87 results about "Head and neck tumors" patented technology

Food products fortified with a therapeutically effective amount of milk mineral are administered for the treatment of high blood pressure, stroke, obesity, kidney stones, colon cancer, breast cancer, head and neck tumors, premenstrual syndrome, postpartum depression, hypertensive disorders of pregnancy, Type-2 diabetes, depression, asthma, inflammatory bowel disease, attention deficit disorder, migraine headaches, kidney disease, hypercholesterolaemia, congestive heart failure, or immune deficiency.

Disclosed are: a method for using a particular microRNA as a biomarker for head-and-neck tumor; a method for the determination of head-and-neck tumor; a kit for the determination of head-and-neck tumor, and the like. The present invention is characterized in that at least one microRNA selected from the group of microRNAs consisting of miR-455-3p, miR-455-5p, miR-130b, miR-130b*, miR-801, miR-196a, miR-21, miR-31, miR-133b, miR-145 and miR-375 is used as a biomarker for head-and-neck tumor.

The invention discloses a method for automatically segmenting head and neck tumors in an MRI image, comprising the steps of training a neural network model based on a U-net, wherein the neural networkmodel comprises a contractive encoder for analyzing an input MRI image and an extension decoder for generating a label map output; combining the appearance feature representation of a shallow encoding layer with the advanced feature representation of a depth decoding layer by using a jump connection in the U-net architecture; and using the neural network model to segment a NPC tumor region imagein the MRI image to be tested. The method can rapidly, stably accurately and automatically segment the NPC tumors in the MRI image.

The invention discloses a compound having the following general formula (I), wherein K is selected from a cycloalkane group shown in the following formula. The invention also discloses an indoleamine-2,3-dioxygenase inhibitor comprising the compound and an application of the compound in preparation of drugs for treating cancer. The compound of the invention can effectively inhibit cell proliferation, has a good therapeutic effect on various diseases such as cancer, has significant therapeutic effects on breast cancer, cervical cancer, colon cancer, lung cancer, stomach cancer, rectal cancer, pancreatic cancer, brain cancer, skin cancer, oral cancer, prostatic cancer, bone cancer, kidney cancer, ovarian cancer, bladder cancer, liver cancer, fallopian tube tumor, ovarian tumor, peritoneal tumor, stage IV melanoma, glioma, glioblastoma, hepatocellular carcinoma, mastoid renal tumor, head and neck tumor, leukemia, lymphoma, myeloma, non-small cell lung cancer, and the like, and has very broad application prospects.

The invention discloses a marker for forecasting an immunotherapy curative effect of head and neck tumors and application. The marker composed of 113 genes can effectively divide patients into an immune type and a nonimmune type, the marker composed of 48 genes is further combined, a patient area can be divided into three subgroups of an immune activation type, an immunodepletion type and the nonimmune type. The immune type is verified through experiments, and especially immune activation type patients can obtain benefits from immunological therapy. Prognosis of the different immune subtypes is further analyzed, immune type patients are found better than nonimmune type patients in the prognosis, after the immune type patients are divided into the immune activation type and the immunodepletion type, the prognosis of the immune activation type patients is the best.

The embodiment of the invention provides a head and neck lymph node and drainage area automatic sketching method based on deep learning. The method utilizes the symmetry of a human body structure to divide a head area into a left part and a right part for training and prediction, thereby indirectly increasing the data volume of model training, and reducing the scale of a deep learning model at thesame time. According to the method, a step-by-step processing optimized sketching strategy is used, the lymphatic drainage area easy to segment is achieved through the deep learning model, then the lymphatic drainage area is optimized and lymph nodes are segmented through the multi-task deep learning model, the relevance between the lymphatic drainage area and the lymph nodes is fully utilized, and the segmentation accuracy of the lymphatic drainage area and the lymph nodes is improved. According to the invention, an AI (artificial intelligence)-assisted contour sketching method is implemented in a radiotherapy plan work flow, so that the sketching consistency of the work efficiency of medical workers can be effectively improved, and the head and neck tumor radiotherapy precision is improved.

It is to provide a novel head-and-neck tumor proliferation inhibitor, head-and-neck tumor metastasis inhibitor and pharmaceutical composition for treating a head-and-neck tumor. The present invention is characterized by using an inhibitory substance of a microRNA whose expression increases in a head-and-neck tumor and / or a promoting substance of a microRNA whose expression decreases in a head-and-neck tumor. Preferred examples of the microRNA whose expression increases in a head-and-neck tumor include miR-455-3p, miR-455-5p, miR-130b, miR-130b*, miR-801, miR-196a, miR-21 and miR-31. Preferred examples of the microRNA whose expression decreases in a head-and-neck tumor include miR-133b, miR-145 and miR-375.

The invention relates to a sustained-release implant for treating a solid tumor, which is characterized in that: the sustained-release implant contains an effective anticancer amount of bortezomib and sustained-release excipients. The solid tumor includes brain tumor, liver cancer, lung cancer, oesophagus cancer, gastric cancer, breast cancer, pancreatic cancer, thyroid cancer, nasopharyngeal cancer, ovarian cancer, endometrial cancer, cervical cancer, renal cancer, prostate cancer, bladder cancer, colon cancer, rectal cancer, skin cancer, head and neck cancer and primary or secondary cancer, caruncle or carcinosarcoma rooted at a peripheral nervous system, mucosa, glands, blood vessels, bone tissues and lymph nodes. The sustained-release excipients are mainly a biological polymer which is dissoluble and can be degraded and absorbed, in the degradation and absorption process of which carmustine is sustainedly released to part of the tumor, thus the entire toxicity of the carmustine is significantly reduced while an effective medicine consistency is maintained on part of the tumor. That the sustained-release implant is implanted inside part of the tumor can not only reduce the entire toxicity of the carmustine but also enhance the medicine consistency on part of the tumor, thereby increasing the curing effect of non-operative therapeutics such as chemotherapeutic drugs and radiotherapy.

The invention relates to a serum surface enhanced Raman spectrum based parotid tumor diagnosis technology, which is a novel technology directed at parotid tumor diagnosis by head and neck tumor surgery and oral and maxillofacial surgery. The technology mainly solves the problem that a conventional biopsy technique cannot be employed for definite diagnosis of parotid tumor patients before operation, replaces the parotid tumor local puncture biopsy technology, avoids complications caused thereby, simultaneously alleviates the work intensity of pathologists, and provides the basis for surgeons to adopt different operative treatment modes according to the benign / malignant nature of tumors. According to the technology, nanoscale gold sol particles are added into parotid tumor patient serum to enhance the intensity of a Raman spectrum so as to obtain a characteristic surface enhanced Raman spectrum of the tumor patient serum. Through analysis of a support vector machine on characteristic spectral data, a differential diagnosis model can be established for identifying different parotid tumors and providing the objective basis for preoperative diagnosis, thus establishing a quick and noninvasive new diagnosis technique.

The invention discloses a novel application of nitrate on an aspect of preventing radiation-induced salivary gland damage, and belongs to the fields of medicine and health. Upon clinical researches and animal experiments, it finally verifies that the nitrate, through oral administration, can be used for effectively preventing the radiation-induced salivary gland damage and for improving the symptom of xerostomia in patients with head and neck tumors due to radiotherapy. The nitrate disclosed by the invention can be used for preparing medicine which is effective on preventing the radiation-induced salivary gland damage; therefore, a novel way is provided for the clinical treatment of radiation-induced xerostomia.

The invention discloses a cancer therapeutic medicine capable of killing medicine-resistant tumor cells and tumor stem cells in chemicotherapy and an application thereof. The medicine is characterized by comprising the following components: the liquid medicine in every 100 milliliters contains 2-10ml of absolute ethyl alcohol, 40-50mg of cis-platinum complexes and 90-98ml of sterile water. The medicine is mainly used for local injection of tumors or intravesical therapy of chest, abdomen, pericardial cavity malignant effusion or aerosol inhalation therapy of lung tumors, and is suitable for the therapy of various solid tumors such as lung cancer, liver cancer, pancreatic cancer, ovarian cancer, cervical cancer, mammary cancer, retroperitoneal tumor or retroperitoneal lymph node metastasis, cardia cancer, gastrointestinal malignant cancer, soft tissue sarcoma, glioma and head and neck neoplasm and the medicine-resistant or medicine-sensitive tumor therapy with chest, abdomen, pericardial cavity malignant effusion.

The invention discloses compounds represented by a general formula (I) shown in the description, wherein in the formula (I), A and B are respectively a six-membered cyclic compound containing D1, D2,D3 and D4 and a six-membered cyclic compound containing D5, D6, D7 and D8. The invention also disclose an indoleamine-2,3-dioxygenase and / or tryptophan-2,3-dioxygenase inhibitor containing the above compounds and the application of the compounds in preparation of medicaments for treating cancers. The compounds provided by the invention can effectively inhibit cell proliferation, and have good therapeutic effects on various diseases such as the cancers, significant therapeutic effects on breast cancer, cervical cancer, colon cancer, lung cancer, stomach cancer, rectal cancer, pancreatic cancer,brain cancer, skin cancer, oral cancer, prostate cancer, bone cancer, kidney cancer, ovarian cancer, bladder cancer, liver cancer, fallopian tube tumors, ovarian tumors, peritoneal tumors, stage IV melanoma, glioma, neuroblastoma, hepatocellular carcinoma, mastoid renal tumors, head and neck tumors, leukemia, lymphoma, myeloma and non-small cell lung cancers, and very broad application prospects.

This invention relates to the use of 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)urea (hereinafter also referred to as HECNU) for treatment of pancreatic carcinomas, soft tissue sarcomas, testicular tumors, lymphomas, thymomas, Wilms' tumors, renal carcinomas, melanomas, lung tumors, intracerebral metastases, tumors in the head and neck area and mammary carcinomas.

The radiotherapy positioning integrated bracket mainly comprises three parts: a main supporting plate, a buttock supporting plate, and a foot supporting plate, which can be prepared by high-density carbon fiber boards and have good passability to radiotherapy rays. The main supporting plate, the buttock supporting plate and the foot supporting plate are subjected to butt joint by a heterotype structure, and the access is free and convenient. The main supporting plate can be used independently. The main supporting plat can be used alone, and can be combined with a head mask and a head and neckmask to fix the radiation therapy of the head and neck tumor patients. The main supporting plat is used by adding an accessory arm rest and a hand rest to conveniently complete the fixation of the radiation therapy of the chest and mammary gland tumor patients. The buttock supporting plate is subjected to butt joint with the main supporting plate by the heterotype structure. After extending the length of the main supporting plate, the chest, abdomen and buttocks of the patients are fixed by conveniently using buckle peritoneum to perform the radiotherapy of the abdominal patient. The foot supporting plate is subjected to butt joint with the buttock supporting plate by the heterotype structure. For the treatment process, the fixation of the foot can prevent the foot from shaking back and forth to affect the treatment.

The invention relates to a proton and light ion synchrotron, a treatment system comprising the same and application, the proton and light ion synchrotron comprises a plurality of beam deflection units and a plurality of linear segments, and the plurality of beam deflection units are arranged on a ring at intervals, are sequentially connected end to end through vacuum tubes, and are used for deflecting beams; and the plurality of straight line segments are sequentially formed among the plurality of beam deflection units and are used for focusing, injecting, accelerating and entering and exiting the beam. The accelerator system can accelerate protons and various light ions such as 3He and 4He, the protons can be used for whole body treatment, light ion beams can also be used for superficial layer tumor treatment such as melanoma, head and neck tumors of five sense organs and prostate tumors, various ions complement each other, and the range of tumor indications of the proton accelerator is widened.

The invention relates to a head and neck tumor distal metastasis prediction method based on machine learning, and the method comprises the steps: building an improved convolutional neural network, training a built network model through the head and neck CT image data of a head and neck tumor patient with distal metastasis, and predicting the distal metastasis of the head and neck tumor after the training; and inputting a head and neck CT image of a head and neck tumor patient, which is shot in real time, into the network model, and outputting a result as far-end metastasis prediction of the head and neck CT image of the head and neck tumor patient. A radiomics method is adopted to replace a biopsy method to predict far-end metastasis of head and neck cancers, the pain that a head and neck patient suffers from multiple times of biopsy is avoided, a deep learning method is adopted to supplement a feature extraction algorithm of original radiomics, and the problem that the number of head and neck medical images is small is solved.

The invention discloses a head and neck soft tissue defect reconstruction operation template design method based on curved surface feature classification processing and expansion. The method comprisesthe following steps: 1, carrying out expandability analysis and curved surface classification on head and neck soft tissue surface curvature distribution based on a standard model; 2, designing and preparing a soft tissue analysis and defect area soft tissue excision template and a flap acquisition template of a specific case lesion area. According to the head and neck soft tissue defect reconstruction operation template design method based on curved surface feature classification processing and expansion and an operation template, a supply area soft tissue three-dimensional model and a defect part three-dimensional model can be constructed based on CT data of a patient before an operation; the shape and the size of the transplanted flap are accurately designed according to the actual shape requirement of a defect part, a doctor is guided to accurately complete flap obtaining, shaping, transplanting and other surgical operations by designing and manufacturing a surgical template, andthe problem of accurate reconstruction of soft tissue defects after head and neck tumor excision can be effectively solved.

The invention belongs to the field of medical rehabilitation nursing based on oral and maxillofacial head and neck tumors, and particularly discloses an artificial intelligence based oral and maxillofacial head and neck tumor rehabilitation nursing system. The system comprises a patient smart terminal, an AI processing system and a hospital nursing smart terminal which are in communication connection. The patient smart terminal is integrated with a touch input display screen module, an acquisition module, an uploading module and an alarm communication module, the touch input display screen module is used for inputting and storing patient basic information, case information and evaluation questionnaire information, and the acquisition module is used for acquiring image, video and audio information in a patient recovery process. The uploading module is connected with the touch input display screen module and the acquisition module and uploads the stored patient basic information, case information, evaluation questionnaire information and image, video and audio information to the AI processing system. The training standard degree of the patient can be automatically recognized, and further rehabilitation decision making is assisted.

The invention relates to in vitro cell culture methods for expanding epithelial cells from head and neck tissue, including head and neck tumour tissue, to obtain organoids. The invention relates to culture media suitable for use with said methods, organoids obtainable or obtained by said methods and uses of said culture methods, media and organoids in drug discovery and validation, toxicity assays, diagnostics and therapy.

The invention belongs to the technical field of medicines, and particularly relates to a photothermal therapy and chemical therapy combined targeted medicine delivery system which comprises a targeted functional molecule, a chemotherapy medicine and a nano-carrier. The targeted functional molecule is an active targeted antibody. The chemotherapy medicine is doxorubicin. The nano-carrier is a pegylated nanometer golden ball with a photothermal effect. The chemotherapy medicine is connected to the pegylated nanometer golden ball through a chemical bound and the antibody. The targeted medicine delivery system has the advantages that the medicine-carrying system has the targeting property, low toxicity and good cell intake, the high-efficiency anti-tumor property can be realized through the combination of photothermal therapy and chemical therapy, the gathering on the oral cavity, head and neck tumor tissue is increased, the damage of chemotherapy medicines to other normal tissue is reduced, and the tumor treatment effect is remarkably improved.

The invention provides a T lymphocyte of a chimeric chondroitin sulfate proteoglycan 4 receptor. The T lymphocyte comprises an extracellular domain structure, a human CD28 transmembrane sequence and an intracellular domain structure, wherein the extracellular domain structure is formed by sequentially connecting a signal peptide sequence, an optimized CSPG4 single-chain antibody sequence and a sequence with a human immunoglobulin G2 mutation sequence as a hinge region in series; a genetic sequence of the optimized CSPG4 single-chain antibody is as shown in any one of SEQ ID NO.33-42; a geneticsequence of the hinge region is as shown in SEQ ID NO.31; and the intracellular domain structure is formed by connecting a human CD28 or 41BB intracellular domain costimulatory domain sequence and ahuman CD3[zeta] intracellular domain sequence in series. The invention also provides a preparation method of the T lymphocyte of the chimeric chondroitin sulfate proteoglycan 4 receptor. Meanwhile, the invention provides an application of the T lymphocyte in preparation of drugs for treatment of head and neck tumors. The optimized CSPG4.CAR-T cell can be used for effectively killing the CSPG4 positive tumor cells in vitro and vivo.

The invention relates to a medicinal composition for treating xerostomia after radiotherapy of head and neck tumors and an application thereof. The medicinal composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 28-45 parts of sophora japonica flower, 13-21 parts of flos Lonicerae, 24-37 parts of semen pruni, 8-14 parts of lotus leaf, 13-21 parts of sterculia lychnophora, 28-45 parts of bamboo leaf and 12-20 parts of citrus reticulata. The medicinal composition disclosed by the invention can not only keep oral cavity wet and clean and increase appetite, but also can reduce discomfortableness caused by radiotherapy of head and neck tumors.

The invention discloses a head and neck tumor clinical decision-making, teaching and scientific research auxiliary support system and method. According to the system and method, a medical and pharmaceutical data storage unit, a diagnosis and treatment parameter storage unit, an information input unit, a comparison processor unit, a diagnosis and treatment result output unit and an early warning and operation recording unit are adopted, feasible clinical diagnosis and treatment scheme suggestions and corresponding clinical research and real world research evidence support can be provided for related medical workersaccording to patient disease specificity information parameter values,the whole disease cycle of screening diagnosis, treatment, monitoring follow-up visit, out-of-hospital management and the like is covered, and doctors are assisted to quickly improve the clinical diagnosis and treatment level, learn and update diagnosis and treatment knowledge, master the research status and development direction of clinical research and real-world diagnosis and treatment, improve the scientific research level and solve the contradiction that time and energy of medical workers are difficult to follow the clinical research progress.

The invention belongs to the technical field of head and neck neoplasm radiotherapy, and particularly relates to a head and neck neoplasm radiotherapeutic protection and functional training device. The device comprises a lower supporting frame, an upper supporting frame and a supporting plate, wherein the lower supporting frame comprises a front border, a rear border, left and right telescopic rods which are connected with two ends of the front and rear borders; the upper supporting frame comprises a left border, a right border and a cross beam, and the front ends of the left and right borders are respectively connected with the cross beam in a hinged manner, and the rear ends of the left and right borders are respectively connected with the rear border in a hinged manner; a tongue depressor is arranged on the rear border, an upper bracket is arranged at the upper part of the cross beam; slots are formed in the cross beam and the front border, pins matched with the slots are arranged on the supporting plate; a through hole is formed in the supporting plate; marking lines are formed in the bottom edge and two sides of the supporting plate. The head and neck neoplasm radiotherapeutic protection and functional training device can be used for stably and effectively reducing radiation dosage harmful to organs, so that injury on oral mucosa and taste in radiotherapeutic treatment process can be reduced, the compliance and living quality of patients receiving radiotherapeutic treatment can be improved.

The invention discloses a head and neck tumor postoperative rehabilitation nursing device, and belongs to the field of medical nursing. The device comprises a bottom plate, an arch plate is mounted on the upper side of the right end of the bottom plate, a headrest is hinged to the upper side of the front end of the bottom plate, the front and rear sides of the headrest are jointly hinged to the bottom plate to be provided with a pressure supply telescopic pipe, the pressure supply telescopic pipe comprises a sleeve and a sliding rod which are installed in a sliding mode, the bottom end of the sliding rod extends into the sleeve and is fixedly provided with a limiting ring, and a first spring is installed in the sleeve. Rehabilitation training during head turning, head raising and nodding can be provided for a patient, the training modes are richer and more diversified, the dependence on medical staff in the training process is low, the training autonomy of the patient is improved, the training effect is improved, the stability of the device is high, the device has good applicability to patients with different body lengths, the bed head or the bed can be moved when not used, storage is convenient, occupied space is reduced, and re-training use is facilitated.

The invention relates to a traditional Chinese medicine for preventing and treating adverse reactions after radiation on head and neck tumors. The traditional Chinese medicine is prepared from the following traditional Chinese medicine materials in parts by weight: 5-15 parts of radix ophiopogonis, 5-15 parts of asparagus cochinchinensis, 5-15 parts of adenophora stricta,5-15 parts of schisandra chinensis, 5-15 parts of codonopsis pilosula, 5-15 parts of honeysuckle, 5-15 parts of rhizoma polygonati, 5-15 parts of matrimony vine, 3-9 parts of chrysanthemum and 10-20 parts of Chinese yam. The traditional Chinese medicine is non-toxic, harmless, and scientific in formula; all the medicine materials contained in the traditional Chinese medicine are compatible and jointly play the effects of protecting a parotid gland and a salivary gland, regulating immune and relieving oral mucosa reactions; and the traditional Chinese medicine is convenient to take and remarkable in treatment effect.

The invention discloses a post-radiotherapy mouth opening exercising device for a head and neck tumor patient. The device comprises a connecting mechanism, a mounting strip, a button battery, a driving mechanism, a connecting strip, a control mechanism, an anti-rotating pin and a pressing block. According to the post-radiotherapy mouth opening exercising device for a head and neck tumor patient, apatient does not need to actively open the mouth, and the mouth of the patient can subjected to reciprocating mouth opening training treatment in a passive state for, so that the phenomena that reactive exudation, hardening, maxillofacial soft tissue fibrosis, adhesion, contracture and limited joint movement are generated on the treatment part of the patient. Therefore, by means of the device, the exercise effect of the mouth of the patient is improved, and the exercise efficiency of the mouth of the patient is also improved.

The invention discloses a method for evaluating skeletal muscle indexes of a head and neck tumor patient through CBCT (cone beam computed tomography), which comprises the following steps: measuring the skeletal muscle indexes of the head and neck tumor patient receiving radiotherapy by using an image-guided radiotherapy technology CBCT conventionally used every week before radiotherapy and during radiotherapy of the head and neck tumor patient; compared with an existing skeletal muscle assessment tool, the skeletal muscle assessment method has the advantages of accuracy and small radiation, and the detection cost of a patient is saved; according to the method, skeletal muscle changes of the head and neck tumor patient during radiotherapy can be dynamically evaluated, the skeletal muscle loss percentage is calculated, and a basis is provided for timely clinical nutrition intervention.