The invention belongs to the technical field of
medical biology, and particularly relates to an application of an
induction method for improving the capacity of mesenchymal stem cells in promoting acute
myeloid leukemia cell differentiation. The mesenchymal stem cells provided by the invention are human-derived
umbilical cord mesenchymal stem cells (UC-MSCs), and mesenchymal stem cells (pre-activeMSCs) obtained after pretreatment and activation by
cytokine bone morphogenetic protein 6 (BMP6); the pre-active MSCs can efficiently induce the acute
myeloid leukemia cell differentiation, and the capacity is achieved by changing the expression quantity of IL-6 and IDO of the UC-MSCs; and the mesenchymal stem cells are allogeneic mesenchymal stem cells, the
secretion capacity of the mesenchymalstem cells can be remarkably changed after the mesenchymal stem cells are treated and activated by the BMP6, and the AML resistance of the mesenchymal stem cells is remarkably enhanced. Compared withchemotherapy,
mesenchymal stem cell transplantation has lower toxic and side effects, has low
immunogenicity and meets clinical requirements. According to the method, the capacity of the MSCs in inducing the acute myelogenous
leukemia cell differentiation is improved by adopting the method of pretreating and activating the MSCs through the BMP6, and the method can be applied to differentiation treatment of acute myelogenous
leukemia.