107 results about "Capsaicin" patented technology

The invention discloses a preparation method and application of self-crosslinking hydrogel containing a capsaicin functional structure, and belongs to the technical field of dye adsorption materials. The capsaicin functional structure monomer is introduced into an acrylic acid system, so that the self-crosslinking of the hydrogel is realized, and meanwhile, the adsorption performance of the hydrogel is remarkably improved; mono-substituted capsaicin functional structure monomers containing carboxyl and sulfonic acid groups are used as components, a disubstituted capsaicin functional structure monomer with polyhydroxy and carboxyl is used as a cross-linking agent, the self-crosslinking hydrogel with multiple adsorption sites is successfully constructed through free radical polymerization, and the adsorption capacity and efficiency of the hydrogel are greatly improved. The hydrogel-based carbon material is obtained by carbonizing the self-crosslinking hydrogel containing the capsaicin functional structure, the adsorption performance of the hydrogel material is further improved, the obtained hydrogel-based carbon material can be desorbed and recycled in ethyl alcohol, and the service life of the hydrogel-based carbon material is prolonged. And the problem of secondary pollution of the existing hydrogel material in the acid / alkali desorption process is effectively avoided.

The invention provides a composite acrylic acid low-surface-energy antifouling coating, a preparation method and application, and belongs to the technical field of marine antifouling materials, the composite acrylic acid low-surface-energy antifouling coating comprises a three-layer composite structure, the three-layer composite structure comprises a bottom layer, a middle layer and a surface layer from bottom to top, the bottom layer is capsaicin-loaded polymethyl methacrylate, and the middle layer is a polymethyl methacrylate surface layer. The bottom layer is made of capsaicin, the middle layer is made of pressure-sensitive adhesive activated by oxygen plasma, the surface layer is made of dihydroxyl-terminated polydimethylsiloxane, the mass ratio of the bottom layer to the middle layer to the surface layer is (23-25): 1: (23-25), and the mass content of capsaicin in the bottom layer accounts for 5.82-5.75% of the total mass; based on the bonding strength change of the pressure-sensitive adhesive generated by oxygen plasma jet and the capsaicin for effectively inhibiting biological growth, polyacrylic acid is used as a self-polishing reservoir to continuously release an environment-friendly antifouling agent; the pressure-sensitive adhesive adheres to the polydimethylsiloxane layer through the adhesive force change generated by oxygen plasma to achieve the low-surface-energy antifouling effect, synergistic gain is achieved, the composite material intervenes into the biological fouling process from multiple aspects, and the composite material copes with the marine biological fouling process jointly.

To provide protective clothing that can protect the body when attacked by a bear and repel the bear. [Solution] Protective clothing worn to repel bear attacks comprises a protective fabric 1 sandwiched between a surface fabric 2 and a backing fabric 3. The protective fabric 1 comprises a chemical-containing layer 11 capable of releasing a chemical to repel bears, and a protective layer 12 for physical protection from bear attacks. The chemical used to repel bears is capsaicin, derived from chili peppers. When a strong force is applied to the human body by a bear attack, physical damage to the chemical-containing layer 11 causes the chemical to be released, allowing the bear to repel. Furthermore, the protective layer 12 cushions the impact on the human body, making the garment effective in protecting the human body from bear attacks.

The invention discloses an application of a compound fresh bamboo juice in a guinea pig asthma model, and relates to the field of medicines, a Hartley albino guinea pig is adopted to construct an OVA induced asthma model, and the model is verified to be successfully constructed through evaluation indexes; evaluating the efficacy of the successfully constructed guinea pig asthma model by using different doses of compound fresh bamboo juice, and evaluating the efficacy of the guinea pig asthma model by scoring guinea pig capsaicin stimulation cough inducing times, alveolar lavage fluid leukocyte number, inflammatory factor content, lung tissue hydroxyproline content and behavioral signs. And evaluating the treatment effect of the compound fresh bamboo juice through Western blot detection, lung histopathology and immunofluorescence staining indexes. In a guinea pig asthma model, high-dose and medium-dose groups of the compound fresh bamboo juice can be used for remarkably reducing the number of cough, reducing the number of white blood cells in alveolar lavage fluid and the level of inflammatory factors and inhibiting pulmonary fibrosis, and a good treatment effect is shown. The results provide powerful support for potential application of the compound fresh bamboo juice in asthma treatment.

The application belongs to the technical field of marine functional polymer antifouling materials, and discloses an acrylic metal salt resin containing silicone and a capsaicin derivative structure, a preparation method and application thereof. The acrylic metal salt resin, silicone and a compound containing the capsaicin derivative structure are combined, the viscosity of the resin is synergistically controlled by using various functional acrylate monomers, the hydrophobic silicone chain segment is effectively integrated with the capsaicin derivative structure which has antibacterial activity and hydrophilic properties, a novel acrylic metal salt resin containing silicone and the capsaicin derivative structure is prepared, the resin has multifunctional antifouling properties such as hydrophilic / hydrophobic regulation, enhanced antibacterial activity and self-polishing renewal, the raw materials are low in price, and the obtained product has excellent antibacterial performance and more than 6 months of real sea antifouling capacity.

The invention discloses a capsaicin intercalated chlorite composite filler and an application thereof in an anticorrosive coating, and the method mainly comprises the following steps: peeling chlorite, preparing the composite filler from capsaicin intercalated chlorite, and mixing with other auxiliary materials according to a certain ratio to obtain the anticorrosive coating. The composite filler is applied to epoxy resin and other anticorrosive coatings, chlorite lamellas provide a physical barrier, capsaicin is controllably and slowly released from the interlayer, and the coating is endowed with long-acting and intelligent active anticorrosive ability through a'physical shielding-chemical slow release-biological bacteriostasis' triple synergistic mechanism.

The invention provides biological nano composite hydrogel as well as a preparation method and application thereof, and the preparation method of the biological nano composite hydrogel comprises the following steps: dissolving VVPS and beta-CD in a NaOH aqueous solution, heating to 60-63 DEG C, and stirring for more than 30 minutes until the VVPS and the beta-CD are completely dissolved; slowly adding PEGDGE into the solution, continuously stirring until the cross-linking agent is dissolved, raising the temperature to 65 DEG C or above, and reacting for 4 hours or above to form hydrogel; and performing swelling treatment on the hydrogel, drying, soaking in an ethanol water solution containing capsaicin for more than 48 hours, filtering, and performing freeze drying. The biological nano composite hydrogel prepared by the preparation method disclosed by the invention has good application in delivery of capsaicin and alleviation of type II diabetes mellitus.

The present invention relates to a pharmaceutical composition comprising a pharmaceutically acceptable vehicle and non-pungent derivatives of capsaicin, in their tautomeric forms and pharmaceutically acceptable salts, as the sole active ingredient, for use in the stimulation of the sphenopalatine ganglion and the enhancement of cerebral blood flow, to prevent or reduce brain injury resulting from decreased cerebral blood flow. The composition is administered via the oral transmucosal route, preferably in the form of a mucoadhesive tablet, and may be formulated for immediate or prolonged release, ensuring effective and tolerable absorption while avoiding the irritant effects associated with pungent capsaicin.

The present application relates to a kind of electrochemical detection method and system for capsaicin, detection method includes: providing three electrode system;Configuration electrolyte solution and dissolve capsaicin standard sample or sample to be measured;Electrochemical detection is carried out using three electrode system to obtain oxidation peak current signal;Based on the corresponding relationship between oxidation peak current and capsaicin concentration determines the capsaicin content in sample to be measured.Detection system includes three electrode system, battery module, power module, MCU module, electrochemical detection circuit, signal conditioning circuit and communication module, can realize the rapid, sensitive detection of capsaicin.The present application improves the detection sensitivity by carbon nanocomposite modified carbon cloth electrode, combined with portable hardware circuit design, get rid of the dependence on large instrument, applicable to the on-site rapid detection of capsaicin in food industry, provide scientific, objective technical means for hot degree quantification.

This invention relates to the field of cables, and more particularly to a flexible, wear-resistant, low-voltage cable, comprising: several conductive cores, each conductive core being covered with an insulating layer, the insulating layer being covered with an inner sheath, several annular mounting blocks, the annular mounting blocks being linearly arrayed and fixedly connected to the outer sheath, the outer sheath being fixedly connected to the outer wall of each annular mounting block, and several micro-capsule grooves arrayed within the outer sheath. This invention utilizes a first microcapsule and a second microcapsule. The first microcapsule contains capsaicin solution and other rodent-repellent active ingredients within its wall, while the second microcapsule contains epoxy resin prepolymer and other self-healing agents within its wall. Both are uniformly mixed and distributed within the micro-capsule grooves. When the outer sheath is damaged by rodents or insects, both microcapsules rupture simultaneously. The capsaicin solution immediately repels the injuring rodents and insects, while the epoxy resin prepolymer flows out and undergoes a curing reaction, filling and sealing the damaged area.

This invention relates to the field of medicinal chemistry, specifically to a capsaicin-like compound containing isopropanolamine, its preparation method, and its application. This type of compound has a structure as shown in general formula (I). The invention uses capsaicin and isopropanolamine as pharmacophores, connecting the two pharmacophores with different bridging chains to synthesize a series of capsaicin-like derivatives containing isopropanolamine. These compounds exhibit excellent inhibitory effects on plant pathogenic bacteria such as rice bacterial blight, citrus canker, rice bacterial leaf streak, and kiwifruit canker; and plant pathogenic fungi such as cucumber gray mold, pepper wilt, rapeseed sclerotinia rot, eggplant verticillium wilt, wheat scab, potato late blight, blueberry root rot, grape coccidioidomyces, dragon fruit anthracnose, and rice sheath blight, providing an important scientific basis for the research and development of new pesticides.

A metal-capsaicinoid complex that renders the capsaicinoid water-soluble is disclosed along with related compositions. Methods of producing the metal-capsaicinoid complex are also disclosed.

The invention discloses a synthetic capsaicin microcapsule sustained-release seed coating agent as well as a preparation method and application thereof, and belongs to the technical field of agricultural chemistry. The preparation method of the synthetic capsaicin microcapsule sustained-release seed coating comprises the following steps: dissolving synthetic capsaicin in a cyclohexanone solvent, adding diisocyanate dicyclohexylmethane, and mixing to obtain an oil phase; adding OP-10 into the tea saponin extracting solution, and performing ultrasonic dissolution to obtain a water phase; adding the water phase into the oil phase, stirring and shearing; adding dibutyltin dilaurate into the sheared solution, and reacting in a dark place to obtain a synthesized capsaicin microcapsule; and adding an auxiliary agent acceptable to the seed coating agent into the synthesized capsaicin microcapsule to obtain the synthesized capsaicin microcapsule sustained-release seed coating agent. The synthesized capsaicin microcapsule slow-release seed coating agent has efficient bird repelling activity, environmental friendliness and slow-release characteristics, continuous repelling from the sowing stage to the seedling stage is achieved, and meanwhile the influence on non-target organisms is reduced.

The present application provides a polypeptide composition with anti-obesity effect, which is composed of capsaicin and polypeptides, and the amino acid sequence of the polypeptides comprises any one or more of SEQ ID NO. 1 to SEQ ID NO. 8. The polypeptides of sequences 1-8 are mixed uniformly at a mass ratio of 1-20:1-4:1-2:1-4:1:1:1:1, and the capsaicin is mixed with the mixed polypeptides at a ratio of 2-12:100 (w / w). The polypeptide composition proposed in the present application, in combination with capsaicin, not only promotes the weight loss effect of capsaicin, but also significantly reduces the fat index of the test mice after use, and can significantly reduce the total cholesterol concentration in the liver and the liver triglyceride concentration under a high-fat diet.

The invention belongs to the technical field of food processing and medicine preparation, and particularly relates to a uric acid reducing composition and a preparation and application thereof. According to the invention, the functional active components capsaicin and quercitrin in hot pepper are found for the first time and both have prevention and improvement effects on hyperuricemia. The two medicines can inhibit activity of purine metabolism key enzyme, promote excretion of uric acid, reduce oxidative stress and inflammatory factor level of a body, delay pathological process of hyperuricemia and protect liver and kidney functions, and do not cause liver and kidney injury and other side effects after long-term use. Moreover, the uric acid reducing effect of cooperative intervention of the capsaicin and the quercitrin, the improvement effect on hyperuricemia and the molecular mechanism of the hyperuricemia are clarified from multiple aspects, and it is proved that the capsaicin and the quercitrin are compounded according to a certain proportion to achieve synergistic interaction. Capsaicin and quercitrin are taken as active ingredients and can be used for developing health care products and medicines with the uric acid reducing effect.

The invention relates to the field of cosmetics, in particular to a compound and application thereof. The inventor creatively discovers that the compound with the structure shown in the formula I has the effect of inhibiting melanocytes and tyrosinase, and proves that the compound has new application in whitening and has application in preparation of whitening products. Experiments show. The compound with the structure shown in the formula I is superior to the traditional capsaicin with a whitening effect in the inhibition effect on melanocytes and tyrosinase.

A smoke producing method and device of the present disclosure produces a non-incendiary, organic-polymerization based, smoke-producing reaction. Some versions of the smoke are effective carriers for capsaicinoid compounds. The method of generating smoke comprises initiating a frontal polymerization reaction by heating a composition comprising a monomer compound that exothermically polymerizes upon initiation with an initiator compound and an initiator compound that initiates polymerization of the monomer compound present at a mass concentration that is at least five percent of the mass concentration of the monomer compound. The polymerization of the monomer compound is exothermic, and in one embodiment the concentration of initiator compound is at least five percent of the concentration of monomer compound. The smoke mainly comprises thermal decomposition products of the initiator compound.

The invention discloses application of a nutritional composition containing alpha-hydroxyisocaproic acid in weight management and blood fat improvement, and belongs to the fields of biological medicine manufacturing, biological medicine application and functional food development. The nutritional composition comprises alpha-hydroxyisocaproic acid and at least one second functional nutritional component, and the second functional nutritional component is preferably selected from one or more of the following components: 1) one or more of tea polyphenol and capsaicin; 2) one or more of beta-glucan, inulin and resistant dextrin; 3) one or more of medium chain triglyceride and sn-1, 3 diglyceride; under the condition of the same intake cycle and dosage, the nutritional composition can significantly improve the weight management effect and reduce related indexes of blood fat through a multi-way synergistic effect, and is combined with GLP-1 drugs or sequentially applied to weight management so as to reduce the risk of weight rise after drug withdrawal.

Pain relief compositions are described for topical application to penetrate deep into the skin, muscles, and joints. The pain relief compositions are prepared as creams for topical applying to the skin. The pain relief compositions contain active ingredients such as DMSO, capsaicin, menthol, eucalyptus extract, chamomile oil, methyl salicylate, and cayenne oil. One or more of the active ingredients is included in the pain relief composition as nanoparticles. Methods for preparing and for using the pain relief compositions are also described.

The invention discloses a rubber composite material with marine antifouling property as well as a preparation method and application thereof, and relates to the technical field of marine fouling organism decay protection materials. The rubber composite material with the marine antifouling property comprises the following components which are blended and vulcanized: rubber, a filler, an antifouling agent, a plasticizer, an activating agent, a scorch retarder, an anti-aging agent, an accelerant and a vulcanizing agent, the antifouling agent comprises a copolymer modified by zwitter-ions and at least one of sodium benzoate, tannic acid, 6-gingerol, capsaicin, sulfobetaine, carboxylic acid betaine, phosphorylcholine, isothiazolinone and zinc pyrithione optionally selected from the group consisting of sodium benzoate, tannic acid, 6-gingerol, capsaicin, sulfobetaine, carboxylic acid betaine, phosphorylcholine, isothiazolinone and zinc pyrithione. The invention solves the three core problems of poor compatibility of an antifouling agent and a rubber matrix, short antifouling period caused by easy loss of the antifouling agent, and difficulty in balancing the antifouling property and mechanical property in the existing marine antifouling rubber material.

The invention discloses low-temperature injectable hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. Hydrogel is prepared from high-molecular-weight hyaluronic acid grafted with vitamin E and poly (N-isopropylacrylamide), the hydrogel is in an injectable liquid state at 4 DEG C, and a drug capsaicin (CPZ) wrapped by micelle is loaded and injected into the brain from the brain in a stereotactic mode. The pharmaceutical composition can temporarily maintain local low temperature of brain tissue and release capsaicin, reduce local metabolic activity of ischemic brain tissue, temporarily inhibit biogenesis, reduce NADH, FADH2 and other reducing equivalents and ADP accumulation, reduce the possibility of electron leakage in an electron transport chain, and improve the bioavailability of ischemic brain tissue. Vitamin E is added to reduce superoxide anions (O2 <.->) generated by reduction reaction of oxygen and leaked electrons in the reperfusion process, and vitamin E can promote ROS removal, synergistically alleviate oxidative stress and subsequent inflammation, and comprehensively improve cerebral ischemia reperfusion injury.

The application relates to the field of capsaicin extraction, in particular to a natural capsaicin extraction method, which comprises the following steps: S1, qualified dry chillies are conveyed and torn into pieces through a chilli crusher; S2, the chilli pieces are continuously, quantitatively and airtightly conveyed to a countercurrent extractor set through a conveying auger, meanwhile, ethanol is added, the concentration of the ethanol is 70%, and continuous countercurrent extraction is carried out at a certain temperature, the temperature is 50 DEG C; the filtrate is filtered through a drum filter and a plate filter to obtain clean extraction liquid, and the extraction liquid is pumped into an extraction liquid clean liquid tank. The chilli pieces are airtightly conveyed through the countercurrent extractor set, so that the capsaicin is kept in a sealed environment, when the capsaicin extraction efficiency is improved by heating the ethanol in the later stage, the sealed environment can effectively reduce the direct leakage of the volatilized ethanol, reduce the waste of the ethanol, and the volatilized alcohol is recycled through hot steam in the later stage.

To provide an animal-repelling resin composition capable of realizing an animal-repelling article which has a low load on the environment, is easy to handle, has a long effective life, and to which an object animal is hardly adapted.SOLUTION: An animal repellent resin composition comprising a thermoplastic resin, and sustained-release inorganic particles and an animal repellent dispersed in the thermoplastic resin, wherein the thermoplastic resin has a softening point of 50 to 120 °C, the sustained-release inorganic particles are at least one selected from the group consisting of fly ash, activated clay, inorganic pigment, silica, and char, and the animal repellent is at least one selected from the group consisting of wood tar, 2, 6-dimethylpyrazine, 3-ethyl-2, 5-dimethylpyrazine, 2,3,5, - trimethylpyrazine, 2,4,5, - trimethylthiazole, garlic oil, and capsaicin-containing oil.SELECTED DRAWING: None

This invention belongs to the field of aquaculture technology and relates to a novel use of capsaicin, particularly its use in the preparation of drugs and / or feed additives for the prevention and treatment of fish viral infections. The core of this invention lies in the significant protective effect of capsaicin against carp spring viremia virus (SVCV), grass carp reovirus (GCRV), and carp herpesvirus type 2 (CyHV-2) infections, effectively inhibiting the transcription of SVCV, GCRV, and CyHV-2 viral genes and the expression of viral proteins. Feed additives and / or drugs containing capsaicin can be used for the prevention and treatment of fish viral diseases, offering advantages such as high protective efficiency and environmental friendliness.

Disclosed herein are solid forms containing a compound of formula (I):a solvate, hydrate or isotope thereof, wherein the solid form is characterized by an X-ray powder diffraction pattern having at least one peak position, in degrees 2θ (±0.2°), selected from 5.48, 13.74, 19.22 and 20.06. Also disclosed herein are related pharmaceutical compositions and methods of treatment.

The invention discloses a capsaicin derivative modified epoxy resin fluorescent coating which is prepared by taking a capsaicin amide derivative as a functional curing agent and taking a polyether amine curing agent and epoxy resin as raw materials through heating and curing. The fluorescent coating shows enhanced mechanical properties and adhesive force, emits bright indigo fluorescent light under excitation of 365 nm ultraviolet light, and has an early self-warning function on metal corrosion. The fluorescent coating has a wide application prospect in intelligent anti-corrosion monitoring in the fields of major infrastructures, ships, chemical equipment and the like.

This invention proposes a high-strength, high-toughness, low-smoke, halogen-free, flame-retardant, and rodent-proof cable sheath material and its preparation method. The raw materials for this cable sheath material include 80.0–100.0 parts of a polymer matrix, 80.0–100.0 parts of an inorganic flame retardant, a functional biomass rodent repellent, 2.0–4.0 parts of a vulcanizing agent, and 0.5–1.0 parts of a vulcanization accelerator. The functional biomass rodent repellent is prepared by a one-pot method using bio-based diol, bio-based diisocyanate, and capsaicin. The cable sheath material is obtained by adding the raw materials in proportion to an extruder for melting, blending, and extrusion, followed by cooling, curing, traction, pelletizing, and drying. The cable sheath material obtained by this invention possesses high strength, high toughness, high flame retardancy, and long-lasting rodent-proof properties, meeting the needs of the cable industry for materials with high mechanical properties, flame retardant performance, and long-lasting rodent-proof properties.

The invention discloses a construction method of a sensitive skin animal model, and belongs to the technical field of animal model construction. According to the method disclosed by the invention, the sensitive skin animal model is constructed by smearing the lauryl sodium sulfate on the back skin of the mouse after hair removal in combination with veratrine or capsaicin, so that physiological indexes of human sensitive skin can be simulated; key pathological processes of human sensitive skin can be simulated by detecting key pathological indexes such as skin barrier damage, nerve and blood vessel high reactivity, immune inflammation and the like, natural pathophysiological processes of human sensitive skin can be simulated, and pathogenesis of sensitive skin is basically covered; barrier destruction of mouse skin, high reactivity of nerve and blood vessels and inflammatory response are induced, and clinical practice is met. In addition, the method is good in repeatability, high in safety and easy and convenient to operate, sensitive skin medicine screening and personalized treatment scheme development can be promoted, the research and development period of sensitive skin related treatment schemes is shortened, and the application prospect is good.

The application discloses a preparation method and weight-reducing application of a fluorescent carbon quantum dot composition for targeting lipid droplets. Capsaicin and o-phenylenediamine are weighed and added into anhydrous ethanol, ultrasonic dissolution is carried out to obtain a solution with a concentration of 0.02-0.06 g / ml, the solution is added into an inner container of a high-pressure reaction kettle, and the high-pressure reaction kettle is heated at 160-200 DEG C for 10-14 hours and then cooled to room temperature; after filtration, the solution is dialyzed for 46-50 hours, freeze-dried to obtain a powder, and the powder is stored at 3-5 DEG C, so as to obtain the fluorescent carbon quantum dot composition; the method has easy raw materials and simple process; the carbon quantum dot composition has good biocompatibility, has no any toxicity to animals or human bodies, can target lipid droplets in mature adipocytes and display green fluorescence; the carbon quantum dot can be applied to preparation of medicines for treating obesity diseases, and the weight-reducing effect is remarkable, and the weight of high-fat diet mice can be reduced by about 16% in three weeks; the fluorescent properties of the fluorescent carbon quantum dot itself can also play a role in monitoring the residual amount of the medicine.