147 results about "Nystatin" patented technology

Several diterpene glycosides (e.g., rubusoside, rebaudioside, steviol monoside and stevioside) were discovered to enhance the solubility of a number of pharmaceutically and medicinally important compounds, including but not limited to, paclitaxel, camptothecin, curcumin, tanshinone HA, capsaicin, cyclosporine, erythromycin, nystatin, itraconazole, and celecoxib. The use of the diterpene glycoside rubusoside increased solubility in all tested compounds. The diterpene glycosides are a naturally occurring class of water solubility-enhancing compounds that are non-toxic and that will be useful as new complexing agents or excipients in the pharmaceutical, agricultural (e.g., solubilizing pesticides), cosmetic and food industries. Aqueous solutions by using rubusoside to increase the solubility of otherwise insoluble drugs will have several new routes of administration. In addition, aqueous solutions of therapeutic compounds with rubusoside were shown to retain the known pharmacological activity of the compounds.

A topical mycological treatment composition for medical, veterinarian, or dental use contains as active ingredients clotrimazole, ketoconazole, micanazole, nystatin, tolnaftate, propionic acid, sodium propionate, undecelynic acid, and zinc undecelynate. These ingredients are contained in a natural cream base, and the base may also contain an anti-inflammatory agent and an antibacterial agent.

This invention relates to a method of treating otitis externa, and in particular otitis externa of fungal etiology, using topical medication, including antifungal agents such as, for example fluconazole, voriconazole, itraconazole, clotrimazole, amphotericin B, caspofungin (Cancidas®), micafungin (Mycamine®), terbinafine, naftifine, butenafine, amorolfine, ravuconazole, posaconazole, flucytosine, econazole, enilaconazole, miconazole, oxiconazole, saperconazole, sulconazole, terconazole, tioconazole, nikkomycin Z, anidulafungin (LY303366), nystatin, pimaricin, griseofulvin, ciclopirox, haloprogin, tolnaftate, and undecylenate.

This invention relates to a method of treating otitis externa using a topical combination medication, including one or more antifungal agent such as, for example fluconazole, voriconazole, itraconazole, clotrimazole, amphotericin B, caspofungin, micafungin, terbinafine, naftifine, butenafine, amorolfine, ravuconazole, posaconazole, flucytosine, econazole, enilaconazole, miconazole, oxiconazole, saperconazole, sulconazole, terconazole, tioconazole, nikkomycin Z, anidulafungin (LY303366), nystatin, pimaricin, griseofulvin, ciclopirox, haloprogin, tolnaftate, and undecylenate and one or more antibacterial agent such as neomycin sulfate, polymyxin B sulfate, colistin sulfate, gentamycin, tobramycin, chloramphenicol, Ciprofloxacin, Ofloxacin, a penicillin compound, a cephalosporin compound, a macrolide compound, a fluoroquinolone compound, streptomycin, or kanamycin.

The invention discloses a special microbial fertilizer for Magnolia biloba. The microbial fertilizer is characterized by comprising raw materials in parts by weight as follows: 2-4 parts of bacillus subtilis, 1-3 parts of Frankia, 3-5 parts of Streptomyces, 2-4 parts of nystatin, 50-60 parts of urea, 25-30 parts of ammonium phosphate, 15-20 parts of sodium borate, 10-15 parts of ferrous sulfate and the like. According to the physiological habits of the Magnolia biloba, proper technologies and a specific fertilizer formula are adopted, so that the defects that seeds of the Magnolia biloba are difficult to sprout, seedlings don't emerge uniformly, and the survival rate is low are overcome, and conditions are created for large-area cultivation and application of the Magnolia biloba.

Antimicrobial and contraceptive compositions and methods which prevent and / or reduce the risk of transmission of sexually transmitted diseases through sexual activity as well as prevent and / or reduce the risk of pregnancy are provided. The compositions contain (1) a matrix-forming agent, (2) a bio-adhesive agent, (3) a buffering agent, (4) optionally a humectant, (5) optionally a preservative, and (6) water; wherein the composition is suitable for application within the vagina; wherein the compositions form a semisolid matrix on contact with ejaculate (thereby trapping ejaculated microbes and spermatozoa); wherein the composition causes hardening of cervical mucus (thereby decreasing the probability of sperm entry); wherein the composition forms a bio-adhesive layer over vaginal surfaces (thereby preventing or reducing the risk of contact of STD-causing microbes with the vaginal surfaces); wherein the composition maintains an acidic vaginal pH of less than about 5 in the presence of semen ejaculated from the male; and wherein the composition does not significantly impair the natural microbiological balance within the vagina. The antimicrobial and contraceptive compositions may also contain additional antimicrobial and / or contraceptive agents (e.g., nonoxynol-9, octoxynol-9, benzalkonium chloride, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H2SO4-modified mandelic acids, povidone iodine, itraconazole, ketoconazole, metronidazole, clotrimazole, fluconazole, teraconazole, miconazole, tinidazole, iconazole, chloramphenicol, nystatin, cyclopiroxolamine, and the like).

The present invention relates to the new use of an already known biomolecule methyl-beta-orcinol carboxylate of formula 1 isolated from a lichen (Everniastrum cirrhatum), for treating pathogenic fungal infections of humans that are resistant to polyene and azole antibiotics such as amphotericin B, nystatin, clotrimazole etc.

An oral rinse formulation for the treatment or prophylaxis of mucositis or stomatitis comprises one or more of the following components in combination with pharmaceutically acceptable excipients or additives: a) at least one corticosteroid; b) at least one anti-histamine; c) at least one topical anaesthetic; and, d) at least one anti-fungal antibiotic agent. A stable nystatin containing formulation is also provided comprising a buffering agent, a preservative, a chelating agent and an anti-oxidant.

The invention discloses a vaginal gel which is prepared from the following raw materials: Nifuratel and Nysfungin 300-600 parts, glycerin 200-400 parts, gel base material 100-500 parts. The preparing process consists of steps of abrading homogeneously, charging charging base materials into turbid liquor and stirring homogeneously, and adjusting pH to be 6-7.

The invention discloses a microbial fertilizer specially used for magnolia officinalis powdery mildew. The microbial fertilizer is characterized by comprising the following components in parts by weight: 2-4 parts of bacillus subtilis, 1-3 parts of frankiaceae, 3-5 parts of streptomycete, 2-4 parts of nystatin, 50-60 parts of urea, 25-30 parts of ammonium phosphate, 15-20 parts of boron sand, 10-15 parts of ferrous sulfate and the like. According to the physical habits of magnolia officinalis, a proper technology and a special fertilizer formula are adopted, so that the shortcomings that seeds of the magnolia officinalis are difficultly germinated, seedlings untidily grow, and the survival rate is low are overcome; conditions are created for large-area culture and application of the magnolia officinalis.

The invention discloses a special polyelement microorganism fertilizer for preventing yam anthracnose and a preparation method of the special polyelement microorganism fertilizer. The special polyelement microorganism fertilizer comprises components of raw materials in parts by weight as follows: 2-4 parts of bacillus subtilis, 1-3 parts of frankia, 3-5 parts of streptomycete, 2-4 parts of nystatin, 50-60 parts of urea, 25-30 parts of ammonium phosphate, 15-20 parts of borax, Chinese herbal medicinal ingredients and the like. The special polyelement microorganism fertilizer can reduce the morbidity of the anthracnose, increase the yield of yams, and improve the soil condition.

The present invention relates to a treating method for sterilizing the explants, which have bacteria in tissues. The treating method is the plant material of the explants are implemented with the common treatment and the part of the fringe of the explants whose color changes with the sterilization is cut and then the explants are cut into small pieces of 1 to 3 cm for use; the method is characterized in that the explants are separately transplanted into different culture media of different concentrations; 8 to 10 explants are transplanted in one triangular bottle and the fringe of every explant contact the culture media; the explants are put in a culture room for cultivation. The method of the present invention is characterized by simple operation; the three antibiotics of carbenicllin, streptomycin sulphate and nystatin have obvious effect on the sterilization of the explants which not only effectively constrain the bacteria (100 percent when the three antibiotics are injected with the amount of 500 plus 100 plus 1000mg an hour) but also basically control the growth of fungus.

The invention provides a specific beriberi medicament, which is mainly prepared from the following raw materials in portion by weight: 3 to 12 portions of calcined alum, 1 to 4 portions of almond, 0.25 to 1 portion of metronidazole tablet, 0.15 to 1 portion of nystatin tablet, 0.15 to 1 portion of furazolidone tablet, 0.25 to 1 portion of oxytetracycline tablet, 0.15 to 1 portion of vitamin B1 tablet, 0.25 to 1 portion of vitamin B2 tablet, and 10 to 30 portions of clotrimazole cream. The medicament takes antibacterial medicaments as main ingredients, and can kill bacteria and fungi which cause the beriberi; the adding of vitamin B complex and vitamin C aims to repair wound surfaces, promote the healing, and ensure that the skin restores to normal more quickly; the calcined alum ensures that medicament application positions keep relatively dry; the almond relieves internal heat; various components supplement each other, can quickly and effectively treat the beriberi, and enables patients to recover; and at the same time, the medicament also has better efficacies in treating sole sweating and foot odor.

The invention discloses a microbial feed additive for treating piglet yellow and white dysentery and a preparation method thereof. The additive is prepared from the main components of bacillus subtilis and saccharomyces cerevisiae which are mixed with baking soda, xylo-oligosaccharides, vitamins, vitamin complex, glucose and the like according to certain proportions. The microbial feed additive has the following advantages that: the active substances such as subtilin, polymyxin, nystatin, gramicidin and the like generated in the growing process of the bacillus subtilis have obvious inhibitionto pathogens or conditioned pathogens of endogenous infection; cell wall polysaccharides of the saccharomyces cerevisiae and a great amount of nucleotides and bioactive peptides generated in the growing process of the saccharomyces cerevisiae can improve the immunity of animals, and a compound taste substance is also generated in the growing process of the saccharomyces cerevisiae to promote animal feeding; the baking soda replenishes electrolyte; the xylo-oligosaccharides selectively proliferate beneficial bacteria such as bifidobacterium and the like; the vitamins have the effects of resisting stress and replenishing nutrition; and the glucose has the effects of supplying energy and promoting healing.

Described are compounds and methods useful for selectively targeting cancer stem cells. The compounds preferentially induce differentiation and / or reduce the proliferation of cancer stem cells relative to normal stem cells. Compounds useful for selectively targeting cancer stem cells include polyene macrolides such as Nystatin or Amphotericin B, analogs thereof and pharmaceutically acceptable salts thereof.

The invention discloses a special compound microorganism fertilizer for preventing yam anthracnose and a preparation method of the special compound microorganism fertilizer. The special compound microorganism fertilizer for preventing the yam anthracnose comprises components in parts by weight as follows: 2-4 parts of bacillus subtilis, 1-3 parts of frankia, 3-5 parts of streptomycete, 2-4 parts of nystatin, 50-60 parts of urea, 25-30 parts of ammonium phosphate, 15-20 parts of borax, 10-15 parts of ferrous sulfate, 8-10 parts of manganese sulfate, 10-12 parts of zinc sulfate, 20-24 parts of calcium superphosphate, 80-100 parts of peanut cakes, 70-80 parts of a soybean meal, 100-120 parts of maize straw, 90-100 parts of expansion chicken manure, 40-50 parts of waste of a chicken slaughter house, 0.2-0.4 part of multi-effect triazole and 0.4-0.6 part of gibberellin. The special compound microorganism fertilizer can reduce the morbidity of the anthracnose, increase the yield of yams, and improve the soil condition.

The invention relates to a nifuratel-nystatin soft capsule-type suppository and a preparation method thereof. Nifuratel-nystatin sol in the nifuratel-nystatin soft capsule-type suppository is preparedfrom the following components in parts by weight: 40-60 parts of nifuratel, 3-5 parts of nystatin, 2-3 parts of carbomer, 1-2 parts of ethylparaben, 50-70 parts of glycerinum, 70-100 parts of ethyl alcohol, 20-30 parts of pH buffer liquid and 700-800 parts of medical pure water. The preparation method comprises the following steps of 1, raw material preparation; 2, liquid medicine preparation, wherein the nifuratel and the nystatin are mixed evenly in a sterile environment, then through a sterile filtering system, sterile filtering is conducted, and then micro-pore filtering is conducted, sothat a liquid medicine is obtained for later use; 3, gel matrix preparation; 4, nifuratel-nystatin sol preparation; 5, capsule pressing; 6, soft capsule-type suppository preparation. The nifuratel-nystatin soft capsule-type suppository and the preparation method thereof have the advantages that body hormone secretion is not affected, the sterilization effect is good, and the preparation method issimple.

The present invention is a topical skin preparation for treatment of fungal infections of the skin and nails. The preparation comprises triacetin in combination with an antifungal agent. In a preferred form, the preparation further comprises, a fatty acid source such as a fish oil. In a preferred embodiment, cod liver oil and tolnaftate are used in combination with triacetin. The concentrations of these constituents are 96.0-99.0% concentration triacetin, 0.5-3.0% concentration tolnaftate and 0.5-1.0% concentration cod liver oil, in one preferred embodiment. Other compounds, such as ethyl alcohol, amino acids such as n-acetylcysteine, and herbal additives may also be added to the preparation. Further, other antifungal agents such as nystatin, clortimazole, econazole, ketoconazole, miconazole, solconazole, oxiconizole, naftifine, terbinafine, and butenafine, for example, may be substituted for the antifungal agent tolnaftate. The preparation of the present invention is effective in treating immune compromised patients and those with diabetes, as well as relatively healthy persons.

The invention provides a nystatin flexible liposome and external preparation gel and simultaneously discloses a preparation method of the nystatin flexible liposome. Through the nanometer liposome technology, nystatin is covered and sealed in the liposome, the solubility of the nystatin is enhanced, the liposome recipe is improved, sodium cholate or sodium deoxycholate is added, the flexible liposome is prepared, the liposome pereutaoeous permeation is enhanced, in addition, the nystatin stability can be improved, a nystatin cutaneous penetration path is developed, and the treatment effect is realized in aspects of skin superficial layer or deep infection and systemic fungal infection. The nystatin flexible liposome is prepared into the gel, the detention time of the nystatin flexible liposome on the skin is prolonged, the use is simple and convenient, the cost is low, in addition, the compliance of users is improved, the toxicity is reduced, medicine storage bases can be formed on the skin, medicine is continuously released, and the medicine acting time is prolonged.

The present invention is a topical skin preparation for treatment of fungal infections of the skin and nails. The preparation comprises triacetin in combination with one or more antifungal agents. In a preferred form, the preparation comprises a combination of the antifungal agents tolnaftate and grisiofulvin are used in combination with triacetin. The concentrations of these constituents are 40 to 50% concentration triacetin, 30 to 50% acetone, 0.5-3.0% concentration tolnaftate and 0.5-4.0% concentration grisiofulvin, in one preferred embodiment. Other compounds, such as ethyl alcohol, acetone, amino acids such as n-acetylcysteine, and herbal additives may also be added to the preparation. Further, other antifungal agents such as nystatin, clortimazole, econazole, ketoconazole, miconazole, solconazole, oxiconizole, naftifine, terbinafine, and butenafine, for example, may be substituted for the antifungal agents tolnaftate and grisiofulvin. The preparation of the present invention is effective in treating immune compromised patients and those with diabetes, as well as relatively healthy persons.

The invention discloses a modeling method of a helicobacter pylori infection animal model. The modeling method comprises the steps of: 1, by using a 4-weeks old female C57BL / 6 mouse as the experimental animal, performing intra-gastric administration for 3 to 7 days by mixed antibiotic, wherein the mixed antibiotic is composed of gentamicin, vancomycin and nystatin; 2, raising the C57BL / 6 mouse which has been subjected to the intra-gastric administration in the step 1, for 6 to 8 days; 3, inoculating helicobacter pylori: fasting the C57BL / 6 mouse obtained in the step 2, carrying out intra-gastric administration by helicobacter pylori, and feeding after 8 to 12 hours, wherein the inoculating in the step 3 is performed one time every other day, and performed 2 to 4 times in total; and 4, raising the mouse which has been inoculated for 2 to 4 times in the step 3. In the modeling method provided by the invention, the experimental time is short, the operation time is less, the order of magnitude of the helicobacter pylori infection is high, and the infection time is endurable; the model can be widely used for the method of helicobacter pylori infection animal in related researches.

The invention discloses a method for preparing an antibacterial compound, which comprises the following steps of: inoculating bacillus subtilis (Bacillus subtilis) GMCC No.4140 into a fermentation medium, culturing for 12 to 60 hours, separating and purifying. The antibacterial compound has strong effect of inhibiting Candida albicans and better antibacterial effect than the conventional nystatin. The antibacterial compound has strong effect of inhibiting the Candida albicans and other yeast fungi, also has good effect on Aspergillus niger and other filamentous fungi, and simultaneously has better effect of inhibiting Escherichia coli and other bacteria. The antibacterial compound produced by the method has high potency, the technical flow is simple, and antibacterial substances are easy to separate and purify.

This invention discloses an immunosuppressive cell-capturing material comprising a molded body that includes: a readily hydrolyzable condensation polymer having an amino group; a poorly hydrolyzable polymer coating the readily hydrolyzable condensation polymer; and a ligand-conjugated poorly hydrolyzable polymer coating the poorly hydrolyzable polymer, wherein the ligand is at least one selected from the group consisting of a NH2 group, a secondary amino group, a tertiary amino group, a polyamine residue, a basic cyclic polypeptide residue, an aminoglycosidic compound residue, chloroquine, primaquine, mefloquine, imiquimod, and nystatin, and wherein the content of the amino group in the molded body is 150 μmol / g or less. The invention also discloses an immunosuppressive cell-capturing column filled with the capturing material.

The invention relates to a nifungin-canstat vagina effervescent tablet. Wherein, it uses nifungin and canstat, with acid-alkali adding system, and stuff or directly being compressed into tablet or particles then to be compressed into tablet, or uses macrogol to cover the alkali, then to be compressed into tablet. The invention uses the acid alkali system which will generate carbon dioxide gas when meeting water as slaking agent; therefore, the tablet will foam and slake when adsorbs water in vagina, to disperse the elements into vagina completely, as uterine cervix, etc.

The invention discloses a new type of Neisseria gonorrhoeae medium, which is characterized in that the components include basal medium, sheep blood and bacteriostatic agent: ①Basic medium: 1.0-2.0 parts of peptone, 0.05-0.15 parts of cornstarch, K2HPO40. 2-0.8 parts, KH2PO4 0.05-0.2 parts, NaCl 0.25-1.0 parts, agar 1-3 parts; ② sheep blood 3-10 parts; ③ bacteriostatic agent: vancomycin 0.003-0.005 parts or lincomycin 0.003-0.01 parts, polymyxin 0.0075-0.015 parts, nystatin 0.417-0.667 parts and trimethoprim 0.005-0.01 parts. The culture medium is suitable for grassroots medical institutions, has excellent performance, and has a simple and reasonable preparation method, which not only overcomes the shortcomings in the prior art, but also ensures the effect of separation and culture.

The invention relates to a pharmaceutical composition for synergetic treatment and prevention of fungal infections and a preparation method thereof. The composition comprises nysfungin and menthol with a weight ratio of (1-20):1 as active ingredients.

The invention relates to the medical technology field, and discloses an application of lysine as a synergist for preparing antifungal drugs like polyenes or echinocandins. The antifungal drugs may be amphotericin B, nystatin or caspofungin. The amount of lysine or pharmaceutically acceptable salts thereof in the antifungal drug effective concentration is 0.03-0.5mM. As shown in an experiment, the combination application of antifungal drugs like amphotericin B, nystatin and caspofungin, can also ensure the treatment effect on superficial and deep fungal infections in case of decrease of drug dose, and the combination can be used as a synergist of the antifungal drugs. The lysine, as the synergist of the antifungal drugs, can decrease the medical dosage of the antifungal drugs like polyenes or echinocandins, thereby alleviating the toxic and side effect of medicaments, effectively treating fungal infection, and having a high application value.

Belonging to the field of veterinary biological products, the invention discloses a mycoplaa hyopneumoniae selective isolation medium and a preparation method thereof. The mycoplaa hyopneumoniae selective isolation medium comprises the following components: brain heart infusion, PPLO broth, 10*Hank's solution, yeast extracted liquid, lactalbumin hydrolysate, an amino acid composition, glucose, penicillin, nystatin, 0.1% phenol red, inactivated pig serum, specific growth inhibiting serum and deionized water. The mycoplaa hyopneumoniae selective isolation medium provided by the invention has thecharacteristics of short isolation time, high isolation success rate, viable bacteria titer and isolation sensitivity far higher than those of the medium in the prior art, and is suitable for rapid growth of mycoplaa hyopneumoniae.