3872 results about "Structural formula" patented technology

The invention discloses long-chain alkyl polyarylamine as well as a preparation method and application thereof. The structural formula of the long-chain alkyl polyarylamine is as shown in a formula (I): # imgabs0 # formula (I), wherein R is an alkyl group with the carbon atom number of 5-12, the weight-average molecular weight of the R is 5000-136000 g / mol, and the PDI of the R is 1.41-2.24; the long-chain alkyl polyarylamine provided by the invention has relatively high fluorescence intensity, can stably emit fluorescence at high temperature and under long-term illumination, and has relatively long fluorescence lifetime.

The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula I.or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and / or prevention of physiological conditions associated with CRM1 activity.

The invention discloses erianin PROTACs as well as a preparation method and application thereof, the structural formula of the erianin PROTACs is # imgabs0 #, E3 Ligand is pomalidomide, and Linker is an alkane chain or a PEG chain. The erianin PROTACs disclosed by the invention are superior to the prior art in the aspects of target protein degradation efficiency, anti-tumor activity, innovativeness, application prospect and the like, and show remarkable technical progress and practical value.

The invention discloses a molecular probe for in-vivo copper ion detection and a preparation method and application thereof, the chemical structural formula of the molecular probe is as follows: # imgabs0 #, the molecular probe provided by the invention can specifically respond to copper ions in a tumor subacid environment so as to cause change of an absorption spectrum, and a photoacoustic signal is started so as to detect the copper ions in the tumor subacid environment. Normal tissues and tumor tissues can be accurately distinguished, and accurate detection of the copper ions in the living tumor is realized.

The present application relates to a various novel crystalline forms of 2- [3,5-dichloro -4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy) phenyl]-3,5- dioxo- 2,3,4,5-tetrahydro [1,2,4] triazine-6-carbonitrile represented by the following structural formula-1, which is referred to as Resmetirom. The present application also relates to process for the preparation of various novel crystalline polymorphic forms of compound of formula-1.

The invention discloses a beta-lactoglobulin fluorescent probe as well as a preparation method and application thereof, the structural formula of the probe is (C30H25N4I), the probe is combined with beta-lactoglobulin through non-covalent interaction, a fluorescence signal is triggered to be remarkably enhanced, and low-background fluorescence detection of the beta-lactoglobulin is realized. The probe has low cytotoxicity and excellent mitochondrial targeting ability, and provides a powerful tool for visualization of beta-lactoglobulin in living cells. After being combined with beta-lactoglobulin, a sample can generate obvious color change under the irradiation of an ultraviolet lamp, and the change can be used for evaluating the content of active beta-lactoglobulin in the sample, so that the rapid detection of the milk protein level in a beverage is realized. The beta-lactoglobulin fluorescent probe disclosed by the invention has a wide application prospect in the fields of biological imaging, milk protein detection, beverage quality control and the like.

The invention discloses an indole-benzothiadiazole derivative as well as a preparation method and application thereof. The general structural formula of the indole-benzothiadiazole derivative provided by the invention is shown in the specification, wherein R is selected from one of methyl piperazinyl, diethylamino, azetidinyl and pyrrolidinyl. The derivative can be specifically combined and fluorescently labeled with mitochondrial RNA in cells, and has good selectivity, high fluorescence signal-to-noise ratio and excellent anti-interference capability in a complex biological system. Meanwhile, the indole-benzothiadiazole derivative provided by the invention is simple in synthetic route, easily available in raw materials, good in stability and convenient to store and use, can be specifically combined with RNA and generate strong fluorescence response, is suitable for real-time detection and imaging of in-vitro and in-vivo mitochondrial RNA, and is an efficient mitochondrial RNA micromolecular fluorescent probe.

The invention relates to a (methyl) acrylate monomer as well as a preparation method and application thereof, the structural general formula of the (methyl) acrylate monomer is as follows: # imgabs0 #, n is an integer of 1-20, and R1 is methyl or hydrogen; r2 and R3 are selected from hydrogen, Br, phenyl, methyl or # imgabs 1 #, wherein A1 in the # imgabs 2 # is phenyl or methyl. According to the (methyl) acrylate monomer provided by the invention, the molecular size of the whole monomer is relatively small, the whole monomer has a plurality of branched chain structures, the carbon chain length of a main chain is controllable, and the (methyl) acrylate monomer has high refractive index and good intermiscibility with other components.

The invention provides a dihydroquercetin caffeine eutectic crystal and a preparation method and application thereof, and belongs to the technical field of eutectic crystal manufacturing. The structural formula of the dihydroquercetin caffeine eutectic crystal is as shown in formula I. The dihydroquercetin caffeine eutectic crystal has excellent water solubility, so that the dihydroquercetin caffeine eutectic crystal has ideal compatibility and bioavailability.

The invention relates to the technical field of biological medicine, in particular to a ferroptosis inhibition type phospholipid-like material and application thereof. The ferroptosis inhibition type phospholipid-like material is one of the following structural general formulas (1)-(5). The biomimetic phospholipid-like ferroptosis inhibitor has a long retention characteristic in main positions (cell membranes, endoplasmic reticulum and other organelle membranes) of cell ferroptosis, so that the ferroptosis inhibition efficiency is remarkably improved. The novel phospholipid-like material not only can be used as an active drug molecule, but also can be used as a pharmaceutic adjuvant for constructing drug delivery carriers such as lipidosome and micelle and implant coatings, and is suitable for various administration routes such as oral administration, injection and local administration. The novel biomimetic ferroptosis inhibitor can efficiently relieve cell ferroptosis and has a wide application prospect in the field of treating or retarding ferroptosis-related diseases.

The present invention relates to crystalline forms of the compound represented by Structural Formula I, and compositions comprising crystalline forms of the compound represented by Structural Formula I described herein. The crystalline forms of the compound of Structural Formula I and compositions comprising the crystalline forms of the compound of Structural Formula I provided herein, in particular, single crystalline Form A, can be incorporated into pharmaceutical compositions, which can be used to treat various disorders associated with CRM1 activity, including cancer. Also described herein are methods for preparing the compound of Structural Formula I and its single crystalline forms.

The invention discloses a long-chain alkyl polyarylamine composite material with fluorescence characteristics and application thereof, the long-chain alkyl polyarylamine composite material comprises long-chain alkyl polyarylamine and polyolefin in a mass ratio of 1: 19-1000, and the structural formula of the long-chain alkyl polyarylamine is as shown in the formula (I): # imgabs0 # formula (I); wherein R is an alkyl group with the carbon atom number of 5-12, the weight-average molecular weight of the R is 5000-136000 g / mol, and the PDI of the R is 1.41-2.24; the long-chain alkyl polyarylamine and the polyolefin are blended to prepare the composite material, the problem of poor mixing dispersity of a fluorescent substance and the polyolefin is solved, and the obtained composite material has high fluorescence intensity and can be potentially applied to the fields of display, light conversion films, fluorescence positioning and the like.

The invention discloses a radionuclide labeled molecular probe for detecting collagen structure denaturation and a preparation method and application thereof, and relates to the technical field of biology. The structural general formula of the radionuclide labeled molecular probe disclosed by the invention is as follows: K (chelating agent-nuclide)-K-Linker-CHP, wherein K (chelating agent-nuclide) is a lysine residue labeled by a side chain amino coupling chelating agent and a radionuclide; the Linker is a connection joint; cHP is a collagen hybrid peptide with a polypeptide sequence of (GfO) n or (GPO) n. The probe has excellent definition and signal-to-noise ratio, not only can detect pancreatic ductal adenocarcinoma in a pancreatic cancer model, but also can sensitively detect precancerous lesions (such as pancreatic intraepithelial neoplasia lesions) of the pancreatic ductal adenocarcinoma and pulmonary fibrosis lesions in a bleomycin pulmonary fibrosis model. And the kit has important significance on early detection of pancreatic duct adenocarcinoma and reflection of dynamic change of ECM remodeling.

The invention belongs to the technical field of biochemical engineering, and particularly relates to an amitriptyline hapten and a preparation method thereof, an amitriptyline antigen and a preparation method thereof, an antibody, a kit and application. The amitriptyline hapten has a structural formula shown as a formula (I) or a formula (II). Compared with an existing structure, the amitriptyline hapten prepared by the invention has a better immune effect. The obtained antibody is high in titer, strong in specificity and high in affinity, the LOD of amitriptyline by using an Elisa method established by the antibody is 0.013 ng / mL, the IC50 of amitriptyline is 0.865 ng / mL, the quantitative detection range is 0.07-470.3 ng / mL, the detection sensitivity is high, and the linear range is wide.

The invention provides a spirocyclic expansion monomer, a preparation method thereof and a resin composition. The structural formula of the spirocyclic expansion monomer is as shown in formula I in the specification. The spiro expansion monomer has the advantages of high reaction activity, low shrinkage rate, good compatibility and the like, and the curing volume shrinkage rate of epoxy resin can be reduced through the ring opening effect of the spiro monomer after the spiro expansion monomer is added into an epoxy resin system, so that the curing shrinkage stress is reduced. The invention also provides a resin composition. The resin composition comprises epoxy resin and the spiro-expansive monomer and / or the oligomer of the spiro-expansive monomer. The spiro expansion monomer is applied to an epoxy resin system to prepare a precise fixing adhesive, the shrinkage rate of the adhesive in the curing process can be effectively reduced, so that the curing shrinkage stress is reduced, the coupling precision is improved, and the spiro expansion monomer is mainly applied to the fields of electronic component bonding, optical device bonding and fixing and the like.

The invention relates to a modified polypropylene polymer material, a binder, a negative plate and a battery. The structural formula of the modified polypropylene high polymer material is shown as a formula 1, in the formula 1, R is selected from one of carboxyl, hydroxyl, an ether bond-containing group and an aldehyde group, S is selected from one of C1-C20 alkylamino, cyano and C1-C20 alkyimino, T is selected from one of C1-C20 ester groups and C1-C20 alkenyl, m, n and k are independently selected from integers in the range of 0-100000, and m, n and k are not 0 at the same time. According to the scheme provided by the invention, the structural stability of the negative plate can be ensured, and the battery shows excellent normal-temperature cycle performance and low-temperature discharge performance.

The invention belongs to the technical field of skin care product raw materials, and discloses an oligopeptide compound, a preparation method thereof, a beautifying composition and application. The oligopeptide compound has a structural formula of # imgabs0. The oligopeptide compound provided by the invention contains peptide fragments of antioxidant amino acids such as tyrosine (Tyr), beta-alanine (beta-Ala), cysteine (Cys) and proline (Pro), and the amino acids can directly participate in removal of free radicals or form a stable peptide structure to enhance the antioxidant effect; therefore, the oligopeptide compound with anti-oxidation and physiological repair effects is obtained. Meanwhile, a mild Fmoc route is adopted in the preparation method, the condensation reaction time of each step is short, the production period is greatly shortened, raw materials are convenient to obtain, the process is stable, the quality is controllable, the product yield and purity are high, and large-scale production can be achieved.

The invention relates to a compound, a preparation method, a hole transport layer material, a photovoltaic device and a photovoltaic module. R1 and R4 are respectively and independently selected from amino and derivatives thereof, hydroxyl and derivatives thereof, methoxyl and derivatives thereof, sulfydryl and derivatives thereof, methylthio and derivatives thereof, thiophene groups and derivatives thereof, phosphate groups and derivatives thereof, carboxylic acid groups and derivatives thereof, and sulfonic acid groups and derivatives thereof; r2 and R3 are independently selected from alkyl, a phosphate group and derivatives thereof, a carboxylic acid group and derivatives thereof, a sulfonic acid group and derivatives thereof, and trimethoxysilyl propyl and derivatives thereof. The material is beneficial to improving the photoelectric conversion efficiency of photovoltaic devices and photovoltaic modules.

The invention relates to the technical field of luminescent materials, and discloses an aggregation-induced emission material, nanoparticles as well as a preparation method and application thereof, the structural general formula of the aggregation-induced emission material is as follows: # imgabs0 #, R is selected from one of the following structures: # imgabs1 # aggregation-induced emission material takes a pyridine group as an acceptor unit, and the acceptor unit is selected from one of the following structures: 1 # imgabs2 # aggregation-induced emission material; a carbon-carbon double bond and a thiophene unit are used as pi bridges, and diphenylamine, bis (4-ethylphenyl) amine and bis (4-(tert-butyl) phenyl) amine are used as strong electron donors. The donors not only provide strong electron supply ability, but also become efficient rotors due to highly twisted molecular conformation, and endow the aggregation-induced emission material with long emission wavelength and aggregation-induced emission activity.

The invention provides organic silicon cooling liquid and a preparation method thereof. The molecular structural formula of the organic silicon cooling liquid is shown in the specification, R1 is selected from C3-7alkane, the value of a is 0-12, and the value of b is 14-20. A phenyl group and a long-chain alkyl side chain are introduced into a silicone oil main chain through an organic synthesis means, the regularity of a polysiloxane chain is destroyed, the crystallization property of the polysiloxane chain is reduced, the performance of the organic silicon cooling liquid is changed from the molecular structure, and the organic silicon cooling liquid can still flow at a low temperature (-65 DEG C). In addition, by introducing phenyl, the flash point, irradiation resistance and other properties of the immersed cooling liquid can be remarkably improved. # imgabs0 #

The invention discloses a preparation method of a grafted and substituted thiophene polymer material, which comprises the following steps: mixing poly (3-hexylthiophene), a grafting monomer, a catalyst and an auxiliary agent, and heating for reaction to obtain the grafted and substituted thiophene polymer material, the structural formula of the grafting monomer is as shown in formula (I); wherein B is fluorine, chlorine, bromine or iodine, A is a carbon atom or a nitrogen atom, and R is cyano, formyl, methoxycarbonyl or; according to the method, pre-synthesis of complex functional monomers is avoided, the main chain of the poly (3-hexylthiophene) can be directly modified without using an expensive catalyst or ligand, the polymerization reaction of the poly (3-hexylthiophene) is not interfered, and meanwhile, the method has the advantages of simplified steps and low cost.

The invention discloses a composite collecting agent and a preparation method and application thereof, and relates to the technical field of solid waste recycling. The composite collecting agent comprises a main agent, an auxiliary agent and a synergist, and the mass ratio of the main agent to the auxiliary agent is (3-1): (1-2). The mass of the synergist is 0.1%-2.5% of the total mass of the composite collecting agent; the structural formula of the main agent is as shown in formula (I): R-O-C (= S)-NH-R '(I); in the formula (I), R is alkyl, and R'is 3-chloro-1, 2-epoxypropane; the auxiliary agent is a mercaptobenzothiazole derivative. The thiocarbamate and the mercaptobenzothiazole derivative are compounded according to a specific proportion for the first time, a Zn-S shielding layer is destroyed through an intermolecular synergistic effect, and the silver recovery rate is increased; the preparation method is simple and easy to operate, facilitates reduction of the dosage of a single agent and reduces environmental pollution. The foam stability is improved, the flotation efficiency is improved, the selective collection efficiency of the silver-zinc ore is remarkably improved, and the flotation index is improved.

The invention provides an anion exchange polymer and a preparation method thereof and an anion exchange membrane, the anion exchange polymer comprises a chain segment I and / or a chain segment II, the structural formula of the chain segment I is # imgabs0 #, the structural formula of the chain segment II is # imgabs1 #, A is nitrogen-containing heterocyclic ketone, Ar1 is a first aryl structural unit, Ar2 is a second aryl structural unit, and the structural formula of the chain segment II is # imgabs1 #. M <-> is a trifluoroacetic acid ion and / or a p-toluenesulfonate ion. The anion exchange polymer disclosed by the invention is relatively low in toxicity to a catalyst, so that the anion exchange polymer shows excellent electrochemical performance.

The invention discloses a palladium catalyst as well as a preparation method and application thereof. The structural formula of the palladium catalyst is shown as a formula (I), according to the invention, an alkoxy group is introduced into the skeleton of the palladium catalyst and N-methylimidazole is coordinated with palladium, so that the catalytic yield of the palladium catalyst is effectively improved, and long-chain alkyl polyarylamine with high molecular weight and narrow distribution is obtained; the method does not need to use a traditional phosphine ligand, avoids potential hazards of phosphine compounds to operators and the environment in the use process, and is expected to be industrially applied on a large scale due to the fact that the phosphine compounds are stable to air and moisture and can be stored for a long time.

The invention discloses a method for detecting melogabalin besylate and isomer impurities of melogabalin besylate. According to the method, liquid chromatography is adopted, an FXAA reagent and a sample to be tested are subjected to a reaction under the alkaline condition to obtain a solution to be detected, then the solution to be detected is subjected to liquid chromatography separation, the structural formula of the FXAA reagent is # imgabs0 #, R is selected from-CH (CH3) 2,-CH2CH2SCH3 or-C6H5, and the structural formula of the FXAA reagent is as shown in the specification, the structural formula of the FXAA reagent is as shown in the specification, and the structural formula of the FXAA reagent is as shown in the specification, the structural formula of the FXAA reagent is as shown in the specification, the structural formula of the FXAA reagent is as shown in the specification, and the structural formula of the FXAA reagent is as shown in the specification. The test sample comprises melogabalin besylate and isomer impurities thereof, and the liquid chromatography adopts a reversed-phase chromatographic column. According to the method, melogabalin besylate and three isomer impurities thereof can be safely and effectively separated and respectively detected, the detection sensitivity, repeatability and durability are good, and a powerful guarantee is provided for quality control of the medicine.

The invention belongs to the technical field of specific fluorescent probe detection, and particularly relates to a near-infrared fluorescent probe for detecting hydrazine hydrate as well as a preparation method and application of the near-infrared fluorescent probe. The structural formula of the near-infrared fluorescent probe is # imgabs0. The invention provides a preparation method for synthesizing the probe by taking xanthene dye and acetyl chloride as raw materials. By researching the fluorescence spectrum of the fluorescent probe, the selectivity of the probe on N2H4 is evaluated, the fluorescence intensity of the probe is determined to be obviously enhanced only in the presence of N2H4, and the fluorescence intensity is positively correlated with the concentration of N2H4; meanwhile, the probe has the characteristics of quick response and near-infrared emission; the fluorescent probe disclosed by the invention has relatively small cytotoxicity and can be applied to detection of HepG2 cell exogenous hydrazine hydrate.

The invention discloses a (methyl) acrylate monomer, a holographic recording medium, a preparation method and a related device.The structural formula of the (methyl) acrylate monomer is as shown in G1-G5. The preparation method is easy to operate and high in synthesis yield, and further, the holographic recording medium can be applied to holographic recording. The (methyl) acrylate monomer with the structure is introduced into the photopolymer type holographic recording medium, reverse migration of a short polymer chain can be effectively inhibited, and therefore the holographic recording medium with high sensitivity and high diffraction efficiency is obtained, and the invention further provides a preparation method of the holographic recording medium. The invention also provides a volume holographic grating, a holographic optical element and an optical device comprising the holographic recording medium.

The invention discloses a preparation method of methyl phenyl silicone resin. The methyl phenyl silicone resin is prepared by carrying out hydrolysis and polycondensation on methyltrimethoxysilane with a structural formula of CH3S i (OCH3) 3, trimethylmethoxysilane with a structural formula of (CH3) 3S iOCH3, diphenyldimethoxysilane with a structural formula of (C6H5) 2S i (OCH3) 2 and phenyltrimethoxysilane with a structural formula of C6H5Si (OCH3) 3, and adding a solvent. According to the method, acidic wastewater is not generated, treatment with a large amount of cost is avoided, pollution to the natural environment can be reduced, the current green and environment-friendly requirements are met, by-products can be effectively utilized, and the method has good product performance and meets the application requirements.

The invention relates to a tricyclic compound as well as a preparation method and application thereof. The structural formula of the tri-fused ring compound is as shown in formula (I): # imgabs0 #, wherein R1, R2, R3, R4, R5, R6, R7, E, X and Y are as described in the specification. The compound can inhibit PDE3 and PDE4 at the same time, and compared with an existing PDE3 and PDE4 double-target inhibitor, the effect is better.

The invention relates to a brand-new microbial natural metabolite, namely Fcl-8, which is derived from a fermentation solution of Xenorhabdius budapestensis XBD8, and is characterized in that the Fcl-8 is a new microbial natural metabolite, namely Fcl-8, which is derived from the fermentation solution of the Xenorhabdius budapestensis XBD8. The purified Fcl-8 is a snow white flocculent crystal and is very easy to dissolve in water, and the solid state of the purified Fcl-8 is as shown in Figure 1. The chemical structural formula of the Fcl-8 is as shown in a figure 2, the chemical formula is C57H102N14O12, the molecular weight is 1175.78744, and the typical secondary mass spectrum information of the Fcl-8 is as shown in a figure 3. The Fcl-8 is derived from a microbial natural metabolite, is novel in structure and high in biological activity, and has very high potential to be developed into a novel biopesticide.