5539 results about "Methionine" patented technology

A method of thermally processing a tobacco material is provided, the method including the steps of (i) mixing a tobacco material, water, and an additive selected from the group consisting of lysine, glycine, histidine, alanine, methionine, glutamic acid, aspartic acid, proline, phenylalanine, valine, arginine, di- and trivalent cations, asparaginase, saccharides, phenolic compounds, reducing agents, compounds having a free thiol group, oxidizing agents, oxidation catalysts, plant extracts, and combinations thereof, to form a moist tobacco mixture; (ii) heating the moist tobacco mixture at a temperature of at least about 60° C. to form a heat-treated tobacco mixture; and (iii) incorporating the heat-treated tobacco mixture into a tobacco product. Heat-treated tobacco composition prepared according to the method are also provided, such as heat-treated smokeless tobacco composition comprising a tobacco material, water, flavorant, binder, and filler, the heat-treated smokeless tobacco composition having an acrylamide content of less than about 2000 ppb.

The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-HER2 antibody, such as e.g. Trastuzumab (HERCEPTIN™), Pertuzumab or T-DM1, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-HER2 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. The formulations comprise additionally at least one buffering agent, such as e.g. a histidine buffer, a stabilizer or a mixture of two or more stabilizers (e.g. a saccharide, such as e.g. α,α-trehalose dihydrate or sucrose, and optionally methionine as a second stabilizer), a nonionic surfactant and an effective amount of at least one hyaluronidase enzyme. Methods for preparing such formulations and their uses thereof are also provided.

The invention is an enzyme biologic and chemical reaction measure method to mensurate homotype cysteine in a biologic sample. Cysteine can lose its ammonia and be changed into alpha-4-ketone acid, ammonia and sulfureted hydrogen by L-ovi-ammonia acid and Y-dispeling enzyme. Sulfureted hydrogen and fluorescence cpd.DMPD2HCL can create blue product-sub-armour blue whose degree of absorbing light is 670nm, in the situation of Fe3+ and acid. Thus, people can mensurate the chroma of homotype cysteine in a biologic sample by knowing this degree. This method can measure the chroma of homotype cysteine(3-1000 uMs). The invention also involves a reagent box used for implementing the method mentioned above. The box uses liquid double reagents, and needs less quantity of samples(25 microlitre or serum or plasm);In addition, the respond time is short, and the operation is easy. Thus, this method is suitable for a great deal of examinations. The reagent box costs less than other types.

These and other objects of this invention are achieved by providing a novel method and compositions for the clinical treatment of chronic inflammatory diseases. This invention involves use of systemically administered compositions which include primary amine derivatives of benzoic acid as carbonyl trapping agents. These primary therapeutic agents act by chemically binding to and sequestering the aldehyde and/or ketone products of lipid peroxidation. Increased levels of lipid peroxidation have been repeatedly demonstrated as a part of the non-enzymatic "inflammatory cascade" process which underlies the secondary etiology of chronic inflammatory diseases. p-Aminobenzoic acid (or PABA) is an example of the primary therapeutic agent of the present invention. PABA has a small molecular weight, is water soluble, has a primary amine group that reacts with carbonyl-containing metabolites under physiological conditions and is tolerated by the body in relatively high dosages and for extended periods. The carbonyl sequestering agents are used in combination with at least one co-agent so as to produce an additional beneficial physiological effect of an anti-inflammatory nature. Such compositions are administered systemically entirely via the oral route. Co-agents of the present invention include anti-oxidants and free radical trapping compounds (e.g., alpha-tocopherol), compounds having indirect anti-oxidant activity (e.g., selenium), vitamins (e.g., pyridoxine HCl), compounds which facilitate kidney drug elimination (e.g., glycine), metabolites at risk of depletion (e.g., pantothenic acid), sulfhydryl containing chemicals (e.g., methionine), compounds which facilitate glutathione activity (e.g., N-acetylcysteine), and non-absorbable polyamine co-agents (e.g., chitosan).

The problem to be solved is to provide an antibody-containing formulation which is stable and suited for subcutaneous administration, wherein dimerization and deamidation is prevented during long-term storage. The present application is directed to a stable antibody-containing liquid formulation characterized by containing arginine and methionine.

A microorganism strain suitable for fermentative production of L-methionine and preparable from a starting strain, which comprises increased activity of a yjeH gene product or of a gene product of a yjeH homolog, compared to the starting strain.

The invention relates to a layer foodstuff used for enhancing egg laying performance, which has the components in weight portion as follow: 100 to 160 portions of calcium hydrogen phosphate, 250 to 350 portions of mountain flour, 40 to 70 portions of common salt, 20 to 40 portions of saleratus, 12 to 20 portions of choline, 30 to 40 portions of complex trace elements, 8 to 10 portions of complex vitamins, 1 to 3 portions of vitamin C, 25 to 30 portions of methionine, 50 to 100 portions of fish meal, and 250 to 400 portions of zeolite powder. Such additives as nutritive additive are added into the foodstuff in the invention, which has the advantages of apparently strengthening immunity of the layer, maintaining a long egg laying peak period, good quality of an egg shell, high egg laying rate, low layer culling rate, and obviously improving egg laying performance.

Personal care composition comprising at least one hair growth regulating compound selected from the group consisting of glyceryl dilaurate, apigenin, tetrahydrocurcumin, oleanolic acid, azelaic acid, sulforaphane, canavanine, pyridoxal 5-phosphate, phytic acid, tannic acid, grape seed extract, NG-nitro-L-arginine-methyl ester, benzamidine, sodium butyrate, betulinic acid, polyornithine, polyarginine, fisetin, jasmonates, methyl-jasmonate, cis-jasmone, caffeic acid phenethyl ester, delphinidin, ethyl abietate, esculetin, sorbic acid methyl ester, canaline, N-formyl-methionine, N-formyl-alanine, taurine, palmitoyl carnitine, undecanol, undecylenic acid, rutin, fusidic acid, phenyl pyruvic acid, L-isoleucine, phenyl glycine, silibinin, silymarin, L-ascorbic acid-6-palmitate, N-undecylenoyl-L-phenylalanine, and salts, derivatives and mixtures of any of the foregoing; and a dermatologically-acceptable carrier.

The invention relates to a layer foodstuff used for producing health care eggs, consisting of the following components in weight portion: 120 to 160 portions of calcium hydrogen phosphate, 250 to 350 portions of mountain flour, 50 to 60 portions of common salt, 20 to 40 portions of saleratus, 15 to 20 portions of choline, 35 to 40 portions of complex trace elements, 8 to 10 portions of complex vitamins, 10 to 15 portions of lysine, 25 to 30 portions of methionine, 220 to 400 portions of pine needle meal, 1 to 3 portions of bacillus subtilis, 8 to 10 portions of copper sulfate, 2 to 5 portions of phytase, 1 to 5 portions of yeast selenium, 3 to 6 portions of vitamin E, and 250 to 400 portions of Chinese traditional herbal medicine preparation. The invention adds nutritive additives etc. into the foodstuff; therefore the egg laid by the layer contains such beneficial elements as selenium, vitamin E, and is rich in Omega-3 polyunsaturated fatty acid and low in cholesterol.

The invention belongs to the field of feeds, and particularly relates to a six percent-premix for lactating sows and a wheat-type daily ration prepared from the six percent-premix. The premix comprises multivitamins, composite trace elements, DL-methionine, lysine, threonine, L-arginine, valine, composite electrolyte, compound enzyme, 5000 IU of phytase, functional additives, feed attractants, calcium hydrogen phosphate, stone powder, salt, choline, antioxidants and defatted rice bran. On the whole, the daily ration for the lactating sows is capable of protecting the development of mammary glands of the sows, ensuring plentiful milk with high quality in the lactation period of the sows and increasing the survival rate of suckling piglets, and enables the piglets to have higher weaning weight.

Polymerase chain reaction primers and methods directed to detecting the EGFR mutant C→T at the position corresponding to base 2369 of EGFR cDNA. The invention provides a PCR primer that hybridizes under suitable PCR conditions to a polynucleotide sequence 5′ in each respective strand to a mutation of an EGFR gene that encodes a substitution of threonine by methionine at position 790 of the EGFR polypeptide. The invention also provides a PCR primer hybridizes to a sequence that includes a mutant T at the position corresponding to base 2369 of EGFR cDNA but not to a second EGFR polynucleotide containing a wild type C. The invention provides several methods and kits for detecting a mutant epidermal growth factor receptor (EGFR) gene in a sample comprising probing the sample with a means for selectively detecting a nucleotide sequence comprising a mutant T at the position corresponding to base 2369 of EGFR cDNA, and identifying that the base at said position is T. These methods and kits are also useful to predict resistance to the therapeutic effects of gefitinib or erlotinib in a subject suffering from or suspected of having a cancer.

The invention provides a preparation method for feed without antibiotics. Feed without antibiotics is complete pig feed without antibiotics, which is prepared from alkali protease and fermenting mixing feed of wholesome funguses and contains the wholesome funguses, a complex enzyme, complex organic acid and other microbe metabolites. The preparation method comprises the preparation steps: weighingthe raw materials of the fermenting feed: corn flour, bean dregs, fermenting bean dregs, fish meal and whey mist which are uniformly mixed; weighing immune polysaccharide, edible salt, calcium hydrophosphate, calcium carbonate, lysine, methionine, various vitamins and various minerals which are uniformly mixed; preparing wine making yeast, alkyl producing pseudofilament yeast, lactobacillus acidophilus, bacillus subtilis and bacillus licheniformis which are uniformly mixed; uniformly mixing all the raw materials and the funguses; adding water to the feed; bagging; sealing; fermenting until nogas is generated; discharging air; sealing again; sealing an outer packing bag and labeling to obtain a finished product. The feed without antibiotics prepared by the method has the advantages of good mouth feel, high nutritious value, easy assimilation and wide market prospect.

The invention discloses probiotic type premix feed for laying hens, which is prepared from vitamin compound premix feed for the laying hens in laying period, a bacillus and lactobacilli compound preparation, xylan and mannan complex enzyme, phytase, methionine, lycine, choline chloride, common salt, calcium hydrophosphate, stone dust, fish meal, corn gluten meal, sodium bicarbonate, trace element compound premix feed for the laying hens in the laying period, ethoxyquinoline, bentonite, and rice chaff by mixing in proportion. Compared with the common compound feed for the laying hens, the compound feed prepared by the premix feed reduces discharge of harmful substances such as nitrogen and phosphorus in chicken manure by more than 20 percent, reduces the concentration of harmful gases such as ammonia in a hen house by more than 40 percent, improves the feed utilization rate by 5 to 10 percent and the laying rate by 3 to 5 percent, averagely prolongs the laying period by 25 days, and reduces feeding cost by 5 to 8 percent and the death-cull rate of the laying hens.

A composition of bio-active compounds and methods for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells, promoting muscle function and growth, promoting glycogen synthesis, enhancing glucose disposal, stimulating pancreatic beta cells, promoting metabolic recovery, promoting muscle recovery, promoting lean body mass, and promoting fat burning. Preferably, the composition of bio-active compounds includes a combination of 4-hydroxyisoleucine with at least one amino acid selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine, gamma-amino butyrate and tyrosine. In one presently preferred embodiment of the present invention, the combination is derived, isolated, and/or extracted from fenugreek seeds. Methods for using a novel composition of bio-active compounds from fenugreek seed for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells, promoting muscle function and growth, promoting glycogen synthesis, enhancing glucose disposal, stimulating pancreatic beta cells, promoting metabolic recovery, promoting muscle recovery, promoting lean body mass, and promoting fat burning are also disclosed, wherein methods comprise the steps of: (1) providing an effective amount of a composition of bio-active compounds derived, isolated, and/or extracted from fenugreek seeds; and (2) administering the composition to a human or animal.

The invention discloses a corn type mixed feed for a weaned pig and a preparation method thereof. The mixed feed comprises the following raw materials: dried corn, puffed corn, soybean meal, puffed soybean, a wheat germ cake, flour, fish meal, plasma protein powder, whey powder, soya-bean oil, stone flour, calcium hydrogen phosphate, salt, lysine 70%, methionine 99%, threonine 99%, choline chloride 60%, glucose, compound enzyme, a vitamin premix and a trace element premix. The preparation method comprises the following steps: crushing; mixing; and granulation. The invention has the following beneficial effects: nutritional requirements of the weaned pig are met; the mixed feed has good palatability and a high digestive rate and can reduce various discomforts caused by weaning stress, enhance the immunity of the weaned pig, improve food consumption and productivity of the weaned pig, promote rapid and healthy growth of the weaned pig and guarantee the survival rate of the weaned pig.

The invention discloses a compound feed for 0-21-days-old broiler chicken and a preparation method of the compound feed. The compound feed is prepared from various raw materials of corn, flour, soybean meal, 60% of corn protein powder, soybean oil, limestone, calcium hydrophosphate, salt, antimicrobial peptide for the poultry, choline chloride, methionine, threonine, lysine, compound enzyme of corn and soybean meal, premixed vitamin compound, premix compound of trace elements and traditional Chinese medicine addictives. The preparation method for the compound feed comprises the following steps of: weighing all raw materials; putting the raw materials into a pulverizer to be pulverized; putting the pulverized raw materials into a mixer to be uniformly mixed; and granulating the mixed raw materials in a granulator after mixing. The compound feed has the beneficial effects that the compound feed disclosed by the invention is added with the traditional Chinese medicine addictives, so thatthe compound feed can meet the all nature requirements of the green food, diseases can be prevented, the immunity of the organism is enhanced, and the production performance of the broiler chicken can be improved so as to create favorable social value and economic benefits.

The invention provides a pig feed capable of preventing piglets from diarrhea. The pig feed comprises a feed carrier, nano-montmorillonite, acidifier, a probiotic additive, propolis, fish meal, zinc sulfate, chromium nicotinate, methionine, lysine, choline chloride, salt, vitamin A, vitamin E, riboflavin and a traditional Chinese medicine feed additive. The use of the pig feed can decrease diarrhea rate, reduce the occurrence of diseases, promote the fast growth of piglets and increase economic benefits of farmers.

The invention relates to polynucleotides comprising polynucleotide sequences corresponding to the metD gene and parts thereof that encode polypeptide sequences and parts thereof possessing varying degrees of MetD transcription regulator activity, methods for preparation of L-amino acids, and methods of screening and amplifying polynucleotides encoding polypeptide sequences which comprise varying degrees of MetD transcription regulator activity. Further, the invention relates to animal food additives based on fermentation liquor and containing L-methionine, and to the preparation of such additive.

The invention discloses a feed additive and a preparation craft, in particular to a green feed additive for layers and the preparation craft, which is prepared by the mixure of Chinese medicine chemical additive, micro ecology preparation, Vitamin class, trace elements, methionine, chlorination choline, ethoxybenzoylaminoquinoline, rice husk powder and zeolite. The invention has the advantages of nontoxic side effect, no residue, no antibiotic nature, improvement of the laying intensity of layers and the quality of eggs, and enhancement of organism immunity and the anti-stress ability of the organic body.

The invention provides feed for improving growth performances of broiler chickens. The feed comprises a main feed ingredient, bone meal, rapeseed meal, monocalcium phosphate, vitamin E, vitamin K, pantothenic acid, lysine, methionine, threonine, sodium butanoate, enzyme additives, probiotics additives, microelement additives and Chinese medicinal herb additives. The feed can well solve the problem that the feed digestion capability of the broiler chickens is poor, effectively controls pathogenic microorganisms, promotes digestion and immunity of the broiler chickens in the growing process, improves growth performances of the broiler chickens, reduces morbidity and mortality of the broiler chickens and reduces medicine residue rate of antibiotics and chemical synthesis medicines in the broiler chickens.

The present invention discloses a feed for promoting sows aphrodisiac and more farrowing, which belongs to the technical field of pig feed. The feed comprises the components as the weight of 600 to 700 shares of corn, 220 to 280 shares of soybean meal, 20 to 50 shares of corn gluten meal, 20 to 50 shares of fish meal, 10 to 30 shares of soybean oil, 5 to 15 shares of dicalcium phosphate, 10 to 20 shares of rock powder, 3 to 5 shares of salt, 2 to 4 shares of lysine, 0.2 to 0.5 shares of methionine, 0.2 to 0.5 shares of threonine, 2 to 4 shares of minerals vitamin and 5 to 15shares of additives. The sows can definitely have more than four kilograms daily meal after weaning with the feed and feeding about six days, the main function of the present invention is to early estrus, and more litter. Using the feed can make sow early estrus and more litter, and strengthen the needs of nutrition for sows breeding, supplement the iron and zinc trace elements, and enhance the ability of the breeding sows.