-caking method of the salt lies in that the food-grade ferric tartrate is used as the main anti-caking agent, the addition amount is 0.05-0.106 g / kg of the salt, the salt is dried at 100 DEG C for 4 hours, then the anti-caking agent is added, and the water vapor transmission rate is less than or equal to 0.5 g / m 2 24h of high-barrier material packaging, while 6 g of quicklime or 2 g of calcium chloride desiccant is added in every 200 g of the salt. The application also controls the Mg 2+ content in the salt to be less than or equal to 0.02%, the KCl content to be less than or equal to 10%, and the particle size to be in the range of 0.45-0.6 mm, so that the salt caking is synergistically inhibited from multiple dimensions. The method has extremely significant anti-caking effect (the caking rate is only 8.7% after 15 days of open storage), is safe and economical, and has a simple process, and can effectively replace or reduce the use of potassium ferrocyanide, and is suitable for large-scale industrial production.

The invention relates to the field of material surface treatment, in particular to a chemical polishing solution and a polishing method. The chemical polishing solution is suitable for the ferro-nickel alloy with the nickel content of 20-60% and the doped element content of less than 1%, and comprises an accelerant, a first acidic agent, a second acidic agent, a corrosion inhibitor, a brightener and a solvent. The first acidic agent comprises at least one of sulfuric acid, hydrochloric acid, nitric acid, phosphoric acid and hydrofluoric acid, and the content is greater than or equal to 5%. The second acidic agent comprises at least one of ammonium bifluoride, ammonium fluoride, formic acid, benzoic acid, acetic acid, propionic acid, butyric acid, lactic acid, oxalic acid, malonic acid, tartaric acid, malic acid and citric acid, and the content of the second acidic agent is 1%-50%. The total content of the first acidic agent and the second acidic agent is 6-60%. The accelerant is used for oxidizing metal nickel and metal iron, and the content of the accelerant is 0.01%-5%. And the content of the corrosion inhibitor is 0.1-5%. By combining the accelerant, the first acid agent, the second acid agent and the corrosion inhibitor, the dissolving speed of the nickel phase and the iron phase is balanced, the surface flatness is improved through the brightening agent, and the polishing effect is improved.

The present application relates to the technical field of external use patch, disclose a kind of neck shoulder waist leg pain health care patch and its preparation method, the health care patch includes backing layer, ointment layer and anti-adhesion release layer;Ointment layer raw material includes: traditional Chinese medicine extract flow leaching paste, L- (+) -tartaric acid, PVP K30, PEG-400, ternary eutectic solvent, polyacrylate pressure sensitive adhesive matrix and ultrafine medicinal powder.Preparation, after flow leaching paste, tartaric acid etc. are mixed, gel precursor is formed by vacuum dewatering and dealcoholization, swelling is added again with eutectic solvent, and then mixed with pressure sensitive adhesive matrix and medicinal powder high shear, finally coating solidification.The present application constructs physical crosslinking gel network in colloid interior and promotes effective component acid-base salt formation, effectively avoids polar component crystallization precipitation, reduces the skin irritation caused by drug burst release, simultaneously improves the cohesion of ointment, realizes long-acting smooth drug release.

This invention relates to an extraction method for improving the bioavailability of tartrate tylosin. The method includes subjecting tartrate fermentation broth to a single acid-dissolution and alkali-precipitation treatment, followed by static crystallization to obtain crude tartrate. This crude tartrate is then subjected to extraction and back-extraction steps, followed by decolorization and ultrafiltration to obtain refined tartrate. Finally, it is spray-dried to obtain tartrate tylosin. This invention optimizes the extraction process of tartrate tylosin by combining a single acid-dissolution and alkali-precipitation crystallization purification process with extraction and back-extraction processes, effectively improving the bioavailability of tartrate tylosin.

This invention provides a medical cold compress hydrogel bandage, relating to the biomedical field. It is a bandage roll structure, primarily comprising a bandage fabric body capable of being rolled into a roll. In its unfolded state, the bandage fabric body has a gel layer and a connector fixedly disposed on one surface, with the gel layer and connector positioned near the two ends of the bandage. The gel layer is used for direct contact with the skin during bandaging, and the connector is used to fix the bandage ends to the fabric surface of the bandage fabric body after bandaging. When the bandage fabric body is rolled into a roll, the gel layer end is located at the outer end of the roll, and the connector is located at the core of the roll. The gel layer includes component A, component B, and purified water. Component A mainly includes glycerin, sodium polyacrylate, and a self-made composite crosslinking agent, while component B mainly includes kaolin and tartaric acid. This invention ensures both the ease of use of the bandage roll and its ability to be easily unrolled and used within a relatively long shelf life.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a synthesis method of tartaric acid, according to the method, maleic anhydride is taken as a raw material, a phosphotungstic acid modified gel material is taken as the phosphotungstic acid modified gel material, hydrogen peroxide is adopted for epoxidation, then ring opening is performed under acid to prepare tartaric acid, the tartaric acid prepared by the method is high in yield and purity, and the tartaric acid can be recycled. The method can be directly applied to food and medicine fields.

According to the fermented feed capable of improving the antioxidant capacity of the animal body and the preparation method of the fermented feed, cerium-zirconium-iron composite oxide ceramic microspheres are prepared and applied to the fermentation process, and in solid fermentation, the microspheres, raw materials pretreated by diacetyl tartaric acid monoglyceride and high-activity complex microbial inoculants have a synergistic effect, so that the antioxidant capacity of the animal body is improved. By quenching active oxygen, the fermentation microenvironment is remarkably optimized, metabolism of functional microorganisms and accumulation of products are promoted, the microspheres can be recycled after fermentation, a functional feed product with the antioxidant activity remarkably improved is finally obtained, and unification of material circulation, process synergy and product increment is achieved.

The invention relates to the technical field of leavening agents, and discloses a food composite leavening agent, which comprises the following components by mass: 25-30 parts of ammonium bicarbonate; 15 to 23 parts of microencapsulated ammonium citrate; 8 to 16 parts of sodium pyrophosphate; 5 to 9.5 parts of L-potassium hydrogen tartrate; 13 to 17 parts of trehalose; 0.5 to 1.3 parts of surface modified nano silicon dioxide; and 10 to 17 parts of hydroxypropylated cassava starch. The microencapsulated ammonium citrate is formed by coating beta-cyclodextrin, and the thickness of an embedding layer is 16-20 [mu] m. The multi-layer microcapsule structure is constructed by carrying out gradient embedding on ammonium citrate through beta-cyclodextrin, so that staged release of gas production substances is realized. According to the structure, different temperature intervals are accurately matched in the baking process, it is guaranteed that the gas production rate is synchronous with the dough expansion requirement, and the problem of excessive expansion or insufficient gas production caused by concentrated release in the traditional technology is solved.

A method for resolving a phenylalanine derivative of formula (I), and an intermediate. The method comprises: a resolving step comprising using a resolving reagent to react with the phenylalanine derivative represented by formula (I) in a reaction solvent to obtain a resolved intermediate, wherein the resolving reagent is selected from N-acetyl-D-phenylalanine and / or (2R,3R)-(−)-dibenzoyl-L-tartaric acid, and the reaction solvent is selected from 90-99% aqueous ethanol, absolute ethyl alcohol, or acetone. The method uses a chiral reagent to perform salt formation and racemate resolution, and has the advantages of being easy to operate, requiring no special production devices, and being easy to scale up production.