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4 results about "Myeloperoxidase" patented technology
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Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation. Neutrophil myeloperoxidase has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus. The green color contributed to its outdated name verdoperoxidase.
Pyrrolo[3,2-d]pyrimidin-4-one derivative, and preparation method therefor and medical use thereof
A compound of formula (I), and a preparation method therefor and a use thereof in medicine. Specifically, the present invention provides a compound of formula (I) or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, and also relates to a pharmaceutical composition containing the compound and a use of the compound in the preparation of a drug for treating and / or preventing cardiovascular diseases. The compound is an inhibitor for myeloperoxidase (MPO).
![Pyrrolo[3,2-d]pyrimidin-4-one derivative, and preparation method therefor and medical use thereof](https://images-eureka.patsnap.com/patent_img/1a9ce614-cdba-4203-aab5-6bf18fc82606/US20260200929A1-D00001.png "Pyrrolo[3,2-d]pyrimidin-4-one derivative, and preparation method therefor and medical use thereof")
![Pyrrolo[3,2-d]pyrimidin-4-one derivative, and preparation method therefor and medical use thereof](https://images-eureka.patsnap.com/patent_img/1a9ce614-cdba-4203-aab5-6bf18fc82606/US20260200929A1-C00001.png "Pyrrolo[3,2-d]pyrimidin-4-one derivative, and preparation method therefor and medical use thereof")
![Pyrrolo[3,2-d]pyrimidin-4-one derivative, and preparation method therefor and medical use thereof](https://images-eureka.patsnap.com/patent_img/1a9ce614-cdba-4203-aab5-6bf18fc82606/US20260200929A1-C00002.png "Pyrrolo[3,2-d]pyrimidin-4-one derivative, and preparation method therefor and medical use thereof")
Owner:SHENZHEN SALUBRIS PHARMA CO LTD
A pyrazole compound, a preparation method and use thereof
The application belongs to the technical field of chemical drugs, and particularly relates to a pyrazole compound and a preparation method and application thereof. The application provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, which not only has good myeloperoxidase (MPO) inhibitory activity, but also can be used for treating and / or preventing cardiovascular diseases. (I)
Owner:LEPING KANG XIN MEDICINE CHEM CO LTD
A sulfur-containing 5-aminosalicylic acid prodrug and its uses
ActiveCN117567337BInhibitionInhibition of secretionOrganic active ingredientsOrganic chemistryPeroxidaseSulfanilamide
This invention discloses a sulfur-containing 5-aminosalicylic acid prodrug and its uses, belonging to the field of biomedical technology. The sulfur-containing 5-aminosalicylic acid prodrug of this invention has the structure shown in general formula I. This type of compound has good intervention effects on inflammation-related diseases, exhibiting more ideal anti-inflammatory activity than 5-ASA and sulfasalazine. It can also inhibit the production of hypochlorous acid and related inflammatory mediators by inhibiting myeloperoxidase (MPO), and can be used to prepare drugs for the prevention and / or treatment of inflammatory bowel disease, and drugs for the prevention and / or treatment of diseases related to abnormal oxidative stress.
Owner:CHINA PHARM UNIV
A myeloperoxidase-responsive fluorescent probe liposome and a preparation method and application thereof
This invention discloses a myeloperoxidase-responsive fluorescent probe liposome, its preparation method, and its applications. The raw materials for this fluorescent probe liposome include lecithin, cholesterol, collagen, luminol, and Cy5. These raw materials are prepared using a thin-film dispersion method to obtain the fluorescent probe liposome. This invention combines luminol with Cy5, solving the problem of low sensitivity or even undetectability of luminol to deep inflammatory foci in body tissues. It enables imaging detection of deep inflammatory cells in the body, which has significant application value in evaluating inflammatory responses caused by tumors, epilepsy, etc., and is of great significance for guiding clinical treatment of tumors and epilepsy and assessing efficacy.
Owner:CHINA WEST NORMAL UNIVERSITY