606 results about "Borneol" patented technology

The invention relates to the field of traditional Chinese medicine, and discloses a traditional Chinese medicine composition for treating cognitive impairment of Parkinson's disease and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 180-220 parts of vinegar tortoise plastron, 90-110 parts of morinda officinalis, 90-110 parts of angelica sinensis, 90-110 parts of radix curcumae, 55-65 parts of rhizoma acori graminei, 55-65 parts of polygala tenuifolia, 180-220 parts of calcined dragon bone, 180-220 parts of caulis spatholobi and 1-3 parts of borneol. When all the medicines of the traditional Chinese medicine composition are combined, the compatibility of monarch, minister, assistant and guide is performed, so that the traditional Chinese medicine composition has the effects of tonifying kidney, promoting blood circulation, dispersing blood stasis and inducing resuscitation, can relieve cognitive impairments such as space navigation, space exploration, working memory and the like of a Parkinson's disease cognitive impairment model mouse caused by chronic hypoperfusion, and realizes the treatment effect on the Parkinson's disease cognitive impairment; good application prospects are realized.

The invention provides a method for producing borneol, the method comprising culturing the transgenic microorganism in a culture medium, and the microorganism comprises or expresses borneol diphosphate synthetase and phosphatase.

The invention relates to the technical field of plant essential oil products, and discloses a refreshing composition based on plant essential oil and a preparation method thereof.The method comprises the steps that an essential oil composition containing menthol, borneol, lime oil, patchouli oil, lavender oil, basil, pelargonium graveolens oil, clove oil and eucalyptus globulus leaf oil is prepared; constructing an ionic gel slow-release base layer; forming a plant source emulsifier composite two-phase system; and adding a light protection and anti-oxidation protection layer. According to the invention, the stability of the essential oil composition in an environment with change of illumination, temperature and humidity is remarkably improved, precise controlled release of essential oil components is realized, and the technical problems that a traditional essential oil product is easy to volatilize and poor in stability and different hydrophilic essential oil components are difficult to effectively load and release at the same time are solved.

The invention discloses a water-soluble bornyl ester compound and application thereof, the structure of the water-soluble bornyl ester compound is as shown in general formula I, R is acetic acid 2-oxoethyl ester of organic heterocyclic ring, amino acid 2-oxoethyl ester, glycolate of amino acid, acetal of monodisperse polyethylene glycol chain, carbonate, ester or glycosyl; the compound is good in water solubility, the problems that borneol is difficult to dissolve in water and difficult to prepare can be well solved, and in an inflammatory depression animal model, the bornyl ester compound shows good anti-inflammatory, anti-depression and cerebral apoplexy treatment effects and has great application prospects.

The invention discloses a collateral-dredging and pain-relieving gel plaster and a preparation method thereof. The collateral dredging and pain relieving ointment is prepared from the following raw materials in percentage by mass: camphor, borneol, menthol, absolute ethyl alcohol, collateral dredging and pain relieving volatile oil, a surfactant, collateral dredging and pain relieving extract, tartaric acid, purified water, partially neutralized sodium polyacrylate, a cross-linking agent, an adhesive, glycerol, EDTA-2Na (Ethylene Diamine Tetraacetic Acid) and a filling agent. The plaster disclosed by the invention is high in application comfort, breathable, free from aching feeling after being uncovered, free from residue on skin and not sticky when being in contact with sweat; the use of an organic solvent is basically avoided in the production process; the matrix contains components such as water and glycerol, has the effects of moistening the skin and promoting skin hydration, and is free of irritation and sensitization to the skin; repeated uncovering and pasting can be achieved, and the viscosity influence is small.

The invention discloses a gel dressing for treating haemorrhoids and a preparation method of the gel dressing. The gel dressing is prepared from the following raw materials in parts by weight: modified chitosan, multifunctional lipidosome, fructo-oligosaccharide, hyaluronic acid, carbomer, glycerol and recombinant human epidermal growth factors. Chitosan has good film-forming property and antibacterial activity, when haemorrhoids are cracked and bleeding due to long-term constipation, a wound surface is in a high-pH and high-ROS environment, the modified chitosan forms a compact protective film on the ulcerated wound surface, the multifunctional lipidosome with contracted film holes and larger particle size is blocked outside, heparin molecules are grafted on the modified chitosan, and the heparin molecules are grafted on the surface of the wound surface. Recombinant human epidermal growth factors are allowed to pass through, and wound healing is accelerated. When the ulceration part is gradually healed, the pH and ROS level return to normal, the protective film of the modified chitosan is expanded, and the multifunctional liposome is diffused and degraded through the protective film to release the pepper extract, the borneol and the menthol. Fructo-oligosaccharide is added to maintain normal flora balance in the anorectum area.

The invention belongs to the technical field of external preparations, and provides compound itching-relieving cream as well as a preparation method and application thereof. The compound itching-relieving ointment is prepared from the following components in parts by weight: 3 to 6 parts of rhizoma coptidis, 9 to 15 parts of radix scutellariae, 9 to 15 parts of radix et rhizoma rhei, 3 to 6 parts of herba schizonepetae, 3 to 6 parts of herba menthae, 1 to 3 parts of cortex moutan, 1 to 3 parts of sandalwood and 0.5 to 1 part of borneol. The compound antipruritic ointment has the effects of cooling, relieving itching, detoxifying and diminishing swelling, and is used for treating itching and eczema dermatitis itching caused by biting of various small insects such as mosquitoes and the like. According to the compound antipruritic ointment disclosed by the invention, a plurality of components are in synergistic interaction, so that a multi-target and multi-layer treatment effect is realized. The traditional Chinese medicine composition can be used for cooling, relieving itching, detoxifying and diminishing swelling from the source while quickly relieving itching, and a comprehensive and effective solution is provided for itching.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to application of a traditional Chinese medicine composition in preparation of anti-hepatoma medicines. The traditional Chinese medicine composition comprises red ginseng, ox horn tip, musk, borneol, safflower, bezoar, radix aconiti lateralis praeparata slice, venenum bufonis, pseudo-ginseng, benzoin and pearl. Experimental results show that the traditional Chinese medicine composition can induce apoptosis and necrosis of liver cancer cells and inhibit proliferation of the liver cancer cells; and liver cancer cells are retarded to be in a G1 cell cycle. Therefore, the invention provides a new therapeutic drug for clinical treatment of liver cancer, and the raw materials are natural medicinal materials, have wide sources and have good application prospects.

The invention discloses a phlebitis treatment gel containing a coptis chinensis-wine-treated rhubarb compound component and a preparation method of the phlebitis treatment gel. The active ingredients of the gel are coptis chinensis, rheum officinale and wine-treated rheum officinale in a mass ratio of (1.5-2.5): (1.5-2.5): 1, preferably 2: 2: 1. Lavender essential oil, tea tree essential oil, folium eucalypti essential oil and vinegar frankincense, radix trichosanthis and other traditional Chinese medicine auxiliary materials are used as auxiliary materials. The preparation method comprises the following steps: extracting twice with ethanol, mixing extracting solutions, adding borneol, menthol and essential oil, and finally gelling with carbomer. The phlebitis gel can be independently used or combined with indometacin to form dual-channel anti-inflammation, and the defects of skin atrophy, toxicity accumulation and the like of traditional phlebitis gel are overcome. The traditional Chinese medicine composition is clinically expanded and applied to first-stage pressure sores (without skin damage), acnes and mosquito bites, red and swollen of the first-stage pressure sores fade away within 3-5 days, red and swollen of the acnes are relieved by more than or equal to 60% when the traditional Chinese medicine composition is combined with oral medicine for 48 hours, the itching relieving effect on the mosquito bites is less than or equal to 30 minutes, and the curative effect on phlebitis is remarkably superior to that of 50% magnesium sulfate (Plt;

The invention provides a preparation method and application of borneol water with high natural borneol content, and belongs to the technical field of medicines, daily chemicals and aromatherapy. The invention provides a preparation method of borneol water with high natural borneol content, and the borneol water is prepared by directly adopting fresh crushed cinnamomum camphora leaves as a borneol donor based on a two-stage vacuum steam distillation-cyclodextrin reversible carrying coupling process. According to the method, through a'two-stage vacuum steam distillation-cyclodextrin reversible carrying 'coupling process, the content of borneol in a water phase reaches 0.60 + / -0.05 g / 100mL, the chemical purity is greater than or equal to 96%, and meanwhile, long-term clarification and stability are ensured. The obtained borneol water can be effectively used for treating infant eczema, chronic kidney disease related pruritus and relieving / inhibiting pain in the acute outbreak period of gout.

The present application relates to bicyclo[2.2.1]hept-5-en-2-ol and related compounds, methods of making them, and methods of using them as flavor and fragrance ingredients in food, cosmetic, pharmaceutical, consumer, and other compositions and products.

The invention belongs to the technical field of plant tissue culture, and particularly relates to an induction method of adventitious roots of cinnamomum camphora. According to the method disclosed by the invention, the adventitious root induction rate of the adventitious root of the cinnamomum camphora is remarkably improved by establishing a sterile system of the cinnamomum camphora, culturing cluster buds and sterile seedlings, promoting rooting of tissue culture seedlings, inhibiting browning, enabling the adventitious buds to extend and inducing the adventitious root through three ways, so that the problems of shortage of borneol resources and high market demand are solved; the method for inducing the adventitious roots of the cinnamomum camphora can be used for industrial production, and sufficient raw materials are provided for extraction of borneol; according to the method, large-scale culture of the adventitious roots of the cinnamomum camphora is achieved, a large number of pharmaceutical raw materials can be obtained at low cost in a short time, and an integrated production system can be formed with the pharmaceutical industry. The technology has important practical significance for promoting the development of the cinnamomum camphora industry, expanding the application of the pharmaceutical field, constructing a rare and endangered traditional Chinese medicinal material breeding technology system and realizing sustainable development and utilization.

The application relates to a cyclodextrin grafted N-cationic borneol ester polymer antibacterial material, which has the following structure: wherein x is the structural unit number of the N-cationic borneol ester, that is, the polymerization degree, x=20-100; X ‑ =F ‑ , Cl ‑ , Br ‑ or I ‑ . Meanwhile, the application also discloses a synthesis method of the polymer antibacterial material. The natural cyclic oligosaccharide antibacterial material grafted with natural active molecules has higher antibacterial activity, broad-spectrum antibacterial performance and good biocompatibility, can be applied to the biomedical field, and can be used for preparing fruit preservative materials, antibacterial coating, antibacterial fabric and other antibacterial materials.

The invention discloses a preparation method of N-hydroxyl-5-norbornene-2, 3-dicarboximide sulfonate, which is characterized in that the N-hydroxyl-5-norbornene-2, 3-dicarboximide sulfonate is used as a raw material. The preparation method comprises the following step: in the presence of alkali, carrying out esterification reaction on a compound II and a compound III in a solvent to obtain a compound I. The preparation method disclosed by the invention can be used for obtaining a high-purity product with high yield and has a good industrial production prospect.

This invention relates to the field of traditional Chinese medicine (TCM) technology, specifically to a nasal massage oil, its preparation method, and its application. The nasal massage oil is prepared from the following TCM raw materials in the indicated weight proportions: 4-6 parts of roasted Xanthium sibiricum, 1.5-3.5 parts of Magnolia biondii, 1.5-3.5 parts of Angelica dahurica, 0.3-0.7 parts of Mentha haplocalyx, 0.8-1.2 parts of Borneol, 2-4 parts of Sinapis alba, 1-3 parts of Artemisia argyi, 1-3 parts of Carthamus tinctorius, 1-3 parts of Cinnamomum cassia, 2-4 parts of Pueraria lobata, and 80-120 parts of sesame oil as a base. This application, through scientific formulation and reasonable proportioning, effectively solves the technical problem that existing nasal massage mediums only provide lubrication and lack targeted TCM conditioning effects, failing to achieve synergistic effects between massage and medication. It achieves an integrated effect of "massage lubrication - drug penetration - TCM conditioning."

The invention belongs to the technical field of traditional Chinese medicines, and provides a badger fat compound external preparation for treating radioactive skin injury. According to the traditional Chinese medicine differentiation of radioactive skin injury, the compound preparation is prepared by selecting a method of clearing away heat and toxic materials, eliminating dampness, promoting blood circulation, removing blood stasis, removing slough, promoting granulation, cooling blood and nourishing yin, and comprises the following main components: raw rhubarb, lithospermum, sanguisorba officinalis, aloe, folium isatidis, cottonrose hibiscus leaves, dandelion, badger fat and borneol. The compound preparation is prepared from Chinese herbal medicines and badger fat according to unique pathological characteristics of radioactive skin injury, and has a better treatment effect on radioactive skin injury, especially moderate and severe injury.

The present application relates to a pharmaceutical composition comprising an NRF2 agonist and borneol, both of which synergize in a specific molar ratio range, enhance the overall anti-inflammatory and antioxidant biological activity of the drug, improve the oral bioavailability and target tissue distribution of the drug, inhibit the off-target side effects of the NRF2 agonist, and significantly improve the effectiveness and safety of the drug.

The invention belongs to the technical field of medicinal chemistry, and relates to 3-amino-4-(2, 4, 5-trifluorophenyl) bornyl butyrate as well as a preparation method and application thereof. The 3-amino-4-(2, 4, 5-trifluorophenyl) bornyl butyrate has the following structure: the 3-amino-4-(2, 4, 5-trifluorophenyl) bornyl butyrate provided by the invention has an excellent hypoglycemic effect, has a low toxic effect on AC16 cells, and provides a treatment choice with better efficiency and higher safety for diabetics.

The invention discloses a compound scar ointment and a preparation method thereof, the ointment is prepared by decocting and concentrating Chinese herbal medicines such as salvia miltiorrhiza, cassia twig, radix paeoniae alba, rheum officinale, radix sophorae flavescentis, pepper, folium artemisiae argyi, lycopodium clavatum, garden balsam stem, pawpaw and borneol as raw materials and adding a matrix. The ointment has the effects of promoting blood circulation to remove blood stasis, relaxing tendons, activating collaterals, clearing heat and eliminating dampness, can effectively inhibit scar hyperplasia and promote scar softening and dissipation, and is suitable for treating various scars and acne marks. The ointment is simple in preparation process, green and environment-friendly, safe and non-irritant to use, good in clinical effect and wide in application prospect.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a medicine patch needle for preventing and treating allergic rhinitis and a preparation method and application thereof. The medicine patch needle mainly comprises a traditional Chinese medicine composition and a medicine patch thumbtack needle, and the traditional Chinese medicine composition is prepared from, by weight, 30-60 parts of radix astragali, 15-30 parts of radix angelicae sinensis, 10-25 parts of radix saposhnikoviae, 10-30 parts of rhizoma atractylodis, 10-30 parts of rhizoma acori graminei, 5-15 parts of herba asari, 10-30 parts of rhizoma chuanxiong, 10-20 parts of radix angelicae and 1-5 parts of borneol. The medicine needle patch can be used for preventing and treating allergic rhinitis, mild and lasting acupuncture stimulation is achieved on the skin part of the acupoint, the medicine can rapidly enter the acupoint along with the needle hole, in other words, the acupoint achieves the effects of harmonizing qi and blood, relieving stuffy nose and removing pathogenic qi under the dual action of the acupuncture stimulation and the medicine, and the medicine needle patch has the remarkable preventing and treating effect on the allergic rhinitis.

The invention relates to a pharmaceutical composition, which is prepared from adapalene, benzoyl peroxide, a traditional Chinese medicine extract, an acrylamide and acryloyl dimethyl sodium taurate copolymer, a mixture of isohexadecane and polysorbate 80, docusate sodium, EDTA (Ethylene Diamine Tetraacetic Acid) disodium, glycerol, poloxamer 124, propylene glycol and water, the traditional Chinese medicine extract comprises moutan bark, salvia miltiorrhiza, radix rehmanniae recen, radix sophorae flavescentis, coptis chinensis, rheum officinale, scutellaria baicalensis, menthol and borneol. According to the pharmaceutical composition disclosed by the invention, the synergistic antibacterial and anti-keratosis curative effects of adapalene and benzoyl peroxide can be maintained, and meanwhile, the occurrence rate of local skin dryness, erythema, desquamation, burning heat sensation and contact dermatitis can be remarkably reduced.

The invention provides a traditional Chinese medicine composition for treating cerebrovascular diseases and a preparation method and application thereof, and belongs to the technical field of biological medicine. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 8 to 12 parts of rhizoma chuanxiong, 12 to 17 parts of radix paeoniae rubra, 13 to 18 parts of radix salviae miltiorrhizae, 8 to 12 parts of radix polygalae, 10 to 15 parts of rhizoma acori graminei, 27 to 32 parts of radix astragali seu hedysari, 0.3 to 0.7 part of borneol, 0.1 to 0.2 part of musk, 12 to 18 parts of radix angelicae sinensis, 6 to 12 parts of flos carthami, 7 to 12 parts of semen persicae and 5 to 7 parts of radix glycyrrhizae preparata. The traditional Chinese medicine composition disclosed by the invention has the curative effects of tonifying qi and activating blood, dispersing blood stasis and dredging collaterals, and restoring consciousness and inducing resuscitation. The traditional Chinese medicine composition can be combined with a leg electrical stimulation system to efficiently treat cerebral apoplexy hemiplegia and effectively treat vascular dementia, and has an obvious treatment effect on cerebrovascular diseases. The preparation method of the traditional Chinese medicine composition is simple, convenient and rapid, and is suitable for industrial production.

The invention discloses a moxa stick containing traditional Chinese medicine components for treating infertility and a preparation method of the moxa stick, relates to the technical field of traditional Chinese medicine instruments, and mainly solves the technical problem of low skin permeation efficiency of the medicine components in the moxibustion process. According to the technical scheme, the preparation method comprises the following steps: preparing traditional Chinese medicine powder consisting of angelica sinensis, prepared rehmannia root, semen cuscutae, fructus lycii, ligusticum wallichii, rhizoma cyperi, salvia miltiorrhiza and borneol according to specific parts by mass, and controlling the average particle size to be 10-50 microns; the moxa and the traditional Chinese medicine powder are mixed according to the mass ratio of (3-5): 1 to form a medicine core layer; the periphery of the medicine core layer is wrapped with a pure moxa heat conduction layer with the thickness of 2-4 mm; and finally, wrapping the periphery of the heat conduction layer with a mulberry paper barrier layer with the thickness of 0.1-0.3 mm. Through the combined action of the three-layer structure, the medicine release and heat conduction path is optimized, the medicine transdermal efficiency is remarkably improved, and the high-efficiency traditional Chinese medicine moxa stick for treating infertility is prepared.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a traditional Chinese medicine compound antibacterial gel for promoting blood circulation to remove meridian obstruction and a preparation method thereof. The traditional Chinese medicine compound antibacterial gel for promoting blood circulation to remove meridian obstruction is prepared from the following components in percentage by mass: 0.01 to 0.03 percent of benzalkonium chloride, 0.02 to 0.05 percent of aromatic phenol acetate, 1 to 2.5 percent of propylene glycol, 0.01 to 0.05 percent of menthol, 0.3 to 0.6 percent of traditional Chinese medicine extracting solution, 0.01 to 0.05 percent of ginger root oil, 0.5 to 1 percent of pandan butyl ether, 0.01 to 0.05 percent of borneol, 0.3 to 5 percent of modified hydroxyethyl cellulose and the balance of water. The gel can relieve tissue edema and improve microcirculation and tissue oxygen supply; meanwhile, by combining with antibacterial components, the anti-infection effect can be synchronously achieved, the effects and advantages of promoting blood circulation and dredging collaterals of the traditional Chinese medicine compound are complementary, the better treatment effect is achieved, and the wound healing quality and speed are improved.

The invention discloses a traditional Chinese medicine composition and a traditional Chinese medicine ointment for treating acute knee joint traumatic synovitis, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for treating acute knee joint traumatic synovitis is prepared from the following raw materials in parts by weight: 10 to 20 parts of notopterygium root, 10 to 20 parts of radix angelicae pubescentis, 3 to 5 parts of herba ephedrae, 8 to 15 parts of rhizoma curcumae longae, 5 to 10 parts of vinegar frankincense, 5 to 10 parts of vinegar myrrh, 10 to 25 parts of radix achyranthis bidentatae, 8 to 10 parts of radix et rhizoma rhei, 5 to 15 parts of flos carthami, 15 to 25 parts of caulis spatholobi, 15 to 25 parts of borneol, 25 to 35 parts of dragon's blood, 7 to 9 parts of ground beeltle, 25 to 35 parts of radix notoginseng and 5 to 10 parts of native copper. The traditional Chinese medicine composition is reasonable in compatibility, rich in raw materials and effective in combination of the components, has the effects of removing blood stasis, dredging collaterals, promoting blood circulation and dispersing swelling, is effectively used for treating acute knee joint traumatic synovitis, is convenient to use and good in effect, is an innovation of medicines for treating acute knee joint traumatic synovitis, and has good popularization and application values and practical clinical significance.

The invention relates to the technical field of health-care external application agents, in particular to Qianzhou treatment Shukangtang tendon-relaxing and bone-penetrating health-care paste which is formed by combining subpackaged powder and subpackaged liquid. The powder comprises a mixture of the following Chinese herbal medicines according to a mass ratio: safflower, homalomena occulta, radix angelicae pubescentis, verbena, dragon's blood and centipede, and each component can be adjusted in a range of + / -20% as required; the liquid is based on a soaking decoction obtained by soaking and decocting safflower, radix angelicae, caulis spatholobi and mint as main medicinal materials in water, filtering and cooling, the content of ethanol in the liquid is 2-12%, the content of glycerol in the liquid is 1-6%, and the dosage of borneol is 0.1-2.0 g; the powder is a Chinese herbal medicine powder mixture which is dried, crushed and sieved. According to the invention, powder and liquid are subpackaged, and detectable indexes such as granularity, moisture and auxiliary material ratio and the like are determined, so that the standardization and repeatability of the formula and the process are realized, the stability and the transdermal permeation efficiency of the product are obviously improved, and the curative effect similar to that of a store can be obtained after on-site / family rapid blending.

The present application relates to the technical field of wound repair, and provides a traditional Chinese medicine composition for promoting wound healing and a preparation method thereof.The traditional Chinese medicine composition comprises a first traditional Chinese medicine composition and a second traditional Chinese medicine composition which are applied to the acute phase and the repair proliferation phase.The former comprises naked flower purple perilla extract, nectarine leaf extract, purple perilla extract, dragon's blood micro powder, spironast extract, centella asiatica volatile oil, rhubarb extract, borneol, mussel mucin, medicinal glycerol and purified water.The latter comprises red algae extract, nectarine leaf extract, radix astragali extract, panax notoginseng total saponins, aloe extract, dendrobium officinale extract, sea buckthorn extract, pinctada martensii purified peptide, snail glycosaminoglycan, medicinal glycerol and purified water.The composition can play the roles of antibiosis, anti-inflammation, hemostasis, analgesia and astringency in the acute phase, and can promote angiogenesis, collagen synthesis and epithelial regeneration in the repair proliferation phase, so that the wound is rapidly repaired and healed.

The invention provides pain-relieving and stasis-dissipating powder for treating soft tissue and gout, and relates to the technical field of traditional Chinese medicines. The pain-relieving and stasis-dissipating powder for treating soft tissue and gout is prepared from cortex phellodendri, fructus gardeniae, frankincense, myrrh, radix et rhizoma rhei, radix angelicae sinensis, radix angelicae and borneol. The pain-relieving and blood stasis-dissipating powder has the effects of promoting blood circulation to remove blood stasis, relieving swelling and pain, clearing heat, eliminating dampness, removing blood stasis and promoting tissue regeneration, and has a remarkable curative effect on early fracture, soft tissue injury, gout, synovitis and the like.

The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by mass: 5 to 10 parts of cortex phellodendri, 5 to 10 parts of radix scutellariae, 5 to 10 parts of radix notoginseng, 5 to 10 parts of melastoma dodecandrum lour, 8 to 15 parts of herba lycopi, 8 to 15 parts of rhizoma alismatis, 8 to 15 parts of herba lycopodii, 12 to 18 parts of semen coicis, 1 to 3 parts of borneol, 135 to 150 parts of beewax and 390 to 400 parts of sesame oil. The She nationality characteristic medicinal material melastoma dodecandrum serves as a core component, the Qi and blood theory of traditional Chinese medicine is combined, multiple blood circulation promoting and stasis removing medicinal materials are combined, the comprehensive treatment effects of promoting blood circulation to remove swelling, regulating Qi to dissipate blood stasis and stopping bleeding and relieving pain are jointly achieved, the red, swollen and heat pain symptoms in the acute stage of fracture and sprain can be remarkably relieved, and the curative effect is good. The traditional Chinese medicine composition has the action trend of reducing local exudation and preventing swelling persistence, and has a practical clinical external treatment value for promoting early functional recovery of wounds.

The present application relates to a kind of hyperbranched polymer, nano preparation and its preparation method and application, belong to functional medical material and nanotechnology field.The hyperbranched polymer of the present application can be broken in ROS environment Release dihydrolipoic acid, play the role of antioxidant, be reduced to lipoic acid in vivo, and then play its role as coenzyme, participate in mitochondrial tricarboxylic acid cycle, restore mitochondrial function, thereby play the role of antioxidant and play the role of treating ischemic stroke.The nano preparation provided by the present application can be quickly distributed to brain in a short time, temporarily increase the paracellular permeability of BBB by inhibiting the expression of multi-drug resistance protein P-gp and ATP-dependent drug efflux protein on BBB, and the process of opening BBB by borneol is physiological and reversible, without destroying the structural integrity of blood-brain barrier.