185 results about "Capsaicin" patented technology

The invention discloses a preparation method and application of self-crosslinking hydrogel containing a capsaicin functional structure, and belongs to the technical field of dye adsorption materials. The capsaicin functional structure monomer is introduced into an acrylic acid system, so that the self-crosslinking of the hydrogel is realized, and meanwhile, the adsorption performance of the hydrogel is remarkably improved; mono-substituted capsaicin functional structure monomers containing carboxyl and sulfonic acid groups are used as components, a disubstituted capsaicin functional structure monomer with polyhydroxy and carboxyl is used as a cross-linking agent, the self-crosslinking hydrogel with multiple adsorption sites is successfully constructed through free radical polymerization, and the adsorption capacity and efficiency of the hydrogel are greatly improved. The hydrogel-based carbon material is obtained by carbonizing the self-crosslinking hydrogel containing the capsaicin functional structure, the adsorption performance of the hydrogel material is further improved, the obtained hydrogel-based carbon material can be desorbed and recycled in ethyl alcohol, and the service life of the hydrogel-based carbon material is prolonged. And the problem of secondary pollution of the existing hydrogel material in the acid / alkali desorption process is effectively avoided.

The invention relates to the technical field of power cables, and discloses a manufacturing process of a flame-retardant anti-rat-bite cable, which comprises the following steps: step S1, mixing and granulating in an inert atmosphere; step S2, conductor pretreatment; step S3, carrying out multi-layer co-extrusion coating; s4, gradient cooling and interface strengthening are carried out, and the co-extruded cable passes through a three-section type cooling tank in sequence to be cooled; and after cooling, carrying out electron beam irradiation crosslinking treatment on the cable immediately. The cable comprises a flame-retardant sheath layer, a long-acting rat-bite-proof layer, an insulating layer and a conductor from outside to inside. According to the invention, capsaicin is coated in a gelatin-Arabic gum composite capsule wall through a microencapsulation technology to form a physical isolation barrier, and the structure effectively prevents the contact between the repellent and the external environment, so that even in high-temperature mixing and long-term use, volatile components can be prevented from escaping, and the slow release period of the effective components is ensured to cover the design life of the cable.

The invention discloses application of capsaicin to resistance of grass carp to hypoxia stress, and belongs to the technical field of agricultural cultivation. Aiming at the problems of red blood cell function damage, liver and gill tissue damage and the like of grass carps under hypoxia stress, a trace amount of capsaicin is added into the grass carp feed, so that the feed formula is optimized, the reduction of red blood cell quantity and brittleness increase of grass carps in the later growth period caused by hypoxia stress are relieved, liver damage is relieved, and the growth period of grass carps is prolonged. The death rate of the grass carp in a low-oxygen environment is reduced, the culture risk is reduced, and the method has the characteristics of being green, safe, low in cost and remarkable in economic benefit and is suitable for large-scale grass carp culture industry.

The invention provides a composite acrylic acid low-surface-energy antifouling coating, a preparation method and application, and belongs to the technical field of marine antifouling materials, the composite acrylic acid low-surface-energy antifouling coating comprises a three-layer composite structure, the three-layer composite structure comprises a bottom layer, a middle layer and a surface layer from bottom to top, the bottom layer is capsaicin-loaded polymethyl methacrylate, and the middle layer is a polymethyl methacrylate surface layer. The bottom layer is made of capsaicin, the middle layer is made of pressure-sensitive adhesive activated by oxygen plasma, the surface layer is made of dihydroxyl-terminated polydimethylsiloxane, the mass ratio of the bottom layer to the middle layer to the surface layer is (23-25): 1: (23-25), and the mass content of capsaicin in the bottom layer accounts for 5.82-5.75% of the total mass; based on the bonding strength change of the pressure-sensitive adhesive generated by oxygen plasma jet and the capsaicin for effectively inhibiting biological growth, polyacrylic acid is used as a self-polishing reservoir to continuously release an environment-friendly antifouling agent; the pressure-sensitive adhesive adheres to the polydimethylsiloxane layer through the adhesive force change generated by oxygen plasma to achieve the low-surface-energy antifouling effect, synergistic gain is achieved, the composite material intervenes into the biological fouling process from multiple aspects, and the composite material copes with the marine biological fouling process jointly.

The invention provides a composition with an analgesic effect. The composition is an external medicament prepared from the following raw material medicines in parts by weight: 10-16 parts of teasel root, 2-4 parts of dragon's blood, 8-12 parts of safflower, 9-15 parts of myrrh, 9-15 parts of ligusticum wallichii, 9-15 parts of notopterygium root, 8-12 parts of clove, 8-12 parts of beautiful sweetgum fruit, 0.6-1 part of pepper, 2-4 parts of lucid ganoderma, 0.4-0.8 part of capsaicin and 0.08-0.12 part of musk. The invention also provides a preparation method and application of the composition. The traditional Chinese medicine composition is precise and appropriate in raw material formula compatibility, is used for treating pain, is clear and controllable in medicine effect, and provides a new choice for clinic.

To provide protective clothing that can protect the body when attacked by a bear and repel the bear. [Solution] Protective clothing worn to repel bear attacks comprises a protective fabric 1 sandwiched between a surface fabric 2 and a backing fabric 3. The protective fabric 1 comprises a chemical-containing layer 11 capable of releasing a chemical to repel bears, and a protective layer 12 for physical protection from bear attacks. The chemical used to repel bears is capsaicin, derived from chili peppers. When a strong force is applied to the human body by a bear attack, physical damage to the chemical-containing layer 11 causes the chemical to be released, allowing the bear to repel. Furthermore, the protective layer 12 cushions the impact on the human body, making the garment effective in protecting the human body from bear attacks.

The invention discloses a preparation method of a health-care medicinal patch capable of dispelling wind and eliminating dampness. According to the invention, a multi-dimensional synergistic effect is realized through organic fusion of a traditional Chinese medicine theory and a modern preparation technology. The monarch drug notopterygium root and radix clematidis play the main effects of dispelling wind and eliminating dampness, and the monarch drug notopterygium root and radix clematidis are matched with a collateral dredging network formed by radix angelicae pubescentis and ligusticum wallichii, so that joint cold-dampness retardation can be deeply relieved; local microcirculation can be activated by the meridian warming characteristic of the cassia twig and the folium artemisiae argyi, and penetration of the medicine effect to deep tissues is enhanced by the bidirectional penetration effect of the lycopodium clavatum and the garden balsam stem. The innovatively introduced capsaicin and clove oil form alternate cold and hot stimulation, so that angiotelectasis is promoted, drug absorption is accelerated, hot burning discomfort of a traditional plaster is relieved through the cooling effect, balanced improvement of treatment comfort is achieved, gradient release of drug components is achieved through the three technologies of nano-powder drug loading, microcapsule controlled release and gel slow release, and the curative effect is improved. And the treatment effect is improved.

The invention discloses a cable sheath master batch capable of preventing rodent of rats and ants and a preparation method of the cable sheath master batch. The cable sheath master batch comprises the following raw materials: 50-70 parts of a modified polyolefin matrix, 10-15 parts of a nano composite filler, 15-25 parts of a slow-release type composition capable of preventing rats and ants and 5-8 parts of a multifunctional additive system, the modified polyolefin matrix is prepared from 40 to 50 parts of polypropylene, 15 to 25 parts of polyethylene and 5 to 10 parts of ethylene propylene diene monomer; the nano composite filler is prepared from 3 to 5 parts of nano titanium dioxide, 3 to 5 parts of nano zinc oxide and 2 to 5 parts of graphene; the multifunctional additive system consists of 2-3 parts of a coupling agent, 1-2 parts of a composite antioxidant and 2-3 parts of an environment-friendly plasticizer. Natural substances such as capsaicin and menthol are compounded to serve as a core repellent, long-acting protection of 18 months or above can be achieved in combination with a chitosan-sodium alginate composite microcapsule slow-release carrier, rats and ants are not prone to generating drug resistance, and the rat and ant prevention time is prolonged by 2-3 times compared with a traditional chemical agent.

The present invention relates to a medical patch for the administration of capsaicin, such as a medical patch for use in methods of treatment, comprising an active agent-containing layer structure comprising capsaicin, and a method of making such a medical patch.

The invention discloses an application of a compound fresh bamboo juice in a guinea pig asthma model, and relates to the field of medicines, a Hartley albino guinea pig is adopted to construct an OVA induced asthma model, and the model is verified to be successfully constructed through evaluation indexes; evaluating the efficacy of the successfully constructed guinea pig asthma model by using different doses of compound fresh bamboo juice, and evaluating the efficacy of the guinea pig asthma model by scoring guinea pig capsaicin stimulation cough inducing times, alveolar lavage fluid leukocyte number, inflammatory factor content, lung tissue hydroxyproline content and behavioral signs. And evaluating the treatment effect of the compound fresh bamboo juice through Western blot detection, lung histopathology and immunofluorescence staining indexes. In a guinea pig asthma model, high-dose and medium-dose groups of the compound fresh bamboo juice can be used for remarkably reducing the number of cough, reducing the number of white blood cells in alveolar lavage fluid and the level of inflammatory factors and inhibiting pulmonary fibrosis, and a good treatment effect is shown. The results provide powerful support for potential application of the compound fresh bamboo juice in asthma treatment.

The application belongs to the technical field of marine functional polymer antifouling materials, and discloses an acrylic metal salt resin containing silicone and a capsaicin derivative structure, a preparation method and application thereof. The acrylic metal salt resin, silicone and a compound containing the capsaicin derivative structure are combined, the viscosity of the resin is synergistically controlled by using various functional acrylate monomers, the hydrophobic silicone chain segment is effectively integrated with the capsaicin derivative structure which has antibacterial activity and hydrophilic properties, a novel acrylic metal salt resin containing silicone and the capsaicin derivative structure is prepared, the resin has multifunctional antifouling properties such as hydrophilic / hydrophobic regulation, enhanced antibacterial activity and self-polishing renewal, the raw materials are low in price, and the obtained product has excellent antibacterial performance and more than 6 months of real sea antifouling capacity.

The invention discloses a capsaicin intercalated chlorite composite filler and an application thereof in an anticorrosive coating, and the method mainly comprises the following steps: peeling chlorite, preparing the composite filler from capsaicin intercalated chlorite, and mixing with other auxiliary materials according to a certain ratio to obtain the anticorrosive coating. The composite filler is applied to epoxy resin and other anticorrosive coatings, chlorite lamellas provide a physical barrier, capsaicin is controllably and slowly released from the interlayer, and the coating is endowed with long-acting and intelligent active anticorrosive ability through a'physical shielding-chemical slow release-biological bacteriostasis' triple synergistic mechanism.

The invention provides biological nano composite hydrogel as well as a preparation method and application thereof, and the preparation method of the biological nano composite hydrogel comprises the following steps: dissolving VVPS and beta-CD in a NaOH aqueous solution, heating to 60-63 DEG C, and stirring for more than 30 minutes until the VVPS and the beta-CD are completely dissolved; slowly adding PEGDGE into the solution, continuously stirring until the cross-linking agent is dissolved, raising the temperature to 65 DEG C or above, and reacting for 4 hours or above to form hydrogel; and performing swelling treatment on the hydrogel, drying, soaking in an ethanol water solution containing capsaicin for more than 48 hours, filtering, and performing freeze drying. The biological nano composite hydrogel prepared by the preparation method disclosed by the invention has good application in delivery of capsaicin and alleviation of type II diabetes mellitus.

The present invention relates to a pharmaceutical composition comprising a pharmaceutically acceptable vehicle and non-pungent derivatives of capsaicin, in their tautomeric forms and pharmaceutically acceptable salts, as the sole active ingredient, for use in the stimulation of the sphenopalatine ganglion and the enhancement of cerebral blood flow, to prevent or reduce brain injury resulting from decreased cerebral blood flow. The composition is administered via the oral transmucosal route, preferably in the form of a mucoadhesive tablet, and may be formulated for immediate or prolonged release, ensuring effective and tolerable absorption while avoiding the irritant effects associated with pungent capsaicin.

The present application relates to a kind of electrochemical detection method and system for capsaicin, detection method includes: providing three electrode system;Configuration electrolyte solution and dissolve capsaicin standard sample or sample to be measured;Electrochemical detection is carried out using three electrode system to obtain oxidation peak current signal;Based on the corresponding relationship between oxidation peak current and capsaicin concentration determines the capsaicin content in sample to be measured.Detection system includes three electrode system, battery module, power module, MCU module, electrochemical detection circuit, signal conditioning circuit and communication module, can realize the rapid, sensitive detection of capsaicin.The present application improves the detection sensitivity by carbon nanocomposite modified carbon cloth electrode, combined with portable hardware circuit design, get rid of the dependence on large instrument, applicable to the on-site rapid detection of capsaicin in food industry, provide scientific, objective technical means for hot degree quantification.

This invention belongs to the field of precision oncology diagnosis and treatment technology, specifically involving a nanomedicine delivery system with tumor microenvironment regulation capabilities, its preparation method, and its application. S1: An organic phase is prepared by dissolving ionizable lipids, helper phospholipids, cholesterol, and functionally modified lipids in a solvent at a molar ratio of 50:38.5:10:1.5. S2: Capsaicin is dissolved in the organic phase obtained in S1, and doxorubicin is dissolved in the solvent to prepare an aqueous phase. The organic and aqueous phases are rapidly mixed in a microfluidic device at a volume ratio of 3:1 to obtain a mixture. S3: The mixture obtained in S2 is placed in a dialysis bag and immersed in Tris buffer for magnetic stirring and dialysis, followed by concentration to obtain (C+D)@LNPPRT. This invention significantly enhances the precision detection of tumors, enables efficient early tumor detection and targeted chemotherapy, and improves treatment efficacy.

This invention relates to the field of cables, and more particularly to a flexible, wear-resistant, low-voltage cable, comprising: several conductive cores, each conductive core being covered with an insulating layer, the insulating layer being covered with an inner sheath, several annular mounting blocks, the annular mounting blocks being linearly arrayed and fixedly connected to the outer sheath, the outer sheath being fixedly connected to the outer wall of each annular mounting block, and several micro-capsule grooves arrayed within the outer sheath. This invention utilizes a first microcapsule and a second microcapsule. The first microcapsule contains capsaicin solution and other rodent-repellent active ingredients within its wall, while the second microcapsule contains epoxy resin prepolymer and other self-healing agents within its wall. Both are uniformly mixed and distributed within the micro-capsule grooves. When the outer sheath is damaged by rodents or insects, both microcapsules rupture simultaneously. The capsaicin solution immediately repels the injuring rodents and insects, while the epoxy resin prepolymer flows out and undergoes a curing reaction, filling and sealing the damaged area.

This invention relates to the field of medicinal chemistry, specifically to a capsaicin-like compound containing isopropanolamine, its preparation method, and its application. This type of compound has a structure as shown in general formula (I). The invention uses capsaicin and isopropanolamine as pharmacophores, connecting the two pharmacophores with different bridging chains to synthesize a series of capsaicin-like derivatives containing isopropanolamine. These compounds exhibit excellent inhibitory effects on plant pathogenic bacteria such as rice bacterial blight, citrus canker, rice bacterial leaf streak, and kiwifruit canker; and plant pathogenic fungi such as cucumber gray mold, pepper wilt, rapeseed sclerotinia rot, eggplant verticillium wilt, wheat scab, potato late blight, blueberry root rot, grape coccidioidomyces, dragon fruit anthracnose, and rice sheath blight, providing an important scientific basis for the research and development of new pesticides.

A metal-capsaicinoid complex that renders the capsaicinoid water-soluble is disclosed along with related compositions. Methods of producing the metal-capsaicinoid complex are also disclosed.

The invention relates to a nano-composite for promoting thermalization of cold tumors as well as a preparation method and application of the nano-composite. The nano-composite comprises capsaicin and graphene oxide. According to the invention, capsaicin is combined with graphene oxide, so that immunogenic cell death and active oxygen mediated pyroptosis can be promoted, and infiltration and activation of CD4 < + > and CD8 < + > T cells can be remarkably enhanced by the combined immunoreaction, so that potent anti-tumor immunoreaction is induced, and remarkable tumor inhibition is realized.

The invention belongs to the technical field of medicine, and discloses application of SHLP2 in preparation of medicine for relieving and treating acute and chronic inflammatory pain, and the amino acid sequence of SHLP2 polypeptide is MGVKFFTLSTRFFPSVQRAVPLWTNS. After the SHLP2 polypeptide is treated in an intrathecal (5 [mu] g / 10 [mu] g / 20 [mu] g) injection mode, the SHLP2 polypeptide shows a good treatment effect in an acute inflammation pain model induced by formalin and capsaicin and a chronic inflammation pain model induced by carrageenan and a complete Freund's adjuvant. The SHLP2 is utilized to target a mitochondrial genome, the effect of relieving acute and chronic inflammatory pain is achieved in a central sheath injection mode, and a target different from a traditional analgesic drug can be searched for treatment of the acute and chronic inflammatory pain.

The invention discloses a synthetic capsaicin microcapsule sustained-release seed coating agent as well as a preparation method and application thereof, and belongs to the technical field of agricultural chemistry. The preparation method of the synthetic capsaicin microcapsule sustained-release seed coating comprises the following steps: dissolving synthetic capsaicin in a cyclohexanone solvent, adding diisocyanate dicyclohexylmethane, and mixing to obtain an oil phase; adding OP-10 into the tea saponin extracting solution, and performing ultrasonic dissolution to obtain a water phase; adding the water phase into the oil phase, stirring and shearing; adding dibutyltin dilaurate into the sheared solution, and reacting in a dark place to obtain a synthesized capsaicin microcapsule; and adding an auxiliary agent acceptable to the seed coating agent into the synthesized capsaicin microcapsule to obtain the synthesized capsaicin microcapsule sustained-release seed coating agent. The synthesized capsaicin microcapsule slow-release seed coating agent has efficient bird repelling activity, environmental friendliness and slow-release characteristics, continuous repelling from the sowing stage to the seedling stage is achieved, and meanwhile the influence on non-target organisms is reduced.

The present application provides a polypeptide composition with anti-obesity effect, which is composed of capsaicin and polypeptides, and the amino acid sequence of the polypeptides comprises any one or more of SEQ ID NO. 1 to SEQ ID NO. 8. The polypeptides of sequences 1-8 are mixed uniformly at a mass ratio of 1-20:1-4:1-2:1-4:1:1:1:1, and the capsaicin is mixed with the mixed polypeptides at a ratio of 2-12:100 (w / w). The polypeptide composition proposed in the present application, in combination with capsaicin, not only promotes the weight loss effect of capsaicin, but also significantly reduces the fat index of the test mice after use, and can significantly reduce the total cholesterol concentration in the liver and the liver triglyceride concentration under a high-fat diet.

The invention belongs to the technical field of food processing and medicine preparation, and particularly relates to a uric acid reducing composition and a preparation and application thereof. According to the invention, the functional active components capsaicin and quercitrin in hot pepper are found for the first time and both have prevention and improvement effects on hyperuricemia. The two medicines can inhibit activity of purine metabolism key enzyme, promote excretion of uric acid, reduce oxidative stress and inflammatory factor level of a body, delay pathological process of hyperuricemia and protect liver and kidney functions, and do not cause liver and kidney injury and other side effects after long-term use. Moreover, the uric acid reducing effect of cooperative intervention of the capsaicin and the quercitrin, the improvement effect on hyperuricemia and the molecular mechanism of the hyperuricemia are clarified from multiple aspects, and it is proved that the capsaicin and the quercitrin are compounded according to a certain proportion to achieve synergistic interaction. Capsaicin and quercitrin are taken as active ingredients and can be used for developing health care products and medicines with the uric acid reducing effect.

The invention relates to the field of cosmetics, in particular to a compound and application thereof. The inventor creatively discovers that the compound with the structure shown in the formula I has the effect of inhibiting melanocytes and tyrosinase, and proves that the compound has new application in whitening and has application in preparation of whitening products. Experiments show. The compound with the structure shown in the formula I is superior to the traditional capsaicin with a whitening effect in the inhibition effect on melanocytes and tyrosinase.

The invention belongs to the technical field of capsaicin lacrimation agents, and particularly relates to a lacrimation agent with pure biological capsaicin as a base material and a preparation method of the lacrimation agent. Comprising the following components in percentage by volume: 1 to 10 percent of capsaicin extracting solution, 20 to 30 percent of ethanol solvent, 40 to 50 percent of isopropanol solvent, 5 to 10 percent of surfactant, 1 to 5 percent of antioxidant and 1 to 10 percent of flavoring agent. The lacrimation agent prepared by adding the ethanol, the isopropanol, the antioxidant and the surfactant has an excellent lacrimation effect and can be stably released when being applied to a high-speed lacrimation device, the lacrimation agent takes pure biological capsaicin as a base material, the components have small harm to a human body and are safer to use, and the stability of spray can be enhanced by adding the antioxidant, so that the spray has a good application prospect. And moreover, the surfactant is added in the preparation process, so that the irritation of the capsaicin can be relieved, and the fragrance is increased.

A smoke producing method and device of the present disclosure produces a non-incendiary, organic-polymerization based, smoke-producing reaction. Some versions of the smoke are effective carriers for capsaicinoid compounds. The method of generating smoke comprises initiating a frontal polymerization reaction by heating a composition comprising a monomer compound that exothermically polymerizes upon initiation with an initiator compound and an initiator compound that initiates polymerization of the monomer compound present at a mass concentration that is at least five percent of the mass concentration of the monomer compound. The polymerization of the monomer compound is exothermic, and in one embodiment the concentration of initiator compound is at least five percent of the concentration of monomer compound. The smoke mainly comprises thermal decomposition products of the initiator compound.

The invention discloses application of a nutritional composition containing alpha-hydroxyisocaproic acid in weight management and blood fat improvement, and belongs to the fields of biological medicine manufacturing, biological medicine application and functional food development. The nutritional composition comprises alpha-hydroxyisocaproic acid and at least one second functional nutritional component, and the second functional nutritional component is preferably selected from one or more of the following components: 1) one or more of tea polyphenol and capsaicin; 2) one or more of beta-glucan, inulin and resistant dextrin; 3) one or more of medium chain triglyceride and sn-1, 3 diglyceride; under the condition of the same intake cycle and dosage, the nutritional composition can significantly improve the weight management effect and reduce related indexes of blood fat through a multi-way synergistic effect, and is combined with GLP-1 drugs or sequentially applied to weight management so as to reduce the risk of weight rise after drug withdrawal.

The present invention belongs to the technical field of biomedicine, and specifically relates to a nociceptor skin organoid chip and its culture medium, construction method and application. A culture medium for a nociceptor skin organoid chip, the culture medium is composed of fetal bovine serum and the following components added to the fetal bovine serum: epidermal growth factor, bovine pituitary extract, Normocin, B27, nerve growth factor, insulin, hydrocortisone, human brain-derived neurotrophic factor and capsaicin. Using this culture medium to co-culture a skin chip with nociceptors to obtain a nociceptor skin organoid chip, which can be used for the verification of pain perception effects.