337 results about "Borneol" patented technology

This invention relates to the field of traditional Chinese medicine (TCM) technology, specifically to a nasal massage oil, its preparation method, and its application. The nasal massage oil is prepared from the following TCM raw materials in the indicated weight proportions: 4-6 parts of roasted Xanthium sibiricum, 1.5-3.5 parts of Magnolia biondii, 1.5-3.5 parts of Angelica dahurica, 0.3-0.7 parts of Mentha haplocalyx, 0.8-1.2 parts of Borneol, 2-4 parts of Sinapis alba, 1-3 parts of Artemisia argyi, 1-3 parts of Carthamus tinctorius, 1-3 parts of Cinnamomum cassia, 2-4 parts of Pueraria lobata, and 80-120 parts of sesame oil as a base. This application, through scientific formulation and reasonable proportioning, effectively solves the technical problem that existing nasal massage mediums only provide lubrication and lack targeted TCM conditioning effects, failing to achieve synergistic effects between massage and medication. It achieves an integrated effect of "massage lubrication - drug penetration - TCM conditioning."

The present application relates to a pharmaceutical composition comprising an NRF2 agonist and borneol, both of which synergize in a specific molar ratio range, enhance the overall anti-inflammatory and antioxidant biological activity of the drug, improve the oral bioavailability and target tissue distribution of the drug, inhibit the off-target side effects of the NRF2 agonist, and significantly improve the effectiveness and safety of the drug.

The invention discloses a compound scar ointment and a preparation method thereof, the ointment is prepared by decocting and concentrating Chinese herbal medicines such as salvia miltiorrhiza, cassia twig, radix paeoniae alba, rheum officinale, radix sophorae flavescentis, pepper, folium artemisiae argyi, lycopodium clavatum, garden balsam stem, pawpaw and borneol as raw materials and adding a matrix. The ointment has the effects of promoting blood circulation to remove blood stasis, relaxing tendons, activating collaterals, clearing heat and eliminating dampness, can effectively inhibit scar hyperplasia and promote scar softening and dissipation, and is suitable for treating various scars and acne marks. The ointment is simple in preparation process, green and environment-friendly, safe and non-irritant to use, good in clinical effect and wide in application prospect.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a medicine patch needle for preventing and treating allergic rhinitis and a preparation method and application thereof. The medicine patch needle mainly comprises a traditional Chinese medicine composition and a medicine patch thumbtack needle, and the traditional Chinese medicine composition is prepared from, by weight, 30-60 parts of radix astragali, 15-30 parts of radix angelicae sinensis, 10-25 parts of radix saposhnikoviae, 10-30 parts of rhizoma atractylodis, 10-30 parts of rhizoma acori graminei, 5-15 parts of herba asari, 10-30 parts of rhizoma chuanxiong, 10-20 parts of radix angelicae and 1-5 parts of borneol. The medicine needle patch can be used for preventing and treating allergic rhinitis, mild and lasting acupuncture stimulation is achieved on the skin part of the acupoint, the medicine can rapidly enter the acupoint along with the needle hole, in other words, the acupoint achieves the effects of harmonizing qi and blood, relieving stuffy nose and removing pathogenic qi under the dual action of the acupuncture stimulation and the medicine, and the medicine needle patch has the remarkable preventing and treating effect on the allergic rhinitis.

The invention relates to a pharmaceutical composition, which is prepared from adapalene, benzoyl peroxide, a traditional Chinese medicine extract, an acrylamide and acryloyl dimethyl sodium taurate copolymer, a mixture of isohexadecane and polysorbate 80, docusate sodium, EDTA (Ethylene Diamine Tetraacetic Acid) disodium, glycerol, poloxamer 124, propylene glycol and water, the traditional Chinese medicine extract comprises moutan bark, salvia miltiorrhiza, radix rehmanniae recen, radix sophorae flavescentis, coptis chinensis, rheum officinale, scutellaria baicalensis, menthol and borneol. According to the pharmaceutical composition disclosed by the invention, the synergistic antibacterial and anti-keratosis curative effects of adapalene and benzoyl peroxide can be maintained, and meanwhile, the occurrence rate of local skin dryness, erythema, desquamation, burning heat sensation and contact dermatitis can be remarkably reduced.

The invention provides a traditional Chinese medicine composition for treating cerebrovascular diseases and a preparation method and application thereof, and belongs to the technical field of biological medicine. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 8 to 12 parts of rhizoma chuanxiong, 12 to 17 parts of radix paeoniae rubra, 13 to 18 parts of radix salviae miltiorrhizae, 8 to 12 parts of radix polygalae, 10 to 15 parts of rhizoma acori graminei, 27 to 32 parts of radix astragali seu hedysari, 0.3 to 0.7 part of borneol, 0.1 to 0.2 part of musk, 12 to 18 parts of radix angelicae sinensis, 6 to 12 parts of flos carthami, 7 to 12 parts of semen persicae and 5 to 7 parts of radix glycyrrhizae preparata. The traditional Chinese medicine composition disclosed by the invention has the curative effects of tonifying qi and activating blood, dispersing blood stasis and dredging collaterals, and restoring consciousness and inducing resuscitation. The traditional Chinese medicine composition can be combined with a leg electrical stimulation system to efficiently treat cerebral apoplexy hemiplegia and effectively treat vascular dementia, and has an obvious treatment effect on cerebrovascular diseases. The preparation method of the traditional Chinese medicine composition is simple, convenient and rapid, and is suitable for industrial production.

The invention relates to the technical field of health-care external application agents, in particular to Qianzhou treatment Shukangtang tendon-relaxing and bone-penetrating health-care paste which is formed by combining subpackaged powder and subpackaged liquid. The powder comprises a mixture of the following Chinese herbal medicines according to a mass ratio: safflower, homalomena occulta, radix angelicae pubescentis, verbena, dragon's blood and centipede, and each component can be adjusted in a range of + / -20% as required; the liquid is based on a soaking decoction obtained by soaking and decocting safflower, radix angelicae, caulis spatholobi and mint as main medicinal materials in water, filtering and cooling, the content of ethanol in the liquid is 2-12%, the content of glycerol in the liquid is 1-6%, and the dosage of borneol is 0.1-2.0 g; the powder is a Chinese herbal medicine powder mixture which is dried, crushed and sieved. According to the invention, powder and liquid are subpackaged, and detectable indexes such as granularity, moisture and auxiliary material ratio and the like are determined, so that the standardization and repeatability of the formula and the process are realized, the stability and the transdermal permeation efficiency of the product are obviously improved, and the curative effect similar to that of a store can be obtained after on-site / family rapid blending.

The present application relates to the technical field of wound repair, and provides a traditional Chinese medicine composition for promoting wound healing and a preparation method thereof.The traditional Chinese medicine composition comprises a first traditional Chinese medicine composition and a second traditional Chinese medicine composition which are applied to the acute phase and the repair proliferation phase.The former comprises naked flower purple perilla extract, nectarine leaf extract, purple perilla extract, dragon's blood micro powder, spironast extract, centella asiatica volatile oil, rhubarb extract, borneol, mussel mucin, medicinal glycerol and purified water.The latter comprises red algae extract, nectarine leaf extract, radix astragali extract, panax notoginseng total saponins, aloe extract, dendrobium officinale extract, sea buckthorn extract, pinctada martensii purified peptide, snail glycosaminoglycan, medicinal glycerol and purified water.The composition can play the roles of antibiosis, anti-inflammation, hemostasis, analgesia and astringency in the acute phase, and can promote angiogenesis, collagen synthesis and epithelial regeneration in the repair proliferation phase, so that the wound is rapidly repaired and healed.

The invention provides pain-relieving and stasis-dissipating powder for treating soft tissue and gout, and relates to the technical field of traditional Chinese medicines. The pain-relieving and stasis-dissipating powder for treating soft tissue and gout is prepared from cortex phellodendri, fructus gardeniae, frankincense, myrrh, radix et rhizoma rhei, radix angelicae sinensis, radix angelicae and borneol. The pain-relieving and blood stasis-dissipating powder has the effects of promoting blood circulation to remove blood stasis, relieving swelling and pain, clearing heat, eliminating dampness, removing blood stasis and promoting tissue regeneration, and has a remarkable curative effect on early fracture, soft tissue injury, gout, synovitis and the like.

The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by mass: 5 to 10 parts of cortex phellodendri, 5 to 10 parts of radix scutellariae, 5 to 10 parts of radix notoginseng, 5 to 10 parts of melastoma dodecandrum lour, 8 to 15 parts of herba lycopi, 8 to 15 parts of rhizoma alismatis, 8 to 15 parts of herba lycopodii, 12 to 18 parts of semen coicis, 1 to 3 parts of borneol, 135 to 150 parts of beewax and 390 to 400 parts of sesame oil. The She nationality characteristic medicinal material melastoma dodecandrum serves as a core component, the Qi and blood theory of traditional Chinese medicine is combined, multiple blood circulation promoting and stasis removing medicinal materials are combined, the comprehensive treatment effects of promoting blood circulation to remove swelling, regulating Qi to dissipate blood stasis and stopping bleeding and relieving pain are jointly achieved, the red, swollen and heat pain symptoms in the acute stage of fracture and sprain can be remarkably relieved, and the curative effect is good. The traditional Chinese medicine composition has the action trend of reducing local exudation and preventing swelling persistence, and has a practical clinical external treatment value for promoting early functional recovery of wounds.

The present application relates to a kind of hyperbranched polymer, nano preparation and its preparation method and application, belong to functional medical material and nanotechnology field.The hyperbranched polymer of the present application can be broken in ROS environment Release dihydrolipoic acid, play the role of antioxidant, be reduced to lipoic acid in vivo, and then play its role as coenzyme, participate in mitochondrial tricarboxylic acid cycle, restore mitochondrial function, thereby play the role of antioxidant and play the role of treating ischemic stroke.The nano preparation provided by the present application can be quickly distributed to brain in a short time, temporarily increase the paracellular permeability of BBB by inhibiting the expression of multi-drug resistance protein P-gp and ATP-dependent drug efflux protein on BBB, and the process of opening BBB by borneol is physiological and reversible, without destroying the structural integrity of blood-brain barrier.

This invention provides a medicinal ointment for treating rhinitis based on a traditional Chinese medicine compound and its preparation method, relating to the field of traditional Chinese medicine technology. The medicinal ointment for treating rhinitis based on a traditional Chinese medicine compound comprises the following components in parts by weight: Bupleurum chinense 2-10 parts, Dictamnus dasycarpus root bark 3-7 parts, Magnolia biondii flower 8-12 parts, Xanthium sibiricum fruit 4-10 parts, Centipeda minima 2-6 parts, Liquidambar formosana fruit 6-10 parts, Chrysanthemum indicum flower 6-10 parts, Angelica dahurica root 6-12 parts, Houttuynia cordata flower 8-12 parts, Borneol 1-3 parts, Menthol 1-3 parts, Ligusticum chuanxiong rhizome 5-13 parts, Scutellaria baicalensis root 8-12 parts. The ingredients are: 5-11 parts licorice root, 9-10 parts calamus, 1-5 parts Fritillaria thunbergii, 2-6 parts Gleditsia sinensis thorns, 6-10 parts Saposhnikovia divaricata, 8-12 parts Cynanchum paniculatum, 3-9 parts Kochia scoparia, 1-2 parts artificial musk, 5-8 parts ginger, 3-4 parts myrrh, 4-6 parts Schisandra chinensis, 1-3 parts petrolatum, 1-3 parts beeswax, and 2-3 parts coconut oil. In this invention, myrrh reduces acute inflammatory reactions of the nasal mucosa through its anti-inflammatory effect, while Schisandra chinensis reduces secretions through its astringent effect. The combination of the two can effectively relieve nasal congestion and runny nose symptoms.

This invention provides a topical medicine composition for clearing heat, reducing swelling, and resolving blood stasis in the acute phase, along with its application and preparation method, belonging to the field of traditional Chinese medicine formulation technology. This topical medicine composition for clearing heat, reducing swelling, and resolving blood stasis in the acute phase consists of the following raw material components in parts by weight: 5-8 parts raw Phellodendron bark, 2-5 parts borneol, 8-12 parts red peony root, 4-8 parts Panax notoginseng tablets, 4-6 parts stir-fried ground beetle, 2-4 parts prepared myrrh, 2-4 parts prepared frankincense, 5-8 parts prepared Arisaema, 8-12 parts Liquidambar formosana, 8-12 parts Angelica dahurica, 8-12 parts peppermint, and 8-12 parts Trichosanthes kirilowii. This topical medicine composition for clearing heat, reducing swelling, and resolving blood stasis in the acute phase selects traditional Chinese medicinal materials with relatively weak blood-activating effects, which can avoid the risk of increased bleeding and swelling during acute use, achieving safe and effective early intervention for ankle or other injuries in the acute phase, thereby shortening the patient's recovery time.

The invention relates to the technical field of traditional Chinese pharmacology, and particularly discloses an external liquid containing lime and alum for astringing sores and a preparation method of the external liquid. The external liquid containing lime and alum for healing sores is prepared from the following raw materials: lime, alum, water, a thickening agent, a cortex phellodendri extract, carbonized sanguisorba root powder, borneol and a pH regulator. The preparation method comprises the following steps: S1, preparing lime milk; s2, preparing an alum solution; s3, mixing reaction; s4, performing curing treatment; s5, blending; s6, refining: filtering the mixture obtained in S5, adding borneol and ethylparaben into the filtrate before filtering, and uniformly stirring to obtain the external liquid for healing sore. The external liquid containing lime and alum for healing sores can be used for treating various skin injuries such as skin ulcers, wounds, burns, eczema and postoperative wounds, and has the advantages of efficient astringency and hemostasis, antisepsis and anti-inflammation, promotion of wound healing, good system stability, comfort in use and high safety.

The present application belongs to the technical field of traditional Chinese medicine composition, and relates to a traditional Chinese medicine transdermal external preparation for treating vulvar hypopigmentation disease. The preparation is a paste prepared by mixing traditional Chinese medicine powder and horse oil. The traditional Chinese medicine powder is composed of the following raw materials by weight: Xuchangqing 10-12, Pugongying 10-15, Difusiduo 12-15, Tuzifuding 12-15, Baiji 10-15, Huzhang 9-12, Quansie 6-10, Diyu 10-12, Xuezhi 10-12, Danggui 6-10, Rushang 6-10, Miedu 6-10, Bingpian 1-3. The traditional Chinese medicine transdermal external preparation has definite and significant effects on vulvar hypopigmentation disease, especially in relieving intractable pruritus, promoting pigment recovery and improving skin sclerosis / atrophy. The traditional Chinese medicine transdermal external preparation has high safety, few adverse reactions and low recurrence rate.

This invention provides a traditional Chinese medicine composition and its application in the preparation of a topical herbal eye patch for treating thyroid eye diseases, belonging to the field of biomedical technology. The herbal composition consists of *Gynostemma pentaphyllum*, peppermint, *Platycladus orientalis* leaves, borneol, cicada slough, *Astragalus membranaceus*, *Selaginella tamariscina*, *Pteris vittata*, *Scutellaria baicalensis*, apricot leaf, and *Ipomoea aquatica*. Using this herbal composition as raw material, a topical herbal eye patch is prepared. This patch acts directly on acupoints and skin around the eyes, allowing the medicinal properties to penetrate the skin and reach the eye system, achieving the effects of promoting blood circulation, clearing heat and detoxifying, invigorating qi and unblocking meridians, reducing swelling and improving vision. It is suitable for the treatment of thyroid-related eye diseases. This invention's topical herbal eye patch can effectively improve clinical symptoms such as exophthalmos and eye inflammation in patients with thyroid eye diseases, positively impacting their quality of life and effectively improving the clinical treatment efficacy of this disease. The topical herbal eye patch provided by this invention can be further promoted and applied in the clinical treatment of thyroid eye diseases.

The invention discloses swelling and pain relieving ointment for pyretic arthralgia and a preparation method thereof. The swelling and pain relieving ointment is prepared from the following components: 30 to 50 parts of radix et rhizoma rhei, 30 to 50 parts of radix scutellariae, 30 to 50 parts of cortex phellodendri, 30 to 50 parts of radix angelicae, 30 to 50 parts of rhizoma arisaematis, 30 to 50 parts of radix trichosanthis, 10 to 20 parts of rhizoma atractylodis, 30 to 50 parts of rhizoma curcumae longae, 20 to 40 parts of myrrh, 10 to 20 parts of mirabilite, 10 to 20 parts of alum and 5 to 15 parts of borneol. The swelling and pain relieving ointment for pyretic arthralgia has remarkable effects of diminishing inflammation, relieving swelling and relieving pain. Clinical application verifies that the traditional Chinese medicine composition can quickly relieve aseptic inflammation and red, swollen and heat pain symptoms of joints and local soft tissues. The external use mode is convenient and practical, and patients can operate by themselves without complex procedures. Meanwhile, the plaster adopts a pure traditional Chinese medicine formula, is nontoxic and free of side effects, and avoids irritation of oral medicines to gastrointestinal tracts. According to the traditional Chinese medicine composition, cold medicines are used as main medicines, meanwhile, warm medicines such as rhizoma arisaematis and radix angelicae are combined, and cold and warm medicines are used together, so that the main effects of clearing heat and eliminating dampness are guaranteed, cold congealing and dampness obstructing caused by excessive cold and cool are prevented, and the ingenious idea of'counter-assistant 'of traditional Chinese medicine is embodied.

The application provides a synthesis method of 1-substituted phenanthrene compounds, which comprises the following steps: mixing ortho-substituted aryl diazonium salt with KI, adding a palladium acetate catalyst, adding norbornadiene, adding a base, adding an organic phosphine ligand, adding 2-halobenzoic acid, heating to 80-150 DEG C in an aprotic solvent under a nitrogen atmosphere, and reacting for 2-10 hours to obtain the 1-substituted phenanthrene compounds. The method uses cheap and easily obtained ortho-substituted aryl diazonium salt instead of expensive aryl iodide to prepare 1-substituted phenanthrene compounds, and has the characteristics of easy raw material, mild conditions and simple operation, and is a simple synthesis method of 1-substituted phenanthrene compounds.

The application provides a preparation process of Miaogukanghuoluo oil and belongs to the technical field of medicinal oil production. The process comprises the following steps: S1, preparing raw materials with a certain weight ratio: Sanqi 3.5%-4%, Chuanqiong 4.5%-5%, wintergreen oil 5%-6%, menthol 7.5%-8%; S2, after Sanqi and Chuanqiong are processed and qualified, they are poured into a feeding pipe together with menthol, camphor and borneol, a rotating assembly is used to crush and pulverize the medicinal raw materials, and the crushed medicinal powder is fully mixed; S3, a user pours wintergreen oil, pine oil, clove oil and Shancang oil into the bottom of the installation shell through an oil inlet pipe in proportion, so that the medicinal oil mixture is prevented from adhering to the surface of the stirring assembly and causing medicinal waste; S4, the fully mixed medicinal oil mixture is placed and bottled to obtain Miaogukanghuoluo oil. The rotating assembly is arranged to prevent solid particles from affecting the overall medicinal effect of the huoluo oil, and the stirring assembly is arranged to further improve the mixing effect of the medicinal powder and medicinal oil.

Provided are a Cinnamomum burmannii monoterpene synthase CbTPS1, an amino acid sequence thereof, a nucleic acid molecule encoding the protein, an use thereof in preparing the monoterpene synthase, and a method for preparing dextrorotatory borneol by using the Cinnamomum burmannii monoterpene synthase CbTPS1.

The application discloses a traditional Chinese medicine body milk and a preparation method thereof. The traditional Chinese medicine body milk comprises the following components by weight: 5-15 parts of traditional Chinese medicine active ingredients derived from an ancient prescription of Danggui Yinzi, 1-3 parts of vitamin E, 0.5-2 parts of ceramide NP with a purity of greater than or equal to 95%, and 0.1-0.5 parts of natural borneol with a purity of greater than or equal to 99%, and the rest is an oil phase matrix, an aqueous phase matrix and an emulsifier. The traditional Chinese medicine active ingredients comprise angelica extract, astragalus polysaccharide, sophoramine and glycyrrhizic flavone, and are obtained by a low-temperature warm extract process at 40-45 DEG C. The preparation method comprises the following steps: raw material pretreatment, warm extract extraction, filtration and purification, precise compounding and fusion, emulsification and molding, and cooling and filling. The product has the advantages that skin irritation is less than 0.3, 24-hour moisturizing power is greater than or equal to 78%, the retention rate of herbal active ingredients is greater than or equal to 83.2%, and absorption is achieved within 5 minutes after smearing, and is specially used for improving the problems of dry skin, itching and difficult healing of wounds caused by blood deficiency and dryness caused by old age and chronic diseases.

The invention provides a mild refreshing borneol essential oil compound as well as a preparation method and application thereof. The borneol essential oil compound is prepared from the following components in parts by weight: 1 to 50 parts of borneol, 0.1 to 50 parts of menthol, 1 to 10 parts of natural camphor, 0.1 to 0.5 part of herba dendrobii essential oil, 35 to 70 parts of carrier oil, 0.2 to 1 part of vitamin E, 1 to 3 parts of eudesmol, 0.2 to 1 part of limonene and 0.5 to 5 parts of cinnamomum camphora essential oil clathrate compound. The borneol essential oil compound prepared by the invention has the advantages of better stability, high essential oil retention rate, freshness and durability, mild components without skin irritation, and refreshing effect, and can be applied to preparation of products such as snorting essential oil, roll-on essential oil or vehicle-mounted fragrance and the like.

The invention provides an antibacterial and anti-inflammatory traditional Chinese medicine compound preparation and a preparation method thereof. The compound preparation is prepared from the following raw materials in parts by weight: 10 to 30 parts of fructus forsythiae, 10 to 25 parts of flos chrysanthemi, 15 to 40 parts of rhizoma imperatae, 5 to 10 parts of herba menthae, 0.5 to 3 parts of borneol and 0.1 to 3 parts of camphor. The main innovation point of the formula is that triple mechanisms of clearing away heat and toxic materials, repairing mucous membranes and rapidly relieving pain are innovatively fused; instantaneous mucous membrane permeation is realized through volatile components (borneol, mint and camphor), and itching and pain are quickly relieved; forsythia suspense-chrysanthemum-couch grass root synergistically inhibit release of inflammatory factors and radically diminish swelling, and the specific functions are as follows: forsythia suspense has antibacterial and antiviral effects and inhibits streptococcus in throat; chrysanthemum has the effects of clearing liver fire, relieving heat toxin and eliminating mucosal hyperemia; the couch grass root can promote salivation, moisten dryness and repair damaged mucosa; mint is capable of quickly relieving itching and promoting transmembrane absorption of the medicine; borneol is used for instantly cooling and easing pain and opening a cell channel; and camphor and local anesthesia enhance the pain relieving time efficiency.

The invention relates to the technical field of biological medicines, and particularly discloses a chronic wound healing promoting traditional Chinese medicine compound loaded wound and ulcer paste, which comprises a hydrogel matrix and a traditional Chinese medicine compound, and the traditional Chinese medicine compound is prepared from the following raw materials in parts by weight: 5-15 parts of rheum officinale, 4-8 parts of bletilla striata, 15-25 parts of astragalus membranaceus, 5-15 parts of salvia miltiorrhiza, 1-5 parts of cinnamon and 0.5-1.5 parts of borneol. The wound and ulcer paste loaded with the traditional Chinese medicine compound for promoting chronic wound healing can continuously and stably act on a target organ, the wound is isolated from the outside to prevent infection, meanwhile, the drug effect can be better brought into play, and therefore the treatment effect of chronic wound healing is improved.

The invention belongs to the technical field of traditional Chinese medicine preparations, and provides an external tincture patch for treating lumbago in the traditional Chinese medicine internal medicine department and a preparation method, the tincture patch is composed of a solvent and effective components, and the effective components comprise 10-12 g of scalded rhizoma cibotii, 10-12 g of radix angelicae pubescentis, 10-12 g of salted eucommia ulmoides, 8-12 g of achyranthes bidentata, 6-10 g of safflower carthamus, 8-10 g of wine-processed ligusticum wallichii, 12-15 g of lycopodium clavatum, 12-15 g of impatiens balsamina, 6-9 g of frankincense, 6-9 g of myrrh and 3-5 g of natural borneol. The external tincture patch for the lumbago in the traditional Chinese medicine internal medicine department sequentially comprises a backing layer, a medical pressure-sensitive adhesive layer and an anti-seepage ring from bottom to top, an adsorption layer for soaking a tincture to a saturated state is arranged on the inner side of the anti-seepage ring, and the preparation method of the external tincture patch comprises the steps of traditional Chinese medicine processing, tincture extraction, patch forming and the like. The medicine is efficiently extracted through an ethanol solvent, transdermal absorption of the medicine is promoted, and the product is simple and convenient in preparation process, low in cost and convenient for a patient to use by himself or herself and carry daily.

The invention belongs to the technical field of external traditional Chinese medicine ointment, and particularly relates to traditional Chinese medicine ointment for treating arthralgia. The traditional Chinese medicine composition specifically comprises the following raw materials: ground beetles, saline scorpions, centipedes, leeches, earthworms, silkworm larva, cantharides, rhizoma drynariae, shelled semen strychni, corydalis amabilis, peach kernels, saffron crocus, notopterygium roots, gentiana macrophylla, trogopterus dung, buttercup, cottonrose hibiscus leaves, borneol and musk. According to the invention, synergy of insect drugs and botanical drugs for dispelling wind and promoting blood circulation is taken as a core, and the composition is adapted to complex syndromes of arthralgia. The problems of component inactivation, degradation and insufficient extraction are avoided by adopting split-phase extraction; controlled-release microcapsules are separately arranged for high-risk groups such as cantharides to reduce stimulation and slow release, borneol and musk are included to increase stability, and infiltration promotion and slow release are complementary; an oil-water system is constructed by the cream matrix, and the cream has sealing performance, spreadability and residence performance and is suitable for external massage.

The invention relates to the technical field of organic synthesis, in particular to a refining method of a crude product of dextroborneol, which comprises the following steps: sequentially carrying out a rearrangement reaction, an esterification reaction, a salt forming reaction, an alkaline hydrolysis reaction and post-treatment refining on the crude product of dextroborneol in the presence of a solvent and a catalyst on the basis of a reaction product to obtain a refined product of dextroborneol, in the refined dextroborneol product, the content of dextroborneol is greater than or equal to 98.0%, the content of L-borneol is less than or equal to 1.0%, the content of isoborneol is less than or equal to 0.15%, the content of natural camphor is less than or equal to 0.15%, and the content of other impurities is less than or equal to 0.10%. The method has the advantages that the isoborneol structure can be selectively destroyed under mild conditions, impurities are effectively removed through the esterification-salification-alkaline hydrolysis three-step reaction, and the purity and yield of dextroborneol are remarkably improved.

The application provides a white-borneol apricot kernel face mask liquid and a preparation method and application thereof, and relates to the technical field of cosmetics. The preparation raw materials of the white-borneol apricot kernel face mask liquid provided by the application include white petrolatum 5-20 parts, mono-diglyceride 1-10 parts, methyl p-hydroxybenzoate 0.01-8 parts, glycerol 1-10 parts, butanediol 0.05-10 parts, Tween-80 0.05-12 parts and compound extraction liquid 10-30 parts in terms of weight percentage. The white-borneol apricot kernel face mask liquid provided by the application has good moisturizing effect, is cold and heat resistant, has good stability and meets the microbial detection standard of cosmetics.

The application discloses a traditional Chinese medicine composition for treating lumbago, a preparation and a preparation method. The traditional Chinese medicine composition comprises peach kernel, Sanqi, frankincense, myrrh, safflower, dragon's blood, native copper, human hair, rhizoma sparganii, kochia sieboldii, croton tiglium, radix et rhizoma rhei, sweet cinnamon, radix styrax, cassia, fennel, radix angelicae pubescentis, radix et rhizoma aconiti, elder, radix aconiti, kaempferia rotunda, radix puerariae, radix bupleuri, radix angelicae sinensis, apricot kernel, white mustard seed, rhizoma arisaematis, pinellia ternata, scorpion, gastrodia elata, centipede, borneol, schisandra chinensis, sesame oil, zhangdan and old vinegar. The traditional Chinese medicine composition is prepared into a paste, is externally attached to a lumbago part, can eliminate the edema of the lumbar soft tissue of the governed area caused by the intervertebral disc herniation and the like, improves the pain symptom of the lumbar part, and effectively improves the life quality of patients.

The invention discloses a production method of a hexafluorophosphate product, the hexafluorophosphate product is 2-(inner-5-norbornene-2, 3-dicarboximide)-1, 1, 3, 3-tetramethylurea hexafluorophosphate, the first-step reaction of the invention comprises the following steps: preparing an intermediate from norbornene dianhydride as a raw material and a hydroxylamine compound under the action of organic alkali; in the second-step reaction, the intermediate and TCFH are subjected to a nucleophilic substitution reaction under the action of an alkaline metal catalyst to obtain a crude product, and the crude product is purified to obtain a target product; the synthesis route used in the invention is simple, special high temperature or high pressure is not needed in the reaction process, and the used catalyst is a conventional raw material which is low in price and easy to obtain; according to the method, the purity of the product can be increased to 99.8% or above, the total yield is stabilized to be 85% or above, in addition, the reaction route greatly reduces side reactions, and by-products in the product are few in variety and low in content.