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2 results about "Protoporphyrin" patented technology
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Protoporphyrins are tetrapyrroles containing the following side chains: methyl propionic acid vinyl Protoporphyrin IX is a biochemically widely used carrier molecule for divalent cations. Together with iron the body of the heme- group of hemoglobin, myoglobin and many other heme-containing enzymes like cytochrome c and catalase are formed. Complexed with magnesium-ions the main part of the Chlorophylls are formed. Complexed with zinc-ions it forms Zinc protoporphyrin. The number indicates the position of different side chains, but historically, as the nomenclature has grown, it has done so systematically only in parts. Protoporphyrin IX as a direct precursor of heme is accumulated by patients of erythropoietic protoporphyria, which is one of the genetic disorders of the biosynthesis of the heme -pathway. It causes a severe photosensivity against visible light. The sensitivity of protoporphyrin IX against light is also used as a therapy against different forms of cancer. Protoporphyrins are deposited in the shells of the eggs of some birds as a brown or red pigment, either as a ground colour or as spotting.
A type of Pt 2+ - Carbon dot@protoporphyrin sonodynamic drug delivery system, its preparation method, and applications
ActiveCN117462678BNanomedicinePharmaceutical non-active ingredientsTherapeutic effectBiocompatibility
This invention belongs to the field of biomedical technology, specifically relating to a Pt 2+ - Carbon dot@protoporphyrin sonodynamic drug delivery system, its preparation method and application, by loading Pt onto the surface of carbon dots 2+ Modification layer, to obtain Pt 2+ After carbon dots are formed, protoporphyrin is loaded onto them to obtain a carbon dot core with Pt loaded on the carbon dot surface. 2+ Modification layer, in Pt 2+ A sonodynamic drug delivery system with a protoporphyrin-modified layer loaded on the outside of the modified layer can be used in anti-tumor drugs to screen liver cancer cells and normal cells. It has good biocompatibility and significant in vivo sonodynamic anti-tumor effects. It can promote the generation of reactive oxygen species, target and remain in the subcutaneous tumor site in vivo for a long time, increase the mortality rate of cancer cells, and inhibit tumor growth. In a 3D constructed in vitro hepatocellular tumor microenvironment model, this drug delivery system still has superior sonodynamic therapeutic effects.
Owner:SHANXI SIX DIMENSIONAL ARTIFICIAL INTELLIGENCE BIOMEDICAL RES INST
Double-responsiveness nano-drug controlled release system based on polydopamine as well as preparation and application of double-responsiveness nano-drug controlled release system
According to the ROS / enzyme dual-responsive nano-drug controlled release system and the preparation method and application thereof, under the dark condition, 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride and 4-dimethylaminopyridine are dissolved in dichloromethane respectively, protoporphyrin is added, stirring activation is performed, and the ROS / enzyme dual-responsive nano-drug controlled release system is obtained; placing the activation system in an ice-water bath, slowly dropwise adding a hydroxytyrosol solution, transferring to room temperature after dropwise adding, stirring for reaction, and purifying to obtain an intermediate product PPIX-DE; and dissolving the intermediate product PPIX-DE in N, N-dimethylformamide (DMF), mixing with a Tris buffer solution containing dopamine hydrochloride, adjusting the pH value of the system to 8.5, carrying out a stirring reaction at room temperature in a dark place, and after the reaction is finished, carrying out purification treatment to obtain the final product PDAP nanoparticles. Polydopamine (PDA) is used as a carrier and is copolymerized with protoporphyrin (PPIX) modified by hydroxytyrosol (DE) to obtain the polydopamine protoporphyrin nanoparticles (PDAP), so that the stability, the water solubility and the pathogen targeting property of the photosensitizer drug protoporphyrin are improved.
Owner:WUHAN POLYTECHNIC UNIVERSITY +1