6 results about "Protoporphyrin" patented technology

This invention discloses a multifunctional Pediococcus pentosaccharide strain and its applications. Pediococcus pentosaceus The strain, named *Pediococcus pentosaceus* A07, has the accession number CCTCC NO: M 2025777 and is deposited at the China Center for Type Culture Collection (CCTCC), located at Wuhan University, No. 299 Bayi Road, Wuchang District, Wuhan City, Hubei Province. This strain is capable of degrading nitrite. Using *Pediococcus pentosaceus* A07 to reduce nitrite content can produce high-quality pickles with good flavor and texture, low nitrite content, and high viable cell count. The *Pediococcus pentosaceus* A07 provided by this invention also possesses cholesterol-lowering, zinc protoporphyrin-forming, antibacterial, and antioxidant capabilities, and produces a high biofilm.

The invention discloses staphylococcus equorum with high zinc protoporphyrin yield and application of a color former thereof in meat product processing, and belongs to the technical field of meat product processing and microorganisms. In order to solve the technical problems that nitrate or nitrite is used as a color former in the existing meat product processing process, and both the nitrate and the nitrite are harmful to human bodies, the staphylococcus equi SHBCC D1005 is found to have remarkable zinc protoporphyrin production capacity through screening, and the zinc protoporphyrin is biologically synthesized, so that the yield of the staphylococcus equi SHBCC D1005 is increased, and the yield of the staphylococcus equi SHBCC D1005 is increased. An excellent color development effect can be achieved in meat product processing; in addition, it is found that when the strain is prepared into a color former to be applied to meat product processing, nitrite can be effectively replaced, the color quality of meat products is guaranteed, and meanwhile potential health hazards caused by nitrite are avoided. The color former provided by the invention is simple and convenient in preparation process, free of toxic risk and high in safety, provides a safe and efficient biological color development solution for meat product processing, and has remarkable food safety improvement value and industrial application prospect.

The invention relates to a compound and a preparation method thereof, a modular polypeptide nano vaccine and a preparation method and application thereof, and relates to the field of medicines, and the chemical structural formula of the compound is shown as a formula I. The compound provided by the invention contains an mPEG-PLA structure, a protoporphyrin structure chelated with cobalt ions, a beta-cyclodextrin structure and the like, so that the compound is endowed with excellent binding capacity with polypeptide and excellent loading capacity with an adjuvant, and co-delivery of the polypeptide and the adjuvant is realized. On the basis, the invention also provides a modular polypeptide nano vaccine, which has the characteristics of high polypeptide loading rate, plug and play and the like, can remarkably inhibit tumor growth in a B16 subcutaneous tumor model, provides an efficient and flexible technical platform for prevention of tumors such as melanoma and clinical transformation of polypeptide vaccines, and has wide application prospects.

This invention belongs to the field of biomedical technology, specifically relating to a Pt 2+ - Carbon dot@protoporphyrin sonodynamic drug delivery system, its preparation method and application, by loading Pt onto the surface of carbon dots 2+ Modification layer, to obtain Pt 2+ After carbon dots are formed, protoporphyrin is loaded onto them to obtain a carbon dot core with Pt loaded on the carbon dot surface. 2+ Modification layer, in Pt 2+ A sonodynamic drug delivery system with a protoporphyrin-modified layer loaded on the outside of the modified layer can be used in anti-tumor drugs to screen liver cancer cells and normal cells. It has good biocompatibility and significant in vivo sonodynamic anti-tumor effects. It can promote the generation of reactive oxygen species, target and remain in the subcutaneous tumor site in vivo for a long time, increase the mortality rate of cancer cells, and inhibit tumor growth. In a 3D constructed in vitro hepatocellular tumor microenvironment model, this drug delivery system still has superior sonodynamic therapeutic effects.

This invention relates to the prevention or treatment of coronavirus infections and flavivirus infections, including ZIKV and DENV, using porphyrin-peptide conjugates. The conjugates comprise (i) a peptide consisting of the amino acid sequence of SEQ ID NO: 1, 2, 3 or 4, or a variant thereof comprising up to 2 amino acid substitutions, deletions or additions relative thereto; and (ii) a porphyrin moiety selected from mesoporphyrin IX or protoporphyrin IX. Methods of treatment and conjugates for use in methods of treatment are provided.

According to the ROS / enzyme dual-responsive nano-drug controlled release system and the preparation method and application thereof, under the dark condition, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and 4-dimethylaminopyridine are dissolved in dichloromethane respectively, protoporphyrin is added, stirring activation is performed, and the ROS / enzyme dual-responsive nano-drug controlled release system is obtained; placing the activation system in an ice-water bath, slowly dropwise adding a hydroxytyrosol solution, transferring to room temperature after dropwise adding, stirring for reaction, and purifying to obtain an intermediate product PPIX-DE; and dissolving the intermediate product PPIX-DE in N, N-dimethylformamide (DMF), mixing with a Tris buffer solution containing dopamine hydrochloride, adjusting the pH value of the system to 8.5, carrying out a stirring reaction at room temperature in a dark place, and after the reaction is finished, carrying out purification treatment to obtain the final product PDAP nanoparticles. Polydopamine (PDA) is used as a carrier and is copolymerized with protoporphyrin (PPIX) modified by hydroxytyrosol (DE) to obtain the polydopamine protoporphyrin nanoparticles (PDAP), so that the stability, the water solubility and the pathogen targeting property of the photosensitizer drug protoporphyrin are improved.