37 results about "Protoporphyrin" patented technology

The invention belongs to the technical field of sensing detection and particularly discloses a method for preparing a field-effect sensor for detecting hydroxyl free radicals. The method disclosed bythe invention comprises the steps: firstly, preparing a conductive graphene film on an insulating substrate, and preparing patterned electrodes so as to obtain a field-effect device; then, plating thesurface of the graphene film with a layer of gold film, and carrying out annealing in an inert gas atmosphere, so as to obtain uniform-distributed gold nanoparticles; finally, modifying surfaces of the gold nanoparticles with protoporphyrin, thereby obtaining a protoporphyrin-gold nanoparticle modified graphene film. By using metal ions such as cadmium ions capable of being coordinated with the protoporphyrin as a current change indicator, and the surface charge concentration of graphene is changed through an oxidated bond breaking action on modified porphyrin by the hydroxyl free radicals, so that the detection on concentration of the hydroxyl free radicals is achieved. According to the field-effect sensor for detecting the hydroxyl free radicals and the preparation method of the field-effect sensor, the process is simple, high-selectivity rapid sensing can be achieved, and a foundation is laid for the application of the field-effect sensor in the fields of lives, environments, energy, safety and the like.

The invention discloses an iron-supplementing compound, which comprises the following components including, by weight, 64-75 parts of organic iron, 2-4 parts of protoporphyrin and 15-18 parts of synergist. The iron-supplementing compound is suitable for livestock giving priority to pigs and poultry. The iron-supplementing compound accelerates red blood cell proliferation, improves hemoglobin synthesis and remarkably improves hematopoiesis effects. A plurality of different organic iron serves as an iron source for hematopoiesis, the iron source is absorbed by an organism to the most extent, reduction states of hemoglobin bivalent iron are protected, optimal working states of red blood cells are maintained, the bivalent iron is protected from failure caused by the fact that the bivalent iron is oxidized into trivalent iron, and maximum absorption of the bivalent iron is guaranteed.

The invention discloses filter additive for reducing nitrosamines in cigarette smoke and application of the filter additive. The filter additive is one of protoporphyrin derivatives. The filter additive with 0.05-10% of carrier weight is suspended in solvent and is sprayed to a carrier, and the carrier with the added protoporphyrin derivative is added to a stranded filter stick in strand forming to make the compound filter. The filter additive has the advantages that the protoporphyrin derivative is provided initially and has an evident effect in lowering content of TSNAs (nitrosamines) in smoke.

The invention relates to a bovine serum albumin modified protoporphyrin/trimanganese tetroxide/carbon oxynitride nano composite material as well as preparation and application thereof. The preparationmethod comprises the following steps: (1) preparing a uniformly dispersed carbon oxynitride nanosheet aqueous solution; (2) sequentially adding manganese acetate tetrahydrate and triethylamine into the carbon oxynitride nanosheet aqueous solution obtained in the step (1), performing continuous stirring, and preparing a trimanganese tetroxide-loaded carbon oxynitride nanomaterial through an in-situ growth method; and (3) loading protoporphyrin to the surface of the trimanganese tetroxide-loaded carbon oxynitride nanomaterial obtained in the step (2) by stirring, and adding bovine serum albuminfor modification. The material prepared by the method disclosed by the invention can be applied to magnetic resonance imaging and tumor sonodynamic therapy. Compared with the prior art, the bovine serum albumin modified protoporphyrin/trimanganese tetroxide/carbon oxynitride nano composite material disclosed by the invention has good biocompatibility and can be used as a magnetic resonance imaging contrast agent to guide sonodynamic therapy of tumors.

The invention provides auxiliary food liver powder for infants. The auxiliary food liver powder for the infants is prepared from the following raw materials in percentages by mass: 60%-75% of mixed liver powder, 15%-30% of galactooligosaccharide and 5%-15% of red date powder. The invention also provides a preparation method of the auxiliary food liver powder for the infants. According to the auxiliary food liver powder for the infants and the preparation method of the auxiliary food liver powder, chicken livers, pork livers and goose livers are used as sources of iron elements, proteins and other nutrient elements, and meanwhile are matched with red dates and galactooligosaccharide. The red dates also contain rich iron elements; the iron elements in the food can be directly absorbed by intestinal mucosa cells and are changed into protoporphyrin and iron ions through intracellular enzymes; and the iron ions enter blood and have small irritation to gastrointestinal tracts. Meanwhile, thegalactooligosaccharide is added and can improve the digestion and absorption functions of human intestinal tracts, promote the digestion and absorption of intestinal tracts of the infants to the ironions and other nutrient elements and have a protection effect on the gastrointestinal tracts.

The invention provides a preparation method of a chitosan nano material (CMCS-PEI-PpIX nano particle) with high stability and high biological safety and an application of the chitosan nano material in broad-spectrum photodynamic microbe resistance. The preparation method comprises the following steps: taking protoporphyrin (PpIX) and ethyleneimine (PEI) as raw materials, and obtaining PEI-PpIX through a one-step hydrothermal method. Then, the PEI-PpIX and carboxymethyl chitosan (CMCS) are used as raw materials, and CMCS-PEI-PpIX with negative charges is generated through EDC/NHS reaction. The CMCS-PEI-PpIX is self-assembled into nano particles in a solution, and shows a remarkably enhanced singlet oxygen yield in the solution. Therefore, the CMCS-PEI-PpIX nanoparticles have very good antibacterial PDT activity on gram-negative bacteria, gram-positive bacteria and fungi, and meanwhile, the CMCS-PEI-PpIX nanoparticles have no toxicity to normal cells and are highly stable. The invention provides an effective way for effectively killing disease microorganisms in food, medical supplies and food and medicine processing environments.

The invention discloses a compound, a water-soluble hematoporphyrin nano-particle and a preparation method and application thereof.The water-soluble hematoporphyrin nano-particle is prepared through a reaction of hemin and 2-methacrylic acid, the hemin is a complex formed by chlorination of ferric ions and protoporphyrin, the T1 longitudinal relaxation time of water protons can be greatly shortened, and the water-soluble hematoporphyrin nano-particle can be used for preparing the water-soluble hematoporphyrin nano-particle. The contrast enhancement effect is shown, so that the contrast agent can be used as a contrast agent; meanwhile, ferric ions are tightly combined with protoporphyrin and are not easy to dissociate, so that the problem of toxic hidden danger of a contrast agent is effectively avoided.

The invention discloses protoporphyrin lipidosome for nuclear delivery of chemotherapeutic drugs and a preparation method and application of the protoporphyrin lipidosome. The protoporphyrin lipidosome is mainly prepared from hydrogenated soybean lecithin, distearoyl phosphatidylethanolamine-polyethylene glycol 2000, cholesterol and protoporphyrin. The liposome can be prepared by a film hydrationmethod and further ultrasonic or extrusion treatment, and can wrap various chemotherapeutic drugs to form protoporphyrin liposome loaded chemotherapeutic drugs so as to realize in-vivo long circulation and tumor delivery of the drugs. Moreover, compared with the traditional liposome, the liposome can increase the cell nucleus distribution of the chemotherapeutic drug, realizes more efficient cellnucleus drug delivery and cell killing, has good safety and good universality, and is expected to become a universal chemotherapeutic drug cell nucleus delivery carrier.

The present invention provides a self-assembled nanomaterial and its preparation method and application. The raw materials of the nanomaterial include nucleic acid molecules, aminoglycoside molecules and metal protoporphyrin; the self-assembled nanomaterial provided by the present invention uses aminoglycoside molecules As an activator, the nanomaterial prepared by co-assembly with nucleic acid molecules and metal protoporphyrin, as a simulated enzyme catalyst, has the same order of magnitude of substrate turnover and catalytic efficiency as natural horseradish peroxidase. Because aminoglycoside molecules and metal protoporphyrin, nucleic acid metal protoporphyrin conjugates or nucleic acid metal protoporphyrin self-assembly, aminoglycoside molecules and nucleic acids have a synergistic effect on the catalytic activity of metal protoporphyrin, and have a more High catalytic activity; high application value in chemical sensors and biosensors.