925 results about "Capsaicin" patented technology

The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g., antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction. Further related are methods of using these vehicles alone or in conjunction with antibodies, e.g., uroplakin antibodies, to improve duration of liposome attachment, and provide a long-term intravesical drug delivery platform. The present invention specifically relates to antibody-coated liposomes that are useful for targeting specific receptors for drug, peptide, polypeptide, or nucleic acid delivery. In one particular aspect, the present invention relates to liposomes coated with antibodies against nerve growth factor (NGF) receptor and containing NGF antisense nucleic acids, which are used as a treatment for neurogenic bladder dysfunction.

The present invention provides compositions and methods for relieving pain at a site in a human or animal in need thereof by administering at a discrete site in a human or animal in need thereof a dose of capsaicin in an amount effective to denervate a discrete site without eliciting an effect outside the discrete location, the dose of capsaicin ranging from 1 μg to 3000 μg.

Chronic pain is alleviated in a mammal suffering there from by administering to the mammal a chronic pain alleviating amount of a nontoxic N-methyl-D-aspartate receptor antagonist such as dextromethorphan, dextrorphan, ketamine or pharmaceutically acceptable salt thereof, in combination with a μ-opiate analgesic such as tramadol or an analogously acting molecular entity, and a capsaicin or an ester of capsaicin, and optionally in sustained release dosage form.

The present invention relates to the formulations of ester derivatives of capsaicin and ester derivatives of myristoleic acid. These derivatives are capable of reverting to the active parent compound following enzymatic or chemical hydrolysis. These derivatives have a higher lipophilicity, lipid solubility and less irritation to the skin than the parent compound, and hence are better able to be incorporated into certain pharmaceutical formulations, including cream and ointment pharmaceutical formulations. The pharmaceutical compositions of the present invention contain a compound of following formula (Ia):

R—CO-CAP   (Ia)

wherein CAP refers to collectively the capsaicins represented in FIG. 1 and a compound of formula (Ib):

MCO-O—R   (Ib)

wherein MCO refers to myristoleic acid.

In formulae Ia and Ib, R is selected from alkyl groups of up to about 18 carbon atoms and aryl groups of up to about 18 carbon atoms and alkylene group of up to about 18 carbon atoms and an arylene group of up to about 18 carbon atoms. The alkyl, aryl and alkylene groups may be substituted or un-substituted, branched or straight chains. In addition, R may contain heteroatoms and may be straight chained or branched.

The pharmaceutical compositions containing compounds of formulae Ia and Ib are useful for pain management in mammals in vivo and have been contemplated to be used in the treatment of various pains in humans.

Disclosed is a pain relief composition comprising an effective amount of a nerve inhibiting component, including capsaicin, a capsaicinoid or a capsaicin analogue, which numbs or inhibits the nerve endings that signal pain, in combination with at least one of the following: an effective amount of an inflammation control component which is designed to reduce immediate pain and discourage future pain in the joints and muscles; an effective amount of a cooling component; an effective amount of a heat minimizing or blocking component; an effective amount of a circulation increasing component which effectuates better penetration of the actives to the skin and nerves; and an effective amount of a soothing and anti-inflammatory complex for the joints and/or muscles comprising Glucosamine sulfate or HCl, Zingiber officiniale (Ginger Root) extract, Methyl sulfonylmethane (MSM), Polygonum cuspidatum (Mexican Bamboo) extract, Aloe barbadensis leaf, and Salix alba (white willow) bark extract. Additionally, the composition includes an encapsulation or entrapment system for a timed release delivery.

Methods of treatment in subjects suffering from diabetes mellitus or obesity are provided. The methods comprise the step of administering an active agent directly to the small intestine in the subject. In particular, the active agent may be administered directly to the duodenum in the subject. The active agents useful in the treatments described herein include analgesic agents and, in particular, antinociceptive agents such as capsaicin, resiniferatoxin, and their analogues.

The invention provides a plant source bacteriostasis and detoxification deodorant. The plant source bacteriostasis and detoxification deodorant is prepared by the following plant materials in parts by weight: 10-15 parts of tobacco stems, 12-20 parts of Ilex latifolia Thunb stems, 2-8 parts of Helianthus tuberosus Linn leaves, 5-15 parts of ginkgo biloba, 8-16 parts of capsaicin, 1-5 parts of tanshinone, 15-25 parts of orange peel, 2-8 parts of paeoniflorin, 1-5 parts of tea seed, 8-15 parts of ginger stems, 15-35 parts of wild chrysanthemum flower, 5-20 parts of garlic, 5-15 parts of ginger, 20-35 parts of sophora alopecuroides, 5-10 parts of pine needle oil, 15-30 parts of artemisia annua, 20-50 parts of green beans, 30-60 parts of barley and 20-35 parts of corn. The plant source bacteriostasis and detoxification deodorant provided by the invention has the advantages of high biological activity, strong broad-spectrum antibacterial property, fast insect and egg killing, good environment-friendly property, safety, high efficiency and the like. The invention also provides a preparation method and application of the plant source bacteriostasis and detoxification deodorant.

The invention provides a natural pigment composition. The natural pigment comprises an emulsifier and two or more than two pigments of gardenia yellow pigment, curcumin, carithamine, citroxanthin, xanthophyll, riboflavin, capsaicin, monascus red pigment, bixa orettana pigment and gardenia blue. Natural pigments can prepare natural pigment compositions in different color systems and different tones in arbitrary proportions, such as yellow, orange, red, green and purple. Meanwhile, the natural pigment composition contains the emulsifier, so that the composition can be more uniform and more stable. Therefore, in the natural pigment composition provided by the invention, combinations of different natural pigments can overcome the defect of single pigment, for example, the light resistance of natural yellow pigment combined by the riboflavin, the curcumin and the like with poor light resistance and the gardenia yellow pigment with more stable light resistance is better than that of the riboflavin or the curcumin, thus the dosage can be reduced, and the cost can be reduced.

Disclosed in certain embodiments is a method for relieving pain at a site in a human or animal in need thereof, comprising administering by injection or infiltration, a dose of a capsaicinoid and coadministering a vasodilator.

The present disclosure relates to a composition to enhance the bioavailability of curcumin. In one embodiment, a composition comprising plant extracts of curcumin, vanilla and ginger, wherein the extracts of ginger and vanilla are rich in gingerol and vanillin respectively, is provided. In other embodiments, curcumin, and one or more items selected from the group of vanilla, ginger and capsaicin is provided.

The invention relates to a new monofunctional acrylamide compound with a capsaicinoid functional structure and a preparation method and application thereof. The acrylamide compound has the chemical structural formula (I) in the specification, wherein in the formula, R1, R2, R3 or R4 represents alkyl, OH group, OCH3 and other substituent groups. The monofunctional acrylamide compound with the capsaicinoid functional structure contains not only a capsaicin important active group, but also active double-bonds capable of performing polymerization reaction, the synthesis method is simple and easy to operate, the yield is high, and the monofunctional acrylamide compound can make up for the defect that the mass production of natural capsaicin is limited by complicated extraction processes and the output of hot pepper and simultaneously make up for the insufficiency that the natural capsaicin can only be used as a pure additive. The monofunctional acrylamide compound with the capsaicinoid functional structure, provided by the invention, has very good application prospects in preparation of marine antifouling coatings or antibacterial and mildew-proof coatings.

The invention relates to a novel multifunctional acrylamide compound containing a capsaicin-like functional structure and a preparation method and an application thereof. The compound has the chemical structure shown in the formula (I) in the specification, wherein R1, R2 or R3 represents an alkyl group, an OH group or an OCH3 substituent group. The acrylamide compound disclosed by the invention contains an important capsaicin active group as well as an active double bond capable of carrying out polymerization reaction. The synthesis method is simple and feasible, and the yield is high. The shortcomings that the amount of the natural capsaicin is limited by the complex extraction process and the pepper yield and the natural capsaicin is only used as an additive are made up. The acrylamide compound disclosed by the invention has very good application prospect in preparing the marine antifouling paint or antibacterial and antifungal coating and the viscosity of the polymer can be significantly increased when the acrylamide compound is used as a crosslinking agent.

The invention discloses special red sour soup. The special red sour soup is prepared from the following components in parts by weight: 70-80 parts of fresh tomatoes, 15-25 of fresh chili pepper, 0.15-0.25 part of sticky rice, 0.1-0.2 part of ginger, 0.1-0.2 part of garlic, 1.5-3 parts of table salt, and 0.15-0.25 part of white spirit. Through improvements on the raw materials and the material ratio of the red sour soup, the fermented sour soup is rich in nutrients and contains nutritional ingredients such as VA, VB1, VB2, VC, Ca, P, Fe, carotene, capsaicin, cellulose and multiple amino acids, fermentation products and other nutritive substances in the sour soup enable the constitution of intestinal flora to have beneficial change and can improve gastrointestinal functions of a human body, recover flora balance in human intestinal tracts and form an antibacterial biological barrier to maintain human health, and meanwhile, the improved special red sour soup is easy to store and convenient to transport, thereby making the large-scale commercial production of the red sour soup possible.

The invention relates to a kind of capsicum alkali antifouling dope. Its materials weight proportions are: active acrylic resin 18-25%, calcareousness powderó±30-40%, calcareousness powderó�18-30%, calcium hydroxide 2-6%, capsicum alkali 0.05-0.10%, bentonite 9-14% and silica powder. It is a kind of antifouling dope which prevents sea biology from accreting with active acrylic resin as basic material, calcareousness powder and calcium hydroxide of different granularities, and capsicum alkali as driving agent. The quantity average molecular weight of active acrylic resin Mn = P800, the weight average weight Mw = 17100, and the dispersing intensity D = 1.75. Through seawater (pH = 7.5) simulating hanging board experimentation, the seeping rate of capsicum alkali of the dope stabilizes at 74 - 118 ª–gíñm-2d-1, its pH stabilizes at 9.5 - 10.0, and its effective antifouling period can get to over 3 years. The dope of the invention is non-toxic, highly effective, and low-cost.

This is a kind of acrylic zinc or cuprum resin containing capsaicin functional group and its preparation method. Its characteristics are: firstly synthesize monomer containing capsaicin functional group, then synthesize acrylic resin containing functional group and carboxyl, finally make the acrylic resin and zinc hydroxide or cuprum hydroxide react to obtain acrylic zinc or cuprum resin containing capsaicin functional group. The resin of the invention can be used for preparing sea antifouling dope. In the seawater, the organic zinc or cuprum acrylic ester on the polymer linear main chain of the coat surface hydrolyzes, and send out organic zinc or cuprum; the hydrolyzed polymer main chain contains capsaicin functional group with highly efficient antifouling activeness, which makes the hydrolyzed polymer main chain still has sterilization activeness. So the dope can effectively prevent halobios from clinging on the surface of fishing tools, ships and seacoast establishments, and has good antifouling performance.

The present invention relates to pharmaceutical compositions comprising ester(s) of capsaicin and at least one other agent selected from salicylates, menthol, boswellic acids, DMSO, methyl sulfonylmethane, NSAIDs, corticosteroids, emu oil, opioid agonists and antagonists, NMDA antagonists, tramadol, hyaluronic acid, α2δ ligands, santalol, santalyl acetate, amyris alcohol, amyris acetate, aloe vera gel and aloe vera juice, for improved therapeutic properties. Further, the present invention relates to pharmaceutical compositions comprising high concentrations of ester(s) of capsaicin. Further, the present invention relates to a method of relieving pain due to various diseases in subjects by administering the pharmaceutical compositions of the invention. Further, the present invention relates to methods of relieving fever blisters due to cold sores in subjects by administering the pharmaceutical compositions comprising an ester of capsaicin and one other agent selected from santalol, santalyl acetate, amyris alcohol and amyris acetate.

The invention discloses a seasoning processing technique for spicy capsaicin, comprising the following steps of: soaking: soaking textured soybean protein by cold water, wherein the temperature of cold water is 10-15 DEG C and the soaking time is 4-6hours; dehydrating: dehydrating the soaked textured soybean protein till the water content is 45-50%, wherein the dehydration mode is natural drying dehydration or mechanical centrifugal dehydration; frying: slicing the hydrated textured soybean protein to obtain original capsaicin, and frying by a continuous automatic fryer, wherein the frying temperature is controlled at 145-170 DEG C, and the frying time is 70s; blending: adding seasoning in the fried capsaicin and blending. By strictly controlling the technical parameters of the seasoning processing technique, the produced product is even in color and luster, good in taste, more delicious after seasoning of a special formula is added, and is safe and healthy to eat, and only a food additive disodium 5'-ribonucleotide is added.

The invention discloses a daily feed used for eupolyphoge sinensis culturing. The daily feed comprises a concentrated feed and a greenfeed. The concentrated feed is composed of following ingredients, by weight, 2 to 3 parts of yeast, 2 to 5 parts of beer yeast, 0.5 to 1 part of cane sugar, 65 to 75 parts of wheat bran, 5 to 7 parts of soya bean meal, 2 to 5 parts of concentrated soybean protein powder, 6 to 8 parts of corn powder, 0.02 to 0.04 part of ascorbic acid, 0.03 to 0.05 part of multivitamin, and 0.3 to 0.5 part of cellulose powder. The greenfeed is composed of following ingredients, by weight, 40 to 50 parts of pumpkin, 20 to 30 parts of black locust leaf, 10 to 20 parts of alniphyllum fortune, and 10 to 20 parts of Chinese cabbage. According to the daily feed, mixing feeding of the concentrated feed and the greenfeed is adopted, comprehensive nutritional demands of eupolyphoge sinensis are satisfied; yeast is added into the daily feed, so that dyspepsia of eupolyphoge sinensis is treated effectively, food consumption is increased, and eupolyphoge sinensis growth is promoted; appetite of eupolyphoge sinensis is promoted effectively by adding capsaicine into the daily feed at set intervals; and feed consumption of eupolyphoge sinensis is ensured.