8 results about "Transcription factor activity" patented technology

Provided are a transcription factor activity inferring method, an apparatus, a storage medium, and a computer device, relating to the field of transcription factor activity inference. Provided is a method for performing transcription factor activity inference for spatial transcriptome sequencing data. The method specifically comprises: combining spatial position information of genes in the spatial transcriptome sequencing data with a single-cell transcription factor activity analysis method to perform transcription factor activity inference on the spatial transcriptome sequencing data. The method can improve the accuracy of performing transcription factor activity inference on the basis of spatial transcriptome sequencing technology.

The present disclosure relates to compounds that modulate the activity of transcription factor SOX18. More particularly, due to the modulation of transcription factor SOX18, the compounds present as useful therapies in the treatment of angiogenesis- and lymphangiogenesis- related diseases, disorders, or conditions.

This invention discloses the application of an inhibitor of transcription factor C / EBPβ in the preparation of a drug for treating postmenopausal osteoporosis. This invention also discloses the application of transcription factor C / EBPβ in screening drugs that reduce postmenopausal FSH levels, wherein the drugs inhibit the expression of transcription factor C / EBPβ. Furthermore, this invention discloses the application of compounds #11a and CF3CN in the preparation of a drug for treating postmenopausal osteoporosis. This invention reveals for the first time that the C / EBPβ-AEP pathway participates in promoting FSHβ synthesis in a menopausal model. By reducing the transcription factor activity of C / EBPβ, it can reduce FSH expression at the pituitary gland, promote osteogenic differentiation, inhibit osteoclast resorption, and effectively alleviate PMOP symptoms. Compounds #11a and CF3CN can effectively achieve both anti-bone resorption and bone formation-promoting functions, achieving coupled treatment of PMOP.

The invention covers an isolated nucleic acid composition that encodes a synthetic reporter capable of binding to a transcription factor, said composition comprising a) between four and eight copies of a consensus transcription factor binding site (TFBSs), b) between three and seven TFBSs-devoid spacer sequences between the TFBSs mentioned under a), c) one TFBS-devoid spacer sequence upstream of a core promoter, d) a core promoter and e) an unique barcode sequence and / or an open reading frame encoding a reporter protein. The invention also covers a library of isolated nucleic acid molecules that encode one or more synthetic reporters containing the designed spacer sequences and binding to one or more transcription factors, as well a kit containing all these elements and barcodes. The invention also covers a computer-implemented method for determining transcription factor (TF) reporter activities, as well as comparing the activities across different conditions. The invention also covers a computing apparatus and non-transitory computer-readable storage medium for performing the method.

The application discloses a Helitron transposon fragment related to citrus Huanglongbing resistance and application thereof. The nucleotide sequence of the Helitron transposon fragment is shown in sequence 2, which contains multiple characteristic motifs combined with transcription factor MYC2, the transcription factor MYC2 can be combined with and play the transcription factor activity to transcribe and activate the expression of PUB21 gene. The application confirms that PUB21 and the ubiquitination substrate MYC2 transcription factor constitute a close feedback loop, explains the molecular mechanism of different species sensitivity to Huanglongbing, and provides a breeding strategy for enhancing the disease resistance of citrus by knocking out or modifying the Helitron transposon fragment in the promoter region of the susceptible gene PUB21 to reduce the expression level of the susceptible gene PUB21, the resistance breeding strategy can effectively resist the replication and spread of Huanglongbing pathogen, and has important significance for preventing and controlling citrus Huanglongbing.

The present disclosure relates to compounds, compositions and methods for treating diseases or conditions mediated by aberrant bromodomain PHD finger transcription factor (BPTF) activity.

The present disclosure relates to an isolated compound including a phosphorothioated oligodeoxynucleotide (ODN) sequence conjugated to a short-activating RNA (saRNA) or an antisense oligonucleotide sequence (ASO), compositions of such a compound, and method of treatment of cancer and autoimmune diseases (with or without stimulating an immune response), method of immune stimulation, method of activating CEBPA, and method of reducing activity of STAT transcription factor, by one of the disclosed compounds or compositions.

Provided is use of an inhibitor of transcription factor C / EBPβ in preparing a medicament for treating postmenopausal osteoporosis (PMOP). Specifically, provided is use of compound # 11a and CF3CN in preparing a medicament for treating PMOP. The C / EBPβ-AEP pathway is involved in promoting the synthesis of FSHβ in menopausal models. By reducing the transcription factor activity of C / EBPβ, the expression of FSH in the pituitary can be reduced, thereby promoting osteogenic differentiation, inhibiting osteoclastic resorption, and effectively alleviating the symptoms of PMOP. Compounds # 11a and CF3CN can effectively achieve the dual functions of anti-bone resorption and osteogenesis promotion, thereby achieving a coupled therapeutic effect for PMOP.