4 results about "Peritoneum" patented technology

The invention discloses application of a hydrogel microneedle capable of being implanted into an abdominal cavity in colorectal cancer abdominal wall infiltration focus, and relates to the field of medicine. The traditional Chinese medicine composition is applied to clinical treatment of rectal cancer abdominal wall infiltration lesions, and a mouse subcutaneous tumor model and the abdominal wall infiltration lesions are verified, and the specific application method comprises the following steps that 1, after a mouse is subjected to general anesthesia, the abdomen of the mouse is opened, and the position of the abdominal wall infiltration lesions is detected and determined; step 2, clamping the sterilized micro-needle sheet by using noninvasive forceps and feeding the sterilized micro-needle sheet into an abdominal cavity; 3, attaching the microneedle substrate to the surface of a focus under direct view, and pressing to enable the needle body to penetrate through the peritoneum; and 4, flushing with normal saline to confirm that the microneedle is fixed, withdrawing the instrument, and suturing the incision. The microneedle physically penetrates through the surface layer of the peritoneum, the medicine is directly delivered to the deep layer of an infiltrating focus, the problem of low efficiency caused by the peritoneum barrier in the traditional therapy is solved, and the GelMA / hyaluronic acid hydrogel is gradually swelled and degraded in body fluid, so that collagenase, a macrophage scavenger and an anti-tumor medicine are continuously released, and the local effective concentration can be maintained for more than two weeks.

This product prevents inguinal hernias, which occur when the peritoneum is torn and the intestines protrude downward, by lifting and holding the penis and scrotum, preventing the intestines from dropping, and the internal sponge wire makes it possible to hold down multiple affected areas.

The invention discloses a bacterial infection and LPS induced broiler chicken liver injury model and a construction method and application thereof, and the construction method comprises the following steps: administering 10-day-old broiler chicken with Escherichia coli E.coli O78 with a preset concentration in an intragastric administration manner; after broiler chickens are subjected to intragastric administration of escherichia coli for 18 hours, an LPS solution is injected into the intraperitoneal cavity of the broiler chickens, after the LPS solution is injected for 24 hours, the broiler chicken liver injury model is obtained, when the broiler chickens are 11 days old, the broiler chickens subjected to intragastric administration of escherichia coli are subjected to intraperitoneal injection of the LPS solution, and after the LPS solution is injected for 24 hours, the broiler chicken liver injury model is obtained. The broiler chicken liver injury model is constructed by intragastric administration of avian pathogenic escherichia coli (E.coli O78) and intraperitoneal injection of LPS (2 mg / kg), the pathology of the model is highly consistent with that of clinical broiler chicken bacterial liver injury, the liver has clinical typical lesions macroscopically, liver cells are degenerative and necrotic microscopically, and a molecular pathway activation mode is consistent with that of clinical application; the model constructed by the invention realizes specific liver injury, only the liver has specific injury, multiple organ lesions such as heart, peritoneum and the like do not exist, and the model availability is high.

This model helps in understanding the gross anatomy (shape, relative size, and three-dimensional positional relationship) of the intestines and mesentery. It is useful for medical students and young healthcare professionals to acquire basic knowledge for understanding the pathophysiology of diseases and injuries of abdominal organs, as well as for examination and treatment. [Solution] The model 50 has an intestinal tract 2 covered and embedded by the peritoneum 1, an intestinal tract 2 provided in the posterior abdominal wall 4 in a form where much of the outer circumference is covered by the peritoneum 1, and an intestinal tract 2 provided in the posterior abdominal wall 4 via the mesentery 5, wherein each of the intestinal tracts 2 is made of a flexible and smooth pliable material and attached to a substrate 23 which is the posterior abdominal wall 4, and each of the intestinal tracts 2 and the mesentery 5 are configured to be the same as or approximately the same length and thickness as those in living organisms, thereby solving the above problem.