169 results about "Oral disease" patented technology

The invention provides an oral disease early screening system and screening method based on an artificial intelligence auxiliary diagnosis system. According to the system, oral images and medical information of a patient are collected through a screening tool, an AI model is trained for auxiliary diagnosis, and intelligent services are provided for doctors in the diagnosis system. Artificial intelligence is introduced into oral medicine, the oral disease diagnosis efficiency and accuracy can be remarkably improved, support is provided for intelligent medical treatment, remote medical treatment and the like, and good application prospects are achieved. The method is suitable for the cross field of oral medicine and artificial intelligence, can be applied to hospitals, physical examination institutions and the like, and realizes early screening and early diagnosis of oral diseases.

The invention discloses an oral cavity panoramic image processing system, and the system comprises an image collection module which is used for collecting an initial oral cavity panoramic image containing a plurality of oral cavity diseases; the image processing module is connected with the image acquisition module and is used for performing target detection and instance segmentation labeling on the initial oral panoramic image and expanding a training data set by adopting a data enhancement technology to obtain a target oral panoramic image; a model construction module connected with the image processing module and used for training an MMC-YOLO network model through the target oral panoramic image to obtain a target MMC-YOLO network model; and the analysis and detection module is connected with the model construction module, and is used for performing synchronous detection of tooth concurrent oral diseases, comprehensive analysis of multi-dimensional pathological information and accurate recognition of multi-scale pathological changes through the target MMC-YOLO network model to obtain an analysis result. The system provided by the invention realizes synchronous detection and accurate grading of multiple types of focuses in the oral panoramic image.

The present invention relates generally to methods and systems that can be used to analyse the mouth condition of an individual. The methods and systems can be used in the identification of an oral condition or disease to provide a personalised holistic treatment care plan for the individual. More particularly, the present invention relates to methods and systems that employ artificial intelligence capabilities for generating a treatment plan for an identified oral condition or disease.

The invention relates to the technical field of oral medical treatment, in particular to an oral disease analysis method and system based on AI intelligent recognition. Comprising the following steps that oral cavity three-dimensional surface data are obtained through an oral scanning module integrated with a dental chair, and the oral scanning module adopts a structured light coding and multi-view fusion algorithm; an oral soft tissue high-definition image is collected through an endoscope module, and an AI analysis unit is arranged in an endoscope to recognize mucous membrane lesion features in real time; calling CBCT image data of the patient, and aligning a three-dimensional image with oral scanning data through a spatial registration algorithm; the mouth scanning data, the endoscope image and the CBCT data are subjected to multi-modal fusion by adopting a dynamic weight fusion mechanism. According to the scheme, the problem of accurate registration of cross-modal data, the lack of a dynamic quality evaluation mechanism of heterogeneous data and the real-time collaboration bottleneck of dispersed equipment can be solved.

The invention discloses a lactobacillus delbrueckii subsp. Lactis TG001 and application thereof in improving oral health, and belongs to the technical field of probiotic application, the preservation number of the lactobacillus delbrueckii subsp. Lactis TG001 is CCTCC NO: M 20241941, the preservation place is China Center for Type Culture Collection in Wuhan, and the preservation date is September 9, 2024. The lactobacillus delbrueckii subsp. Lactis TG001 has a good inhibition effect on common oral pathogens such as streptococcus mutans and porphyromonas gingivalis, particularly can inhibit the growth of cariogenic bacteria streptococcus mutans by generating hydrogen peroxide and remove biofilm formation, and has good tolerance to antibacterial substances in an oral environment. Therefore, the oral cavity diseases such as dental caries, periodontitis and ozostomia can be prevented, the micro-ecological environment of the oral cavity is effectively improved, meanwhile, the peculiar smell of the oral cavity is relieved, and good application prospects are achieved in preparation of products for preventing and / or treating the oral cavity diseases such as dental caries and periodontitis.

The invention relates to an intelligent oral disease risk prediction and analysis system, which comprises an oral health data acquisition module, a data preprocessing and standardization module, a multi-modal data fusion module, a risk prediction and suggestion module and a medical interaction interface module, the data preprocessing and standardization module is used for preprocessing original data and performing standardization operation, the multi-modal data fusion module is used for multi-modal data fusion, and the risk prediction and suggestion module is used for oral disease risk prediction and generation of personalized medical intervention suggestions. And the medical interaction interface module is used for checking a prediction report by a user, receiving medical suggestions and providing feedback information. According to the intelligent oral disease risk prediction analysis system, a multi-modal oral data feature extraction algorithm based on a convolutional neural network is proposed to perform feature extraction on data; and an oral disease risk prediction algorithm based on machine learning is provided to predict the oral disease risk.

Provided is a compound of formula I, X-Y (I) wherein: Y comprises a peptide fragment of formula IV, [Ala] m-[Lys-V]n-Lys-V (IV) in which m represents 0 or 1, n represents an integer 0, 1, 2, 3 or 4 and, each V independently represents a 2 to 4 amino acids sequence, in which the amino acids are selected from one or more of the group Lys, Pro, Hyp, diHyp, Thr, pThr, DOPA, Tyr, and Ser; and X represents at least one optional substituent selected from: (i)a lipid, which lipid is selected from the group consisting of vitamin A, vitamin E, cholesterol and a fatty acid; and / or (ii)a non-steroidal anti-inflammatory drug, which compounds are useful in medicine, including as pharmaceutical excipients, adhesives and film-forming materials and / or are useful in the treatment of conditions characterised by inflammation, including wounds, burns, and disorders of the mucosa, such as skin diseases, oral diseases, gynecological diseases and IBDs.

The invention relates to the technical field of oral health, and discloses an old people oral health behavior monitoring method and system based on multi-source data fusion. The method comprises the following steps: acquiring multi-modal data of a plurality of old people in a historical time period, preliminarily identifying oral cavity states of the old people based on oral cavity image data, and obtaining health indexes; adjusting the health index based on different age ranges, and if the adjusted health index is smaller than a first threshold value, performing time-space alignment association on the multi-modal data; judging whether the modal data in the historical time period has missing modals or not, performing fusion processing on the same modal data in the historical time period based on a judgment result to obtain preliminary fusion vectors, and fusing the preliminary fusion vectors of different modals to obtain a comprehensive feature vector; and establishing an evaluation model to analyze the comprehensive feature vector, and outputting the risk probability and the disease type of the oral disease of the elderly user in the future. According to the invention, the risk prediction precision of oral health of old people is improved.

The invention relates to the field of oral care, in particular to an intelligent oral health assessment and personalized care system and method. The oral image data of the user is acquired and preprocessed through the data acquisition and processing module, and the oral disease recognition module is used for analyzing the data based on a deep learning algorithm to recognize diseases. The system further combines a personalized nursing recommendation module and a personalized product recommendation module, and generates and recommends personalized nursing schemes and products according to the disease recognition result and the user information. And the health monitoring and feedback module monitors oral health of the user in real time and dynamically adjusts a nursing scheme and product recommendation. According to the system, the intelligent, personalized and dynamic oral health management level is effectively improved through technical innovation of an innovative framework, an advanced algorithm, multi-modal data fusion, a dynamic adjustment mechanism and the like, the problems of an existing system are solved, and comprehensive and efficient oral health nursing is achieved.

The invention provides whitening and halitosis removing toothpaste and a preparation method thereof. The toothpaste is prepared from, by mass, 20%-30% of hydrated silica, 2%-4% of pyrophosphate, 20%-30% of clove powder, 20%-30% of sodium phytate, 0.5%-1.5% of a thickening agent, 20%-30% of hydroxyapatite, 2%-4% of modified glycerin, 2%-4% of a humectant, 20%-30% of sodium tripolyphosphate, 0.1%-0.2% of a bacteriostatic agent, 0.1%-0.2% of a sweetening agent, 2%-4% of a stain remover, 1.0%-2.0% of a foaming agent, 1.0%-1.5% of a preservative and the balance deionized water. Compared with the prior art, the toothpaste composition with the whitening function, disclosed by the invention, has the advantages that by adding the biological enzyme for decomposing pigments and carbohydrates remained in an oral cavity or teeth to generate hydrogen peroxide with a bleaching function, not only can pigments causing exogenous stains of the teeth be removed, but also endogenous stains can be removed; meanwhile, the stimulation to the oral cavity is reduced, and the clove has the effect of removing halitosis because the fragrance of the clove is strong, so that the clove can be used for treating oral diseases and eliminating the odor in the oral cavity.

The invention discloses an oral disease detection method based on an artificial intelligence large model, and relates to the technical field of oral medicine. Comprising the following steps: acquiring a tooth focus picture and corresponding oral cavity internal state description, respectively extracting picture feature information of the tooth focus picture and text feature information of the oral cavity internal state by adopting a feature extraction block BERT and a multi-scale feature extraction block MFEM, and identifying and eliminating false negative samples therein; a total loss function and a dynamic label distribution strategy are introduced into a YOLOv8 network, an improved YOLOv8 network is obtained, a data set is divided into a training set and a test set, the training set and the test set are sequentially input into the improved YOLOv8 network for verification, the verified YOLOv8 network is obtained, a tooth focus picture and corresponding text information are input into the verified YOLOv8 network, and focus area type detection and text description are obtained. According to the invention, detection and classification of various diseases in the oral cavity can be effectively improved, and corresponding focus area description and suggestion are given.

The invention belongs to the technical field of medical materials, and discloses an external gel material for treating oral mucositis and a preparation method of the external gel material. The gel is temperature-sensitive slow-release antibacterial gel, adopts safe components, has a temperature-sensitive characteristic, is in a sol state in a low-temperature state, is convenient to smear, can be converted into a gel state when the temperature is close to the body temperature of a human body, can be tightly attached to an oral mucosa, is good in adhesiveness to the oral mucosa, can also slowly release drugs, and has relatively strong antibacterial performance; the repair and regeneration of oral mucosa epithelial tissues can be promoted. The gel can effectively act on the treatment process of oral diseases, is also suitable for daily oral care, and provides guarantee for oral health.

The invention discloses an oral care composition for dogs and cats, oral care cream and a preparation method of the oral care cream. The oral care composition for dogs and cats is prepared from the following raw materials: lactoferrin, nano zinc oxide, lysozyme, glucose oxidase, xylooligosaccharide, water-soluble sodium ascorbate phosphate, an inactivated lactobacillus fermentation product, sodium humate, sodium copper chlorophyllin, catnip, yucca, tea polyphenol, glycine and resistant dextrin. The components act together, the whole pet oral care solution is suitable for pet oral care, efficacy tests prove that the pet oral care solution can effectively promote oral health of pet dogs and cats, and the comprehensive effect of pet oral care is achieved. The oral care composition with a scientific formula is properly added, so that the oral saliva colonies of dogs and cats can be inhibited, the content of hydrogen sulfide in the oral cavities of pet dogs and cats can be reduced, the halitosis of pets can be quickly relieved, and fresh breath can be maintained; the palatability is good, the acceptability of pets is high, and the oral disease risk of dogs and cats can be reduced.

The invention relates to a non-invasive life data monitoring method and system based on an intelligent tooth socket, and belongs to the technical field of health monitoring. The method comprises the following steps: acquiring non-invasive life data, obtaining non-invasive life quantification data according to the non-invasive life data, and constructing a multi-modal non-invasive life monitoring set according to the non-invasive life quantification data; according to the multi-modal non-invasive life monitoring set, obtaining a tooth pathological model through chewing and occlusion dynamic simulation; non-invasive life real-time monitoring data is obtained, a tooth pathology label is obtained through the tooth pathology model according to the non-invasive life real-time monitoring data, an orthodontic personalized correction scheme and a health intervention strategy are generated according to the tooth pathology label, and the tooth health condition is accurately recognized. Therefore, the chewing habit of the user is improved, and occurrence and development of oral diseases are prevented.

The present invention relates to an oral care composition comprising a peptidase or lactonase, preferably a peptidase and a lactonase, use of said composition in medicine, use of said composition in treatment of oral disease, methods of treatment comprising administering said composition to a human subject, methods of preventing or removing oral biofilm comprising contacting an oral biofilm with said composition, methods for reducing the risk of oral biofilm formation, and kits of parts comprising said composition.

The invention discloses a formula and a production method of toothpaste capable of inhibiting odontitis. The toothpaste comprises the following raw materials: an abrasive, a thickening agent, a preservative, an active additive, a humectant, a foaming agent, a traditional Chinese medicine mixture and deionized water, the proportions of the raw materials are as follows: 50% of the friction agent, 3.5% of the thickening agent, 0.5% of the preservative, 1% of the active additive, 15% of the humectant, 2.5% of the foaming agent, 5% of the traditional Chinese medicine mixture and the balance of deionized water; during tooth brushing, foam generated during tooth brushing covers the traditional Chinese medicine components on teeth and gingiva, through the traditional Chinese medicine components in the toothpaste, the effects of clearing away heat and toxic materials, helping produce saliva and slake thirst, diminishing inflammation and inhibiting bacteria are achieved, and the components are non-irritant, do not generate drug resistance and do not have toxic or side effects on a human body; in the tooth brushing and mouth rinsing process, foam generated by the toothpaste can be mixed with the mouth rinse to generate a trace amount of mouth rinse, so that oral bacteria can be effectively inhibited, bad breath can be removed, the toothpaste has a good oral cleaning and nursing effect, and meanwhile, the occurrence and development of oral diseases are prevented.

The present invention relates to a novel Lactobacillus acidophilus strain. Also, the present invention relates to uses of the Lactobacillus acidophilus strain for antibacterial activity, antioxidation, the suppression of periodontal tissue damage or degradation, and anti-inflammation. Also, the present invention relates to a composition comprising the Lactobacillus acidophilus strain. The Lactobacillus acidophilus strain of the present invention can exhibit antibacterial activity against oral harmful bacteria that cause oral diseases, suppress the production of reactive oxygen species (ROS), inhibit the expression or activity of matrix metalloproteinase-3 (MMP-3) that causes periodontal tissue damage or degradation, and inhibit the expression or activity of inflammatory cytokines IL-6 and IL-8. Therefore, the strain and the composition comprising same, of the present invention, can be effectively used for antibacterial activity, antioxidation, the suppression of periodontal tissue damage or degradation, and anti-inflammation, and can also be used for treating, ameliorating or preventing oral diseases.

The invention provides an intelligent management system for oral health detection, and the system comprises a data collection module which is used for inputting the personal information of a user, and detecting the oral information of the user through an oral detection device; the data warehouse module is used for storing data in a five-dimensional classification manner according to gender, age, region, activeness and tooth health state; the user classification module is used for generating user health portrait labels through a clustering algorithm; and the intelligent analysis module is used for carrying out differential data analysis based on the user health portrait tag and issuing a data analysis report. The oral health in the region is combined according to the user health portrait label, personal health management and regional public health early warning are combined, data information can be transmitted to the cloud, doctors can conveniently know the oral condition of the user, early warning of high-incidence regions of oral diseases such as decayed teeth can be achieved, targeted treatment can be carried out in time, and the user experience is improved. The oral health of the public can be conveniently improved.

The present invention relates to compositions for oral hygiene comprising Crocus sativus flower extracts and their uses for protecting the oral cavity. The invention also relates to therapeutic compositions for use in the prevention and treatment of diseases of the oral cavity, in particular periodontitis and gingivitis.

The present invention relates to an oral care composition comprising a peptidase or lactonase, preferably a peptidase and a lactonase, use of said composition in medicine, use of said composition in treatment of oral disease, methods of treatment comprising administering said composition to a human subject, methods of preventing or removing oral biofilm comprising contacting an oral biofilm with said composition, methods for reducing the risk of oral biofilm formation, and kits of parts comprising said composition.

The invention relates to a composition for improving gingivitis, a preparation method of the composition and gargling and relates to the technical field of gingivitis, and the composition for improving gingivitis comprises the following components in parts by weight: 20-40 parts of shiny-leaved yellowhorn leaves, 5-15 parts of peach gum and 10-25 parts of humulus lupulus. The shiny-leaved yellowhorn leaves, the peach gum and the humulus lupulus which can be used as both medicines and foods are matched to be used as functional raw materials, and meanwhile, effective components are extracted by combining a modern supercritical carbon dioxide extraction process under proper parameters, so that the treatment effect of the obtained composition on gingivitis diseases is remarkably improved, and the use safety of patients is greatly improved. On the basis, the invention further provides the suhuang capable of improving oral diseases such as gingivitis, and the suhuang has the advantages of being safe, effective and the like and is wide in application prospect.

The invention relates to the field of pet food, in particular to a traditional Chinese medicine composition, a preparation method thereof and application of the traditional Chinese medicine composition in pet oral care. The invention discloses a traditional Chinese medicine food additive for dog oral care. The traditional Chinese medicines are medicinal and edible traditional Chinese medicines and comprise centella asiatica extract, mint extract and aloe extract. The components act together and are integrally suitable for dog oral care. Efficacy tests prove that the dog oral care solution can effectively promote dog oral health, inhibit dog oral saliva colonies, reduce the hydrogen sulfide content in dog oral cavities, relieve ozostomia, maintain fresh breath, reduce the risk of dog oral diseases and realize the comprehensive effect of dog oral care. The traditional Chinese medicine additive is good in palatability and high in acceptability of pets, can be directly eaten, can also be sprayed on dog food to prepare dog food with an oral care effect, and has high application value.

The present invention relates to a compound of formula (I) or a salt thereof, wherein the group R is as defined in the specification; and also relates to a method for preparing the compound and its use as a photosensitizer in photodynamic therapy. The monosubstituted protoporphyrin derivatives involved in the present invention all have high permeability, high activity, and good biosafety. The preparation method is simple, low-cost, and can obtain the target product in good yield. It is particularly suitable for industrial production and can be used as a highly effective photosensitizer in photodynamic therapy to treat oral diseases such as periodontitis, gingivitis, dental plaque, and caries caused by Gram-negative anaerobic cocci and other bacteria such as Porphyromonas gingivalis.

The invention discloses an antibacterial peptide and application thereof in preventing and treating dental plaque and gingival problems, and belongs to the technical field of biology. According to the invention, two cationic antibacterial peptides LR18 and LR18-2 with amphiphilic alpha-helical structures are designed from the beginning. The two antibacterial peptides have good antibacterial and bactericidal activity on oral periodontal pathogenic bacteria (including fusobacterium nucleatum, porphyromonas gingivalis and streptococcus mutans), the minimum inhibitory concentration (MIC) is 62.5-500 [mu] g / mL, and the minimum bactericidal concentration (MBC) is 62.5-2000 [mu] g / mL. The structure is simple, the chemical synthesis difficulty is low, a high-purity product can be directly synthesized, the cell hemolytic activity is low, the safety is high, the product can be used for preparing oral antibacterial drugs and / or oral care products, and oral diseases are prevented and treated by inhibiting the growth of oral periodontal pathogenic bacteria.

Disclosed are a novel Streptococcus salivarius (S. salivarius G7, KCCM13161P) strain, a composition containing the same for prevention or alleviation of an oral disease, and oral probiotics, and specifically, the novel Streptococcus salivarius (S. salivarius G7, KCCM13161P) strain can prevent, treat, and alleviate periodontal diseases through strong antibacterial and antiinflammatory activities against periodontal disease-causing strains, prevents, treat, and alleviates dental caries through strong antibacterial activity against dental caries-causing strains and biofilm formation inhibitory ability, and suppress halitosis caused by oral diseases, thereby contributing to oral health improvement.

Disclosed herein are methods of identifying a companion animal as being at risk of oral disease or condition comprising obtaining a plaque sample from a tooth of the companion animal; determining a relative abundance of each of positive effect microbiotic species, negative effect microbiotic species, early colonizers, late colonizers, and positive effect phyla in the first plaque sample; and calculating a Tooth Microbiome Gingival Index (TMGI) score. Also disclosed herein are methods of determining whether a pet food composition improves the oral health of a companion animal, methods for preventing or treating an oral disease or condition in a companion animal, and kits for identifying a companion animal as being at risk of an oral disease or condition.

The present invention relates to a Lactobacillus rhamnosus strain. In particular, the present invention relates to a composition comprising a Lactobacillus rhamnosus optionally in combination with a further lactobacilli and the use of the same in the treatment, prevention or alleviation of candidiasis.

The embodiment of the invention discloses a bioactive peptide with an oral cavity anti-aging effect and application of the bioactive peptide. A series of experiments prove that the bioactive polypeptides IR-11 and PK-11 have remarkable anti-inflammatory efficacy, barrier repair efficacy and anti-oxidation and anti-aging efficacy, can be applied to prevention or treatment of chronic inflammatory oral diseases and oral weakness symptoms represented by periodontitis, and show good development and application prospects.

The presently disclosed subject matter relates to compositions and methods for preventing and / or treating of an oral disease and / or a biofilm-associated disease. In particular, the presently disclosed subject matter provides a composition for preventing and / or treating of an oral disease comprising (a) one or more iron oxide nanoparticles and (b) stannous fluoride (SnF2) that provide synergistic properties, including enhanced solubility, stability, co-delivery and catalytic activity, while creating a protective antibacterial and anti-demineralization layer on the target surface for disease prevention.

The invention discloses a composition for preventing and treating oral diseases or conditions, a preparation method and application thereof. The external vesicles based on oral pathogenic bacteria are rich in nano-scale vesicles of immune activation and defense factors aiming at periodontitis, and after the external vesicles enter a body through oral mucosa administration, the external vesicles are passively targeted into lymph nodes related to the oral mucosa to induce mucosa immune specific antibody expression, so that the immune defense capacity to the pathogenic bacteria is improved. Preferably, a calcium phosphate shell is coated outside the oral bacterial outer vesicle, and the calcium phosphate shell can only be dissolved under an acidic condition, so that the engineered vesicle can be degraded after targeting to lymph nodes and being phagocytosed into dendritic cell lysosome, and the inflammatory reaction of a drug delivery area is avoided. The administration form of the sublingual disintegrating tablet can improve the bioavailability of the vaccine while local mucosal administration activates mucosal immunity, and the convenient administration form is also beneficial to the promotion and popularization of the periodontitis vaccine in clinical chair-side diagnosis and treatment or grassroots communities.