The application describes an
assay for the identification of
small molecule modulators of
integrin CD11b / CD18 and small molecules capable of modulating activity of this
receptor. For example, one such compound useful as an
agonist of
integrin CD11b / CD18 is the compound of Formula (I):Such compounds may be used in certain embodiments for treating a
disease or condition selected from
inflammation, immune-related disorders,
cancer,
ischemia-
reperfusion injury,
stroke, neointimal thickening associated with vascular injury, bullous pemphigoid, neonatal obstructive
nephropathy, and cardiovascular
disease, or in other embodiments for the treatment of a
disease or condition selected from immune deficiency, acquired
immune deficiency syndrome (AIDS),
myeloperoxidase deficiency, Wiskott-Aldrich syndrome, chronic granulomatous disease, hyper-IgM syndromes, leukocyte adhesion deficiency, Chediak-Higashi syndrome, and severe combined
immunodeficiency.