269results about How to "Less side effects" patented technology

Provided is a substituted spiropyrido[1,2-a]pyrazine derivative or a pharmaceutically acceptable salt thereof, which is useful as an anti-HIV agent. The present invention relates to a compound represented by the following formula [I] or [II] or a pharmaceutically acceptable salt thereof:

wherein each symbol is as defined in the specification.

[Problem] Provided is a novel 1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine derivative or a pharmaceutically acceptable salt thereof, or a solvate thereof, which is useful as an anti-HIV agent.

[Solving Means] The present invention provides a compound represented by the following formula [I]

wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof.

The invention discloses a method for continuously preparing epoxy-propane, which is characterized in that a reactant containing propylene and hydrogen peroxide is continuously injected into a reaction system from a feed inlet, the raw powder form titanium silicate molecular sieve as a catalyst and the reactant are mixed uniformly to form slurry for reacting, the molecular sieve and the liquid reactant perform solid-liquid separation in a separation system, the molecular sieve is continuously circulated in a circulation pipeline composed of the reactor and the separation system, and part of liquid product flows out of the reaction system to obtain the objective product. By coupling the reaction and the separation in the method, the liquid product can be effectively discharged from the reaction region in time, the side reaction is reduced, the conversion rate of hydrogen peroxide is higher than 95% and the selectivity of the epoxypropane is higher than 90%.

A method for treatment of acne with tetracyclines is provided. A lower sustained dose and no loading dose is employed, with an optional once-a-day dosing regimen.

The invention discloses a catalyst for producing propylene by catalytic pyrolysis and a preparation method thereof. Calculated as the total weight of the catalyst, the catalyst comprises 20 to 40 weight percent of element-modified molecular sieve and 60 to 80 weight percent of heat-resistant inorganic oxide, wherein the content of a modified element is between 1 and 10 weight percent calculated as the total weight of the molecular sieve, the average grain diameter of crystal grains of the molecular sieve is between 10 and 100nm, and the modified element is one or a mixture of more of family IB metals and/or phosphorus. The catalyst is used for reactions that low carbon olefin, particularly the propylene is produced by C6-C12 olefins through catalytic pyrolysis, and has higher conversion rate of the C6-C12 olefins and yield of the propylene.

The invention belongs to the technical field of medicinal chemistry and discloses a preparation method of desmopressin acetate. The preparation method comprises the following steps of: synthesizing peptide resin of linear desmopressin by solid-phase synthesis, conducting cracking to obtain crude peptide of the linear desmopressin, then purifying the crude peptide of the linear desmopressin through reversed-phase high-performance liquid chromatography, afterwards carrying out liquid-phase oxidation, and finally conducting salt conversion to obtain the desmopressin acetate. Compared with the prior art, the preparation method integrates the advantages of solid-phase synthesis and liquid-phase oxidation, combines solid-phase synthesis, purification and liquid-phase oxidation, and is simple in operation, low in production cost and environmental pollution, high in yield of desmopressin acetate, and suitable for large-scale industrial production of desmopressin acetate. Besides, the desmopressin acetate product prepared by the method is fine in quality, high in purity and low in impurity content, therefore the method has a substantial economically practical value and wide application prospect.

The invention relates to the use of a combination of cannabinoids for the treatment of pain, inflammation and/or disease modification in arthritis. Preferably the cannabinoids are selected from cannabidiol (CBD) or cannabidivarin (CBDV) and delta-9-tetrahydrocannabinol (THC) or tetrahydrocannabinovarin (THCV). More preferably the cannabinoids are in a predefined ratio by weight of less than or equal to 19:1 of CBD or CBDV to THC or THCV.

The invention provides a phosphorus modified molecular sieve P-IM-5 for a toluene alkylation reaction, the content of phosphorus is 5-9 wt% measured as P2O5, the phosphorus modified molecular sieve P-IM-5 is used as a catalyst of active component. The molecular sieve P-IM-5 can minimize the auxiliary reaction in the toluene alkylation reaction and allow selectivity of xylene to reach to 100%, with high toluene conversion rate.

The invention discloses a preparation method of a large-sized perovskite structure CH3NH3PbI3 crystal. The method comprises the following steps: dissolving PbI2 into an HI (Hydrogen Iodide) solution, and preparing a Pb<2+>-HI solution; mixing the HI solution with a CH3NH2 solution in the molar ratio of 1:1, and reacting the mixture at the temperature of 0 DEG C for 2 hours to obtain a CH3NH2I solution; mixing the Pb<2+>-HI solution with the CH3NH2I solution, preheating at the temperature of 95 DEG C for 48-72 hours to obtain an oversaturated solution, and filtering the oversaturated solution to obtain a mother liquor for growing the CH3NH3PbI3 crystal, wherein the molar ratio of CH3NH2I to Pb<2+> is (1-2):1; and preheating the mother liquor in a water bath of 95.5-96 DEG C for 12-24 hours, placing the preheated mother liquor into a crystal growing container, performing programmed cooling to 45 DEG C, and keeping a constant temperature to obtain the CH3NH3PbI3 crystal. In a process of the method, the HI solution participates in the synthesis of raw materials, and is taken as a solvent of crystal growing, so that the method has the advantages of simple synthesizing process and small number of side reactions; and a growing device is simple, and a high-quality and large-sized crystal can be grown.

A system, method and apparatus are provided for treating dermatological conditions by generating a relatively large amount of thermal damage beneath a skin surface while generating relatively little thermal damage to the skin surface and/or epidermis. For example, the exemplary system, method and apparatus provide for directing a radiation beam onto a target location on the skin surface to thermally damage a volume of tissue beneath the target location, and directing a second radiation beam onto the same target location to thermally damage a different volume of tissue beneath the target location. The radiation beams may include ablative and/or non-ablative laser beams, or they may be generated by, e.g., a flashlamp, a tungsten lamp, a diode, or a diode array. The two beams may be pulsed. Further, they can be part of a single continuous wave beam, which can be rotated around an axis which passes through the target area, or which can be directed at a plurality of angles with respect to the skin surface.

The invention discloses a clean production process of 6-chloro-2,4-dinitroaniline. The clean production process of 6-chloro-2,4-dinitroaniline comprises the following steps: 1, dispersing 2,4-dinitroaniline into hydrochloric acid solution for pulping, then introducing chlorine gas into the solution for reacting, and thus obtaining intermediate reaction solution; and 2, adding the intermediate reaction solution obtained in the step 1 into sodium chlorate solution for reacting, after the reaction is completed, processing the reaction solution to obtain the 6-chloro-2,4-dinitroaniline and mother solution, and returning the mother solution to the step 1 to serve as the hydrochloric acid solution. According to the production process, the chlorine gas and the sodium chlorate are sequentially employed as chloride agents for chlorinating in steps, so that the product purity and yield are improved and the cost of material is reduced; and the quantity of hydrochloric acid after the reaction is completed is kept stable basically, so that the mother solution is convenient to recycle for use and the pollution to environment is reduced.

The invention relates to the field of gynecological medical apparatus and instruments, in particularly to an implant for uteruses. The implant for the uteruses comprises a membrane (1). The implant for the uteruses has the advantages that problems of irritation influence on uteruses due to existing implants implanted in uterine cavities for a long time, poor uterine mucous membrane repair effects of conventional medicine, influence on the whole bodies of patients due to hormone medicine for oral administration and the like can be solved by the aid of the medicine to a great extent, and effects and individual degrees can be greatly improved during phased utilization.

A treatment method for waste water with ammonia nitrogen is characterized in that the waste water is divided into two parts, part A and part B, wherein, magnesium salt precipitant is added to the waste water of part A and the pH value thereof is adjusted to 7.0-10.5; phosphoric acid precipitant is added to the waste water of part B and the pH value thereof is adjusted to 1-4.0; then the waste water of the two parts is mixed and the pH value of the mixed waste water is adjusted to 8-10; after sedimentation the sediment of magnesium ammonium phosphate and supernatant liquor with ammonia nitrogen removed are obtained. The method of the invention improves the utilization rate of the precipitant and has high ammonia nitrogen removal efficiency; the obtained MAP is easy to deposit and separate and the turbidity is dramatically reduced, thereby reducing the difficulty of following flocculation treatment with short reaction sedimentation.

The process of producing aromatic carboxylic acid with diamine compound as catalyst additive includes 1. obtaining aromatic carboxylic acid product directly in aliphatic carboxylic acid as solvent with gaseous alkyl arene oxide containing oxygen molecule or its partially oxidized intermediate product; and 2. adopting high efficiency quaternary composite Co-Mn-Br-diamine catalyst system. The diamine catalyst activator includes diamino hydrocarbon derivative, aliphatic diamine compound, aromatic diamine compound and ammonium salt of diamine compound. The quaternary composite Co-Mn-Br-diamine catalyst system has Co/Mn molar ratio of 0.1-100, Br/(Co+Mn) molar ratio of 0.1-10 and Co concentration in 50-10,000 ppm of solvent weight. The present invention has accelerated oxidation course, lowered combustion side reaction, less impurity, less corrosion to the apparatus and lowered power consumption and material consumption.

The invention discloses a method for extracting vitamin E and phytosterin from cottonseed oil deodorizer distillate, comprising the following steps that: methanol is added by taking cottonseed oil deodorizer distillate as raw material, reaction is proceeded by taking strong-acid cation exchange resin as catalyst so that free fatty acid in the raw material is converted into relative methyl ester; the catalyst is filtered; the filtrate is evaporated and is then formulated into mixed solution with ethanol after methanol and water are removed, after the mixed solution passes through an adsorptioncolumn filled with adsorbent, bed is washed with ethanol until the effluent solution is transparent and clear, and the effluent solution is collected; the adsorption column is eluted with acetic acidethanol solution, the eluant is collected and then subjected to reduced pressure evaporation, and vitamin E is acquired after the solvent is removed; the material of the effluent solution in which ethanol is removed by evaporation is dissolved in methanol, crystals are separated subsequent to temperature reduction and standing under stirring, and phytosterin crystals are acquired by filtering separation. The invention simplifies the steps for reaction and has the characteristics of small corrosiveness to equipment, no environmental pollution, simple operation and less equipment investment.

The invention discloses a preparation method of a modified cathode material of a lithium ion battery and a battery applying the same. The invention is mainly characterized by taking lithium metal oxide which can be represented by using the general formula LiAl-xBxO2 of a molecular formula and has a laminar structure as a matrix of the modified cathode material. The surface of the matrix of the cathode material is coated with a layer of porous organic polymer for modification, and the organic polymer is a copolymer of vinylidene fluoride and hexafluoropropylene, or/and a homopolymer or a copolymer of ethylene oxide and propylene oxide. The modified cathode material in the lithium ion battery generates a reaction with a solvent in electrolyte or under the action of an additive to form a gelatinous dielectric layer. The modified cathode material is suitable for various lithium ion batteries and is especially suitable for polymer type lithium ion batteries.

The invention discloses a colorless and transparent epoxy function group-containing silicone resin preparation method. The method comprises the following steps: adding a catalyst solution into a reaction bottle provided with alkoxy silane, an end capping reagent and a solvent in a dropwise manner, polycondensing, extracting to obtain a silicone resin solution, reacting the silicone resin solution with epoxy alkyl siloxane under the action of a catalyst at 80-150DEG C for 2-6h, neutralizing, filtering, washing with water, and distilling to prepare an epoxy function group-containing silicone resin. The silicone resin prepared through the method is colorless and transparent, has an epoxy value of 0.1-0.5, and has an excellent caking property with a PPA base material.

The invention discloses a high-nickel positive electrode material for a non-aqueous electrolyte secondary battery and a preparation method for the high-nickel positive electrode material. The high-nickel positive electrode material is represented by a general formula: Li<w>Ni<1-x-y>Co<x>Mn<y>M<z>O<2>, wherein an average particle diameter D50 is 8-15 [mu]m, and is formed by the small particle sizeD50 of 2-5 [mu]m and the small particle size D50 of 8-18 [mu]m, the Co content (metal molar ratio, SC) of the small particle diameter is higher than the Co content (metal molar ratio, LC) of the largeparticle diameter, and the Co concentration ratio (SC/LC) is preferably from the range of 1.2-2. According to the invention, the material structure of the high-nickel positive electrode material is stabilized through element doping and coating, and the crystal structure of the material is stabilized by increasing the cobalt content in the small particle size, and the cycle performance of the material is improved; and finally, the small particle size and the large particle size are mixed according to different proportions, so that the tap density of the positive electrode material and the compaction density of a pole piece are improved.

The invention discloses a nanometer silicon-carbon composite material and a preparation process thereof, and an application of the nanometer silicon-carbon composite material as a negative electrode material in a lithium ion battery. The nano-silicon-carbon composite material has a multi-stage structure, wherein the nano-silicon particles are taken as a core, the amorphous carbon is taken as an intermediate cladding layer, and the carbon fluoride is taken as a shell. The above preparation proces, Nano-silicon was prepared by simple alloying and de-alloying of low-cost crude silicon and magnesium powder. In the process of de-alloying, magnesium silicide and polymer pyrolysis were used simultaneously, and nano-silicon-carbon and carbon fluoride were combined by physical ball milling to prepare nano-silicon-carbon composite. The SiC nanocomposites prepared by the above method have high capacity, high first Coulomb efficiency and excellent cycle performance. The method has the advantages of simple process, low energy consumption, and is favorable for industrial production.

The invention discloses a method for forming an amination catalyst. At first, a forming formula of the amination catalyst comprises 60%-90% of component A, 5%-35% of component B and 5% of component C, wherein the component A is molecular sieve based catalyst powder, and the molecular sieve based catalyst powder A is prepared by the following method: H-ZSM-5 is added into 0.1mole/liter hydrochloric acid solution to be subjected to heating reflux for 2 hours, wherein the solid-liquid volume ratio of the H-ZSM-5 to the hydrochloric acid solution is 1:4, after filtering, cleaning and drying are performed, dealuminized H-ZSM-5 is obtained, and the molar ratio of SiO2 to Al2O3 is 150-350; the component B is a phosphorous acid or hypophosphorous acid compound; and the component C is sesbania cannabina Pers or methyl cellulose. The components A, B and C are mixed uniformly according to the forming formula, the mixture is granulated, tabletted or extruded and is calcinated for 6 hours at 530 DEG C, so that a formed amination catalyst finished product is obtained.

The invention provides a load-type phosphotungstic acid catalyst. The catalyst comprises a hollow-sphere mesoporous silica carrier and phosphotungstic acid loaded on the hollow-sphere mesoporous silica carrier. When the total weight of the catalyst is taken as a reference, the content of the phosphotungstic acid is 5-50 wt%, and the content of the hollow-sphere mesoporous silica carrier is 50-95 wt%. The invention further provides a preparation method of the load-type phosphotungstic acid catalyst and an n-butyl acrylate preparation method with the load-type phosphotungstic acid catalyst. The load-type phosphotungstic acid catalyst provided by the invention can be repeatedly used through recovery, has better catalytic performance compared with that of a homogeneous catalyst, namely concentrated sulfuric acid, and does not erode equipment.

The invention relates to cross-linked sodium hyaluronate and a preparation method and application thereof. The cross-linked sodium hyaluronate is prepared from raw materials, including sodium hyaluronate, an inorganic salt and a cross-linking agent. The preparation method comprises the steps: dissolving a certain amount of sodium hyaluronate in an alkaline solution with the pH value of 7.5 to 9.0, then, adding a certain amount of inorganic salt into the solution, and carrying out stirring until the inorganic salt is completely dissolved; heating the solution to the temperature of 20 DEG C to 60 DEG C, then, slowly dripping a certain volume of cross-linking agent solution into the solution, carrying out stirring, and carrying out a reaction for a period of time while carrying out heat preservation; adjusting the pH to 7.1 to 7.5 with acid, carrying out balancing for 1 to 2 hours, then, carrying out precipitation with ethanol or an ethanol solution, so as to obtain lumpy solids, i.e., the cross-linked sodium hyaluronate. By the method provided by the invention, the cross-linking efficiency of the cross-linked sodium hyaluronate can be increased, the reaction yield can be increased, side reactions can be reduced, and the residual of the cross-linking agent can be reduced; the prepared cross-linked sodium hyaluronate is safe and non-toxic, is good in stability, long in in-vivo retention time and good in filling effect and is applicable to in-vivo injection.

The invention provides a method for synthesizing and purifying irinotecan. The method prepares irinotecan that is an antineoplastic compound with high purity quotient through the purification of 7-ethide-10-hydroxycamptothecine that is an intermediate for synthesizing irinotecan and crystallization for impurity removal of hydrochloric piperidyl piperidine formyl chloride; secondary reaction is reduced, and the purity quotient as well as the yield of products are increased through improving the reaction condition at the same time, especially through cryoconcentration evolution; the purity quotient of the obtained products is more than 99.5 percent, and the single hetero is less than 0.1 percent. In addition, the method overcomes the disadvantages that the cycle is long, the solvent quantity is large, etc. caused by column chromatography that is used for purifying the products, and large scale production is easy to realize.

The invention discloses a multi-level cooperative modified lithium battery positive electrode material nickel-cobalt lithium manganate and a preparation method thereof. The prepared lithium battery positive electrode material nickel-cobalt lithium manganate is composed of lithium transition metal composite oxide particles which are expressed by a general formula LiaMn1-x-y-zNixCoyM1zM2wO2-(M3tOmt/2), M1 elements are mainly distributed in primary particles of the material, M2 elements mainly exist on the surfaces of the primary particles, and M3 elements mainly exist on the surfaces of secondary particles of the material. According to the method, multi-level modification on the surfaces of the secondary particles, the surfaces of the primary particles and the interiors of the primary particles of the material can be achieved, the prepared material has good storage, output and circulation characteristics, and the application requirement of lithium-ion batteries, in particular to power batteries for vehicles is met.

The embodiment of the invention relates to a method for reducing the content of residual alkali on the surface of a high-nickel positive electrode material of a lithium ion battery. The method comprises the following steps: adding a certain amount of acid or a derivative of the acid into a certain amount of non-aqueous inactive hydrogen organic solvent at a stirring speed of 1m/s to 10m/s at normal temperature, and stirring until the acid or the derivative of the acid is completely dissolved, so as to obtain a washing solution for reducing residual alkali on the surface of the high-nickel positive electrode material of the lithium ion battery; wherein the mass ratio of the to-be-treated high-nickel positive electrode material to the non-aqueous non-active hydrogen organic solvent is 1:0.5-1:4; wherein the molar concentration of the acid or the derivative of the acid in the washing liquid is 0.5-1.5 times of the molar weight of the residual alkali on the surface of the to-be-treated high-nickel positive electrode material; adding a to-be-treated high-nickel positive electrode material into the washing liquid while stirring at a linear speed of 1m/s to 10m/s, and stirring for 1 to 120 minutes; and centrifuging to remove the solvent, vacuumizing, heating and drying at 20-80 DEG C to obtain the treated high-nickel positive electrode material.

The invention discloses a method for synthesizing a biodegradable aliphatic-aromatic copolyester. The method comprises the following steps: performing continuous esterification on aromatic dicarboxylic acid and aliphatic dicarboxylic acid, adding epoxidized soybean oil, performing continuous prepolycondensation, grafting an epoxy ester into a polyterephthalic acid-adipic acid butanediol PBAT molecular chain in the prepolycondensation process, and performing continuous polycondensation under a condition of a higher temperature, so as to enable the molecular weight and the specific viscosity totarget values. By adopting the method for synthesizing the biodegradable aliphatic-aromatic copolyester, the polyester can easily meet target specific viscosities and molecular weights, the polycondensation time of a high-temperature high-viscosity material can be shortened, side reactions can be reduced, the carboxyl value of a product end can be reduced, and the problem of resin yellowing can besolved. By adopting the method for synthesizing the biodegradable aliphatic-aromatic copolyester, chain extension is implemented without a micromolecule chain extender, so that the problem that a residual chain extender is migrated to a food from a plastic can be solved.

A LiNixCo1-x-yMnyO2 cathode material coated with boron-lithium composite oxide is a LiNixCo1-x-yMnyO2 cathode material with its surface coated with a layer of boron-lithium composite oxide. A preparation method of the material comprises the following steps: adding prepared LiNixCo1-x-yMnyO2 into a mixed alcoholic solution of a lithium source and a boron source, uniformly dispersing LiNixCo1-x-yMnyO2 in the solution by ultrasonic treatment, adding a dispersant, fully immersing the material in the solution, evaporating a solvent and carrying out heat treatment so as to obtain alpha-Li4B2O5-coated LiNixCo1-x-yMnyO2. Contact between a coating and the cathode material at the molecular level is realized, and thickness of the coating layer is uniform. In addition, by coating the surface of the cathode material with the boron-lithium composite oxide, diffusion coefficient of lithium ion is raised, and ionic conductivity of the material is enhanced. Meanwhile, direct contact between an electrolyte and the cathode material is avoided effectively, and side effect of electrodes is minimized. Thus, chemical stability and cycle performance of the cathode material are improved.

The invention discloses a Raney nickel catalytic preparation method of 2,2'-bipyridine and belongs to the technical field of organic synthesis. The method comprises the following steps: pretreating raw materials to make purity of pyridine reach 99.8 wt% and above, carrying out dehydrogenation activation on a Raney nickel catalyst, and carrying out catalytic dehydrogenation coupled reaction, extraction separation and distillation purification so as to obtain 2,2'-bipyridine. Purity content is below 3 wt%. By reasonably combining soxhlet extraction principle and fluidized-bed process, timely separation of the product and the catalyst can be effectively guaranteed, service life of the catalyst is prolonged, side reaction can be reduced, and product purity is ensured. The method is clean and environmentally friendly. All solvents, including pyridine which hasn't participated in the reaction, can be recycled. The method is pollution-free to the environment. Waste of raw materials is avoided. The method has remarkably economic and social benefits.

The invention provides a method for preparing penam sulfoxide acid diphenyl methyl ester. The method includes steps of carrying out bromination reaction on 6-aminopenicillanic acid to obtain first reaction products; carrying out reaction on the first reaction products and diphenyl-chloromethane under the effects of phase transfer catalysts to obtain second reaction products, adding hydrogen peroxide into the second reaction products, carrying out oxidation reaction on the hydrogen peroxide and the second reaction products to obtain third reaction products and centrifugally washing the third reaction products to obtain 6-bromine penicillin sulfoxide acid diphenyl methyl ester; carrying out further reaction on the 6-bromine penicillin sulfoxide acid diphenyl methyl ester to obtain the penam sulfoxide acid diphenyl methyl ester. The method has the advantages that dichloromethane and water are used as solvents in the bromination reaction, accordingly, side reaction in the bromination reaction can be reduced, and emission of organic matters in wastewater can be reduced; ester with a high yield can be obtained from diphenyl mecloqualone by the aid of the phase transfer catalysts, the cost can be saved as compared with other processes by the aid of diphenyl carbinol used as a raw material and DCC (dicyclohexylcarbodiimide) used as a catalyst and processes by the aid of benzophenone hydrazone and catalysts which comprise explosive peracetic acid and added potassium iodide, and processes for preparing the penam sulfoxide acid diphenyl methyl ester are green and safe.

The invention relates to a spherical illite mesoporous composite material, a preparation method thereof, the spherical illite mesoporous composite material prepared by the preparation method, a supported catalyst containing the spherical illite mesoporous composite material, a preparation method of the supported catalyst, the supported catalyst prepared by the preparation method, application of the supported catalyst in ketalization reaction, and a preparation method of cyclohexanone glyceryl ketal by use of the supported catalyst. The spherical illite mesoporous composite material contains illite, a mesoporous molecular sieve material with a one-dimensional hexagonal-channel distribution structure and a mesoporous molecular sieve material with a two-dimensional hexagonal-channel distribution structure. The supported catalyst prepared from the illite mesoporous composite material as a carrier can significantly increase the conversion rate of reaction raw materials in the ketalization reaction process.