179results about How to "Less side effects" patented technology

The invention discloses a catechol side group-containing polylysine derivative as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) dissolving catechol acid in an organic phase, firstly adding NHS, stirring and dissolving until the materials are uniformly mixed, then adding EDC.HCl, and stirring and reacting to obtain a catechol-NHS intermediate solution; (2) dissolving polylysine or a salt thereof in a water phase, and adjusting the pH value to 6.0-7.0 by using an alkaline solution to obtain a solution of polylysine or a salt thereof; and (3) adding the intermediate solution obtained in the step (1) into the polylysine or the salt solution thereof obtained in the step (2), and maintaining the pH value of the reaction system at 5.0-6.0 by using an alkaline solution to obtain the catechol side group-containing polylysine derivative. The preparation method is short in reaction time and mild in reaction condition, and the obtained product is high in grafting rate and high in raw material conversion rate and has a good application prospect in the aspects of tissue adhesives and the like.

The invention relates to a uniform carbon-coated mesoporous silicon carbon negative electrode material and a preparation method and application thereof.The preparation method comprises the steps that a product obtained after pyrolysis and carbonization of a biomass carbon source is subjected to alkali activation treatment, acid pickling, drying, smashing, passivation, water washing and drying are conducted to obtain a mesoporous carbon matrix, nanometer silicon particles are deposited in pores of the mesoporous carbon matrix, and the uniform carbon-coated mesoporous silicon carbon negative electrode material is obtained. Then selecting a low-temperature carbonization material and polyethylene glycol to perform pre-carbonization and complete carbonization treatment on the mesoporous silicon carbon material to obtain a carbon coating layer, and finally obtaining the uniform carbon-coated mesoporous silicon carbon negative electrode material. When the uniform carbon-coated mesoporous silicon carbon negative electrode material is applied to a lithium battery, the mesoporous skeleton can effectively inhibit volume expansion of silicon in a battery circulation process, and the uniform carbon-coated layer can effectively reduce the risk of direct contact between the negative electrode material and an electrolyte, so that a stable SE I film is formed to reduce the occurrence of side reactions; and the first coulombic efficiency and the cycle performance of the battery are further improved.

The application provides a positive plate preparation method based on electrolyte moisture control and a battery. The core rule that "moisture of solid-state electrolyte wet powder is a key factor affecting the moisture of the positive plate" is first determined, and the long-standing error cognition in the industry that "controlling the total moisture of the slurry is enough" is corrected, providing a scientific theoretical basis for moisture control. By detecting three indexes before the slurry is used, the moisture of the positive plate can be accurately predicted whether it will exceed the standard, and the risk of scrapping the whole batch of positive plates is fundamentally avoided. By strictly controlling the moisture of the positive plate, the side reactions in the battery are effectively reduced, the capacity retention rate, rate performance and cycle life of the battery are improved, and the safety hazards such as swelling and thermal runaway caused by excessive moisture are reduced.

The invention discloses a method for preparing nitro-mesitylene through a micro-channel nitration reaction. The method comprises the following steps: respectively conveying mesitylene, fuming nitric acid and sulfuric acid to a micro-channel reaction module through a metering pump, and completing nitration reaction within a retention time of tens of seconds to several minutes. The introduction sequence of nitration reaction materials, the reaction retention time and the reaction temperature are cooperatively controlled, the nitration reaction is completed in the microchannel reactor in a continuous flow mode, operation is easy and convenient, safety is high, efficient continuous production can be achieved, meanwhile, emission of three wastes is reduced, and the industrial application advantages of being environmentally friendly and economical are achieved.

This invention belongs to the technical field of lithium battery anode materials, specifically relating to a highly conductive graphite electrode material and its preparation method. The preparation method includes: pre-dissolving sodium carboxymethyl cellulose into a gel solution, then ball-milling and mixing graphite and conductive carbon black, dispersing them together with a cobalt hexacyanorubium(II)-dodecyltungstencobalt(III) salt hybrid material and hafnium diboride nanomaterials in the gel solution, adjusting the acidity, adding styrene-butadiene rubber emulsion to obtain a uniform slurry, and then coating, drying, and compacting to obtain the anode sheet. This invention significantly improves the conductivity and structural stability of the graphite anode through the synergistic effect of the interface modification of the cobalt hexacyanorubium(II)-dodecyltungstencobalt(III) salt hybrid material and the conductive framework of the hafnium diboride nanomaterials. The process is safe and controllable, and suitable for industrial production of lithium-ion batteries.

The utility model relates to a chloroacetic acid production device for processing glycine, which is characterized in that an interlayer is arranged in the outer wall of a chlorination kettle, the side end is connected with a liquid level meter a, and a discharge pipe is arranged on the lower surface; a radar liquid level instrument, a chlorine feeding pipe, an on-line component analyzer, an on-line thermometer, an on-line hydrometer, a condensation pipe, a catalyst filling pipe and an acetic acid feeding pipe are sequentially arranged on the upper surface, the lower end of the chlorine feeding pipe is connected with a gas distributor, and the condensation pipe is externally connected with a condenser; the catalyst filling pipe is externally connected with a catalyst metering tank; a liquid level meter b is connected to the side end of the kettle body, a discharging pipe is arranged on the lower surface of the kettle body, a water supplementing pipeline is connected to the right side of the upper surface of the kettle body, a liquid inlet pipe and an online moisture measuring device are arranged on the left side of the upper surface of the kettle body, and the liquid inlet pipe is communicated with the discharging pipe; the upper end of the stirrer is connected with a stirring motor, and the lower end is connected with a frame-type stirring paddle; the utility model has the advantages of reasonable structural design and good use effect.

The invention discloses a process for preparing a V2O3 / ZnV2O3 total battery by simultaneously using vanadium oxide in a zinc ion battery as a positive electrode material and a negative electrode material, which comprises the following steps: reacting ammonium metavanadate with absolute ethyl alcohol by adopting a solvothermal synthesis method, washing, drying, and calcining in a tubular furnace to obtain V2O3; in the preparation process of the V2O3 positive electrode material, only V2O3, acetylene black serving as a conductive agent and PVDF serving as a binder are mixed in proportion and then are coated on graphite paper, other coating protection materials do not need to be introduced into a V2O3 / Zn negative electrode, and V2O3 is used as a protection layer to inhibit growth of zinc dendrites, relieve hydrogen evolution side reaction of the zinc negative electrode and reduce corrosion of zinc. Vanadium oxide V2O3 is directly used as a core positive electrode material, the zinc negative electrode coating is developed by utilizing the characteristics of the vanadium oxide V2O3, a material is formed, meanwhile, the performance optimization of the positive electrode and the negative electrode is realized, the used raw materials are simple and easy to obtain, the process is simple and easy to implement, and the preparation process is simple and easy to implement from V2O3 raw material synthesis to positive and negative electrode piece preparation to V2O3 / ZnV2O3 total battery assembly. And comprehensive improvement of positive and negative electrode performances of zinc ions is simultaneously realized by a single material.

The invention relates to the technical field of lithium ion batteries, in particular to a composite positive electrode material and a preparation method thereof, a lithium ion battery and electric equipment. The invention provides a preparation method of a composite positive electrode material, which comprises the following steps: mixing a bulk phase dopant, a lithium source and a ternary precursor to obtain a mixture I, and respectively sintering at 815-830 DEG C for 12-14 hours and at 760-770 DEG C for 8-10 hours to obtain a sintered material I-1 and a sintered material I-2; a first coating agent and a second coating agent are mixed with the sintered material I-1 and the sintered material I-2 respectively and then coated, and a sintered material II-1 and a sintered material II-2 are obtained; and mixing the sintered material II-1 and the sintered material II-2 to obtain the composite positive electrode material. According to the invention, the bulk phase dopant and the doped ternary precursor core layer are firstly added, then the first coating agent and the second coating agent are added, and the surface functional layer is synthesized, so that the composite positive electrode material has both high capacity and high cycle stability under the synergistic effect of the bulk phase dopant and the doped ternary precursor core layer.

This invention discloses a method for preparing the DPP1 inhibitor bresocarte, belonging to the field of pharmaceutical synthesis. Specifically, the method includes the following steps: N-tert-butoxycarbonyl-L-4-bromophenylalanine reacts with methanesulfonyl chloride or 4-nitrobenzenesulfonyl chloride in the presence of a base, followed by amination substitution to obtain intermediate 1; then, it undergoes dehydration in the presence of trifluoroacetic anhydride to obtain intermediate 2; next, it undergoes a coupling reaction with pinacol diboronate to obtain intermediate 3; then, it undergoes a coupling reaction with bromide compound 4 to obtain intermediate 5; then, it undergoes cyclization with di-tert-butyl dicarbonate in the presence of sodium methoxide to obtain intermediate 6; then, it undergoes deprotection in the presence of hydrogen chloride to obtain intermediate 7; next, it undergoes condensation with compound 8 to obtain intermediate 9; finally, it undergoes deprotection in the presence of hydrogen chloride to obtain the inhibitor bresocarte. This method provides a new synthetic approach, with low overall cost, simple operation, high yield, and suitability for industrial production.

The invention relates to the field of lithium ion batteries, and discloses a gel electrolyte, an in-situ curing electrolyte and a lithium ion battery. The gel electrolyte comprises a solvent, a polymer and a metal salt, wherein the polymer is a heterochain polymer with a main chain or a side chain containing a sulfur-containing siloxane group and a nitrogen-containing group. A main chain or a side chain of a polymer in the gel electrolyte contains a sulfur-containing siloxane group and a nitrogen-containing group, so that volatilization and leakage of a solvent can be inhibited, excellent liquid retention performance is brought, the thermal safety of a battery is improved, an interface side reaction can be inhibited, and the high-temperature and high-pressure stability of the battery is improved.

The application provides a preparation method of high-quality magnesium oxide and belongs to the technical field of magnesium metal oxide synthesis. The application uses magnesium hydroxide waste produced in an ethyl maltol process as raw material, and obtains magnesium oxide through sodium hypochlorite oxidation, twice water washing and calcination. The obtained magnesium oxide has high purity and high activity. The process flow of the application is short, the calcination temperature is low, the side reaction is less, the subsequent equipment investment is less, the price of sodium hypochlorite is relatively low, the cost is saved, new impurities are not introduced, and the application has good industrial application value.

The application provides a preparation method of 3,7-dinitro-1,3,5,7-tetraazabicyclononane, comprising the following steps: 1) feeding a first material comprising urea and concentrated sulfuric acid and a second material comprising fuming nitric acid and concentrated sulfuric acid into a microchannel reactor to perform a first-stage nitration reaction, to obtain a first-stage nitration reaction liquid; 2) feeding the first-stage nitration reaction liquid into a first tubular reactor to perform a second-stage nitration reaction, to obtain a second-stage nitration reaction liquid; 3) feeding the second-stage nitration reaction liquid and water into a second tubular reactor to perform a hydrolysis reaction, to obtain a hydrolysis liquid; 4) feeding the hydrolysis liquid and a third material comprising polyoxymethylene and ammonia water into a third tubular reactor to perform a condensation cyclization reaction, to obtain 3,7-dinitro-1,3,5,7-tetraazabicyclononane. The preparation method has the advantages of high safety, less waste pollution and simple operation.

The application discloses a preparation method of medium and long chain fatty acid triglyceride, and belongs to the technical field of oil deep processing. Firstly, plant oil and medium chain fatty acid triglyceride are used as substrates, a low eutectic solvent is used as a reaction medium, and an ester exchange reaction is carried out under the catalysis of immobilized lipase; after the reaction is completed, centrifugal treatment is carried out, and the low eutectic solvent, the immobilized lipase and the reaction product are recovered respectively; the recovered low eutectic solvent and the immobilized lipase are used for the next batch of reaction, and the recovered upper oil phase is the reaction product. The application uses immobilized lipase to catalyze ester exchange to prepare medium and long chain fatty acid triglyceride in a low eutectic system, the substrate conversion rate and the product generation amount are high, the product separation is easy, further separation and purification are not needed, the low eutectic solvent is green, environment-friendly and reusable, and the method has good ecological, economic benefits and industrialization application prospects.

This invention discloses a method for preparing pentaerythritol oleate based on sodium bisulfite. The method involves the esterification reaction of pentaerythritol and oleic acid with sodium bisulfite as an auxiliary agent. Sodium bisulfite, as an auxiliary agent, possesses both catalytic and antioxidant functions, effectively improving the reaction rate and product yield while suppressing oxidation side reactions. This eliminates the need for additional antioxidants, improving product quality and reducing costs. The preparation method is simple, mild, and environmentally friendly, with readily available raw materials, low-cost auxiliary agents, and easy separation. After the reaction, the catalyst is removed by hot filtration, and unreacted oleic acid is removed by solvent extraction, effectively reducing the product's acid value. The extracted potassium oleate byproduct has a purity of 80%–90% and can be used as a flotation agent, release agent, or raw material for lubricant production, making it suitable for industrial applications. The resulting pentaerythritol oil is suitable for high-end lubricants, bio-based plasticizers, and environmentally friendly coatings.

This invention relates to the field of battery technology, and more particularly to a positive electrode lithium replenisher, its preparation method, a positive electrode sheet, and a lithium battery. The aforementioned positive electrode lithium replenisher includes a core and a shell, with the shell covering the surface of the core to isolate the core from the side reaction environment. The core is a lithium-rich material, specifically at least one of Li5FeO4, Li5ReO6, and Li6CoO4. The shell is cobalt boride. This core-shell structured positive electrode lithium replenisher with cobalt boride as the shell effectively coats the core material, improves the air stability of the positive electrode lithium replenisher, reduces residual alkali, and thus enhances the battery's energy density and cycle performance.

The invention discloses a PEDV-S1 recombinant protein antigen as well as a preparation method and a vaccine thereof, and belongs to the technical field of recombinant protein vaccines. The CHO eukaryotic expression system is adopted, high expression and complete glycosylation modification of protein can be achieved, and therefore it is guaranteed that the vaccine has strong immunogenicity; through His tag fusion expression design, nickel column affinity chromatography is conveniently adopted for purification, the process is simple and convenient, and the protein recovery rate is also improved; in combination with a serum-free suspension culture technology, the method is suitable for large-scale production, and the stability among batches is good; the prepared vaccine is high in safety and few in side reaction; an immune challenge test further proves that the vaccine can induce a body to generate a high-level antibody and can effectively protect PEDV attack.

The invention provides high-molecular-weight low-viscosity polyether polyol and a preparation method and application thereof.The preparation method includes the step that mixed dihydric alcohol serves as an initiator and reacts with an epoxy compound under the action of a double-metal cyanide complex catalyst and an auxiliary acid, and the mixed dihydric alcohol contains propylene glycol and bifunctional polyether polyol. By adopting the technical scheme provided by the invention, the ultra-high molecular weight and low viscosity polyether polyol for the MS adhesive can be prepared.

The invention provides a lithium metal composite negative electrode, a preparation method thereof and a solid-state battery. The lithium metal composite negative electrode is of a multi-layer structure and sequentially comprises a current collector, a buffer binding layer, an active substance layer and an interface enhancement layer, the buffer binding layer is a conductive buffer material layer, the active substance layer is a lithium metal and / or lithium alloy layer, and the interface enhancement layer is a lithium metal and / or lithium alloy layer. The interface enhancement layer is a layer which contains an MOFs material, a lithium salt and an organic polymer material and has a three-dimensional porous structure. In the interface enhancement layer, an organic polymer material improves the surface mechanical strength of the negative electrode, improves the ionic conductivity and inhibits lithium metal expansion; the MOFs has a three-dimensional porous structure and can store a large number of lithium ions, accelerate ion conduction, regulate and control uniform deposition of metal lithium on the surface of the negative electrode and effectively inhibit growth of lithium dendrites on the surface of the negative electrode. The interface enhancement layer improves the compatibility between the lithium metal and the solid electrolyte, reduces the generation of side reactions, improves the cycle performance of the metal lithium solid-state battery and prolongs the service life of the metal lithium solid-state battery.

This invention belongs to the field of supercapacitor technology, specifically relating to a molybdenum oxide-molybdenum disulfide@polytannic acid electrode material, its preparation method, and its applications. Using molybdenum foil as the current collector and electrode, this invention prepares a molybdenum oxide-molybdenum disulfide electrode using electrochemical oxidation and hydrothermal methods. A polytannic acid coating is deposited on its surface to prepare a biodegradable molybdenum oxide-molybdenum disulfide@polytannic acid electrode. This electrode is then sandwiched with a biodegradable gel electrolyte and encapsulated with a biodegradable encapsulation material to construct a biodegradable supercapacitor with self-discharge suppression capabilities. By depositing a polytannic acid coating on the surface of the supercapacitor electrode, its self-discharge behavior is suppressed. The polytannic acid coating can prevent parasitic Faraday reactions of impurity ions on the electrode surface and prevent charge transfer, thereby suppressing the capacitor's self-discharge behavior. Simultaneously, the electrode, electrolyte, and encapsulation material can all degrade in simulated body fluids, potentially opening up applications in implantable medical electronic devices.

This application provides a method for preparing a positive electrode active material, the positive electrode active material, a battery, and a device, relating to the field of battery technology. The preparation method includes: mixing a positive electrode active material precursor with a lithium source to prepare a first mixture; mixing the first mixture with a phosphorus source to prepare a second mixture; and calcining the second mixture under an oxygen atmosphere to form a core in the first mixture, and reacting the phosphorus source with residual alkaline compounds on the surface of the core to form a coating layer, thereby obtaining the positive electrode active material. The positive electrode active material includes a core and a coating layer disposed on the surface of the core. The core includes a lithium-doped transition metal oxide, and the coating layer includes lithium phosphate. The embodiments of this application can reduce the content of residual alkaline compounds in the positive electrode active material, reduce side reactions between the positive electrode active material and the electrolyte, improve the ion conductivity of the positive electrode active material, and extend the cycle life of the battery.

The invention provides a negative electrode plate, a negative electrode plate preparation method and a battery, the negative electrode plate comprises a negative electrode active material layer, the negative electrode active material layer comprises a negative electrode active material and a modified binder, the negative electrode active material comprises a silicon carbon material and a polar coating, and the polar coating coats the silicon carbon material; the modified binder comprises a binder precursor, and an epoxy compound is grafted on the binder precursor. According to the negative plate provided by the invention, the silicon-carbon material is coated with the polar coating, the negative plate can be tightly attached to the silicon-carbon surface by utilizing polar interaction, the volume expansion of the silicon-carbon material is inhibited in the cyclic charging and discharging process, and meanwhile, the modified binder grafted with the epoxy compound can be used for inhibiting the volume expansion of the silicon-carbon material through the strong interaction among the epoxy compound, the silicon-carbon material and the polar coating. According to the present invention, the structure loosening caused by expansion is inhibited, and the flexibility of the binder is optimized, such that the binder can adapt to the expansion and shrinkage of silicon carbon, and the shedding of the active material and the side reaction of the electrolyte during the circulation process are reduced so as to effectively alleviate the capacity fading and improve the cycle life.

The application provides a reactor for producing phosphorus trifluoride, which comprises an automatic weighing and mixing unit and a reaction unit arranged in sequence. The reactor adopts one-step method to complete the reaction, and the process equipment is relatively simple and the production cost is low compared with the prior art. Furthermore, the device of the application adds molecular sieves for dehydration into dichloromethane, and the content of the molecular sieves is greater than the theoretical amount of the molecular sieves for dehydration of the dichloromethane, so that the side reaction caused by water can be greatly reduced, and the yield of the reaction is improved.

This invention provides a silicon-based anode composite material, its preparation method, and its application. The silicon-based anode composite material comprises a silicon-based core, a boronoxy lattice stabilizer, and an inert material. At least a portion of the boronoxy lattice stabilizer is embedded in the lattice structure of the silicon-based core, and the inert material coats the surface of the silicon-based core. This invention helps improve the initial coulombic efficiency and cycle performance of the silicon-based anode composite material.

This invention discloses a method for microwave-catalyzed dehydrogenation of naphtha to produce aromatics, specifically comprising the following steps: Step 1, oxidizing and etching the surfaces of four different diameter carbon fibers to obtain four modified carbon fibers; Step 2, preparing four platinum-carbon fibers of different diameters based on the four modified carbon fibers obtained in Step 1; Step 3, preparing a gradient-pore structured platinum-carbon fiber paper based on the four different diameter platinum-carbon fibers obtained in Step 2; Step 4, using the gradient-pore structured platinum-carbon fiber paper obtained in Step 3 to catalyze the dehydrogenation of naphtha to obtain aromatics. This invention uses microwave-assisted catalysis to lower the reaction temperature, achieving localized catalytic heating to reduce side reactions, and also achieves high dehydrogenation efficiency.

This application relates to a silicon anode battery and an electronic device. The silicon anode battery includes a positive electrode, a negative electrode, and an electrolyte. The negative electrode active material includes silicon, with a mass percentage of m% in the negative electrode active material layer. The positive electrode includes a positive current collector and a positive electrode active material layer disposed on at least one side of the positive current collector. The area of ​​the negative electrode active material layer is larger than that of the positive electrode active material layer, and the area difference between the two layers is a% of the area of ​​the negative electrode active material layer. The electrolyte contains additives, including silicon-based compounds, with a mass percentage of b% in the electrolyte. Wherein, 0.00002 ≤ b / (m×a) ≤ 3. The solution provided in this application can preferentially construct a stable interface layer in the inactive region of the electrode by synergistically controlling the electrolyte composition and key negative electrode material parameters, significantly suppressing side reactions and thus improving the battery cycle life.

The utility model discloses a fixed bed adiabatic reactor capable of automatically balancing internal temperature, and belongs to the technical field of fine chemical engineering. A fixed bed adiabatic reactor capable of automatically balancing the internal temperature comprises a reactor column body, the upper end and the lower end of the reactor column body are connected with a reactor upper sealing head and a reactor lower sealing head respectively, the fixed bed adiabatic reactor further comprises a sealing plate fixedly connected to the interior of the reactor upper sealing head, and a sealing cavity is formed between the sealing plate and the reactor upper sealing head; a plurality of groups of mounting holes are formed in the sealing plate; through the gasification and liquefaction exchange process of hydrogen sulfide in the heat exchange unit in the reactor, the temperature difference between the upper end and the lower end of the adiabatic reactor is reduced, and side reactions in the catalytic reaction process are reduced; meanwhile, heat at the bottom of the reactor is fully utilized to heat reactants at the top, and the preheating temperature of the feeding heat exchanger is effectively reduced, so that the reaction energy consumption is reduced, and the energy-saving and environment-friendly effects are achieved.

The application discloses a preparation method of low-chlorine high-purity bisphenol A type liquid epoxy resin. The method comprises the following steps: mixing raw materials containing epichlorohydrin, bisphenol A and a cosolvent, adding a catalyst A, and performing etherification reaction under low-temperature condition of not more than 50 DEG C; recovering unreacted epichlorohydrin in the system after the reaction is completed to obtain an etherification product; mixing the etherification product with a solvent, adding a catalyst B, and performing ring-closing reaction under low-temperature condition of not more than 50 DEG C; performing extraction separation on the obtained reaction product to obtain an organic phase; and performing desolventizing treatment on the organic phase to obtain the bisphenol A type liquid epoxy resin product. The total chlorine content of the obtained bisphenol A type liquid epoxy resin product is low, the viscosity is low, the purity is high, the quality is good, the preparation method is simple, the process flow is short, and the cost is low.

The application provides a preparation method of high-purity wild wheat, which comprises preparation of an acid agent ethyldi-n-propylamine and an intermediate di-n-propylamine thiocarbonate. Carbon oxysulfide gas is reacted with di-n-propylamine to generate di-n-propylamine thiocarbonate, and ethyldi-n-propylamine is used as a salt forming agent. 1,1,2,3-tetrachloropropene is condensed with the prepared di-n-propylamine thiocarbonate to generate wild wheat, and ethyldi-n-propylamine is used as an acid binding agent. The method discards the traditional process of using sodium hydroxide as an acid binding agent, reduces the decomposition of carbon oxysulfide, has less side reactions, and the content of the product can reach more than 99.5%.

This invention provides a low-dielectric photosensitive polyimide precursor, a photosensitive resin composition, its preparation method, and its application. The low-dielectric photosensitive polyimide precursor is prepared by reacting a polymer obtained from the reaction of a dianhydride monomer and a diamine monomer with organosilazane segments. It is a block polymer with alternating organosilazane and organosilane segments. This structure effectively reduces the dielectric constant of the material while ensuring high adhesion and high heat resistance. The silazane groups introduced in this invention can be converted into SiO2 structures at high temperatures, further reducing the dielectric constant of the polyimide matrix and enhancing its heat resistance. In addition, the silazane groups can react with hydroxyl groups on the substrate surface to generate silanol groups, thereby significantly improving the adhesion strength between the polyimide and the substrate.

The application provides a continuous preparation method of cyclohexylamine and belongs to the technical field of chemical reaction engineering. The method is that aniline is dissolved in a solvent a to obtain a substrate solution, the substrate solution is fully mixed with hydrogen in a fixed bed reactor provided with a catalyst through a flow meter, and reaction is carried out under temperature and pressure control; after the reaction is completed, the cyclohexylamine solution is obtained after temperature control and cooling, and then the solvent is removed under reduced pressure to obtain the cyclohexylamine. The method has the advantages of accurate feeding and controllable temperature, and has the advantages of mild reaction condition, low energy consumption, good strengthening mixing effect, few side reactions, high production efficiency, stable product quality, less tail gas pollution and green environmental protection.