84 results about "Head and neck tumors" patented technology

Food products fortified with a therapeutically effective amount of milk mineral are administered for the treatment of high blood pressure, stroke, obesity, kidney stones, colon cancer, breast cancer, head and neck tumors, premenstrual syndrome, postpartum depression, hypertensive disorders of pregnancy, Type-2 diabetes, depression, asthma, inflammatory bowel disease, attention deficit disorder, migraine headaches, kidney disease, hypercholesterolaemia, congestive heart failure, or immune deficiency.

Disclosed are: a method for using a particular microRNA as a biomarker for head-and-neck tumor; a method for the determination of head-and-neck tumor; a kit for the determination of head-and-neck tumor, and the like. The present invention is characterized in that at least one microRNA selected from the group of microRNAs consisting of miR-455-3p, miR-455-5p, miR-130b, miR-130b*, miR-801, miR-196a, miR-21, miR-31, miR-133b, miR-145 and miR-375 is used as a biomarker for head-and-neck tumor.

The invention discloses a method for automatically segmenting head and neck tumors in an MRI image, comprising the steps of training a neural network model based on a U-net, wherein the neural networkmodel comprises a contractive encoder for analyzing an input MRI image and an extension decoder for generating a label map output; combining the appearance feature representation of a shallow encoding layer with the advanced feature representation of a depth decoding layer by using a jump connection in the U-net architecture; and using the neural network model to segment a NPC tumor region imagein the MRI image to be tested. The method can rapidly, stably accurately and automatically segment the NPC tumors in the MRI image.

The invention discloses a compound having the following general formula (I), wherein K is selected from a cycloalkane group shown in the following formula. The invention also discloses an indoleamine-2,3-dioxygenase inhibitor comprising the compound and an application of the compound in preparation of drugs for treating cancer. The compound of the invention can effectively inhibit cell proliferation, has a good therapeutic effect on various diseases such as cancer, has significant therapeutic effects on breast cancer, cervical cancer, colon cancer, lung cancer, stomach cancer, rectal cancer, pancreatic cancer, brain cancer, skin cancer, oral cancer, prostatic cancer, bone cancer, kidney cancer, ovarian cancer, bladder cancer, liver cancer, fallopian tube tumor, ovarian tumor, peritoneal tumor, stage IV melanoma, glioma, glioblastoma, hepatocellular carcinoma, mastoid renal tumor, head and neck tumor, leukemia, lymphoma, myeloma, non-small cell lung cancer, and the like, and has very broad application prospects.

The embodiment of the invention discloses a multi-database interactive system for head and neck tumor gene mutation and drug interpretation. The multi-database interactive system for head and neck tumor gene mutation and drug interpretation comprises: a head and neck tumor gene mutation information database, a head and neck cancer drug treatment database, and a head and neck tumor literature information database; the databases are used to store corresponding data; wherein the head and neck cancer drug treatment database includes a head and neck tumor gene mutation and drug treatment approval information database, a head and neck tumor gene mutation and drug treatment expert consensus information database, and a head and neck tumor gene mutation and drug treatment clinical trial informationdatabase. Through the establishment of multi-database interactive system, it is possible to store head and neck tumor gene mutations and drug-related data, and the data volume of the interactive system is perfect and easy to use.

The embodiment of the invention provides a head and neck lymph node and drainage area automatic sketching method based on deep learning. The method utilizes the symmetry of a human body structure to divide a head area into a left part and a right part for training and prediction, thereby indirectly increasing the data volume of model training, and reducing the scale of a deep learning model at thesame time. According to the method, a step-by-step processing optimized sketching strategy is used, the lymphatic drainage area easy to segment is achieved through the deep learning model, then the lymphatic drainage area is optimized and lymph nodes are segmented through the multi-task deep learning model, the relevance between the lymphatic drainage area and the lymph nodes is fully utilized, and the segmentation accuracy of the lymphatic drainage area and the lymph nodes is improved. According to the invention, an AI (artificial intelligence)-assisted contour sketching method is implemented in a radiotherapy plan work flow, so that the sketching consistency of the work efficiency of medical workers can be effectively improved, and the head and neck tumor radiotherapy precision is improved.

It is to provide a novel head-and-neck tumor proliferation inhibitor, head-and-neck tumor metastasis inhibitor and pharmaceutical composition for treating a head-and-neck tumor. The present invention is characterized by using an inhibitory substance of a microRNA whose expression increases in a head-and-neck tumor and/or a promoting substance of a microRNA whose expression decreases in a head-and-neck tumor. Preferred examples of the microRNA whose expression increases in a head-and-neck tumor include miR-455-3p, miR-455-5p, miR-130b, miR-130b*, miR-801, miR-196a, miR-21 and miR-31. Preferred examples of the microRNA whose expression decreases in a head-and-neck tumor include miR-133b, miR-145 and miR-375.

The invention relates to a sustained-release implant for treating a solid tumor, which is characterized in that: the sustained-release implant contains an effective anticancer amount of bortezomib and sustained-release excipients. The solid tumor includes brain tumor, liver cancer, lung cancer, oesophagus cancer, gastric cancer, breast cancer, pancreatic cancer, thyroid cancer, nasopharyngeal cancer, ovarian cancer, endometrial cancer, cervical cancer, renal cancer, prostate cancer, bladder cancer, colon cancer, rectal cancer, skin cancer, head and neck cancer and primary or secondary cancer, caruncle or carcinosarcoma rooted at a peripheral nervous system, mucosa, glands, blood vessels, bone tissues and lymph nodes. The sustained-release excipients are mainly a biological polymer which is dissoluble and can be degraded and absorbed, in the degradation and absorption process of which carmustine is sustainedly released to part of the tumor, thus the entire toxicity of the carmustine is significantly reduced while an effective medicine consistency is maintained on part of the tumor. That the sustained-release implant is implanted inside part of the tumor can not only reduce the entire toxicity of the carmustine but also enhance the medicine consistency on part of the tumor, thereby increasing the curing effect of non-operative therapeutics such as chemotherapeutic drugs and radiotherapy.

The invention discloses compounds represented by a general formula (I) shown in the description, wherein in the formula (I), A and B are respectively a six-membered cyclic compound containing D1, D2,D3 and D4 and a six-membered cyclic compound containing D5, D6, D7 and D8. The invention also disclose an indoleamine-2,3-dioxygenase and/or tryptophan-2,3-dioxygenase inhibitor containing the above compounds and the application of the compounds in preparation of medicaments for treating cancers. The compounds provided by the invention can effectively inhibit cell proliferation, and have good therapeutic effects on various diseases such as the cancers, significant therapeutic effects on breast cancer, cervical cancer, colon cancer, lung cancer, stomach cancer, rectal cancer, pancreatic cancer,brain cancer, skin cancer, oral cancer, prostate cancer, bone cancer, kidney cancer, ovarian cancer, bladder cancer, liver cancer, fallopian tube tumors, ovarian tumors, peritoneal tumors, stage IV melanoma, glioma, neuroblastoma, hepatocellular carcinoma, mastoid renal tumors, head and neck tumors, leukemia, lymphoma, myeloma and non-small cell lung cancers, and very broad application prospects.

This invention relates to the use of 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)urea (hereinafter also referred to as HECNU) for treatment of pancreatic carcinomas, soft tissue sarcomas, testicular tumors, lymphomas, thymomas, Wilms' tumors, renal carcinomas, melanomas, lung tumors, intracerebral metastases, tumors in the head and neck area and mammary carcinomas.

The invention belongs to the field of medical rehabilitation nursing based on oral and maxillofacial head and neck tumors, and particularly discloses an artificial intelligence based oral and maxillofacial head and neck tumor rehabilitation nursing system. The system comprises a patient smart terminal, an AI processing system and a hospital nursing smart terminal which are in communication connection. The patient smart terminal is integrated with a touch input display screen module, an acquisition module, an uploading module and an alarm communication module, the touch input display screen module is used for inputting and storing patient basic information, case information and evaluation questionnaire information, and the acquisition module is used for acquiring image, video and audio information in a patient recovery process. The uploading module is connected with the touch input display screen module and the acquisition module and uploads the stored patient basic information, case information, evaluation questionnaire information and image, video and audio information to the AI processing system. The training standard degree of the patient can be automatically recognized, and further rehabilitation decision making is assisted.

The invention relates to in vitro cell culture methods for expanding epithelial cells from head and neck tissue, including head and neck tumour tissue, to obtain organoids. The invention relates to culture media suitable for use with said methods, organoids obtainable or obtained by said methods and uses of said culture methods, media and organoids in drug discovery and validation, toxicity assays, diagnostics and therapy.

The invention belongs to the technical field of medicines, and particularly relates to a photothermal therapy and chemical therapy combined targeted medicine delivery system which comprises a targeted functional molecule, a chemotherapy medicine and a nano-carrier. The targeted functional molecule is an active targeted antibody. The chemotherapy medicine is doxorubicin. The nano-carrier is a pegylated nanometer golden ball with a photothermal effect. The chemotherapy medicine is connected to the pegylated nanometer golden ball through a chemical bound and the antibody. The targeted medicine delivery system has the advantages that the medicine-carrying system has the targeting property, low toxicity and good cell intake, the high-efficiency anti-tumor property can be realized through the combination of photothermal therapy and chemical therapy, the gathering on the oral cavity, head and neck tumor tissue is increased, the damage of chemotherapy medicines to other normal tissue is reduced, and the tumor treatment effect is remarkably improved.

The invention provides a T lymphocyte of a chimeric chondroitin sulfate proteoglycan 4 receptor. The T lymphocyte comprises an extracellular domain structure, a human CD28 transmembrane sequence and an intracellular domain structure, wherein the extracellular domain structure is formed by sequentially connecting a signal peptide sequence, an optimized CSPG4 single-chain antibody sequence and a sequence with a human immunoglobulin G2 mutation sequence as a hinge region in series; a genetic sequence of the optimized CSPG4 single-chain antibody is as shown in any one of SEQ ID NO.33-42; a geneticsequence of the hinge region is as shown in SEQ ID NO.31; and the intracellular domain structure is formed by connecting a human CD28 or 41BB intracellular domain costimulatory domain sequence and ahuman CD3[zeta] intracellular domain sequence in series. The invention also provides a preparation method of the T lymphocyte of the chimeric chondroitin sulfate proteoglycan 4 receptor. Meanwhile, the invention provides an application of the T lymphocyte in preparation of drugs for treatment of head and neck tumors. The optimized CSPG4.CAR-T cell can be used for effectively killing the CSPG4 positive tumor cells in vitro and vivo.

The invention relates to a medicinal composition for treating xerostomia after radiotherapy of head and neck tumors and an application thereof. The medicinal composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 28-45 parts of sophora japonica flower, 13-21 parts of flos Lonicerae, 24-37 parts of semen pruni, 8-14 parts of lotus leaf, 13-21 parts of sterculia lychnophora, 28-45 parts of bamboo leaf and 12-20 parts of citrus reticulata. The medicinal composition disclosed by the invention can not only keep oral cavity wet and clean and increase appetite, but also can reduce discomfortableness caused by radiotherapy of head and neck tumors.

The invention discloses a head and neck tumor postoperative rehabilitation nursing device, and belongs to the field of medical nursing. The device comprises a bottom plate, an arch plate is mounted on the upper side of the right end of the bottom plate, a headrest is hinged to the upper side of the front end of the bottom plate, the front and rear sides of the headrest are jointly hinged to the bottom plate to be provided with a pressure supply telescopic pipe, the pressure supply telescopic pipe comprises a sleeve and a sliding rod which are installed in a sliding mode, the bottom end of the sliding rod extends into the sleeve and is fixedly provided with a limiting ring, and a first spring is installed in the sleeve. Rehabilitation training during head turning, head raising and nodding can be provided for a patient, the training modes are richer and more diversified, the dependence on medical staff in the training process is low, the training autonomy of the patient is improved, the training effect is improved, the stability of the device is high, the device has good applicability to patients with different body lengths, the bed head or the bed can be moved when not used, storage is convenient, occupied space is reduced, and re-training use is facilitated.

The invention relates to a traditional Chinese medicine for preventing and treating adverse reactions after radiation on head and neck tumors. The traditional Chinese medicine is prepared from the following traditional Chinese medicine materials in parts by weight: 5-15 parts of radix ophiopogonis, 5-15 parts of asparagus cochinchinensis, 5-15 parts of adenophora stricta,5-15 parts of schisandra chinensis, 5-15 parts of codonopsis pilosula, 5-15 parts of honeysuckle, 5-15 parts of rhizoma polygonati, 5-15 parts of matrimony vine, 3-9 parts of chrysanthemum and 10-20 parts of Chinese yam. The traditional Chinese medicine is non-toxic, harmless, and scientific in formula; all the medicine materials contained in the traditional Chinese medicine are compatible and jointly play the effects of protecting a parotid gland and a salivary gland, regulating immune and relieving oral mucosa reactions; and the traditional Chinese medicine is convenient to take and remarkable in treatment effect.

The invention discloses a method for evaluating skeletal muscle indexes of a head and neck tumor patient through CBCT (cone beam computed tomography), which comprises the following steps: measuring the skeletal muscle indexes of the head and neck tumor patient receiving radiotherapy by using an image-guided radiotherapy technology CBCT conventionally used every week before radiotherapy and during radiotherapy of the head and neck tumor patient; compared with an existing skeletal muscle assessment tool, the skeletal muscle assessment method has the advantages of accuracy and small radiation, and the detection cost of a patient is saved; according to the method, skeletal muscle changes of the head and neck tumor patient during radiotherapy can be dynamically evaluated, the skeletal muscle loss percentage is calculated, and a basis is provided for timely clinical nutrition intervention.

The invention discloses an intelligent rehabilitation follow-up visit system for oral and maxillofacial head and neck tumors. The intelligent rehabilitation follow-up visit system comprises an artificial intelligence control module, a patient intelligent screen, a chief hospital intelligent screen and a plurality of alliance hospital intelligent screens; a standard recognition model is carried in the artificial intelligence control module, and a patient intelligent rehabilitation learning video to be pushed to the patient intelligent screen is recorded; the patient intelligent screen receives a patient intelligent rehabilitation learning video pushed by the artificial intelligence control module, displays the video to the patient for learning training, and collects images and audio information of the patient for learning training and feeds back the images and audio information to the artificial intelligence control module; the artificial intelligence control module compares, identifies and analyzes the collected images and audio information with a pre-trained standard identification model, judges whether the learning training result of the patient meets the training standard or not, and feeds back the judgment result to the chief hospital intelligent screen to inform and remind nursing personnel to follow up and guide; and effective rehabilitation guidance is realized for the postoperative patient with oral and maxillofacial head and neck tumors.