2033 results about "Structural formula" patented technology

The invention discloses an indole-benzothiadiazole derivative as well as a preparation method and application thereof. The general structural formula of the indole-benzothiadiazole derivative provided by the invention is shown in the specification, wherein R is selected from one of methyl piperazinyl, diethylamino, azetidinyl and pyrrolidinyl. The derivative can be specifically combined and fluorescently labeled with mitochondrial RNA in cells, and has good selectivity, high fluorescence signal-to-noise ratio and excellent anti-interference capability in a complex biological system. Meanwhile, the indole-benzothiadiazole derivative provided by the invention is simple in synthetic route, easily available in raw materials, good in stability and convenient to store and use, can be specifically combined with RNA and generate strong fluorescence response, is suitable for real-time detection and imaging of in-vitro and in-vivo mitochondrial RNA, and is an efficient mitochondrial RNA micromolecular fluorescent probe.

The invention relates to the technical field of biological medicine, in particular to a ferroptosis inhibition type phospholipid-like material and application thereof. The ferroptosis inhibition type phospholipid-like material is one of the following structural general formulas (1)-(5). The biomimetic phospholipid-like ferroptosis inhibitor has a long retention characteristic in main positions (cell membranes, endoplasmic reticulum and other organelle membranes) of cell ferroptosis, so that the ferroptosis inhibition efficiency is remarkably improved. The novel phospholipid-like material not only can be used as an active drug molecule, but also can be used as a pharmaceutic adjuvant for constructing drug delivery carriers such as lipidosome and micelle and implant coatings, and is suitable for various administration routes such as oral administration, injection and local administration. The novel biomimetic ferroptosis inhibitor can efficiently relieve cell ferroptosis and has a wide application prospect in the field of treating or retarding ferroptosis-related diseases.

The invention belongs to the technical field of biochemical engineering, and particularly relates to an amitriptyline hapten and a preparation method thereof, an amitriptyline antigen and a preparation method thereof, an antibody, a kit and application. The amitriptyline hapten has a structural formula shown as a formula (I) or a formula (II). Compared with an existing structure, the amitriptyline hapten prepared by the invention has a better immune effect. The obtained antibody is high in titer, strong in specificity and high in affinity, the LOD of amitriptyline by using an Elisa method established by the antibody is 0.013 ng / mL, the IC50 of amitriptyline is 0.865 ng / mL, the quantitative detection range is 0.07-470.3 ng / mL, the detection sensitivity is high, and the linear range is wide.

The invention provides a spirocyclic expansion monomer, a preparation method thereof and a resin composition. The structural formula of the spirocyclic expansion monomer is as shown in formula I in the specification. The spiro expansion monomer has the advantages of high reaction activity, low shrinkage rate, good compatibility and the like, and the curing volume shrinkage rate of epoxy resin can be reduced through the ring opening effect of the spiro monomer after the spiro expansion monomer is added into an epoxy resin system, so that the curing shrinkage stress is reduced. The invention also provides a resin composition. The resin composition comprises epoxy resin and the spiro-expansive monomer and / or the oligomer of the spiro-expansive monomer. The spiro expansion monomer is applied to an epoxy resin system to prepare a precise fixing adhesive, the shrinkage rate of the adhesive in the curing process can be effectively reduced, so that the curing shrinkage stress is reduced, the coupling precision is improved, and the spiro expansion monomer is mainly applied to the fields of electronic component bonding, optical device bonding and fixing and the like.

The invention relates to a compound, a preparation method, a hole transport layer material, a photovoltaic device and a photovoltaic module. R1 and R4 are respectively and independently selected from amino and derivatives thereof, hydroxyl and derivatives thereof, methoxyl and derivatives thereof, sulfydryl and derivatives thereof, methylthio and derivatives thereof, thiophene groups and derivatives thereof, phosphate groups and derivatives thereof, carboxylic acid groups and derivatives thereof, and sulfonic acid groups and derivatives thereof; r2 and R3 are independently selected from alkyl, a phosphate group and derivatives thereof, a carboxylic acid group and derivatives thereof, a sulfonic acid group and derivatives thereof, and trimethoxysilyl propyl and derivatives thereof. The material is beneficial to improving the photoelectric conversion efficiency of photovoltaic devices and photovoltaic modules.

The invention discloses a preparation method of a grafted and substituted thiophene polymer material, which comprises the following steps: mixing poly (3-hexylthiophene), a grafting monomer, a catalyst and an auxiliary agent, and heating for reaction to obtain the grafted and substituted thiophene polymer material, the structural formula of the grafting monomer is as shown in formula (I); wherein B is fluorine, chlorine, bromine or iodine, A is a carbon atom or a nitrogen atom, and R is cyano, formyl, methoxycarbonyl or; according to the method, pre-synthesis of complex functional monomers is avoided, the main chain of the poly (3-hexylthiophene) can be directly modified without using an expensive catalyst or ligand, the polymerization reaction of the poly (3-hexylthiophene) is not interfered, and meanwhile, the method has the advantages of simplified steps and low cost.

The invention discloses a (methyl) acrylate monomer, a holographic recording medium, a preparation method and a related device.The structural formula of the (methyl) acrylate monomer is as shown in G1-G5. The preparation method is easy to operate and high in synthesis yield, and further, the holographic recording medium can be applied to holographic recording. The (methyl) acrylate monomer with the structure is introduced into the photopolymer type holographic recording medium, reverse migration of a short polymer chain can be effectively inhibited, and therefore the holographic recording medium with high sensitivity and high diffraction efficiency is obtained, and the invention further provides a preparation method of the holographic recording medium. The invention also provides a volume holographic grating, a holographic optical element and an optical device comprising the holographic recording medium.

The invention relates to a brand-new microbial natural metabolite, namely Fcl-8, which is derived from a fermentation solution of Xenorhabdius budapestensis XBD8, and is characterized in that the Fcl-8 is a new microbial natural metabolite, namely Fcl-8, which is derived from the fermentation solution of the Xenorhabdius budapestensis XBD8. The purified Fcl-8 is a snow white flocculent crystal and is very easy to dissolve in water, and the solid state of the purified Fcl-8 is as shown in Figure 1. The chemical structural formula of the Fcl-8 is as shown in a figure 2, the chemical formula is C57H102N14O12, the molecular weight is 1175.78744, and the typical secondary mass spectrum information of the Fcl-8 is as shown in a figure 3. The Fcl-8 is derived from a microbial natural metabolite, is novel in structure and high in biological activity, and has very high potential to be developed into a novel biopesticide.

The invention relates to application of a heterocyclic compound as a fluorescent probe. The structural formula of the heterocyclic compound is shown as a general formula I, and R1, R2, R3, R4, R5, R6, R7 and R8 are independently one of hydrogen, alkyl, hydroxyl, phenyl, hydroxyphenyl, indole and oxymethyl. According to the present invention, the heterocyclic compounds represented by the general formula I can be specifically positioned in mitochondria, and have long fluorescence lifetime, such that the heterocyclic compounds are suitable for being used as mitochondria fluorescence probes.

The invention discloses a novel HIF-2 alpha proteolysis targeting chimera 1 as well as a preparation method and application thereof, the structural formula 1 of the novel HIF-2 alpha proteolysis targeting chimera 1 is shown in the specification, and the obtained novel HIF-2 alpha proteolysis targeting chimera 1 has good proliferation inhibition activity on kidney cancer 786-O cells. The novel HIF-2alpha protein hydrolysis targeting chimera designed by the invention is novel in structure, few in preparation route process steps, easy to obtain raw materials, suitable for industrial production and good in application value.

The invention provides an optical monomer as well as a preparation method and application thereof, the structural general formula of the optical monomer is shown in the specification, in the formula, R1 and R2 are groups with the structural formula shown in the specification; or, one of R1 and R2 is hydrogen, and the other one of R1 and R2 is a group shown in the structural formula; r0 in the group represents hydrogen or methyl. The optical monomer provided by the invention has a (methyl) acrylate group and has the properties of high refractive index and low volume shrinkage; the monomer contains a plurality of aromatic rings with high molar refractive index and low molar volume, sulfur atoms with higher molar refractive index and dibenzothiophene groups with both aromatic rings and sulfur, so that the whole molecule of the monomer has extremely high refractive index, and the whole optical monomer is small in molecular weight and convenient to migrate.

Provided are: a liquid crystal aligning agent which contains two or more polyamic acids and in which deterioration in liquid crystal aligning properties when stored at room temperature is suppressed; a liquid crystal alignment film obtained from the liquid crystal aligning agent; and a liquid crystal display element. The liquid crystal aligning agent is characterized by containing the following polymer (A) and polymer (B). Polymer (A): a polyamic acid (A) having a structural unit derived from a tetracarboxylic acid derivative and a structural unit derived from a diamine, the polyamic acid containing, as the structural unit derived from the tetracarboxylic acid derivative, a structural unit (a-1Ta) represented by formula (1Ta), and containing, as the structural unit derived from the diamine, a structural unit (a-1Da) represented by formula (1Da), at least a part of the terminal of the polyamic acid (A) contains a non-amino group, the non-amino group is a functional group represented by structural formula (E), and the presence rate of the terminal amino group in the polyamic acid (A) is 60% or less based on the total terminal of the polyamic acid (A). Polymer (B): a polyamic acid (B) having a structural unit derived from a tetracarboxylic acid derivative and a structural unit derived from a diamine, the polyamic acid including a structural unit (b-1Tb) represented by formula (1Tb) as the structural unit derived from the tetracarboxylic acid derivative, and including a structural unit (b-1Db) represented by formula (1Db) as the structural unit derived from the diamine. (Definition of each symbol is as defined in the specification) (Definition of each symbol is as defined in the specification) (Definition of each symbol is as defined in the specification) (Definition of each symbol is as defined in the specification)

The invention provides a betaine succinate eutectic crystal as well as a preparation method and application thereof, and belongs to the technical field of eutectic crystal manufacturing. The structural formula of the succinic acid betaine eutectic crystal is shown as a formula I, the molecular formula of the succinic acid betaine eutectic crystal is C28H56N4O16, in the succinic acid betaine eutectic crystal, the molar ratio of succinic acid to betaine is 1: 2, and the succinic acid betaine eutectic crystal has low irritation and excellent effects.

Provided herein are lipid nanoparticles composition comprising a lipid component which comprises: (i) a first lipid wherein the first lipid is an ionizable cationic lipid, (ii) a second lipid wherein the second lipid is separate from the first lipid, (iii) a phospholipid, and (iv) a PEG-lipid wherein the second lipid is a lipid having a structural formula S-I'a, S-I'b, or S-I'c. Also, provided herein is a method of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering an effective amount of the lipid nanoparticle composition disclosed herein.

This application relates to the field of printed circuit board processing technology, and more specifically, to a low-electrical-loss copper bonding compound, its preparation method, and its application. The compound has the following structural formula: a polythiourea molecule with a nitrazole structure, wherein the degree of polymerization n is 3-10. This application benefits from the compound's special structure (C=S and -NH2), effectively achieving bonding under copper-free etching conditions, and the smooth copper surface meets the requirements for high-frequency signal transmission.

The invention discloses a mercury ion detection fluorescent probe based on quinoline as well as a preparation method and application of the mercury ion detection fluorescent probe. The fluorescent probe and a structural formula of the fluorescent probe are shown as a formula I in the specification. A quinoline derivative, namely 2-methyl-7-hydroxyquinoline, is used as a fluorescent chromophore, a thioester group is used as a recognition group, and the prepared fluorescent probe shows high sensitivity and high selectivity on Hg < 2 + > in a solution. The preparation method of the fluorescent probe is simple in steps, raw materials are easy to obtain, and the obtained product is a white flocculent solid, is easy to store, has a wide application prospect and can be produced and applied on a large scale.

The invention belongs to the technical field of drug synthesis, and particularly relates to an adamantane derivative as well as a synthesis method and application thereof. The adamantane derivative comprises an intermediate structural formula I, an intermediate structural formula II and an intermediate structural formula III, and the structural general formula is as follows: Linker is substituted or unsubstituted C6-C10 aroyl, R1 is hydrogen or C1-C6 alkyl, R2 is hydrogen, C1-C6 alkyl or a nitrogen-containing or nitrogen-free structural fragment, or the integral structure of R1R2 is N-substituted heterocyclic pentyl or heterocyclic cyclohexyl. According to the adamantane derivative provided by the invention, an adamantane structure is combined with part of groups of OAB-14, and a parent nucleus structure is changed, so that the drug activity is improved. The invention also provides a synthesis method of the compound, the obtained compound is screened through cell viability research, and the compound has a potential synergistic effect in the aspects of preventing influenza and treating Alzheimer's disease.

Provided are covalent organic frameworks (COFs). Also provided are methods of making the COFs and methods of using the COFs. The COF sheets define a plurality of pores, and stack in an eclipsed configuration to form sheets that assemble to form nanoparticles. Each COF sheet may be a co-condensate of p-phenylenediamine (PA) and (i) triformylbenzene (TFB) and triformylphloroglucinol (TP) or (ii) triformylphloroglucinol (TP). A COF of the present disclosure has the following structure: Formula (I) and / or Formula II where each X2 is Formula (III) where earch X1 is Formula (IV) Formula (V) Formula (VI) Formula (VII) Formula (VIII) Formula (IX) Formula (X) Formula (XI) Formula (XII) Formula (XIII) or any tautomer thereof, where at least one X1 is not Formula (XIV).

The invention belongs to the technical field of pharmaceutical preparations, and relates to a compound I patch composition, a compound I patch and a preparation method thereof. The patch composition comprises the following components in parts by weight: 0.5-12 parts of a pharmaceutical active component, 10-30 parts of a penetration enhancer, 15-56 parts of a crystal inhibitor and 35-57 parts of an acrylic acid pressure-sensitive adhesive, the patch composition also comprises solvent dimethyl sulfoxide and absolute ethyl alcohol, and the residual quantity of the dimethyl sulfoxide is not less than 2.0%; wherein the active pharmaceutical ingredient is a compound I, and the structural formula of the compound I is shown in the specification. According to the patch composition containing the compound I, the medicine stability is high, medicine crystallization and impurity generation are effectively avoided or reduced, and the patch containing the compound I has higher stability and safety; the patch composition containing the compound I has more appropriate drug permeability, so that the patch containing the compound I has higher drug effectiveness.

The invention discloses a dithiocarbamate monomer, a holographic recording medium, a preparation method and a related device, the structural general formula of the monomer is as shown in G1 and G2, R1 represents any one of hydrogen, halogen and C1-C4 alkyl, R3 represents any one of hydrogen, halogen and C1-C4 alkyl, A1 represents C1-C4 alkyl, A2 represents hydrogen or methyl, n is a positive integer, and n = 1-10. The dithiocarbamate monomer provided by the invention has high refractive index, and the holographic recording medium with high sensitivity, high diffraction efficiency and high refractive index modulation degree can be obtained by applying the dithiocarbamate monomer to preparation of the photopolymer holographic recording medium; holographic recording media can be used to prepare volume holographic gratings, holographic optical elements, and optical devices.

The invention relates to the technical field of fullerene derivatives, in particular to a structure-determined fullerene derivative, a structure-determined water-soluble fullerene derivative and preparation methods and applications of the structure-determined fullerene derivative and the structure-determined water-soluble fullerene derivative. The invention provides a fullerene derivative with a determined structure. The structural formula of the fullerene derivative is shown as (VII). The invention also provides a method for preparing the fullerene derivative with the determined structure shown as (VII). The water-soluble fullerene derivative determined by the structure as shown in (VII) provided by the invention has good water solubility and oxidation resistance.

The invention provides an anion-doped perovskite type titanate material and a preparation method and application thereof, the structural formula of the anion-doped perovskite type titanate material is AxByTiOzN1-z, A is an alkali metal element, B is a rare earth element, N is an anion element, 0 lt; x is less than or equal to 1, 0lt; y < = 1, 0lt; z < = 4. The prepared anion-doped perovskite type titanate material is applied to a negative electrode of a lithium ion battery, and compared with a traditional perovskite type titanate material, the anion-doped perovskite type titanate material has better fast charging performance and power characteristics, ultra-long cycle life and excellent safety.

Provided is a compound and so on having aldehyde dehydrogenase 2 (ALDH2) activation effect. A compound, a pharmaceutically acceptable salt of the compound, or a prodrug of the compound or the salt, the compound being represented by the following formula (1):whereinA is a heterocycle,R1 and R2 are each independently hydrogen, an alkyl, an alkenyl, or an alkynyl,R3 is an alkyl, an alkenyl, or an alkynyl, andX1 and X2 are each independently a halogen.

Disclosed in the present invention are a triazine derivative, a preparation method therefor and the use thereof, belonging to the technical field of drug synthesis. Specifically, disclosed in the present invention are a triazine derivative represented by general formula (I), a pharmaceutical composition containing the triazine derivative, and the use thereof in the preparation of an anthelmintic drug for humans or animals. The general structural formula (I) of the triazine derivative is shown as follows. The triazine derivative of the present invention has a significant effect in resisting zoonotic helminths such as nematodes and heartworms, and has a broad application prospect.

The invention discloses an organic silicon cooling liquid and a preparation method thereof, the chemical structural formula of the organic silicon cooling liquid is shown in the following formula (1), (2), (3) or (4), and the organic silicon cooling liquid is prepared by mixing micro-molecular siloxane containing methoxy or ethyoxyl and a single silicon hydrogen reagent containing long-chain alkyl in a solvent and carrying out condensation reaction under the action of a catalyst. Experimental results show that compared with existing organic silicon cooling liquid, the organic silicon cooling liquid has excellent thermal stability, the overall performance of the organic silicon cooling liquid cannot be affected by low polymers or high polymers generated in the reaction process, and the organic silicon cooling liquid has good repeatability in production; the organic silicon cooling liquid has an exact molecular structure, is a single compound, and can be applied to liquid cooling in the fields of data centers and the like, so that the application range of organic silicon molecules with exact structures is expanded; in addition, the preparation method of the organic silicon cooling liquid is simple in post-treatment and relatively low in energy consumption, so that the organic silicon cooling liquid has a wide application prospect.

The invention relates to 3-quinoxalinyl imidazoline thioketone derivatives, a synthesis method and application technical contents. The structural general formula of the derivative is formula 1 or formula 2. The invention provides a preparation method of the derivative. The invention proves that the developed 3-quinoxalinyl imidazoline thioketone derivative has an anti-myocardial hypertrophy effect and can be applied to preparation, research and development of anti-myocardial hypertrophy drugs.

The invention relates to a fluoro-ligand regulated metal organic framework material and a preparation method and application thereof, the fluoro-ligand regulated metal organic framework material is prepared and synthesized by using zirconium oxychloride as a metal node and trimesic acid / 5-fluoroisophthalic acid as an organic ligand through a reflux method; the unit structural formula of the fluorinated ligand metal organic framework material is [Zr6O4 (OH) 4 (BTC) 2-x (F-BTC) x (AA) y (H2O) z], according to the preparation method, trimesic acid and part of 5-fluoroisophthalic acid are co-coordinated, a C-F bond is introduced to regulate and control the electronic environment around a Zr node through deletion of a connecting site, uniform nucleation of crystals is promoted, the grain size of the obtained material is remarkably reduced, and the dispersity is higher.

A hyperbranched polymer and a preparation method therefor and the use thereof. The hyperbranched polymer comprises a structural formula of formula 1, wherein R is selected from a substituted or unsubstituted C12-C18 alkyl. The hyperbranched polymer, which is used as a demulsifier for demulsifying crude oil emulsions, exhibits a high demulsification efficiency, a low usage amount, a low demulsification temperature, a high acid and alkali resistance, and a high salt resistance. The demulsifier has a high demulsification performance in oil-water emulsions with various properties.

A compound having a first ligand LA comprising a structure of Formula I,is provided. In Formula I, moiety B is a monocyclic ring or a polycyclic fused ring system; each of X1 to X6 is C or N; Y is a linking group; K is a direct bond or a linking group; each substituent is hydrogen or a General Substituent defined herein; and at least one of the following conditions is true: (1) an RA substituent is joined with an RB substituent to form a ring AB, which may be substituted by one or more RAB substituents; or (2) X5 and X6 are C, and the corresponding two RA substituents are joined to form a cyclic moiety A1, which may be substituted by one or more RA1 substituents; and moiety B is a polycyclic fused ring system. Formulations, OLEDs, and consumer products containing the compound are also provided.

The invention relates to coacervate-forming polymers having defined structural formulae. The invention also relates solutions comprising the coacervate-forming polymers and methods of making solutions comprising the coacervate-forming polymers. The invention also relates to polymer coacervates, comprising the coacervate-forming polymers within the coacervates, including polymer coacervates comprising cargo compounds, and methods for making such polymer coacervates. The coacervates of the invention are capable of penetrating into cells and thereby delivering cargo compounds into cells. The invention further relates to compositions, including pharmaceutical compositions, comprising the polymer coacervates. The invention also relates to uses of the coacervate-forming polymers, including medical uses.