86 results about "Tissue temperature" patented technology

Sonodynamic therapy systems and methods use short, high-pressure ultrasound pulses that produce small (and therefore clinically safe) increases (up to 1-2° C.) in tissue temperature but nonetheless activate sonodynamic agents, allowing isolated single-cav-itation events to produce therapeutically beneficial effects (e.g., cytotoxicity) on diseased tissue. An escalating sonication strategy may be employed whereby the focal pressure is gradually increased until maximum clinically tolerable parameters such as the degree of heating of intervening tissue (e.g., the skull when treating brain cancer) or undesired induced cavitation effects are reached.

The invention discloses a temperature-controllable preparation method for tissue temperature dissociation into single cells and application, the temperature-controllable preparation method for tissue temperature dissociation into single cells comprises the following steps: S1, providing a tissue sample, and pre-treating the tissue sample to obtain a sample block; s2, mixing the sample blocks with a compound digestive enzyme, and filtering to obtain a single-cell suspension after digestion treatment is completed; wherein the compound digestive enzyme is prepared from collagenase, hyaluronidase and papain; and selectively, S3, carrying out red removing treatment. The invention not only provides an improved preparation method of the single-cell suspension, but also has higher efficiency on the premise of ensuring the yield and activity of single cells, and provides a new strategy and tool for cancer research and treatment by particularly enriching CSCs.

Systems and methods for safety assessment before and during a transcranial ultrasound (TUS) procedure are described. A neuronavigation system is used to determine the probe's position and orientation. The probe's location and the subject's head MRI data are used to simulate the acoustic field within the subject's head. The acoustic field is overlaid on the MRI data and displayed to a clinician for evaluation. The phases of the transmit voltages are adjusted to optimize the location of the peak of the acoustic field to match the targets in the subject's brain. Before and during TUS, the spatial distribution of tissue temperature, MI, TIC, and ISPTA are computed and displayed to the clinician. Acoustic field changes due to the subject's movement are detected, and the TUS operation is terminated if the stimulated acoustic field becomes off-target. Monitoring circuits shut down the neuromodulation if parameters are out-of-range.

The invention discloses a medical oncology implantable infusion port leakage monitoring system and method, and relates to the technical field of infusion leakage detection. The multi-parameter sensor module is used for monitoring pressure fluctuation in an infusion port, sensing temperature change of surrounding tissues, detecting abnormal leakage conditions of medicine components and obtaining multi-parameter sensor data; the flexible electronic circuit module is used for processing multi-parameter sensor data in real time; the data analysis and early warning module is used for performing real-time analysis on the processed multi-parameter sensor data and performing graded early warning; and the wireless communication module is used for transmitting the data of the multi-parameter sensor to an external terminal in real time by adopting a wireless communication technology. The invention relates to data acquisition, signal processing, feature extraction and fusion, leakage threshold judgment and response and feedback of an alarm mechanism, the accuracy of sensor data is ensured by applying a multi-modal fusion algorithm, and the safety and medical response efficiency of a patient are improved through a graded early warning mechanism.

The invention provides an ultrasonic cutter parameter optimization method for frozen tissue slicing, and belongs to the technical field of medical instruments. The ultrasonic cutter parameter optimization method for the frozen tissue section comprises the following steps: collecting vibration frequency, amplitude, feeding speed, load power and cut tissue type in a frozen tissue cutting process of an ultrasonic cutter as an initial parameter group, and establishing a mapping relation between the initial parameter group and frozen tissue temperature change; calculating a contribution value of the initial parameter group, comparing the contribution value with a preset threshold value, determining the parameter group greater than the preset threshold value as a key parameter group, and determining the parameter group less than or equal to the preset threshold value as a non-key parameter group; by means of the ultrasonic knife, the problem that an existing ultrasonic knife cannot achieve accurate control over temperature changes in the tissue slicing process can be solved.

The invention discloses an interventional therapy path planning system based on ultrasonic imaging, and relates to the technical field of interventional therapy systems.An image acquisition module acquires a two-dimensional or three-dimensional ultrasonic image of an operation area, and standardized input of image data is achieved; the structure identification module executes a medical image segmentation task based on the ultrasonic image and identifies a key anatomical structure in the image; the geometric modeling module constructs a three-dimensional space model according to the structure recognition result; the thermal simulation prediction module comprises a heat conduction simulation sub-module and a thermal parameter dynamic adjustment sub-module; the temperature feedback module reconstructs a three-dimensional temperature field image in the target tissue based on the tissue temperature feedback signal; the parameter updating module executes real-time updating of heat conduction parameters based on the residual error between the predicted temperature field and the observation temperature field collected by the temperature feedback module; the problems that in existing interventional therapy, thermal control precision is low, path planning depends on experience, and tissue dynamic changes are difficult to deal with are effectively solved.

The invention relates to the technical field of medical instruments, in particular to a method and equipment for controlling a tissue temperature field through radio frequency power. The method comprises the steps that S1, radio frequency treatment equipment has a pre-output state, and the pre-output state is that radio frequency energy and a refrigerant are controlled to be output according to default numerical values; s2, the radio frequency treatment equipment further has a model control state, and the model control state is that radio frequency energy and a refrigerant are controlled through a default model, an adjusting model and a stable model; the default model is a preset temperature model; the adjusting model is detected through the detection mechanism, and radio frequency energy parameters are adjusted on the basis of the default model according to detection data; and the stable model combines the static state of the default model and the dynamic change of the adjustment model so as to judge whether the adjustment model is stable or not. According to the method, the radio frequency energy is accurately controlled, so that the temperature of the radio frequency energy acting on the target tissue layer is controllable, the change of the radio frequency energy corresponds to the change of a tissue subcutaneous temperature field, and the radio frequency energy output can achieve an ideal acting effect.

The invention belongs to the technical field of medical equipment, and provides a bipolar electrotome control method and device, electrosurgical equipment and a storage medium, and the method comprises the steps: obtaining an output voltage, an output current and a tissue temperature; determining a feature vector based on the output voltage, the output current and the tissue temperature; inputting a plurality of feature vector values in the feature vectors into a trained full-connection neural network to obtain a closure degree predicted value, a carbonization risk predicted value and a quality score predicted value; determining a dynamic output power based on the closure degree predicted value, the carbonization risk predicted value, a feature vector and a basic output power; based on the dynamic output power and a preset condition, determining a safe output power through a safe output power calculation formula; controlling the closing action of the bipolar electrotome based on the closing degree predicted value, the safe output power and the closing quality score value; the efficiency of controlling the bipolar electrotome to perform the closing action is improved, the problem of excessive carbonization of tissues is reduced, and the operation safety is greatly improved.

There is provided a process for treatment of rhinitis by diode laser ablation of the branches of the posterior nasal nerve. The diode laser delivery device with elongated fiber optic with its fiber tip is inserted through a patient's nostril and has the length, flexibility and a curvature to reach both above and under the patient's middle turbinate for treatment of both branches of the posterior nasal nerves. Skin and tissue temperature is raised to approximately 60-70° C. with the process. A control knob on the laser delivery device moves from a first to a second position to move a camera attached to the laser delivery device. The fiber optic includes a distal fiber tip extending from a malleable sheath connected to the body for delivering light energy to a treatment area.

The invention discloses a radio frequency thermal therapy equipment testing system, relates to the technical field of equipment testing, and is used for solving the problems that the uncertainty in the energy transmission process is increased, and the system output stability and response precision are reduced. The output power is calculated in combination with an analog multiplier, and difference analysis is carried out in cooperation with ideal power; meanwhile, performing fast Fourier transform on the original signal to extract a frequency concentration ratio, and calculating a heat concentration coefficient; the tissue temperature at a needle is monitored based on an optical fiber fluorescence sensor, fluorescence detection temperature and observation temperature values are calculated in combination with fluorescence lifetime, difference analysis is performed to obtain a thermal response deviation factor, and the two values are fused to obtain a feedback calibration result for equipment performance optimization, and real-time monitoring of an energy state and abnormal heat accumulation identification are realized.

The invention relates to the technical field of medical imaging treatment, in particular to a laser ablation collaborative diagnosis and treatment device based on small animal thermal image real-time feedback. Comprising a diagnosis and treatment cavity, a laser point focusing incidence module, a tumor thermal imaging module, a machine vision imaging module, an automatic tracking and aligning laser module and a small animal gaseous anesthesia module, the laser point focusing incidence module and the tumor thermal imaging module are aligned with the automatic tracking alignment laser module, the machine vision imaging module is arranged above the diagnosis and treatment cavity, the bottom of the machine vision imaging module extends into the diagnosis and treatment cavity, and the small animal gaseous anesthesia module is connected with the diagnosis and treatment cavity through a pipeline. The device monitors and feeds back the temperature of tissues in the small animal body in real time in the treatment process, laser ablation parameters are dynamically adjusted according to thermal imaging data, and the treatment accuracy and the treatment effect are improved. The method is mainly applied to laser ablation collaborative diagnosis and treatment of thermal image real-time feedback.

Systems and methods for ablating target tissue, measuring parameters during ablation such as temperature of the target tissue, and predicting volume of the ablation based on the measured parameters are provided. The system may include a switching antenna for both heating of target tissue and radiometry to monitor the temperature of the heated tissue, and a processor for calculating the temperature of the target tissue, segmenting medical images, and predicting volume of the ablation based on radiometric signals indicative of the target tissue temperature. The predicted ablation volume may be adapted to account for tissue boundaries and anatomical structures. The processor further may determine properties of the target tissue such as tissue type.

Systems and methods for ablating target tissue, measuring parameters during ablation such as temperature of the target tissue, and predicting volume of the ablation based on the measured parameters are provided. The system may include a switching antenna for both heating of target tissue and radiometry to monitor the temperature of the heated tissue, and a processor for calculating the temperature of the target tissue, segmenting medical images, and predicting volume of the ablation based on radiometric signals indicative of the target tissue temperature. The predicted ablation volume may be adapted to account for tissue boundaries and anatomical structures. The processor further may determine properties of the target tissue such as tissue type.

The invention relates to nervonic acid-loaded near-infrared light response type injectable hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological engineering. According to the invention, P (NIPAM-co-NHMAM) and a modified natural polymer material are combined to prepare a temperature-responsive hydrogel capable of realizing reversible volume shrinkage / expansion at a specific temperature, near-infrared light physiotherapy and irradiation are combined to damage local skin, and the hydrogel is stimulated to realize reversible volume deformation by controlling tissue temperature, so that the temperature-responsive hydrogel can be used for preparing the hydrogel with the reversible volume shrinkage / expansion at the specific temperature. Therefore, accurate and wireless space-time regulation and control of nervonic acid release behaviors are realized. Therefore, the nervonic acid loaded near-infrared light response type injectable hydrogel disclosed by the invention can realize efficient carrying and light response controllable release of nervonic acid, promotes functional recovery after spinal cord injury, and has a relatively good application prospect and research significance.

The utility model discloses a plasma operation electrode cutting in-vitro tissue temperature test platform, which comprises a plasma host, a plasma operation electrode, a temperature measurement console, a temperature recorder, a time synchronization controller and a computer, and is characterized in that the plasma operation electrode is connected with an operation electrode interface of the plasma host through a lead; according to the test platform, the plasma operation electrode can be conveniently clamped and fixed by arranging the adjusting sliding block, the annular clamping frame and the anti-skid layer, and the spatial position of the plasma operation electrode clamped and fixed by the electrode clamping mechanism can be conveniently and accurately adjusted in the x direction, the y direction and the z direction by arranging the supporting column, the connecting sleeve, the connecting block, the positioning bolt and the connecting rod; the depth of the plasma operation electrode tool bit fixed on the electrode clamping mechanism inserted into the in-vitro tissue and the distance between the plasma operation electrode tool bit and the temperature measuring probe can be conveniently controlled, so that temperature data of different depths in the in-vitro tissue can be conveniently measured, and the temperature of the in-vitro tissue can be conveniently and accurately measured.

The invention discloses a pressure monitoring device and method for evaluating pressure sore risk, and relates to the technical field of medical equipment. The system comprises a pressure sensing unit used for collecting pressure distribution data between the body surface of a patient and a supporting surface; the distance measuring device is used for measuring the distance between the device and the body surface of the patient. According to the method, information of three different dimensions of pressure distribution, body surface image and deep thermal imaging is subjected to fusion analysis, a pressure sensor positions a high-risk pressed area, a high-definition color image is used for identifying macroscopic skin damage and color change, infrared thermal imaging can penetrate through a surface layer, and the image can be used for identifying the skin damage and color change. According to the method, deep tissue temperature abnormity caused by ischemia and inflammation is sensitively captured, and the three types of information are integrated into a quantitative comprehensive risk score through a weighting algorithm, so that an evaluation result does not depend on subjective experience of nursing personnel any more and is converted into objective and quantifiable accurate diagnosis, and the screening accuracy of high-risk patients is remarkably improved.

A surgical device, comprising a handle including at least one user input mechanism and a shaft extending distally from the handle, the shaft including a distal end. In examples, a thermal assembly can be operably coupled to the distal end of the shaft, including a heating element, wherein the thermal assembly includes at least one heating element and is electrically coupled to the at least one user input mechanism. In examples, a temperature monitoring mechanism can be coupled to the handle, wherein the temperature monitoring mechanism includes temperature monitoring technology such that a temperature of at least one of the thermal assembly or a targeted tissue area of a patient is monitored during a procedure with the surgical device, wherein the temperature monitoring technology includes Fiber Bragg Grating technology.

A method for controlling tissue temperature involves providing a nasal cannula including a first elongated prong with an axial fluid channel and a downwardly-curved shape. The nasal cannula further includes a first aperture on a side wall of a distal portion of the first elongated prong. The first aperture provides access to the axial fluid channel. The method includes inserting the first elongated prong into a nasal cavity of a subject to face the first aperture at a pharyngeal wall of the subject and modifying a temperature of the pharyngeal wall by delivering a first fluid portion through the axial fluid channel and out of the first aperture to the pharyngeal wall.

This present disclosure provides devices, systems, and methods relating to the modulation of tissue temperature. In particular, the present disclosure provides devices, systems, and methods for rapidly cooling or heating tissue in a subject as a therapeutic and / or prophylactic means for treating tissue that has been injured or damaged.

The present invention provides a high-peak tunable thulium-doped fiber laser system based on supercapacitor energy supply, which involves the use of stimulated emission modulation technology. It intelligently selects the most suitable laser output mode according to the hardness of the stone and the blood oxygen status of the tissue; and automatically switches to the thulium laser continuous wave hemostasis mode when the hemoglobin deoxygenation ratio and tissue temperature rise exceed the standard to ensure surgical safety; secondly, combined with supercapacitor energy supply technology, the system has high-peak and low-latency energy release capabilities, significantly improving the lithotripsy efficiency. At the same time, through a closed-loop control mechanism, the laser parameters are fine-tuned in real time to avoid the "flash" phenomenon and reduce surgical risks.

In part, the disclosure relates to an electromagnetic radiation (EMR) delivery system for non-invasive surface tissue temperature monitoring. The system includes a first source of EMR having a first wavelength range; a second source of EMR having a second wavelength range; and a tissue contacting material comprising a set of wavelength range specific EMR responsive dopants. In various embodiments, the tissue contacting material is positioned on a surface of a target region of tissue, wherein the tissue contacting material receives EMR from the first source, wherein the tissue contacting material receives EMR from the second source. The first and second sources may be arranged in different ori-entations or along a common axis or orientation.

Systems and methods for measuring cable pollution to accurately measure parameters during ablation such as temperature of the target tissue for safe and efficacious ablation of target tissue are provided. For example, the systems described herein comprise a switch, e.g., a Dicke switch, a radiometer, and a reference termination positioned at a proximal side of a coaxial cable connecting a generator to a catheter comprising a microwave antenna, and a diode circuit positioned at a distal side of the coaxial cable, e.g., within a handle of the catheter. The diode circuit may be biased to a closed state to create a short circuit at the distal end of the cable to thereby isolate the contribution of the cable to the radiometric signals traveling through the cable, e.g., cable pollution, which may be used to compute the target tissue temperature.

The invention relates to a method for determining a switch-off time for a medical device, comprising the steps of measuring the duration of a tissue temperature above 85°C, preferably above 95°C, preferably calculating online the average temperature from the first time the temperature reaches 85°C, preferably 95°C, measuring and / or calculating the energy input until the temperature reaches 85°C, preferably 95°C, and preferably below 110°C, preferably below 100°C, and calculating a parameter SP that correlates the above results and switches off at a predetermined value. The invention also relates to a medical device, a use, and a storage medium according to the coordinated claims.

A system includes an energy-based surgical instrument having an end effector with two electrodes. One of the electrodes has multiple electrode portions. A generator coupled to the surgical instrument supplies radio frequency (RF) energy to the electrode portions for a tissue coagulation process, and further supplies RF energy at a higher voltage or current to the other electrode portion for a tissue transection process. Control elements monitor tissue impedance or tissue temperature. Other embodiments are described and claimed in this invention.

The invention discloses a multi-sensor joint feedback radiofrequency ablation morphology prediction system, and relates to the technical field of radiofrequency ablation minimally invasive therapy, and the system specifically comprises an ablation signal collection module which processes a signal through a distributed temperature sensor and an impedance detection path and through low-pass filtering and moving average processing; reconstructing a continuous and smooth tissue temperature field from the discrete temperature data; the core parameter calculation module is used for calculating core state parameters based on the temperature field and impedance data, setting a dynamic carbonization threshold value and a carbonization risk index, constructing a real-time necrosis degree index, presenting a necrosis area through a thermodynamic diagram and defining an ablation front edge; and the power self-adaptive closed-loop regulation and control module is used for predicting tissue state change, solving optimal test power through a target optimization function, adding carbonization risk constraint and power boundary limitation, dynamically adjusting output power, periodically updating tissue state data and repeating the whole process to form a closed loop so as to realize self-adaptive regulation and control of the ablation process.

A surgical device includes a handle including at least one user input mechanism and a shaft extending distally from the handle, the shaft including a distal end. In an example, a thermal assembly may be operably coupled to a distal end of a shaft, the thermal assembly including a heating element, where the thermal assembly includes at least one heating element and is electrically coupled to at least one user input mechanism. In an example, a temperature monitoring mechanism may be coupled to a handle, where the temperature monitoring mechanism includes a temperature monitoring technique such that a temperature of at least one of a thermal assembly or a target tissue region of a patient is monitored during a procedure performed with a surgical device, where the temperature monitoring technique includes a fiber Bragg grating technique.

The present invention relates to a treatment device using RF energy and a control method thereof, and provides a treatment device using RF energy and a control method thereof, the treatment device comprising: an RF generation unit; an electrode unit that comes into contact with the skin of a patient and applies, to tissue, a plurality of RF pulses generated from the RF generation unit; a temperature measurement unit for measuring temperature information of the tissue, to which the RF pulses are being applied, while the RF pulses are being applied; and a control unit for controlling parameters of the RF pulses on the basis of the temperature information measured by the temperature measurement unit.

The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.

The invention provides a high-peak tunable thulium-doped fiber laser system based on energy supply of a super capacitor, relates to the technical field of modulation by utilizing stimulated emission, and intelligently selects a most suitable laser output mode according to the hardness of stones and the blood oxygen state of tissues; when the hemoglobin deoxidation ratio and the tissue temperature rise exceed the standard, the mode is automatically switched to the thulium laser continuous wave hemostasis mode, and the operation safety is ensured; secondly, in combination with a super-capacitor energy supply technology, the system has high-peak and low-delay energy release capacity, the lithotripsy efficiency is remarkably improved, meanwhile, laser parameters are finely adjusted in real time through a closed-loop control mechanism, the explosion flash phenomenon is avoided, and the surgical risk is reduced.

The ablation electrode with the temperature prompting function comprises a handle, a plug is arranged at one end of the handle, a cutter bar is arranged at the other end of the handle, a loop electrode, an insulator and a working electrode are arranged at the front end of the cutter bar, and a temperature feedback mechanism is further arranged at the front end of the cutter bar. And the temperature feedback mechanism displays a visible signal at the front end of the cutter bar. According to the technical scheme, the temperature feedback mechanism is arranged at the front end of the cutter bar, and when the temperature exceeds the preset value, the temperature feedback mechanism displays a visual signal at the front end of the cutter bar, so that a doctor can visually receive a temperature prompt under an endoscope; therefore, the purpose of prompting the temperature of fluid or tissue around the ablation area of the ablation electrode is achieved, and thermal damage is reduced.