83 results about "Local anesthetic" patented technology

The invention relates to the technical field of biological pharmacy, and discloses a QS-21 saponin adjuvant as well as a preparation method and application thereof, the adjuvant is a composite liposome and comprises a liposome skeleton composed of distearoyl phosphatidylcholine and cholesterol, and QS-21 saponin, monophosphoryl lipid A and a local anesthetic are jointly entrapped in the liposome skeleton. The problem that high reactogenicity and immunogenicity of potent adjuvants are difficult to consider at the same time is solved, the immunostimulation component and the pain inhibition component are jointly entrapped in the same nano-carrier, collaborative delivery in injection local is achieved, and therefore pain and swelling caused by the adjuvants are accurately inhibited. The co-entrapment structure avoids the potential inhibition effect of the free anesthetic on the immune system, the potent body fluid and cellular immune enhancement activity of the adjuvant is completely reserved, and a new technical scheme is provided for developing vaccines with high safety and strong immune efficacy.

The invention discloses oral multi-effect analgesic and anti-inflammatory gel and a preparation method thereof, and belongs to the technical field of medical gel. The gel is prepared from mussel mucin grafted hydroxypropyl chitosan, a poly (N-isopropylacrylamide)-co-acrylic acid copolymer, quercetin-zinc coordination nanoparticles, a local anesthetic compound wrapped by temperature-sensitive lipidosome, a gamma-polyglutamic acid-catechin gel matrix, aloe polysaccharide, dipotassium glycyrrhizinate, and sodium hyaluronate and potassium sorbate which can be selectively added, wherein the local anesthetic compound is prepared from the mussel mucin grafted hydroxypropyl chitosan, the poly (N-isopropylacrylamide)-co-acrylic acid copolymer, the quercetin-zinc coordination nanoparticles, the temperature-sensitive lipidosome, the gamma-polyglutamic acid-catechin gel matrix, the aloe polysaccharide and the dipotassium glycyrrhizinate. During preparation, part of the components and water are stirred to obtain a mixed solution, and then the other components are added and stirred into gel. According to the gel, the leakage rate of local anesthetics is reduced by stabilizing the liposome through the zinc ions, the quercetin adjusts the phase transition temperature of the liposome to realize preferential drug release at the pain part, the mussel mucin and the copolymer form a reversible hydrogen bond network to enhance the mucous membrane adhesive force, and the inflammatory environment triggers the gel permeation drug release, so that the gel has the advantages of multiple-effect synergy, strong adhesion and the like; the problems that existing oral gel is short in analgesia time and insufficient in anti-inflammation can be effectively solved.

This invention belongs to the field of biomedical materials technology, and particularly relates to an analgesic microneedle patch, its preparation method, and its application. The analgesic microneedle patch of this invention uses extracted mesenchymal stem cell exosomes and ginger exosomes as analgesic active substances, and by combining them with microneedle patch technology, it provides a new technical approach for surface anesthesia. The analgesic microneedle patch of this invention combines microneedle technology and photopolymerization 3D printing technology to develop a customizable hydrogel microneedle patch, achieving minimally invasive and precise percutaneous delivery of local anesthetics, providing a new technical approach for surface anesthesia.

The invention discloses a compound with a local anesthesia function as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The preparation method of the compound comprises the following steps: mixing and heating lidocaine and 2-bromoethanol to obtain a compound 1; the preparation method comprises the following steps: mixing dicarboxylic acid, N-hydroxysuccinimide, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and a solvent to obtain a mixed solution; mixing and dissolving a compound 1, alkali and a solvent, and then adding into the mixed solution; and then carrying out spin-drying, separation and purification to obtain the compound with the local anesthesia function. The medicine can be used as a local anesthetic or analgesic for long-acting nerve block or selective nerve block. The medicine can block nerve conduction, has biocompatibility and biodegradability, is expected to overcome the problems of short time efficiency of single-needle injection and the like, and improves the efficacy of the medicine.

The invention discloses a CYP3A4 postoperative intercostal nerve block puncture injection supporting device, and relates to the technical field of intercostal nerve block, the CYP3A4 postoperative intercostal nerve block puncture injection supporting device comprises a supporting frame, a concentric-square-shaped cavity is formed in the supporting frame, a soft support is fixedly connected to the rear side of the supporting frame, patches are symmetrically and fixedly connected to the two sides of the soft support, and uncovering pieces are movably bonded to the sides, away from the supporting frame, of the patches; the device further comprises a disinfection mechanism, a power assisting mechanism and a puncture injection auxiliary mechanism, the disinfection mechanism is arranged on the rear side of the supporting frame, the power assisting mechanism is arranged in the concentric-square-shaped cavity, and the puncture injection auxiliary mechanism is arranged on the front side of the supporting frame. The situation that when medical staff conduct puncture injection on the intercostal skin of a patient, the puncture needle deviates from the target position in the intercostal space of the patient or mistakenly penetrates through other tissue, and consequently local anesthetic medicine is injected into a wrong area is avoided, and the effect of relieving postoperative pain through medicine injection is guaranteed.

The invention relates to the technical field of medical monitoring, and discloses an intelligent early warning method and system for local anesthetic poisoning, and the early warning method comprises the steps: obtaining multi-modal data containing the structural features of a patient, physiological time sequence data and an initial ultrasonic image; based on the ultrasonic image, generating a guide signal representing a space risk and a depth space feature vector in parallel; adaptive attention weighting is carried out on the physiological time sequence data under the guidance of a guidance signal representing the spatial risk, and an adaptive time sequence feature vector is generated; and finally, fusing the structural features, the depth space features and the adaptive time sequence features, determining a poisoning risk level, and performing early warning. By fusing the multi-modal data and utilizing the space risk analyzed by the ultrasonic image to guide the analysis focus of the time series data, the method can capture and predict the weak physiological change of the toxic reaction, thereby overcoming the defects of strong subjectivity and response lagging of the traditional monitoring, and improving the timeliness, accuracy and objectivity of early warning.

This invention discloses quaternized chitin, hemostatic sponges, and their preparation methods. First, a quaternization reagent is added to an alkaline urea-chitin aqueous solution at low temperature for homogeneous reaction, preparing temperature- or pH-sensitive quaternized modified chitin. Then, the aqueous solution is freeze-coagulated, regenerated, and purified to produce a sponge material for hemostasis, exhibiting high wet strength. The method of this invention is simple, environmentally friendly, and green, using no chemical cross-linking agents. The material is biodegradable and absorbable in vivo, exhibiting good biocompatibility and biodegradability. This type of hemostatic sponge material absorbs water quickly, possesses good mechanical properties and shape memory properties, provides excellent hemostatic effect, and promotes wound healing. It is particularly suitable for arterial hemostasis and hemostasis of deep and narrow wounds, non-compression wounds, and penetrating wounds. It can also be used as a carrier for sustained-release of local anesthetic analgesics and / or anti-inflammatory and antibacterial drugs.

The present disclosure relates to pharmaceutical compositions comprising a local anesthetic. Specifically, the invention relates to a suspension injection of a local anesthetic, which comprises active ingredient particles, a stabilizer and a liquid medium. The suspension injection can be better applied to clinic.

The present invention relates to the field of pharmaceutical chemistry, and provides a quaternary ammonium salt derivative, and a preparation method therefor and a use thereof. The structure of the quaternary ammonium salt derivative is as shown in formula I. The compound of the present invention has an excellent differential blocking effect on sensory and motor nerves, high safety during use, and a long duration of action. Thus, the compound of the present invention has wide application prospects in the preparation of local anesthetic drugs for sensory-motor dissociation.

Provided herein are compounds that are local anesthetics and useful for inducing selective sensory nerve blockade. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of inducing selective sensory nerve blockade by administering the compounds and / or compositions to a subject.

The present application belongs to the field of biological medicine, and relates to an in-situ spraying particle-gel composite as well as a preparation method and application thereof. The present application prepares a drug-loaded particle-gel composite material, which can be rapidly gelled in-situ in the form of spraying. In a wound infection model of diabetic rats, the composite material exhibits good photothermal activation TRPV1 channel-mediated local analgesia, as well as anti-inflammatory, antibacterial, antioxidant, hemostatic and wound healing-promoting multifunctional therapeutic effects. Through in-vitro and in-vivo material characterization, as well as histopathological examination of animal experiments, it is confirmed that the composite gel material has good biological safety and degradability, and is a local anesthetic biomaterial preparation which is expected to be clinically transformed for chronic wound analgesia and healing-promoting therapeutic effects.

The application relates to the technical field of tracheal catheters, and discloses a medical tracheal catheter with double coatings of local anesthetic and antibacterial drugs, which comprises a catheter main body and a cuff main body connected to the outer wall of the catheter main body, the catheter main body comprises a catheter base material layer, a first transition bonding layer, a first nano local anesthetic coating and a first antibacterial coating; the cuff main body comprises a cuff base material layer, a second transition bonding layer, a second nano local anesthetic coating and a second antibacterial coating; a tracheal tube is mounted on the catheter main body; and a head tube is connected to the bottom end of the catheter main body. The first nano local anesthetic coating, the first antibacterial coating, the second nano local anesthetic coating and the second antibacterial coating are arranged, so that the catheter main body and the cuff main body can realize a synergistic protection mechanism of analgesia and antibiosis; during the process of leaving the catheter, the local anesthetic drug acts on the mucosa of the tracheal wall through slow release, and the antibacterial component effectively reduces bacterial adhesion and biofilm formation.

The utility model discloses a disposable visual laryngoscope capable of preventing fog and realizing surface anesthesia, which comprises a visual display screen, a laryngoscope handle, a laryngoscope lens and an injector, the visual display screen is arranged at one end of the laryngoscope handle, the laryngoscope lens is arranged at the other end of the laryngoscope handle, a camera is arranged at the front end of the laryngoscope lens, and the camera is connected with the visual display screen through a cable. The injector is detachably arranged on the laryngoscope handle and connected with one end of the spray pipe, the other end of the spray pipe extends into the laryngoscope blade from the rear end of the laryngoscope blade and extends out of the front end of the laryngoscope blade, the atomization nozzle is arranged at the front end of the spray pipe and supported and fixed through an adjusting support arranged in the laryngoscope blade, and the fixing plate is arranged on the side wall of the laryngoscope handle. A positioning plate is arranged at one end of the fixing plate, a positioning hole is formed in the positioning plate, and the positioning plate is fixedly connected with a laryngoscope handle through a positioning screw arranged in the positioning hole. The laryngoscope can effectively infiltrate local anesthesia medicine on the throat, and the visual laryngoscope cannot fog when entering the oropharynx.

The present invention provides a method and application for identifying the plane tissue structure of the transverse abdominal muscle based on RMSD-Net, and relates to the field of image processing technology. The method comprises the following steps: performing data preprocessing on an acquired ultrasound image with a plane structure of the transverse abdominal muscle to establish an abdominal ultrasound image dataset; wherein the ultrasound image with the plane structure of the transverse abdominal muscle includes key abdominal tissue structure information that can be observed during TAP block; constructing an RMSD-Net model with a U-shaped network structure; the RMSD-Net model comprises an encoder, a jump connection structure, and a decoder; a multi-scale residual feature extraction module RMDC module is added to each layer of the encoder; the jump connection structure uses a feature fusion module SFF module layer by layer; an attention mechanism GAM module is added to the last layer of the decoder; a segmentation task is performed on the aforementioned key abdominal tissue structure information, the aforementioned abdominal ultrasound image dataset is divided into a training set and a test set, and the aforementioned RMSD-Net model is used for training and testing respectively; the tested RMSD-Net model is used to segment and identify the key abdominal tissue structure information of the newly acquired ultrasound image with the plane structure of the transverse abdominal muscle. The present invention can help clinicians to quickly and accurately interpret ultrasound images with the transverse abdominal muscle plane structure, so as to assist them in accurately locating the blocking area and injecting local anesthetics.

The invention discloses a hydrocortisone compound ointment preparation for treating haemorrhoids, and belongs to the technical field of medicines. The technical problem to be solved is to provide a hydrocortisone compound ointment preparation which has a good hemorrhoid treatment effect and is stable. The hydrocortisone compound ointment preparation comprises the following components in percentage by weight: 0.15%-1% of corticoid, 0.025%-0.1% of a vasoconstrictor, 2%-4% of a local anesthetic, 0.1%-1.5% of L-menthol, 0.02%-0.5% of chlorhexidine acetate and 0.05%-1% of allantoin. The hydrocortisone compound ointment preparation disclosed by the invention has the medicinal effects of relieving pain and discomfort of patients suffering from haemorrhoids, promoting healing and repairing of haemorrhoids tissues, preventing infection and relieving inflammatory response, and has obvious effects of stopping bleeding and relieving swelling and pain in haemorrhoids treatment.

The invention relates to the technical field of medical preparations, and particularly discloses a preparation method and application of an analgesic lubricating coating. According to the coating, local anesthetic loaded lipidosome and dynamic cross-linked hyaluronic acid / carboxymethyl chitosan hydrogel are combined, and the lipidosome not only realizes slow release of the loaded medicine, but also can greatly improve the lubricating property of the gel; according to the hydrogel, injectability, sprayability and self-healing characteristics are obtained by controlling the component proportion, the liquid A and the liquid B are convenient to store separately, and the effects of lubrication enhancement and slow-release analgesia can be achieved by spraying the hydrogel to the surfaces of the tail ends of medical instruments made of various materials to form gel rapidly, so that mechanical injuries and pains related to catheters and implants are relieved, and the hydrogel has a good application prospect. The rapid rehabilitation of the patient is promoted, and good transformation application prospects are realized.

The present invention discloses a sleeve and injection assembly for local anesthetic injection, which relates to the technical field of syringes, and comprises a syringe and a push rod therein that moves axially to assist in pushing the liquid medicine, wherein a piston is fixedly provided at the end of the push rod, and comprises a needle seat provided at the first end of the syringe and used to supply liquid to the needle, on which a liquid medicine tube is provided; and an adjustment sleeve provided for movement along the axial direction, which is driven by a spring to maintain an initial state in which the liquid medicine tube is unobstructed. When the injection pressure of the sleeve and injection assembly for local anesthetic injection is too high, the adjustment sleeve moves axially and is not in the initial state, so that the liquid medicine tube is blocked and liquid intake is stopped. The frictional resistance generated by the expansion bladder on the piston will offset part of the thrust F, making the piston speed slower and further reducing the injection force. At the same time, the setting of the pressure relief valve allows the liquid to overflow into the overflow chamber automatically when the hydraulic pressure is too high. By reducing the hydraulic pressure, the discomfort during the injection process can also be reduced.

This utility model relates to the field of medical device technology, and in particular to a disposable nasal adjustable local anesthetic sprayer, comprising: a spray conduit including a spray end, an infusion end, and a delivery section connecting the spray end and the infusion end respectively; an anesthetic delivery line disposed in the spray conduit, the anesthetic delivery line passing through the infusion end and the delivery section and then communicating with the spray end; a spray device including a first spray element disposed in the inner cavity of the spray end and a second spray element disposed on the outer wall of the spray end; an inflation assembly including an airbag surrounding the delivery section near the spray end, an inflation interface section disposed on the delivery section away from the spray end, and an inflation line passing through the inflation interface section and the delivery section and then communicating with the airbag; and a monitoring device interface section disposed on the outer wall of the infusion end.

The invention discloses a preparation method of an anesthetic taking effect quickly and lasting for a long time. The preparation method comprises the following steps: S1, heating and dissolving a slow-release local anesthetic and an oil phase matrix, cooling, and adding an antioxidant and an emulsifier to form an oil phase; s2, heating the water-phase matrix, adding the bacteriostatic agent, dissolving, cooling, respectively adding the quick-release local anesthetic, the pH regulator, the chelating agent and the film-forming agent, and dissolving to obtain a water phase; s3, under high-speed shearing, the water phase is slowly added into the oil phase, after high-speed shearing and mixing, the thickening agent is added, and filling is carried out, so that the anesthetic is obtained.The prepared anesthetic can form a film for administration during use, no residual medicine adheres to the anesthetic after the film is removed, meanwhile, the anesthetic takes effect quickly and lasts for a long time, the controllability of the anesthetic effect is enhanced, and the experience feeling and satisfaction degree of a user are improved; and the product can be stored at room temperature for more than 12 months.

This invention relates to the field of fluorescent carbon nanomaterials, specifically to highly efficient water-soluble carbon dots for loading local anesthetic drugs, their preparation method, and applications. Using water-soluble amino acids and carboxylic acid compounds that readily aggregate and carbonize to form six-membered rings as precursors, the precursors are sonicated to dissolve them in an organic solvent to form a homogeneous solution. This solution is then transferred to a reaction vessel and subjected to a solvothermal reaction at 180-240°C for 4-10 hours. The reaction vessel is then allowed to cool naturally to room temperature, directly obtaining a carbon dot solution. The obtained carbon dot solution is filtered, eluted, and dried to obtain a solid carbon dot powder. The functionalized carbon dots prepared by this invention possess both good water solubility and high efficiency in loading local anesthetic drugs, showing broad application prospects in the field of sustained-release analgesia of local anesthetic drug formulations.

The application discloses a long-acting local anesthetic compound, a preparation method, application and a pharmaceutical composition thereof. The long-acting local anesthetic compound is prepared by the following steps: reacting a local anesthetic with bromoethanol to generate a quaternary ammonium salt intermediate, and then condensing the quaternary ammonium salt intermediate with a non-steroidal anti-inflammatory drug. The preparation method is simple and suitable for large-scale production. The prepared long-acting local anesthetic compound has a long duration and an anesthetic time of more than 24 hours, and has nerve block selectivity. The long-acting local anesthetic compound can reduce the frequency of administration, increase the compliance of patients, greatly reduce the risk of anesthesia, and has a very good application prospect.

The utility model relates to the technical field of medical instruments, in particular to a local anesthetic sprayer which comprises a liquid storage bottle, the top of the liquid storage bottle is in threaded connection with a connector, a rotary connecting assembly used for being connected with anesthetic liquid in the liquid storage bottle is arranged in the liquid storage bottle, and the top of the rotary connecting assembly is communicated with the connector. One end of the connector is connected with an air blowing assembly used for providing an air source, the other end of the connector is connected with a spraying assembly used for conveying anesthetic liquid to an affected part, and the air blowing assembly and the spraying assembly are both communicated with the connector. When the liquid storage bottle inclines, the bottom of the rotary connecting assembly can go deep into anesthesia liquid in the liquid storage bottle all the time, it is avoided that air is directly sprayed out in the anesthesia process, and secondary damage is caused to the affected part of a patient, the spraying efficiency of the spraying assembly is effectively improved, and then the efficiency is improved when a doctor executes the anesthesia step.

The invention discloses an injectable temperature-sensitive hydrogel sustained-release medicinal preparation for in-situ generation of local anesthetic microrods and application of the injectable temperature-sensitive hydrogel sustained-release medicinal preparation in long-acting anesthesia and analgesia. The pharmaceutical preparation comprises three parts: injectable hydrogel, local anesthetic soluble salt and an alkaline pH regulator. An alkaline pH regulator is added into a mixed solution of hydrogel and local anesthetic soluble salt, the local anesthetic soluble salt is induced to be self-assembled in the hydrogel to form a micron-sized rod-like structure, and finally the injectable temperature-sensitive hydrogel pharmaceutical preparation containing the local anesthetic microrod is obtained. The preparation has the advantages of simple preparation, low cost, easily available raw materials, good biocompatibility and the like, can effectively delay the release rate of local anesthetics and prolong the local anesthesia and analgesic effects, and shows good application prospects in the aspect of preparation of long-acting local anesthesia and analgesic drugs.

A bioresorbable, sustained release pharmaceutical composition comprising: 1.8 wt % to 3.0 wt % methylcellulose and 0.1 wt % to 3.0 wt % hyaluronan in the form of a gel polymer matrix, and at least one local anesthetic agent, suitably ropivacaine, which may be administered by injection.

This invention discloses a library of traditional Chinese medicine (TCM) compositions based on general and local anesthesia mechanisms, along with various dosage forms and preparation methods. The invention constructs a systematic library of TCM anesthetic compositions: the general anesthetic composition consists of extracts from herbs such as Datura stramonium, Datura stramonium, processed Aconitum carmichaelii, processed Aconitum kusnezoffii, Saussurea involucrata, Jasminum sambac root, Rhododendron molle, and Sanqie Sanqie; the local anesthetic composition consists of extracts from herbs such as Asarum heterotropoides, Murraya paniculata, Ephedra sinica, Toad venom, and Corydalis yanhusuo. This invention further develops the above compositions into various modern dosage forms, including injections, tablets, capsules, and sprays. In particular, this invention innovatively introduces a clove-cinnamon natural preservative and flavoring system to replace chemical preservatives. In terms of preparation technology, advanced technologies such as supercritical CO2 extraction, microwave-assisted extraction, nano-embedding, and nanoemulsions are integrated, and a self-extraction scheme is adopted to achieve controllable quality and cost. Simultaneously, a quality detection method based on HPLC fingerprinting is established. This invention achieves full-scenario coverage of anesthesia and analgesia, from general to local, from emergency to routine care, with outstanding advantages of safety, effectiveness, and controllable quality.

The application discloses an external use delayed cream with natural ingredients and a preparation method thereof, belongs to the field of traditional Chinese medicine, and particularly relates to an external use delayed cream containing dry toad extract and toad oil and a preparation method thereof. The application is based on the local anesthetic properties of the dry toad extract and the toad oil, and an external use delayed cream is prepared by quantitatively controlling the dosages of the dry toad extract and the toad oil, which is used for treating male premature ejaculation and erectile dysfunction. The preparation has the advantages of direct action, sustained release and simple operation, and the preparation cost is low because the toad killed in breeding is used as a raw material. The application realizes the transformation of toad oil from waste to treasure, fully excavates the medicinal value of the toad oil, further perfects a reasonable utilization system of toad resources, and provides a practical scheme for efficient development of toad medicinal resources.

The invention relates to the technical field of machine vision, and provides a thoracic trunk nerve block auxiliary system, which comprises a wireless ultrasonic probe device used for collecting an ultrasonic image of a thoracic trunk nerve block area of a patient based on a thoracic trunk nerve block scheme of the patient; the thoracic trunk nerve block scheme is generated by the mobile terminal device based on multi-dimensional individual feature information of the patient; the mobile terminal device is used for determining an anatomical structure and a target retardation area based on the ultrasonic image; generating a blocking path based on the thoracic trunk nerve blocking scheme, the anatomical structure and the target blocking area; the target retardation area is an injection area of local anesthetics; and the augmented reality glasses device is used for displaying the ultrasonic image, the anatomical structure, the target retardation area and the retardation path on the real view image of the patient in an overlapping manner. According to the method, individualized retardation scheme recommendation, real-time ultrasonic visual guidance and dynamic retardation path planning are realized, the retardation success rate is improved, and the operation difficulty is reduced.

The invention provides a quaternary ammonium salt derivative as well as a preparation method and application thereof, and relates to the field of medicinal chemistry. The structure of the quaternary ammonium salt derivative is as shown in formula I in the specification. The compound disclosed by the invention is excellent in sensory and motor nerve separation and retardation effect, good in safety during use and relatively long in action time. Therefore, the compound provided by the invention has a wide application prospect in preparation of sensorimotor-separated local anesthetic drugs.

The invention discloses a local anesthetic spraying device capable of improving operation stability for the anesthesiology department, and belongs to the field of medical instruments, a storage cylinder for containing anesthetic liquid is provided, a spraying assembly is arranged on the storage cylinder, and the spraying assembly is used for switching sprayers with different precisions to spray an affected part; the driving assembly is arranged in the storage cylinder, the driving assembly is used for stably extruding the anesthetic liquid medicine in the storage cylinder, and meanwhile, the spraying dosage can be set; the adding assembly is arranged on the storage cylinder; the spraying assembly adapts to different anesthesia scenes by switching sprayers with different precisions, liquid medicine spraying is more targeted, the driving assembly extrudes the liquid medicine through stable power output, force fluctuation of manual pressing is avoided, meanwhile, through the dose setting function, it is ensured that the amount of the liquid medicine sprayed every time is consistent, and the spraying efficiency is improved. Influence of anesthesia effect caused by insufficient dosage or adverse reaction caused by excessive dosage are avoided.