75 results about "Prostatic tissue" patented technology

The prostate stent conveyor with the balloon particularly relates to the technical field of medical instruments and comprises an outer tube, an inner tube coaxial with the outer tube is arranged in the middle of an inner cavity of the outer tube, the inner cavity at the left end of the inner tube is rotationally connected with a rotating assembly, and the right end of the rotating assembly is fixedly connected with a sliding assembly. The middle of the sliding assembly is fixedly connected with a guide rod, the outer surface of the guide rod is sleeved with an elastic assembly, a first guide pipe is arranged in an inner cavity of the inner pipe, the right end of the first guide pipe is fixedly connected with a balloon communicated with the inner cavity, and the inner wall of the outer pipe is fixedly connected with a guide-in assembly. According to the prostate stent conveyor with the balloon, a prostate stent can be fixed in the inner tube to be conveyed by arranging the inner tube, the stent is prevented from damaging prostate tissue of a patient in the conveying process, the stent can be fixed in the conveying process by arranging the balloon, after the stent is conveyed to a set position, the balloon is blown firstly, and then the balloon is blown to the set position. Therefore, the pain of the patient can be relieved.

The invention discloses application of a reagent for detecting REEP protein in preparation of a product for diagnosing prostatic cancer, and relates to the technical field of biological medicine. Proteome analysis on urine proteins of a prostate cancer patient and a normal male and immunohistochemical analysis on archive wax blocks and surrounding normal prostate tissues of the prostate cancer patient find that REEP5 and REEP6 proteins are highly expressed in the prostate cancer tissues, and the content of REEP5 and REEP6 proteins in urine is higher than that of the normal group; the REEP5 protein and the REEP6 protein have a certain relationship with occurrence and development of the prostate cancer, are helpful for diagnosis of the prostate cancer and are also helpful for detection and diagnosis of noninvasive urine prostate cancer, and through research on the relationship between the REEP5 protein and the REEP6 protein and the prostate cancer, the diagnosis rate of a patient is increased, early discovery and early treatment are realized, postoperative noninvasive review, medication guidance and self-test are also facilitated, and the prostate cancer diagnosis method is suitable for clinical application. The survival rate and the cure rate are improved.

The utility model relates to an electric resection loop and a prostate resection mirror thereof. The electric resection loop is of an inwards-sunken spade-shaped structure and comprises a first electric resection part and a second electric resection part, the first electric resection part is provided with a first arc-shaped part, the curvature of the middle position of the first arc-shaped part is larger than or equal to the curvature of the two sides of the first arc-shaped part, one side of the first electric resection part is connected with one side of the second electric resection part, and the other side of the first electric resection part is connected with the second electric resection part. And a through hole is formed in the second electric cutting part. The electric resection loop is arranged to be of the plate-shaped structure which is concave inwards, the first arc-shaped part is arranged on the first electric resection part, and therefore the electric resection loop can be inserted into a prostate surgery envelop plane more easily and is not prone to deformation, in addition, the electric resection loop is designed to be of the spade-shaped structure, and compared with an annular structure, the electric resection loop is more convenient to use. The spade-shaped structure has higher strength, so that when the electric resection loop is used for pushing prostate tissue, the electric resection loop is not prone to deformation, the electric resection loop can be protected in the operation process, and smooth operation is facilitated.

The invention provides a traditional Chinese medicine composition for preventing or treating prostatitis and a preparation method and application thereof, and belongs to the technical field of health care medicines. The traditional Chinese medicine composition is prepared from the following components: semen plantaginis, herba taraxaci, radix sophorae flavescentis, cortex phellodendri, radix salviae miltiorrhizae, radix et rhizoma rhei, radix rehmanniae praeparata, fructus ligustri lucidi, semen cuscutae, herba cistanche, fructus lycii extract, longan extract, membrane of hen egg, fructus ziziphi jujubae extract, honey and rice fermentation filtrate. The traditional Chinese medicine composition is in a liquid dosage form prepared by a process including fermentation treatment. The traditional Chinese medicine composition prepared by the invention can relieve prostate tissue edema of a prostatitis model rat in a dose-dependent manner and reduce a prostate wet weight index, so that the traditional Chinese medicine composition has a certain improvement effect on prostate tissue hyperplasia and inflammatory swelling caused by chronic abacterial prostatitis.

The invention discloses a prostate therapeutic instrument, and belongs to the technical field of medical instruments. A massage head slides at the front end of the shell, and a plurality of guide sliding grooves are evenly distributed in the massage head. A center column is fixed to the center of the shell, and a first disc body and a second disc body are arranged on the center column. A plurality of sliding sleeves are arranged between the first disc body and the second disc body in a circumferential array mode, connecting blocks are arranged on the multiple sliding sleeves, each connecting block is arranged in the corresponding guide sliding groove, and air cavities are formed in the multiple sliding sleeves; wherein a plurality of stand columns are arranged on the first disc body in the circumferential direction in an array mode, the stand columns are inserted into the corresponding air cavities in a sliding mode respectively, and each stand column is connected with an air pipe. Through an inflation and deflation circulation system driven by a micro air pump, the sliding sleeves can be regularly pushed to reciprocate along the stand columns, and then the massage heads are driven to generate displacement; pulse type mechanical stimulation on a prostate focus part is formed; the dynamic pressing can effectively promote microcirculation of prostate tissues.

The application discloses application of a reagent for detecting AHSP protein in preparation of a product for diagnosing prostate cancer, and relates to the technical field of biological medicine; through proteomic analysis, ELISA test on urine protein of prostate cancer patients, clear cell renal cell carcinoma patients and normal healthy men, and immunohistochemical analysis on file wax blocks of the prostate cancer patients, normal prostate tissues around the cancer, prostate tissues of prostatic hyperplasia and clear cell renal cell carcinoma tissues, it is found that the AHSP protein has a certain relationship with the occurrence and development of prostate cancer, and can be used for assisting diagnosis of the prostate cancer; and in urine detection, AHSP has higher sensitivity than PSA, and when PSA is negative or serum PSA is low, AHSP can form complementation with ASHP, thereby helping to improve the diagnosis rate and non-invasive screening ability; through research on the relationship between the AHSP protein and the prostate cancer, the diagnosis rate of patients can be improved, non-invasive reexamination after treatment is facilitated, drug use is guided, and the survival rate is improved.

The use of a Reyanning formulation in the preparation of a drug for preventing and treating prostatitis. The Reyanning formulation is prepared from dandelion, giant knotweed rhizome, sonchi arvensis herba and herba scutellariae barbatae. The present application finds that the Reyanning formulation can reduce the contents of IL-6, IL-1β, NO and MDA in the serum of model rats, HE staining results show that the Reyanning formulation has certain relieving effect on the damage of prostate tissue, and it can be concluded from the molecular and tissue levels that the Reyanning formulation has certain prevention and treatment effect on chronic non-bacterial prostatitis.

Devices and systems are disclosed for managing and / or treating body tissues obstructing a hollow body lumen, including the prostatic lobe tissues obstructing the urethra, for example conditions including benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), benign prostatic obstruction (BPO) and associated lower urinary tract symptoms (LUTS). An implant is maintained in a constrained configuration within a distal portion of an elongated sheath so that is may be deployed by driving the implant with a pusher coaxially disposed within the sheath. An implant engaging element helps maintain control of the implant during deployment.

The invention provides an ablation device and a prostate tissue ablation system.The ablation tissue comprises a head electrode assembly, a needle electrode assembly and a handle assembly, the head electrode assembly comprises a head end main body and an outer tube which are connected with each other, the head end main body is arranged at the far end of the outer tube, a head electrode is arranged at the far end of the head end main body, and the needle electrode assembly is arranged on the outer tube. A needle electrode channel is arranged in the outer tube, the needle electrode assembly is contained in the needle electrode channel, the needle electrode assembly comprises at least one needle electrode, and the needle electrode assembly extends out of the side face of the ablation device based on operation on the handle assembly. According to the embodiment of the invention, the interventional operation of entering the urethra through a natural orifice and operating under a visual working condition and adopting an irreversible electroporation steep pulse electric field with tissue selectivity can be realized, so that the operation efficiency and the operation safety and effectiveness are greatly improved.

A medical water jet scalpel system is provided with an insertion part and a handle part connected to the near end of the insertion part, and the medical water jet scalpel system comprises a water jet scalpel assembly, a laser assembly and a suction control assembly. The water jet assembly comprises a water jet channel penetrating through the insertion part and the handle part and is configured to output jet flow; the laser assembly comprises a laser channel penetrating through the insertion part and the handle part and is configured to output laser energy; the aspiration control assembly includes an aspiration channel through the insertion portion and the handle portion configured to aspirate fluid. According to the medical water jet scalpel instrument, the water jet scalpel technology and the laser technology are combined, prostate tissue excision can be carried out under the condition of no thermal damage, and meanwhile hemostasis is achieved; in addition, the medical water jet scalpel instrument can complete the whole operation at the same time, surgical instruments do not need to be replaced midway, operation is easy, and the learning curve is short.

Implantable devices for retracting prostatic tissue of a patient are provided. In some embodiments, an implantable device may include a main body and a suture extending through at least a portion of the main body. The main body may be configured to extend through prostatic tissue of the patient such that a distal end portion of the main body resides at least partially outside of a prostatic capsule of the patient, and the distal end portion may be configured to deform from an undeformed configuration to a deformed configuration. The suture may include a first end and a second end extending from a proximal end of the main body, and the suture may be configured to cause the distal end portion to deform from the undeformed configuration to the deformed configuration when the first end and the second end are pulled proximally relative to the main body.

The utility model discloses an in-vitro prostate pathological tissue positioning identification and sampling device, which relates to the technical field of medical instruments and comprises a support component, a positioning guide component and a plurality of positioning needles. The support assembly comprises a supporting plate and a positioning column, and the positioning column is used for penetrating through the urethra of the prostate to fix the prostate; the positioning and guiding assembly is installed on the support assembly, and scales used for positioning the tumor position in the prostate body are arranged on the positioning and guiding assembly; and the plurality of positioning needles are used for positioning and identifying focuses in the prostate body. Through the arrangement, the preoperative mpMRI image of a patient and a 3D reconstructed digital model can be used as input, and the position of a tumor in a gland can be accurately positioned again under the condition that the prostate tissue is in vitro through the assistance of the in-vitro prostate pathological tissue positioning identifier and the sampling device; therefore, the target tumor tissue can be quickly and accurately taken out from the in-vitro prostate.

The invention provides a construction method of a prediction model for prostate cancer malignancy risk and a prediction system, and the method comprises the following steps: S1, collecting sample data of hereditary variation of a subject, including mutation allelic dose of variation; s2, taking an intersection of the sample data of the heritable variation of the subject in the step S1 and a prostatic cancer GWAS site SNP set in UKBB; s3, calculating the correlation between the genetic mutation of the intersection in S2 and the activity of 3beta HSD1; s4, calculating the risk score of the subject; and S5, randomly selecting a plurality of genetic variations for multiple times, repeating the step S4, calculating to obtain a plurality of PRSs, and calculating a genetic variation fingerprint score. According to the construction method of the prediction model for the malignant risk of the prostate cancer and the prediction system, the tissue with high 3beta HSD1 enzyme activity and the tissue with low 3beta HSD1 enzyme activity are subjected to multi-omics sequencing, and genetic variation fingerprints are established to represent the metabolic activity of the 3beta HSD1 of the prostate tissue; the biomarker can be provided for doctors as an efficient biomarker for early diagnosis of prostatic cancer.

This invention discloses the application of SNCG protein in the auxiliary diagnosis of prostate cancer, belonging to the field of biomedical technology. The application involves using reagents specifically designed to detect SNCG protein expression in biological samples to prepare products for the auxiliary diagnosis of prostate cancer. Through proteomic analysis of urinary proteins from prostate cancer patients and normal men, this invention revealed that the concentration of SNCG protein in the urine of prostate cancer patients was significantly higher than that in the normal male group. Immunohistochemical analysis of paraffin-embedded tissue samples from prostate cancer patients and surrounding normal prostate tissue showed that SNCG protein has a certain expression rate in prostate cancer, and that SNCG protein is also expressed in the basal cells of normal prostate glands, indicating a certain relationship between SNCG protein and the occurrence and development of prostate cancer. This invention can be used to assist in the diagnosis of prostate cancer and difficult cases, thereby improving the diagnosis rate and survival rate of patients.

This patent document discloses devices, systems, and associated methods for cutting, manipulating, and stabilizing tissue. A system for manipulating tissue in a prostatic urethra includes a handle body having a deployment actuator or a cutter actuator, along with an inflation port. An elongate member is coupled to a distal end of the handle body, and an expandable member is coupled to a distal end of the elongate member, which also includes a delivery body or a cutter body. The expandable member is configured to stabilize the delivery body or the cutter body against target tissue when the expandable member is expanded. A tissue manipulation structure, such as a cutter, is configured to move from a first position to a second position in which at least a portion of the structure extends into the surrounding prostatic tissue.

Implantable devices for retracting prostatic tissue of a patient are provided. In some embodiments, an implantable device may include a main body and a suture extending through at least a portion of the main body. The main body may be configured to extend through prostatic tissue of the patient such that a distal end portion of the main body resides at least partially outside of a prostatic capsule of the patient, and the distal end portion may be configured to deform from an undeformed configuration to a deformed configuration. The suture may include a first end and a second end extending from a proximal end of the main body, and the suture may be configured to cause the distal end portion to deform from the undeformed configuration to the deformed configuration when the first end and the second end are pulled proximally relative to the main body.

The invention provides an application of an aromatase gene CYP19A1 methylation level in evaluation of benign prostatic hyperplasia progress degree. The traditional Chinese medicine composition is used for treating benign prostatic hyperplasia patients from early progression; whether methylation and demethylation occur in CpG islands in promoter regions of aromatase genes CYP19A1 in prostate tissues of bladder cancer patients and elderly benign prostatic hyperplasia patients who are age-matched and subjected to radical bladder resection and prostatic resection are detected and analyzed, and whether methylation and demethylation occur in the CpG islands in the promoter regions of the aromatase genes CYP19A1 in the prostate tissues or not is judged; according to the present invention, the CYP19A1 gene methylation level is low and the CYP19A1 gene demethylation level is high in the prostate tissue of the early stage progression BPH patient, and the aromatase expression of the coding protein of the CYP19A1 gene is up-regulated, such that the aromatase gene CYP19A1 methylation change is related to the benign prostatic hyperplasia progress, and the new thought is provided for the risk stratification of the benign prostatic hyperplasia disease;

The application discloses a prostate puncture gun head for in-situ rotary cutting and a sampling method thereof, and belongs to the technical field of urological surgery. The needle head is arranged at the front end of the puncture gun and is used for penetrating into the prostate tissue; the blade groove is semicircular and is arranged along the longitudinal direction of the needle head; the blade is rotatably arranged in the blade groove and rotates along the track of the blade groove; the tissue groove is arranged on the surface of the needle head and is used for collecting the cut tissue sample; the knob spring device is connected with the blade and is used for providing rotary power to drive the blade to rotate and cut the prostate tissue along the blade groove. The knob spring device is used for driving the blade to rotate and move along the track of the semicircular blade groove, in-situ rotary cutting and sampling of the prostate tissue are realized, tissue tearing is effectively reduced, the flatness of the cutting surface is ensured, and the accuracy and efficiency of the sampling process are improved.

The invention belongs to the technical field of biological appliances for medical research, and particularly relates to a urinary surgery CP / CPPS model and a modeling method thereof. The modeling method comprises the following steps: (1) preparing prostate homogenate: taking rats of 4 months old, stripping prostate tissues under a sterile condition after the rats are killed, and grinding or homogenizing to prepare an injection suspension; (2) preparing a vaccine intraperitoneal injection: dissolving the inactivated vaccine freeze-dried powder into aluminum hydroxide gel normal saline to prepare the vaccine intraperitoneal injection; (3) injection of molding liquid: after anesthetizing the mouse, subcutaneously injecting prostate homogenate suspension, and intraperitoneally injecting vaccine intraperitoneal injection; and repeating the injection step until the mouse CP / CPPS model is formed. The modeling material disclosed by the invention can be conveniently purchased, the modeling material has common phenotypes of emotional abnormalities such as pain sensitization, anxiety, depression and the like of chronic pain after being molded, the phenotypes after modeling can be maintained for at least 90 days and can exceed half a year at most, the success rate of single-batch modeling is high, and the case fatality rate is low.

To provide a peri-vascular tissue ablation catheter capable of delivering an ablation liquid for circumferentially damaging tissue in or near an outer layer of a vessel of a human body.SOLUTION: Provided is an intravascular catheter for peri-vascular and / or periurethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and / or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also includes means to limit and / or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The preferred embodiment of the catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.SELECTED DRAWING: Figure 1

The utility model discloses a prostate puncture device which comprises a fixed handle, the center of the fixed handle is connected with a puncture needle, the center of the fixed handle is provided with a through hole, an ejector pin is inserted in the through hole, the ejector pin is also inserted in the puncture needle, the surface of the puncture needle is sleeved with a sheathing canal, and a pull rope is connected between the sheathing canal and the puncture needle. The pull rope is connected with a sleeve, the pull rope is inserted into the sleeve in a penetrating mode, the pull rope comprises a first thread end and a second thread end, one end of the first thread end is connected with a first spring ring, one end of the second thread end is connected with a second spring ring, and the first spring ring and the second spring ring are both made of memory metal. The prostate anchoring device solves the problem that an existing prostate anchoring device is limited through a needle head, so that the prostate is prone to being damaged, the needle head is replaced with the spring ring, the contact area between the prostate anchoring device and prostate tissue is increased, and pressure of the prostate tissue is reduced.

A medical water jet cutter system. The medical water jet cutter system is provided with an insertion portion (12) and a handle portion (11) connected to the near end of the insertion portion (12), and the medical water jet cutter system comprises a water jet cutter assembly, a laser assembly, and a suction control assembly. The water jet cutter assembly comprises a water jet cutter channel (101) penetrating through the insertion portion (12) and the handle portion (11) and is configured to output a jet. The laser assembly comprises a laser channel (201) penetrating through the insertion portion (12) and the handle portion (11) and is configured to output laser energy. The suction control assembly comprises a suction channel (401) penetrating through the insertion portion (12) and the handle portion (11) and is configured to suck a fluid. The medical water jet cutter instrument combines water jet cutter technology and laser technology and enables the resection of prostate tissue without thermal damage while achieving hemostasis. In addition, the medical water jet cutter instrument enables the use of one instrument to complete an entire operation; during the operation, there is no need to replace the surgical instrument. The medical water jet cutter instrument is simple to operate and has a short learning curve.

This invention discloses a prostate balloon dilation catheter, comprising a catheter body; a first balloon disposed outside the catheter body; and a blunt scoring body disposed along the axial direction of the first balloon on its surface, protruding from the surface of the first balloon, the blunt scoring body being used to press against a target location; wherein, in the uninflated state of the first balloon, the blunt scoring body is located at the fold position of the first balloon, the fold being a circumferential depression of the first balloon. This invention utilizes the blunt scoring body to press against the prostate tissue, creating stress concentration and thus assisting the anterior balloon in dilating the prostate at the target location. Compared to existing technologies, this effectively avoids the risk of scratches to the balloon and urethral wall.

The present invention discloses a preparation process and application of a compound preparation of astaxanthin, lycopene and proanthocyanidins for anti-aging and prevention of prostate diseases, belonging to the field of biomedicine. The preparation is composed of astaxanthin (1-10 parts), proanthocyanidins (5-30 parts), lycopene (2-15 parts), black cumin seed oil (0.5-3 parts), Phyllanthus emblica extract (3-8 parts) and Withania somnifera extract (1-5 parts), and is prepared by high-efficiency wet granulation technology. The components act synergistically to significantly enhance antioxidant, anti-inflammatory and anti-cancer activities, and have dual effects of anti-aging and prevention and treatment of prostate diseases. Experiments show that the hydroxyl radical scavenging rate of the compound preparation is 2.3 times higher than that of the single ingredient, the inflammatory factors in the prostatitis model are reduced by 68%, the skin antioxidant capacity is increased by 55%, and the combination with finasteride can reduce the dosage of chemical drugs by 80% and reduce the risk of sexual dysfunction. Black cumin seed oil significantly improves the bioavailability of lycopene (29.7%), and the drug concentration in the prostate tissue reaches 6.5 times that in the blood, achieving high efficiency with low dosage.

A prostatic implant configured to compress an enlarged prostate gland includes a distal anchor member and an expandable, proximal anchor member connected by a middle portion. The expandable, proximal anchor member is configured to expand upon being released from a tubular delivery device, such that the anchoring footprint of the expandable anchor member on the urethral side of a prostate gland is large relative to anchors having fixed dimensions. The expandable anchor member includes expandable portions configured to expand outwardly or laterally away from the body of the expandable anchor member, forming curved portions or wings. After anchoring the distal anchor member to the outer surface of the prostatic capsule, tension may be applied to the middle portion extended through the prostate gland. Attachment of the expandable anchor member to the middle portion at the urethral side of the gland locks the tension in place, retracting the enlarged prostatic tissue.

The invention relates to the technical field of medical instruments, in particular to an anchor for lifting prostate tissue. A rivet for lifting prostate tissue comprises a urethra end rivet, a film-coated end rivet and a fixing line, the urethra end rivet is connected with the film-coated end rivet through the fixing line, one end of the film-coated end rivet is a fixing pipe, the other end of the film-coated end rivet is an arc-shaped elastic piece, the urethra end rivet forms a V-shaped elastic clamp, and the V-shaped elastic clamp is connected with the film-coated end rivet. A plurality of limiting protrusions arranged at intervals in the length direction of the fixing line are arranged on the surface of the fixing line, and the limiting protrusions gradually extend towards the outer side of the circumference of the fixing line from the urethra end anchor nail side to the enveloping end anchor nail. The urethra end anchor has the advantage that a certain lifting effect is still achieved after the urethra end anchor is separated from the fixing line.

The application discloses a kind of prostatic stents, comprising: stent wire, it is outward convex circular arc line type structure;Elastic isolation membrane cover, including stent cover and isolation membrane piece, stent cover is installed on stent wire.The application also discloses two kinds of prostatic stent manufacturing method.Compared with prior art, the stent wire of existing prostatic stent is insufficient in compression state support, and the problem of complex film process is solved.The application also discloses a kind of prostatic stent with balloon, by making the balloon of stent body lumen, to realize supporting stent wire, make stent wire show greater support to prostate tissue.Prostate tissue is forced to expand by balloon long-term inflation or intermittent inflation, and the growth of stent wire is avoided after the expansion of prostate tissue.

The invention relates to a pharmaceutical composition of an extract of Agarophyton chilensis, with antiproliferative effect in prostate cancer, comprising(a) 0.1 to 90% of an oleoresin of Agarophyton chilensis, with the following major components: palmitic acid, arachidonic acid, oleic acid, stearic acid, meristic acid, linoleic acid; and(b) 10 to 99.9% excipients and formulation aids for different pharmaceutical forms.And its use to prepare a drug for the treatment or prevention of prostate cancer and other hyperproliferative states of prostate tissue cells.

This invention discloses a large-section kit for pathological prostate tissue, comprising an embedding cassette, an embedding mold, and a sample holder disposed within a storage box. The embedding cassette includes an embedding cassette body, a first partition, a first elastic clamping device, an embedding cassette lid, and a mounting ring. The bottom plate of the embedding cassette body, the embedding cassette lid, and the first partition are all plate structures with mesh openings. The pathologically obtained prostate tissue is placed between the first partition and the bottom plate of the embedding cassette body, and the elastic clamping device is disposed between the first partition and the embedding cassette lid. The embedding mold includes an embedding mold body, a second partition, and a second elastic clamping device. This invention can effectively improve the integrity and consistency of slide preparation, reduce specimen loss, and ensure the homogeneity of continuous step slides. Based on this, various specific staining methods can be performed, improving the reliability of pathological clinical diagnostic assessment and the objectivity of biological information diversity analysis in basic research, thereby reflecting the reliability of the gold standard for pathological testing.

Disclosed herein is a benign prostatic hyperplasia treatment device. The benign prostatic hyperplasia treatment device includes: anchor assemblies including a first anchor arranged at the outer surface of the prostate gland, which obstructs the prostatic urethra, a second anchor arranged inside the prostate gland to be opposed to the first anchor, and a ligature connecting the first anchor and the second anchor with each other so that the second anchor compresses the prostate tissue to secure the opening of the prostatic urethra; and a sheath inserted into the urethra and having a needle, which guides the anchor assembly to be deployed at the prostate gland.