41 results about "Prostatic tissue" patented technology

The utility model relates to an electric resection loop and a prostate resection mirror thereof. The electric resection loop is of an inwards-sunken spade-shaped structure and comprises a first electric resection part and a second electric resection part, the first electric resection part is provided with a first arc-shaped part, the curvature of the middle position of the first arc-shaped part is larger than or equal to the curvature of the two sides of the first arc-shaped part, one side of the first electric resection part is connected with one side of the second electric resection part, and the other side of the first electric resection part is connected with the second electric resection part. And a through hole is formed in the second electric cutting part. The electric resection loop is arranged to be of the plate-shaped structure which is concave inwards, the first arc-shaped part is arranged on the first electric resection part, and therefore the electric resection loop can be inserted into a prostate surgery envelop plane more easily and is not prone to deformation, in addition, the electric resection loop is designed to be of the spade-shaped structure, and compared with an annular structure, the electric resection loop is more convenient to use. The spade-shaped structure has higher strength, so that when the electric resection loop is used for pushing prostate tissue, the electric resection loop is not prone to deformation, the electric resection loop can be protected in the operation process, and smooth operation is facilitated.

The invention provides a traditional Chinese medicine composition for preventing or treating prostatitis and a preparation method and application thereof, and belongs to the technical field of health care medicines. The traditional Chinese medicine composition is prepared from the following components: semen plantaginis, herba taraxaci, radix sophorae flavescentis, cortex phellodendri, radix salviae miltiorrhizae, radix et rhizoma rhei, radix rehmanniae praeparata, fructus ligustri lucidi, semen cuscutae, herba cistanche, fructus lycii extract, longan extract, membrane of hen egg, fructus ziziphi jujubae extract, honey and rice fermentation filtrate. The traditional Chinese medicine composition is in a liquid dosage form prepared by a process including fermentation treatment. The traditional Chinese medicine composition prepared by the invention can relieve prostate tissue edema of a prostatitis model rat in a dose-dependent manner and reduce a prostate wet weight index, so that the traditional Chinese medicine composition has a certain improvement effect on prostate tissue hyperplasia and inflammatory swelling caused by chronic abacterial prostatitis.

The application discloses application of a reagent for detecting AHSP protein in preparation of a product for diagnosing prostate cancer, and relates to the technical field of biological medicine; through proteomic analysis, ELISA test on urine protein of prostate cancer patients, clear cell renal cell carcinoma patients and normal healthy men, and immunohistochemical analysis on file wax blocks of the prostate cancer patients, normal prostate tissues around the cancer, prostate tissues of prostatic hyperplasia and clear cell renal cell carcinoma tissues, it is found that the AHSP protein has a certain relationship with the occurrence and development of prostate cancer, and can be used for assisting diagnosis of the prostate cancer; and in urine detection, AHSP has higher sensitivity than PSA, and when PSA is negative or serum PSA is low, AHSP can form complementation with ASHP, thereby helping to improve the diagnosis rate and non-invasive screening ability; through research on the relationship between the AHSP protein and the prostate cancer, the diagnosis rate of patients can be improved, non-invasive reexamination after treatment is facilitated, drug use is guided, and the survival rate is improved.

The use of a Reyanning formulation in the preparation of a drug for preventing and treating prostatitis. The Reyanning formulation is prepared from dandelion, giant knotweed rhizome, sonchi arvensis herba and herba scutellariae barbatae. The present application finds that the Reyanning formulation can reduce the contents of IL-6, IL-1β, NO and MDA in the serum of model rats, HE staining results show that the Reyanning formulation has certain relieving effect on the damage of prostate tissue, and it can be concluded from the molecular and tissue levels that the Reyanning formulation has certain prevention and treatment effect on chronic non-bacterial prostatitis.

Devices and systems are disclosed for managing and / or treating body tissues obstructing a hollow body lumen, including the prostatic lobe tissues obstructing the urethra, for example conditions including benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), benign prostatic obstruction (BPO) and associated lower urinary tract symptoms (LUTS). An implant is maintained in a constrained configuration within a distal portion of an elongated sheath so that is may be deployed by driving the implant with a pusher coaxially disposed within the sheath. An implant engaging element helps maintain control of the implant during deployment.

Implantable devices for retracting prostatic tissue of a patient are provided. In some embodiments, an implantable device may include a main body and a suture extending through at least a portion of the main body. The main body may be configured to extend through prostatic tissue of the patient such that a distal end portion of the main body resides at least partially outside of a prostatic capsule of the patient, and the distal end portion may be configured to deform from an undeformed configuration to a deformed configuration. The suture may include a first end and a second end extending from a proximal end of the main body, and the suture may be configured to cause the distal end portion to deform from the undeformed configuration to the deformed configuration when the first end and the second end are pulled proximally relative to the main body.

The utility model discloses an in-vitro prostate pathological tissue positioning identification and sampling device, which relates to the technical field of medical instruments and comprises a support component, a positioning guide component and a plurality of positioning needles. The support assembly comprises a supporting plate and a positioning column, and the positioning column is used for penetrating through the urethra of the prostate to fix the prostate; the positioning and guiding assembly is installed on the support assembly, and scales used for positioning the tumor position in the prostate body are arranged on the positioning and guiding assembly; and the plurality of positioning needles are used for positioning and identifying focuses in the prostate body. Through the arrangement, the preoperative mpMRI image of a patient and a 3D reconstructed digital model can be used as input, and the position of a tumor in a gland can be accurately positioned again under the condition that the prostate tissue is in vitro through the assistance of the in-vitro prostate pathological tissue positioning identifier and the sampling device; therefore, the target tumor tissue can be quickly and accurately taken out from the in-vitro prostate.

This invention discloses the application of SNCG protein in the auxiliary diagnosis of prostate cancer, belonging to the field of biomedical technology. The application involves using reagents specifically designed to detect SNCG protein expression in biological samples to prepare products for the auxiliary diagnosis of prostate cancer. Through proteomic analysis of urinary proteins from prostate cancer patients and normal men, this invention revealed that the concentration of SNCG protein in the urine of prostate cancer patients was significantly higher than that in the normal male group. Immunohistochemical analysis of paraffin-embedded tissue samples from prostate cancer patients and surrounding normal prostate tissue showed that SNCG protein has a certain expression rate in prostate cancer, and that SNCG protein is also expressed in the basal cells of normal prostate glands, indicating a certain relationship between SNCG protein and the occurrence and development of prostate cancer. This invention can be used to assist in the diagnosis of prostate cancer and difficult cases, thereby improving the diagnosis rate and survival rate of patients.

Implantable devices for retracting prostatic tissue of a patient are provided. In some embodiments, an implantable device may include a main body and a suture extending through at least a portion of the main body. The main body may be configured to extend through prostatic tissue of the patient such that a distal end portion of the main body resides at least partially outside of a prostatic capsule of the patient, and the distal end portion may be configured to deform from an undeformed configuration to a deformed configuration. The suture may include a first end and a second end extending from a proximal end of the main body, and the suture may be configured to cause the distal end portion to deform from the undeformed configuration to the deformed configuration when the first end and the second end are pulled proximally relative to the main body.

The application discloses a prostate puncture gun head for in-situ rotary cutting and a sampling method thereof, and belongs to the technical field of urological surgery. The needle head is arranged at the front end of the puncture gun and is used for penetrating into the prostate tissue; the blade groove is semicircular and is arranged along the longitudinal direction of the needle head; the blade is rotatably arranged in the blade groove and rotates along the track of the blade groove; the tissue groove is arranged on the surface of the needle head and is used for collecting the cut tissue sample; the knob spring device is connected with the blade and is used for providing rotary power to drive the blade to rotate and cut the prostate tissue along the blade groove. The knob spring device is used for driving the blade to rotate and move along the track of the semicircular blade groove, in-situ rotary cutting and sampling of the prostate tissue are realized, tissue tearing is effectively reduced, the flatness of the cutting surface is ensured, and the accuracy and efficiency of the sampling process are improved.

The invention belongs to the technical field of biological appliances for medical research, and particularly relates to a urinary surgery CP / CPPS model and a modeling method thereof. The modeling method comprises the following steps: (1) preparing prostate homogenate: taking rats of 4 months old, stripping prostate tissues under a sterile condition after the rats are killed, and grinding or homogenizing to prepare an injection suspension; (2) preparing a vaccine intraperitoneal injection: dissolving the inactivated vaccine freeze-dried powder into aluminum hydroxide gel normal saline to prepare the vaccine intraperitoneal injection; (3) injection of molding liquid: after anesthetizing the mouse, subcutaneously injecting prostate homogenate suspension, and intraperitoneally injecting vaccine intraperitoneal injection; and repeating the injection step until the mouse CP / CPPS model is formed. The modeling material disclosed by the invention can be conveniently purchased, the modeling material has common phenotypes of emotional abnormalities such as pain sensitization, anxiety, depression and the like of chronic pain after being molded, the phenotypes after modeling can be maintained for at least 90 days and can exceed half a year at most, the success rate of single-batch modeling is high, and the case fatality rate is low.

The utility model discloses a prostate puncture device which comprises a fixed handle, the center of the fixed handle is connected with a puncture needle, the center of the fixed handle is provided with a through hole, an ejector pin is inserted in the through hole, the ejector pin is also inserted in the puncture needle, the surface of the puncture needle is sleeved with a sheathing canal, and a pull rope is connected between the sheathing canal and the puncture needle. The pull rope is connected with a sleeve, the pull rope is inserted into the sleeve in a penetrating mode, the pull rope comprises a first thread end and a second thread end, one end of the first thread end is connected with a first spring ring, one end of the second thread end is connected with a second spring ring, and the first spring ring and the second spring ring are both made of memory metal. The prostate anchoring device solves the problem that an existing prostate anchoring device is limited through a needle head, so that the prostate is prone to being damaged, the needle head is replaced with the spring ring, the contact area between the prostate anchoring device and prostate tissue is increased, and pressure of the prostate tissue is reduced.

A medical water jet cutter system. The medical water jet cutter system is provided with an insertion portion (12) and a handle portion (11) connected to the near end of the insertion portion (12), and the medical water jet cutter system comprises a water jet cutter assembly, a laser assembly, and a suction control assembly. The water jet cutter assembly comprises a water jet cutter channel (101) penetrating through the insertion portion (12) and the handle portion (11) and is configured to output a jet. The laser assembly comprises a laser channel (201) penetrating through the insertion portion (12) and the handle portion (11) and is configured to output laser energy. The suction control assembly comprises a suction channel (401) penetrating through the insertion portion (12) and the handle portion (11) and is configured to suck a fluid. The medical water jet cutter instrument combines water jet cutter technology and laser technology and enables the resection of prostate tissue without thermal damage while achieving hemostasis. In addition, the medical water jet cutter instrument enables the use of one instrument to complete an entire operation; during the operation, there is no need to replace the surgical instrument. The medical water jet cutter instrument is simple to operate and has a short learning curve.

This invention discloses a prostate balloon dilation catheter, comprising a catheter body; a first balloon disposed outside the catheter body; and a blunt scoring body disposed along the axial direction of the first balloon on its surface, protruding from the surface of the first balloon, the blunt scoring body being used to press against a target location; wherein, in the uninflated state of the first balloon, the blunt scoring body is located at the fold position of the first balloon, the fold being a circumferential depression of the first balloon. This invention utilizes the blunt scoring body to press against the prostate tissue, creating stress concentration and thus assisting the anterior balloon in dilating the prostate at the target location. Compared to existing technologies, this effectively avoids the risk of scratches to the balloon and urethral wall.

The invention relates to the technical field of medical instruments, in particular to an anchor for lifting prostate tissue. A rivet for lifting prostate tissue comprises a urethra end rivet, a film-coated end rivet and a fixing line, the urethra end rivet is connected with the film-coated end rivet through the fixing line, one end of the film-coated end rivet is a fixing pipe, the other end of the film-coated end rivet is an arc-shaped elastic piece, the urethra end rivet forms a V-shaped elastic clamp, and the V-shaped elastic clamp is connected with the film-coated end rivet. A plurality of limiting protrusions arranged at intervals in the length direction of the fixing line are arranged on the surface of the fixing line, and the limiting protrusions gradually extend towards the outer side of the circumference of the fixing line from the urethra end anchor nail side to the enveloping end anchor nail. The urethra end anchor has the advantage that a certain lifting effect is still achieved after the urethra end anchor is separated from the fixing line.

The application discloses a kind of prostatic stents, comprising: stent wire, it is outward convex circular arc line type structure;Elastic isolation membrane cover, including stent cover and isolation membrane piece, stent cover is installed on stent wire.The application also discloses two kinds of prostatic stent manufacturing method.Compared with prior art, the stent wire of existing prostatic stent is insufficient in compression state support, and the problem of complex film process is solved.The application also discloses a kind of prostatic stent with balloon, by making the balloon of stent body lumen, to realize supporting stent wire, make stent wire show greater support to prostate tissue.Prostate tissue is forced to expand by balloon long-term inflation or intermittent inflation, and the growth of stent wire is avoided after the expansion of prostate tissue.

The invention relates to a pharmaceutical composition of an extract of Agarophyton chilensis, with antiproliferative effect in prostate cancer, comprising(a) 0.1 to 90% of an oleoresin of Agarophyton chilensis, with the following major components: palmitic acid, arachidonic acid, oleic acid, stearic acid, meristic acid, linoleic acid; and(b) 10 to 99.9% excipients and formulation aids for different pharmaceutical forms.And its use to prepare a drug for the treatment or prevention of prostate cancer and other hyperproliferative states of prostate tissue cells.

This invention discloses a large-section kit for pathological prostate tissue, comprising an embedding cassette, an embedding mold, and a sample holder disposed within a storage box. The embedding cassette includes an embedding cassette body, a first partition, a first elastic clamping device, an embedding cassette lid, and a mounting ring. The bottom plate of the embedding cassette body, the embedding cassette lid, and the first partition are all plate structures with mesh openings. The pathologically obtained prostate tissue is placed between the first partition and the bottom plate of the embedding cassette body, and the elastic clamping device is disposed between the first partition and the embedding cassette lid. The embedding mold includes an embedding mold body, a second partition, and a second elastic clamping device. This invention can effectively improve the integrity and consistency of slide preparation, reduce specimen loss, and ensure the homogeneity of continuous step slides. Based on this, various specific staining methods can be performed, improving the reliability of pathological clinical diagnostic assessment and the objectivity of biological information diversity analysis in basic research, thereby reflecting the reliability of the gold standard for pathological testing.

The invention discloses a blunt enucleation and pulverization device for prostate tissue, and relates to the technical field of enucleation and pulverization of prostate tissue, the blunt enucleation and pulverization device comprises an enucleation and pulverization mechanism, the enucleation and pulverization mechanism is provided with a positioning adjustment mechanism, the bottom of the positioning adjustment mechanism is provided with an adsorption mechanism, and the enucleation and pulverization mechanism comprises an outer tube. According to the device, erecting support is provided through the U-shaped frame, the pneumatic telescopic rods are symmetrically connected to the top of the U-shaped frame, the telescopic air cylinders are connected to the tops of the pneumatic telescopic rods, and telescopic control of the telescopic air cylinders is utilized to facilitate telescopic adjustment of the outer pipe and adjustment of the penetrating depth, so that the enucleation operation depth is increased, the operation depth is guaranteed, and the enucleation efficiency is improved. The use flexibility is improved, and the operation effect is effectively improved. And an air pump is communicated through an air duct, so that the telescopic air cylinder can be conveniently controlled through the air pump, an effective telescopic adjustment function can be provided, and the operation convenience is improved.

The invention discloses a multifunctional radiofrequency ablation catheter for non-invasive treatment of prostatic hyperplasia through urethra and a synergistic device. The multifunctional radiofrequency ablation catheter and the synergistic device integrate the five functions of radiofrequency ablation, circulating cooling, catheterization flushing, balloon fixing and temperature sensing. The radiofrequency ablation system is composed of a radiofrequency generator, a circular-tube-shaped radiofrequency ablation electrode and a dispersion electrode. The cooling system is composed of a double-channel cooling circulation pipeline, an embedded temperature sensor, a peristaltic pump and a cold constant-temperature water tank. The urethral catheterization system comprises a drainage tube cavity, a flushing tube cavity, a balloon tube cavity and a front-end expandable balloon. The in-vitro control system is composed of an integrated multi-parameter monitoring module, a control panel and a data record. Based on the unique cognition that the radio frequency ablation metal electrode does not produce heat, precise ablation and catheterization flushing of hyperplastic prostate tissue are synchronously achieved through urethral intervention. The non-invasive radio frequency energy control and cooling technology can effectively protect the urethral mucosa, and has the advantages of efficient treatment, safe operation and rapid recovery.

The invention relates to an expansion device for prostate surgery. The expansion device comprises at least one first distraction unit, a first mounting unit, a first holding unit, at least one pressing unit, a second mounting unit, a second holding unit and a first locking unit. The device has the advantages that the relative positions of the first holding unit and the second holding unit are locked through the first locking unit, so that the first holding unit and the second holding unit get close to open the first opening unit and the pressing unit, and the first ends of the first opening unit and the pressing unit are both arranged to be arc-shaped; the pressing unit is arranged to be of a structure longer than the first distraction unit and is specially used for the prostate surgery, so that during the surgery, the first distraction unit can be utilized to safely support the abdominal wall of a patient, the arc-shaped structure of the pressing unit is utilized to press the prostate tissue, and a clear working space is created in the abdominal cavity; and an operation channel is provided through the second holding unit, CO2 does not need to be charged to establish pneumoperitoneum, the expansion operation is simple, and great convenience is provided for prostate operation.

The invention provides application of an LRG1 inhibitor or a miR-145-5p nano-complex in preparation of a medicine for preventing and / or treating prostatitis, and belongs to the technical field of biological medicine manufacturing. The invention discloses application of an LRG1 inhibitor in preparation of a medicine for preventing and / or treating prostatitis. In order to further improve the stability and the delivery efficiency of the miR-145-5p in vivo when the miR-145-5p is used as an LRG1 inhibitor, the invention provides a miR-145-5p nano-composite which is a polymer nano-particle loaded with the miR-145-5p. According to the invention, through targeted down-regulation of LRG1 and regulation and control of a TGF-beta / Smad signal channel, polarization of macrophages from M1 to M2 is remodeled, and oxidative stress of prostate tissues is synchronously relieved, so that mandatory treatment of prostatitis is realized.

This invention discloses a treatment device for benign prostatic hyperplasia that utilizes an anchor assembly and a needle. [Solution] The prostate enlargement treatment device according to the present invention includes a plurality of anchors positioned outside the prostate to compress the urethra, and a ligature that connects the plurality of anchors to each other so that the plurality of anchors continuously compress the prostate tissue to secure the prostatic urethra. The device may further include an elastic needle that houses the anchors and the ligature and guides them into the urethra so that they are placed in the prostate, and a needle launching means that launches the needle so that it is inserted into the urethra and is operated so that the plurality of anchors and the ligature are discharged through the needle.

A prostate puncture device capable of achieving ablation comprises an outer sheath, a rotary cutter and a microwave ablation probe, the outer sheath comprises a hollow sheath tube and a hollow connecting column, and a semi-cylindrical groove hole is formed in the outer side surface of the front portion of the hollow sheath tube; a hollow through hole is formed in the middle of the hollow connecting column; the rotary cutter comprises a connecting rod, the front end of the connecting rod is connected with a hollow pipe body, and a semi-cylindrical cutting notch is formed in the side surface of the hollow pipe body; the rear end of the connecting rod is fixedly connected with a rotating handle; the microwave ablation probe comprises a probe body and a limiting block, after the probe body is movably inserted into the hollow sheath tube, a radiation window of the probe body corresponds to the semi-cylindrical groove hole, and the limiting block is fixedly installed at the rear end of the probe body and movably connected into the hollow through hole. According to the utility model, the rotary cutter is firstly inserted into the hollow sheath tube to carry out precise rotary cutting on the prostate tissue to obtain an expected tissue sample, then the rotary cutter is withdrawn, and then the microwave ablation probe is inserted to carry out efficient ablation on a target area, so that on the premise of multiple sampling, the bleeding risk is reduced, and the defects in the prior art are overcome.

The invention provides a compound screening method and application of Cocumin granules in treatment of prostatitis, and belongs to the technical field of biology. According to the invention, main active components, key targets and pathways of the Cocumin granules are researched on the basis of network pharmacology, and compounds for potentially treating prostatitis, including quecetin, kaempferol and luteolin, are screened out. Meanwhile, on the basis of the research, the therapeutic action mechanism of the Cocumin granules on chronic bacterial prostatitis is analyzed, animal experiment verification is carried out, and the result shows that the Cocumin granules down-regulate expression of IL-1beta, IL-6, TNF-alpha, AKT and PI3K-AKT by regulating a PI3K-AKT signal channel, and improve prostate tissue inflammation.

Aspects of the disclosure relate to improved methods for predicting whether a prostate tissue biopsy obtained from a subject will contain detectable prostate cancer. In some embodiments, the disclosure provides improved prostate antigen standards for quantifying levels of prostate antigens.

A medical water jet scalpel system is provided with an insertion part and a handle part connected to the near end of the insertion part, and the medical water jet scalpel system comprises a water jet scalpel assembly, a laser assembly and a suction control assembly. The water jet assembly comprises a water jet channel penetrating through the insertion part and the handle part and is configured to output jet flow; the laser assembly comprises a laser channel penetrating through the insertion part and the handle part and is configured to output laser energy; the aspiration control assembly includes an aspiration channel through the insertion portion and the handle portion configured to aspirate fluid. According to the medical water jet scalpel instrument, the water jet scalpel technology and the laser technology are combined, prostate tissue excision can be carried out under the condition of no thermal damage, and meanwhile hemostasis is achieved; in addition, the medical water jet scalpel instrument can complete the whole operation at the same time, surgical instruments do not need to be replaced midway, operation is easy, and the learning curve is short.

Disclosed is a “benign prostatic hyperplasia surgical device using an anchor assembly and a needle. The benign prostatic hyperplasia surgical device includes a plurality of anchors disposed on the prostate gland compressing the urethra and a ligature thread connecting the plurality of anchors to each other so that the plurality of anchors continuously compress prostatic tissues to allow the urethra to be open. Further, the benign prostatic hyperplasia surgical device of the present invention includes: an elastic needle receiving the plurality of anchors therein and inserted into the urethra to guide the plurality of anchors and the ligature thread so that the plurality of anchors and the ligature thread are located on the prostate gland; and a needle launching means for launching the needle so that the needle is inserted into the urethra to allow the plurality of anchors and the ligature thread to be discharged through the needle.

The invention relates to the technical field of traditional Chinese medicine navel patches, and particularly discloses a patch formula for prostate treatment and a preparation process. The patch comprises rhizoma smilacis glabrae, flos carthami, rhizoma corydalis, plantain herb, herba patriniae, oxalis corniculata, oldenlandia diffusa, hibiscus mutabilis, borneol and menthol, and houttuynia cordata can also be added. The preparation method comprises the following steps: firstly, mixing part of medicinal materials, carrying out alcohol extraction twice, then carrying out water extraction, combining extracting solutions, and concentrating into extract; heating and melting the bionic polymerized gel, adding the extract, borneol and menthol, stirring, and finally coating on a base material for forming. The patch can be used for treating prostate diseases, and has the advantages that the transdermal delivery efficiency of active ingredients is high, the active ingredients can be effectively accumulated in prostate tissues, the anti-inflammatory effect is good, and the improvement rate of urinary tract symptoms can be increased; in addition, the preparation method has the advantages that active ingredients of the medicinal materials can be fully extracted, the process is stable, and industrial production is facilitated.

The invention discloses a combined medicine for treating chronic prostatitis and a preparation method thereof. Comprising the following active components in percentage by mass: 12%-18% of tanshinone IIA, 18%-22% of cortex phellodendri total alkaloids, 25%-30% of astragalus polysaccharide, 10%-15% of taraxacin, 8%-12% of ligustrazine, 4%-6% of spina date seed total saponins, 2%-4% of schizandrin and 1%-3% of glycyrrhizic acid. The tanshinone IIA, the amur corktree bark total alkaloids and the taraxacin in the combined medicine are used for inhibiting expression of inflammatory factors such as COX-2, TNF-alpha and IL-6, so that prostate tissue inflammatory response is directly blocked; meanwhile, the astragalus polysaccharide and glycyrrhizic acid cooperate to activate T lymphocyte subgroups, regulate Th1 / Th2 balance and enhance the immune defense capability of the body, so that the recurrence rate is reduced.