302 results about "Capsaicin" patented technology

The invention discloses a preparation method and application of self-crosslinking hydrogel containing a capsaicin functional structure, and belongs to the technical field of dye adsorption materials. The capsaicin functional structure monomer is introduced into an acrylic acid system, so that the self-crosslinking of the hydrogel is realized, and meanwhile, the adsorption performance of the hydrogel is remarkably improved; mono-substituted capsaicin functional structure monomers containing carboxyl and sulfonic acid groups are used as components, a disubstituted capsaicin functional structure monomer with polyhydroxy and carboxyl is used as a cross-linking agent, the self-crosslinking hydrogel with multiple adsorption sites is successfully constructed through free radical polymerization, and the adsorption capacity and efficiency of the hydrogel are greatly improved. The hydrogel-based carbon material is obtained by carbonizing the self-crosslinking hydrogel containing the capsaicin functional structure, the adsorption performance of the hydrogel material is further improved, the obtained hydrogel-based carbon material can be desorbed and recycled in ethyl alcohol, and the service life of the hydrogel-based carbon material is prolonged. And the problem of secondary pollution of the existing hydrogel material in the acid / alkali desorption process is effectively avoided.

The invention discloses an environment-friendly ant and rat-proof cable. The cable has an ant and rat-proof effect by adding azadirachtin, capsaicin and an auxiliary agent to a cable protective layer. The azadirachtin and capsaicin are natural plant extracts, which can be slowly released to achieve the effect of driving away rats and ants, and have no pollution to humans, livestock and the surrounding environment. The phenylthiourea structure in the auxiliary agent is a toxic rat and ant-repelling component, and has a wide range of antibacterial and bactericidal properties, and can prevent the cable from mildewing. The linked ethoxysilane structure can improve the adhesion of the auxiliary agent, avoid precipitation during use to cause cable performance degradation and environmental pollution, and can improve the dispersibility of the filler and improve the mechanical properties of the resin. The combustion of the silicon-oxygen structure in the auxiliary agent molecule can generate an inorganic oxygen-insulating and heat-insulating protective layer containing Si bonds and Si-C bonds, which can be flame-retardant and play a smoke-suppressing role. At the same time, the introduction of P and S elements can synergistically flame-retardant.

The invention belongs to the technical field of biosensing, and particularly relates to a cell electrochemical sensor and application thereof in evaluating the anti-inflammatory activity of capsaicin. Sb2O4 / rGO is firstly prepared, a DDAB-HIMIMPF6 composite material with stable current response and low biotoxicity is synthesized in one step, then the DDAB-HIMIMPF6 composite material is combined with the Sb2O4 / rGO, an electrochemical sensor is used for loading, and the cell electrochemical sensor with high selectivity and high sensitivity is finally obtained and can be applied to evaluation of the anti-inflammatory activity of capsaicin. Moreover, the cell electrochemical sensor provided by the invention not only can realize the purpose of evaluating the anti-inflammatory effect of capsaicin, but also has the outstanding advantages of low cost, high detection speed, simplicity in operation and miniaturization, and has a wide application prospect.

The invention relates to the technical field of power cables, and discloses a manufacturing process of a flame-retardant anti-rat-bite cable, which comprises the following steps: step S1, mixing and granulating in an inert atmosphere; step S2, conductor pretreatment; step S3, carrying out multi-layer co-extrusion coating; s4, gradient cooling and interface strengthening are carried out, and the co-extruded cable passes through a three-section type cooling tank in sequence to be cooled; and after cooling, carrying out electron beam irradiation crosslinking treatment on the cable immediately. The cable comprises a flame-retardant sheath layer, a long-acting rat-bite-proof layer, an insulating layer and a conductor from outside to inside. According to the invention, capsaicin is coated in a gelatin-Arabic gum composite capsule wall through a microencapsulation technology to form a physical isolation barrier, and the structure effectively prevents the contact between the repellent and the external environment, so that even in high-temperature mixing and long-term use, volatile components can be prevented from escaping, and the slow release period of the effective components is ensured to cover the design life of the cable.

The invention relates to the technical field of materials, and discloses a composite flame retardant as well as a preparation method and application thereof. Carrying out first reaction on the DOPO grafted silane coupling agent and capsaicin to obtain a first reaction product; and carrying out a second reaction on melamine, cyanuric acid and the first reaction product, and carrying out freeze drying and grinding on the obtained second reaction product to obtain the composite flame retardant. The composite flame retardant can be used for preparing a polypropylene composite material. According to the invention, ammonium polyphosphate, dipentaerythritol and a composite flame retardant are utilized to form a rat-bite-proof intumescent flame-retardant system, and the rat-bite-proof intumescent flame-retardant polypropylene composite material is prepared through melt blending; the oxygen index of the composite material can meet the flame-retardant requirement, the problem that molten drops severely drop during combustion is solved, meanwhile, the irritation influence of capsaicin in the material is reduced, and the polypropylene composite material is endowed with the non-toxic and non-lethal avoidance effect.

The utility model discloses an extraction device for capsaicin detection, which comprises an extraction cylinder, the top of the extraction cylinder is movably connected with a cylinder cover, the top of the cylinder cover is fixedly connected with a motor casing, and an inner cavity of the motor casing is fixedly connected with a driving motor frame through screws. By arranging the extraction cylinder, the cylinder cover, the motor shell, the driving motor, the hollow pipe, the crushing frame, the separation disc, the material blocking disc, the rotating rod, the chassis and the sealing disc, the driving motor is turned on, the output end of the driving motor drives the hollow pipe and the crushing frame on the surface of the hollow pipe to rotate, the rotating crushing frame crushes chilies, then the driving motor is turned off, the cylinder cover is taken down, and the chilies are extracted. A rotating rod is rotated by hand and drives a material blocking disc at the bottom of the rotating rod to rotate, along with rotation of the material blocking disc, a material leaking opening in the surface of a partition disc is exposed, the pepper mixed with the extracting solution falls into the top of a sealing disc, an electric push rod is opened, and a telescopic shaft of the electric push rod drives an extrusion plate to move to completely extrude juice in the pepper out.

The invention discloses application of capsaicin to resistance of grass carp to hypoxia stress, and belongs to the technical field of agricultural cultivation. Aiming at the problems of red blood cell function damage, liver and gill tissue damage and the like of grass carps under hypoxia stress, a trace amount of capsaicin is added into the grass carp feed, so that the feed formula is optimized, the reduction of red blood cell quantity and brittleness increase of grass carps in the later growth period caused by hypoxia stress are relieved, liver damage is relieved, and the growth period of grass carps is prolonged. The death rate of the grass carp in a low-oxygen environment is reduced, the culture risk is reduced, and the method has the characteristics of being green, safe, low in cost and remarkable in economic benefit and is suitable for large-scale grass carp culture industry.

The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.

The invention provides a composite acrylic acid low-surface-energy antifouling coating, a preparation method and application, and belongs to the technical field of marine antifouling materials, the composite acrylic acid low-surface-energy antifouling coating comprises a three-layer composite structure, the three-layer composite structure comprises a bottom layer, a middle layer and a surface layer from bottom to top, the bottom layer is capsaicin-loaded polymethyl methacrylate, and the middle layer is a polymethyl methacrylate surface layer. The bottom layer is made of capsaicin, the middle layer is made of pressure-sensitive adhesive activated by oxygen plasma, the surface layer is made of dihydroxyl-terminated polydimethylsiloxane, the mass ratio of the bottom layer to the middle layer to the surface layer is (23-25): 1: (23-25), and the mass content of capsaicin in the bottom layer accounts for 5.82-5.75% of the total mass; based on the bonding strength change of the pressure-sensitive adhesive generated by oxygen plasma jet and the capsaicin for effectively inhibiting biological growth, polyacrylic acid is used as a self-polishing reservoir to continuously release an environment-friendly antifouling agent; the pressure-sensitive adhesive adheres to the polydimethylsiloxane layer through the adhesive force change generated by oxygen plasma to achieve the low-surface-energy antifouling effect, synergistic gain is achieved, the composite material intervenes into the biological fouling process from multiple aspects, and the composite material copes with the marine biological fouling process jointly.

The invention belongs to the technical field of marine antifouling, and relates to a PE pipe coated with a capsaicin modified antifouling coating. The invention provides a PE pipe coated with a capsaicin modified antifouling coating, the PE pipe comprises a polyethylene matrix and an antifouling coating coated on the surface of the polyethylene matrix, the antifouling coating comprises waterproof paper printed with a capsaicin dot matrix and tung oil acid substances coated on the surface of the waterproof paper. The irritant capsaicin dot matrix is printed on the waterproof paper, the surface of the PE pipe is coated with the waterproof paper, then the surface of the waterproof paper is coated with the tung oil acid substances, the hydrophobicity of the surface of a coating and the cohesiveness of the coating and a PE base body are improved, and the effect of preventing marine organisms from adhering is achieved.

The invention provides a composition with an analgesic effect. The composition is an external medicament prepared from the following raw material medicines in parts by weight: 10-16 parts of teasel root, 2-4 parts of dragon's blood, 8-12 parts of safflower, 9-15 parts of myrrh, 9-15 parts of ligusticum wallichii, 9-15 parts of notopterygium root, 8-12 parts of clove, 8-12 parts of beautiful sweetgum fruit, 0.6-1 part of pepper, 2-4 parts of lucid ganoderma, 0.4-0.8 part of capsaicin and 0.08-0.12 part of musk. The invention also provides a preparation method and application of the composition. The traditional Chinese medicine composition is precise and appropriate in raw material formula compatibility, is used for treating pain, is clear and controllable in medicine effect, and provides a new choice for clinic.

To provide protective clothing that can protect the body when attacked by a bear and repel the bear. [Solution] Protective clothing worn to repel bear attacks comprises a protective fabric 1 sandwiched between a surface fabric 2 and a backing fabric 3. The protective fabric 1 comprises a chemical-containing layer 11 capable of releasing a chemical to repel bears, and a protective layer 12 for physical protection from bear attacks. The chemical used to repel bears is capsaicin, derived from chili peppers. When a strong force is applied to the human body by a bear attack, physical damage to the chemical-containing layer 11 causes the chemical to be released, allowing the bear to repel. Furthermore, the protective layer 12 cushions the impact on the human body, making the garment effective in protecting the human body from bear attacks.

The invention discloses a preparation method of a health-care medicinal patch capable of dispelling wind and eliminating dampness. According to the invention, a multi-dimensional synergistic effect is realized through organic fusion of a traditional Chinese medicine theory and a modern preparation technology. The monarch drug notopterygium root and radix clematidis play the main effects of dispelling wind and eliminating dampness, and the monarch drug notopterygium root and radix clematidis are matched with a collateral dredging network formed by radix angelicae pubescentis and ligusticum wallichii, so that joint cold-dampness retardation can be deeply relieved; local microcirculation can be activated by the meridian warming characteristic of the cassia twig and the folium artemisiae argyi, and penetration of the medicine effect to deep tissues is enhanced by the bidirectional penetration effect of the lycopodium clavatum and the garden balsam stem. The innovatively introduced capsaicin and clove oil form alternate cold and hot stimulation, so that angiotelectasis is promoted, drug absorption is accelerated, hot burning discomfort of a traditional plaster is relieved through the cooling effect, balanced improvement of treatment comfort is achieved, gradient release of drug components is achieved through the three technologies of nano-powder drug loading, microcapsule controlled release and gel slow release, and the curative effect is improved. And the treatment effect is improved.

The invention discloses a cable sheath master batch capable of preventing rodent of rats and ants and a preparation method of the cable sheath master batch. The cable sheath master batch comprises the following raw materials: 50-70 parts of a modified polyolefin matrix, 10-15 parts of a nano composite filler, 15-25 parts of a slow-release type composition capable of preventing rats and ants and 5-8 parts of a multifunctional additive system, the modified polyolefin matrix is prepared from 40 to 50 parts of polypropylene, 15 to 25 parts of polyethylene and 5 to 10 parts of ethylene propylene diene monomer; the nano composite filler is prepared from 3 to 5 parts of nano titanium dioxide, 3 to 5 parts of nano zinc oxide and 2 to 5 parts of graphene; the multifunctional additive system consists of 2-3 parts of a coupling agent, 1-2 parts of a composite antioxidant and 2-3 parts of an environment-friendly plasticizer. Natural substances such as capsaicin and menthol are compounded to serve as a core repellent, long-acting protection of 18 months or above can be achieved in combination with a chitosan-sodium alginate composite microcapsule slow-release carrier, rats and ants are not prone to generating drug resistance, and the rat and ant prevention time is prolonged by 2-3 times compared with a traditional chemical agent.

The invention discloses a capsaicin compound and a preparation method and application thereof, the molecular formula of capsaicin Capsivaryine is C16H21NO3, the chemical structure of capsaicin Capsivaryine is as follows, and the capsaicin Capsivaryine compound is a new compound reported for the first time and is prepared by taking mature and dry fruits of capsicum as raw materials through crushing, sieving, silica gel column treatment, D101 macroporous resin treatment and HPLC (High Performance Liquid Chromatography). The compound disclosed by the invention has a certain in-vitro inhibition effect on human breast cancer cells MCF-7, human liver cancer cells HEPG2, human non-small cell lung cancer cells A549 and human ovarian cancer cells SKOV3, and has no toxicity on human normal liver cells L02. The compound is a natural product which is novel in structure and good in activity, has great potential in the anti-tumor aspect, enriches diversity of pepper plants, and provides guidance for research of chemical components of pepper. # imgabs0 #

The invention relates to a method for establishing a PC12 cell model for evaluating the soothing effect of cosmetics. The method comprises the following steps: S1, determining model stimulation conditions; S11, detecting cell viability of a control group and cell viability of capsaicin groups with different concentrations by using a CCK-8 method; s12, observing the activation condition of the capsaicin on the TRPV1 channel of the PC12 cell by using a fluorescence microscope; s13, detecting the expression condition of the capsaicin to the TRPV1 of the PC12 cell by using an ELISA method; s14, detecting the expression condition of the capsaicin on the PC12 cell neuropeptide P substance by using an ELISA (enzyme-linked immuno sorbent assay) method; and S15, detecting the expression condition of capsaicin on IL-33 related to PC12 cell neuroinflammation by using an ELISA method. The invention also relates to evaluating the soothing efficacy of the cosmetic raw material. According to the method, the nerve-like cells are adopted to establish the cell model, the process that human skin is subjected to external stimulation and nerve reaction is excessive is effectively simulated, and the established in-vitro cell model can be used for evaluating the effectiveness of cosmetic raw materials / finished products in protecting or repairing skin nerve disorder and evaluating whether the cosmetic raw materials / finished products have soothing efficacy or not.

The invention discloses an application of homocapsaicin II in preparation of an anti-tumor drug, the homocapsaicin II is used in the anti-tumor drug independently or in combination with 5-fluorouracil or in combination with oxaliplatin, and when the homocapsaicin II is used in preparation of an anti-colorectal cancer drug, the drug concentration is 20-200 [mu] M. It is found that high capsaicin II can inhibit growth of intestinal cancer cells in vivo and in vitro, and nude mice have good tolerance to the natural compound. When the compound is used together with a first-line chemotherapeutic drug 5-fluorouracil, the drug concentration of the 5-fluorouracil can be remarkably reduced while the same treatment effect is achieved, a synergistic cancer inhibition effect is achieved, and a new research and development approach is found for anti-colorectal cancer drugs.

The invention provides stable, aqueous capsaicin injectable formulations, a unit dose containing such injectable formulations, medical kits, and methods for using such injectable formulations and unit doses to treat patients suffering from pain, such as osteoarthritic knee pain. The stable, aqueous capsaicin injectable formulations may contain, for example, capsaicin, a solubilizing agent (e.g., a polyethylene glycol ester of a (C15-C25) hydroxyalkanoic acid), an antioxidant, and water.

A composition of food or therapeutic and other substances for administration as a cloud of droplets, the cloud comprising readily-soluble droplets having a median size range of approximately 3 microns to approximately 20 microns, or 5 microns to 10 microns, or 6 microns to 10 microns, for introduction to an animal via an ortho-nasal or retro-nasal route. Agonists or antagonists may include one or more of the following: sodium iodide, sodium chloride, magnesium chloride, capsaicin, piperine, linalool, ground cinnamon, a cannabinoid, pimento, onion, clove, thyme, ginger, menthol, or TRPV antagonists, and chocolate, Irish cream, caramel, lemon, lime, mango, raspberry, watermelon, blueberry, strawberry, mint, popcorn, meat, Resolvin D2 or nicotine. Devices for delivering compositions as an aerosol are described.

The invention belongs to the field of adhesives, and particularly relates to an adhesive film with the classification number of C09J7 / 00, in particular to a rat bite prevention adhesive film and a preparation method thereof. The rat-bite-proof adhesive film structurally comprises an adhesive layer and a base material layer, the adhesive layer is made of an adhesive, the adhesive is prepared from at least a basic polymer, tackifying resin and a smell repellent, and the smell repellent comprises bitter essence S and capsaicin. The prepared rat-bite-proof adhesive film is excellent in adhesive performance and rat-proof effect and can be completely peeled off after being used, no adhesive residue appears, in addition, the rat-bite-proof adhesive film is wide in preparation raw material source and low in cost, and the product has the excellent actual use effect.

The present invention relates to a medical patch for the administration of capsaicin, such as a medical patch for use in methods of treatment, comprising an active agent-containing layer structure comprising capsaicin, and a method of making such a medical patch.

The utility model provides an insect and ant preventing plastic pipeline, which belongs to the field of plastic pipeline equipment and comprises a first polyethylene pipeline, and an insect and ant preventing sheath component used for repelling insects and ants is arranged on the outer layer of the first polyethylene pipeline. Then the first polyethylene pipeline is sleeved with the first protective sleeve, the first protective sleeve is fixedly connected with the first polyethylene pipeline, the insect and ant repellent added to the first protective sleeve can emit smell for repelling insects and ants, gathering of the insects and ants is reduced, the first protective sleeve is connected with the metal protective net, and the metal protective net can protect the first protective sleeve; the first sheath is connected with the metal protective net to prevent the first sheath from falling off, the metal protective net can effectively diffuse the smell of the insect and ant repellent and can also serve as a third defensive line to prevent insects and ants from biting the first polyethylene pipeline, the second sheath is connected to the metal protective net, capsaicin is added to the second sheath, and the insects and ants are stimulated when the insects and ants bite the second sheath.

The invention discloses an application of a compound fresh bamboo juice in a guinea pig asthma model, and relates to the field of medicines, a Hartley albino guinea pig is adopted to construct an OVA induced asthma model, and the model is verified to be successfully constructed through evaluation indexes; evaluating the efficacy of the successfully constructed guinea pig asthma model by using different doses of compound fresh bamboo juice, and evaluating the efficacy of the guinea pig asthma model by scoring guinea pig capsaicin stimulation cough inducing times, alveolar lavage fluid leukocyte number, inflammatory factor content, lung tissue hydroxyproline content and behavioral signs. And evaluating the treatment effect of the compound fresh bamboo juice through Western blot detection, lung histopathology and immunofluorescence staining indexes. In a guinea pig asthma model, high-dose and medium-dose groups of the compound fresh bamboo juice can be used for remarkably reducing the number of cough, reducing the number of white blood cells in alveolar lavage fluid and the level of inflammatory factors and inhibiting pulmonary fibrosis, and a good treatment effect is shown. The results provide powerful support for potential application of the compound fresh bamboo juice in asthma treatment.

The application belongs to the technical field of marine functional polymer antifouling materials, and discloses an acrylic metal salt resin containing silicone and a capsaicin derivative structure, a preparation method and application thereof. The acrylic metal salt resin, silicone and a compound containing the capsaicin derivative structure are combined, the viscosity of the resin is synergistically controlled by using various functional acrylate monomers, the hydrophobic silicone chain segment is effectively integrated with the capsaicin derivative structure which has antibacterial activity and hydrophilic properties, a novel acrylic metal salt resin containing silicone and the capsaicin derivative structure is prepared, the resin has multifunctional antifouling properties such as hydrophilic / hydrophobic regulation, enhanced antibacterial activity and self-polishing renewal, the raw materials are low in price, and the obtained product has excellent antibacterial performance and more than 6 months of real sea antifouling capacity.

Disclosed herein are solid forms containing a compound of formula (I): or a solvate, hydrate or isotope thereof, wherein the solid form is characterized by an X-ray powder diffraction pattern, acquired in Gandolfi mode, having at least one peak position, in degrees 2θ (± 0.2°), selected from 5.26, 6.36, 21.50 and 22.50. Also disclosed herein are solid forms containing the compound of formula (I) in which a crystalline fraction (Xc) ranges from about 15% to about 25%, and an amorphous fraction (Xa) ranges from about 85% to about 75%. Also disclosed herein are related pharmaceutical compositions and methods of treatment.

The invention discloses a capsaicin intercalated chlorite composite filler and an application thereof in an anticorrosive coating, and the method mainly comprises the following steps: peeling chlorite, preparing the composite filler from capsaicin intercalated chlorite, and mixing with other auxiliary materials according to a certain ratio to obtain the anticorrosive coating. The composite filler is applied to epoxy resin and other anticorrosive coatings, chlorite lamellas provide a physical barrier, capsaicin is controllably and slowly released from the interlayer, and the coating is endowed with long-acting and intelligent active anticorrosive ability through a'physical shielding-chemical slow release-biological bacteriostasis' triple synergistic mechanism.

The invention provides biological nano composite hydrogel as well as a preparation method and application thereof, and the preparation method of the biological nano composite hydrogel comprises the following steps: dissolving VVPS and beta-CD in a NaOH aqueous solution, heating to 60-63 DEG C, and stirring for more than 30 minutes until the VVPS and the beta-CD are completely dissolved; slowly adding PEGDGE into the solution, continuously stirring until the cross-linking agent is dissolved, raising the temperature to 65 DEG C or above, and reacting for 4 hours or above to form hydrogel; and performing swelling treatment on the hydrogel, drying, soaking in an ethanol water solution containing capsaicin for more than 48 hours, filtering, and performing freeze drying. The biological nano composite hydrogel prepared by the preparation method disclosed by the invention has good application in delivery of capsaicin and alleviation of type II diabetes mellitus.

The present invention relates to a pharmaceutical composition comprising a pharmaceutically acceptable vehicle and non-pungent derivatives of capsaicin, in their tautomeric forms and pharmaceutically acceptable salts, as the sole active ingredient, for use in the stimulation of the sphenopalatine ganglion and the enhancement of cerebral blood flow, to prevent or reduce brain injury resulting from decreased cerebral blood flow. The composition is administered via the oral transmucosal route, preferably in the form of a mucoadhesive tablet, and may be formulated for immediate or prolonged release, ensuring effective and tolerable absorption while avoiding the irritant effects associated with pungent capsaicin.

The present application relates to a kind of electrochemical detection method and system for capsaicin, detection method includes: providing three electrode system;Configuration electrolyte solution and dissolve capsaicin standard sample or sample to be measured;Electrochemical detection is carried out using three electrode system to obtain oxidation peak current signal;Based on the corresponding relationship between oxidation peak current and capsaicin concentration determines the capsaicin content in sample to be measured.Detection system includes three electrode system, battery module, power module, MCU module, electrochemical detection circuit, signal conditioning circuit and communication module, can realize the rapid, sensitive detection of capsaicin.The present application improves the detection sensitivity by carbon nanocomposite modified carbon cloth electrode, combined with portable hardware circuit design, get rid of the dependence on large instrument, applicable to the on-site rapid detection of capsaicin in food industry, provide scientific, objective technical means for hot degree quantification.