2 results about "Cytogenetics" patented technology

Genome whole chromosome analysis is a critical gold standard method for clinicians to study molecular lesions at single cell level in diseases and cancers. However, they suffer from low-sample-yielding, labor-intensive procedures that require subjective manual involvement of highly trained professionals. Here we disclose new devices, systems, and methods to automate, standardize, and accelerate the digital cytopathological sample and data generation with improved data quality to enable precision medicine and improve clinical practice. This disclosure describes a family of micro-fluidic devices, and accompanying methods for using said devices, to perform cytogenomic analysis on cells, nucleus, vesicles exosomes and their respective chromosomes, chromatins, nucleic acid polymers, subcellular genomic elements and any other dynamic transitional states between these forms. Collectively, these microfluidic devices allow for the consistent physical manipulation and preparation of macromolecules to substantially improve the quality of the of the cytogenetic information being interrogated.

The embodiment of the present application discloses a kind of intelligent chromosome harvesting systems, belong to the technical field of cytogenetics detection.It includes: oscillation module, for executing oscillation operation to test tube;Centrifugal module, for executing centrifugation operation;Liquid extraction module, for extracting supernatant;Image acquisition module, for collecting sample image after oscillation and / or after centrifugation;Intelligent analysis module, for identifying test tube boundary frame, and analyzing image in frame to identify the mixing state and / or centrifugation state of sample;Control module, for: when sample is not mixed, drive oscillation module to repeat oscillation until mixing;When it has been mixed, drive centrifugal module to centrifuge;When sample is not layered, drive centrifugal module to repeat centrifugation or alarm;When it has been layered, drive liquid extraction module to extract supernatant.The present application can realize closed loop oscillation mixing, automatically judge layering and full-process automatic control.