The present invention relates to compositions and uses for the treatment of folliculitis. The composition includes mussel soft tissue extract, trypsin, green tea extract, and coffee bean extract, and may optionally include other carriers. The object of the present invention is to provide a composition for the treatment of folliculitis with fast onset, good curative effect and no toxic and side effects, which can control oil secretion, inhibit inflammation, and effectively relieve cysts, itching, ulcers, nodules, etc. caused by folliculitis. Symptoms such as pustules, skin itching, armpit pain, turbinate swelling, furuncle, etc. have the advantages of quick effect, high cure rate, no toxic side effects, safety and convenience for the treatment of folliculitis, and are easy to prepare, and can be widely used in the treatment of folliculitis. treat.