Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor

Inactive Publication Date: 2005-03-10
JAPAN TOBACCO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some of these pharmaceutical agents are known to HIV cause side effects such as liver function failure, central nervous disorders (e.g., vertigo), and th

Method used

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  • Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
  • Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
  • Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Example

Example 1

Synthesis of 2-(3,4-dichlorobenzyl)-9-hydroxy-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione hydrochloride

Step 1

To a solution of 3-benzyloxy-4-oxo-4H-pyran-2-carboxylic acid (0.4 g) prepared according to the method described in references (JP-A-2-502281 (WO88 / 06588), J. Med. Chem., 1999, 42, 4814-4823) in chloroform (30 ml) were added oxalyl chloride (0.21 ml) and dimethylformamide (0.01 ml), and the mixture was stirred at room temperature for 30 min. The reaction solvent was evaporated under reduced pressure, toluene was added, the mixture was concentrated and dissolved in chloroform (5 ml). 3,4-Dichlorobenzylamine (0.23 ml) and triethylamine (0.34 ml) were added successively under ice-cooling, and the mixture was stirred under ice-cooling for 20 min. 5% Aqueous potassium hydrogen sulfate solution was added to the obtained reaction mixture and the mixture was extracted with chloroform. The organic layer was washed with saturated brine and dried over sodium sulfate. Th...

Example

Example 2

Synthesis of 2-(3,4-dichlorobenzyl)-10-hydroxy-2,3,4,5-tetrahydropyrido[1,2-a][1,4]diazepine-1,9-dione

Step 1

N-(3,4-Dichlorobenzyl)-3-benzyloxy-4-oxo-4H-pyran-2-carboxamide (60 mg) obtained in the same manner as in Example 1, step 1 was dissolved in tetrahydrofuran (0.5 ml), ethanol (0.5 ml) and water (0.1 ml), and 3-amino-1-propanol (0.0226 ml) and sodium carbonate (8 mg) were successively added. The mixture was stirred at room temperature for 7 hr. The solvent was evaporated, and the obtained residue was purified by silica gel column chromatography (ethyl acetate:methanol=100:0-4:1) to give N-(3,4-dichlorobenzyl)-3-benzyloxy-1-(3-hydroxypropyl)-4-oxo-1,4-dihydropyridine-2-carboxamide (43 mg).

1H-NMR(DMSO-d6)δ 9.47(t,1H,J=6.0 Hz), 7.65(d,1H,J=7.4 Hz), 7.57(d,1H,J=1.9 Hz), 7.34-7.25(m,7H), 6.26(d,1H,J=7.4 Hz), 5.05(s,2H), 4.65(t,1H,J=4.9 Hz), 4.42(d,2H,J=6.0 Hz), 3.86(dd,2H,J=7.2,7.2 Hz), 3.35(dd,2H,J=6.3,10.9 Hz), 1.84-1.77(m,2H).

Step 2

N-(3,4-Dichlorobenzyl)-3-benz...

Example

Example 3

Synthesis of 2-(3,4-dichlorobenzyl)-9-hydroxy-3-methyl-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

N-(3,4-Dichlorobenzyl)-3-benzyloxy-4-oxo-4H-pyran-2-carboxamide (50 mg) obtained in the same manner as in Example 1, Step 1 was dissolved in tetrahydrofuran (0.5 ml), ethanol (0.5 ml) and water (0.1 ml). DL-1-Amino-2-propanol (0.0191 ml) and sodium carbonate (7 mg) were successively added, and the mixture was stirred overnight at room temperature. The solvent was evaporated, and the obtained residue was purified by silica gel column chromatography (ethyl acetate:methanol=100:0-4:1) to give N-(3,4-dichlorobenzyl)-3-benzyloxy-1-(2-hydroxypropyl)-4-oxo-1,4-dihydropyridine-2-carboxamide (34 mg).

1H-NMR(DMSO-d6)δ 9.43(t,1H,J=6.3 Hz), 7.57(s,1H), 7.57(d,1H,J=7.4 Hz), 7.36(d,1H,J=8.1 Hz), 7.31-7.26(m,6H), 6.23(d,1H,J=7.4 Hz), 5.08(d,1H,J=10.9 Hz), 5.04(d,1H,J=10.9 Hz), 5.02(d,1H,J=6.3 Hz), 4.44(dd,1H,J=6.3,14.8 Hz), 4.37(dd,1H, J=6.3,14.8 Hz), 3.81(brs,1H), 3.69(dd,1H,J=3.7,14.4...

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Abstract

The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I]
wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, and an anti-HIV agent containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an agent for the prophylaxis or treatment of AIDS, or as an anti-HIV agent. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agent. Becuae it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.

Description

TECHNICAL FIELD The present invention relates to a novel nitrogen-containing fused ring compound or a pharmaceutically acceptable salt thereof useful as an anti-HIV agent. Moreover, the present invention relates to novel use of a certain kind of nitrogen-containing fused ring compound or a pharmaceutically acceptable salt thereof as an anti-HIV agent. More specifically, the present invention relates to an anti-HIV agent containing a nitrogen-containing fused ring compound or a pharmaceutically acceptable salt thereof showing an anti-HIV action particularly based on an integrase inhibitory activity. BACKGROUND ART HIV (Human Immunodeficiency Virus (type 1)) belonging to retrovirus is a causative virus of AIDS (Acquired Immunodeficiency Syndrome). HIV targets CD4 positive cell groups such as helper T cell, macrophage and dendritic cell and destroys these immunocompetent cells to cause immunodeficiency. Accordingly, a pharmaceutical agent that eradicates HIV in a living organism or...

Claims

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Application Information

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IPC IPC(8): A61K31/4985A61K31/519A61K31/53A61K31/551A61P31/12A61P31/18A61P43/00C07D471/04C07D487/04
CPCC07D487/04C07D471/04A61P31/00A61P31/12A61P31/18A61P43/00
Inventor MIYAZAKI, SUSUMUKATOH, SUSUMUADACHI, KAORUISOSHIMA, HIROTAKAKOBAYASHI, SATORUMATSUZAKI, YUJIWATANABE, WATARUYAMATAKA, KAZUNOBUKIYONARI, SHINICHIWAMAKI, SHUICHI
Owner JAPAN TOBACCO INC
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