New application of gamma-secretase activated protein gene and/or protein coded by gamma-secretase activated protein gene

A technology for activating proteins and secretases, which is applied in the field of biomedicine, and can solve the problems that molecular targeted drugs are difficult to meet clinical treatment, complex pathogenesis, and insufficient research.

Active Publication Date: 2021-05-25
SHANDONG UNIV QILU HOSPITAL
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

The pathogenesis of AML is complicated and the clinical prognosis is poor. Although combined chemotherapy can achieve complete remission (CR) in most patients, only a few special types of AML patients can survive for a long time, and most patients develop disease within 3 years after CR. Relapse, and refractory or relapsed patients have poor chemotherapy effect, so individualized treatment targeting key molecules in the occurrence and development of AML will become the develo

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  • New application of gamma-secretase activated protein gene and/or protein coded by gamma-secretase activated protein gene
  • New application of gamma-secretase activated protein gene and/or protein coded by gamma-secretase activated protein gene
  • New application of gamma-secretase activated protein gene and/or protein coded by gamma-secretase activated protein gene

Examples

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Embodiment 1

[0020] Example 1 Screening and verification of acute myeloid leukemia prognostic marker molecule GSAP

[0021] 1. Materials and methods

[0022] 1 Bioinformatics data analysis tools

[0023] 1.1 Cancer and Tumor Gene Atlas (The Cancer Genome Atlas, TCGA)

[0024] The TCGA project is invested by the U.S. government. It aims to use genome sequencing technology to map all human cancer genome variations and conduct comparative analysis to study the relationship between RNA and protein expression, DNA copy number changes, and patient prognosis. . So far, more than 30 kinds of human tumor data have been included in the TCGA database, which is of great significance for the diagnosis and treatment of tumors including AML.

[0025] 1.2 Gene Expression Omnibus (GEO) database

[0026] GEO is an international public database containing high-throughput gene expression and other functional genomics data. It is supported and maintained by the National Center for Biotechnology Information...

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Abstract

The invention relates to a novel application of gamma-secretase activated protein gene and/or protein coded by gamma-secretase activated protein gene. According to the application disclosed by the invention, by screening acute myelogenous leukemia (AML) prognosis related molecular markers, the screened gamma-secretase activated protein gene (GSAP) is closely related to the prognosis of acute myelogenous leukemia patients; the high expression of the GSAP prompts that the prognosis of the acute myelogenous leukemia patient is poor; the GSAP is related to FAB typing and cytogenetics risk stratification of an acute myelogenous leukemia patient; and the GSAP may participate in the disease progress of acute myelogenous leukemia through various ways such as PI3K-AKT, TLR and the like. The GSAP is used for preparing a treatment drug or a diagnostic reagent and a prognosis detection reagent for acute myelogenous leukemia.

Description

technical field [0001] The invention belongs to the field of biomedicine, in particular to the new application of gamma-secretase activating protein gene and / or its encoded protein. Background technique [0002] Acute myeloid leukemia (AML) is a malignant clonal disease originating from hematopoietic stem / progenitor cells, which is mainly characterized by uncontrolled proliferation, apoptosis arrest, and differentiation arrest of myeloid primitive and immature cells, thereby inhibiting normal hematopoiesis , and cause extramedullary infiltration. The pathogenesis of AML is complicated and the clinical prognosis is poor. Although combined chemotherapy can achieve complete remission (CR) in most patients, only a few special types of AML patients can survive for a long time, and most patients develop disease within 3 years after CR. Relapse, and refractory or relapse patients have poor chemotherapy effect, so individualized treatment targeting key molecules in the occurrence a...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886G01N33/574A61K48/00A61K38/17A61P35/02
CPCC12Q1/6886G01N33/57426A61K48/005A61K38/1709A61P35/02C12Q2600/158
Inventor 陈春燕付悦崔泽龙
Owner SHANDONG UNIV QILU HOSPITAL
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