16 results about "Nystatin" patented technology

The present application relates to a method for accumulating glutathione, wherein activated yeast is fermented in a fermentation medium, nystatin and sodium dodecyl sulfate (SDS) are added in the logarithmic or stationary phase of the yeast growth, and the fermentation is continued to obtain the glutathione. The present application can significantly increase the production of glutathione, improve the utilization of raw materials, and reduce the production cost.

The invention discloses a compound nysfungin ointment, which comprises an active component, a preservative, a humectant, a thickening agent, a grease matrix and an antibacterial agent, the active component is selected from one or more of self-made mycotoxin, neomycin sulfate, permethrin and triamcinolone acetonide, the preservative is selected from benzalkonium chloride, the humectant is selected from glycerol, the thickening agent is selected from glycerol, and the grease matrix is selected from a grease matrix. The humectant is selected from humectant, the thickening agent is selected from carbomer, the grease matrix is selected from liquid paraffin and / or wool fat, the antibacterial agent is selected from thymol, and the ratio of the humectant to the thickening agent is (2-7): (0.5-3) in parts by mass. By accurately controlling the proportion of the humectant to the thickener, the texture of the ointment can be optimized, so that the skin permeability is improved, the medicine absorption is promoted, the treatment effect is improved, in addition, the form of the ointment can be kept, the active ingredients are prevented from being degraded, and the shelf life of the preparation is prolonged.

A strain of Dubois nystomatitis ( Dubosiella newyorkensis TZF-002 and its application in the fermentation and conversion of rare ginsenosides belong to the field of microbiology. The *Duboscirella nymphaeus* mentioned herein (…) Dubosiella newyorkensis TZF-002 was deposited at the China Center for Type Culture Collection on December 15, 2025, with accession number CCTCC NO: M 20252890. This invention uses total ginsenosides as raw material, first utilizing the high-β-glucosidase-producing *Duboscirella nystatin* (…). Dubosiella newyorkensis The TZF-002 method employs a mild and controlled fermentation process to transform primary ginsenosides, followed by high-temperature steam treatment, ultimately yielding rare ginsenosides Rg6, F4, Rh4, S-Rg3, R-Rg3, Rk1, and Rg5 efficiently. This method, for the first time, combines the enzymatic transformation characteristics of intestinal symbiotic bacteria with physical treatment, offering advantages such as mild conditions, low cost, and significantly superior product variety and content compared to single processes. It effectively improves the yield, bioavailability, and physiological activity of rare saponins.

The utility model relates to the field of soft capsule quality detectors, and discloses a nifuratel nystatin vaginal soft capsule quality detection device which comprises a machine body and a mounting frame, a transmission frame is fixedly mounted on the inner wall of the machine body, a display is fixedly connected to the surface of the machine body, two sliding grooves are formed in the inner wall of the mounting frame, and the transmission frame is fixedly connected with the display. A sliding block is slidably connected to the inner wall of the sliding groove, a motor is fixedly mounted at one end of the sliding block, a cleaning roller is fixedly connected to the output end of the motor, and the bottom end of the mounting frame is welded to the top of the conveying frame; the mounting frame is connected with the top of the conveying frame, a sliding block is slidably connected into a sliding groove in the inner wall of the mounting frame, a motor is mounted at one end of the sliding block, the output end of the motor is connected with a cleaning roller, and the bottom end of the cleaning roller is slidably connected with the top of the conveying frame, so that the cleaning roller is controlled to clean the surface of the conveying frame after the motor is started; and therefore, the conveying frame polluted by the soft capsule with the damaged shell can be cleaned.

The invention provides a preparation method of a composition containing nystatin. The preparation method comprises the following steps: preparing a base solution containing a suspending aid and buffer salt; preparing a wetting solution containing nystatin; cooling the base solution to 10-15 DEG C, and adding the wetting solution to prepare a mixed solution; carrying out heat preservation on the mixed solution at 10-15 DEG C for a first time, and then carrying out heat preservation at 45-50 DEG C for a second time; and cooling the mixed solution after the heat preservation is finished, then adding a preservative and a flavoring agent, and adjusting the pH value of the mixed system to 6.5-7.2 to prepare the composition containing nystatin. The preparation method is high in production efficiency, and the prepared composition containing nystatin is stable in quality.

A strain of *Duboscirella nystatin* that produces β-glucosidase ( Dubosiella newyorkensis TZF-001 and its application in the fermentation and conversion of ginsenosides belong to the field of probiotic fermentation. This *Duboscirella nystatin* (TZF-001) and its application in the fermentation and conversion of ginsenosides belong to the field of probiotic fermentation. Dubosiella newyorkensis TZF-001 was deposited at the China Center for Type Culture Collection on December 15, 2025, with accession number CCTCC NO: M20252889. This invention uses ginsenoside Rb1 as a raw material and utilizes *Duboscirella nystatin*, a bacterium that produces high levels of β-glucosidase. Dubosiella newyorkensis The TZF-001 fermentation method converts ginsenosides (Rb1) to ginsenoside Rd. After fermentation, ginsenoside Rb1 can be completely converted to Rd. This invention avoids the dependence on acid-base hydrolysis, high temperature and pressure, and steam treatment in traditional methods. Its reaction conditions are mild, and it boasts advantages such as environmental friendliness, low cost, and high product purity. This opens up a new technological path for the green and low-cost preparation of ginsenoside Rd, and has significant innovative and promotional value in the industrialization of natural drug active ingredients.

This invention discloses a nystatin microsphere with targeted enhanced antifungal function, its preparation method, and its application. The microsphere uses sodium alginate as a carrier, internally encapsulating the antifungal drug nystatin. The surface is covalently modified with the β-glucan binding domain of the Dectin-1 protein, constructing a smart drug delivery system with fungal targeting function. The microsphere preparation process is simple and reproducible, and can be scalable using an emulsion-ionic crosslinking method combined with protein coupling technology. In vitro characterization shows that the microspheres have uniform particle size and stable dispersion, and Dectin-1 modification significantly enhances their specific binding ability against Candida albicans. This targeted delivery system, while successfully preserving drug activity, significantly improves the antifungal efficiency of nystatin through Dectin-1-mediated targeting, achieving efficacy close to that of free drug, and providing a new strategy for constructing highly efficient and long-acting antifungal agents.

The invention discloses a water-soluble near-infrared fluorescent probe for detecting viscosity of a biological system as well as a preparation method and application of the water-soluble near-infrared fluorescent probe. The fluorescent probe is prepared by condensing 8-hydroxyjulolidine and 4-methyl-1-(triethylene glycol monomethyl ether) quinolinium salt, the structural formula is shown in the specification, and the probe has a remarkable Stokes shift characteristic and also has the characteristics of high response speed, high selectivity, excellent biocompatibility and the like. The probe can be used for effectively monitoring viscosity changes of stress-induced onion endoepidermis cells and mung bean slice cells and dynamic changes of nystatin-induced viscosity in juvenile zebrafish bodies, and can be applied to imaging analysis of whole mung bean plants and peanut plants. Besides, the obtained fluorescent probe is simple to prepare, high in yield, mature in synthetic route, low in cost and suitable for amplified synthesis and actual production application, and a reliable tool is provided for actual application in the fields of biomedicine, agricultural monitoring and the like.

The application discloses a preparation method of a nystatin fatty acid ester vaginal suppository responding to inflammation, a product and application thereof, and belongs to the field of medicine. The preparation method comprises the following steps: dissolving fatty acid in a solvent, adding a catalyst, uniformly mixing, and activating a carboxyl group of the fatty acid, adding nystatin, and stirring to obtain nystatin fatty acid ester. The fatty acid is saturated or unsaturated fatty acid with a carbon chain length of 4-17 carbons. The application effectively solves the problems that nystatin is unevenly distributed in the suppository matrix and is prone to suppository sedimentation and stratification. Meanwhile, the nystatin fatty acid ester disclosed by the application can be hydrolyzed under the action of leukocyte esterase at an inflammation site of a vagina, release nystatin raw medicine, and play a bactericidal role responding to inflammation. In the non-inflammation area, the nystatin fatty acid ester is hardly hydrolyzed into nystatin, and thus the local adverse reaction of the vagina caused by nystatin can be effectively reduced.

The invention belongs to the technical field of biological medicines, and particularly relates to application of nystatin in preparation of a product for treating LINC00516 high-expression lung adenocarcinoma. The invention discloses the effect of the long-chain non-coding RNA LINC00516 in abnormal activation of the lung adenocarcinoma cell cycle for the first time. Researches show that LINC00516 is directly combined with CDK1, the kinase activity of CDK1 is remarkably enhanced, and the inhibitory phosphorylation level of CDK1 is reduced, so that lung adenocarcinoma cells are driven to quickly enter a G2 / M phase, and tumor cell proliferation is accelerated. The invention further innovatively proposes that nystatin is used as an intervention means, and by blocking the combination of LINC00516 and CDK1, the activity of CDK1 is reduced, and the proliferation capacity of tumor cells is inhibited. In-vivo and in-vitro experiments prove that nystatin significantly inhibits the growth of lung adenocarcinoma cells highly expressing LINC00516, so that a brand-new molecular targeted therapy strategy is provided for clinic.

The invention provides a method for improving vibrio splendidus infection resistance of stichopus japonicus, which is a method for preventing and treating stichopus japonicus diseases caused by vibrio splendidus by inhibiting pathogenesis related to vibrio splendidus outer membrane vesicles. The composition capable of improving the vibrio splendidus infection resistance of the stichopus japonicus comprises chlorpromazine and nystatin. The composition provided by the invention has no obvious toxicity to coelomic cells of the stichopus japonicus, and can inhibit endocytosis of OMVs to the maximum extent, so that the optimal prevention and control effect is realized. After the OMVs are treated by chlorpromazine and nystatin, the endocytosis efficiency of the OMVs is reduced by more than 50%.

The invention belongs to the technical field of organic synthesis, and provides a mitochondrial targeting and viscosity-sensitive near-infrared fluorescent probe as well as a preparation method and application thereof. The fluorescent probe has positive charges, can be selectively enriched in mitochondria, and can dynamically monitor the viscosity of the mitochondria. The synthesis steps of the probe are short, and post-treatment is easy; the selectivity, the sensitivity and the stability are high. The excitation wavelength and the emission wavelength are in a near-infrared region, so that biological autofluorescence interference can be effectively avoided, and deep tissue penetration potential is achieved. The probe has been successfully applied to real-time monitoring of mitochondrial viscosity level in cancer cell autophagy and apoptosis processes and detection of viscosity change in zebrafish under nystatin stimulation. The invention provides an efficient tool for dynamic monitoring of mitochondrial viscosity, has important application value in the aspects of early diagnosis, efficacy evaluation and the like of mitochondrial related diseases such as cancer and the like, and meets clinical and scientific research requirements.

The invention discloses a nystatin solution as well as a preparation method and application thereof, and the nystatin solution is prepared from the following raw materials in parts by weight: 20-50 parts of nystatin, 110-220 parts of dimethyl sulfoxide, 1.5-2.0 parts of a preservative, 0.5-1 part of an antioxidant and 737-880 parts of 1, 2-propylene glycol. According to the invention, a composite solvent system of dimethyl sulfoxide and propylene glycol is creatively adopted, and a remarkable synergistic effect is generated by utilizing the extremely strong dissolving capacity of dimethyl sulfoxide and the auxiliary solubilizing and diluting effects of propylene glycol. The system can completely dissolve 50 parts by weight of nystatin to form a clear, transparent and uniform stable solution, so that the technical bottleneck that nystatin cannot be prepared into a high-content solution due to insolubility in water is fundamentally solved, and a foundation is laid for drinking water administration of poultry groups.

The invention discloses a streptomyces strain and an application of the streptomyces strain in production of nystatin A1. The streptomyces disclosed by the invention is streptomyces albus J1074-nystatin BGC-SSC133, and the preservation number of the streptomyces albus is CGMCC (China General Microbiological Culture Collection Center) No.36300 in the General Microbiological Culture Collection Center of the China Committee for Culture Collection of Microorganisms). Experiments prove that the streptomyces albus J1074-nystatin BGC-SSC133 can be used for efficiently preparing the nystatin A1, and the content of the nystatin A1 reaches 106.30 [mu] g / mL + / -8.45 [mu] g / mL. The method has important economic value and application prospect.

The application discloses a nystatin solution and a preparation method and application thereof, which is prepared from the following raw materials in parts by weight: nystatin 20-50 parts, dimethyl sulfoxide 110-220 parts, preservative 1.5-2.0 parts, antioxidant 0.5-1 part and 1,2-propylene glycol 737-880 parts. The application creatively adopts a composite solvent system of dimethyl sulfoxide and propylene glycol, utilizes the extremely strong dissolving capacity of dimethyl sulfoxide and the auxiliary solubilization and dilution effect of propylene glycol, and produces a significant synergistic effect. The system can completely dissolve up to 50 parts by weight of nystatin, forms a clear, transparent and uniform stable solution, fundamentally solves the technical bottleneck that nystatin cannot be prepared into a high-content solution due to poor water solubility, and lays a foundation for poultry group water medication.

The invention relates to the technical field of pharmaceutical analysis, in particular to a method for detecting applicable impurities of a nystatin system and application of the method. Specifically, research finds that structural information of an impurity A and an impurity B in a system applicable solution of nystatin is not reported in existing pharmacopoeia standards and related literatures of nystatin, and the impurity A and the impurity B are main degradation impurities of nystatin and related preparations and have a growth trend in a stable period. Therefore, the preparation and structural analysis of the two impurities are of great significance. Meanwhile, the invention develops a method for detecting the impurity A and the impurity B in nystatin and related preparations, and the method has good specificity, accuracy and repeatability, so that the method has good practical application value.